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Identification
NameAC162352
Accession NumberDB05004
TypeSmall Molecule
GroupsInvestigational
DescriptionAC162352, a synthetic human PYY 3-36, is a compound being evaluated for the treatment of obesity. It reduces appetite and increases satiety in obese patients.
Structure
Thumb
Synonyms
PYY 3-36
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
CategoriesNot Available
UNIINot Available
CAS numberNot Available
WeightNot Available
Chemical FormulaNot Available
InChI KeyNot Available
InChINot Available
IUPAC NameNot Available
SMILESNot Available
Pharmacology
IndicationInvestigated for use/treatment in metabolic disease and obesity.
Structured Indications Not Available
PharmacodynamicsNot Available
Mechanism of actionPYY 3-36 acts via the presynaptic Y2 receptor in the ARC. It decreases neuropeptide Y (NPY) release from static hypothalamic explants and thus acts to decrease food intake.
TargetKindPharmacological actionActionsOrganismUniProt ID
Neuropeptide Y receptor type 2ProteinunknownNot AvailableHumanP49146 details
Neuropeptide Y receptor type 1ProteinunknownNot AvailableHumanP25929 details
Neuropeptide Y receptor type 5ProteinunknownNot AvailableHumanQ15761 details
Neuropeptide Y receptor type 4ProteinunknownNot AvailableHumanP50391 details
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug InteractionsNot Available
Food InteractionsNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External LinksNot Available
ATC CodesNot Available
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
ADMET
Predicted ADMET featuresNot Available
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental PropertiesNot Available
Predicted PropertiesNot Available
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Taxonomy
ClassificationNot classified

Targets

Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Receptor activity
Specific Function:
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.
Gene Name:
NPY2R
Uniprot ID:
P49146
Molecular Weight:
42730.69 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Peptide yy receptor activity
Specific Function:
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.
Gene Name:
NPY1R
Uniprot ID:
P25929
Molecular Weight:
44391.535 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Peptide yy receptor activity
Specific Function:
Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.
Gene Name:
NPY5R
Uniprot ID:
Q15761
Molecular Weight:
50725.99 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Peptide yy receptor activity
Specific Function:
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid.
Gene Name:
NPY4R
Uniprot ID:
P50391
Molecular Weight:
42194.55 Da
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Drug created on October 21, 2007 16:23 / Updated on August 17, 2016 12:24