AC162352

Identification

Name
AC162352
Accession Number
DB05004
Type
Small Molecule
Groups
Investigational
Description

AC162352, a synthetic human PYY 3-36, is a compound being evaluated for the treatment of obesity. It reduces appetite and increases satiety in obese patients.

Synonyms
  • PYY 3-36
Categories
Not Available
UNII
Not Available
CAS number
Not Available
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication

Investigated for use/treatment in metabolic disease and obesity.

Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action

PYY 3-36 acts via the presynaptic Y2 receptor in the ARC. It decreases neuropeptide Y (NPY) release from static hypothalamic explants and thus acts to decrease food intake.

TargetActionsOrganism
UNeuropeptide Y receptor type 2Not AvailableHuman
UNeuropeptide Y receptor type 1Not AvailableHuman
UNeuropeptide Y receptor type 5Not AvailableHuman
UNeuropeptide Y receptor type 4Not AvailableHuman
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Substance
347909887

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
Not AvailableCompletedTreatmentBMI >30 kg/m21

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Targets

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Receptor activity
Specific Function
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] N...
Gene Name
NPY2R
Uniprot ID
P49146
Uniprot Name
Neuropeptide Y receptor type 2
Molecular Weight
42730.69 Da
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Peptide yy receptor activity
Specific Function
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-3...
Gene Name
NPY1R
Uniprot ID
P25929
Uniprot Name
Neuropeptide Y receptor type 1
Molecular Weight
44391.535 Da
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Peptide yy receptor activity
Specific Function
Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involv...
Gene Name
NPY5R
Uniprot ID
Q15761
Uniprot Name
Neuropeptide Y receptor type 5
Molecular Weight
50725.99 Da
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Peptide yy receptor activity
Specific Function
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34...
Gene Name
NPY4R
Uniprot ID
P50391
Uniprot Name
Neuropeptide Y receptor type 4
Molecular Weight
42194.55 Da

Drug created on October 21, 2007 16:23 / Updated on November 06, 2017 06:45