Hormones
Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects.
| Drug | Drug Name | Drug Indication |
|---|---|---|
| DB00007 | Leuprolide | For treatment of prostate cancer, endometriosis, uterine fibroids and premature puberty |
| DB00010 | Sermorelin | For the treatment of dwarfism, prevention of HIV-induced weight loss |
| DB00014 | Goserelin | Used to treat hormone-sensitive cancers of the breast (in pre- and peri- menopausal women) and prostate, and some benign gynaecological disorders (endometriosis, uterine fibroids and endometrial thinning). In addition, goserelin is used in assisted reproduction and in the treatment of precocious puberty. |
| DB00017 | Salmon Calcitonin | Used in the treatment of symptomatic Paget's disease for patients unresponsive to alternate treatments or intolerant to such treatments. In addition, it is used in emergency situations when serum calcium levels must be decreased quickly until the underlying condition is identified. It can also be added to existing therapeutic regimens for hypercalcemia such as intravenous fluids and furosemide, oral phosphate or corticosteroids, or other agents. Calcitonin can be used in patients with azotemia and cases where intravenous fluids would be contraindicated due to limited cardiac reserves. Also for the treatment of post-menopausal osteoporosis in women more than 5 years post-menopause. |
| DB00021 | Secretin | For diagnosis of pancreatic exocrine dysfunction and gastrinoma |
| DB00024 | Thyrotropin Alfa | For detection of residueal or recurrent thyroid cancer |
| DB00030 | Insulin Human | Indicated as an adjunct to diet and exercise to improve glycemic control in adults and children with type 1 and type 2 diabetes mellitus. |
| DB00032 | Menotropins | For the treatment of female infertility |
| DB00035 | Desmopressin | - Indicated for the treatment of nocturia due to nocturnal polyuria in adults who awaken at least 2 times per night to void (intranasal). - Indicated as antidiuretic replacement therapy in the management of central cranial diabetes insipidus and for management of the temporary polyuria and polydipsia following head trauma or surgery in the pituitary region (intranasal/parenteral). - Indicated for patients with hemophilia A with factor VIII coagulant activity levels greater than 5% or mild to moderate classic von Willebrand's Disease (Type I) with factor VIII levels greater than 5% during surgical procedures and postoperatively to maintain hemostasis (parenteral). |
| DB00040 | Glucagon recombinant | For treatment of severe hypoglycemia, also used in gastrointestinal imaging |
| DB00044 | Lutropin alfa | For treatment of infertility in women with hypothalamic or pituitary insufficiency (hypogonadotropic hypogonadism) and profound LH deficiency (LH <1.2 international units [IU]/L) |
| DB00046 | Insulin Lispro | For the treatment of Type 1 or 2 diabetes mellitus. To be used in conjunction with an intermediate or long-acting insulin except when used in a continuous insulin infusion pump. |
| DB00047 | Insulin Glargine | For the treatment of Type 1 or 2 diabetes mellitus in patients over 17 years old who require a long-acting (basal) insulin for the control of hyperglycemia. May be used in pediatric patients with Type 1 diabetes mellitus who require a long-acting (basal) insulin for glycemic control. |
| DB00050 | Cetrorelix | For the inhibition of premature LH surges in women undergoing controlled ovarian stimulation |
| DB00052 | Somatotropin | For treatment of dwarfism, acromegaly and prevention of HIV-induced weight loss |
| DB00066 | Follitropin | In women having been diagnosed with primary ovarian failure, it is used in combination with human chorionic gonadotropin (hCG) to assist in ovulation and fertility. In men with hypogonadotrophic hypogonadism, it is used to induce spermatogenesis. Follitropin may also be used to cause the ovary to produce several follicles, which can then be harvested for use in gamete intrafallopian transfer (GIFT) or in vitro fertilization (IVF). |
| DB00067 | Vasopressin | For the treatment of enuresis, polyuria, diabetes insipidus, polydipsia and oesophageal varices with bleeding |
| DB00071 | Insulin Pork | For the treatment of type I and II diabetes mellitus. |
| DB00082 | Pegvisomant | Pegvisomant is a growth hormone receptor antagonist used for the treatment of acromegaly. |
| DB00093 | Felypressin | For use as an alternative to adrenaline as a localising agent, provided that local ischaemia is not essential. |
| DB00094 | Urofollitropin | For treatment of female infertility |
| DB00107 | Oxytocin | Used for labor induction, augmentation of labor, postpartum abbreviation of third stage of labor, postpartum control of uterine bleeding, termination of pregnancy and for the evaluation of fetal respiratory capability. Oxytocin cannot be used for elective induction of labor, there must be a clear medical requirement. |
| DB00183 | Pentagastrin | Used as a diagnostic aid for evaluation of gastric acid secretory function |
| DB00223 | Diflorasone | For relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatoses. |
| DB00240 | Alclometasone | For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. |
| DB00253 | Medrysone | For the treatment of allergic conjunctivitis, vernal conjunctivitis, episcleritis, and epinephrine sensitivity. |
| DB00255 | Diethylstilbestrol | Used in the treatment of prostate cancer. Previously used in the prevention of miscarriage or premature delivery in pregnant women prone to miscarriage or premature delivery. |
| DB00269 | Chlorotrianisene | Used to treat symptoms of menopause, deficiencies in ovary function (including underdevelopment of female sexual characteristics and some types of infertility), and in rare cases, prostate cancer. Chlorotrianisene may also be used to prevent breast engorgement following childbirth. |
| DB00279 | Liothyronine | Used as replacement or supplemental therapy in patients with hypothyroidism of any etiology, except transient hypothyrodism during the recovery phase of subacute thyroiditis. |
| DB00286 | Conjugated estrogens | Conjugated Equine Estrogens (CEEs) are indicated for the following conditions: treatment of moderate to severe vasomotor symptoms and vulvovaginal atrophy associated with menopause; hypoestrogenism due to hypogonadism, castration or primary ovarian failure; palliation of metastatic breast cancer; palliation of advanced androgen-dependent carcinoma of the prostate; and for prevention of postmenopausal osteoporosis. |
| DB00288 | Amcinonide | For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. |
| DB00304 | Desogestrel | For the prevention of pregnancy in women who elect to use this product as a method of contraception. |
| DB00324 | Fluorometholone | For the ophthalmic treatment of corticosteroid-responsive inflammation of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe. |
| DB00378 | Dydrogesterone | Used to treat irregular duration of cycles and irregular occurrence and duration of periods caused by progesterone deficiency. Also used to prevent natural abortion in patients who have a history of habitual abortions. |
| DB00394 | Beclomethasone dipropionate | Used in the maintenance treatment of asthma as prophylactic therapy in patients 5 years of age and older, and in treating symptoms for allergic rhinitis (seasonal or perennial) in patients 12 years of age and older. Also being investigated for oral treatment in mild-to-moderate Crohn's disease of ileal or ileal-right colonic localisation and for "topical" use mild-to-moderate graft versus host disease. |
| DB00396 | Progesterone | For progesterone supplementation or replacement as part of an Assisted Reproductive Technology (ART) treatment for infertile women with progesterone deficiency and for the treatment of secondary amenorrhea. Also used for the reduction of the incidence of endometrial hyperplasia and the attendant risk of endometrial carcinoma in postmenopausal women receiving estrogen replacement therapy, as well as treatment of abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology such as fibroids or uterine cancer. |
| DB00443 | Betamethasone | Topical use (cream, lotion and ointment): for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Topical use (foam): relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses of the scalp. Systemic use: for the treatment of edocrine disorders, rheumatic disorders, collagen diseases, dermatological diseases, allergic states, ophthalmic diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, gastrointestinal diseases, tuberculous meningitis and trichinosis. |
| DB00451 | Levothyroxine | For use alone or in combination with antithyroid agents to treat hypothyroidism, goiter, chronic lymphocytic thyroiditis, myxedema coma, and stupor. |
| DB00470 | Dronabinol | For the treatment of anorexia associated with weight loss in patients with AIDS, and nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments |
| DB00509 | Dextrothyroxine | Used to lower high cholesterol levels in the blood. |
| DB00547 | Desoximetasone | For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. |
| DB00591 | Fluocinolone Acetonide | For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also for the treatment of chronic non-infectious uveitis affecting the posterior segment of the eye (Retisert). |
| DB00603 | Medroxyprogesterone acetate | Used as a contraceptive and to treat secondary amenorrhea, abnormal uterine bleeding, pain associated with endometriosis, endometrial and renal cell carcinomas, paraphilia in males, GnRH-dependent forms of precocious puberty, as well as to prevent endometrial changes associated with estrogens. |
| DB00620 | Triamcinolone | For the treatment of perennial and seasonal allergic rhinitis. |
| DB00621 | Oxandrolone | Use to promote weight gain after weight loss following extensive surgery. |
| DB00624 | Testosterone | To be used as hormone replacement or substitution of diminished or absent endogenous testosterone. Use in males: For management of congenital or acquired hypogonadism, hypogonadism associated with HIV infection, and male climacteric (andopause). Use in females: For palliative treatment of androgen-responsive, advanced, inoperable, metastatis (skeletal) carcinoma of the breast in women who are 1-5 years postmenopausal; testosterone esters may be used in combination with estrogens in the management of moderate to severe vasomotor symptoms associated with menopause in women who do not respond to adequately to estrogen therapy alone. |
| DB00635 | Prednisone | For the treatment of drug-induced allergic reactions, perennial or seasonal allergic rhinitis, serum sickness, giant cell arteritis acute rheumatic or nonrheumatic carditis, systemic dermatomyositis, systemic lupus erythematosus, atopic dermatitis, contact dermatitis, exfoliative dermatitis, bullous dermatitis herpetiformis, severe seborrheic dermatitis, severe (Stevens-Johnson syndrome) erythema multiforme, mycosis fungoides, pemphigus, severe psoriasis, acute adrenocortical insufficiency, Addison's disease, secondary adrenocortical insufficiency, congenital adrenal hyperplasia, hypercalcemia associated with neoplasms, nonsuppurative thyroiditis, ulceratice colitis, Crohn's disease, acquired hemolytic anemia, congenital hypoplastic anemia, erythroblastopenia, adult secondary thrombocytopenia, adult idiopathic thrombocytopenia purpura, acute or subacute bursitis, epicondylitis, acute nonspecific tenosynovitis, acute or chronic lymphocytic leukemia, Hodgkin's or non-Hodgkin's lynphomas, Waldenstrom's macroglobulinemia, primary brain tumors (adjunct), nephrotic syndrome, tuberculous meningitis, multiple sclerosis, myasthenia gravis. cerebral edema, chorioretinitis, diffuse posterior choroiditis, aleergic conjunctivitis, Herpes zoster ophthalmicus, anterior segment inflammation, iridocyclitis, iritis, keratitis, optoc neuritis, sympathetic ophthalmia, corneal marginal allergic ulcers, symptomatic sarcoidosis, Loeffler's syndrome not manageable by other means, berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy and aspiration pneumonitis. |
| DB00644 | Gonadorelin | For evaluating the functional capacity and response of the gonadotropes of the anterior pituitary also for evaluating residual gonadotropic function of the pituitary following removal of a pituitary tumor by surgery and/or irradiation. |
| DB00655 | Estrone | For management of perimenopausal and postmenopausal symptoms. |
| DB00663 | Flumethasone | For the treatment of contact dermatitis, atopic dermatitis, exczema, psoriasis, diaper rash and other skin conditions |
| DB00666 | Nafarelin | For treatment of central precocious puberty (true precocious puberty, GnRH-dependent precocious precocity, complete isosexual precocity) in children of both sexes and for the treatment of endometriosis. |
| DB00687 | Fludrocortisone | For partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenogenital syndrome. |
| DB00717 | Norethisterone | For the treatment of secondary amenorrhea, endometriosis, and abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology, such as submucous fibroids or uterine cancer. |
| DB00741 | Hydrocortisone | For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease. |
| DB00783 | Estradiol | Estradiol is indicated for the treatment of moderate to severe vasomotor symptoms and vulvar and vaginal atrophy due to menopause, for the treatment of hypoestrogenism due to hypogonadism, castration, or primary ovarian failure, and for the prevention of post-menopausal osteoarthritis. It is also used for the treatment of breast cancer (for palliation only) in appropriately selected women and men with metastatic disease, and for the treatment of advanced androgen-dependent carcinoma of the prostate (for palliation only). |
| DB00838 | Clocortolone | For short-term topical treatment of the inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp. |
| DB00846 | Flurandrenolide | For relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses, particularly dry, scaling localized lesions |
| DB00860 | Prednisolone | For the treatment of primary or secondary adrenocortical insufficiency, such as congenital adrenal hyperplasia, thyroiditis. Also used to treat psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, bursitis, acute gouty arthritis and epicondylitis. Also indicated for treatment of systemic lupus erythematosus, pemphigus and acute rhematic carditis. Can be used in the treatment of leukemias, lymphomas, thrombocytopenia purpura and autoimmune hemolytic anemia. Can be used to treat celiac disease, insulin resistance, ulcerative colitis and liver disorders. |
| DB00890 | Dienestrol | For use in the treatment of atrophic vaginitis and kraurosis vulvae. |
| DB00896 | Rimexolone | For the treatment of postoperative inflammation following ocular surgery and in the treatment of anterior uveitis. |
| DB00947 | Fulvestrant | For the treatment of hormone receptor positive metastatic breast cancer in postmenopausal women with disease progression following anti-estrogen therapy. |
| DB00959 | Methylprednisolone | Adjunctive therapy for short-term administration in rheumatoid arthritis. |
| DB00977 | Ethinyl Estradiol | For treatment of moderate to severe vasomotor symptoms associated with the menopause, female hypogonadism, prostatic carcinoma-palliative therapy of advanced disease, breast cancer, as an oral contraceptive, and as emergency contraceptive. |
| DB00984 | Nandrolone phenpropionate | For the treatment of refractory deficient red cell production anemias, breast carcinoma, hereditary angioedema, antithrombin III deficiency, fibrinogen excess, growth failure and Turner's syndrome. It is also indicated in the prophylaxis of hereditary angioedema. |
| DB01013 | Clobetasol propionate | For short-term topical treatment of the inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp. |
| DB01047 | Fluocinonide | A topical anti-inflammatory product for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. |
| DB01065 | Melatonin | Used orally for jet lag, insomnia, shift-work disorder, circadian rhythm disorders in the blind (evidence for efficacy), and benzodiazepine and nicotine withdrawal. Evidence indicates that melatonin is likely effective for treating circadian rhythm sleep disorders in blind children and adults. It has received FDA orphan drug status as an oral medication for this use. A number of studies have shown that melatonin may be effective for treating sleep-wake cycle disturbances in children and adolescents with mental retardation, autism, and other central nervous system disorders. It appears to decrease the time to fall asleep in children with developmental disabilities, such as cerebral palsy, autism, and mental retardation. It may also improve secondary insomnia associated with various sleep-wake cycle disturbances. Other possible uses for which there is some evidence for include: benzodiazepine withdrawal, cluster headache, delayed sleep phase syndrome (DSPS), primary insomnia, jet lag, nicotine withdrawal, preoperative anxiety and sedation, prostate cancer, solid tumors (when combined with IL-2 therapy in certain cancers), sunburn prevention (topical use), tardive dyskinesia, thrombocytopenia associated with cancer, chemotherapy and other disorders. |
| DB01108 | Trilostane | Used in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible. |
| DB01130 | Prednicarbate | For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. |
| DB01134 | Desoxycorticosterone Pivalate | Examined for treatment of adrenocortical insufficiency especially in multiple sclerosis, congenital cerebral palsy, polyarteritis nodosa, and rheumatoid arthritis. Currently only approved in treating cats and dogs for the treatment of Addison's disease. |
| DB01185 | Fluoxymesterone | In males, used as replacement therapy in conditions associated with symptoms of deficiency or absence of endogenous testosterone. In females, for palliation of androgenresponsive recurrent mammary cancer in women who are more than one year but less than five years postmenopausal. |
| DB01196 | Estramustine | For the palliative treatment of patients with metastatic and/or progressive carcinoma of the prostate |
| DB01222 | Budesonide | The oral capsule is used for the treatment of mild to moderate active Crohn's disease. The oral tablet is used for induction of remission in patients with active, mild to moderate ulcerative colitis. The oral inhalation formulation is used for the treatment of asthma, non-infectious rhinitis (including hay fever and other allergies), and for treatment and prevention of nasal polyposis. |
| DB01234 | Dexamethasone | Injection: for the treatment of endocrine disorders, rheumatic D=disorders, collagen diseases, dermatologic diseases, allergic statesc, ophthalmic diseases, gastrointestinal diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, cerebral edema.
Ophthalmic ointment and solution: for the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe. Ophthalmic solution only: for the treatment of steroid responsive inflammatory conditions of the external auditory meatus Topic cream: for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses Oral aerosol: for the treatment of bronchial asthma and related corticosteroid responsive bronchospastic states intractable to adequate trial of conventional therapy Intranasal aerosol: for the treatment of allergic ot inflammatory nasal conditions, and nasal polyps |
| DB01261 | Sitagliptin | For use as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus. Also for use in patients with type 2 diabetes mellitus to improve glycemic control in combination with metformin or a PPARγ agonist (e.g., thiazolidinediones) when the single agent alone, with diet and exercise, does not provide adequate glycemic control. |
| DB01276 | Exenatide | Indicated as adjunctive therapy to improve glycemic control in patients with Type 2 diabetes mellitus who are taking metformin, a sulfonylurea, or a combination of both, but have not achieved adequate glycemic control. |
| DB01278 | Pramlintide | For the treatment of type 1 and type 2 diabetes mellitus as an adjunct to preprandial insulin therapy in patients without adequate glycemic control of insulin therapy. |
| DB01282 | Carbetocin | Used to control postpartum hemorrhage and bleeding after giving birth. |
| DB01284 | Tetracosactide | For use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency. |
| DB01285 | Corticotropin | For use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency. |
| DB01306 | Insulin Aspart | For the treatment of Type 1 or 2 diabetes mellitus. Should normally be used in conjunction with an intermediate or long-acting insulin. |
| DB01307 | Insulin Detemir | For the treatment of type 1 or 2 diabetes mellitus. May be used in combination with oral anti-diabetic agents in type 2 diabetic patients who are not in adequate metabolic control with oral anti-diabetic agents alone. |
| DB01309 | Insulin Glulisine | For the treatment of Type 1 and 2 diabetes mellitus. Should be used in regimens including a long-acting or basal insulin analogue unless it is used in a continuous infusion pump. May be used with oral antidiabetic agents. |
| DB01357 | Mestranol | Mestranol was used as one of the first oral contraceptives. |
| DB01380 | Cortisone acetate | For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders. |
| DB01384 | Paramethasone | For the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less suitable than hydrocortisone with supplementary fludrocortisone. |
| DB01410 | Ciclesonide | For the treatment of nasal symptoms associated with seasonal and perennial allergic rhinitis in adults and adolescents 12 years of age and older. |
| DB01420 | Testosterone propionate | Testosterone propionate is often used for muscle mass building. The original medical indication is for the treatment of androgen deficiency in male adults either in hypogonadism or andropause.[L1161] Nowadays testosterone propionate is indicated for its use in heifers in order to stimulate maximal growth.[L1160] |
| DB01431 | Allylestrenol | Allylestrenol was designed to be used for miscarriage prevention, prevention of premature labour and has been investigated for possible use in men for treatment for benign prostatic hyperplasia. |
| DB01434 | 19-norandrostenedione | The claim that supplemental 19-norandrostenedione has anabolic effects is unsubstantiated. |
| DB01456 | 5-androstenedione | Not Available |
| DB01471 | Bolasterone | Not Available |
| DB01481 | 1-Testosterone | Not Available |
| DB01485 | 4-Hydroxytestosterone | Not Available |
| DB01493 | Ethylestrenol | Not Available |
| DB01521 | Clostebol | Not Available |
| DB01524 | Androstenediol | Not Available |
| DB01536 | Androstenedione | Not Available |
| DB01541 | Boldenone | Not Available |
| DB01554 | Bolandiol | Not Available |
| DB01564 | Calusterone | An anabolic steroid which can theoretically aid in restauration and buildup of certain tissues, especially muscle. It is similar to synthetic testosterone and is still in early investigation. It was also investigated for use as a treatment for metastatic breast cancer. |
| DB01583 | Liotrix | May be used to treat primary, secondary or tertiary hypothyroidism. May also be used to suppress thyroid stimulating hormone (TSH) secretion in patients with simple (nontoxic) goiter, subacute or chronic lymphocytic thyroiditis multinodular goiter, and in the management of thyroid cancer. May be used in conjunction with other antithyroid agents to treat thyrotoxicosis to prevent goitrogenesis and hypothyroidism. May also be used for differential diagnosis of suspected mild hyperthyroidism or thyroid gland autonomy. |
| DB01645 | Genistein | Currently Genistein is being studied in clinical trials as a treatment for prostate cancer. |
| DB01708 | Prasterone | DHEA is taken as a supplement for a variety of unsubstantiated indications. The following indications have shown promise and are backed up by some scientific evidence: schizophrenia (DHEA may be more effective in women than men); improving the appearance of older people’s skin (taking DHEA by mouth seems to increase skin thickness and moisture, and decrease facial “age spots” in elderly men and women); improving ability to achieve an erection in men with sexual dysfunction. Additionally, DHEA has shown promise in improving symptoms of lupus (SLE). Taking DHEA by mouth along with conventional treatment may help reduce the number of times symptoms flare up and may allow a reduction in the dose of prescription drugs needed. DHEA may also help SLE symptoms such as muscle ache and mouth ulcers. DHEA also seems to strengthen bones in SLE patients being treated with high-dose steroids (corticosteroids). DHEA also shows promise in the treatment of osteoporosis. Taking DHEA by mouth daily seems to improve bone mineral density (BMD) in older women and men with osteoporosis or osteopenia (pre-osteoporosis). DHEA may also increase BMD in young women with the eating disorder called anorexia nervosa. DHEA is often prescribed in India for the induction of ovulation to improve chances of pregnancy. |
| DB02187 | Equilin | For the treatment of moderate to severe vasomotor symptoms associated with the menopause, atrophic vaginitis, osteoporosis, hypoestrogenism due to hypogonadism, castration, primary ovarian failure, breast cancer (for palliation only), and Advanced androgen-dependent carcinoma of the prostate (for palliation only) |
| DB02323 | EM-1745 | Not Available |
| DB02342 | 2-Methoxyestradiol | For the treatment of breast cancer and inflammatory diseases such as rheumatoid arthritis. |
| DB02638 | Terlipressin | Commonly used to stop bleeding of varices in the food pipe (oesophagus). |
| DB02789 | Pregnenolone | Not Available |
| DB02901 | Stanolone | Not Available |
| DB03515 | Equilenin | Not Available |
| DB04468 | Afimoxifene | For the potential treatment of menstrual-cycle related mastalgia, fibrocystic breast disease, breast disease, gynecomastia and Keloid scarring. |
| DB04573 | Estriol | Used as a test to determine the general health of an unborn fetus. |
| DB04574 | Estrone sulfate | Estropipate is used for the treatment of moderate to severe vasomotor symptoms associated with the monopause, and moderate to severe symptoms of vulval and vaginal atrophy associated with the menopause. It is also used to treat hypoestrogenism due to hypogonadism, castration or primary ovarian failure, and prevent postmenopausal osteoporosis. |
| DB04575 | Quinestrol | Used in hormone replacement therapy, treating symptoms of menopause such as hot flashes. Also used to treat breast and prostate cancer. |
| DB04630 | Aldosterone | Not Available |
| DB04652 | Corticosterone | Not Available |
| DB04870 | Oleoyl-estrone | For the treatment of obesity. |
| DB04894 | Vapreotide | For the treatment of esophageal variceal bleeding in patients with cirrhotic liver disease and has also shown efficacy in the treatment of patients with AIDS-related diarrhea. |
| DB04899 | Nesiritide | For the intravenous treatment of patients with acutely decompensated congestive heart failure who have dyspnea at rest or with minimal activity. |
| DB04900 | Thymalfasin | Indicated as an adjuvant for influenza vaccine in elderly patients and as an adjuvant for both influenza and hepatitis B vaccines in chronic hemodialysis patients who failed to achieve adequate antibody titers from previous immunization. |
| DB04914 | G17DT | Intended for the treatment of various forms of cancer. |
| DB04931 | Afamelanotide | Investigated for use/treatment in actinic keratosis, keratoses, skin cell studies, and skin infections/disorders. |
| DB05034 | Ularitide | Investigated for use/treatment in congestive heart failure. |
| DB05084 | Abaloparatide | Investigated for use/treatment in postmenopausal osteoporosis to reduce vertebral and/or non-vertebral fractures. |
| DB05098 | Leptin | Investigated for use/treatment in lipodystrophy and obesity. |
| DB05107 | 16-Bromoepiandrosterone | Investigated for use/treatment in cystic fibrosis, HIV infection, hepatitis (viral, B), and malaria. |
| DB05115 | NN344 | Investigated for use/treatment in diabetes mellitus type 1 and 2. |
| DB05212 | HE3286 | For the treatment of rheumatoid arthritis and type 2 diabetes. |
| DB05288 | anecortave acetate | Investigated for use/treatment in glaucoma and macular degeneration. |
| DB05394 | Corticorelin | Investigated for use/treatment in brain cancer and neurologic disorders. |
| DB05402 | ME-609 | Investigated for use/treatment in herpes labialis infections (cold sores). |
| DB05410 | NCX 1022 | Investigated for use/treatment in atopic dermatitis. |
| DB05442 | Etiprednol dicloacetate | Investigated for use/treatment in asthma and crohn's disease. |
| DB05804 | Prasterone sulfate | Investigated for use/treatment in asthma and burns and burn infections. |
| DB05819 | NBI-6024 | Investigated for use/treatment in diabetes mellitus type 1 and pediatric indications. |
| DB05829 | Parathyroid hormone | For use/treatment in osteoporosis. |
| DB05830 | Trestolone | Investigated for use/treatment in contraception and male hormonal deficiencies/abnormalities. |
| DB06155 | Rimonabant | For use in conjunction with diet and exercise for patients with a body mass index greater than 30 kg/m2, or patients wih a BMI greater than 27 kg/m2 with associated risk factors, such as type 2 diabetes or dyslipidaemia. |
| DB06157 | Istaroxime | Investigated for use/treatment in heart disease. |
| DB06203 | Alogliptin | Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. |
| DB06250 | Fluasterone | Investigated for use/treatment in psoriasis and psoriatic disorders, hyperlipidemia, metabolic disease, cancer/tumors (unspecified), and obesity. |
| DB06260 | Aviptadil | Not Available |
| DB06285 | Teriparatide | For the treatment of osteoporosis in men and postmenopausal women who are at high risk for having a fracture. Also used to increase bone mass in men with primary or hypogonadal osteoporosis who are at high risk for fracture. |
| DB06335 | Saxagliptin | Treatment of type 2 diabetes mellitus to improve glycemic control in combination with other agents or as monotherapy. |
| DB06412 | Oxymetholone | Indicated in the treatment of anemias caused by deficient red cell production. Acquired aplastic anemia, congenital aplastic anemia, myelofibrosis and the hypoplastic anemias due to the administration of myelotoxic drugs often respond. Oxymetholone should not replace other supportive measures such as transfusion, correction of iron, folic acid, vitamin B12 or pyridoxine deficiency, antibacterial therapy and the appropriate use of corticosteroids. |
| DB06645 | Anamorelin | Investigated for use/treatment in cachexia and anorexia. |
| DB06655 | Liraglutide | For use in/treatment of diabetes mellitus type 2. |
| DB06663 | Pasireotide | For the treatment of Cushing’s disease, specifically for those patients whom pituitary surgery has not been curative or is not an option. |
| DB06710 | Methyltestosterone | Methyltestosterone is an anabolic steroid hormone used to treat men with a testosterone deficiency. It is also used in women to treat breast cancer, breast pain, swelling due to pregnancy, and with the addition of estrogen it can treat symptoms of menopause. |
| DB06718 | Stanozolol | Stanozolol is a synthetic anabolic steroid with therapeutic uses in treating C1-inhibitor deficient hereditary angioedema. C1-inhibitor is a protease that inhibits the complement system (part of the innate immune system), a biochemical chain of reactions which assists the body in removing pathogens from the body. Stanozolol may help control attacks of hereditary angioedema. Stanozolol can be administered orally or intramuscularly. |
| DB06719 | Buserelin | Buserelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction. |
| DB06730 | Gestodene | Not Available |
| DB06763 | Saralasin | Not Available |
| DB06780 | Desoxycorticosterone acetate | Not Available |
| DB06781 | Difluprednate | For the treatment of inflammation and pain associated with ocular surgery. |
| DB06785 | Ganirelix | For the inhibition of premature LH surges in women undergoing controlled ovarian hyperstimulation. |
| DB06788 | Histrelin | As the product Supprelin LA (FDA), histrelin is indicated for the treatment of children with central precocious puberty (CPP). As the product Vantas (FDA), histrelin is indicated for the palliative treatment of advanced prostate cancer. |
| DB06789 | Hydroxyprogesterone caproate | Hydroxyprogesterone caproate is indicated for the prevention of spontaneous preterm births in singleton pregnancies in women who have previously had a spontaneous preterm birth. (1) |
| DB06791 | Lanreotide | Lanreotide is a somatostatin analog approved for treatment of neuroendocrine tumours and acromegaly. (2) |
| DB06825 | Triptorelin | Triptorelin is indicated for the palliative treatment of advanced prostate cancer. |
| DB07706 | 2-Hydroxyestradiol | Not Available |
| DB07931 | Hexestrol | Not Available |
| DB08619 | Testosterone succinate | Not Available |
| DB08804 | Nandrolone decanoate | For the treatment of refractory deficient red cell production anemias, breast carcinoma, hereditary angioedema, antithrombin III deficiency, fibrinogen excess, growth failure and Turner's syndrome. It is also indicated in the prophylaxis of hereditary angioedema. |
| DB08862 | Cholecystokinin | For use as a diagnostic aid for evaluation of gallbladder disorders. It is also used in conjunction with secretin in pancreatic insufficiency [L1634]. |
| DB08869 | Tesamorelin | Tesamorelin acetate is a synthetic analogue of human hypothalamic Growth Hormone Releasing Factor (hGRF) indicated to induce and maintain a reduction of excess abdominal fat in HIV-infected patients with lipodystrophy. |
| DB08882 | Linagliptin | Linagliptin is used for the management of type 2 diabetes mellitus. |
| DB08900 | Teduglutide | Treatment of short bowel syndrome (SBS), malabsorption associated with the removal of the intestine, in adults patients who are dependent on parenteral support. |
| DB08905 | Formestane | For the treatment of estrogen-receptor positive breast cancer in post-menopausal women. |
| DB08970 | Fluprednidene | Not Available |
| DB08971 | Fluocortolone | Not Available |
| DB09043 | Albiglutide | Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. |
| DB09045 | Dulaglutide | Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. |
| DB09046 | Metreleptin | Metreleptin is indicated as an adjunct to diet as replacement therapy to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy. |
| DB09059 | Atosiban | Atosiban is indicated for use in delaying imminent pre-term birth in pregnant adult women with: - regular uterine contractions of at least 30 s duration at a rate of at least 4 per 30 min - a cervical dilation of 1-3 cm (0-3 for nulliparas) and effacement of at least 50% - a gestational age from 24-33 completed weeks - a normal fetal heart rate |
| DB09066 | Corifollitropin alfa | Controlled ovarian stimulation [L2273] in cases of women who are undergoing fertility treatment to stimulate the development of more than one mature egg simultaneously in the ovaries in combination with a gonadotrophin-releasing hormone (GnRH) antagonist (a type of medicine also used in fertility treatments)[L2270]. |
| DB09067 | Corticorelin ovine triflutate | Corticorelin is indicated for use in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing's syndrome. |
| DB09070 | Tibolone | For the relief of post-menopausal symptoms and for the prevention of osteoporosis [L1724]. |
| DB09091 | Tixocortol | Tixocortol is indicated for the treatment of rhinitis as a nasal suspension or aerosol. It is also used in the form of lozenges for the treatment of pharyngitis and in the form of enemas or rectal solution for the treatment of ulcerative colitis. Tixocortol can be used orally in a suspension or powder for the treatment of inflammatory conditions.[L1077] It is also the substance used for the screening of contact allergies to class A steroids.[A31435] |
| DB09095 | Difluocortolone | Difluocortolone is used as a topical treatment of the symptoms of inflammatory skin disorders like eczema, seborrheic eczema, lichen planus and psoriasis. All these disorders present as a common characteristic the occurrence of symptoms as itching, swelling, redness and scaling.[L1083] |
| DB09098 | Somatrem | Somatrem is a recombinant human growth hormone indicated for: (a) treatment of paediatric patients with growth failure due to growth hormone deficiency (GHD), (b) treatment of paediatric patients with growth failure due to idiopathic short stature (ISS), (c) treatment of paediatric patients with growth failure due to Turner syndrome (TS), (d) treatment of paediatric patients with growth failure due to chronic kidney disease (CKD) up to the time of renal transplantation, (e) treatment of adults with childhood-onset GHD, or (f) treatment of adults with adult-onset GHD [FDA Label]. |
| DB09099 | Somatostatin | For the symptomatic treatment of acute bleeding from esophageal varices. Other treatment options for long-term management of the condition may be considered if necessary, once initial control has been established. |
| DB09123 | Dienogest | Indicated for use as the treatment of endometriosis alone and as a contraceptive in combination with ethinylestradiol. |
| DB09126 | Chorionic Gonadotropin (Human) | For the treatment of prepubertal cryptorchidism (not due to anatomical obstruction), for the treatment of selected cases of hypogonadotropic hypogonadism (hypogonadism secondary to a pituitary deficiency) in males and for the induction of ovulation and pregnancy in the anovulatory, infertile woman in whom the cause of anovulation is secondary and not due to primary ovarian failure, and who has been appropriately pretreated with human menotropins. |
| DB09142 | Sincalide | As the product Kinevac (FDA), sincalide is used for the following indications: 1) to stimulate gallbladder contraction, as may be assessed by various methods of diagnostic imaging, or to obtain by duodenal aspiration a sample of concentrated bile for analysis of cholesterol, bile salts, phospholipids, and crystals; (2) to stimulate pancreatic secretion (especially in conjunction with secretin) prior to obtaining a duodenal aspirate for analysis of enzyme activity, composition, and cytology; (3) to accelerate the transit of a barium meal through the small bowel, thereby decreasing the time and extent of radiation associated with fluoroscopy and x-ray examination of the intestinal tract. |
| DB09317 | Synthetic Conjugated Estrogens, A | For the treatment of moderate to severe vasomotor symptoms due to menopause and for treatment of moderate to severe symptoms of vulvar and vaginal atrophy due to menopause. |
| DB09318 | Synthetic Conjugated Estrogens, B | For the treatment of moderate to severe vasomotor symptoms due to menopause and for the treatment of moderate to severe vaginal dryness, pain with intercourse, and symptoms of vulvar and vaginal atrophy due to menopause. |
| DB09369 | Polyestradiol phosphate | Not Available |
| DB09378 | Fluprednisolone | Not Available |
| DB09421 | Protirelin | Not Available |
| DB09527 | Secretin porcine | Not Available |
| DB09564 | Insulin Degludec | Insulin degludec is indicated to improve glycemic control in adults with diabetes mellitus. |
| DB11510 | Deslorelin | Not Available |
| DB11567 | Insulin peglispro | Not Available |
| DB11619 | Gestrinone | Endometriosis with or without accompanying sterility. Treatment is limited to a single course of 6 months duration per lifetime [L1699, L1700]. |
| DB11653 | Bremelanotide | Not Available |
| DB11674 | Equol | Not Available |
| DB11700 | Setmelanotide | Not Available |
| DB11724 | Bombesin | Not Available |
| DB11750 | Clobetasol | Not Available |
| DB11777 | Cenderitide | Not Available |
| DB11842 | Angiotensin II | Angiotensin II is a vasoconstrictor indicated for increasing blood pressure in adults with septic or other distributive shock [FDA Label]. |
| DB11895 | Ghrelin | Not Available |
| DB11928 | Vosoritide | Not Available |
| DB11996 | Thymopentin | Not Available |
| DB12003 | Thymosin beta-4 | Not Available |
| DB12081 | Anecortave | Not Available |
| DB12088 | TT-232 | Not Available |
| DB12179 | Secoisolariciresinol | Not Available |
| DB12194 | Atamestane | Not Available |
| DB12235 | Estetrol | Not Available |
| DB12487 | Promestriene | Not Available |
| DB12495 | Selepressin | Not Available |
| DB12499 | Cortexolone 17α-propionate | Not Available |
| DB12602 | Pentetreotide | Not Available |
| DB12629 | 3,5-diiodothyropropionic acid | Not Available |
| DB12649 | Ibipinabant | Not Available |
| DB12755 | Zoptarelin doxorubicin | Not Available |
| DB12777 | Somatoprim | Not Available |
| DB12787 | Norethandrolone | Not Available |
| DB12822 | Pancreatic Polypeptide | Not Available |
| DB13033 | Urocortin-2 | Not Available |
| DB13070 | Surinabant | Not Available |
| DB13158 | Clobetasone | In dermatology, topical clobestasone butyrate helps to reduce the itchiness and erythema associated with eczema and dermatitis. In ophthalmology, clobetasone butyrate 0.1% eye drops have been shown to be safe and effective in the treatment of dry eyes in Sjögren's Syndrome. |
| DB13169 | Nandrolone | Not Available |
| DB13182 | Daidzein | Not Available |
| DB13185 | Oxabolone cipionate | Used as a performance enhancing drug illicitly in athletes. |
| DB13587 | Mesterolone | Not Available |
| DB13928 | Semaglutide | Semaglutide is indicated to improve glycemic control in adults with type 2 diabetes mellitus as an adjunct of diet and exercise. The approved therapeutic doses are 0.5 mg and 1 mg.[L1068] Diabetes mellitus type 2 is a long-term metabolic disorder characterized by high blood sugar, insulin resistance and lack of insulin. Its onset is determined by the loss ability of beta cells to respond to an increased plasma glucose. This disease is predominantly caused by lifestyle factors like overweight and obesity. The key feature on type 2 diabetes is the presence of insulin resistance which reduced the capacity of insulin to exert its functions at normal at any given concentration. The secretion of insulin is stimulated by the action of incretins in the gut like glucagon-like peptide 1, which also delays gastric emptying and induces satiety, and glucose-dependent insulinotropic polypeptide.[T59] |
| DB13943 | Testosterone cypionate | Testosterone cypionate is used in males that present conditions derived from a deficiency or absence of endogenous testosterone. These conditions are 1) primary hypogonadism, defined as the testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome or orchidectomy; and 2) hypogonadotropic hypogonadism characterized by idiopathic gonadotropin, LHRH deficiency or pituitary-hypothalamic injury from tumors, trauma or radiation.[L1153] |
| DB13944 | Testosterone enanthate | Testosterone enanthate in males is indicated as a replacement therapy in conditions associated with a deficiency or absence of endogenous testosterone. Some of the treated conditions are 1) primary hypogonadism, defined as testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome or orchidectomy; 2) hypogonadotropic hypogonadism due to an idiopathic gonadotropin or luteinizing hormone-releasing hormone deficiency or due to a pituitary-hypothalamic injury from tumors, trauma or radiation, in this case it is important to accompany the treatment with adrenal cortical and thyroid hormone replacement therapy; 3) to stimulate puberty in patients with delayed puberty not secondary to a pathological disorder. If the conditions 1 and 2 occur prior to puberty, the androgen replacement therapy will be needed during adolescent years for the development of secondary sexual characteristics and prolonged androgen treatment might be needed it to maintain sexual characteristics after puberty.[FDA label] In females, testosterone enanthate is indicated to be used secondarily in presence of advanced inoperable metastatic mammary cancer in women who are from one to five years postmenopausal. It has also been used in premenopausal women with breast cancer who have benefited from oophorectomy and are considered to have a hormone-responsive tumor.[FDA label] |
| DB13946 | Testosterone undecanoate | Testosterone undecanoate is indicated as a testosterone replacement therapy in adult males that present conditions of deficiency or absence of endogenous testosterone. The approved conditions for the use of testosterone undecanoate are 1) primary hypogonadism, defined as a testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome, orchiectomy, Klinefelter's syndrome, chemotherapy or toxic damage from alcohol or heavy metals: or 2) hypogonadotropic hypogonadism caused by idiopathic gonadotropin or luteinizing hormone-releasing hormone deficiency or pituitary-hypothalamic injuries from tumors, trauma or radiation.[FDA label] |
| DB13947 | Testosterone enantate benzilic acid hydrazone | Not Available |
| DB13953 | Estradiol benzoate | Estradiol benzoate is not currently available in any FDA or Health Canada approved products. |
| DB13954 | Estradiol cypionate | Depo-Estradiol intramuscular depot injection is indicated for the treatment of moderate to severe vasomotor symptoms and hypoestrogenism due to hypogonadism. |
| DB13955 | Estradiol dienanthate | Estradiol dienanthate is not currently available in any FDA or Health Canada approved products. |
| DB13956 | Estradiol valerate | Estradiol valerate is commercially available as an intramuscular injection as the product Delestrogen and is indicated for the treatment of moderate to severe vasomotor symptoms and vulvovaginal atrophy due to menopause, for the treatment of hypoestrogenism due to hypogonadism, castration or primary ovarian failure, and for the treatment of advanced androgen-dependent carcinoma of the prostate (for palliation only). Estradiol valerate is also available in combination with [DB09123] as the commercially available product Natazia used for the prevention of pregnancy and for the treatment of heavy menstrual bleeding. |
| DB13958 | Trestolone acetate | Not Available |
| DB14027 | Taspoglutide | Not Available |
| DB14043 | Palmidrol | Not Available |