Carbon dioxide

Identification

Name
Carbon dioxide
Accession Number
DB09157
Type
Small Molecule
Groups
Approved, Investigational, Vet approved
Description

Carbon dioxide is a colorless, odorless gas vital to life on Earth. This naturally occurring chemical compound is composed of a carbon atom covalently double bonded to two oxygen atoms. Medical Carbon Dioxide is a liquefied medicinal gas, supplied in cylinders filled to a high pressure. Medical Carbon Dioxide may be used in different situations, e.g. during bodily investigations, to inflate body cavities during surgery (such as key-hole surgery), iand in solid form (dry ice) for freezing of tissue and removal of warts.

Structure
Thumb
Synonyms
Not Available
External IDs
E-290 / INS NO.290 / INS-290
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Air 90% Carbon Dioxide 10%Gas100 mL/1LRespiratory (inhalation)A-OX WELDING SUPPLY CO., INC.2015-03-11Not applicableUs
Carbon DioxideGas990 mL/1LRespiratory (inhalation)Linde Merchant Production Llc1965-01-01Not applicableUs
Carbon DioxideGas990 mL/1LRespiratory (inhalation)Praxair Distribution, Inc.2008-09-01Not applicableUs
Carbon DioxideGas995 mL/1LRespiratory (inhalation)Westair Gases & Equipment, Inc.2000-01-01Not applicableUs
Carbon DioxideGas990 mL/1LRespiratory (inhalation)Roberts Oxygen Company, Inc.2011-11-01Not applicableUs
Carbon DioxideGas990 mL/1LRespiratory (inhalation)AGL Inhalation Therapy Co.1966-01-01Not applicableUs
Carbon DioxideGas99 L/100LRespiratory (inhalation)Air Liquide Canada Inc.1960-01-012016-10-01Us
Carbon DioxideGas99 L/100LRespiratory (inhalation)Nlr Welding Supply, Inc.1986-01-01Not applicableUs
Carbon DioxideGas990 mL/1LRespiratory (inhalation)Oxarc, Inc.2015-07-09Not applicableUs
Carbon DioxideGas1000 mL/1LRespiratory (inhalation)Airgas Carbonic, Inc.2009-12-29Not applicableUs
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Carbon DioxideGas990 mL/1LRespiratory (inhalation)AGL Inhalation Therapy Co.1966-01-01Not applicableUs
Carbon Dioxide 99%Gas99.0 %Respiratory (inhalation)Air Products Canada Ltd/LtÉe.1988-12-312003-06-13Canada
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
CarbogenCarbon dioxide (50 %) + Oxygen (50 %)GasRespiratory (inhalation)Linde Llc1995-12-31Not applicableCanada
Carbon Dioxide 1% W AirCarbon dioxide (15 %) + Medical air (85 %)GasRespiratory (inhalation)Liquid Carbonic Inc.1990-12-311998-06-09Canada
Carbon Dioxide 1% W OxygenCarbon dioxide (7 %) + Oxygen (93 %)GasRespiratory (inhalation)Liquid Carbonic Inc.1990-12-311998-06-09Canada
Carbon Dioxide 12.1% W OxygenCarbon dioxide (23 %) + Oxygen (77 %)GasRespiratory (inhalation)Praxair, Inc.1990-12-31Not applicableCanada
Carbon Dioxide 15.1% W AirCarbon dioxide (30 %) + Medical air (70 %)GasRespiratory (inhalation)Liquid Carbonic Inc.1990-12-311998-06-09Canada
Carbon Dioxide 23.1% W OxygenCarbon dioxide (50 %) + Oxygen (50 %)GasRespiratory (inhalation)Praxair, Inc.1990-12-31Not applicableCanada
Carbon Dioxide 30.1% W AirCarbon dioxide (50 %) + Medical air (50 %)GasRespiratory (inhalation)Liquid Carbonic Inc.1990-12-311998-06-09Canada
Carbon Dioxide 7.1% W OxygenCarbon dioxide (12 %) + Oxygen (88 %)GasRespiratory (inhalation)Praxair, Inc.1990-12-31Not applicableCanada
Carbon Dioxide In Oxygen MixtureCarbon dioxide (10 %) + Oxygen (90 %)GasRespiratory (inhalation)Matheson Gas Products Canada Inc.1983-12-311997-12-24Canada
Carbon Dioxide MixtureCarbon dioxide (12 %) + Nitrogen (65 %) + Oxygen (23 %)GasRespiratory (inhalation)Liquid Carbonic Inc.1990-12-311998-06-09Canada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
CarbogenCarbon dioxide (5 mL/1L) + Oxygen (95 mL/1L)GasRespiratory (inhalation)WestAir Gases and Equipment, Inc.2000-01-01Not applicableUs
Carbon DioxideCarbon dioxide (990 mL/1L)GasRespiratory (inhalation)Praxair, Puerto Rico Inc.2005-10-01Not applicableUs
Carbon DioxideCarbon dioxide (992 mL/1L)GasRespiratory (inhalation)Airgas Northern California And Nevada, Inc.1965-01-01Not applicableUs
Carbon DioxideCarbon dioxide (990 mL/1L)GasRespiratory (inhalation)Airgas Usa Llc2000-07-202016-06-06Us
Carbon DioxideCarbon dioxide (990 mL/1L)GasRespiratory (inhalation)Airgas East, Inc.1991-01-22Not applicableUs
Carbon DioxideCarbon dioxide (992 mL/1L)GasRespiratory (inhalation)Airgas Norpac Inc.1983-01-01Not applicableUs
Carbon DioxideCarbon dioxide (990 mL/1L)GasRespiratory (inhalation)Abco Welding And Industrial Supply Inc2010-05-01Not applicableUs
Carbon DioxideCarbon dioxide (990 mL/1L)GasRespiratory (inhalation)Nordan Smith Welding Supply1994-01-12Not applicableUs
Carbon DioxideCarbon dioxide (995 mL/1L)GasRespiratory (inhalation)Medical-Technical Gases, Inc.1963-01-01Not applicableUs
Carbon DioxideCarbon dioxide (99 L/100L)GasRespiratory (inhalation)Linde Gas North America LLC1990-11-28Not applicableUs
Categories
UNII
142M471B3J
CAS number
124-38-9
Weight
Average: 44.0095
Monoisotopic: 43.989829244
Chemical Formula
CO2
InChI Key
CURLTUGMZLYLDI-UHFFFAOYSA-N
InChI
InChI=1S/CO2/c2-1-3
IUPAC Name
methanedione
SMILES
O=C=O

Pharmacology

Indication

Carbon dioxide is commonly used as an insufflation gas for minimal invasive surgery (laparoscopy, endoscopy, and arthroscopy) to enlarge and stabilize body cavities to provide better visibility of the surgical area. It has been used also in cryotherapy and as respiratory stimulant before and after anesthesia. It could be used also in expansion of blood vessels if required, to increase carbon dioxide level after rapid breathing, and to stimulate breathing after a period of nonbreathing.

Pharmacodynamics

Data not found.

Mechanism of action

Data not found.

Absorption

Data not found.

Volume of distribution

Data not found.

Protein binding

No protein binding data.

Metabolism

Not metabolized.

Route of elimination

Data not found.

Half life

Data not found.

Clearance

Data not found.

Toxicity

Signs of intoxication have been produced by a 30-minute exposure at 50,000 ppm , and a few minutes exposure at 70,000 to 100,000 ppm produces unconsciousness.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. product leaflet [Link]
  2. product info [Link]
External Links
Human Metabolome Database
HMDB0001967
KEGG Drug
D00004
KEGG Compound
C00011
PubChem Compound
280
PubChem Substance
310265070
ChemSpider
274
ChEBI
16526
ChEMBL
CHEMBL1231871
PharmGKB
PA448801
HET
CO2
Wikipedia
Carbon_dioxide
ATC Codes
V03AN02 — Carbon dioxide
AHFS Codes
  • 92:00.00 — Miscellaneous Therapeutic Agents
  • 36:89.00* — Other Diagnostics
  • 92:92.00 — Other Miscellaneous Therapeutic Agents
PDB Entries
1e5h / 1kek / 1krc / 1r3q / 2bgi / 2c3y / 2fvy / 2h31 / 2i61 / 2olq
show 44 more

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1RecruitingHealth Services ResearchRespiratory Depression1
1TerminatedDiagnosticNeoplasms1
2CompletedTreatmentHeadaches / Pain NOS / Temporomandibular Disorders1
2CompletedTreatmentNasal Stuffiness1
2CompletedTreatmentPerennial Allergic Rhinitis (PAR)1
2CompletedTreatmentTrigeminal Neuralgia (TN)1
2TerminatedTreatmentCluster Headache1
2TerminatedTreatmentMigraines1
2, 3TerminatedTreatmentFebrile Convulsions1
3CompletedTreatmentBladder Cancers1
Not AvailableCompletedDiagnosticHysteroscopy, Distension Medium, Pain1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
GasRespiratory (inhalation)100 mL/1L
GasIntragastric99 L/100L
GasIntraperitoneal; Respiratory (inhalation); Soft tissue992 mL/1L
GasRespiratory (inhalation)1 g/1g
GasRespiratory (inhalation)1000 mL/1L
GasRespiratory (inhalation)900 mL/1L
GasRespiratory (inhalation)99 kg/100kg
GasRespiratory (inhalation)99 L/100L
GasRespiratory (inhalation)990 mL/1L
GasRespiratory (inhalation)990 g/1kg
GasRespiratory (inhalation)991 mL/1L
GasRespiratory (inhalation)992 mL/1L
GasRespiratory (inhalation)995 mL/1L
GasRespiratory (inhalation)100 %
GasRespiratory (inhalation)
GasRespiratory (inhalation)99.0 %
GasRespiratory (inhalation)200 mL/1L
GasRespiratory (inhalation)50 mL/1L
GasRespiratory (inhalation)99 %
LiquidCutaneous992 mL/1L
GasRespiratory (inhalation)
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility186.0 mg/mLALOGPS
logP-0.63ALOGPS
logP-0.28ChemAxon
logS0.63ALOGPS
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area34.14 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity6.38 m3·mol-1ChemAxon
Polarizability2.57 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
GC-MS Spectrum - EI-BGC-MSsplash10-0006-9000000000-ffb540455919d1e43969
Mass Spectrum (Electron Ionization)MSsplash10-0006-9000000000-e1cf88df1066f206d01f
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0006-9000000000-eb2207f7400e9144fff7
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0006-9000000000-eb2207f7400e9144fff7
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0006-9000000000-eb2207f7400e9144fff7
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0006-9000000000-b7e6c1e22f1f90c5a8e0
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0006-9000000000-b7e6c1e22f1f90c5a8e0
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0006-9000000000-b7e6c1e22f1f90c5a8e0

Taxonomy

Description
This compound belongs to the class of inorganic compounds known as other non-metal oxides. These are inorganic compounds containing an oxygen atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen belongs to the class of 'other non-metals'.
Kingdom
Inorganic compounds
Super Class
Homogeneous non-metal compounds
Class
Other non-metal organides
Sub Class
Other non-metal oxides
Direct Parent
Other non-metal oxides
Alternative Parents
Inorganic oxides
Substituents
Other non-metal oxide / Inorganic oxide
Molecular Framework
Not Available
External Descriptors
one-carbon compound, carbon oxide (CHEBI:16526) / a small molecule (CARBON-DIOXIDE)

Drug created on October 02, 2015 11:00 / Updated on October 21, 2018 20:36