Identification

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Name
Oxygen
Accession Number
DB09140
Type
Small Molecule
Groups
Approved, Vet approved
Description

Oxygen is an element displayed by the symbol O, and atomic number 8. It is an essential element for human survival. Decreased oxygen levels may be treated with medical oxygen therapy. Treatment with oxygen serves to increase blood oxygen levels and also exerts a secondary effect of decreasing blood flow resistance in the diseased lung, leading to decreased cardiovascular workload in an attempt to oxygenate the lungs. Oxygen therapy is used to treat emphysema, pneumonia, some heart disorders (congestive heart failure), some disorders that cause increased pulmonary artery pressure, and any disease that impairs the body's ability to take up and use gaseous oxygen. Higher level of oxygen than ambient air (hyperoxia) can be introduced under normobaric or hyperbaric conditions.

Structure
Thumb
Synonyms
  • Dioxygen
  • Molecular oxygen
  • Oxigeno gaseoso
  • Oxygen USP
  • Pure oxygen
External IDs
E-948 / INS NO.948 / INS-948
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
AirGas210 mL/1LRespiratory (inhalation)Central Welding Supply Company2015-11-15Not applicableUs
AirGas210 mL/1LRespiratory (inhalation)General Air Service & Supply Co1974-08-01Not applicableUs
AirGas210 mL/1LRespiratory (inhalation)Agl Welding Supply Co., Inc.1966-01-01Not applicableUs
AirGas210 mL/1LRespiratory (inhalation)Djb Gas Services, Inc2017-11-07Not applicableUs
AirGas995 mL/1LRespiratory (inhalation)Westair Gases & Equipment, Inc.2000-01-01Not applicableUs
AirGas210 mL/1LRespiratory (inhalation)Haun Specialty Gases, Inc.2005-01-04Not applicableUs
AirGas21 L/1LRespiratory (inhalation)Lampton Welding Supply Company, Inc2018-04-18Not applicableUs
AirGas210 mL/1LRespiratory (inhalation)Airgas Usa, Llc1997-11-06Not applicableUs
AirGas210 mL/1LRespiratory (inhalation)Hartman Brothers, Inc.1977-07-01Not applicableUs
AirGas210 mL/1LRespiratory (inhalation)ILMO Products Company2009-01-01Not applicableUs
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
OxygenGas992 mL/1LRespiratory (inhalation)Arkansas Welding & Industrial Supply2001-10-20Not applicableUs
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

    Learn more
  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

    Learn more
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Air USPOxygen (19.5 %) + Nitrogen (80.5 %)GasRespiratory (inhalation)Praxair, Inc.1993-12-31Not applicableCanada
Alnox GasOxygen (50 %) + Nitrous oxide (50 %)GasRespiratory (inhalation)Air Liquide Canada Inc.1995-12-31Not applicableCanada
CarbogenOxygen (50 %) + Carbon dioxide (50 %)GasRespiratory (inhalation)Linde Llc1995-12-31Not applicableCanada
Carbon Dioxide 1% W OxygenOxygen (93 %) + Carbon dioxide (7 %)GasRespiratory (inhalation)Liquid Carbonic Inc.1990-12-311998-06-09Canada
Carbon Dioxide 12.1% W OxygenOxygen (77 %) + Carbon dioxide (23 %)GasRespiratory (inhalation)Praxair, Inc.1990-12-31Not applicableCanada
Carbon Dioxide 23.1% W OxygenOxygen (50 %) + Carbon dioxide (50 %)GasRespiratory (inhalation)Praxair, Inc.1990-12-31Not applicableCanada
Carbon Dioxide 7.1% W OxygenOxygen (88 %) + Carbon dioxide (12 %)GasRespiratory (inhalation)Praxair, Inc.1990-12-31Not applicableCanada
Carbon Dioxide In Oxygen MixtureOxygen (90 %) + Carbon dioxide (10 %)GasRespiratory (inhalation)Matheson Gas Products Canada Inc.1983-12-311997-12-24Canada
Carbon Dioxide MixtureOxygen (23 %) + Carbon dioxide (12 %) + Nitrogen (65 %)GasRespiratory (inhalation)Liquid Carbonic Inc.1990-12-311998-06-09Canada
Carbon Dioxide USP, Oxygen USP Medical G.M.Oxygen (93 %) + Carbon dioxide (7 %)GasRespiratory (inhalation)Praxair, Inc.1993-12-31Not applicableCanada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
AirOxygen (210 mL/1L)GasRespiratory (inhalation)Praxair, Puerto Rico Inc.2005-10-01Not applicableUs
AirOxygen (195 mL/1000mL)GasRespiratory (inhalation)Industrial Gas Distributors Inc1987-04-012015-12-29Us
AirOxygen (99 L/100L) + Nitrogen (99 L/100L)GasRespiratory (inhalation)Air Liquide Canada Inc.1960-01-012010-06-15Us
AirOxygen (23 L/100L) + Nitrogen (77 L/100L)GasRespiratory (inhalation)Air Liquide Canada Inc.1960-01-01Not applicableUs
AirOxygen (210 mL/1L)GasRespiratory (inhalation)Airgas Mid South, Inc.1997-11-062010-03-02Us
AirOxygen (20.9 L/100L)GasRespiratory (inhalation)Indianapolis Welding Supply, Inc1972-01-012013-04-12Us
AirOxygen (210 mL/1L)GasRespiratory (inhalation)Airgas Usa, Llc1997-11-062014-03-31Us
Air CompressedOxygen (20 L/100L)GasRespiratory (inhalation)Specialty Gases Of America1995-01-012015-06-10Us
Air Compressed Medical AirOxygen (21 L/100L)GasRespiratory (inhalation)Vagabond Welding Supply2013-04-01Not applicableUs
CarbogenOxygen (95 mL/1L) + Carbon dioxide (5 mL/1L)GasRespiratory (inhalation)WestAir Gases and Equipment, Inc.2000-01-01Not applicableUs
Categories
UNII
S88TT14065
CAS number
7782-44-7
Weight
Average: 31.9988
Monoisotopic: 31.989829244
Chemical Formula
O2
InChI Key
MYMOFIZGZYHOMD-UHFFFAOYSA-N
InChI
InChI=1S/O2/c1-2
IUPAC Name
oxidanone
SMILES
O=O

Pharmacology

Indication

Oxygen therapy in clinical settings is used across diverse specialties, including various types of anoxia, hypoxia or dyspnea and any other disease states and conditions that reduce the efficiency of gas exchange and oxygen consumption such as respiratory illnesses, trauma, poisonings and drug overdoses. Oxygen therapy tries to achieve hyperoxia 6 to reduce the extent of hypoxia-induced tissue damage and malfunction.

Pharmacodynamics

Oxygen therapy improves effective cellular oxygenation, even at a low rate of tissue perfusion. Oxygen molecules adjust hypoxic ventilatory drive by acting on chemoreceptors on carotid bodies that sequentially relay sensory information to the higher processing centers in brainstem. It also attenuates hypoxia-induced mitochondrial depolarization that generates reactive oxygen species and/or apoptosis. Studies investigating on hyperbaric oxygen therapy has shown that oxygen supplementation can induce neural stem cell proliferation in neonatal rats thus promoting neurological regeneration after injuries 3. CD34+, CD45-dim leukocytes are also potential targets for hyperbaric oxygen therapy benefit as their mobilization was increased in vitro which could facilitate the acceleration of recovery at peripheral sites 1.

Mechanism of action

Oxygen therapy increases the arterial pressure of oxygen and is effective in improving gas exchange and oxygen delivery to tissues, provided that there are functional alveolar units. Oxygen plays a critical role as an electron acceptor during oxidative phosphorylation in the electron transport chain through activation of cytochrome c oxidase (terminal enzyme of the electron transport chain). This process achieves successful aerobic respiration in organisms to generate ATP molecules as an energy source in many tissues. Oxygen supplementation acts to restore normal cellular activity at the mitochondrial level and reduce metabolic acidosis. There is also evidence that oxygen may interact with O2-sensitive voltage-gated potassium channels in glomus cells and cause hyperpolarization of mitochondrial membrane 4.

TargetActionsOrganism
UCytochrome c oxidase subunit 1
agonist
activator
Humans
UNADPH oxidase 1
agonist
activator
Humans
UHemoglobin subunit alphaNot AvailableHumans
UHemoglobin subunit betaNot AvailableHumans
Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption
Not Available
Volume of distribution
Not Available
Protein binding

Oxygen binds to oxygen-carrying protein in red blood cells called hemoglobin with high affinity. The amount of oxygen molecules bound to the fixed amount of circulating hemoglobin in the blood determines the overall oxygen saturation level and this oxygen-delivering capacity is regulated by Bohr effect.

Metabolism
Not Available
Route of elimination

Exhalation

Half life

Approximately 122.24 seconds

Clearance
Not Available
Toxicity

May cause burns or frostbites in case of eye or skin contact with rapidly expanding gas. Oxygen therapy can induce hypercapnic respiratory failure in patients with respiratory diseases and musculoskeletal diseases in upper airways. Sudden cessation of oxygen supplementation in these patients can further lead to rebound hypoxaemia. In patients with mild or moderate strokes, hyperoxaemia may cause absorption atelectasis or myocardial infarction. Oxygen content should be monitored following the administration to verify therapeutic benefit.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. Heyboer M 3rd, Milovanova TN, Wojcik S, Grant W, Chin M, Hardy KR, Lambert DS, Logue C, Thom SR: CD34+/CD45-dim stem cell mobilization by hyperbaric oxygen - changes with oxygen dosage. Stem Cell Res. 2014 May;12(3):638-45. doi: 10.1016/j.scr.2014.02.005. Epub 2014 Feb 28. [PubMed:24642336]
  2. Prabhakar NR: Oxygen sensing by the carotid body chemoreceptors. J Appl Physiol (1985). 2000 Jun;88(6):2287-95. [PubMed:10846047]
  3. Feng Z, Liu J, Ju R: Hyperbaric oxygen treatment promotes neural stem cell proliferation in the subventricular zone of neonatal rats with hypoxic-ischemic brain damage. Neural Regen Res. 2013 May 5;8(13):1220-7. doi: 10.3969/j.issn.1673-5374.2013.13.007. [PubMed:25206416]
  4. Lopez-Barneo J, Gonzalez-Rodriguez P, Gao L, Fernandez-Aguera MC, Pardal R, Ortega-Saenz P: Oxygen sensing by the carotid body: mechanisms and role in adaptation to hypoxia. Am J Physiol Cell Physiol. 2016 Apr 15;310(8):C629-42. doi: 10.1152/ajpcell.00265.2015. Epub 2016 Jan 13. [PubMed:26764048]
  5. Liu W, Khatibi N, Sridharan A, Zhang JH: Application of medical gases in the field of neurobiology. Med Gas Res. 2011 Jun 27;1(1):13. doi: 10.1186/2045-9912-1-13. [PubMed:22146102]
  6. British Thoracic Society: Guideline for emergency oxygen use in adult patients [Link]
  7. Airgas SDS [Link]
  8. Linde SDS [Link]
External Links
Human Metabolome Database
HMDB0001377
KEGG Drug
D00003
KEGG Compound
C00007
PubChem Compound
977
PubChem Substance
310265054
ChemSpider
952
ChEBI
27140
ChEMBL
CHEMBL1234886
PharmGKB
PA450744
HET
OXY
Wikipedia
Oxygen
ATC Codes
V03AN01 — Oxygen
AHFS Codes
  • 92:00.00 — Miscellaneous Therapeutic Agents
  • 92:92.00 — Other Miscellaneous Therapeutic Agents
PDB Entries
1a4f / 1a6m / 1ash / 1b86 / 1dcc / 1dp6 / 1dz8 / 1e5d / 1f65 / 1faw
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MSDS
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Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedTreatmentLumbar Spinal Instability / Lumbar Spine Degeneration / Spinal Stenosis of Lumbar Region1
0Unknown StatusTreatmentPain, Neuropathic1
0WithdrawnTreatmentSymptomatic Osteoarthritis of the Knee1
1CompletedNot AvailableAsthma Bronchial1
1CompletedNot AvailableFlu caused by Influenza / Healthy Volunteers1
1CompletedNot AvailableMalignancies1
1CompletedBasic ScienceHealthy Volunteers1
1CompletedBasic ScienceInfluenza, Human1
1CompletedDiagnosticAsthma Bronchial / Chronic Obstructive Pulmonary Disease (COPD) / Cystic Fibrosis (CF) / Emphysema / Small Airways Disease1
1CompletedHealth Services ResearchArterial hypoxia / Hypercapnia1
1CompletedPreventionFlu caused by Influenza1
1CompletedPreventionHealthy Volunteers1
1CompletedPreventionMalignancies1
1CompletedTreatmentAcute Coronary Syndromes (ACS) / Inflammatory Reaction / Myocardial Infarction / Reperfusion Injury1
1CompletedTreatmentCluster Headache1
1RecruitingHealth Services ResearchRespiratory Depression1
1RecruitingTreatmentBladder Small Cell Neuroendocrine Carcinoma / Castration-Resistant Prostate Carcinoma / Metastatic Bladder Urothelial Carcinoma / Metastatic Urethral Urothelial Carcinoma / Prostate Carcinoma Metastatic in the Bone / Prostate Neuroendocrine Neoplasm / Prostate Small Cell Carcinoma / Stage III Bladder Cancer AJCC v8 / Stage III Prostate Cancer AJCC v8 / Stage III Urethral Cancer AJCC v8 / Stage IV Bladder Cancer AJCC v8 / Stage IV Prostate Cancer AJCC v8 / Stage IV Urethral Cancer AJCC v8 / Stage IVA Bladder Cancer AJCC v8 / Stage IVB Bladder Cancer AJCC v8 / Transitional Cell Carcinoma / Ureter Small Cell Carcinoma1
1RecruitingTreatmentIleus / Ogilvie Syndrome / Small intestinal obstruction1
1TerminatedDiagnosticNeoplasms1
1, 2CompletedPreventionFlu caused by Influenza / Human Immunodeficiency Virus (HIV) Infections1
1, 2CompletedTreatmentAirway Obstruction / Dyspnea1
1, 2RecruitingTreatmentHypoplastic Left Heart Syndrome (HLHS)1
1, 2TerminatedPreventionInfluenza, Human1
1, 2TerminatedTreatmentAcidosis, Respiratory / Chronic Lung Diseases / Hypoxemia1
1, 2WithdrawnTreatmentChronic Obstructive Airway Disease (COPD) With Co-existent Obstructive Sleep Apnea (Overlap Syndrome) / Chronic Obstructive Pulmonary Disease (COPD)1
2Active Not RecruitingTreatmentLymphedema, Secondary1
2CompletedPreventionFlu caused by Influenza1
2CompletedPreventionHealthy Volunteers1
2CompletedSupportive CarePulmonary Fibrosis1
2CompletedTreatmentAcne Rosacea / Acne Vulgaris / Atopic Dermatitis (AD) / Seborrheic Dermatitis1
2CompletedTreatmentAcute Myocardial Infarction (AMI)1
2CompletedTreatmentAnginal Pain1
2CompletedTreatmentCystic Fibrosis (CF)1
2CompletedTreatmentHealthy Volunteers1
2CompletedTreatmentHeart Arrest1
2CompletedTreatmentHeart Failure1
2CompletedTreatmentMigraine1
2CompletedTreatmentObstructive Sleep Apnea Syndrome (OSAS)1
2CompletedTreatmentPost-Concussive Symptoms / Traumatic Brain Injury (TBI)1
2CompletedTreatmentPulmonary Embolism (PE)1
2CompletedTreatmentNeurocostal neuralgia1
2Not Yet RecruitingTreatmentAcute Ischemic Stroke (AIS)1
2Not Yet RecruitingTreatmentCardiac Failure / Critical Illness1
2RecruitingTreatmentAcute Coronary Syndromes (ACS) / Acute Kidney Injury (AKI) / Prophylaxis of Contrast-induced nephropathy1
2RecruitingTreatmentObstructive Sleep Apnea (OSA)1
2SuspendedTreatmentLumbar Herniated Disc1
2TerminatedNot AvailableExercise Training1
2TerminatedTreatmentLabour Pain1
2TerminatedTreatmentSickle Cell Disorders1
2TerminatedTreatmentStatus Asthmaticus1
2, 3Active Not RecruitingPreventionChronic Lung Disease of Prematurity / Infants, Premature / Intraventricular Hemorrhage / Periventricular Leukomalacia1
2, 3CompletedPreventionHealthy or Stable Underlying Chronic Medical Condition1
2, 3Not Yet RecruitingTreatmentIschaemic Heart Diseases1
2, 3RecruitingPreventionCentral Nervous Injury / Decompression Sickness / Diving Medicine / Hyperbaric / Inflammatory Activity1
2, 3RecruitingTreatmentObstetrical analgesia therapy / Obstetrical Anesthesia / Postpartum Depression1
2, 3TerminatedTreatmentFebrile Convulsions1
2, 3TerminatedTreatmentPain, Acute1
3CompletedNot AvailableFlu caused by Influenza / Healthy Volunteers1
3CompletedDiagnosticCongenital Heart Disease With Pulmonary Hypertension / Idiopathic Pulmonary Arterial Hypertension / Prophylaxis of cardiomyopathy1
3CompletedPreventionFlu caused by Influenza3
3CompletedPreventionHealthy or Stable Chronic Illness1
3CompletedPreventionHealthy or Stable Underlying Chronic Medical Condition1
3CompletedTreatmentAcute Coronary Syndromes (ACS) / Acute Myocardial Infarction (AMI) / Ischemic Reperfusion Injury / Non-ST Elevation (NSTEMI) Myocardial Infarction / ST Elevation Myocardial Infarction (STEMI) / Unstable Angina Pectoris1
3CompletedTreatmentAcute Coronary Syndromes (ACS) / Non-ST Elevation (NSTEMI) Myocardial Infarction / ST Segment Elevation Acute Myocardial Infarction / Unstable Angina Pectoris1
3CompletedTreatmentAcute Respiratory Failure / High Flow Oxygen Cannula / Immunocompromised Host1
3CompletedTreatmentBladder Cancers1
3CompletedTreatmentBronchiolitis1
3CompletedTreatmentCardiac Complications1
3CompletedTreatmentChronic Lung Disease of Prematurity / Respiratory Distress Syndrome of Prematurity (Surfactant Dysfunction) / Surfactant Dysfunction1
3CompletedTreatmentHealthy Volunteers2
3CompletedTreatmentInjection Site Vesicles1
3CompletedTreatmentPregnancy termination therapy1
3Not Yet RecruitingTreatmentCentral Sleep Apnea / Heart Failure1
3RecruitingOtherVascular Diseases1
3RecruitingTreatmentCervical Cancers1
3TerminatedPreventionPain NOS1
3TerminatedTreatmentChronic Obstructive Pulmonary Disease (COPD)1
3TerminatedTreatmentDental Cares Under Kalinox's Inhalation1
3TerminatedTreatmentHeart Failure,Congestive1
3TerminatedTreatmentNewborn Infants / Persistent Fetal Circulation Syndrome / Pneumonia, Aspiration / Pulmonary Hypertension (PH) / Respiratory Distress Syndrome, Newborn / Respiratory Insufficiency1
3Unknown StatusTreatmentChronic Schizophrenia1
3Unknown StatusTreatmentFiberoptic Bronchoscopy1
4Active Not RecruitingTreatmentInterstitial Lung Disease (ILD) / Precapillary Pulmonary Hypertension1
4CompletedNot AvailableFlu caused by Influenza1
4CompletedNot AvailableHealthy Volunteers1
4CompletedBasic ScienceEmphysema1
4CompletedBasic ScienceFlu caused by Influenza6
4CompletedBasic ScienceFlu caused by Influenza / Healthy Volunteers1
4CompletedBasic ScienceHyperoxia / Hypoxia, Brain / Neurobehavioral Manifestations1
4CompletedBasic ScienceImmune Response to Influenza Vaccine / Influenza A Virus Infection / Influenza B Virus Infection1
4CompletedOtherEndoscopy / Insufflation1
4CompletedPreventionAsthma Bronchial1
4CompletedPreventionFlu caused by Influenza5
4CompletedPreventionInfluenza Vaccines Efficacy and Safety1
4CompletedPreventionLaparotomy2
4CompletedPreventionPain NOS1
4CompletedTreatmentAnaesthesia therapy2
4CompletedTreatmentAnalgesia / Bowel Cancer Screening / Colonoscopy / Entonox1
4CompletedTreatmentChronic Obstructive Pulmonary Disease (COPD)4
4CompletedTreatmentFlu caused by Influenza2
4CompletedTreatmentInfants / Persistent foetal circulation disorders / Respiratory Failure1
4CompletedTreatmentPain, Acute1
4CompletedTreatmentST Elevation Myocardial Infarction1
4Not Yet RecruitingOtherPre-oxygenation1
4Not Yet RecruitingTreatmentFeeling Anxious / Pain NOS1
4RecruitingBasic ScienceAnaesthesia therapy1
4RecruitingBasic ScienceEmphysema1
4RecruitingPreventionHypoxemic Respiratory Failure / Oxygen Toxicity1
4RecruitingPreventionPostoperative Cardiac Complication1
4RecruitingSupportive CarePrader-Willi Syndrome / Sleep Apnea, Central1
4RecruitingSupportive CareSystemic Inflammatory Response Syndrome (SIRS)1
4RecruitingTreatmentBrain Natriuretic Peptide / Cardiac Risk Patients / Perioperative / Supplemental Oxygen1
4RecruitingTreatmentBronchiolitis1
4RecruitingTreatmentInterstitial Lung Disease (ILD) / Precapillary Pulmonary Hypertension1
4RecruitingTreatmentOxidative Stress1
4RecruitingTreatmentPatients Requiring Diagnostic Gastroscopy Suitable for Sedation / Patients Requiring Diagnostic Gastroscopy With Sedation1
4RecruitingTreatmentSepsis1
4RecruitingTreatmentWounds, Nonpenetrating1
4TerminatedBasic ScienceFlu caused by Influenza1
4TerminatedPreventionFlu caused by Influenza1
4Unknown StatusBasic ScienceFlu caused by Influenza1
4Unknown StatusPreventionChronic Lung Disease of Prematurity / Respiratory Distress Syndrome (RDS)1
4Unknown StatusSupportive CareHealthy Volunteers1
4Unknown StatusTreatmentCardiovascular Disease (CVD) / Immune System Diseases / Nervous System Diseases / Respiratory Tract Diseases1
4Unknown StatusTreatmentPostpartum Haemorrhage (PPH)1
4WithdrawnPreventionHyperoxia1
Not AvailableActive Not RecruitingTreatmentElectronic Fetal Monitoring / Fetal Hypoxia / Fetal-Placental Circulation1
Not AvailableCompletedNot AvailableCerebral Oxygen Saturation1
Not AvailableCompletedNot AvailableEgg Hypersensitivity1
Not AvailableCompletedNot AvailableFlu caused by Influenza / H1N1 / Infection, Human Immunodeficiency Virus I1
Not AvailableCompletedNot AvailableHealthy Volunteers1
Not AvailableCompletedNot AvailableLaparotomy1
Not AvailableCompletedBasic ScienceFlicker-induced Vasodilatation1
Not AvailableCompletedBasic ScienceHealthy Volunteers1
Not AvailableCompletedBasic ScienceHealthy Volunteers / Normoxia / Systemic Hypoxia1
Not AvailableCompletedBasic ScienceResponse to Hyperoxia1
Not AvailableCompletedDiagnosticChronic Obstructive Pulmonary Disease (COPD)1
Not AvailableCompletedHealth Services ResearchImmune Response to Influenza Vaccination1
Not AvailableCompletedPreventionPerioperative Hyperoxygenation / Wound Infections1
Not AvailableCompletedPreventionPharyngitis1
Not AvailableCompletedSupportive Care30% Oxygen Concentration During Colorectal Surgery / 80% Oxygen Concentration During Colorectal Surgery / Oxygen Concentration During Colorectal Surgery1
Not AvailableCompletedSupportive CareCoronary Artery Disease1
Not AvailableCompletedTreatmentChronic Obstructive Pulmonary Disease (COPD)2
Not AvailableCompletedTreatmentChronic Obstructive Pulmonary Disease (COPD) / Endurance Shuttle Walking Test (Exercise at 85% of Maximal Shuttle Walking Test) / Exercise1
Not AvailableCompletedTreatmentArterial hypoxia / Chronic Obstructive Pulmonary Disease (COPD)1
Not AvailableCompletedTreatmentFlu caused by Influenza1
Not AvailableCompletedTreatmentHand Injuries/Disease Requiring Surgery to the Hand1
Not AvailableCompletedTreatmentHeadaches1
Not AvailableCompletedTreatmentUpper Airway Obstruction1
Not AvailableEnrolling by InvitationPreventionTonsillitis, Hypertrophy1
Not AvailableEnrolling by InvitationPreventionAdjunct to general anesthesia therapy1
Not AvailableNot Yet RecruitingBasic ScienceHyperoxia1
Not AvailableNot Yet RecruitingPreventionSpinal Stenosis of Lumbar Region1
Not AvailableNot Yet RecruitingTreatmentIntersticial Lung Disease1
Not AvailableRecruitingNot AvailableHabits / Influenza, Human / Respiratory Tract Infections (RTI) / Smoking1
Not AvailableRecruitingDiagnosticHigh Altitude Hypoxia / Neuromuscular Diseases1
Not AvailableRecruitingOtherChronic Obstructive Pulmonary Disease (COPD)1
Not AvailableRecruitingOtherCritical Illness / Respiratory Failure1
Not AvailableRecruitingPreventionSurgery, Cardiac1
Not AvailableRecruitingTreatmentAbscesses1
Not AvailableRecruitingTreatmentAbscesses / Joint dislocations / Perianal Abscess1
Not AvailableRecruitingTreatmentAortic Valve Disorder / Brain Injury / Coronary Heart Disease (CHD) / Renal Failure / Shock, Cardiogenic / Strokes1
Not AvailableRecruitingTreatmentApnoeic Oxygenation1
Not AvailableRecruitingTreatmentComplex Regional Pain Syndrome (CRPS)1
Not AvailableRecruitingTreatmentIdiopathic Pulmonary Fibrosis (IPF)1
Not AvailableRecruitingTreatmentIntermittent Hypoxemia / Primary apnea of premature newborns1
Not AvailableRecruitingTreatmentPulmonary Arterial Hypertension (PAH)1
Not AvailableRecruitingTreatmentSepsis1
Not AvailableTerminatedBasic ScienceFlu caused by Influenza1
Not AvailableTerminatedSupportive CareChronic Obstructive Pulmonary Disease (COPD)1
Not AvailableTerminatedTreatmentAcute Respiratory Distress Syndrome (ARDS) / Shock, Septic1
Not AvailableUnknown StatusNot AvailableCystic Fibrosis (CF)1
Not AvailableUnknown StatusBasic SciencePain NOS1
Not AvailableUnknown StatusTreatmentAnaesthesia therapy1
Not AvailableWithdrawnPreventionRespiratory Complications / Swallowing Disorders1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
GasRespiratory (inhalation)195 mL/1000mL
GasRespiratory (inhalation)20.9 L/100L
GasRespiratory (inhalation)21 L/1L
GasRespiratory (inhalation)235 mL/1L
GasRespiratory (inhalation)20 %
GasRespiratory (inhalation)
GasRespiratory (inhalation)800 mL/1L
GasRespiratory (inhalation)950 mL/1L
GasRespiratory (inhalation)50 mL/1L
GasRespiratory (inhalation)80 L/100L
GasRespiratory (inhalation)90 L/100L
GasRespiratory (inhalation)96 L/100L
GasRespiratory (inhalation)40 L/100L
GasRespiratory (inhalation)95 L/100L
GasRespiratory (inhalation)20 L/100L
GasRespiratory (inhalation)25 L/100L
GasRespiratory (inhalation)30 L/100L
GasRespiratory (inhalation)500 mL/1L
GasRespiratory (inhalation)21 L/100L
GasRespiratory (inhalation)23 L/100L
GasCutaneous; Respiratory (inhalation)992 mL/1L
GasNasal1 L/1L
GasNasal210 mL/1L
GasNasal99 L/100L
GasNasal; Respiratory (inhalation)1 L/1L
GasNasal; Respiratory (inhalation)995 mL/1L
GasRectal990 mL/1L
GasRespiratory (inhalation).99 L/1L
GasRespiratory (inhalation).995 L/1L
GasRespiratory (inhalation)100 L/99L
GasRespiratory (inhalation)1000 mL/1L
GasRespiratory (inhalation)210 mL/1L
GasRespiratory (inhalation)900 mL/1L
GasRespiratory (inhalation)93 mL/1L
GasRespiratory (inhalation)930 mL/1L
GasRespiratory (inhalation)99 L/100L
GasRespiratory (inhalation)99 L/1L
GasRespiratory (inhalation)99 mL/1L
GasRespiratory (inhalation)99 L/99L
GasRespiratory (inhalation)99 mL/100mL
GasRespiratory (inhalation)99.1 L/1L
GasRespiratory (inhalation)99.4 L/100L
GasRespiratory (inhalation)99.5 L/100L
GasRespiratory (inhalation)99.5 L/1L
GasRespiratory (inhalation)99.6 %
GasRespiratory (inhalation)99.6 L/100L
GasRespiratory (inhalation)99.6 L/1L
GasRespiratory (inhalation)99.8 L/1L
GasRespiratory (inhalation)99.8 L/100L
GasRespiratory (inhalation)99.9 L/1L
GasRespiratory (inhalation)99.9 L/100L
GasRespiratory (inhalation)990 mL/1L
GasRespiratory (inhalation)990 1/1L
GasRespiratory (inhalation)990 L/1L
GasRespiratory (inhalation)991 mL/1L
GasRespiratory (inhalation)992 1/1L
GasRespiratory (inhalation)992 mL/1L
GasRespiratory (inhalation)992 L/1000L
GasRespiratory (inhalation)992 mL/1000mL
GasRespiratory (inhalation)995 mL/1L
GasRespiratory (inhalation)995 L/1L
GasRespiratory (inhalation)995 mL/100L
GasRespiratory (inhalation)996 mL/1L
GasRespiratory (inhalation)997 mL/1L
GasRespiratory (inhalation)998 mL/1L
GasRespiratory (inhalation)999 mL/1L
GasRespiratory (inhalation)999 L/1000L
LiquidRespiratory (inhalation)1.13835106 kg/1L
LiquidRespiratory (inhalation)1000 g/1L
LiquidRespiratory (inhalation)210 mg/1kg
LiquidRespiratory (inhalation)99 1/100L
LiquidRespiratory (inhalation)99 L/100L
LiquidRespiratory (inhalation)992 L/1000L
LiquidRespiratory (inhalation)995 mL/1L
LiquidRespiratory (inhalation)999 L/1000L
GasRespiratory (inhalation)99.0 %
GasRespiratory (inhalation)99.95 %
GasRespiratory (inhalation)992 mL/100mL
GasRespiratory (inhalation)200 mL/1L
GasRespiratory (inhalation)0.99 kg/1kg
GasRespiratory (inhalation)11321 L/11321L
GasRespiratory (inhalation)196 L/196L
GasRespiratory (inhalation)240 L/240L
GasRespiratory (inhalation)396 L/396L
GasRespiratory (inhalation)659 L/659L
GasRespiratory (inhalation)1567 L/1567L
GasRespiratory (inhalation)6931 L/6931L
GasRespiratory (inhalation)3453 L/3453L
GasRespiratory (inhalation)8688 L/8688L
GasRespiratory (inhalation)99.9 %
GasRespiratory (inhalation)99.99 %
GasNasal; Oral100 %
GasRespiratory (inhalation)99.5 %
GasRespiratory (inhalation)250 mL/1L
GasRespiratory (inhalation)300 mL/1L
GasRespiratory (inhalation)330 mL/1L
GasRespiratory (inhalation)400 mL/1L
GasRespiratory (inhalation)600 mL/1L
Gas; liquidRespiratory (inhalation)99.5 %
GasRespiratory (inhalation)99.2 %
LiquidRespiratory (inhalation)1 L/1L
GasRespiratory (inhalation)1 L/1L
GasRespiratory (inhalation)99 %
GasRespiratory (inhalation)100 %
Prices
Not Available
Patents
Not Available

Properties

State
Gas
Experimental Properties
PropertyValueSource
melting point (°C)-218.4Airgas SDS
boiling point (°C)-183Airgas SDS
water solubility39mg/LLinde SDS
logP0.65SDS
Predicted Properties
PropertyValueSource
logP-0.28ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area34.14 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity2.89 m3·mol-1ChemAxon
Polarizability1.53 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-001i-9000000000-a9a93dd42f2cfa0b34c4
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-001i-9000000000-a9a93dd42f2cfa0b34c4
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-001i-9000000000-a9a93dd42f2cfa0b34c4
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-001i-9000000000-5e864878b295db174473
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-001i-9000000000-5e864878b295db174473
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-001i-9000000000-5e864878b295db174473

Taxonomy

Description
This compound belongs to the class of inorganic compounds known as other non-metal oxides. These are inorganic compounds containing an oxygen atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen belongs to the class of 'other non-metals'.
Kingdom
Inorganic compounds
Super Class
Homogeneous non-metal compounds
Class
Other non-metal organides
Sub Class
Other non-metal oxides
Direct Parent
Other non-metal oxides
Alternative Parents
Inorganic oxides
Substituents
Other non-metal oxide / Inorganic oxide
Molecular Framework
Not Available
External Descriptors
diatomic oxygen, elemental molecule (CHEBI:15379) / a non-metabolic compound (OXYGEN-MOLECULE)

Targets

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Agonist
Activator
General Function
Iron ion binding
Specific Function
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic su...
Gene Name
MT-CO1
Uniprot ID
P00395
Uniprot Name
Cytochrome c oxidase subunit 1
Molecular Weight
57040.91 Da
References
  1. Wilson MT, Antonini G, Malatesta F, Sarti P, Brunori M: Probing the oxygen binding site of cytochrome c oxidase by cyanide. J Biol Chem. 1994 Sep 30;269(39):24114-9. [PubMed:7929065]
  2. Thomson AJ, Greenwood C, Gadsby PM, Peterson J, Eglinton DG, Hill BC, Nicholls P: The structure of the cytochrome a3-CuB site of mammalian cytochrome c oxidase as probed by MCD and EPR spectroscopy. J Inorg Biochem. 1985 Mar-Apr;23(3-4):187-97. [PubMed:2991457]
  3. CuB-heme a3 (or heme o) binuclear centre associated with Cytochrome c oxidase subunit I as oxygen binding site [Link]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Agonist
Activator
General Function
Voltage-gated proton channel activity
Specific Function
NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is ...
Gene Name
NOX1
Uniprot ID
Q9Y5S8
Uniprot Name
NADPH oxidase 1
Molecular Weight
64870.455 Da
References
  1. Smith RG: An appraisal of potential drug interactions regarding hyperbaric oxygen therapy and frequently prescribed medications. Wounds. 2011 Jun;23(6):147-59. [PubMed:25881361]
  2. Prabhakar NR: Oxygen sensing by the carotid body chemoreceptors. J Appl Physiol (1985). 2000 Jun;88(6):2287-95. [PubMed:10846047]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Oxygen transporter activity
Specific Function
Involved in oxygen transport from the lung to the various peripheral tissues.
Gene Name
HBA1
Uniprot ID
P69905
Uniprot Name
Hemoglobin subunit alpha
Molecular Weight
15257.405 Da
References
  1. Miyashita H, Hashimoto K, Mohri H, Ohokubo T, Harano T, Harano K, Imai K: Hb Kanagawa [alpha 40(C5)Lys----Met]: a new alpha chain variant with an increased oxygen affinity. Hemoglobin. 1992;16(1-2):1-10. [PubMed:1634355]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Curator comments
Binding increases the affinity of other binding sites for oxygen.
General Function
Oxygen transporter activity
Specific Function
Involved in oxygen transport from the lung to the various peripheral tissues.LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.Spinorphin: functions as an...
Gene Name
HBB
Uniprot ID
P68871
Uniprot Name
Hemoglobin subunit beta
Molecular Weight
15998.34 Da
References
  1. Hamilton HB, Iuchi I, Miyaji T, Shibata S: Hemoglobin Hiroshima (beta-143 histidine--aspartic acid): a newly identified fast moving beta chain variant associated with increased oxygen affinity and compensatory erythremia. J Clin Invest. 1969 Mar;48(3):525-35. [PubMed:5773089]

Drug created on September 30, 2015 10:55 / Updated on June 16, 2019 06:59