Streptococcus pneumoniae type 6a capsular polysaccharide diphtheria crm197 protein conjugate antigen

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Streptococcus pneumoniae type 6a capsular polysaccharide diphtheria crm197 protein conjugate antigen
Accession Number
DB10296
Type
Biotech
Groups
Approved, Investigational
Biologic Classification
Vaccines
Conjugate
Description

Streptococcus pneumoniae type 6a capsular polysaccharide diphtheria crm197 protein conjugate antigen is a sterile vaccine that contains saccharides of the capsular antigens of Streptococcus pneumoniae serotype 6a individually conjugated to the CRM197 protein, a nontoxic variant of diphtheria toxin isolated from cultures of Corynebacterium diphtheriae strain C7 (β197). The saccharides in the vaccine are prepared from purified polysaccharides that are chemically activated then conjugated to the protein carrier CRM197 to form the glycoconjugate.

Synonyms
  • Streptococcus pneumoniae serotype 6A capsular antigen diphtheria CRM197 protein conjugate vaccine
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Prevnar 13Streptococcus pneumoniae type 6a capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 14 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 18c capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 19a capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 19f capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 23f capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 5 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 6b capsular polysaccharide diphtheria crm197 protein conjugate antigen (4.4 ug/0.5mL) + Streptococcus pneumoniae type 7f capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 9v capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL)Injection, suspensionIntramuscularWyeth Pharmaceutical Division of Wyeth Holdings LLC2010-03-12Not applicableUs
Prevnar 13Streptococcus pneumoniae type 6a capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 14 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 18c capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 19a capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 19f capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 23f capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 5 capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 6b capsular polysaccharide diphtheria crm197 protein conjugate antigen (4.4 ug/0.5mL) + Streptococcus pneumoniae type 7f capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL) + Streptococcus pneumoniae type 9v capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 ug/0.5mL)Injection, suspensionIntramuscularA-S Medication Solutions2010-03-12Not applicableUs
Prevnar 13Streptococcus pneumoniae type 6a capsular polysaccharide diphtheria crm197 protein conjugate antigen (2.2 mcg/0.5mL) + Corynebacterium diphtheriae (34 mcg/0.5mL) + Streptococcus pneumoniae type 1 capsular polysaccharide antigen (2.2 mcg/0.5mL) + Streptococcus pneumoniae type 14 capsular polysaccharide antigen (2.2 mcg/0.5mL) + Streptococcus pneumoniae type 18c capsular polysaccharide antigen (2.2 mcg/0.5mL) + Streptococcus pneumoniae type 19a capsular polysaccharide antigen (2.2 mcg/0.5mL) + Streptococcus pneumoniae type 19f capsular polysaccharide antigen (2.2 mcg/0.5mL) + Streptococcus pneumoniae type 23f capsular polysaccharide antigen (2.2 mcg/0.5mL) + Streptococcus pneumoniae type 3 capsular polysaccharide antigen (2.2 mcg/0.5mL) + Streptococcus pneumoniae type 4 capsular polysaccharide antigen (2.2 mcg/0.5mL) + Streptococcus pneumoniae type 5 capsular polysaccharide antigen (2.2 mcg/0.5mL) + Streptococcus pneumoniae type 6b capsular polysaccharide antigen (4.4 mcg/0.5mL) + Streptococcus pneumoniae type 7f capsular polysaccharide antigen (2.2 mcg/0.5mL) + Streptococcus pneumoniae type 9v capsular polysaccharide antigen (2.2 mcg/0.5mL)SuspensionIntramuscularPfizer Canada Ulc2010-03-01Not applicableCanada
Categories
UNII
Z9HK08690W
CAS number
Not Available

Pharmacology

Indication
Not Available
Associated Conditions
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Additional Data Available
Adverse Effects

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

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Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Substance
347910482
RxNav
901633

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedPreventionInfections, Pneumococcal1
0RecruitingPreventionAging / HIV Lipodystrophy1
0RecruitingTreatmentMultiple Myeloma (MM)1
0RecruitingTreatmentStage III Hepatocellular Carcinoma AJCC v8 / Stage III Intrahepatic Cholangiocarcinoma AJCC v8 / Stage IIIA Hepatocellular Carcinoma AJCC v8 / Stage IIIA Intrahepatic Cholangiocarcinoma AJCC v8 / Stage IIIB Hepatocellular Carcinoma AJCC v8 / Stage IIIB Intrahepatic Cholangiocarcinoma AJCC v8 / Stage IV Hepatocellular Carcinoma AJCC v8 / Stage IV Intrahepatic Cholangiocarcinoma AJCC v8 / Stage IVA Hepatocellular Carcinoma AJCC v8 / Stage IVB Hepatocellular Carcinoma AJCC v8 / Unresectable Hepatocellular Carcinoma / Unresectable Intrahepatic Cholangiocarcinoma1
1Active Not RecruitingPreventionInfections, Pneumococcal1
1CompletedPreventionInfections, Pneumococcal1
1TerminatedTreatmentMultiple Myeloma (MM)1
1, 2CompletedPreventionInfections, Pneumococcal1
1, 2CompletedPreventionInfections, Pneumococcal / Infections, Streptococcus Pneumoniae1
1, 2RecruitingOtherHealthy Volunteers1
1, 2RecruitingPreventionHealthy Volunteers / Pneumococcal Diseases1
1, 2RecruitingTreatmentAggressive Non-Hodgkin Lymphoma / Indolent Non-Hodgkin's Lymphomas / Recurrent Adult Non-Hodgkin Lymphoma / Recurrent Diffuse Large B-Cell Lymphoma / Recurrent Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Mediastinal (Thymic) Large B-Cell Cell Lymphoma / Recurrent T-Cell Non-Hodgkin Lymphoma / Small Lymphocytic Lymphoma1
2Active Not RecruitingPreventionInfections, Pneumococcal1
2Active Not RecruitingTreatmentChildhood Cancers / Multiple Diseases1
2Active Not RecruitingTreatmentChronic Lymphocytic Leukaemia (CLL) / Small Lymphocytic Lymphoma1
2CompletedPreventionInfections, Pneumococcal6
2CompletedPreventionStreptococcal Infections2
2CompletedTreatmentMonoclonal B-Cell Lymphocytosis / Stage 0 Chronic Lymphocytic Leukemia / Stage I Chronic Lymphocytic Leukemia / Stage I Small Lymphocytic Lymphoma1
2CompletedTreatmentMultiple Myeloma (MM)1
2Not Yet RecruitingPreventionSystemic Vasculitis1
2TerminatedBasic ScienceTransplant-Related Cancer1
2Unknown StatusPreventionInfectious Diseases1
2, 3Active Not RecruitingPreventionInfections, Streptococcus Pneumoniae / Invasive Pneumococcal Disease, Protection Against1
2, 3Active Not RecruitingPreventionVaccines, Pneumococcal1
3Active Not RecruitingPreventionInfections, Pneumococcal4
3Active Not RecruitingPreventionInfections, Pneumococcal / Vaccines, Pneumococcal1
3CompletedPreventionBacterial Infections / Neisseria Meningitidis / Virus Diseases1
3CompletedPreventionBacterial Infections / Virus Diseases2
3CompletedPreventionHaemophilus Influenzae Type B1
3CompletedPreventionHaemophilus Influenzae Type B / Neisseria Meningitidis1
3CompletedPreventionInfections, Pneumococcal6
3CompletedPreventionMeasles; Mumps; Rubella1
3CompletedPreventionMeningococcal Disease1
3CompletedPreventionMumps / Rubella / Rubeola2
3CompletedPreventionPneumonia1
3RecruitingPreventionInfections, Pneumococcal2
3RecruitingTreatmentInfections, Pneumococcal1
4Active Not RecruitingPreventionChronic Kidney Disease (CKD)1
4CompletedDiagnosticImmune Response / Pneumonia / Streptococcus Pneumoniae1
4CompletedPreventionDiphtheria / Meningococcal / Pertussis Diseases / Streptococcal / Tetanus1
4CompletedTreatmentEnd Stage Renal Disease (ESRD)1
4RecruitingBasic ScienceHuman Immunodeficiency Virus (HIV) Infections / Human Immunodeficiency Virus Infection(HIV)/Acquired Immunodeficiency Syndrome (AIDS) / Human Immunodeficiency Virus Type 1 (HIV-1) Infection1
4RecruitingPreventionInfections, Pneumococcal / Infections, Streptococcus Pneumoniae / Invasive Pneumococcal Disease, Protection Against1
4RecruitingPreventionPlasma Cell Neoplasms1
Not AvailableActive Not RecruitingBasic ScienceAging / Pneumonia1
Not AvailableCompletedNot AvailableInflammatory Bowel Diseases (IBD)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
Injection, suspensionIntramuscular
SuspensionIntramuscular
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Taxonomy

Classification
Not classified

Drug created on December 01, 2015 13:03 / Updated on March 01, 2020 20:38

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