Chronic Kidney Disease (CKD)

Also known as: Chronic Kidney Disease / Chronic Kidney Disease(CKD) / Chronic Kidney Diseases / Chronic Kidneys Disease / Chronic renal disease

DrugDrug NameDrug Description
DB06723Aluminum hydroxideAluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects.
DB06724Calcium CarbonateCalcium carbonate is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. Calcium carbonate may also be used as a nutritional supplement or to treat hypocalcemia.
DB00012Darbepoetin alfaHuman erythropoietin with 2 aa substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW=37 kD). Produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology.
DB00016ErythropoietinErythropoietin (EPO) is a growth factor produced in the kidneys that stimulates the production of red blood cells. It works by promoting the division and differentiation of committed erythroid progenitors in the bone marrow [FDA Label]. Epoetin alfa (Epoge) was developed by Amgen Inc. in 1983 as the first rhEPO commercialized in the United States, followed by other alfa and beta formulations. Epoetin alfa is a 165-amino acid erythropoiesis-stimulating glycoprotein produced in cell culture using recombinant DNA technology and is used for the treatment of patients with anemia associated with various clinical conditions, such as chronic renal failure, antiviral drug therapy, chemotherapy, or a high risk for perioperative blood loss from surgical procedures [FDA Label]. It has a molecular weight of approximately 30,400 daltons and is produced by mammalian cells into which the human erythropoietin gene has been introduced. The product contains the identical amino acid sequence of isolated natural erythropoietin and has the same biological activity as the endogenous erythropoietin. Epoetin alfa biosimilar, such as Retacrit (epoetin alfa-epbx or epoetin zeta), has been formulated to allow more access to treatment options for patients in the market [L2784]. The biosimilar is approved by the FDA and EMA as a safe, effective and affordable biological product and displays equivalent clinical efficacy, potency, and purity to the reference product [A7504]. Epoetin alfa formulations can be administered intravenously or subcutaneously.
DB06215FerumoxytolFerumoxytol is an intravenously administered iron preparation indicated in the EU and the US for the treatment of iron deficiency anemia in adult patients with chronic kidney disease (CKD) [A32478]. It is comprised of superparamagnetic iron oxide nanoparticles which are coated by a semi-synthetic carbohydrate shell in an isotonic, neutral pH solution that may be administered at relatively high dose by rapid intravenous injection [L2181].
DB01592IronA metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletion of iron stores may result in iron-deficiency anemia. Iron is used to build up the blood in anemia.
DB09146Iron saccharateIron saccharate (Sucroferric oxyhydroxide or Iron Sucrose) is used as a source of iron in patients with iron deficiency anemia with chronic kidney disease (CKD), including those who are undergoing dialysis (hemodialysis or peritoneal) and those who do not require dialysis. Due to less side effects than iron dextran, iron saccharate is more preferred in chronic kidney disease patients.
DB09107Methoxy polyethylene glycol-epoetin betaMethoxy polyethylene glycol-epoetin beta is a chemically synthesised Erythropoiesis Stimulating Agent (ESA) with a longer half-life than erythropoietin. ESA is used to increase synthesis of red blood cells to treat chronic kidney disease associated anemia.
DB09517Sodium ferric gluconate complexSodium ferric gluconate complex is an iron replacement product for treatment of iron deficiency anemia. The stable macromolecular complex is negatively charged at alkaline pH with an apparent molecular weight of 289,000 – 440,000 daltons on gel chromatography. It is composed of iron (III) oxide hydrate directly bonded to sucrose with a chelating gluconate function in a molar ratio of two iron molecules to one gluconate. It is used in adult and in pediatric patients over the age of 6 years with chronic kidney disease (CKD) receiving hemodialysis and receiving supplemental epoetin therapy.
DB00052SomatotropinRecombinant human growth hormone (somatotropin) 191 residues, MW 22.1 kD, synthesized in E. coli
DrugDrug NamePhaseStatusCount
DB00136Calcitriol0Completed1
DB01373Calcium0Completed1
DB00258Calcium Acetate0Completed1
DB00169Cholecalciferol0Completed1
DB00153Ergocalciferol0Completed1
DB11228Methyl cellulose0Completed1
DB00658Sevelamer0Completed1
DB11094Vitamin D0Completed1
DB06151Acetylcysteine1Unknown Status1
DB00945Acetylsalicylic acid1Unknown Status1
DB12054BQ-1231Completed1
DB05983Bardoxolone methyl1Terminated1
DB00146Calcidiol1Completed1
DB00796Candesartan cilexetil1Completed1
DB01012Cinacalcet1Completed1
DB00758Clopidogrel1Unknown Status1
DB11634Colestilan chloride1Completed1
DB00012Darbepoetin alfa1Withdrawn1
DB06410Doxercalciferol1Completed1
DB00254Doxycycline1Active Not Recruiting1
DB00700Eplerenone1Completed1
DB00016Erythropoietin1Completed2
DB09147Ferric pyrophosphate1Not Yet Recruiting1
DB00301Flucloxacillin1Suspended1
DB01005Hydroxyurea1Completed1
DB12208Iron isomaltoside 10001Completed1
DB01115Nifedipine1Completed1
DB08894Peginesatide1Completed1
DB09153Sodium Chloride1Completed1
DB01390Sodium bicarbonate1Completed1
DB01390Sodium bicarbonate1Recruiting1
DB00052Somatotropin1Completed1
DB00214Torasemide1Completed1
DB00177Valsartan1Completed1
DB09104Magnesium hydroxide1 / 2Completed1
DB04951Pirfenidone1 / 2Completed1
DB11690Vonapanitase1 / 2Completed2
DB00594Amiloride2Recruiting1
DB00026Anakinra2Recruiting1
DB06199Atrasentan2Completed3
DB05983Bardoxolone methyl2Completed2
DB05983Bardoxolone methyl2Terminated2
DB06769Bendamustine2Recruiting1
DB00188Bortezomib2Recruiting1
DB05024CTA0182Completed1
DB00169Cholecalciferol2Completed1
DB01012Cinacalcet2Terminated1
DB11672Curcumin2Recruiting1
DB06292Dapagliflozin2Recruiting1
DB00012Darbepoetin alfa2Completed1
DB00012Darbepoetin alfa2Terminated1
DB01254Dasatinib2Recruiting1
DB01234Dexamethasone2Recruiting1
DB00700Eplerenone2Completed1
DB00016Erythropoietin2Completed2
DB13995Ferric pyrophosphate citrate2Completed1
DB01029Irbesartan2Completed1
DB01592Iron2Completed1
DB06792Lanthanum carbonate2Completed1
DB00166Lipoic Acid2Completed1
DB00678Losartan2Completed1
DB01378Magnesium cation2Not Yet Recruiting1
DB00331Metformin2Recruiting1
DB09107Methoxy polyethylene glycol-epoetin beta2Completed1
DB02701Nicotinamide2Completed1
DB01115Nifedipine2Completed1
DB01115Nifedipine2Unknown Status1
DB09112Nitrous acid2Recruiting1
DB00910Paricalcitol2Completed4
DB09263Patiromer2Completed1
DB08894Peginesatide2Completed5
DB08894Peginesatide2Terminated3
DB00556Perflutren2Active Not Recruiting1
DB00556Perflutren2Recruiting1
DB01132Pioglitazone2Terminated1
DB00178Ramipril2Completed1
DB01045Rifampicin2Completed1
DB06372Rilonacept2Completed1
DB06372Rilonacept2Withdrawn1
DB04847Roxadustat2Completed2
DB00658Sevelamer2Completed6
DB06268Sitaxentan2Completed1
DB06268Sitaxentan2Unknown Status1
DB09153Sodium Chloride2Completed1
DB01390Sodium bicarbonate2Recruiting1
DB14048Sodium zirconium cyclosilicate2Completed1
DB00052Somatotropin2Completed1
DB00421Spironolactone2Completed2
DB00421Spironolactone2Recruiting1
DB01041Thalidomide2Recruiting1
DB12255Vadadustat2Completed1
DB00163Vitamin E2Completed1
DB11690Vonapanitase2Completed1
DB06629Zibotentan2Completed1
DB06151Acetylcysteine2 / 3Completed1
DB00026Anakinra2 / 3Recruiting1
DB00126Ascorbic acid2 / 3Completed1
DB00169Cholecalciferol2 / 3Completed1
DB00115Cyanocobalamin2 / 3Completed1
DB00158Folic Acid2 / 3Completed1
DB01065Melatonin2 / 3Recruiting1
DB00959Methylprednisolone2 / 3Recruiting1
DB02701Nicotinamide2 / 3Completed1
DB00910Paricalcitol2 / 3Completed1
DB00165Pyridoxine2 / 3Completed1
DB00140Riboflavin2 / 3Completed1
DB00412Rosiglitazone2 / 3Withdrawn1
DB04847Roxadustat2 / 3Enrolling by Invitation1
DB01390Sodium bicarbonate2 / 3Completed2
DB00152Thiamine2 / 3Completed1
DB00162Vitamin A2 / 3Completed1
DB06151Acetylcysteine3Completed4
DB05269Activated charcoal3Completed2
DB09278Activated charcoal3Completed2
DB00381Amlodipine3Completed1
DB00098Antithymocyte immunoglobulin (rabbit)3Completed1
DB01076Atorvastatin3Completed1
DB00993Azathioprine3Completed1
DB00146Calcidiol3Completed3
DB00136Calcitriol3Completed1
DB01373Calcium3Completed1
DB01373Calcium3Unknown Status1
DB00258Calcium Acetate3Completed1
DB00258Calcium Acetate3Unknown Status1
DB00671Cefixime3Recruiting1
DB01012Cinacalcet3Completed4
DB01012Cinacalcet3Recruiting1
DB01012Cinacalcet3Terminated1
DB00758Clopidogrel3Completed1
DB00758Clopidogrel3Recruiting1
DB11634Colestilan chloride3Completed5
DB11634Colestilan chloride3Terminated3
DB06292Dapagliflozin3Recruiting1
DB00012Darbepoetin alfa3Completed7
DB00012Darbepoetin alfa3Recruiting1
DB00012Darbepoetin alfa3Terminated2
DB09183Dasabuvir3Completed1
DB06643Denosumab3Completed1
DB06410Doxercalciferol3Completed1
DB09045Dulaglutide3Completed1
DB00700Eplerenone3Terminated1
DB00016Erythropoietin3Completed5
DB12865Etelcalcetide3Completed1
DB12865Etelcalcetide3Recruiting1
DB01590Everolimus3Recruiting2
DB01276Exenatide3Recruiting1
DB12491Fasiglifam3Withdrawn1
DB08917Ferric Carboxymaltose3Completed1
DB13949Ferric cation3Active Not Recruiting1
DB13995Ferric pyrophosphate citrate3Completed1
DB09279Fimasartan3Recruiting1
DB00695Furosemide3Recruiting1
DB11627Hepatitis B Vaccine (Recombinant)3Completed1
DB00999Hydrochlorothiazide3Completed1
DB05059ILY1013Completed3
DB00047Insulin Glargine3Completed1
DB00046Insulin Lispro3Completed1
DB01592Iron3Completed2
DB12208Iron isomaltoside 10003Completed2
DB09146Iron saccharate3Withdrawn1
DB06792Lanthanum carbonate3Active Not Recruiting1
DB06792Lanthanum carbonate3Unknown Status1
DB00678Losartan3Recruiting1
DB00959Methylprednisolone3Completed1
DB00688Mycophenolate mofetil3Recruiting1
DB01024Mycophenolic acid3Recruiting1
DB02701Nicotinamide3Active Not Recruiting1
DB00698Nitrofurantoin3Recruiting1
DB09296Ombitasvir3Completed1
DB00910Paricalcitol3Completed4
DB00910Paricalcitol3Terminated1
DB09297Paritaprevir3Completed1
DB09263Patiromer3Completed1
DB08894Peginesatide3Completed5
DB00635Prednisone3Completed1
DB00503Ritonavir3Completed1
DB00412Rosiglitazone3Terminated1
DB04847Roxadustat3Active Not Recruiting1
DB04847Roxadustat3Recruiting1
DB01104Sertraline3Completed1
DB00658Sevelamer3Completed7
DB00658Sevelamer3Terminated1
DB00641Simvastatin3Completed1
DB01390Sodium bicarbonate3Completed1
DB01390Sodium bicarbonate3Unknown Status1
DB00052Somatotropin3Terminated1
DB12713Sotagliflozin3Recruiting1
DB01015Sulfamethoxazole3Recruiting1
DB06271Sulodexide3Unknown Status1
DB00864Tacrolimus3Recruiting2
DB08816Ticagrelor3Completed1
DB08816Ticagrelor3Recruiting2
DB06212Tolvaptan3Completed1
DB00440Trimethoprim3Recruiting1
DB00177Valsartan3Completed1
DB11690Vonapanitase3Active Not Recruiting2
DB06151Acetylcysteine4Completed1
DB00945Acetylsalicylic acid4Withdrawn1
DB05269Activated charcoal4Completed2
DB09278Activated charcoal4Completed2
DB09026Aliskiren4Completed4
DB09026Aliskiren4Unknown Status1
DB00437Allopurinol4Recruiting1
DB00594Amiloride4Completed1
DB00594Amiloride4Recruiting1
DB00381Amlodipine4Recruiting1
DB00098Antithymocyte immunoglobulin (rabbit)4Completed1
DB09204Arotinolol4Active Not Recruiting1
DB00126Ascorbic acid4Recruiting1
DB00335Atenolol4Recruiting1
DB01076Atorvastatin4Active Not Recruiting1
DB01076Atorvastatin4Completed1
DB01076Atorvastatin4Terminated1
DB00074Basiliximab4Completed1
DB09231Benidipine4Not Yet Recruiting1
DB04115Berberine4Recruiting1
DB00188Bortezomib4Completed1
DB00136Calcitriol4Completed4
DB00136Calcitriol4Unknown Status1
DB01373Calcium4Terminated2
DB00258Calcium Acetate4Completed1
DB00258Calcium Acetate4Terminated1
DB08907Canagliflozin4Recruiting1
DB00796Candesartan cilexetil4Completed1
DB00796Candesartan cilexetil4Recruiting1
DB01136Carvedilol4Recruiting1
DB00310Chlorthalidone4Completed1
DB01166Cilostazol4Completed1
DB01012Cinacalcet4Completed5
DB00758Clopidogrel4Completed1
DB00758Clopidogrel4Recruiting2
DB01394Colchicine4Completed1
DB00091Cyclosporine4Completed1
DB00012Darbepoetin alfa4Completed5
DB00590Doxazosin4Recruiting1
DB06410Doxercalciferol4Completed1
DB06410Doxercalciferol4Unknown Status1
DB00584Enalapril4Recruiting1
DB00700Eplerenone4Withdrawn1
DB00153Ergocalciferol4Completed3
DB00153Ergocalciferol4Withdrawn1
DB00016Erythropoietin4Completed1
DB01590Everolimus4Completed1
DB00973Ezetimibe4Not Yet Recruiting1
DB04854Febuxostat4Recruiting1
DB13949Ferric cation4Recruiting2
DB00492Fosinopril4Not Yet Recruiting1
DB00695Furosemide4Completed1
DB00225Gadodiamide4Completed1
DB00999Hydrochlorothiazide4Completed1
DB00999Hydrochlorothiazide4Not Yet Recruiting1
DB00999Hydrochlorothiazide4Recruiting1
DB00702Icodextrin4Completed1
DB14455Influenza a virus a/california/7/2009 x-181 (h1n1) antigen (formaldehyde inactivated)4Completed1
DB00030Insulin Human4Completed1
DB01249Iodixanol4Completed1
DB01249Iodixanol4Recruiting1
DB01029Irbesartan4Recruiting1
DB01592Iron4Terminated1
DB09146Iron saccharate4Completed2
DB09146Iron saccharate4Terminated1
DB06792Lanthanum carbonate4Completed1
DB06792Lanthanum carbonate4Recruiting1
DB00528Lercanidipine4Recruiting1
DB11560Lesinurad4Recruiting1
DB00722Lisinopril4Recruiting1
DB09238Manidipine4Recruiting1
DB00603Medroxyprogesterone acetate4Completed1
DB00688Mycophenolate mofetil4Completed2
DB01024Mycophenolic acid4Completed1
DB00627Niacin4Completed1
DB01054Nitrendipine4Withdrawn1
DB00727Nitroglycerin4Recruiting1
DB00275Olmesartan4Recruiting1
DB00497Oxycodone4Recruiting1
DB00910Paricalcitol4Completed7
DB00806Pentoxifylline4Completed1
DB00790Perindopril4Completed1
DB00790Perindopril4Unknown Status1
DB01132Pioglitazone4Recruiting1
DB08860Pitavastatin4Active Not Recruiting1
DB00175Pravastatin4Recruiting1
DB00175Pravastatin4Terminated1
DB00635Prednisone4Completed1
DB00881Quinapril4Recruiting1
DB00178Ramipril4Completed2
DB00178Ramipril4Recruiting1
DB01220Rifaximin4Recruiting1
DB11738Rilmenidine4Withdrawn1
DB00728Rocuronium4Enrolling by Invitation1
DB01098Rosuvastatin4Completed1
DB01098Rosuvastatin4Not Yet Recruiting1
DB12163Sarpogrelate4Unknown Status1
DB00658Sevelamer4Completed3
DB00658Sevelamer4Terminated1
DB00641Simvastatin4Not Yet Recruiting1
DB00641Simvastatin4Unknown Status1
DB00877Sirolimus4Completed1
DB09153Sodium Chloride4Completed1
DB01390Sodium bicarbonate4Completed1
DB01390Sodium bicarbonate4Recruiting1
DB00052Somatotropin4Completed1
DB00052Somatotropin4Terminated1
DB10293Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria crm197 protein conjugate antigen4Recruiting1
DB00864Tacrolimus4Completed1
DB00966Telmisartan4Completed1
DB00966Telmisartan4Not Yet Recruiting1
DB00966Telmisartan4Recruiting1
DB08816Ticagrelor4Recruiting2
DB00177Valsartan4Completed1
DB00177Valsartan4Recruiting1
DB00177Valsartan4Unknown Status2
DB11094Vitamin D4Completed2
DB00163Vitamin E4Terminated1
DB00682Warfarin4Withdrawn1
DB03128AcetylcholineNot AvailableCompleted1
DB06151AcetylcysteineNot AvailableCompleted2
DB01436AlfacalcidolNot AvailableTerminated1
DB00437AllopurinolNot AvailableCompleted1
DB01076AtorvastatinNot AvailableCompleted2
DB12319BenzbromaroneNot AvailableNot Yet Recruiting1
DB12319BenzbromaroneNot AvailableRecruiting1
DB00136CalcitriolNot AvailableCompleted1
DB00136CalcitriolNot AvailableWithdrawn1
DB01373CalciumNot AvailableCompleted1
DB01373CalciumNot AvailableRecruiting1
DB00258Calcium AcetateNot AvailableCompleted1
DB06724Calcium CarbonateNot AvailableCompleted1
DB00169CholecalciferolNot AvailableCompleted4
DB00080DaptomycinNot AvailableCompleted1
DB00012Darbepoetin alfaNot AvailableCompleted1
DB00012Darbepoetin alfaNot AvailableTerminated1
DB11574ElbasvirNot AvailableCompleted1
DB00153ErgocalciferolNot AvailableUnknown Status1
DB00153ErgocalciferolNot AvailableWithdrawn1
DB04854FebuxostatNot AvailableCompleted1
DB04854FebuxostatNot AvailableNot Yet Recruiting1
DB04854FebuxostatNot AvailableRecruiting1
DB13949Ferric cationNot AvailableRecruiting1
DB00695FurosemideNot AvailableCompleted1
DB00695FurosemideNot AvailableRecruiting1
DB12091GadoliniumNot AvailableNot Yet Recruiting1
DB12091GadoliniumNot AvailableRecruiting1
DB01067GlipizideNot AvailableRecruiting1
DB11575GrazoprevirNot AvailableCompleted1
DB11627Hepatitis B Vaccine (Recombinant)Not AvailableCompleted1
DB00999HydrochlorothiazideNot AvailableRecruiting1
DB05059ILY101Not AvailableActive Not Recruiting1
DB01306Insulin AspartNot AvailableWithdrawn1
DB00638InulinNot AvailableWithdrawn1
DB01029IrbesartanNot AvailableRecruiting1
DB01592IronNot AvailableRecruiting1
DB06792Lanthanum carbonateNot AvailableCompleted3
DB09027LedipasvirNot AvailableActive Not Recruiting1
DB08882LinagliptinNot AvailableRecruiting1
DB00722LisinoprilNot AvailableCompleted1
DB09107Methoxy polyethylene glycol-epoetin betaNot AvailableCompleted1
DB01017MinocyclineNot AvailableActive Not Recruiting1
DB00688Mycophenolate mofetilNot AvailableCompleted1
DB00727NitroglycerinNot AvailableTerminated1
DB00368NorepinephrineNot AvailableCompleted1
DB00910ParicalcitolNot AvailableCompleted3
DB00910ParicalcitolNot AvailableTerminated1
DB00910ParicalcitolNot AvailableUnknown Status1
DB09263PatiromerNot AvailableNot Yet Recruiting1
DB01132PioglitazoneNot AvailableTerminated1
DB00178RamiprilNot AvailableRecruiting1
DB00658SevelamerNot AvailableCompleted2
DB01390Sodium bicarbonateNot AvailableCompleted1
DB01390Sodium bicarbonateNot AvailableNot Yet Recruiting1
DB09449Sodium phosphate, monobasicNot AvailableRecruiting1
DB08934SofosbuvirNot AvailableActive Not Recruiting1
DB00052SomatotropinNot AvailableCompleted2
DB00421SpironolactoneNot AvailableCompleted1
DB11094Vitamin DNot AvailableWithdrawn1