Bacillus calmette-guerin substrain connaught live antigen is intravesically administered for the treatment and prophylaxis of carcinoma in situ (CIS) of the urinary bladder and for the prophylaxis of primary or recurrent stage Ta and/or T1 papillary tumors following transurethral resection (TUR). The solution contains live, attenuated strain of Mycobacterium bovis. It is prepared from the Connaught strain of Bacillus Calmette and Guérin.

Synonyms

BCG, Live, Connaught Strain

Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
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Theracys	Injection, powder, lyophilized, for solution	81 mg/3mL	Intravesical	Sanofi Pasteur Limited	2011-07-22	2017-05-08

Additional Data Available

Application Number

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Product Code

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Categories

UNII

5H5854UBMZ

CAS number

Not Available

Pharmacology

Indication

Indicated for intravesical use in the treatment and prophylaxis of carcinoma in situ (CIS) of the urinary bladder and for the prophylaxis of primary or recurrent stage Ta and/or T1 papillary tumors following transurethral resection (TUR).

Associated Conditions

Associated Therapies

Salvage therapy

Pharmacodynamics

Not Available

Mechanism of action

Not Available

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half life

Not Available

Clearance

Not Available

Toxicity

Not Available

Affected organisms

Not Available

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Drug	Interaction
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2-Methoxyethanol	The risk or severity of infection can be increased when Bacillus calmette-guerin substrain connaught live antigen is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A	The risk or severity of infection can be increased when Bacillus calmette-guerin substrain connaught live antigen is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abacavir	The therapeutic efficacy of Bacillus calmette-guerin substrain connaught live antigen can be decreased when used in combination with Abacavir.
Abatacept	The risk or severity of infection can be increased when Bacillus calmette-guerin substrain connaught live antigen is combined with Abatacept.
Abetimus	The risk or severity of infection can be increased when Bacillus calmette-guerin substrain connaught live antigen is combined with Abetimus.
Acteoside	The risk or severity of infection can be increased when Bacillus calmette-guerin substrain connaught live antigen is combined with Acteoside.
Acyclovir	The therapeutic efficacy of Bacillus calmette-guerin substrain connaught live antigen can be decreased when used in combination with Acyclovir.
Adafosbuvir	The therapeutic efficacy of Bacillus calmette-guerin substrain connaught live antigen can be decreased when used in combination with Adafosbuvir.
Adalimumab	The risk or severity of infection can be increased when Bacillus calmette-guerin substrain connaught live antigen is combined with Adalimumab.
Adefovir	The therapeutic efficacy of Bacillus calmette-guerin substrain connaught live antigen can be decreased when used in combination with Adefovir.

Additional Data Available

Extended Description

Extended description of the mechanism of action and particular properties of each drug interaction.

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Severity

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Evidence Level

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Action

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Food Interactions

Not Available

References

General References

Not Available

External Links

PubChem Substance: 347910910

AHFS Codes

80:12.00 — Vaccines

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
3	Not Yet Recruiting	Treatment	Bladder Cancers	1
3	Recruiting	Treatment	Bladder Cancers	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage forms

Form	Route	Strength
Injection, powder, lyophilized, for solution	Intravesical	81 mg/3mL

Prices

Not Available

Patents

Not Available

Properties

State: Not Available
Experimental Properties: Not Available

Taxonomy

Classification: Not classified

Drug created on December 01, 2015 13:04 / Updated on November 14, 2019 16:36