Stannous fluoride

Identification

Name
Stannous fluoride
Accession Number
DB11092
Type
Small Molecule
Groups
Approved
Description

Stannous Fluoride, or Tn(II) Fluoride, is a compound commonly used in toothpastes for the prevention of gingivitis, dental infections, cavities, and to relieve dental hypersensitivity. Although similar in function and activity to Sodium Fluoride (NaF), the conventionally added ingredient in toothpastes, stannous fluoride has been shown to be more effective at stopping and reversing dental lesions [2]. It manages and prevents dental caries and gingivitis by promoting enamel mineralization [1], reducing gingival inflammation and bleeding [3, 4] through its potential broad-spectrum antibiotic effect and modulation of the microbial composition of the dental biofilm [2]. It is an FDA-approved over-the-counter product.

Structure
Thumb
Synonyms
  • difluorostannylene
  • fluoristan
  • tin difluoride
  • Tin(II) fluoride
Active Moieties
NameKindUNIICASInChI Key
Fluoride ionionicQ80VPU408O16984-48-8KRHYYFGTRYWZRS-UHFFFAOYSA-M
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
0.4% Stannous Fluoride Brush On GelGel0.4 %DentalPdt Image Inc. Dba Pro Dentec Canada1995-12-312009-06-15Canada
0.63% Stannous Fluor. Oral Rinse ConcentrateLiquid0.63 %DentalPdt Image Inc. Dba Pro Dentec Canada1995-12-312009-06-15Canada
1.64% Stan. Fluor. Office Rinse ConcentrateLiquid1.64 %DentalPdt Image Inc. Dba Pro Dentec Canada1995-12-311999-07-30Canada
3.28% Stannous Fluor. Irrigation ConcentrateLiquid3.28 %DentalPdt Image Inc. Dba Pro Dentec Canada1995-12-311999-07-30Canada
Alpha-dent Home Care FluorideGel0.969 mg/1gDental; OralDental Technologies, Inc.1999-12-31Not applicableUs
BurkhartGel0.116 g/120gDentalBurkhart Dental Supply Inc2013-01-05Not applicableUs
BurkhartGel0.116 g/120gDentalBurkhart Dental Supply Inc2013-01-05Not applicableUs
Crest 3D White Brilliance Daily Cleansing and Whitening SystemKit1.5 mg/1gProcter And Gamble2017-01-30Not applicableUs
Crest 3D White Brilliance Daily Cleansing and Whitening SystemKit1.5 mg/1gProcter And Gamble2015-02-05Not applicableUs
Crest Complete Multi-Benefit Extra White plus Crystal Clean anti bacPaste, dentifrice1.6 mg/1gDentalProcter And Gamble2012-08-062017-01-20Us
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Perfect Choice 0.717% Root and Dentin DesensStannous fluoride (.4 %) + Hydrogen fluoride (.14 %) + Sodium fluoride (1.09 %)LiquidDentalChallenge Products Inc.1996-08-282001-07-27Canada
PhosphotecStannous fluoride (0.4 mg/1) + Sodium pyrophosphate (40 mg/1)Injection, powder, lyophilized, for solutionIntravenousBracco Diagnostics, Inc1976-10-202007-09-30Us
Pro-dentx Comfort Dentin DesensitizerStannous fluoride (0.41 %) + Hydrogen fluoride (0.045 %) + Sodium fluoride (1.31 %)LiquidDental; OralPdt Image Inc. Dba Pro Dentec Canada1997-05-122007-10-23Canada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
BurkhartStannous fluoride (0.3408 g/284g)ConcentrateDentalBurkhart Dental Supply Inc2013-02-01Not applicableUs
BurkhartStannous fluoride (0.3408 g/284g)ConcentrateDentalBurkhart Dental Supply Inc2013-02-01Not applicableUs
FluoridexStannous fluoride (630 mg/1000mL)RinseOralDiscus Dental, Llc2005-05-112016-12-31Us
Gelato Perio Maintenance RinseStannous fluoride (0.340 g/283.5g)ConcentrateDentalMycone Dental Supply Co., Inc Dba Keystone Industries And Deepak Products Inc.2013-02-01Not applicableUs
Gelato Perio Maintenance RinseStannous fluoride (0.340 g/283.5g)ConcentrateDentalMycone Dental Supply Co., Inc Dba Keystone Industries And Deepak Products Inc.2013-02-01Not applicableUs
Pcxx 1.64 Stannous Rns MintStannous fluoride (16 1/1mg)LiquidTopicalRoss Products2015-01-01Not applicableUs
Pcxx 1.64 Stannous RnsstrawberryStannous fluoride (16 1/1mg)LiquidTopicalRoss Products2015-01-01Not applicableUs
Pcxx Snf Rns GrapeStannous fluoride (16.4 mg/1mL)RinseDental; TopicalRoss Products2017-11-24Not applicableUs
Stannous FluorideStannous fluoride (6.3 mg/1g)RinseOralCypress Pharmaceuticals, Inc.2000-03-162015-08-07Us
Categories
UNII
3FTR44B32Q
CAS number
7783-47-3
Weight
Average: 156.71
Monoisotopic: 157.899002981
Chemical Formula
F2Sn
InChI Key
ANOBYBYXJXCGBS-UHFFFAOYSA-L
InChI
InChI=1S/2FH.Sn/h2*1H;/q;;+2/p-2
IUPAC Name
difluorostannane
SMILES
F[Sn]F

Pharmacology

Indication

Indicated for use to relieve dental hypersensitivity, increase enamel production, prevent gingivitis and cavities, and control periodontal infections.

Associated Conditions
Pharmacodynamics

Stannous fluoride mediates both bactericidal and bacteriostatic properties and provides an anti-erosive action on tooth enamel.

Mechanism of action

Stannous fluoride has been shown to manage and prevent dental caries and gingivitis by promoting enamel mineralization, reducing gingival inflammation and bleeding, its potential broad-spectrum antibiotic effect, and through modulation of the microbial composition of the dental biofilm. It works by depositing a stable acid-resistant layer on the tooth surfaces which is composed of calcium fluoride produced when stannous fluoride converts the calcium mineral apatite into fluorapatite. Tin and fluoride mediate anti-erosive actions by interacting with and modifying the absorbent layer composed of salivary proteins such as mucins, perhaps by enhancing the cross-linking between the proteins to result in a more resistant and protective layer against erosion [1]. The efficacy of stannous fluoride solutions seems to depend mainly on the incorporation of tin in the mineralized dentine when the organic portion is preserved but on surface precipitation when the organic portion is continuously digested. Moreover, the relative erosion-inhibiting effects of stannous fluoride strongly depend on the presence or absence of the demineralized organic dentine matrix [6].

Absorption

Tin is retained in the demineralized organic matrix to some extent, diffuses through the phosphorylated non-collagenous proteins in the dentine called phosphophoryn and accumulates in the underlying mineralized tissue.

Volume of distribution

Stannous fluoride is cleared from saliva rapidly but very well retained in gingival plaque for a prolonged period of time [7].

Protein binding
Not Available
Metabolism
Not Available
Route of elimination

Materials introduced into the oral cavity can be eliminated by salivary washout and swallowing, absorption through oral surfaces, or degradation [7].

Half life

The half-life for the decay of the salivary elimination rate constant was 13 min [7].

Clearance

Stimulated and nonstimulated salivary elimination microrate constants in this case would be ∼1 and 0.5 min^−1, respectively [7].

Toxicity

The oral LD50 value in rats is 360mg/kg and the dermal LD50 value is >2000mg/kg. Repeated or prolonged dermal contact can cause irritant symptoms such as reddening of the skin, blisters, or dermatitis.

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. Algarni AA, Mussi MC, Moffa EB, Lippert F, Zero DT, Siqueira WL, Hara AT: The impact of stannous, fluoride ions and its combination on enamel pellicle proteome and dental erosion prevention. PLoS One. 2015 Jun 1;10(6):e0128196. doi: 10.1371/journal.pone.0128196. eCollection 2015. [PubMed:26030135]
  2. Cheng X, Liu J, Li J, Zhou X, Wang L, Liu J, Xu X: Comparative effect of a stannous fluoride toothpaste and a sodium fluoride toothpaste on a multispecies biofilm. Arch Oral Biol. 2017 Feb;74:5-11. doi: 10.1016/j.archoralbio.2016.10.030. Epub 2016 Oct 29. [PubMed:27838508]
  3. Mallatt M, Mankodi S, Bauroth K, Bsoul SA, Bartizek RD, He T: A controlled 6-month clinical trial to study the effects of a stannous fluoride dentifrice on gingivitis. J Clin Periodontol. 2007 Sep;34(9):762-7. Epub 2007 Jul 23. [PubMed:17645550]
  4. He T, Barker ML, Biesbrock A, Miner M, Amini P, Goyal CR, Qaqish J: Evaluation of anti-gingivitis benefits of stannous fluoride dentifrice among triclosan dentifrice users. Am J Dent. 2013 Aug;26(4):175-9. [PubMed:24693625]
  5. NEVITT GA, WITTER DH, BOWMAN WD: Topical applications of sodium fluoride and stannous fluoride. Public Health Rep. 1958 Sep;73(9):847-50. [PubMed:13579125]
  6. Ganss C, Hardt M, Lussi A, Cocks AK, Klimek J, Schlueter N: Mechanism of action of tin-containing fluoride solutions as anti-erosive agents in dentine - an in vitro tin-uptake, tissue loss, and scanning electron microscopy study. Eur J Oral Sci. 2010 Aug;118(4):376-84. doi: 10.1111/j.1600-0722.2010.00742.x. [PubMed:20662911]
  7. Scott DC, Coggan JW, Cruze CA, He T, Johnson RD: Topical oral cavity pharmacokinetic modeling of a stannous fluoride dentifrice: an unusual two compartment model. J Pharm Sci. 2009 Oct;98(10):3862-70. doi: 10.1002/jps.21691. [PubMed:19189400]
External Links
KEGG Drug
D05919
PubChem Compound
24550
PubChem Substance
347827893
ChemSpider
22956
ChEBI
135933
ChEMBL
CHEMBL1909079
Drugs.com
Drugs.com Drug Page
Wikipedia
Tin(II)_fluoride
ATC Codes
A01AA04 — Stannous fluoride
MSDS
Download (201 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedTreatmentDentin Sensitivity1
3CompletedTreatmentDentine Hypersensitivity5
3CompletedTreatmentOral Bacteria1
4CompletedTreatmentDental Plaque / Gingival Inflammation1
Not AvailableCompletedBasic ScienceGCF / Subgingival Plaque1
Not AvailableCompletedBasic ScienceSubgingival Plaque1
Not AvailableCompletedOtherDentin Sensitivity1
Not AvailableCompletedTreatmentGingival Inflammation1
Not AvailableCompletedTreatmentGingival Inflammation / Pregnancy1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
GelDental0.4 %
LiquidDental0.63 %
LiquidDental1.64 %
LiquidDental3.28 %
ConcentrateDental0.3408 g/284g
Paste, dentifriceDental1.4 mg/1g
Gel, dentifriceDental1.4 mg/1g
Gel, dentifriceDental1.6 mg/1g
Paste, dentifriceDental1.6 mg/1g
Kit1.5 mg/1g
Paste, dentifriceDental0.454 g/100g
Paste, dentifriceDental0.00454 g/1g
GelDental0.00400 g/1g
LiquidOral1.53 mg/1g
RinseOral630 mg/1000mL
GelDental; Topical0.4 %
GelDental; Oral0.4 %
LiquidDental; Topical1.64 %
Gel, dentifriceDental4 mg/1g
GelDental0.116 g/120g
ConcentrateDental0.340 g/283.5g
LiquidOral.71034 g/120g
Paste, dentifriceDental0.15 g/100g
Paste, dentifriceDental0.4540 g/100g
Gel, dentifriceDental0.4 mg/100g
MouthwashDental0.63 mg/100mL
GelOral4 mg/1g
Gel, dentifriceOral.4510 g/120g
Gel, dentifriceOral.45103 g/120g
KitOral6.3 mg/1mL
GelOral0.969 mg/1g
Paste, dentifriceDental; Topical.4 %
PasteDental1.10 mg/1g
LiquidTopical16 1/1mg
RinseDental; Topical16.4 mg/1mL
LiquidDental
Kit; liquidBuccal; Dental3.28 %
LiquidOral0.63 %
RinseOral1.53 mg/1g
GelDental.4 %
Injection, powder, lyophilized, for solutionIntravenous
GelDental; Oral0.969 mg/1g
GelDental; Oral4 mg/1g
GelOral1.8 g/1g
GelOral4.3 g/1g
RinseOral1.9 mg/1g
RinseOral1.9 g/1g
LiquidDental; Oral
PasteDental4.54 mg/1g
PasteDental1.5 mg/1g
PasteOral1.5 mg/1g
PasteOral1.10 mg/1g
GelOral; Topical.4 %
RinseTopical0.63 mg/1mg
GelOral1.3 mg/1mL
RinseOral6.3 mg/1g
MouthwashBuccal1.64 %
Paste, dentifriceDental4.54 mg/1g
GelOral0.4 %
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)215MSDS
boiling point (°C)850MSDS
Predicted Properties
PropertyValueSource
logP0.18ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity3 m3·mol-1ChemAxon
Polarizability2.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of inorganic compounds known as post-transition metal fluorides. These are inorganic compounds in which the largest halogen atom is fluorine, and the heaviest metal atom is a post-transition metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Post-transition metal salts
Sub Class
Post-transition metal fluorides
Direct Parent
Post-transition metal fluorides
Alternative Parents
Inorganic tin salts
Substituents
Post-transition metal fluoride / Inorganic tin salt / Inorganic salt
Molecular Framework
Not Available
External Descriptors
Not Available

Drug created on December 03, 2015 09:51 / Updated on November 02, 2018 07:06