Polyethylene glycol 300

Identification

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Name
Polyethylene glycol 300
Accession Number
DB11161
Type
Small Molecule
Groups
Approved
Description

Polyethylene glycol 300 (PEG 300) is a water-miscible polyether with an average molecular weight of 300 g/mol. It is a clear viscous liquid at room temperature with non-volatile, stable properties 1. Polyethylene glycols are widely used in biochemistry, structural biology, and medicine in addition to pharmaceutical and chemical industries. They serve as solubilizers, excipients, lubricants, and chemical reagents. Low molecular weight glycols are observed to exhibit antibacterial properties as well. PEG 300 is found in eye drops as a lubricant to temporarily relieve redness, burning and irritation of the eyes.

Synonyms
  • Macrogol 300
  • PEG 300
  • PEG-6
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Advanced Eye Relief/ Redness Instant ReliefPolyethylene glycol 300 (2 mg/1mL) + Naphazoline hydrochloride (0.1 mg/1mL)Solution / dropsOphthalmicBauch & Lomb Incorporated2010-09-13Not applicableUs
Lubricant and Redness RelieverPolyethylene glycol 300 (2 mg/1mL) + Naphazoline hydrochloride (0.1 mg/1mL)Solution / dropsOphthalmicTarget Corporation.2010-09-13Not applicableUs
Original Redness RelieverPolyethylene glycol 300 (2 mg/1mL) + Naphazoline hydrochloride (0.1 mg/1mL)Solution / dropsOphthalmicRite Aid2010-09-13Not applicableUs
Categories
UNII
5655G9Y8AQ
CAS number
25322-68-3
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication

Indicated as a lubricant in over-the-counter ophthalmic solutions to temporarily relieve redness, burning and irritation of the eyes.

Pharmacodynamics

PEGs act as nonionic surfactant to decrease surface tension and condition the stratum corneum, thus enhance the diffusion of other molecules or drugs through the skin 1.

Mechanism of action

Due to their physical properties, PEG acts as a surfactant by coating the eye. It provides lubrication and surface protection in dry eyes.

Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption

PEGs can be absorbed by the gastrointestinal tract following oral administration with the fraction absorbed being dependent on the molecular weight of the compound 1. It is likely to display minimal absorption through the intact skin, but may penetrate through injured skin with compromised barrier function 1.

Volume of distribution

No pharmacokinetic data available.

Protein binding

No pharmacokinetic data available.

Metabolism

Proportion of absorbed PEGs may be metabolized to lower oligomers, glycolic acid, hydroxyglycolic acids and the diglycolic acids homologs, carbon dioxide that is exhaled, and to a minor extent, oxalic acid 1.

Route of elimination

After oral and intravenous exposure, PEGs are excreted mainly unchanged in the urine and faeces 1.

Half life

No pharmacokinetic data available.

Clearance

No pharmacokinetic data available.

Toxicity

Oral LD50 in rat and mouse are 27500 mg/kg and 31000 mg/kg, respectively MSDS. Dermal LD50 is reported to be 20000 mg/kg in rabbit MSDS. PEGs and their derivatives are not known to cause ocular and dermal irritation, and are associated with low acute and chronic toxicities 1.

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. Fruijtier-Polloth C: Safety assessment on polyethylene glycols (PEGs) and their derivatives as used in cosmetic products. Toxicology. 2005 Oct 15;214(1-2):1-38. doi: 10.1016/j.tox.2005.06.001. [PubMed:16011869]
External Links
PubChem Substance
347911138
MSDS
Download (47.8 KB)

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
Solution / dropsOphthalmic
Prices
Not Available
Patents
Not Available

Properties

State
Liquid
Experimental Properties
PropertyValueSource
melting point (°C)-11MSDS
water solubilitySolubleMSDS
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on December 03, 2015 09:51 / Updated on June 04, 2019 07:17