Ethylene Glycols

Name
Ethylene Glycols
Accession Number
DBCAT001371
Description

An ethylene compound with two hydroxy groups (-OH) located on adjacent carbons. They are viscous and colorless liquids. Some are used as anesthetics or hypnotics. However, the class is best known for their use as a coolant or antifreeze.

Drugs
DrugDrug Description
Peginterferon alfa-2aA modified form of recombinant human interferon used to stimulate the innate antiviral response in the treatment of hepatitis B and C viruses.
Peginterferon alfa-2bA purified form of human interferon used to stimulate the innate antiviral response in the treatment of hepatitis B and C, genital warts, and some cancers.
PegaspargaseA modified form of L-asparagine amidohydrolase used to treat acute lymphoblastic leukemia, which is dependent on an external source of asparagine.
DichloralphenazoneDichloralphenazone is a sedative composed of chloral hydrate and phenazone. It is typically found in combination products Nodolor and Midrin containing isometheptene and acetaminophen used for the relief of tension...
Chloral hydrateA mild hypnotic used for experimental purposes that was previously used for the treatment of insomnia.
SP1049CIntended for the treatment of carcinoma of the oesophagus.
PEG-uricaseInvestigated for use/treatment in hyperuricemia.
LJP 1082Investigated for use/treatment in autoimmune diseases, strokes, and thrombosis.
Maxy-G34Investigated for use/treatment in adverse effects (chemotherapy) and neutropenics.
TyloxapolTyloxapol is an inhaled surfactant that assists in removing and liquefying and removing bronchopulmonary secretions with mucus and pus. Tyloxapol is administered either through nebulized solution or a stream of...
PegsunerceptInvestigated for use/treatment in rheumatoid arthritis.
Nonoxynol-9A vaginal spermicide used for the non-hormonal contraception in conjunction with other modes of contraception.
PolidocanolA sclerosing agent used for the treatment of uncomplicated spider veins and uncomplicated reticular veins, all less than 3 mm in diameter, in the lower extremity.
PeginesatidePeginesatide is used for the treatment of anemia due to chronic kidney disease (CKD) in adult patients on dialysis
Certolizumab pegolA tumor necrosis factor (TNF) blocker used to treat a variety of autoimmune and autoinflammatory conditions like Crohn's disease, rheumatoid arthritis, active psoriatic arthritis, ankylosing spondylitis, axial spondyloarthritis, and plaque psoriasis.
NaloxegolA peripherally-selective opioid antagonist used to treat opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain.
Methoxy polyethylene glycol-epoetin betaA synthetic erythropoiesis stimulating agent (ESA) used to treat anemia associated with chronic kidney disease.
Peginterferon beta-1aAn interferon beta used to treat relapsing forms of multiple sclerosis.
PegloticaseA recombinant uricase used for the treatment of chronic gout in adult patients refractory to conventional therapy.
Polyethylene glycolA laxative used to treat constipation and used for bowel preparation before colonoscopies and other procedures.
Polysorbate 80It is used as a solubilizer, antimicrobial preservative and disinfectant .
Polyethylene glycol 400An ingredient used in a wide variety of medications, and is not an approved medication.
Polyethylene glycol 300Indicated as a lubricant in over-the-counter ophthalmic solutions to temporarily relieve redness, burning and irritation of the eyes.
Polysorbate 20Polysorbate 20 is a polysorbate-type nonionic surfactant used in many commercial, household and pharmaceutical products. It is composed of 20 repeated units of polyethylene glycol via ethoxylation. Polysorbate 20 is...
Poloxamer 407Poloxamer 407 is a polyoxyethylene polymer and hydrophilic non-ionic surfactant. It consists of a central hydrophobic block of polypropylene glycol that is flanked on each side by polyethylene glycol blocks,...
Poloxamer 188A medication used to clean wounds.
PoloxaleneEthylene oxide/propylene oxide copolymer is used as a food additive. It belongs to the family of Epoxides. These are compounds containing a cyclic ether with three ring atoms (one oxygen...
Insulin peglisproNot Annotated
PegamotecanPegamotecan has been used in trials studying the treatment of Cancer of Stomach, Sarcoma, Soft Tissue, and Gastroesophageal Cancer.
Nonacog beta pegolA recombinant coagulation Factor IX derivative used to treat hemophilia B.
Antihemophilic Factor (Recombinant), PEGylatedFor the management of hemophilia A (congenital factor VIII deficiency) [FDA label], . This medication is a human antihemophilic factor indicated in adolescent and adult patients (12 years and older)...
TriglymeTriethylene glycol dimethyl ether (also called triglyme) is a glycol ether used as a solvent.
Triethylene glycolNot Available
TrichloroacetaldehydeNot Available
Calaspargase pegolAn asparagine specific enzyme used to treat acute lymphoblastic leukemia.
PegargiminaseInvestigated for use/treatment in melanoma and hepatocellular carcinoma.
Peginterferon lambda-1aPeginterferon lambda-1a is under investigation in clinical trial NCT01754974 (Safety and Efficacy Study of Peginterferon Lambda-1a vs. Peginterferon Alfa-2a, Plus Ribavirin in Subjects With Genotype 1 Hepatitis C).
Etirinotecan pegolEtirinotecan pegol is under investigation in clinical trial NCT01663012 (Phase II NKTR-102 In Bevacizumab-Resistant High Grade Glioma).
Firtecan pegolFirtecan pegol is under investigation in clinical trial NCT01036113 (A Phase 2 Study of EZN-2208 in Patients With Metastatic Breast Cancer).
Somatropin pegolSomatropin pegol is under investigation in clinical trial NCT00715689 (Dose Study in Growth Hormone Deficient Adults Investigating Safety, Pharmacokinetics and Pharmacodynamics of NNC126-0083).
Lulizumab pegolLulizumab pegol is under investigation in clinical trial NCT02843659 (Proof of Concept Study to Evaluate the Efficacy and Safety of BMS-931699 (Lulizumab) or BMS-986142 in Primary Sjögren's Syndrome).
PegfilgrastimA recombinant human granulocyte colony stimulating factor used to stimulate the production of neutrophils and prevent febrile neutropenia or infections after myelosuppressive chemotherapy.
LipegfilgrastimA medication used to reduce the duration of chemotherapy-induced neutropenia and incidence of febrile neutropenia in cytotoxic chemotherapy.
BempegaldesleukinBempegaldesleukin is under investigation in clinical trial NCT03729245 (A Study of NKTR-214 in Combination With Nivolumab Compared With the Investigator's Choice of a Tyrosine Kinase Inhibitor (TKI) Therapy (Either Sunitinib...
PegilodecakinPegilodecakin is under investigation in clinical trial NCT03382912 (Study of Pegilodecakin (LY3500518) With Nivolumab Compared to Nivolumab Alone Second-line Tx in Participants With Metastatic Non-Small Cell Lung Cancer).
PegbelferminPegbelfermin is under investigation in clinical trial NCT03486899 (A Study of Experimental Medication BMS-986036 in Adults With Nonalcoholic Steatohepatitis (NASH) and Stage 3 Liver Fibrosis).
DihydroxyphenylglycineNot Available
Drugs & Drug Targets
DrugTargetType
Peginterferon alfa-2aInterferon alpha/beta receptor 2target
Peginterferon alfa-2aInterferon alpha/beta receptor 1target
Peginterferon alfa-2aCytochrome P450 1A2enzyme
Peginterferon alfa-2bInterferon alpha/beta receptor 1target
Peginterferon alfa-2bInterferon alpha/beta receptor 2target
Peginterferon alfa-2bCytochrome P450 1A2enzyme
Peginterferon alfa-2bCytochrome P450 2D6enzyme
Peginterferon alfa-2bCytochrome P450 2C9enzyme
PegaspargaseL-asparaginetarget
PegaspargaseThyroxine-binding globulincarrier
SP1049CDNA topoisomerase 2-alphatarget
PEG-uricaseUric acid degradation bifunctional proteintarget
LJP 1082Beta-2-glycoprotein 1target
TyloxapolLipoprotein lipasetarget
Nonoxynol-9Prostaglandin G/H synthase 2enzyme
PeginesatideErythropoietin receptortarget
Certolizumab pegolTumor necrosis factortarget
Certolizumab pegolAlcohol dehydrogenase [NADP(+)]enzyme
NaloxegolCytochrome P450 3A4enzyme
NaloxegolCytochrome P450 2D6enzyme
NaloxegolCytochrome P450 2C19enzyme
NaloxegolMu-type opioid receptortarget
Methoxy polyethylene glycol-epoetin betaErythropoietin receptortarget
Peginterferon beta-1aCytochrome P450 1A2enzyme
PegloticaseUric acidtarget
Polyethylene glycolP-glycoprotein 1transporter
Polyethylene glycol 400Oxidoreductase HTATIP2target
Polyethylene glycol 400Cytochrome P450 4A11enzyme
Polyethylene glycol 400Alcohol dehydrogenase class-3enzyme
Polyethylene glycol 400Sulfotransferase 1A1enzyme
Polyethylene glycol 400Ectonucleotide pyrophosphatase/phosphodiesterase family member 1target
Polyethylene glycol 400P-glycoprotein 1transporter
Insulin peglisproCytochrome P450 1A2enzyme
Nonacog beta pegolCoagulation factor VIItarget
Nonacog beta pegolCoagulation factor VIIItarget
Nonacog beta pegolCoagulation factor Xtarget
Antihemophilic Factor (Recombinant), PEGylatedvon Willebrand factortarget
Antihemophilic Factor (Recombinant), PEGylatedvon Willebrand factorcarrier
TriglymeOuter-membrane lipoprotein LolBtarget
TriglymeProfilin-2target
TriglymeOuter-membrane lipoprotein LolBtarget
TriglymeUncharacterized proteintarget
TriglymeSerine acetyltransferasetarget
TriglymeTyrosine-protein kinase Fyntarget
TriglymePeptidyl-prolyl cis-trans isomerase F, mitochondrialtarget
TriglymeTranscriptional regulator, GntR familytarget
TriglymeABC transporter, periplasmic substrate-binding proteintarget
TriglymeTransketolasetarget
Triethylene glycolAcetolactate synthase, catabolictarget
Triethylene glycolArabinogalactan endo-1,4-beta-galactosidasetarget
Triethylene glycolPhosphoserine aminotransferasetarget
Calaspargase pegolL-asparaginetarget
PegfilgrastimGranulocyte colony-stimulating factor receptortarget
PegfilgrastimNeutrophil elastaseenzyme
LipegfilgrastimGranulocyte colony-stimulating factor receptortarget