Ethylene Glycols

An ethylene compound with two hydroxy groups (-OH) located on adjacent carbons. They are viscous and colorless liquids. Some are used as anesthetics or hypnotics. However, the class is best known for their use as a coolant or antifreeze.
DrugDrug NameDrug Description
DB00008Peginterferon alfa-2aA modified form of recombinant human interferon used to stimulate the innate antiviral response in the treatment of hepatitis B and C viruses.
DB00022Peginterferon alfa-2bA purified form of human interferon used to stimulate the innate antiviral response in the treatment of hepatitis B and C, genital warts, and some cancers.
DB00059PegaspargaseA modified form of L-asparagine amidohydrolase used to treat acute lymphoblastic leukemia, which is dependent on an external source of asparagine.
DB01495DichloralphenazoneDichloralphenazone is a sedative composed of chloral hydrate and phenazone. It is typically found in combination products Nodolor and Midrin containing isometheptene and acetaminophen used for the relief of tension...
DB01563Chloral hydrateA mild hypnotic used for experimental purposes that was previously used for the treatment of insomnia.
DB04978SP1049CIntended for the treatment of carcinoma of the oesophagus.
DB05321PEG-uricaseInvestigated for use/treatment in hyperuricemia.
DB05446LJP 1082Investigated for use/treatment in autoimmune diseases, strokes, and thrombosis.
DB05718Maxy-G34Investigated for use/treatment in adverse effects (chemotherapy) and neutropenics.
DB06439TyloxapolTyloxapol is an inhaled surfactant that assists in removing and liquefying and removing bronchopulmonary secretions with mucus and pus. Tyloxapol is administered either through nebulized solution or a stream of...
DB06611PegsunerceptInvestigated for use/treatment in rheumatoid arthritis.
DB06804Nonoxynol-9A vaginal spermicide used for the non-hormonal contraception in conjunction with other modes of contraception.
DB06811PolidocanolA sclerosing agent used for the treatment of uncomplicated spider veins and uncomplicated reticular veins, all less than 3 mm in diameter, in the lower extremity.
DB08894PeginesatidePeginesatide is used for the treatment of anemia due to chronic kidney disease (CKD) in adult patients on dialysis
DB08904Certolizumab pegolA tumor necrosis factor (TNF) blocker used to treat a variety of autoimmune and autoinflammatory conditions like Crohn's disease, rheumatoid arthritis, active psoriatic arthritis, ankylosing spondylitis, axial spondyloarthritis, and plaque psoriasis.
DB09049NaloxegolA peripherally-selective opioid antagonist used to treat opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain.
DB09107Methoxy polyethylene glycol-epoetin betaA synthetic erythropoiesis stimulating agent (ESA) used to treat anemia associated with chronic kidney disease.
DB09122Peginterferon beta-1aAn interferon beta used to treat relapsing forms of multiple sclerosis.
DB09208PegloticaseA recombinant uricase used for the treatment of chronic gout in adult patients refractory to conventional therapy.
DB09287Polyethylene glycolA laxative used to treat constipation and used for bowel preparation before colonoscopies and other procedures.
DB11063Polysorbate 80It is used as a solubilizer, antimicrobial preservative and disinfectant .
DB11077Polyethylene glycol 400An ingredient used in a wide variety of medications, and is not an approved medication.
DB11161Polyethylene glycol 300Indicated as a lubricant in over-the-counter ophthalmic solutions to temporarily relieve redness, burning and irritation of the eyes.
DB11178Polysorbate 20Polysorbate 20 is a polysorbate-type nonionic surfactant used in many commercial, household and pharmaceutical products. It is composed of 20 repeated units of polyethylene glycol via ethoxylation. Polysorbate 20 is...
DB11252Poloxamer 407Poloxamer 407 is a polyoxyethylene polymer and hydrophilic non-ionic surfactant. It consists of a central hydrophobic block of polypropylene glycol that is flanked on each side by polyethylene glycol blocks,...
DB11333Poloxamer 188A medication used to clean wounds.
DB11451PoloxaleneEthylene oxide/propylene oxide copolymer is used as a food additive. It belongs to the family of Epoxides. These are compounds containing a cyclic ether with three ring atoms (one oxygen...
DB11567Insulin peglisproNot Annotated
DB12842PegamotecanPegamotecan has been used in trials studying the treatment of Cancer of Stomach, Sarcoma, Soft Tissue, and Gastroesophageal Cancer.
DB13933Nonacog beta pegolA recombinant coagulation Factor IX derivative used to treat hemophilia B.
DB09329Antihemophilic Factor (Recombinant), PEGylatedFor the management of hemophilia A (congenital factor VIII deficiency) [FDA label], . This medication is a human antihemophilic factor indicated in adolescent and adult patients (12 years and older)...
DB02078TriglymeTriethylene glycol dimethyl ether (also called triglyme) is a glycol ether used as a solvent.
DB02327Triethylene glycolNot Available
DB02650TrichloroacetaldehydeNot Available
DB14730Calaspargase pegolAn asparagine specific enzyme used to treat acute lymphoblastic leukemia.
DB06592PegargiminaseInvestigated for use/treatment in melanoma and hepatocellular carcinoma.
DB14767Peginterferon lambda-1aPeginterferon lambda-1a is under investigation in clinical trial NCT01754974 (Safety and Efficacy Study of Peginterferon Lambda-1a vs. Peginterferon Alfa-2a, Plus Ribavirin in Subjects With Genotype 1 Hepatitis C).
DB14951Etirinotecan pegolEtirinotecan pegol is under investigation in clinical trial NCT01663012 (Phase II NKTR-102 In Bevacizumab-Resistant High Grade Glioma).
DB14953Firtecan pegolFirtecan pegol is under investigation in clinical trial NCT01036113 (A Phase 2 Study of EZN-2208 in Patients With Metastatic Breast Cancer).
DB15112Somatropin pegolSomatropin pegol is under investigation in clinical trial NCT00715689 (Dose Study in Growth Hormone Deficient Adults Investigating Safety, Pharmacokinetics and Pharmacodynamics of NNC126-0083).
DB15441Lulizumab pegolLulizumab pegol is under investigation in clinical trial NCT02843659 (Proof of Concept Study to Evaluate the Efficacy and Safety of BMS-931699 (Lulizumab) or BMS-986142 in Primary Sjögren's Syndrome).
DB00019PegfilgrastimA recombinant human granulocyte colony stimulating factor used to stimulate the production of neutrophils and prevent febrile neutropenia or infections after myelosuppressive chemotherapy.
DB13200LipegfilgrastimA medication used to reduce the duration of chemotherapy-induced neutropenia and incidence of febrile neutropenia in cytotoxic chemotherapy.
DB15140BempegaldesleukinBempegaldesleukin is under investigation in clinical trial NCT03729245 (A Study of NKTR-214 in Combination With Nivolumab Compared With the Investigator's Choice of a Tyrosine Kinase Inhibitor (TKI) Therapy (Either Sunitinib...
DB15162PegilodecakinPegilodecakin is under investigation in clinical trial NCT03382912 (Study of Pegilodecakin (LY3500518) With Nivolumab Compared to Nivolumab Alone Second-line Tx in Participants With Metastatic Non-Small Cell Lung Cancer).
DB15365PegbelferminPegbelfermin is under investigation in clinical trial NCT03486899 (A Study of Experimental Medication BMS-986036 in Adults With Nonalcoholic Steatohepatitis (NASH) and Stage 3 Liver Fibrosis).
DB04228DihydroxyphenylglycineNot Available
DrugDrug NameTargetType
DB00008Peginterferon alfa-2aInterferon alpha/beta receptor 2target
DB00008Peginterferon alfa-2aInterferon alpha/beta receptor 1target
DB00008Peginterferon alfa-2aCytochrome P450 1A2enzyme
DB00022Peginterferon alfa-2bInterferon alpha/beta receptor 1target
DB00022Peginterferon alfa-2bInterferon alpha/beta receptor 2target
DB00022Peginterferon alfa-2bCytochrome P450 1A2enzyme
DB00022Peginterferon alfa-2bCytochrome P450 2D6enzyme
DB00022Peginterferon alfa-2bCytochrome P450 2C9enzyme
DB00059PegaspargaseL-asparaginetarget
DB00059PegaspargaseThyroxine-binding globulincarrier
DB04978SP1049CDNA topoisomerase 2-alphatarget
DB05321PEG-uricaseUric acid degradation bifunctional proteintarget
DB05446LJP 1082Beta-2-glycoprotein 1target
DB06439TyloxapolLipoprotein lipasetarget
DB06804Nonoxynol-9Prostaglandin G/H synthase 2enzyme
DB08894PeginesatideErythropoietin receptortarget
DB08904Certolizumab pegolTumor necrosis factortarget
DB08904Certolizumab pegolAlcohol dehydrogenase [NADP(+)]enzyme
DB09049NaloxegolCytochrome P450 3A4enzyme
DB09049NaloxegolCytochrome P450 2D6enzyme
DB09049NaloxegolCytochrome P450 2C19enzyme
DB09049NaloxegolMu-type opioid receptortarget
DB09107Methoxy polyethylene glycol-epoetin betaErythropoietin receptortarget
DB09122Peginterferon beta-1aCytochrome P450 1A2enzyme
DB09208PegloticaseUric acidtarget
DB11077Polyethylene glycol 400Oxidoreductase HTATIP2target
DB11077Polyethylene glycol 400Cytochrome P450 4A11enzyme
DB11077Polyethylene glycol 400Alcohol dehydrogenase class-3enzyme
DB11077Polyethylene glycol 400Sulfotransferase 1A1enzyme
DB11077Polyethylene glycol 400Ectonucleotide pyrophosphatase/phosphodiesterase family member 1target
DB11077Polyethylene glycol 400P-glycoprotein 1transporter
DB11567Insulin peglisproCytochrome P450 1A2enzyme
DB13933Nonacog beta pegolCoagulation factor VIItarget
DB13933Nonacog beta pegolCoagulation factor VIIItarget
DB13933Nonacog beta pegolCoagulation factor Xtarget
DB09329Antihemophilic Factor (Recombinant), PEGylatedvon Willebrand factortarget
DB09329Antihemophilic Factor (Recombinant), PEGylatedvon Willebrand factorcarrier
DB02078TriglymeOuter-membrane lipoprotein LolBtarget
DB02078TriglymeProfilin-2target
DB02078TriglymeOuter-membrane lipoprotein LolBtarget
DB02078TriglymeUncharacterized proteintarget
DB02078TriglymeSerine acetyltransferasetarget
DB02078TriglymeTyrosine-protein kinase Fyntarget
DB02078TriglymePeptidyl-prolyl cis-trans isomerase F, mitochondrialtarget
DB02078TriglymeTranscriptional regulator, GntR familytarget
DB02078TriglymeABC transporter, periplasmic substrate-binding proteintarget
DB02078TriglymeTransketolasetarget
DB02327Triethylene glycolAcetolactate synthase, catabolictarget
DB02327Triethylene glycolArabinogalactan endo-1,4-beta-galactosidasetarget
DB02327Triethylene glycolPhosphoserine aminotransferasetarget
DB14730Calaspargase pegolL-asparaginetarget
DB00019PegfilgrastimGranulocyte colony-stimulating factor receptortarget
DB00019PegfilgrastimNeutrophil elastaseenzyme
DB13200LipegfilgrastimGranulocyte colony-stimulating factor receptortarget