Epitizide

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Epitizide
Accession Number
DB13989
Type
Small Molecule
Groups
Experimental
Description

Epitizide is a diuretic. It is often combined with triamterene.

Structure
Thumb
Synonyms
  • Epithiazide
  • Epitizidum
  • Eptizida
External IDs
P 2105 / P-2105
Categories
UNII
5B266B85J1
CAS number
1764-85-8
Weight
Average: 425.84
Monoisotopic: 424.9552316
Chemical Formula
C10H11ClF3N3O4S3
InChI Key
RINBGYCKMGDWPY-UHFFFAOYSA-N
InChI
InChI=1S/C10H11ClF3N3O4S3/c11-5-1-6-8(2-7(5)23(15,18)19)24(20,21)17-9(16-6)3-22-4-10(12,13)14/h1-2,9,16-17H,3-4H2,(H2,15,18,19)
IUPAC Name
6-chloro-1,1-dioxo-3-{[(2,2,2-trifluoroethyl)sulfanyl]methyl}-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
SMILES
NS(=O)(=O)C1=CC2=C(NC(CSCC(F)(F)F)NS2(=O)=O)C=C1Cl

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
(4R)-limoneneThe therapeutic efficacy of Epitizide can be decreased when used in combination with (4R)-limonene.
16-Bromoepiandrosterone16-Bromoepiandrosterone may increase the hypokalemic activities of Epitizide.
19-norandrostenedione19-norandrostenedione may increase the hypokalemic activities of Epitizide.
1alpha-Hydroxyvitamin D5The risk or severity of hyperkalemia can be increased when 1alpha-Hydroxyvitamin D5 is combined with Epitizide.
2,4-thiazolidinedioneThe therapeutic efficacy of 2,4-thiazolidinedione can be decreased when used in combination with Epitizide.
5-androstenedione5-androstenedione may increase the hypokalemic activities of Epitizide.
AbediterolAbediterol may increase the hypokalemic activities of Epitizide.
ABT-341The therapeutic efficacy of (1S,6R)-3-{[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]CARBONYL}-6-(2,4,5-TRIFLUOROPHENYL)CYCLOHEX-3-EN-1-AMINE can be decreased when used in combination with Epitizide.
AcarboseThe therapeutic efficacy of Acarbose can be decreased when used in combination with Epitizide.
AceclofenacThe therapeutic efficacy of Epitizide can be decreased when used in combination with Aceclofenac.
Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
14906
ChEBI
135688
ChEMBL
CHEMBL2104605
Wikipedia
Epitizide
ATC Codes
C03EA03 — Epitizide and potassium-sparing agents

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.346 mg/mLALOGPS
logP1.22ALOGPS
logP0.88ChemAxon
logS-3.1ALOGPS
pKa (Strongest Acidic)9.05ChemAxon
pKa (Strongest Basic)-3.2ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area118.36 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity85.62 m3·mol-1ChemAxon
Polarizability35.67 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on February 16, 2018 13:23 / Updated on October 01, 2018 15:41