Epitizide

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Epitizide
Accession Number
DB13989
Type
Small Molecule
Groups
Experimental
Description

Epitizide is an agent, commonly found in combination triamterene, used to produce diuresis.

Structure
Thumb
Synonyms
  • Epithiazide
  • Epitizidum
  • Eptizida
External IDs
P 2105 / P-2105
Categories
UNII
5B266B85J1
CAS number
1764-85-8
Weight
Average: 425.84
Monoisotopic: 424.9552316
Chemical Formula
C10H11ClF3N3O4S3
InChI Key
RINBGYCKMGDWPY-UHFFFAOYSA-N
InChI
InChI=1S/C10H11ClF3N3O4S3/c11-5-1-6-8(2-7(5)23(15,18)19)24(20,21)17-9(16-6)3-22-4-10(12,13)14/h1-2,9,16-17H,3-4H2,(H2,15,18,19)
IUPAC Name
6-chloro-1,1-dioxo-3-{[(2,2,2-trifluoroethyl)sulfanyl]methyl}-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
SMILES
NS(=O)(=O)C1=CC2=C(NC(CSCC(F)(F)F)NS2(=O)=O)C=C1Cl

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
1-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic AcidThe risk or severity of hypotension can be increased when Epitizide is combined with 1-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic Acid.
2,4-thiazolidinedioneThe therapeutic efficacy of 2,4-thiazolidinedione can be decreased when used in combination with Epitizide.
AbacavirEpitizide may increase the excretion rate of Abacavir which could result in a lower serum level and potentially a reduction in efficacy.
AbediterolAbediterol may increase the hypokalemic activities of Epitizide.
AcarboseThe therapeutic efficacy of Acarbose can be decreased when used in combination with Epitizide.
AceclofenacThe therapeutic efficacy of Epitizide can be decreased when used in combination with Aceclofenac.
AcemetacinThe therapeutic efficacy of Epitizide can be decreased when used in combination with Acemetacin.
AcetaminophenEpitizide may increase the excretion rate of Acetaminophen which could result in a lower serum level and potentially a reduction in efficacy.
AcetohexamideThe therapeutic efficacy of Acetohexamide can be decreased when used in combination with Epitizide.
AcetyldigitoxinThe risk or severity of adverse effects can be increased when Epitizide is combined with Acetyldigitoxin.
Additional Data Available
  • Extended Description
    Extended Description

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

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  • Action
    Evidence Level

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Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
14906
ChEBI
135688
ChEMBL
CHEMBL2104605
Wikipedia
Epitizide
ATC Codes
C03EA03 — Epitizide and potassium-sparing agents

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.346 mg/mLALOGPS
logP1.22ALOGPS
logP0.88ChemAxon
logS-3.1ALOGPS
pKa (Strongest Acidic)9.05ChemAxon
pKa (Strongest Basic)-3.2ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area118.36 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity85.62 m3·mol-1ChemAxon
Polarizability35.67 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on February 16, 2018 13:23 / Updated on May 09, 2019 00:20