Avadomide

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Avadomide
Accession Number
DB14857
Type
Small Molecule
Groups
Investigational
Description

Avadomide is under investigation in clinical trial NCT02031419 (Novel Combinations of CC-122, CC-223, CC-292, and Rituximab in Diffuse Large B-cell Lymphoma and Follicular Lymphoma).

Structure
Thumb
Synonyms
Not Available
External IDs
CC-122
Categories
UNII
28DZS29F59
CAS number
1015474-32-4
Weight
Average: 286.291
Monoisotopic: 286.106590327
Chemical Formula
C14H14N4O3
InChI Key
RSNPAKAFCAAMBH-UHFFFAOYSA-N
InChI
InChI=1S/C14H14N4O3/c1-7-16-9-4-2-3-8(15)12(9)14(21)18(7)10-5-6-11(19)17-13(10)20/h2-4,10H,5-6,15H2,1H3,(H,17,19,20)
IUPAC Name
3-(5-amino-2-methyl-4-oxo-3,4-dihydroquinazolin-3-yl)piperidine-2,6-dione
SMILES
CC1=NC2=C(C(N)=CC=C2)C(=O)N1C1CCC(=O)NC1=O

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
35521266
BindingDB
76986
ChEMBL
CHEMBL3989934

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1Active Not RecruitingTreatmentDiffuse B-Cell Lymphoma1
1Active Not RecruitingTreatmentGlioblastomas / Lymphoma, Large B-Cell, Diffuse (DLBCL) / Malignant Lymphomas / Multiple Myeloma (MM) / Pleiotropic Pathway Modifier / Primary Central Nervous System Lymphoma (PCNSL)1
1Active Not RecruitingTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL)1
1Active Not RecruitingTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL) / Non-Hodgkin's Lymphoma (NHL)1
1Active Not RecruitingTreatmentNon-Hodgkin's Lymphoma (NHL)1
1CompletedNot AvailableClinical Pharmacology, Healthy Male Volunteer Study1
1CompletedNot AvailableHealthy Volunteers1
1CompletedTreatmentHealthy Volunteers1
1CompletedTreatmentImpaired kidney function1
1TerminatedTreatmentHepatocellular,Carcinoma1
1, 2Active Not RecruitingTreatmentLeukemia, Lymphocytic, Chronic, B-Cell1
1, 2CompletedTreatmentHepatocellular,Carcinoma1
1, 2RecruitingTreatmentFollicular Lymphoma (FL) / Lymphoma, Large B-Cell, Diffuse (DLBCL) / Non-Hodgkin's Lymphoma (NHL)1
2RecruitingTreatmentMelanoma1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.355 mg/mLALOGPS
logP0.06ALOGPS
logP-0.083ChemAxon
logS-2.9ALOGPS
pKa (Strongest Acidic)11.61ChemAxon
pKa (Strongest Basic)5.39ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area104.86 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity77.1 m3·mol-1ChemAxon
Polarizability28.19 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on May 20, 2019 08:31 / Updated on March 01, 2020 21:57

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