25-desacetylrifapentine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
25-desacetylrifapentine
Accession Number
DB15213
Type
Small Molecule
Groups
Investigational
Description

25-desacetylrifapentine is under investigation in clinical trial NCT00023387 (TBTC Study 25PK: Intensive Pharmacokinetic Study of Three Doses of Rifapentine and 25-Desacetyl Rifapentine).

Structure
Thumb
Synonyms
  • 25-DESACETYL RIFAPENTINE
Categories
UNII
29A0K44SJO
CAS number
79039-56-8
Weight
Average: 835.008
Monoisotopic: 834.441508832
Chemical Formula
C45H62N4O11
InChI Key
LPUNEQQTZOWCNO-WEOUFWGLSA-N
InChI
InChI=1S/C45H62N4O11/c1-23-12-11-13-24(2)44(57)47-35-30(22-46-49-19-17-48(18-20-49)29-14-9-10-15-29)40(54)32-33(41(35)55)39(53)28(6)42-34(32)43(56)45(7,60-42)59-21-16-31(58-8)25(3)37(51)27(5)38(52)26(4)36(23)50/h11-13,16,21-23,25-27,29,31,36-38,50-55H,9-10,14-15,17-20H2,1-8H3,(H,47,57)/b12-11-,21-16-,24-13-,46-22+/t23-,25+,26+,27-,31-,36-,37+,38+,45-/m0/s1
IUPAC Name
SMILES
CO[C@H]1C=CO[C@@]2(C)OC3=C(C2=O)C2=C(O)C(\C=N\N4CCN(CC4)C4CCCC4)=C(NC(=O)\C(C)=C/C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](O)[C@@H]1C)C(O)=C2C(O)=C3C

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
(R)-warfarinThe risk or severity of bleeding can be increased when 25-desacetylrifapentine is combined with (R)-warfarin.
(S)-WarfarinThe risk or severity of bleeding can be increased when 25-desacetylrifapentine is combined with (S)-Warfarin.
4-hydroxycoumarinThe risk or severity of bleeding can be increased when 25-desacetylrifapentine is combined with 4-hydroxycoumarin.
AcebutololThe metabolism of Acebutolol can be increased when combined with 25-desacetylrifapentine.
AcenocoumarolThe risk or severity of bleeding can be increased when 25-desacetylrifapentine is combined with Acenocoumarol.
Adenovirus type 7 vaccine liveThe therapeutic efficacy of Adenovirus type 7 vaccine live can be decreased when used in combination with 25-desacetylrifapentine.
AlprenololThe metabolism of Alprenolol can be increased when combined with 25-desacetylrifapentine.
AnisodamineThe metabolism of Anisodamine can be increased when combined with 25-desacetylrifapentine.
Anthrax immune globulin humanThe therapeutic efficacy of Anthrax immune globulin human can be decreased when used in combination with 25-desacetylrifapentine.
Anthrax vaccineThe therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with 25-desacetylrifapentine.
Additional Data Available
  • Extended Description
    Extended Description

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  • Severity
    Severity

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  • Evidence Level
    Evidence Level

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  • Action
    Action

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Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
23976039

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
Not AvailableCompletedTreatmentTuberculosis Infection1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on May 20, 2019 09:00 / Updated on May 21, 2019 12:38