- Lactams, Macrocyclic
- Accession Number
LACTAMS forming compounds with a ring size of approximately 1-3 dozen atoms.
Drug Drug Description Rifabutin An antibiotic used to treat mycobacterium avium complex disease in patients with HIV. Rifampicin An antibiotic used to treat several types of mycobacterial infections including Mycobacterium avium complex, leprosy, and in combination with other antibacterials to treat latent or active tuberculosis. Rifapentine An antibiotic agent used in the treatment of pulmonary tuberculosis. Rifaximin A rifamycin-based non-systemic antibiotic used for the treatment of gastrointestinal bacterial infections, such as traveler's diarrhea and irritable bowel syndrome, and reduction of overt hepatic encephalopathy recurrence in adults. Rifalazil Investigated for use/treatment in atherosclerosis, bacterial infection, and peripheral vascular disease. Trastuzumab emtansine An antineoplastic agent and antibody-drug conjugate used to treat HER2-overexpressing breast cancer. AVE9633 Investigated for use/treatment in leukemia (myeloid). Coltuximab ravtansine Investigated for use/treatment in lymphoma (non-hodgkin's). Lorvotuzumab mertansine Lorvotuzumab mertansine has been used in trials studying the treatment of SCLC, Leukemia, Ovarian Cancer, Multiple Myeloma, and Merkel Cell Carcinoma, among others. Mirvetuximab Soravtansine Mirvetuximab Soravtansine has been used in trials studying the treatment of Ovarian cancer, Endometrial Cancer, Fallopian tube cancer, Epithelial Ovarian Cancer, and Primary Peritoneal Cancer, among others. CGP 4832 Not Available Rifamycin An antibacterial used to treat traveler's diarrhea. Anetumab ravtansine Anetumab ravtansine is under investigation in clinical trial NCT03455556 (Anetumab Ravtansine and Atezolizumab in Treating Participants With Advanced Non-small Cell Lung Cancer). 25-desacetylrifapentine 25-desacetylrifapentine is under investigation in clinical trial NCT00023387 (TBTC Study 25PK: Intensive Pharmacokinetic Study of Three Doses of Rifapentine and 25-Desacetyl Rifapentine).
- Drugs & Drug Targets