Ambroxol is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. It is the active ingredient of Mucosolvan, Lasolvan or Mucoangin. The substance is a mucoactive drug with several properties including secretolytic and secretomotoric actions that restore the physiological clearance mechanisms of the respiratory tract which play an important role in the body’s natural defence mechanisms. It stimulates synthesis and release of surfactant by type II pneumocytes. Surfactants acts as an anti-glue factor by reducing the adhesion of mucus to the bronchial wall, in improving its transport and in providing protection against infection and irritating agents.
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|Weight||Average: 378.108 |
Ambroxol is indicated as “secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport. It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe freely and deeply.
|Structured Indications||Not Available|
|Mechanism of action|
Ambroxol is a mucolytic agent. Excessive Nitric oxide (NO) is associated with inflammatory and some other disturbances of airways function. NO enhances the activation of soluble guanylate cyclase and cGMP accumulation. Ambroxol has been shown to inhibit the NO-dependent activation of soluble guanylate cyclase. It is also possible that the inhibition of NO-dependent activation of soluble guanylate cyclase can suppress the excessive mucus secretion, therefore it lowers the phlegm viscosity and improves the mucociliary transport of bronchial secretions.
Rapid and almost complete.
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Kack, J., Koss, F.W., Schraven, E. and Beisenherz, G.; US. Patent 3,536,713; October 27, 1970; assigned to Boehringer lngelheim G.m.b.H.
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|ATC Codes||R05CB06 — Ambroxol|
|AHFS Codes||Not Available|
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|FDA label||Not Available|
|MSDS||Download (47.4 KB)|
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|Description||This compound belongs to the class of organic compounds known as phenylmethylamines. These are compounds containing a phenylmethtylamine moiety, which consists of a phenyl group substituted by an methanamine.|
|Class||Benzene and substituted derivatives|
|Alternative Parents||Benzylamines / 2-bromoanilines / Cyclohexylamines / Cyclohexanols / Bromobenzenes / Aralkylamines / Aryl bromides / Cyclic alcohols and derivatives / Dialkylamines / Primary amines / Organopnictogen compounds / Organobromides / Hydrocarbon derivatives|
|Substituents||Benzylamine / Aniline or substituted anilines / 2-bromoaniline / Phenylmethylamine / Bromobenzene / Aralkylamine / Cyclohexanol / Cyclohexylamine / Halobenzene / Aryl bromide/ Aryl halide / Cyclic alcohol / Secondary alcohol / Secondary amine / Secondary aliphatic amine / Organonitrogen compound / Amine / Organooxygen compound / Primary amine / Alcohol / Hydrocarbon derivative / Organopnictogen compound / Organic oxygen compound / Organic nitrogen compound / Organohalogen compound / Organobromide / Aromatic homomonocyclic compound|
|Molecular Framework||Aromatic homomonocyclic compounds|
|External Descriptors||Not Available|
- Pharmacological action
- General Function:
- Vitamin d3 25-hydroxylase activity
- Specific Function:
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
- Gene Name:
- Uniprot ID:
- Uniprot Name:
- Cytochrome P450 3A4
- Molecular Weight:
- 57342.67 Da
- Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]