NAV

CYNK-001

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
CYNK-001
DrugBank Accession Number
DB15722
Background

CYNK-001 is a novel allogenic off-the-shelf natural killer (NK) cell therapy originating from human placental CD34+ hematopoietic stem cells and enriched with CD56+/CD3-.

Type
Biotech
Groups
Investigational
Biologic Classification
Cell transplant therapies
Other cell transplant therapies
Synonyms
Not Available
External IDs
  • CYNK-001
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action

CYNK-001 has the potential to inhibit viral infection by killing host cells through indirect immune responses. CYNK-001 expresses NKG2D and DNAM-1 receptors in addition to cytotoxicity receptors NKp30, NKp44, and NKp46. These receptors bind to the ligands and antigens expressed on infected cells, and initiate the release of perforin and granzyme B from the NK cell to induce cell death. In addition to being investigated for the treatment of acute myeloid leukemia, multiple myeloma, and glioblastoma multiforme, CYNK-001 is also being investigated for treating COVID-19.

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
Not Available
CAS number
Not Available

References

General References
  1. Zhang J, Xie B, Hashimoto K: Current status of potential therapeutic candidates for the COVID-19 crisis. Brain Behav Immun. 2020 Jul;87:59-73. doi: 10.1016/j.bbi.2020.04.046. Epub 2020 Apr 22. [Article]
  2. Lifespan: CELULARITY INC. – CYNK-001 [Link]
  3. Oncology Nursing News: Novel Cancer Agent To Be Investigated for Coronavirus Treatment [Link]
Not Available

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1Active Not RecruitingTreatmentAnalgesia / Analgesics, Non-Narcotic / Antineoplastic Agents / Cardiovascular Disease (CVD) / Hematologic Disease and Disorders / Hemorrhagic Disorders / Hemostatic Disorders / Immune System Diseases / Immunoproliferative Disorders / Lymphoproliferative Disorders / Multiple Myeloma (MM) / Neoplasm / Neoplasms by Histologic Type / Paraproteinemias / Peripheral Nervous System Agents / Physiological Effects of Drugs / Plasma Cell Neoplasms / Protein Disorder, Blood / Sensory System Agents / Vascular Diseases1
1RecruitingTreatmentAcute Myeloid Leukemia / Alkylating Agents / Analgesia / Analgesics, Non-Narcotic / Anti-Infective Agents / Antimetabolites, Antineoplastic / Antiviral Agents / Hematologic Disease and Disorders / Immunologic Factors / Immunosuppressive Agents / Leukemia in Remission / Leukemias / Myeloid Leukemias / Neoplasm / Neoplasms by Histologic Type / Neoplasms, Hematologic / Peripheral Nervous System Agents / Physiological Effects of Drugs / Refractory Acute Myeloid Leukemia (AML) / Relapsed Adult Acute Myeloid Leukemia1
1TerminatedTreatmentAnalgesia / Analgesics, Non-Narcotic / Anti-Infective Agents / Antiviral Agents / Astrocytoma, Grade IV / Cyclophosphamide / Giant Cell Glioblastoma / Glioblastoma Multiforme (GBM) / Immunologic Factors / Immunosuppressive Agents / Molecular Mechanisms of Pharmacological Action / Peripheral Nervous System Agents / Physiological Effects of Drugs / Sensory System Agents1
1, 2Active Not RecruitingTreatmentAcute Respiratory Distress Syndrome (ARDS) / Analgesia / Anti-Infective Agents / Antimetabolites, Antineoplastic / Antiviral Agents / Coronaviridae Infections / Coronavirus Disease 2019 (COVID‑19) / Immunologic Diseases / Immunologic Factors / Infections, Coronavirus / Lung Disorder / Nidovirales Infections / Physiological Effects of Drugs / Pneumonia / Respiratory Tract Diseases / Respiratory Tract Infections (RTI) / Severe Acute Respiratory Syndrome Coronavirus 2 / Viral Disease / Viral Pneumonia / Virus Infection, RNA1
1, 2WithdrawnTreatmentAstrocytoma, Grade IV / Giant Cell Glioblastoma / Glioblastoma Multiforme (GBM) / High Grade Glioma: Glioblastoma (GBM)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created at August 11, 2020 18:08 / Updated at August 13, 2020 07:02