Anaphylaxis

Also known as: Anaphylactic shock / Anaphylactic reaction / Allergic shock / Systemic anaphylaxis / Systemic anaphylactic reaction

DrugDrug NameDrug Description
DB00748CarbinoxamineCarbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the counter cough and cold medicine is being modified to state "do not use" in children under 4 years of age in order to prevent and reduce misuse, as many unapproved carbinoxamine-containing preparations contained inappropriate labeling, which promoted unapproved uses (including management of congestion, cough, the common cold, and the use in children under 2 years of age), which can potentially cause serious health risks.
DB00434CyproheptadineA serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc. [PubChem]
DB01075DiphenhydramineDiphenhydramine, also known commercially as Benadryl, is a first generation antihistamine that is used primarily for the treatment of seasonal allergies. However, it also has antiemetic, antitussive, hypnotic, and antiparkinson properties. As histamine receptors exist both peripherally and in the central nervous system, diphenhydramine has been shown to cause sedation due to its competitive antagonism of histamine H1 receptors within the central nervous system. While its use in in allergies has largely fallen out of favour due to this sedative effect, diphenhydramine has been repurposed for use within many OTC (over the counter) cough-and-cold medications that have been marketed for "night time" use. Diphenhydramine is also used in combination with [DB14132] as the anti-nausea drug [DB00985] where it is utilized primarily for its antagonism of H1 histamine receptors within the vestibular system [A1540]. Diphenhydramine has also been shown to be implicated in a number of neurotransmitter systems that affect behaviour including dopamine, norepinephrine, serotonin, acetylcholine, and opioid [A1539]. As a result, diphenhydramine is being investigated for its anxiolytic and anti-depressant properties.
DB00668EpinephrineThe active sympathomimetic hormone from the adrenal medulla in most species. It stimulates both the alpha- and beta- adrenergic systems, causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels. It is used in asthma and cardiac failure and to delay absorption of local anesthetics. [PubChem]
DrugDrug NameTargetType
DB00748CarbinoxamineHistamine H1 receptortarget
DB00748CarbinoxamineCytochrome P450 2B6enzyme
DB00748CarbinoxamineCytochrome P450 2C19enzyme
DB00748CarbinoxamineCytochrome P450 2C8enzyme
DB00748CarbinoxamineCytochrome P450 2C9enzyme
DB00748CarbinoxamineCytochrome P450 2D6enzyme
DB00748CarbinoxamineCytochrome P450 2E1enzyme
DB00748CarbinoxamineCytochrome P450 3A4enzyme
DB00434Cyproheptadine5-hydroxytryptamine receptor 2Atarget
DB00434CyproheptadineHistamine H1 receptortarget
DB00434CyproheptadineMuscarinic acetylcholine receptor M1target
DB00434CyproheptadineMuscarinic acetylcholine receptor M2target
DB00434CyproheptadineMuscarinic acetylcholine receptor M3target
DB00434Cyproheptadine5-hydroxytryptamine receptor 2Ctarget
DB00434CyproheptadineUDP-glucuronosyltransferase 1-3enzyme
DB00434Cyproheptadine5-hydroxytryptamine receptor 7target
DB01075DiphenhydramineHistamine H1 receptortarget
DB01075DiphenhydramineCytochrome P450 2D6enzyme
DB01075DiphenhydramineCytochrome P450 1A2enzyme
DB01075DiphenhydramineCytochrome P450 2C9enzyme
DB01075DiphenhydramineCytochrome P450 2C19enzyme
DB01075DiphenhydramineCytochrome P450 2C18enzyme
DB01075DiphenhydramineCytochrome P450 2B6enzyme
DB01075DiphenhydramineSolute carrier family 22 member 2transporter
DB01075DiphenhydramineSolute carrier family 22 member 1transporter
DB01075DiphenhydramineSolute carrier family 22 member 5transporter
DB01075DiphenhydramineProstaglandin G/H synthase 1enzyme
DB01075DiphenhydramineMuscarinic acetylcholine receptor M2target
DB00668EpinephrineAlpha-1A adrenergic receptortarget
DB00668EpinephrineBeta-1 adrenergic receptortarget
DB00668EpinephrineBeta-2 adrenergic receptortarget
DB00668EpinephrinePhenylalanine-4-hydroxylasetarget
DB00668EpinephrineSolute carrier family 22 member 2transporter
DB00668EpinephrineSolute carrier family 22 member 1transporter
DB00668EpinephrineSolute carrier family 22 member 5transporter
DB00668EpinephrineCytochrome P450 1A2enzyme
DB00668EpinephrineCytochrome P450 2C9enzyme
DB00668EpinephrineCytochrome P450 3A4enzyme
DB00668EpinephrineAlpha-1B adrenergic receptortarget
DB00668EpinephrineAlpha-1D adrenergic receptortarget
DB00668EpinephrineAlpha-2A adrenergic receptortarget
DB00668EpinephrineAlpha-2B adrenergic receptortarget
DB00668EpinephrineAlpha-2C adrenergic receptortarget
DB00668EpinephrineBeta-3 adrenergic receptortarget
DB00668EpinephrineTumor necrosis factortarget
DB00668EpinephrineSuperoxide dismutase [Cu-Zn]target
DrugDrug NamePhaseStatusCount
DB06206Sugammadex1Completed1
DB00668Epinephrine2Active Not Recruiting1
DB00043Omalizumab2Active Not Recruiting1
DB00668Epinephrine4Recruiting1
DB00668EpinephrineNot AvailableCompleted1
DB01109HeparinNot AvailableWithdrawn1
DB09153Sodium ChlorideNot AvailableWithdrawn1