Identification

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Name
Dexamethasone
Accession Number
DB01234  (APRD00674)
Type
Small Molecule
Groups
Approved, Investigational, Vet approved
Description

An anti-inflammatory 9-fluoro-glucocorticoid.

Structure
Thumb
Synonyms
  • 1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone
  • 1-Dehydro-16α-methyl-9α-fluorohydrocortisone
  • 16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol
  • 16α-Methyl-9α-fluoro-1-dehydrocortisol
  • 9alpha-Fluoro-16alpha-methylprednisolone
  • 9α-Fluoro-16α-methylprednisolone
  • Dexametasona
  • Dexaméthasone
  • Dexamethasone
  • Dexamethasonum
External IDs
ISV-305 / NSC-34521 / OTO-104
Product Ingredients
IngredientUNIICASInChI Key
Dexamethasone phosphate2BP70L44PR312-93-6VQODGRNSFPNSQE-CXSFZGCWSA-N
Dexamethasone sodium phosphateAI9376Y64P2392-39-4PLCQGRYPOISRTQ-UHFFFAOYSA-L
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Accufix II Dec Model 033-212ImplantTelectronics Pacing Systems Inc.1994-12-311999-08-27Canada
DecadronTablet0.5 mg/1OralMerck Sharp & Dohme Limited1958-10-302007-11-30Us
DecadronTablet0.75 mg/1OralMerck Sharp & Dohme Limited1958-10-302007-11-30Us
Decadron Phosphate Eye Ear Sol 0.1%LiquidAuricular (otic); OphthalmicMerck Frosst Canada & Cie, Merck Frosst Canada & Co.1960-12-311998-04-21Canada
Decadron Phosphate Inj 4mg/mlLiquidIntramuscular; IntravenousMerck Frosst Canada & Cie, Merck Frosst Canada & Co.1959-12-312001-08-01Canada
Decadron Tab 0.5mgTabletOralMerck Frosst Canada & Cie, Merck Frosst Canada & Co.1958-12-312002-07-29Canada
Decadron Tab 4mgTabletOralMerck Frosst Canada & Cie, Merck Frosst Canada & Co.1976-12-312003-08-08Canada
DexamethasoneSolution0.1 %Auricular (otic); OphthalmicPharma Stulln Inc.1994-12-31Not applicableCanada
Dexamethasone Omega UnidoseSolutionIntramuscular; Intrasynovial; IntravenousOmega Laboratories Ltd2013-05-08Not applicableCanada
Dexamethasone Sod Phos Inj 4mg/mlLiquidIntramuscular; IntravenousTaro Pharmaceuticals, Inc.1989-12-312001-08-21Canada
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-dexamethasoneTabletOralApotex Corporation2004-03-08Not applicableCanada
Apo-dexamethasoneTabletOralApotex Corporation2004-11-17Not applicableCanada
BaycadronElixir0.5 mg/5mLOralWockhardt1983-07-27Not applicableUs
DecadronTablet0.75 mg/1OralPragma Pharmaceuticals, LLC2018-02-28Not applicableUs
DecadronTablet0.5 mg/1OralPragma Pharmaceuticals, LLC2018-02-28Not applicableUs
DecadronTablet6 mg/1OralPragma Pharmaceuticals, LLC2018-02-28Not applicableUs
DecadronTablet1.5 mg/1OralWraser Llc2017-09-112017-09-25Us
DecadronTablet4 mg/1OralPragma Pharmaceuticals, LLC2018-02-28Not applicableUs
DecadronElixir0.5 mg/5mLOralPragma Pharmaceuticals, LLC2018-03-15Not applicableUs
Decadron DPTablet1.5 mg/1OralXspire Pharma, Llc2017-09-112017-09-25Us
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
999 Itch ReliefDexamethasone (15 mg/20000mg) + Levomenthol (200 mg/20000mg) + Synthetic camphor (200 mg/20000mg)OintmentTopicalChina Resources Sanjiu Medical & Pharmaceutical Co., Ltd.2003-07-03Not applicableUs
AK-TrolDexamethasone (1 mg/1g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (10000 [USP'U]/1g)OintmentOphthalmicPhysicians Total Care, Inc.1996-01-052000-06-30Us
CiprodexDexamethasone (1 mg/1mL) + Ciprofloxacin hydrochloride (3 mg/1mL)Suspension / dropsAuricular (otic)Nucare Pharmaceuticals,inc.2003-08-04Not applicableUs
CiprodexDexamethasone (1 mg/1mL) + Ciprofloxacin hydrochloride (3 mg/1mL)SuspensionAuricular (otic)Physicians Total Care, Inc.2004-09-21Not applicableUs
CiprodexDexamethasone (1 mg/1mL) + Ciprofloxacin hydrochloride (3 mg/1mL)SuspensionAuricular (otic)Rebel Distributors2003-08-15Not applicableUs
CiprodexDexamethasone (1 mg/1mL) + Ciprofloxacin hydrochloride (3 mg/1mL)Suspension / dropsAuricular (otic)Clinical Solutions Wholsesale2003-08-152017-06-28Us
CiprodexDexamethasone (0.1 %) + Ciprofloxacin (0.3 %)SuspensionAuricular (otic)Novartis2004-05-13Not applicableCanada
CiprodexDexamethasone (1 mg/1mL) + Ciprofloxacin hydrochloride (3 mg/1mL)Suspension / dropsAuricular (otic)Proficient Rx LP2003-08-04Not applicableUs
CiprodexDexamethasone (1 mg/1mL) + Ciprofloxacin hydrochloride (3 mg/1mL)Suspension / dropsAuricular (otic)ALCON LABORATORIES, INC.2003-08-04Not applicableUs
Cortaren Corticosteroid/Anti-Inflammatory SystemDexamethasone sodium phosphate (4 mg/1mL) + Bupivacaine hydrochloride monohydrate (5 mg/1mL) + Isopropyl alcohol (0.7 mL/1mL) + Triamcinolone acetonide (40 mg/1mL)KitTopicalIt3 Medical Llc2017-03-01Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Dex-MoxiDexamethasone sodium phosphate (1 mg/1mL) + Moxifloxacin hydrochloride monohydrate (5 mg/1mL)Injection, solutionOphthalmicImprimis Njof, Llc2018-01-05Not applicableUs
Dex-Moxi PFDexamethasone sodium phosphate (1 mg/1mL) + Moxifloxacin hydrochloride monohydrate (5 mg/1mL)Injection, solutionIntraocularImprimisRx NJ2018-01-01Not applicableUs
Dex-Moxi-KetorDexamethasone sodium phosphate (1 mg/1mL) + Ketorolac tromethamine (0.4 mg/1mL) + Moxifloxacin hydrochloride monohydrate (0.5 mg/1mL)Injection, solutionOphthalmicImprimis Njof, Llc2018-01-05Not applicableUs
Dexamethasone Sodium Phosphate 0.1% / Finasteride 0.1% / Minoxidil 5%Dexamethasone sodium phosphate (0.1 g/100g) + Finasteride (0.1 g/100g) + Minoxidil (5 g/100g)SolutionTopicalSincerus Florida, LLC2019-05-09Not applicableUs
Dexamethasone Sodium Phosphate 0.1% / Finasteride 0.1% / Minoxidil 5% / Tretinoin 0.025%Dexamethasone sodium phosphate (0.1 g/100g) + Finasteride (0.1 g/100g) + Minoxidil (5 g/100g) + Tretinoin (0.025 g/100g)SolutionTopicalSincerus Florida2019-05-09Not applicableUs
Dexlido KitDexamethasone sodium phosphate (10 mg/1mL) + Isopropyl alcohol (70 mL/100mL) + Lidocaine hydrochloride (10 mg/1mL) + Povidone-iodine (10 mg/1mL)KitTopicalAsclemed Usa, Inc.2014-07-25Not applicableUs
Dexlido-M KitDexamethasone sodium phosphate (10 mg/1mL) + Bupivacaine hydrochloride monohydrate (2.5 mg/1mL) + Isopropyl alcohol (70 mL/100mL) + Lidocaine hydrochloride (10 mg/1mL) + Povidone-iodine (10 mg/1mL)KitTopicalAsclemed Usa, Inc.2014-07-25Not applicableUs
DexMoxiKetor PFDexamethasone sodium phosphate (1 mg/1mL) + Ketorolac tromethamine (0.4 mg/1mL) + Moxifloxacin hydrochloride monohydrate (0.5 mg/1mL)Injection, solutionIntraocularImprimisRx NJ2018-01-01Not applicableUs
DexopinDexamethasone sodium phosphate (10 mg/1mL) + Povidone-iodine (10 mg/1mL) + Ropivacaine hydrochloride (5 mg/1mL)KitTopicalAsclemed Usa, Inc.2019-06-10Not applicableUs
Dmt SuikDexamethasone sodium phosphate (10 mg/1mL)Injection, solutionIntramuscular; IntravenousAsclemed Usa, Inc.2003-05-29Not applicableUs
Categories
UNII
7S5I7G3JQL
CAS number
50-02-2
Weight
Average: 392.4611
Monoisotopic: 392.199902243
Chemical Formula
C22H29FO5
InChI Key
UREBDLICKHMUKA-CXSFZGCWSA-N
InChI
InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
IUPAC Name
(1R,2R,3aS,3bS,9aS,9bR,10S,11aS)-9b-fluoro-1,10-dihydroxy-1-(2-hydroxyacetyl)-2,9a,11a-trimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one
SMILES
[H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C

Pharmacology

Indication

Injection: for the treatment of endocrine disorders, rheumatic disorders, collagen diseases, dermatologic diseases, allergic statesc, ophthalmic diseases, gastrointestinal diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, cerebral edema.
Ophthalmic ointment and solution: for the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe.
Ophthalmic solution only: for the treatment of steroid responsive inflammatory conditions of the external auditory meatus
Topic cream: for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses
Oral aerosol: for the treatment of bronchial asthma and related corticosteroid responsive bronchospastic states intractable to adequate trial of conventional therapy
Intranasal aerosol: for the treatment of allergic ot inflammatory nasal conditions, and nasal polyps

Associated Conditions
Pharmacodynamics

Dexamethasone and its derivatives, dexamethasone sodium phosphate and dexamethasone acetate, are synthetic glucocorticoids. Used for its antiinflammatory or immunosuppressive properties and ability to penetrate the CNS, dexamethasone is used alone to manage cerebral edema and with tobramycin to treat corticosteroid-responsive inflammatory ocular conditions.

Mechanism of action

Dexamethasone is a glucocorticoid agonist. Unbound dexamethasone crosses cell membranes and binds with high affinity to specific cytoplasmic glucocorticoid receptors. This complex binds to DNA elements (glucocorticoid response elements) which results in a modification of transcription and, hence, protein synthesis in order to achieve inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of dexamethasone are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.

TargetActionsOrganism
AGlucocorticoid receptor
agonist
Humans
UNuclear receptor subfamily 0 group B member 1
stimulator
Humans
UAnnexin A1
agonist
Humans
UNitric oxide synthase, inducible
negative modulator
Humans
UNuclear receptor subfamily 1 group I member 2Not AvailableHumans
Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption

80-90%

Volume of distribution
Not Available
Protein binding

70%

Metabolism

Hepatic.

Route of elimination
Not Available
Half life

36-54 hours

Clearance
Not Available
Toxicity

Oral, rat LD50: >3 gm/kg. Signs of overdose include retinal toxicity, glaucoma, subcapsular cataract, gastrointestinal bleeding, pancreatitis, aseptic bone necrosis, osteoporosis, myopathies, obesity, edemas, hypertension, proteinuria, diabetes, sleep disturbances, psychiatric syndromes, delayed wound healing, atrophy and fragility of the skin, ecchymosis, and pseudotumor cerebri.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
(R)-warfarinThe metabolism of (R)-warfarin can be increased when combined with Dexamethasone.
(S)-WarfarinThe metabolism of (S)-Warfarin can be increased when combined with Dexamethasone.
1-TestosteroneThe risk or severity of edema formation can be increased when 1-Testosterone is combined with Dexamethasone.
1,10-PhenanthrolineThe therapeutic efficacy of 1,10-Phenanthroline can be decreased when used in combination with Dexamethasone.
16-BromoepiandrosteroneThe risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Dexamethasone.
19-norandrostenedioneThe risk or severity of edema formation can be increased when 19-norandrostenedione is combined with Dexamethasone.
1alpha-Hydroxyvitamin D5The therapeutic efficacy of 1alpha-Hydroxyvitamin D5 can be decreased when used in combination with Dexamethasone.
1alpha,24S-Dihydroxyvitamin D2The therapeutic efficacy of 1alpha,24S-Dihydroxyvitamin D2 can be decreased when used in combination with Dexamethasone.
2-MethoxyethanolThe risk or severity of adverse effects can be increased when Dexamethasone is combined with 2-Methoxyethanol.
2,4-thiazolidinedioneThe therapeutic efficacy of 2,4-thiazolidinedione can be decreased when used in combination with Dexamethasone.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

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  • Action
    Action

    An effect category for each drug interaction. Know how this interaction affects the subject drug.

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Food Interactions
  • Avoid alcohol.
  • Avoid taking with grapefruit juice.
  • Take with food to reduce irritation.

References

Synthesis Reference

Fried, J.; US. Patent 2,852.51 1; September 16, 1958; assigned to Olin Mathieson Chemical Corporation. Muller, G., Bardoneschi, R. and Jolly, J.; U.S. Patent 3,007,923; November 7, 1961; assigned to Les Laboratories Francais de Chimiotherapie, France.

General References
Not Available
External Links
Human Metabolome Database
HMDB0015364
KEGG Drug
D00292
KEGG Compound
C15643
PubChem Compound
5743
PubChem Substance
46508930
ChemSpider
5541
BindingDB
18207
ChEBI
41879
ChEMBL
CHEMBL384467
Therapeutic Targets Database
DAP000007
PharmGKB
PA449247
Guide to Pharmacology
GtP Drug Page
HET
DEX
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
PDRhealth
PDRhealth Drug Page
Wikipedia
Dexamethasone
ATC Codes
R01AD53 — Dexamethasone, combinationsD07XB05 — DexamethasoneS03BA01 — DexamethasoneR01AD03 — DexamethasoneD10AA03 — DexamethasoneS01CB01 — DexamethasoneS02CA06 — Dexamethasone and antiinfectivesS03CA01 — Dexamethasone and antiinfectivesC05AA09 — DexamethasoneD07CB04 — Dexamethasone and antibioticsH02AB02 — DexamethasoneS01BA01 — DexamethasoneA01AC02 — DexamethasoneS01CA01 — Dexamethasone and antiinfectivesD07AB19 — DexamethasoneS02BA06 — Dexamethasone
AHFS Codes
  • 68:04.00 — Adrenals
  • 52:08.00 — Anti-inflammatory Agents
  • 52:08.08 — Corticosteroids
PDB Entries
1m2z / 1p93 / 3gn8 / 3mne / 3mno / 3mnp / 4uda / 4udc
FDA label
Download (96 KB)
MSDS
Download (74.8 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0Active Not RecruitingBasic ScienceMultiple Myeloma (MM)1
0Active Not RecruitingPreventionDistal Radius Fractures / Osteoarthritis (OA)1
0CompletedBasic SciencePlasma Cell Myeloma1
0CompletedSupportive CareNausea / Vomiting1
0CompletedTreatmentImpacted Third Molar Tooth1
0CompletedTreatmentPrecursor Cell Lymphoblastic Leukemia-Lymphoma1
0Not Yet RecruitingTreatmentBlepharo Conjunctivitis1
0Not Yet RecruitingTreatmentPsoriasis / Psoriasis Vulgaris (Plaque Psoriasis) / Skin Diseases1
0RecruitingBasic ScienceSleep Restriction1
0RecruitingPreventionSurgery, Hand1
0RecruitingSupportive CareLower Limb Injury1
0RecruitingTreatmentCesarean Section1
0RecruitingTreatmentNK-Cell Leukemia / NK-Cell Lymphoma / Peripheral T Cell Lymphoma (PTCL)1
0RecruitingTreatmentOral Lichen Planus1
0TerminatedTreatmentMultiple Myeloma (MM)1
0WithdrawnBasic ScienceBMI >30 kg/m2 / Hyperandrogenemia / Polycystic Ovaries Syndrome1
1Active Not RecruitingOtherMultiple Myeloma (MM)1
1Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL)1
1Active Not RecruitingTreatmentAntenatal Corticosteroids / Premature Births1
1Active Not RecruitingTreatmentCholangiocarcinomas / Neoplasms, Hepatic1
1Active Not RecruitingTreatmentCholangiocellular Carcinoma) (ICC) / Cholangiolar Carcinoma / Intrahepatic Cholangiocarcinoma / Peripheral Cholangiocarcinoma1
1Active Not RecruitingTreatmentColorectal Cancers / Metastatic Cancers1
1Active Not RecruitingTreatmentDiseases of Oesophagus Stomach and Duodenum1
1Active Not RecruitingTreatmentHaematological Malignancies / Plasma Cell Myeloma1
1Active Not RecruitingTreatmentHigh Risk Smoldering Multiple Myeloma / Multiple Myeloma (MM)1
1Active Not RecruitingTreatmentHodgkins Disease (HD) / Lymphoma, Large B-Cell, Diffuse (DLBCL) / Lymphoma, T-Cell, Cutaneous / Lymphoma, T-Cell, Peripheral1
1Active Not RecruitingTreatmentImpaired Renal Function / Multiple Myeloma (MM)1
1Active Not RecruitingTreatmentLight Chain Deposition Disease / Primary Systemic Amyloidosis1
1Active Not RecruitingTreatmentLymphoma, Hodgkins / Refractory / Relapses1
1Active Not RecruitingTreatmentMalignant Lymphomas1
1Active Not RecruitingTreatmentMultiple Myeloma (MM)11
1Active Not RecruitingTreatmentMultiple Myeloma (MM) / Plasma Cell Myeloma1
1Active Not RecruitingTreatmentMultiple Myeloma (MM) / Relapsed and/or Refractory Multiple Myeloma1
1Active Not RecruitingTreatmentMultiple Myeloma in Relapse1
1Active Not RecruitingTreatmentPlasma Cell Myeloma / Recurrent Plasma Cell Myeloma / Refractory Plasma Cell Myeloma1
1Active Not RecruitingTreatmentRecurrent Plasma Cell Myeloma / Refractory Plasma Cell Myeloma1
1Active Not RecruitingTreatmentRelapsed or Refractory Acute Myeloid Leukemia / Relapsed Or Refractory Multiple Myeloma1
1CompletedNot AvailablePostoperative pain1
1CompletedBasic ScienceHealthy Volunteers1
1CompletedBasic ScienceStress1
1CompletedDiagnosticCaudal Block1
1CompletedDiagnosticHealthy Volunteers / Lean1
1CompletedDiagnosticPulmonary Nodules1
1CompletedHealth Services ResearchCoarctation of the Aorta1
1CompletedOtherInduction of Labor Affected Fetus / Newborn1
1CompletedOtherMultiple Myeloma (MM)1
1CompletedPreventionChemotherapy-Induced Nausea and Vomiting (CINV) / Healthy Volunteers1
1CompletedPreventionLacrimation increased1
1CompletedTreatmentAcute Lymphoblastic Leukaemias (ALL) / Hodgkins Disease (HD) / Non-Hodgkin's Lymphoma (NHL)1
1CompletedTreatmentAcute Lymphoid Leukemia Relapse / Acute Lymphoid Leukemia Relapse After Bone Marrow Transplant1
1CompletedTreatmentAdnexal Masses / Borderline Ovarian Epithelial Tumor / Neoplasms, Ovarian / Ovarian Clear Cell Tumor / Ovarian Endometrioid Tumor / Ovarian Serous Tumor / Recurrent Ovarian Carcinoma1
1CompletedTreatmentAdvanced Cancer, Various, NOS1
1CompletedTreatmentAdvanced Malignancies / Cancer, Advanced1
1CompletedTreatmentAll / Blast Crisis / Leukemia Acute Myeloid Leukemia (AML) / Multiple Myeloma (MM) / Smith-Magenis Syndrome1
1CompletedTreatmentAmyloidosis / Systemic Light Chain Amyloidosis1
1CompletedTreatmentB-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma and Burkitt Lymphoma / Central Nervous System Lymphoma / Intraocular Lymphoma / Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System / Recurrent Adult Diffuse Large Cell Lymphoma / Retinal Lymphoma1
1CompletedTreatmentBronchiolitis1
1CompletedTreatmentChemotherapy-Induced Nausea and Vomiting (CINV)1
1CompletedTreatmentChildhood B Acute Lymphoblastic Leukemia / Childhood T Acute Lymphoblastic Leukemia / Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Lymphoblastic Lymphoma1
1CompletedTreatmentColorectal Cancers / Metastatic Cancers1
1CompletedTreatmentEye Dryness1
1CompletedTreatmentGraves' Disease1
1CompletedTreatmentHead and Neck Carcinoma1
1CompletedTreatmentHealthy Volunteers3
1CompletedTreatmentHepatic Insufficiency / Neoplasm Metastases1
1CompletedTreatmentHodgkins Disease (HD) / Multiple Myeloma (MM) / Non-Hodgkin's Lymphoma (NHL) / Waldenström's Macroglobulinemia (WM)1
1CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Non-Hodgkin's Lymphoma (NHL)1
1CompletedTreatmentKnee Osteoarthritis (Knee OA)1
1CompletedTreatmentLeptomeningeal Metastases1
1CompletedTreatmentLeukemia, Acute / Lymphoma, Hodgkins / Non-Hodgkin's Lymphoma (NHL)1
1CompletedTreatmentLeukemias2
1CompletedTreatmentLeukemias / Malignant Lymphomas1
1CompletedTreatmentLivers / Nasopharyngeal Carcinoma / Neoplasms Metastasis1
1CompletedTreatmentLymphoblastic Leukemia, Acute T-cell / Precursor T-Cell Lymphoblastic Lymphoma1
1CompletedTreatmentLymphoma, B-Cell1
1CompletedTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL) / Multiple Myeloma (MM) / Non-Hodgkin's Lymphoma (NHL) / Other B-cell NHL Subtypes, Including WM / T-cell NHL / Waldenström's Macroglobulinemia (WM)1
1CompletedTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL) / Peripheral T-Cell Lymphoma (PTCL)1
1CompletedTreatmentLymphoma, Low-Grade / Lymphoma, Mixed-Cell, Follicular / Lymphoma, Small Cleaved-Cell, Follicular / Small Lymphocytic Lymphoma (SLL)1
1CompletedTreatmentMalignancies1
1CompletedTreatmentMalignancies, Hematologic1
1CompletedTreatmentMalignancies / Neoplasms1
1CompletedTreatmentMalignant Lymphomas2
1CompletedTreatmentMenière's Disease1
1CompletedTreatmentMesothelioma1
1CompletedTreatmentMultiple Myeloma (MM)20
1CompletedTreatmentMultiple Myeloma (MM) / Multiple Myeloma in Relapse / Refractory Multiple Myeloma1
1CompletedTreatmentMultiple Myeloma (MM) / Non-Hodgkin's Lymphoma (NHL)1
1CompletedTreatmentMultiple Myeloma (MM) / Non-Hodgkin's Lymphoma (NHL) / Tumors, Solid1
1CompletedTreatmentMultiple Myeloma and Plasma Cell Neoplasm1
1CompletedTreatmentMultiple Myeloma, Plasma Cell Leukemia1
1CompletedTreatmentNeoplasms / Neoplasms by Histologic Type / Neoplasms, Connective and Soft Tissue / Sarcomas / Soft Tissue Sarcoma (STS)1
1CompletedTreatmentNon-infectious, Non-necrotizing Anterior Scleritis1
1CompletedTreatmentPain NOS1
1CompletedTreatmentPlasma Cell Myeloma2
1CompletedTreatmentProstate Cancer1
1CompletedTreatmentRecurrent Plasma Cell Myeloma1
1CompletedTreatmentRecurrent Plasma Cell Myeloma / Refractory Plasma Cell Myeloma1
1CompletedTreatmentRefractory Multiple Myeloma / Stage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
1CompletedTreatmentRelapsed Multiple Myeloma1
1CompletedTreatmentRelapsed Or Refractory Multiple Myeloma1
1CompletedTreatmentRelapsed/Refractory Multiple Myeloma1
1CompletedTreatmentStatus Asthmaticus1
1CompletedTreatmentTumors1
1CompletedTreatmentTumors, Solid1
1CompletedTreatmentUnspecified Adult Solid Tumor, Protocol Specific2
1CompletedTreatmentVitrectomy therapy1
1Enrolling by InvitationTreatmentMyelodysplastic Syndromes1
1Not Yet RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / All / ALL, Childhood1
1Not Yet RecruitingTreatmentBronchiolitis; Respiratory Syncytial Virus1
1Not Yet RecruitingTreatmentEffect of Drugs1
1Not Yet RecruitingTreatmentLumbar Disc Rupture / Lumbosacral Radiculopathy / Sciatica1
1Not Yet RecruitingTreatmentMultiple Myeloma (MM)1
1RecruitingBasic ScienceSleep Restriction1
1RecruitingOtherMultiple Myeloma (MM)1
1RecruitingPreventionMigraine1
1RecruitingTreatmentALL, Childhood / Lymphoblastic Leukemia, Acute, Childhood / Lymphoblastic Lymphoma, Childhood1
1RecruitingTreatmentAcute Lymphoblastic Leukaemia Recurrent / Refractory Acute Lymphoblastic Leukemia1
1RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL)2
1RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / B-cell Non Hodgkin's Lymphoma / Pre B-Cell Acute Lymphoblastic Leukaemia1
1RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Leukemia Acute Myeloid Leukemia (AML) / Untreated Adult Acute Myeloid Leukemia1
1RecruitingTreatmentAcute Lymphoblastic Leukemia ALL1
1RecruitingTreatmentAcute Lymphoblastic Leukemia With Failed Remission / Acute Lymphoblastic Leukemia, in Relapse1
1RecruitingTreatmentAmyloid Light Chain (AL) Amyloidosis / Hematopoietic/Lymphoid Cancer / Newly Diagnosed Primary Amyloidosis / Recurrent Primary Amyloidosis / Refractory Primary Amyloidosis1
1RecruitingTreatmentAnalgesia1
1RecruitingTreatmentCancer, Breast / Prostate Cancer1
1RecruitingTreatmentContiguous Stage II Adult Lymphoblastic Lymphoma / Noncontiguous Stage II Adult Lymphoblastic Lymphoma / Stage I Adult Lymphoblastic Lymphoma / Stage III Adult Lymphoblastic Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Untreated Adult Acute Lymphoblastic Leukemia1
1RecruitingTreatmentExudative Retinal Detachment and Uveal Melanoma1
1RecruitingTreatmentHaematological Malignancies / Plasma Cell Myeloma1
1RecruitingTreatmentHigh Altitude Cerebral Edema1
1RecruitingTreatmentHypercalcemia / Plasmacytoma / Recurrent Plasma Cell Myeloma / Refractory Plasma Cell Myeloma1
1RecruitingTreatmentLymphoma, B-Cell1
1RecruitingTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL)1
1RecruitingTreatmentMetastatic Colorectal Cancers1
1RecruitingTreatmentMild -Moderate Anaphylaxis - Symptoms That Affect the Skin With Cardiovascular, Respiratory or Gastrointestinal Involvement, But no Signs of Hypotension ,Laryng1
1RecruitingTreatmentMultiple Myeloma (MM)8
1RecruitingTreatmentMultiple Myeloma (MM) / Multiple Myeloma in Relapse / Refractory Multiple Myeloma1
1RecruitingTreatmentNeoplasms Malignant1
1RecruitingTreatmentRecurrent B Acute Lymphoblastic Leukemia / Refractory B Acute Lymphoblastic Leukemia1
1RecruitingTreatmentRecurrent Diffuse Large B-Cell Lymphoma / Refractory Diffuse Large B Cell Lymphoma1
1RecruitingTreatmentRecurrent Plasma Cell Myeloma1
1RecruitingTreatmentRecurrent Plasma Cell Myeloma / Refractory Plasma Cell Myeloma1
1RecruitingTreatmentRefractory Diabetic Macular Edema1
1RecruitingTreatmentRefractory Multiple Myeloma1
1RecruitingTreatmentRelapsed Or Refractory Multiple Myeloma1
1RecruitingTreatmentRetinoblastoma1
1RecruitingTreatmentVitiligo1
1SuspendedTreatmentAL Amyloidosis1
1SuspendedTreatmentAnemias / Hypercalcemia / Lytic Bone Lesion / Osteopenia / Pathologic fracture / Recurrent Plasma Cell Myeloma / Refractory Plasma Cell Myeloma1
1SuspendedTreatmentCongestive Heart Failure (CHF)1
1SuspendedTreatmentRecurrent Plasma Cell Myeloma1
1TerminatedTreatmentAcute Lymphoblastic Leukaemia Recurrent / Allergy to Native e.Coli Asparaginase / Allergy to PEG e.Coli Asparaginase1
1TerminatedTreatmentAcute Lymphoblastic Leukaemias (ALL) / Recurrent Pediatric ALL / Refractory Pediatric ALL / Relapsed Pediatric ALL1
1TerminatedTreatmentCancer, Breast1
1TerminatedTreatmentCataracts1
1TerminatedTreatmentChemotherapy-Induced Nausea and Vomiting (CINV)1
1TerminatedTreatmentChildhood Atypical Teratoid/Rhabdoid Tumor / Childhood Central Nervous System Choriocarcinoma / Childhood Central Nervous System Germinoma / Childhood Central Nervous System Mixed Germ Cell Tumor / Childhood Central Nervous System Teratoma / Childhood Central Nervous System Yolk Sac Tumor / Childhood Choroid Plexus Tumor / Childhood Craniopharyngioma / Childhood Ependymoblastoma / Childhood Grade I Meningioma / Childhood Grade II Meningioma / Childhood Grade III Meningioma / Childhood Infratentorial Ependymoma / Childhood Medulloepithelioma / Childhood Mixed Glioma / Childhood Oligodendroglioma / Childhood Supratentorial Ependymoma / Gonadotroph Adenoma / Pituitary Basophilic Adenoma / Pituitary Chromophobe Adenoma / Pituitary Eosinophilic Adenoma / Prolactin Secreting Adenoma / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Anaplastic Large Cell Lymphoma / Recurrent Childhood Brain Stem Glioma / Recurrent Childhood Central Nervous System Embryonal Tumor / Recurrent Childhood Cerebellar Astrocytoma / Recurrent Childhood Cerebral Astrocytoma / Recurrent Childhood Ependymoma / Recurrent Childhood Grade III Lymphomatoid Granulomatosis / Recurrent Childhood Large Cell Lymphoma / Recurrent Childhood Lymphoblastic Lymphoma / Recurrent Childhood Medulloblastoma / Recurrent Childhood Pineoblastoma / Recurrent Childhood Small Noncleaved Cell Lymphoma / Recurrent Childhood Spinal Cord Neoplasm / Recurrent Childhood Subependymal Giant Cell Astrocytoma / Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor / Recurrent Childhood Visual Pathway and Hypothalamic Glioma / Recurrent Childhood Visual Pathway Glioma / Recurrent Pituitary Tumor / Recurrent/Refractory Childhood Hodgkin Lymphoma / T-cell Childhood Acute Lymphoblastic Leukemia / T-Cell Large Granular Lymphocyte Leukemia / TSH Secreting Adenoma / Unspecified Childhood Solid Tumor, Protocol Specific1
1TerminatedTreatmentLeukemias1
1TerminatedTreatmentLymphoid Hematological Malignancies / Multiple Myeloma (MM) / Refractory Multiple Myeloma / Relapsed and Refractory Multiple Myeloma / Relapsed Multiple Myeloma1
1TerminatedTreatmentMixed Phenotype Acute Leukemia (MPAL) / Relapsed or Refractory Acute Lymphoblastic Leukemia / Relapsed or Refractory Lymphoblastic Lymphoma1
1TerminatedTreatmentMultiple Myeloma (MM)5
1TerminatedTreatmentMultiple Myeloma and Plasma Cell Neoplasm1
1TerminatedTreatmentPlasma Cell Myeloma2
1TerminatedTreatmentRecurrent Childhood Anaplastic Astrocytoma / Recurrent Childhood Anaplastic Oligoastrocytoma / Recurrent Childhood Anaplastic Oligodendroglioma / Recurrent Childhood Giant Cell Glioblastoma / Recurrent Childhood Glioblastoma / Recurrent Childhood Gliomatosis Cerebri / Recurrent Childhood Gliosarcoma1
1TerminatedTreatmentRotator Cuff Syndrome1
1TerminatedTreatmentWaldenström's Macroglobulinemia (WM)1
1Unknown StatusTreatmentLateral Epicondylitis (Tennis Elbow)1
1WithdrawnTreatmentLeukemia, Plasma Cell1
1WithdrawnTreatmentMS Patient With Relpasing Remitting Attacks1
1WithdrawnTreatmentMalignant Lymphomas1
1WithdrawnTreatmentMalignant Lymphomas / Neoplasms, Brain / Sarcoma, Osteogenic / Sarcomas / Wilms' tumor1
1WithdrawnTreatmentMalignant Neoplasms Stated as Primary Lymphoid Haematopoietic / Multiple Myeloma (MM)1
1WithdrawnTreatmentMultiple Myeloma (MM)2
1WithdrawnTreatmentTraumas1
1, 2Active Not RecruitingTreatmentAL Amyloidosis1
1, 2Active Not RecruitingTreatmentCancer of the Ovary / Lung Cancer Non-Small Cell Cancer (NSCLC) / Lung Cancer Small Cell Lung Cancer (SCLC) / Malignant Lymphomas / Multiple Myeloma (MM) / Renal Cancers / Tumors, Solid1
1, 2Active Not RecruitingTreatmentCognitive Side Effects of Cancer Therapy / Neurotoxicity Syndrome / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Small Lymphocytic Lymphoma / Therapy-Related Toxicity / Tiredness / Waldenström's Macroglobulinemia (WM)1
1, 2Active Not RecruitingTreatmentDS Stage I Plasma Cell Myeloma / DS Stage II Plasma Cell Myeloma / DS Stage III Plasma Cell Myeloma / Multiple Myeloma (MM) / Plasma Cell Myeloma1
1, 2Active Not RecruitingTreatmentEsophageal Cancers1
1, 2Active Not RecruitingTreatmentGeneral Surgery / Pelvic Organ Prolapse (POP) / Postoperative pain1
1, 2Active Not RecruitingTreatmentHaematological Malignancies1
1, 2Active Not RecruitingTreatmentKahler Disease / Multiple Myeloma (MM) / Myeloma, Plasma-Cell / Plasma Cell Myeloma1
1, 2Active Not RecruitingTreatmentLeptomeningeal Metastasis1
1, 2Active Not RecruitingTreatmentLeukemia Acute Myeloid Leukemia (AML) / Leukemias / Myelodysplastic Syndrome1
1, 2Active Not RecruitingTreatmentLung Cancers1
1, 2Active Not RecruitingTreatmentLymphoma, Hodgkins / Multiple Myeloma (MM) / Non-Hodgkin's Lymphoma (NHL)1
1, 2Active Not RecruitingTreatmentMalignant Lymphomas / Mantle Cell Lymphoma (MCL)1
1, 2Active Not RecruitingTreatmentMultiple Myeloma (MM)24
1, 2Active Not RecruitingTreatmentMultiple Myeloma (MM) / Relapsed/Refractory Multiple Myeloma1
1, 2Active Not RecruitingTreatmentMultiple Myeloma-Light Chain Only / Plasma Cell Myeloma / Recurrent Plasma Cell Myeloma / Refractory Plasma Cell Myeloma1
1, 2Active Not RecruitingTreatmentOtitis Media (OM) / Otorrhoea1
1, 2Active Not RecruitingTreatmentRecurrent Plasma Cell Myeloma / Refractory Plasma Cell Myeloma1
1, 2Active Not RecruitingTreatmentRefractory Multiple Myeloma2
1, 2Active Not RecruitingTreatmentRelapsed and/or Relapsed-refractory Multiple Myeloma1
1, 2CompletedHealth Services ResearchMultiple Myeloma (MM)1
1, 2CompletedPreventionHigh Altitude Pulmonary Edema1
1, 2CompletedSupportive CareNeovascular Age-Related Macular Degeneration1
1, 2CompletedTreatmentAcute Lymphoblastic Leukaemias (ALL)2
1, 2CompletedTreatmentAcute Lymphoblastic Leukaemias (ALL) / Acute Lymphocytic Leukemia (ALL)1
1, 2CompletedTreatmentAcute Lymphocytic Leukemia (ALL) / Leukemias1
1, 2CompletedTreatmentAcute Undifferentiated Leukemia (AUL) / B-cell Adult Acute Lymphoblastic Leukemia / B-cell Childhood Acute Lymphoblastic Leukemia / L1 Adult Acute Lymphoblastic Leukemia / L1 Childhood Acute Lymphoblastic Leukemia / L2 Adult Acute Lymphoblastic Leukemia / L2 Childhood Acute Lymphoblastic Leukemia / Philadelphia Chromosome Negative Adult Precursor Acute Lymphoblastic Leukemia / Philadelphia Chromosome Positive Adult Precursor Acute Lymphoblastic Leukemia / Philadelphia Chromosome Positive Childhood Precursor Acute Lymphoblastic Leukemia / T-cell Adult Acute Lymphoblastic Leukemia / T-cell Childhood Acute Lymphoblastic Leukemia / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
1, 2CompletedTreatmentAdvanced Cancers / Malignant Lymphomas1
1, 2CompletedTreatmentAdvanced Malignancies / Cancer, Advanced / Metastatic Cancers / Tumors, Solid1
1, 2CompletedTreatmentAmyloidosis1
1, 2CompletedTreatmentBranch Retinal Vein Occlusion / Macular Degeneration / Macular Edema (ME)1
1, 2CompletedTreatmentChronic Lymphocytic Leukaemia (CLL)1
1, 2CompletedTreatmentDiabetic Macular Edema (DME)1
1, 2CompletedTreatmentIndolent Plasma Cell Myeloma / Plasma Cell Myeloma / Smoldering Plasma Cell Myeloma1
1, 2CompletedTreatmentInflammation Eye1
1, 2CompletedTreatmentLeukemia, Plasma Cell / Multiple Myeloma (MM)1
1, 2CompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
1, 2CompletedTreatmentMacular Edema (ME) / Retinal Vein Occlusions(RVO)1
1, 2CompletedTreatmentMalignant Lymphomas1
1, 2CompletedTreatmentMultiple Myeloma (MM)15
1, 2CompletedTreatmentMultiple Myeloma (MM) / Multiple Myeloma in Relapse1
1, 2CompletedTreatmentMultiple Myeloma (MM) / Stage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
1, 2CompletedTreatmentMultiple Myeloma in Relapse1
1, 2CompletedTreatmentNeoplasm Metastases1
1, 2CompletedTreatmentNon-Infectious Anterior Uveitis1
1, 2CompletedTreatmentPatients Having Undergone Unilateral Cataract Extraction and Implantation of a Monofocal1
1, 2CompletedTreatmentPlasma Cell Myeloma2
1, 2CompletedTreatmentPlasma Cell Myeloma / Recurrent Plasma Cell Myeloma / Refractory Plasma Cell Myeloma1
1, 2CompletedTreatmentProstate Neoplasms1
1, 2CompletedTreatmentProstatic Neoplasms1
1, 2CompletedTreatmentRefractory Multiple Myeloma1
1, 2CompletedTreatmentRelapsed Or Refractory Multiple Myeloma1
1, 2CompletedTreatmentT-cell Acute Lymphoblastic Leukemia / T-cell Lymphoblastic Lymphoma1
1, 2Not Yet RecruitingTreatmentAmyloidosis1
1, 2Not Yet RecruitingTreatmentImmunotherapy / Lung Cancer Non-Small Cell Cancer (NSCLC)1
1, 2Not Yet RecruitingTreatmentMultiple Myeloma (MM)2
1, 2Not Yet RecruitingTreatmentMultiple Myeloma (MM) / Multiple Myeloma in Relapse1
1, 2Not Yet RecruitingTreatmentMultiple Myeloma (MM) / Relapsed Refractory Multiple Myeloma1
1, 2RecruitingOtherMultiple Myeloma (MM) / Relapsed/Refractory1
1, 2RecruitingTreatmentAL Amyloidosis1
1, 2RecruitingTreatmentAcute Lymphoblastic Leukaemia Recurrent / Acute Lymphoblastic Leukaemias (ALL) / Acute Lymphoblastic Leukemia, Adult / Acute Lymphoblastic Leukemia, in Relapse / Acute Lymphoblastic Leukemia, Pediatric1
1, 2RecruitingTreatmentAcute Lymphoblastic Leukaemia Recurrent / Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Leukemias / Philadelphia Chromosome Positive / Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Refractory Acute Lymphoblastic Leukemia / Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive / T(9;22)1
1, 2RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL)1
1, 2RecruitingTreatmentAmyloidosis / Plasma Cell Myeloma1
1, 2RecruitingTreatmentChronic Migraine Without Aura, Intractable / Migraine Disorders / Migraine With Typical Aura1
1, 2RecruitingTreatmentLoss of Chromosome 17p / Recurrent Plasma Cell Myeloma1
1, 2RecruitingTreatmentLymphohistiocytosis, Hemophagocytic1
1, 2RecruitingTreatmentMigraine1
1, 2RecruitingTreatmentMultiple Myeloma (MM)8
1, 2RecruitingTreatmentMultiple Myeloma (MM) / Refractory Multiple Myeloma / Relapsed/Refractory Multiple Myeloma1
1, 2RecruitingTreatmentMultiple Myeloma in Relapse1
1, 2RecruitingTreatmentPlasma Cell Myeloma1
1, 2RecruitingTreatmentRecurrent B Acute Lymphoblastic Leukemia / Recurrent T Acute Lymphoblastic Leukemia / Refractory B Acute Lymphoblastic Leukemia / Refractory T Acute Lymphoblastic Leukemia1
1, 2RecruitingTreatmentRefractory Non-Hodgkin's lymphoma / Relapsed Non Hodgkin Lymphoma1
1, 2RecruitingTreatmentRelapsed Refractory Multiple Myeloma1
1, 2RecruitingTreatmentRelapsed and/or Refractory Multiple Myeloma1
1, 2RecruitingTreatmentTreatments1
1, 2SuspendedTreatmentRecurrent Plasma Cell Myeloma1
1, 2SuspendedTreatmentRecurrent Plasma Cell Myeloma / Refractory Plasma Cell Myeloma2
1, 2SuspendedTreatmentRecurrent Plasma Cell Myeloma / T(11;14)1
1, 2TerminatedBasic ScienceDexamethasone Effect on miRNA Profile in Healthy Humans1
1, 2TerminatedTreatmentAcute Lymphoblastic Leukaemias (ALL) / Precursor B-Cell Lymphoblastic Leukemia / Precursor T-Cell Lymphoblastic Leukemia1
1, 2TerminatedTreatmentAggressive Marginal Zone Lymphoma (MZL) / Burkitt Lymphoma (BL) / Follicular Lymphoma Grade III (FL III°) / Lymphoma, Large B-Cell, Diffuse (DLBCL) / Mantle Cell Lymphoma (MCL), Blastoid Variant1
1, 2TerminatedTreatmentMacular Edema (ME)1
1, 2TerminatedTreatmentMalignant Lymphomas1
1, 2TerminatedTreatmentMultiple Myeloma (MM)5
1, 2TerminatedTreatmentMultiple Myeloma (MM) / Plasma Cell Neoplasms1
1, 2TerminatedTreatmentPlasma Cell Myeloma / Plasmacytosis / Recurrent Plasma Cell Myeloma / Smoldering Plasma Cell Myeloma1
1, 2TerminatedTreatmentRefractory Multiple Myeloma / Stage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
1, 2Unknown StatusPreventionTonsillectomy1
1, 2Unknown StatusTreatmentAmyloidosis1
1, 2Unknown StatusTreatmentMantle Cell Lymphoma (MCL)1
1, 2Unknown StatusTreatmentMultiple Myeloma (MM)4
1, 2Unknown StatusTreatmentRheumatic Diseases1
1, 2Unknown StatusTreatmentSwallowing1
1, 2WithdrawnTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL)1
1, 2WithdrawnTreatmentMelanoma1
1, 2WithdrawnTreatmentMultiple Myeloma (MM)3
1, 2WithdrawnTreatmentRecurrent Plasma Cell Myeloma / Refractory Plasma Cell Myeloma / T(11;14) Negative1
2Active Not RecruitingSupportive CareAdvanced Cancers / Advanced Malignant Neoplasm / Metastatic Malignant Neoplasm / Recurrent Malignant Neoplasm / Refractory Malignant Neoplasm / Tiredness1
2Active Not RecruitingSupportive CareMultiple Myeloma (MM)1
2Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemia Recurrent / Acute Lymphoblastic Leukaemias (ALL) / BCR-ABL1 Fusion Protein Expression / Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Leukemias / Philadelphia Chromosome Positive / T(9;22)1
2Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL)2
2Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Adult Acute Lymphoblastic Leukemia in Complete Remission / Burkitt's Lymphoma / CD20 Positive / Childhood Acute Lymphoblastic Leukemia in Complete Remission / Leukemias / Lymphoma, Lymphoblastic1
2Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Adult Acute Lymphoblastic Leukemia in Remission / Adult B Acute Lymphoblastic Leukemia / Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 / Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 / Adult L1 Acute Lymphoblastic Leukemia / Adult L2 Acute Lymphoblastic Leukemia / Adult T Acute Lymphoblastic Leukemia / Recurrent Adult Acute Lymphoblastic Leukemia / Untreated Adult Acute Lymphoblastic Leukemia1
2Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 / Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 / Untreated Adult Acute Lymphoblastic Leukemia1
2Active Not RecruitingTreatmentAcute Lymphoblastic Leukemia in Remission / Acute Lymphocytic Leukemia (ALL) / B Acute Lymphoblastic Leukemia / B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative1
2Active Not RecruitingTreatmentAcute,Leukemia, Lymphoid1
2Active Not RecruitingTreatmentAdvanced Cancers / Haematological disorders / Tumors, Solid1
2Active Not RecruitingTreatmentAdvanced Stage Diffuse Large B-Cell Non-Hodgkin's Lymphoma / Non-Hodgkin's Lymphoma (NHL)1
2Active Not RecruitingTreatmentAmyloidosis1
2Active Not RecruitingTreatmentBlastoid Variant Mantle Cell Lymphoma / CD20 Positive / Malignant Lymphomas / Mantle Cell Lymphoma (MCL) / Pleomorphic Variant Mantle Cell Lymphoma1
2Active Not RecruitingTreatmentCholangiocellular Carcinoma / Cholangiolar Carcinoma / Intrahepatic Cholangiocarcinoma / Peripheral Cholangiocarcinoma1
2Active Not RecruitingTreatmentChronic Kidney Disease (CKD) / Multiple Myeloma (MM)1
2Active Not RecruitingTreatmentColorectal Cancers / Metastatic Cancers1
2Active Not RecruitingTreatmentExtramedullary Plasmacytoma / Isolated Plasmacytoma of Bone / Light Chain Deposition Disease / Primary Systemic Amyloidosis / Stage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
2Active Not RecruitingTreatmentExtranodal NK/T-cell Lymphoma, Nasal Type1
2Active Not RecruitingTreatmentFirst Relapse / Multiple Myeloma (MM)1
2Active Not RecruitingTreatmentFollicular Lymphoma (FL) / Lymphoma of Mucosa-Associated Lymphoid Tissue / MALT Lymphoma / Mantle Cell Lymphoma (MCL) / Marginal Zone B-Cell Lymphoma / Small Lymphocytic Lymphoma (SLL) / Waldenström's Macroglobulinemia (WM)1
2Active Not RecruitingTreatmentHodgkins Disease (HD)1
2Active Not RecruitingTreatmentHormone Receptor Positive Breast Cancer1
2Active Not RecruitingTreatmentLabour1
2Active Not RecruitingTreatmentLeukemias2
2Active Not RecruitingTreatmentLight Chain Deposition Disease / Primary Systemic Amyloidosis1
2Active Not RecruitingTreatmentLiver Cancer1
2Active Not RecruitingTreatmentLung Cancers / Neoplasms Metastasis1
2Active Not RecruitingTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL)1
2Active Not RecruitingTreatmentLymphoma, Lymphoblastic1
2Active Not RecruitingTreatmentMalignant Lymphomas3
2Active Not RecruitingTreatmentMantle Cell Lymphoma (MCL)1
2Active Not RecruitingTreatmentMetastatic Brain Tumors / Metastatic Breast Cancer (MBC)1
2Active Not RecruitingTreatmentMultiple Myeloma (MM)40
2Active Not RecruitingTreatmentMultiple Myeloma (MM) / Relapse After Use of Lenalidomide and Bortezomib1
2Active Not RecruitingTreatmentMultiple Myeloma and Plasma Cell Neoplasm / Neurologic toxicity1
2Active Not RecruitingTreatmentNeoplasms Metastasis1
2Active Not RecruitingTreatmentNewly Diagnosed Multiple Myeloma1
2Active Not RecruitingTreatmentNon-Hodgkin's Lymphoma (NHL)1
2Active Not RecruitingTreatmentPlasma Cell Myeloma2
2Active Not RecruitingTreatmentPrior Bortezomib Therapy Acceptable / Waldenstroms1
2Active Not RecruitingTreatmentProstate Cancer1
2Active Not RecruitingTreatmentRecurrent B-Cell Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood B-Lymphoblastic Lymphoma1
2Active Not RecruitingTreatmentRecurrent Plasma Cell Myeloma / Refractory Plasma Cell Myeloma1
2Active Not RecruitingTreatmentRefractory Multiple Myeloma / Stage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
2Active Not RecruitingTreatmentRelapsed and/or Refractory Multiple Myeloma1
2Active Not RecruitingTreatmentSmoldering Multiple Myeloma (SMM) / Smoldering Multiple Myeloma at High Risk of Progression to Symptomatic Multiple Myeloma1
2Active Not RecruitingTreatmentSmoldering Multiple Myeloma (SMM) / Smoldering Myeloma1
2Active Not RecruitingTreatmentStage I Mantle Cell Lymphoma / Stage II Contiguous Mantle Cell Lymphoma / Stage II Non-Contiguous Mantle Cell Lymphoma / Stage III Mantle Cell Lymphoma / Stage IV Mantle Cell Lymphoma1
2Active Not RecruitingTreatmentStage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
2Active Not RecruitingTreatmentSteroids In Management Of Acute Asthma Exacerbations1
2Active Not RecruitingTreatmentTumors, Solid1
2Active Not RecruitingTreatmentWaldenström's Macroglobulinemia (WM)1
2CompletedNot AvailableDiabetic Macular Edema (DME)1
2CompletedOtherCataracts1
2CompletedPreventionAdvanced Breast Cancer1
2CompletedPreventionCINV1
2CompletedPreventionChemotherapy-Induced Nausea and Vomiting (CINV)2
2CompletedPreventionCongenital Hereditary Stromal Dystrophy of the Cornea / Fuchs' Endothelial Dystrophy / Keratoconus1
2CompletedPreventionDiabetes Mellitus (DM) / Macular Edema (ME) / Pseudophakia1
2CompletedPreventionEffects of; Anesthesia, in Labor and Delivery1
2CompletedPreventionInfants, Premature1
2CompletedPreventionMalignancies1
2CompletedPreventionNausea and Vomiting, Postoperative1
2CompletedPreventionPostspinal Shivering1
2CompletedPreventionSuspected Appendicitis1
2CompletedSupportive CareColorectal Cancers / Nausea and vomiting1
2CompletedSupportive CareDrug/Agent Toxicity by Tissue/Organ / Malignant Lymphomas1
2CompletedSupportive CareMalignant Lymphomas / Myeloma, Plasma-Cell1
2CompletedSupportive CareNausea / Vomiting1
2CompletedSupportive CarePain NOS1
2CompletedSupportive CarePost-Operative Nausea and Vomiting (PONV) / Postoperative pain1
2CompletedTreatment(Tennis Elbow) / Lateral Epicondylitis1
2CompletedTreatmentACTH / Cortisol Resistance / Glucocorticoid therapy / Mineralcorticoid / Negative Feedback1
2CompletedTreatmentAL Amyloidosis1
2CompletedTreatmentAcute Anterior Uveitis1
2CompletedTreatmentAcute Gouty Arthritis1
2CompletedTreatmentAcute Lymphoblastic Leukaemias (ALL)3
2CompletedTreatmentAcute Lymphoblastic Leukaemias (ALL) / Leukemias1
2CompletedTreatmentAcute Lymphoblastic Leukaemias (ALL) / Lymphoma, Lymphoblastic1
2CompletedTreatmentAcute Lymphocytic Leukemia (ALL)1
2CompletedTreatmentAdenocarcinoma of the Colon / Adenocarcinoma of the Rectum / Hepatic Metastases / Metastatic Colon Cancer / Recurrent Colon Cancer / Recurrent Rectal Cancer / Stage IV Rectal Cancer1
2CompletedTreatmentAdrenal Hyperplasia, Congenital1
2CompletedTreatmentAdult Nasal Type Extranodal NK/T-Cell Lymphoma / Anaplastic Large Cell Lymphoma / Angioimmunoblastic T-Cell Lymphoma / Cutaneous B-Cell Non-Hodgkin Lymphoma / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Hepatosplenic T-Cell Lymphoma / Intraocular Lymphoma / Nodal marginal zone B-cell lymphomas / Noncutaneous Extranodal Lymphoma / Peripheral T-Cell Lymphoma (PTCL) / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Grade III Lymphomatoid Granulomatosis / Recurrent Adult Hodgkin's Lymphoma / Recurrent Adult Immunoblastic Large Cell Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Adult T-Cell Leukemia/Lymphoma / Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Mycosis Fungoides/Sezary Syndrome / Recurrent Small Lymphocytic Lymphoma / Small Intestine Lymphoma / Splenic Marginal Zone Lymphoma / Testicular Lymphoma / Waldenström's Macroglobulinemia (WM)1
2CompletedTreatmentAdult Nasal Type Extranodal NK/T-Cell Lymphoma / Anaplastic Large Cell Lymphoma / Angioimmunoblastic T-Cell Lymphoma / Cutaneous B-Cell Non-Hodgkin Lymphoma / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Intraocular Lymphoma / Nodal marginal zone B-cell lymphomas / Peripheral T-Cell Lymphoma (PTCL) / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Grade III Lymphomatoid Granulomatosis / Recurrent Adult Hodgkin's Lymphoma / Recurrent Adult Immunoblastic Large Cell Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Adult T-Cell Leukemia/Lymphoma / Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Mycosis Fungoides/Sezary Syndrome / Recurrent Small Lymphocytic Lymphoma / Refractory Multiple Myeloma / Small Intestine Lymphoma / Splenic Marginal Zone Lymphoma / Waldenström's Macroglobulinemia (WM)1
2CompletedTreatmentAdult T-cell lymphomas/leukaemias1
2CompletedTreatmentAdvanced Multiple Myeloma1
2CompletedTreatmentAdvanced Solid Tumors1
2CompletedTreatmentAge Related Macular Degeneration (ARMD)1
2CompletedTreatmentAge-Related Macular Degeneration (ARMD) / Subfoveal Choroidal Neovascularization1
2CompletedTreatmentAmyloidosis2
2CompletedTreatmentAnterior Uveitis (AU)1
2CompletedTreatmentAnterior chamber inflammation / Cataracts / Postoperative pain1
2CompletedTreatmentB-cell Adult Acute Lymphoblastic Leukemia / B-cell Adult Acute Lymphoblastic Leukemia (ALL) / Ph Positive Adult Acute Lymphoblastic Leukemia / Ph-positive Adult Acute Lymphoblastic Leukemia (ALL) / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Lymphoblastic Leukemia (ALL) / T-cell Adult Acute Lymphoblastic Leukemia / T-cell Adult Acute Lymphoblastic Leukemia (ALL)1
2CompletedTreatmentBlast Crisis / Chronic Myeloid Leukemia (CML) / Leukemia, Lymphocytic, Acute / Philadelphia Chromosome1
2CompletedTreatmentBurkitt's Lymphoma / Burkitt'S-like Lymphoma1
2CompletedTreatmentCancer of the Ovary1
2CompletedTreatmentCancer of the Ovary / Chemotherapy-Induced Nausea and Vomiting (CINV)1
2CompletedTreatmentCancer, Breast2
2CompletedTreatmentCancer, Breast / Metastatic Breast Cancer (MBC)1
2CompletedTreatmentCataracts1
2CompletedTreatmentChemotherapy-Induced Nausea and Vomiting (CINV)2
2CompletedTreatmentChemotherapy-Induced / Nausea and vomiting1
2CompletedTreatmentChronic Allergic Conjunctivitis / Conjunctivitis, Seasonal Allergic1
2CompletedTreatmentChronic Lymphocytic Leukaemia (CLL)3
2CompletedTreatmentChronic Lymphocytic Leukaemia (CLL) / Leukemias2
2CompletedTreatmentChronic Lymphocytic Leukemia (CLL) - Refractory / Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue / Nodal Marginal Zone Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Small Lymphocytic Lymphoma / Splenic Marginal Zone Lymphoma / Waldenström's Macroglobulinemia (WM)1
2CompletedTreatmentChronic Myeloproliferative Disorders / Leukemias / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases1
2CompletedTreatmentColorectal Cancers / Metastatic Cancers1
2CompletedTreatmentConjunctivitis, Seasonal Allergic2
2CompletedTreatmentContiguous Stage II Grade 1 Follicular Lymphoma / Contiguous Stage II Grade 2 Follicular Lymphoma / Contiguous Stage II Marginal Zone Lymphoma / Cutaneous B-Cell Non-Hodgkin Lymphoma / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Nodal marginal zone B-cell lymphomas / Noncontiguous Stage II Grade 1 Follicular Lymphoma / Noncontiguous Stage II Grade 2 Follicular Lymphoma / Noncontiguous Stage II Marginal Zone Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Marginal Zone Lymphoma / Splenic Marginal Zone Lymphoma / Stage I Grade 1 Follicular Lymphoma / Stage I Grade 2 Follicular Lymphoma / Stage I Marginal Zone Lymphoma / Stage III Grade 1 Follicular Lymphoma / Stage III Grade 2 Follicular Lymphoma / Stage III Marginal Zone Lymphoma / Stage IV Grade 1 Follicular Lymphoma / Stage IV Grade 2 Follicular Lymphoma / Stage IV Marginal Zone Lymphoma / Waldenström's Macroglobulinemia (WM)1
2CompletedTreatmentContiguous Stage II Mantle Cell Lymphoma / Noncontiguous Stage II Mantle Cell Lymphoma / Stage I Mantle Cell Lymphoma / Stage III Mantle Cell Lymphoma / Stage IV Mantle Cell Lymphoma1
2CompletedTreatmentDS Stage I Plasma Cell Myeloma / DS Stage II Plasma Cell Myeloma / DS Stage III Plasma Cell Myeloma / Refractory Plasma Cell Myeloma1
2CompletedTreatmentDiabetes Mellitus (DM) / Diabetic Macular Edema (DME) / Retinopathy, Diabetic1
2CompletedTreatmentDiabetic Macular Edema (DME)2
2CompletedTreatmentDiabetic Macular Edema (DME) / Pseudophakic Cystoid Macular Edema1
2CompletedTreatmentDiabetic Macular Edema (DME) / Vitrectomy therapy1
2CompletedTreatmentDisease, Adnexal / Endocrine Gland Neoplasms / Genital Diseases, Female / Neoplasms / Neoplasms by Site / Neoplasms, Ovarian / Ovarian Diseases1
2CompletedTreatmentDry Eye Syndrome (DES)1
2CompletedTreatmentEar Diseases / Otitis / Otitis Externa / Otorhinolaryngologic Diseases1
2CompletedTreatmentEfficacy / Lung Cancer Non-Small Cell Cancer (NSCLC)1
2CompletedTreatmentEmpyema / Parapneumonic Pleural Effusion1
2CompletedTreatmentEndometrial Cancers1
2CompletedTreatmentEye Dryness1
2CompletedTreatmentFocus of Study / Thrombocytopenias1
2CompletedTreatmentGenetic Syndrome / Nervous System Disorders1
2CompletedTreatmentGenital Neoplasms, Female Urogenital Neoplasms / Neoplasms, Endometrial / Uterine Neoplasms1
2CompletedTreatmentGlomerulonephritis / Glomerulonephritis minimal lesion1
2CompletedTreatmentHealthy Volunteers1
2CompletedTreatmentHeavy Menstrual Bleeding1
2CompletedTreatmentHematologic Cancers1
2CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Meningitis, Cryptococcal1
2CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Non-Hodgkin's Lymphoma (NHL)1
2CompletedTreatmentImmune Thrombocytopenia1
2CompletedTreatmentImmune Thrombocytopenic Purpura ( ITP )2
2CompletedTreatmentLeiomyosarcomas / Liposarcoma1
2CompletedTreatmentLeukemia, Lymphocytic, Acute1
2CompletedTreatmentLeukemia, Lymphocytic / Precursor B-Cell Lymphoblastic Leukemia-Lymphoma1
2CompletedTreatmentLeukemias10
2CompletedTreatmentLeukemias / Malignant Lymphomas4
2CompletedTreatmentLeukemias / Neutropenias / Thrombocytopenias1
2CompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)2
2CompletedTreatmentLymphohistiocytosis, Hemophagocytic1
2CompletedTreatmentLymphoma, Hodgkins1
2CompletedTreatmentLymphoma, Hodgkins / Multiple Myeloma (MM) / Non-Hodgkin's Lymphoma (NHL)1
2CompletedTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL) / Poor prognosis1
2CompletedTreatmentMacular Degeneration / Subfoveal Choroidal Neovascularization1
2CompletedTreatmentMacular Edema (ME)1
2CompletedTreatmentMacular Edema (ME) / Retinopathy, Diabetic1
2CompletedTreatmentMacular Edema After Cataract Surgery in Patients With Diabetes Mellitus1
2CompletedTreatmentMaculopathies, Age-Related / Subfoveal Choroidal Neovascularization2
2CompletedTreatmentMalignant Lymphomas19
2CompletedTreatmentMalignant Neoplasm of Pancreas1
2CompletedTreatmentMantle Cell Lymphoma (MCL)2
2CompletedTreatmentMelanoma1
2CompletedTreatmentMenière's Disease2
2CompletedTreatmentMetastatic Castration Resistant Prostate Cancer1
2CompletedTreatmentMultiple Myeloma (MM)54
2CompletedTreatmentMultiple Myeloma (MM) / Plasma Cell Myeloma1
2CompletedTreatmentMultiple Myeloma (MM) / Refractory Multiple Myeloma / Relapsed Multiple Myeloma1
2CompletedTreatmentMultiple Myeloma (MM) / Renal Failure1
2CompletedTreatmentMultiple Myeloma (MM) / Renal Insuficiency1
2CompletedTreatmentMultiple Myeloma and Plasma Cell Neoplasm18
2CompletedTreatmentMultiple Myeloma in Relapse / Refractory Multiple Myeloma1
2CompletedTreatmentMultiple Myeloma in Relapse / Refractory Multiple Myeloma / Relapsed and Bortezomib Refractory Multiple Myeloma1
2CompletedTreatmentMyelodysplastic Syndromes1
2CompletedTreatmentMyxoid Liposarcoma1
2CompletedTreatmentNasal Type Extranodal NK/T-Cell Lymphoma1
2CompletedTreatmentNasopharyngeal Carcinoma1
2CompletedTreatmentNausea and Vomiting, Postoperative / Quality of Recovery / Same Day Surgery / Vaginal Prolapse1
2CompletedTreatmentNeoplasms, Breast1
2CompletedTreatmentNon-Hodgkin's Lymphoma (NHL)4
2CompletedTreatmentOcular Inflammation and Pain1
2CompletedTreatmentOral Chronic Graft-Versus-Host Disease1
2CompletedTreatmentOral Lichen Planus1
2CompletedTreatmentPOEMS Syndrome3
2CompletedTreatmentPancreatic Cancer Metastatic1
2CompletedTreatmentPemphigus1
2CompletedTreatmentPlasma Cell Myeloma3
2CompletedTreatmentPost-Operative Nausea and Vomiting (PONV)1
2CompletedTreatmentPrimary Amyloidosis of Light Chain Type1
2CompletedTreatmentPrimary Plasma Cell Leukemia1
2CompletedTreatmentPrimary Systemic Amyloidosis2
2CompletedTreatmentProstate Cancer5
2CompletedTreatmentRecurrent Non-Small Cell Lung Carcinoma / Stage IB Non-Small Cell Lung Carcinoma / Stage IIA Non-Small Cell Lung Carcinoma / Stage IIB Non-Small Cell Lung Carcinoma / Stage IIIA Non-Small Cell Lung Cancer / Stage IV Non-Small Cell Lung Cancer1
2CompletedTreatmentRecurrent Plasma Cell Myeloma / Refractory Plasma Cell Myeloma1
2CompletedTreatmentRelapse/Refractory Multiple Myeloma1
2CompletedTreatmentRelapsed Or Refractory Multiple Myeloma2
2CompletedTreatmentRelapsed and/or Refractory Multiple Myeloma1
2CompletedTreatmentSpinal Cord Compression From Neoplasm Metastasis1
2CompletedTreatmentSquamous Cell Carcinoma of the Head and Neck (SCCHN)1
2CompletedTreatmentStage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma2
2CompletedTreatmentStage IIIb Non-small Cell Lung Cancer / Stage IV Non-Small Cell Lung Cancer1
2CompletedTreatmentT-Cell Lymphomas1
2CompletedTreatmentTransitional Cell Carcinoma1
2CompletedTreatmentWaldenström's Macroglobulinemia (WM)3
2CompletedTreatmentWet Macular Degeneration1
2CompletedTreatmentHearing loss or impairment1
2Enrolling by InvitationTreatmentMultiple Myeloma (MM) / Smoldering Multiple Myeloma (SMM)1
2Not Yet RecruitingPreventionCancer, Breast / Lung Cancers / Melanoma / Metastatic Brain Tumors1
2Not Yet RecruitingPreventionCataracts / Ocular inflammatory conditions1
2Not Yet RecruitingSupportive CareCaudal Block1
2Not Yet RecruitingSupportive CareChemotherapy-Induced Nausea and Vomiting (CINV) / Lung Cancers1
2Not Yet RecruitingTreatmentBronchiolitis1
2Not Yet RecruitingTreatmentChronic Subdural Hematomas1
2Not Yet RecruitingTreatmentDexamethasone / Inflammatory Bowel Diseases (IBD) / Postoperative Complications / Postoperative paralytic ileus1
2Not Yet RecruitingTreatmentDiabetic Macular Edema (DME)1
2Not Yet RecruitingTreatmentGenetic Condition / Multiple Myeloma (MM) / Relapsed and Refractory Multiple Myeloma1
2Not Yet RecruitingTreatmentHigh Risk / Newly Diagnosed / Plasma Cell Myeloma1
2Not Yet RecruitingTreatmentMantle Cell Lymphoma (MCL)1
2Not Yet RecruitingTreatmentMultiple Myeloma (MM)5
2Not Yet RecruitingTreatmentMultiple Myeloma (MM) / Plasma Cell Myeloma1
2Not Yet RecruitingTreatmentNasopharyngeal Neoplasms / Vesicular Stomatitis1
2Not Yet RecruitingTreatmentNewly Diagnosed Multiple Myeloma1
2Not Yet RecruitingTreatmentOvarian Hyperstimulation Syndrome1
2Not Yet RecruitingTreatmentPeripheral Arterial Disease (PAD)1
2Not Yet RecruitingTreatmentVesicular Stomatitis1
2RecruitingPreventionChemotherapy Induced Neutropenia / Colo-rectal Cancer1
2RecruitingPreventionGraft Versus Host Disease (GVHD)1
2RecruitingPreventionMultiple Myeloma (MM)1
2RecruitingPreventionPostoperative pain1
2RecruitingScreeningRefractory Multiple Myeloma1
2RecruitingSupportive CareMultiple Myeloma (MM)1
2RecruitingSupportive CareSarcomas1
2RecruitingTreatmentAL Amyloidosis1
2RecruitingTreatmentALL (Acute Lymphoblastic Leukemia) / B-cell Acute Lymphoblastic Leukemia / Leukemias1
2RecruitingTreatmentAccelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Acute Lymphoblastic Leukaemias (ALL) / Adult Acute Lymphoblastic Leukemia in Complete Remission / B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 / Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Leukemias / Philadelphia Chromosome Positive / Untreated Adult Acute Lymphoblastic Leukemia1
2RecruitingTreatmentAcute Leukemias of Ambiguous Lineage / B Acute Lymphoblastic Leukemia / Childhood B Acute Lymphoblastic Leukemia / KMT2A Gene Rearrangement / Mixed Phenotype Acute Leukemia (MPAL)1
2RecruitingTreatmentAcute Lymphoblastic Leukaemia Recurrent / Acute Lymphoblastic Leukaemias (ALL) / Burkitt Leukemia/Lymphoma / Burkitt's Lymphoma / Hematopoietic/Lymphoid Cancer / High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements / Lymphoblastic lymphoma (Precursor T-lymphoblastic lymphoma/leukemia) refractory / Lymphoma, Lymphoblastic / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Burkitt Leukemia / Recurrent Burkitt Lymphoma / Recurrent Childhood Lymphoblastic Lymphoma / Recurrent High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements / Refractory Acute Lymphoblastic Leukemia / Refractory Burkitt Leukemia / Refractory Burkitt Lymphoma / Refractory High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements1
2RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / B Acute Lymphoblastic Leukemia / B Lymphoblastic Lymphoma / Leukemias1
2RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Leukemia Acute Myeloid Leukemia (AML)1
2RecruitingTreatmentApophysitis; Juvenile1
2RecruitingTreatmentB Acute Lymphoblastic Leukemia / CRLF2 Positive / Leukemias / Recurrent Ph-Like Acute Lymphoblastic Leukemia / Refractory Ph-Like Acute Lymphoblastic Leukemia1
2RecruitingTreatmentCD20 Positive / Mantle Cell Lymphoma (MCL)1
2RecruitingTreatmentCancer - Multiple Myeloma / Multiple Myeloma (MM)1
2RecruitingTreatmentCardiac Amyloidosis1
2RecruitingTreatmentCervicgenic Upper Extremity Radiculopathy1
2RecruitingTreatmentChemotherapy-Induced Nausea and Vomiting (CINV)1
2RecruitingTreatmentChemotherapy-Induced Nausea and Vomiting (CINV) / Head Neck Cancer / Vomiting1
2RecruitingTreatmentChemotherapy-Induced Nausea and Vomiting (CINV) / Nausea / Vomiting1
2RecruitingTreatmentChronic Limb Ischemia2
2RecruitingTreatmentChronic Lung Disease of Prematurity1
2RecruitingTreatmentDiffuse Large B-cells Non-Hodgkin Lymphoma1
2RecruitingTreatmentExtranodal NK-T-CELL LYMPHOMA / NK/T Cell Lymphoma1
2RecruitingTreatmentExtranodal NK/T-cell Lymphoma, Nasal Type1
2RecruitingTreatmentHIV-1-infection / Tuberculosis Meningitis1
2RecruitingTreatmentHNSCC / HPV-Related Squamous Cell Carcinoma1
2RecruitingTreatmentHematopoietic/Lymphoid Cancer / Richter's Transformation1
2RecruitingTreatmentHenoch-Schoenlein Purpura (HSP)1
2RecruitingTreatmentHigh Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements / Recurrent Diffuse Large B-Cell Lymphoma / Recurrent Hodgkin Lymphoma / Recurrent Lymphoma / Refractory Diffuse Large B Cell Lymphoma / Refractory Lymphomas1
2RecruitingTreatmentImmune Thrombocytopenia2
2RecruitingTreatmentImpaired Renal Function / RrMM1
2RecruitingTreatmentKnee Osteoarthritis (Knee OA)1
2RecruitingTreatmentLeukaemia, Lymphoblastic1
2RecruitingTreatmentLeukemia Acute Myeloid Leukemia (AML)1
2RecruitingTreatmentLeukemia, Plasma Cell / Plasma Cell Myeloma / Plasmacytoma1
2RecruitingTreatmentLeukemias2
2RecruitingTreatmentLichen Planus (LP)1
2RecruitingTreatmentLymphoma, Extranodal NK-T-Cell1
2RecruitingTreatmentLymphoma, Hodgkins1
2RecruitingTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL)3
2RecruitingTreatmentLymphoma, Lymphoblastic1
2RecruitingTreatmentLymphoplasmacytic Lymphoma / Waldenström's Macroglobulinemia (WM)1
2RecruitingTreatmentMacular Edema (ME)1
2RecruitingTreatmentMalignant Lymphomas2
2RecruitingTreatmentMalignant bowel obstruction1
2RecruitingTreatmentMantle Cell Lymphoma (MCL)1
2RecruitingTreatmentMultiple Myeloma (MM)30
2RecruitingTreatmentMultiple Myeloma (MM) / Plasma Cell Myeloma1
2RecruitingTreatmentMultiple Myeloma (MM) / Relapsed Hematologic Malignancy1
2RecruitingTreatmentMultiple Myeloma (MM) / Relapsed Or Refractory Multiple Myeloma1
2RecruitingTreatmentMultiple Myeloma (MM) / Relapsed/Refractory1
2RecruitingTreatmentMultiple Myeloma in Relapse / Multiple Myeloma Progression / Refractory Multiple Myeloma1
2RecruitingTreatmentMultiple Myeloma in Relapse3
2RecruitingTreatmentMultiple Myeloma in Relapse / Refractory Multiple Myeloma1
2RecruitingTreatmentMultiple Myeloma in Relapse / Relapse/Refractory Multiple Myeloma1
2RecruitingTreatmentMyeloma Multiple / Myeloma, Plasma-Cell / Myeloma-Multiple / Plasma Cell Myeloma1
2RecruitingTreatmentObstructive Sleep Apnea of Child / Tonsillitis1
2RecruitingTreatmentPlasmacytoma / POEMS Syndrome1
2RecruitingTreatmentPeripheral T-Cell Lymphoma (PTCL)1
2RecruitingTreatmentPlasma Cell Myeloma2
2RecruitingTreatmentPlasma Cell Myeloma / Residual Disease1
2RecruitingTreatmentPulmonary Fibrosis1
2RecruitingTreatmentRecurrent Plasma Cell Myeloma1
2RecruitingTreatmentRecurrent Plasma Cell Myeloma / Refractory Plasma Cell Myeloma6
2RecruitingTreatmentRecurrent Primary Amyloidosis1
2RecruitingTreatmentRefractory Multiple Myeloma2
2RecruitingTreatmentRefractory Plasma Cell Myeloma1
2RecruitingTreatmentRelapse and / or Refractory Myeloma1
2RecruitingTreatmentRelapsed Or Refractory Multiple Myeloma1
2RecruitingTreatmentRelapsed and/or Refractory Cutaneous T-cell Lymphoma1
2RecruitingTreatmentRelapsed and/or Refractory Multiple Myeloma2
2RecruitingTreatmentRelapsed/Refractory Multiple Myeloma1
2RecruitingTreatmentSmoldering Multiple Myeloma (SMM)2
2RecruitingTreatmentSmouldering Myeloma1
2RecruitingTreatmentSudden Sensorineural Hearing Loss (SSNHL)1
2RecruitingTreatmentWaldenström's Macroglobulinemia (WM)1
2SuspendedTreatmentAnaplastic Large Cell Lymphoma, ALK-Positive / Ann Arbor Stage II Childhood Anaplastic Large Cell Lymphoma / Ann Arbor Stage II Noncutaneous Childhood Anaplastic Large Cell Lymphoma / Ann Arbor Stage III Childhood Anaplastic Large Cell Lymphoma / Ann Arbor Stage III Noncutaneous Childhood Anaplastic Large Cell Lymphoma / Ann Arbor Stage IV Childhood Anaplastic Large Cell Lymphoma / Ann Arbor Stage IV Noncutaneous Childhood Anaplastic Large Cell Lymphoma / CD30-Positive Neoplastic Cells Present / Stage II Childhood Anaplastic Large Cell Lymphoma / Stage III Childhood Anaplastic Large Cell Lymphoma / Stage IV Childhood Anaplastic Large Cell Lymphoma1
2SuspendedTreatmentMalignant Lymphomas1
2SuspendedTreatmentMultiple Myeloma (MM)1
2SuspendedTreatmentSmoldering Multiple Myeloma (SMM)1
2TerminatedPreventionCisplatin Induced Hearing Loss1
2TerminatedPreventionNausea / Vomiting1
2TerminatedSupportive CareBrain Cancer1
2TerminatedSupportive CareNausea and vomiting / Stage III Squamous Cell Carcinoma of the Hypopharynx / Stage III Squamous Cell Carcinoma of the Larynx / Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage III Squamous Cell Carcinoma of the Nasopharynx / Stage III Squamous Cell Carcinoma of the Oropharynx / Stage IV Squamous Cell Carcinoma of the Hypopharynx / Stage IV Squamous Cell Carcinoma of the Larynx / Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage IV Squamous Cell Carcinoma of the Nasopharynx / Stage IV Squamous Cell Carcinoma of the Oropharynx1
2TerminatedSupportive CareNausea / Unspecified Childhood Solid Tumor, Protocol Specific / Vomiting1
2TerminatedTreatmentAcute Adenoviral Conjunctivitis1
2TerminatedTreatmentAcute Lymphoblastic Leukaemias (ALL)1
2TerminatedTreatmentAcute Lymphoblastic Leukaemias (ALL) / Leukemia, B-Cell / Leukemia, T-Cell / Non-Hodgkin's Lymphoma (NHL)1
2TerminatedTreatmentAcute Lymphoblastic Leukaemias (ALL) / Lymphoma, Lymphoblastic1
2TerminatedTreatmentAcute Lymphocytic Leukemia (ALL) / Leukemia Acute Myeloid Leukemia (AML) / Mixed Lineage Acute Leukemia1
2TerminatedTreatmentAcute Otitis Media1
2TerminatedTreatmentBladder Cancers1
2TerminatedTreatmentCancer of the Breast / Cancer, Breast / Neoplasms, Breast1
2TerminatedTreatmentCancer, Breast1
2TerminatedTreatmentCancer, Breast / Lung Cancers1
2TerminatedTreatmentCorneal Infiltrates1
2TerminatedTreatmentCystoid Macular Edema / Macular Edema (ME) / Radiation Maculopathy / Radiation Retinopathy / Uveal Melanoma1
2TerminatedTreatmentFollicular Lymphoma (FL)1
2TerminatedTreatmentHead and Neck Carcinoma / Lung Cancer Non-Small Cell Cancer (NSCLC)1
2TerminatedTreatmentHodgkins Disease (HD)1
2TerminatedTreatmentLeukemias2
2TerminatedTreatmentLeukemias / Lymphoma, Lymphoblastic / Malignant Lymphomas / Precursor-B Acute Lymphoblastic Leukemia1
2TerminatedTreatmentLymphoma, B-Cell / Non-Hodgkin's Lymphoma (NHL)1
2TerminatedTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL)2
2TerminatedTreatmentMaculopathies, Age-Related / Subfoveal Choroidal Neovascularization1
2TerminatedTreatmentMalignancies / Non-Hodgkin's Lymphoma (NHL)1
2TerminatedTreatmentMalignant Neoplasm of Pancreas1
2TerminatedTreatmentMantle Cell Lymphoma (MCL)1
2TerminatedTreatmentMenière's Disease1
2TerminatedTreatmentMultiple Myeloma (MM)13
2TerminatedTreatmentMultiple Myeloma and Plasma Cell Neoplasm2
2TerminatedTreatmentPost-Operative Nausea and Vomiting (PONV) / Vomiting1
2TerminatedTreatmentProstate Cancer3
2TerminatedTreatmentRadiculopathy, Cervical1
2TerminatedTreatmentRecurrent Adult Acute Lymphoblastic Leukemia1
2TerminatedTreatmentRefractory Multiple Myeloma2
2TerminatedTreatmentRefractory Plasma Cell Myeloma1
2TerminatedTreatmentSj(SqrRoot)(Delta)Gren s Syndrome / Sjögren's Syndrome / Xerostomia1
2TerminatedTreatmentStage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
2TerminatedTreatmentSurgery, Hand1
2TerminatedTreatmentT-cell Type Acute Leukemia-Precursor T-lymphoblastic Lymphoma/Leukaemia1
2Unknown StatusPreventionAirway Obstruction2
2Unknown StatusPreventionPost-Operative Nausea and Vomiting (PONV) / Tumors, Solid1
2Unknown StatusPreventionProliferative Diabetic Retinopathy (PDR)1
2Unknown StatusSupportive CareNausea / Vomiting1
2Unknown StatusTreatmentAcute Lymphoblastic Leukaemias (ALL)1
2Unknown StatusTreatmentBortezomib / Cyclophosphamide / Dexamethasone / Granulocyte Colony-Stimulating Factor / Plasma Cell Myeloma1
2Unknown StatusTreatmentBrain and Central Nervous System Tumors / Extragonadal Germ Cell Tumor / Testicular germ cell tumour1
2Unknown StatusTreatmentCancer, Breast1
2Unknown StatusTreatmentDiabetic Macular Edema (DME) / NPDR - Non Proliferative Diabetic Retinopathy / Proliferative Diabetic Retinopathy (PDR)1
2Unknown StatusTreatmentLeukemia, Plasma Cell / Multiple Myeloma (MM)1
2Unknown StatusTreatmentLeukemias3
2Unknown StatusTreatmentLymphoid Blastic Phase of Chronic Myeloid Leukemia / Philadelphia Positive Acute Lymphoblastic Leukemia1
2Unknown StatusTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL)1
2Unknown StatusTreatmentMalignant Lymphomas1
2Unknown StatusTreatmentMalignant / Mesothelioma / Pleural1
2Unknown StatusTreatmentMantle Cell Lymphoma (MCL)1
2Unknown StatusTreatmentMultiple Myeloma (MM)4
2Unknown StatusTreatmentMultiple Myeloma Light Chain Induced Renal Insufficiency1
2Unknown StatusTreatmentMultiple Myeloma and Plasma Cell Neoplasm4
2Unknown StatusTreatmentPOEMS Syndrome1
2Unknown StatusTreatmentPost-Operative Nausea and Vomiting (PONV) / Postoperative pain / Postoperative Vocal Function / Thyroidectomy1
2Unknown StatusTreatmentRectal Carcinoma1
2Unknown StatusTreatmentRefractory Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
2Unknown StatusTreatmentUlcerative Colitis (UC)1
2Unknown StatusTreatmentWaldenström's Macroglobulinemia (WM)1
2WithdrawnPreventionMultiple Myeloma (MM)1
2WithdrawnTreatmentAge Related Macular Degeneration (ARMD)1
2WithdrawnTreatmentAmyloidosis / Immunoglobulin Light Chain Deposition1
2WithdrawnTreatmentB-cell Adult Acute Lymphoblastic Leukemia / Blastic Phase Chronic Myelogenous Leukemia / Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Philadelphia Chromosome Positive Adult Precursor Acute Lymphoblastic Leukemia / Untreated Adult Acute Lymphoblastic Leukemia1
2WithdrawnTreatmentCCND1 Positive / CD20-Positive Neoplastic Cells Present / Hematopoietic/Lymphoid Cancer / Mantle Cell Lymphoma (MCL)1
2WithdrawnTreatmentCancer, Breast1
2WithdrawnTreatmentColorectal Adenocarcinoma Metastatic to the Liver1
2WithdrawnTreatmentConjunctivitis, Seasonal Allergic1
2WithdrawnTreatmentGerm Cell Tumors1
2WithdrawnTreatmentImmune Thrombocytopenia1
2WithdrawnTreatmentMalignant Lymphomas4
2WithdrawnTreatmentMultiple Myeloma (MM)12
2WithdrawnTreatmentMultiple Myeloma (MM) / Multiple Myeloma in Relapse1
2WithdrawnTreatmentMultiple Myeloma (MM) / Plasma Cell Myeloma1
2WithdrawnTreatmentNeoplastic Plasma Cells 30 Percent or More of Bone Marrow Nucleated Cells / Recurrent Plasma Cell Myeloma1
2WithdrawnTreatmentPatients With Acute Pancreatitis1
2WithdrawnTreatmentPlasma Cell Myeloma1
2WithdrawnTreatmentRefractory Multiple Myeloma / Stage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
2WithdrawnTreatmentRefractory Plasma Cell Neoplasm / Stage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
2WithdrawnTreatmentRelapse/Refractory Multiple Myeloma2
2WithdrawnTreatmentRenal Cell Adenocarcinoma1
2WithdrawnTreatmentStage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
2, 3Active Not RecruitingTreatmentImmune Thrombocytopenia / Pregnancy1
2, 3CompletedOtherLocal Anesthesia1
2, 3CompletedPreventionAdjuvants, Anesthesia1
2, 3CompletedPreventionPost-Operative Nausea and Vomiting (PONV)1
2, 3CompletedTreatmentAdult B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 / Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
2, 3CompletedTreatmentCellophane Maculopathy / Epiretinal Membrane / Macular Edema (ME) / Retinal Edema1
2, 3CompletedTreatmentHeart Failure1
2, 3CompletedTreatmentMultiple Myeloma (MM)4
2, 3CompletedTreatmentNon-Ischemic Central Retinal Vein Occlusion1
2, 3CompletedTreatmentPemphigus1
2, 3CompletedTreatmentPlantar fascial fibromatosis1
2, 3CompletedTreatmentRetinal Vein Occlusions(RVO)1
2, 3CompletedTreatmentTuberculous Meningitis1
2, 3CompletedTreatmentDiffuse posterior uveitis / Uveitis, Intermediate1
2, 3Not Yet RecruitingPreventionDexamethasone / Hip Dysplasia / Post-Operative Nausea and Vomiting (PONV) / Postoperative pain1
2, 3Not Yet RecruitingTreatmentResected Liver Metastases From Colorectal Cancer1
2, 3Not Yet RecruitingTreatmentWaldenström's Macroglobulinemia (WM)1
2, 3RecruitingPreventionAnalgesia, Postoperative1
2, 3RecruitingSupportive CareAdvanced Malignant Neoplasm / Cancer Fatigue / Metastatic Malignant Neoplasm / Recurrent Malignant Neoplasm1
2, 3RecruitingSupportive CareAdverse Events / Cervical Cancers / Chemotherapy-Induced Nausea and Vomiting (CINV)1
2, 3RecruitingSupportive CareOsteoarthritis (OA) / Total Hip Arthroplasty (THA) / Total Knee Arthroplasty (TKA)1
2, 3RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Acute Lymphoblastic Lymphoma1
2, 3RecruitingTreatmentAcute Pharyngitis1
2, 3RecruitingTreatmentAdult Acute Lymphoblastic Leukemia / Adult Lymphoblastic Lymphoma / Leukaemia, Lymphoblastic / Leukemia, Acute / Leukemia, T Cell / Leukemias / Lymphoma, Lymphoblastic1
2, 3RecruitingTreatmentChronic Subdural Hematomas1
2, 3RecruitingTreatmentCroticosteroid Therapy / Idiopathic Thrombocytopenic Purpura (ITP)1
2, 3RecruitingTreatmentHepatectomy / Hyperbilirubinemia / Jaundice / Liver Dysfunction1
2, 3RecruitingTreatmentLeukaemia, Lymphoblastic / Leukemia, Acute / Leukemia, T Cell1
2, 3RecruitingTreatmentLeukemias2
2, 3RecruitingTreatmentPost Surgical Pain1
2, 3RecruitingTreatmentPremature Births1
2, 3RecruitingTreatmentRelapsed and/or Refractory Multiple Myeloma1
2, 3TerminatedPreventionShoulder Surgery1
2, 3TerminatedTreatmentAnterior Uveitis (AU)1
2, 3TerminatedTreatmentChronic Subdural Hematomas1
2, 3TerminatedTreatmentLeptospirosis1
2, 3TerminatedTreatmentNeurocysticercosis1
2, 3TerminatedTreatmentOral Cavity Cancer1
2, 3Unknown StatusTreatmentAdult Acute Lymphocytic Leukemia1
2, 3Unknown StatusTreatmentDiabetic Macular Edema (DME)1
2, 3Unknown StatusTreatmentLeukemias1
2, 3WithdrawnTreatmentHuman Immunodeficiency Virus Infection(HIV)/Acquired Immunodeficiency Syndrome (AIDS) / Immune Reconstitution Inflammatory Syndrome / Immune Reconstitution Syndrome / Tuberculosis Infection1
3Active Not RecruitingBasic ScienceNewly Diagnosed, Previously Untreated Multiple Myeloma1
3Active Not RecruitingPreventionChildhood Cancers / Nausea / Vomiting1
3Active Not RecruitingPreventionDysphasia1
3Active Not RecruitingPreventionSwallowing Disorders1
3Active Not RecruitingSupportive CareHematopoietic/Lymphoid Cancer / Nausea and vomiting / Unspecified Adult Solid Tumor, Protocol Specific1
3Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL)1
3Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Adult B Lymphoblastic Lymphoma / Ann Arbor Stage I B Lymphoblastic Lymphoma / Ann Arbor Stage II B Lymphoblastic Lymphoma / Childhood B Acute Lymphoblastic Leukemia / Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 / Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 / Childhood B Lymphoblastic Lymphoma / Down Syndrome (DS) / Hypodiploid B Acute Lymphoblastic Leukemia / Intrachromosomal Amplification of Chromosome 21 / Philadelphia Chromosome Positive / Stage I B Lymphoblastic Lymphoma / Stage II B Lymphoblastic Lymphoma / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
3Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Adult T Acute Lymphoblastic Leukemia / Ann Arbor Stage II Adult Lymphoblastic Lymphoma / Ann Arbor Stage II Childhood Lymphoblastic Lymphoma / Ann Arbor Stage III Adult Lymphoblastic Lymphoma / Ann Arbor Stage III Childhood Lymphoblastic Lymphoma / Ann Arbor Stage IV Adult Lymphoblastic Lymphoma / Ann Arbor Stage IV Childhood Lymphoblastic Lymphoma / Childhood T Acute Lymphoblastic Leukemia / Stage II Adult Lymphoblastic Lymphoma / Stage II Childhood Lymphoblastic Lymphoma / Stage II Contiguous Adult Lymphoblastic Lymphoma / Stage II Non-Contiguous Adult Lymphoblastic Lymphoma / Stage III Adult Lymphoblastic Lymphoma / Stage III Childhood Lymphoblastic Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Stage IV Childhood Lymphoblastic Lymphoma / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
3Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / B Acute Lymphoblastic Leukemia / Central Nervous System Leukemia / Cognitive Side Effects of Cancer Therapy / Neurotoxicity Syndrome / Osteonecrosis / Pain NOS / Ph-Like Acute Lymphoblastic Leukemia / Testicular Leukemia / Therapy-Related Toxicity / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
3Active Not RecruitingTreatmentAcute Promyelocytic Leukemia With PML-RARA / Adult Acute Promyelocytic Leukemia With t(15;17)(q22;q12); PML-RARA / Childhood Acute Promyelocytic Leukemia With t(15;17)(q22;q12); PML-RARA / Untreated Adult Acute Myeloid Leukemia / Untreated Childhood Myeloid Neoplasm1
3Active Not RecruitingTreatmentAmyloidosis1
3Active Not RecruitingTreatmentB Acute Lymphoblastic Leukemia / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Childhood Acute Lymphoblastic Leukemia1
3Active Not RecruitingTreatmentB-cell Childhood Acute Lymphoblastic Leukemia / Intermediate Risk Recurrent Childhood Acute Lymphoblastic Leukemia / L1 Childhood Acute Lymphoblastic Leukemia / L2 Childhood Acute Lymphoblastic Leukemia1
3Active Not RecruitingTreatmentB-cell Childhood Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
3Active Not RecruitingTreatmentBrachial Plexus Block / Postoperative pain1
3Active Not RecruitingTreatmentCancer, Breast1
3Active Not RecruitingTreatmentChildhood Favorable Prognosis Hodgkin Lymphoma / Childhood Lymphocyte Depletion Hodgkin Lymphoma / Childhood Mixed Cellularity Hodgkin Lymphoma / Childhood Nodular Sclerosis Hodgkin Lymphoma / Stage I Childhood Hodgkin Lymphoma / Stage II Childhood Hodgkin Lymphoma1
3Active Not RecruitingTreatmentDS Stage I Plasma Cell Myeloma / DS Stage II Plasma Cell Myeloma / DS Stage III Plasma Cell Myeloma1
3Active Not RecruitingTreatmentDS Stage I Plasma Cell Myeloma / DS Stage II Plasma Cell Myeloma / DS Stage III Plasma Cell Myeloma / Stage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
3Active Not RecruitingTreatmentDrug/Agent Toxicity by Tissue/Organ / Leukemias1
3Active Not RecruitingTreatmentGlaucoma1
3Active Not RecruitingTreatmentInflammation and Pain Associated With Cataract Surgery1
3Active Not RecruitingTreatmentLeukemias2
3Active Not RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)2
3Active Not RecruitingTreatmentLung Cancer Small Cell Lung Cancer (SCLC)1
3Active Not RecruitingTreatmentLymphoma (Myeloma) / Malignant Lymphomas / Multiple Myeloma (MM)1
3Active Not RecruitingTreatmentMacular Edema (ME)1
3Active Not RecruitingTreatmentMalignant Lymphomas1
3Active Not RecruitingTreatmentMantle Cell Lymphoma (MCL)1
3Active Not RecruitingTreatmentMultiple Myeloma (MM)23
3Active Not RecruitingTreatmentPlasma Cell Myeloma3
3Active Not RecruitingTreatmentPostoperative pain1
3Active Not RecruitingTreatmentProstate Cancer1
3Active Not RecruitingTreatmentRefractory Multiple Myeloma / Relapsed Multiple Myeloma1
3Active Not RecruitingTreatmentRelapsed Or Refractory Multiple Myeloma1
3Active Not RecruitingTreatmentRelapsed and Refractory Multiple Myeloma1
3Active Not RecruitingTreatmentRelapsed or Refractory Systemic Light Chain Amyloidosis1
3Active Not RecruitingTreatmentSolitary Osseous Plasmacytoma1
3Active Not RecruitingTreatmentWaldenström's Macroglobulinemia (WM)1
3CompletedNot AvailableAcute Otitis Media1
3CompletedNot AvailablePneumonia1
3CompletedDiagnosticDevelopment1
3CompletedDiagnosticPolycystic Ovarian Syndrome1
3CompletedPreventionAcute Urinary Tract Infection / Urinary Tract Infections (UTIs)1
3CompletedPreventionCataracts1
3CompletedPreventionCataracts / Cystoid Macular Edema / Diabetes Mellitus (DM)1
3CompletedPreventionChemotherapy-Induced Nausea and Vomiting (CINV)12
3CompletedPreventionChemotherapy-Induced Nausea and Vomiting (CINV) / Nausea / Vomiting1
3CompletedPreventionChronic Lung Diseases / Respiratory Distress Syndrome (RDS)1
3CompletedPreventionChronic Renal Failure (CRF)1
3CompletedPreventionDiabetic Macular Edema (DME)1
3CompletedPreventionHernia, Femoral / Inguinal Hernias1
3CompletedPreventionNeoplasms1
3CompletedPreventionPelvic Organ Prolapse (POP) / Ponv1
3CompletedPreventionPost-Operative Nausea and Vomiting (PONV)1
3CompletedPreventionPost-Operative Nausea and Vomiting (PONV) / Postoperative Fatigue / Postoperative pain1
3CompletedPreventionPost-Operative Nausea and Vomiting (PONV) / Postoperative pain1
3CompletedPreventionPostoperative Wound Infection / Surgery, Colon1
3CompletedPreventionPostoperative pain1
3CompletedPreventionThyroid Diseases / Thyroidectomy1
3CompletedPreventionVomiting1
3CompletedSupportive CareAnemias / Prostate Cancer / Tiredness1
3CompletedSupportive CareBrachial Plexus Block1
3CompletedSupportive CareChemotherapy-Induced Nausea and Vomiting (CINV)1
3CompletedSupportive CareChemotherapy-Induced Nausea and Vomiting (CINV) / Nausea and vomiting1
3CompletedSupportive CareChemotherapy-Induced Nausea and Vomiting (CINV) / Unspecified Adult Solid Tumor, Protocol Specific1
3CompletedSupportive CareGenital Neoplasms, Female / Nausea / Vomiting1
3CompletedSupportive CareMalignancies1
3CompletedSupportive CareNausea1
3CompletedSupportive CareNausea and vomiting / Unspecified Adult Solid Tumor, Protocol Specific3
3CompletedTreatmentAbdominal wall neoplasm / Fallopian Tube Neoplasms / Neoplasms, Ovarian1
3CompletedTreatmentAcute Lymphoblastic Leukaemias (ALL)4
3CompletedTreatmentAcute Lymphoblastic Leukaemias (ALL) / Acute Undifferentiated Leukemia (AUL) / Childhood T Acute Lymphoblastic Leukemia / T-cell Childhood Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
3CompletedTreatmentAcute Lymphoblastic Leukaemias (ALL) / Adult T Acute Lymphoblastic Leukemia / Ann Arbor Stage II Adult T-Cell Leukemia/Lymphoma / Ann Arbor Stage II Childhood Lymphoblastic Lymphoma / Ann Arbor Stage II Contiguous Adult Lymphoblastic Lymphoma / Ann Arbor Stage II Non-Contiguous Adult Lymphoblastic Lymphoma / Ann Arbor Stage III Adult Lymphoblastic Lymphoma / Ann Arbor Stage III Adult T-Cell Leukemia/Lymphoma / Ann Arbor Stage III Childhood Lymphoblastic Lymphoma / Ann Arbor Stage IV Adult Lymphoblastic Lymphoma / Ann Arbor Stage IV Adult T-Cell Leukemia/Lymphoma / Ann Arbor Stage IV Childhood Lymphoblastic Lymphoma / Childhood T Acute Lymphoblastic Leukemia / Stage II Adult T-Cell Leukemia/Lymphoma / Stage II Childhood Lymphoblastic Lymphoma / Stage II Contiguous Adult Lymphoblastic Lymphoma / Stage II Non-Contiguous Adult Lymphoblastic Lymphoma / Stage III Adult Lymphoblastic Lymphoma / Stage III Adult T-Cell Leukemia/Lymphoma / Stage III Childhood Lymphoblastic Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Stage IV Adult T-Cell Leukemia/Lymphoma / Stage IV Childhood Lymphoblastic Lymphoma / T Acute Lymphoblastic Leukemia / T Lymphoblastic Lymphoma / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
3CompletedTreatmentAcute Otitis Externa2
3CompletedTreatmentAmyloidosis1
3CompletedTreatmentAnaesthesia therapy / Forearm Injuries / Postoperative pain1
3CompletedTreatmentAnesthesia, Conduction1
3CompletedTreatmentAnterior Uveitis (AU)2
3CompletedTreatmentAsthma Bronchial2
3CompletedTreatmentBlepharoconjunctivitis1
3CompletedTreatmentBone Metastases1
3CompletedTreatmentBronchiolitis1
3CompletedTreatmentCancer of the Ovary1
3CompletedTreatmentCarcinoma NOS / Non Small Cell Lung1
3CompletedTreatmentCardiopulmonary Bypass / Defect, Congenital Heart / Surgery, Cardiac1
3CompletedTreatmentCataracts3
3CompletedTreatmentCataracts / Inflammatory Reaction1
3CompletedTreatmentCentral Retinal Vein Occlusion (CRVO) / Macular Edema (ME) / Visual Impairment1
3CompletedTreatmentChemotherapy-Induced Nausea and Vomiting (CINV)2
3CompletedTreatmentChemotherapy-Induced Nausea and Vomiting (CINV) / Nausea / Vomiting1
3CompletedTreatmentChildhood Acute Erythroleukemia (M6) / Childhood Acute Megakaryocytic Leukemia (M7) / Childhood Acute Monoblastic Leukemia (M5a) / Childhood Acute Monocytic Leukemia (M5b) / Childhood Acute Myeloblastic Leukemia With Maturation (M2) / Childhood Acute Myeloblastic Leukemia Without Maturation (M1) / Childhood Acute Myelomonocytic Leukemia (M4) / Childhood Myelodysplastic Syndromes / Chronic Myelomonocytic Leukemia / De Novo Myelodysplastic Syndromes / Refractory Anemia / Refractory Anemia With Excess Blasts / Refractory Anemia With Excess Blasts in Transformation / Refractory Anemia With Ringed Sideroblasts / Secondary Myelodysplastic Syndromes / Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies1
3CompletedTreatmentChildhood Acute Lymphoblastic Leukemia in Remission / Recurrent Childhood Acute Lymphoblastic Leukemia1
3CompletedTreatmentChildhood Lymphocyte-Depleted Classical Hodgkin Lymphoma / Childhood Mixed Cellularity Classical Hodgkin Lymphoma / Childhood Nodular Lymphocyte Predominant Hodgkin Lymphoma / Childhood Nodular Sclerosis Classical Hodgkin Lymphoma / Malignant Lymphomas / Stage I Childhood Hodgkin Lymphoma / Stage II Childhood Hodgkin Lymphoma / Stage III Childhood Hodgkin Lymphoma / Stage IV Childhood Hodgkin Lymphoma1
3CompletedTreatmentChronic Allergic Conjunctivitis1
3CompletedTreatmentChronic Lung Disease of Prematurity1
3CompletedTreatmentChronic Lung Disease of Prematurity / Infant, Low Birth Weight / Infant, Small for Gestational Age / Infants, Premature / Newborn Infants1
3CompletedTreatmentChronic Renal Failure With Uremic Nephropathy1
3CompletedTreatmentColorectal Cancers / Metastatic Cancers1
3CompletedTreatmentCongenital Adrenal Hyperplasia (CAH)1
3CompletedTreatmentConjunctivitis, Viral1
3CompletedTreatmentBacterial blepharitis / Conjunctivitis / Corneal Inflammation2
3CompletedTreatmentDiabetic Macular Edema (DME)2
3CompletedTreatmentEffects of Chemotherapy / Multiple Myeloma (MM)1
3CompletedTreatmentEye Dryness1
3CompletedTreatmentFocal Lipoid Glomerulosclerosis / Nephrosis1
3CompletedTreatmentForearm Fractures / Forearm Wound / Hand Fractures / Hand Wound / Surgery of Forearm / Surgery of Hand / Surgery of Wrist / Wrist Fractures / Wrist Wound1
3CompletedTreatmentGlomerulosclerosis, Focal Segmental1
3CompletedTreatmentGraft Versus Host Disease (GVHD) / Oral Manifestations1
3CompletedTreatmentHeadaches / Intranasal Ketamine1
3CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Non-Hodgkin's Lymphoma (NHL)1
3CompletedTreatmentIdiopathic Thrombocytopenic Purpura (ITP)3
3CompletedTreatmentIdiopathic Thrombocytopenic Purpura (ITP) / Purpura1
3CompletedTreatmentImmune Thrombocytopenia1
3CompletedTreatmentInfection NOS / Neutropenias1
3CompletedTreatmentInteraction Between Antiemetic Drugs and Paracetamol1
3CompletedTreatmentKnee Injuries1
3CompletedTreatmentLateral Epicondylitis / Work Related Injury1
3CompletedTreatmentLeukemia, Myelocytic, Acute1
3CompletedTreatmentLeukemias12
3CompletedTreatmentLeukemias / Malignant Lymphomas2
3CompletedTreatmentLeukemias / Myelodysplastic Syndromes1
3CompletedTreatmentLight Chain Deposition Disease / Primary Systemic Amyloidosis1
3CompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
3CompletedTreatmentLung Cancers / Metastatic Cancers1
3CompletedTreatmentLymphohistiocytosis, Hemophagocytic1
3CompletedTreatmentLymphoma, Large-Cell, Diffuse1
3CompletedTreatmentM-Protein / Multiple Myeloma (MM) / Myeloma Proteins / Plasma Cell Myeloma1
3CompletedTreatmentMacular Edema (ME)1
3CompletedTreatmentMacular Edema (ME) / Retinal Vein Occlusions(RVO)2
3CompletedTreatmentMacular Edema (ME) / Uveitis1
3CompletedTreatmentMajor Non-cardiac Surgery1
3CompletedTreatmentMalignancies / Nausea / Vomiting1
3CompletedTreatmentMalignant Lymphomas3
3CompletedTreatmentMigraine2
3CompletedTreatmentMultiple Myeloma (MM)28
3CompletedTreatmentMultiple Myeloma (MM) / Plasma Cell Neoplasms1
3CompletedTreatmentMultiple Myeloma and Plasma Cell Neoplasm6
3CompletedTreatmentMultiple Myeloma and Plasma Cell Neoplasm / Renal Failure1
3CompletedTreatmentMultiple Myeloma de Novo Treatment1
3CompletedTreatmentNeurocysticercosis1
3CompletedTreatmentNonneoplastic Condition1
3CompletedTreatmentOcular Inflammation Associated With Blepharaconjunctivitis1
3CompletedTreatmentPatients Undergoing a Lumbar Slipped Disc Surgery1
3CompletedTreatmentPerennial Allergic Rhinitis (PAR)1
3CompletedTreatmentPost Ocular Surgical Inflammation and Pain1
3CompletedTreatmentPost Ocular Surgical Inflammation and Pain / Post-Surgical Ocular Inflammation / Post-Surgical Ocular Pain2
3CompletedTreatmentPost Operative Pain Management1
3CompletedTreatmentPostoperative pain1
3CompletedTreatmentPrimary Systemic Amyloidosis (AL)1
3CompletedTreatmentProstate Cancer2
3CompletedTreatmentPurpura, Thrombocytopenic, Idiopathic1
3CompletedTreatmentRelapsed Multiple Myeloma1
3CompletedTreatmentRelapsed Or Refractory Multiple Myeloma1
3CompletedTreatmentRelapsed/Refractory Multiple Myeloma1
3CompletedTreatmentRespiratory Distress Syndrome (RDS)1
3CompletedTreatmentRotator Cuff Syndrome / Shoulder Bursitis1
3CompletedTreatmentSoft Tissue Sarcoma (STS)1
3CompletedTreatmentBacterial blepharitis2
3Enrolling by InvitationTreatmentHip Disease1
3Not Yet RecruitingPreventionCesarean Section Complications1
3Not Yet RecruitingPreventionOvarian Hyperstimulation Syndrome1
3Not Yet RecruitingSupportive CareChemotherapy-Induced Nausea and Vomiting (CINV)1
3Not Yet RecruitingSupportive CareChemotherapy-Induced Nausea and Vomiting (CINV) / Colorectal Cancers1
3Not Yet RecruitingSupportive CarePostoperative pain1
3Not Yet RecruitingTreatmentArthropathy of Knee1
3Not Yet RecruitingTreatmentB Acute Lymphoblastic Leukemia / B Lymphoblastic Lymphoma / Blasts More Than 25 Percent of Bone Marrow Nucleated Cells / Central Nervous System Leukemia / Mixed Phenotype Acute Leukemia (MPAL) / Testicular Leukemia1
3Not Yet RecruitingTreatmentHSV Encephalitis1
3Not Yet RecruitingTreatmentIV Drug Usage1
3Not Yet RecruitingTreatmentImmune Thrombocytopenia / Purpura, Thrombocytopenic, Idiopathic1
3Not Yet RecruitingTreatmentLymphohistiocytosis, Hemophagocytic1
3Not Yet RecruitingTreatmentMultiple Myeloma (MM)3
3Not Yet RecruitingTreatmentMultiple Myeloma in Relapse1
3Not Yet RecruitingTreatmentRelapsed or Refractory Acute Myeloid Leukemia1
3RecruitingOtherAsthma Bronchial1
3RecruitingPreventionAdjunct to general anesthesia therapy / Anaesthesia therapy / Analgesics / Analgesics, Opioid / Dexmedetomidine / Gabapentin / Ketamine / Lidocaine / Narcotics / Obstructive Sleep Apnea of Child / Oximetry, Pulse / Pathologic Processes / Physiologic Effects of Drugs / Postoperative Complications / Respiratory Depression / Sleep Disordered Breathing (SDB) / Tonsillectomy1
3RecruitingPreventionAnaesthesia therapy / Ponv / Strabismus1
3RecruitingPreventionChemotherapy-Induced Nausea and Vomiting (CINV)1
3RecruitingPreventionDrug hypersensitivity reaction1
3RecruitingPreventionPain NOS1
3RecruitingSupportive CareCarcinoma, Breast1
3RecruitingSupportive CareDyspnea / Malignant Neoplasms of Independent (Primary) Multiple Sites / Neoplasms, Malignant1
3RecruitingSupportive CareMalignant Neoplasms of Male Genital Organs1
3RecruitingSupportive CareNeoplasms, Malignant2
3RecruitingTreatmentActive, Symptomatic Blepharitis / Bacterial blepharitis / Non-Bacterial Blepharitis1
3RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Acute Lymphocytic Leukemia (ALL) / Leukaemia, Lymphoblastic / Leukemia, Lymphoblastic, Acute, Philadelphia-Positive / Lymphoblastic Leukemia, Acute, Adult / Ph1 Chromosome1
3RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Adult B Acute Lymphoblastic Leukemia / B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative / BCR/ABL1 Fusion Protein Negative / Untreated Adult Acute Lymphoblastic Leukemia1
3RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / B Acute Lymphoblastic Leukemia / B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 / BCR-ABL1 Fusion Protein Expression / Minimal Residual Disease / Philadelphia Chromosome Positive / T Acute Lymphoblastic Leukemia / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
3RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Lymphoma, Lymphoblastic1
3RecruitingTreatmentAcute Lymphoblastic Leukemia, Pediatric2
3RecruitingTreatmentAnaesthesia / Back Pain / Caudal epidural block therapy / Fusion of Spine (Disease) / General Surgery / Local Anesthesia / Postoperative pain1
3RecruitingTreatmentAnesthesia, Conduction / Axillary Brachial Plexus Block / Dexamethasone / Ropivacaine1
3RecruitingTreatmentB Acute Lymphoblastic Leukemia1
3RecruitingTreatmentB Acute Lymphoblastic Leukemia / B Lymphoblastic Lymphoma / Blasts More Than 25 Percent of Bone Marrow Nucleated Cells / Down Syndrome (DS)1
3RecruitingTreatmentB Acute Lymphoblastic Leukemia / Central Nervous System Leukemia / Cognitive Side Effects of Cancer Therapy / Neurotoxicity Syndrome / Osteonecrosis / Pain NOS / Testicular Leukemia / Therapy-Related Toxicity / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
3RecruitingTreatmentBladder Cancers / Transitional Cell Carcinoma / Ureteral Cancer1
3RecruitingTreatmentBronchiolitis1
3RecruitingTreatmentClassical Hodgkin Lymphoma1
3RecruitingTreatmentCochlear Implants / Sensorineural Hearing Loss1
3RecruitingTreatmentConjunctivitis, Seasonal Allergic1
3RecruitingTreatmentDrug-Induced Liver Injury / Human Immunodeficiency Virus (HIV) / IRIS / Tuberculosis Infection / Tuberculous Meningitis1
3RecruitingTreatmentDrug-Induced Liver Injury / Tuberculosis Infection / Tuberculous Meningitis1
3RecruitingTreatmentExtranodal NK-T-Cell Lymphoma, Nasal Type1
3RecruitingTreatmentExtranodal NK-T-Cell Lymphoma, Nasal and Nasal-Type1
3RecruitingTreatmentExtranodal NK/T-cell Lymphoma, Nasal Type1
3RecruitingTreatmentHepatocellular,Carcinoma1
3RecruitingTreatmentInflammation and Pain Associated With Cataract Surgery1
3RecruitingTreatmentInflammatory Macular Edema1
3RecruitingTreatmentLymphoblastic Lymphoma, Childhood1
3RecruitingTreatmentLymphohistiocytosis, Hemophagocytic1
3RecruitingTreatmentLymphoma, Lymphoblastic1
3RecruitingTreatmentMacular Edema (ME) / Uveitis1
3RecruitingTreatmentMalignant Lymphomas1
3RecruitingTreatmentMature B-cell Non-Hodgkin Lymphoma1
3RecruitingTreatmentMenière's Disease2
3RecruitingTreatmentMetastatic Colorectal Cancers1
3RecruitingTreatmentMultiple Myeloma (MM)17
3RecruitingTreatmentMultiple Myeloma (MM) / New Diagnosis Tumor1
3RecruitingTreatmentMultiple Myeloma in Relapse / Refractory Multiple Myeloma1
3RecruitingTreatmentNatural Killer/T-Cell Lymphoma, Nasal and Nasal-Type / Non-Hodgkin T-cell Lymphoma / Non-Hodgkin's Lymphoma, Relapsed1
3RecruitingTreatmentNeuroblastomas / Opsoclonus Myoclonus Syndrome1
3RecruitingTreatmentNewly Diagnosed Multiple Myeloma2
3RecruitingTreatmentNon-Hodgkin's Lymphoma (NHL)1
3RecruitingTreatmentPain NOS1
3RecruitingTreatmentPlasma Cell Myeloma / Stage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
3RecruitingTreatmentPlasmacytoma1
3RecruitingTreatmentPost-Operative Nausea and Vomiting (PONV)1
3RecruitingTreatmentPostoperative pain1
3RecruitingTreatmentProstatic Neoplasms1
3RecruitingTreatmentPurpura, Thrombocytopenic, Idiopathic1
3RecruitingTreatmentRelapsed Or Refractory Multiple Myeloma1
3RecruitingTreatmentSmoldering Plasma Cell Myeloma1
3SuspendedTreatmentCongenital Adrenal Hyperplasia (CAH)1
3SuspendedTreatmentPhiladelphia Chromosome Positive Adult Acute Lymphoblastic Leukemia1
3SuspendedTreatmentRelapsed/Refractory Multiple Myeloma1
3TerminatedHealth Services ResearchFollicular Lymphoma (FL)1
3TerminatedPreventionChemotherapy-Induced Nausea and Vomiting (CINV)1
3TerminatedSupportive CareHeadaches / Vomiting1
3TerminatedTreatmentAcute Fungal Otitis Externa1
3TerminatedTreatmentAcute Lymphoblastic Leukaemias (ALL)1
3TerminatedTreatmentAcute Otitis Externa1
3TerminatedTreatmentChronic Lung Disease of Prematurity / Infant, Low Birth Weight / Infant, Small for Gestational Age / Infants, Premature / Newborn Infants / Respiratory Distress Syndrome (RDS)1
3TerminatedTreatmentCrohn's Disease (CD)1
3TerminatedTreatmentAcute nonspecific tenosynovitis / DeQuervain's Tenosynovitis / Inflammatory Diseases / Lateral Epicondylitis / Trigger Finger1
3TerminatedTreatmentDysphagia After Anterior Cervical Decompression and Fusion of the Spine1
3TerminatedTreatmentImmune Thrombocytopenic Purpura ( ITP )1
3TerminatedTreatmentLiver Cirrhosis1
3TerminatedTreatmentMalignant Lymphomas2
3TerminatedTreatmentMenière's Disease3
3TerminatedTreatmentMultiple Myeloma (MM)6
3TerminatedTreatmentOtitis Externa1
3TerminatedTreatmentOtitis Media in Patients With Tympanostomy Tubes1
3TerminatedTreatmentProstate Cancer1
3TerminatedTreatmentSickle Cell Disorders1
3TerminatedTreatmentStage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
3TerminatedTreatmentVomiting2
3Unknown StatusPreventionDrug hypersensitivity reaction1
3Unknown StatusPreventionNausea / Vomiting1
3Unknown StatusPreventionRespiratory; Disorder, Functional, Impaired1
3Unknown StatusSupportive CareMalignancies1
3Unknown StatusTreatmentAcute Bacterial Conjunctivitis1
3Unknown StatusTreatmentAcute Lymphoblastic Leukaemias (ALL)1
3Unknown StatusTreatmentAcute Otitis Externa1
3Unknown StatusTreatmentAcute / Conjunctivitis, Bacterial1
3Unknown StatusTreatmentAllergies / Skin Inflammation1
3Unknown StatusTreatmentBacterial Vaginosis (BV) / Fungal Vaginal Infections1
3Unknown StatusTreatmentExtramedullary Plasmacytoma1
3Unknown StatusTreatmentHELLP Syndrome1
3Unknown StatusTreatmentLeukemias2
3Unknown StatusTreatmentLeukemias / Malignant Lymphomas1
3Unknown StatusTreatmentMacular Edema (ME) / Retinal Vein Occlusions(RVO)1
3Unknown StatusTreatmentMalignant Lymphomas7
3Unknown StatusTreatmentMantle Cell Lymphoma (MCL)1
3Unknown StatusTreatmentMultiple Myeloma (MM)4
3Unknown StatusTreatmentMultiple Myeloma and Plasma Cell Neoplasm2
3Unknown StatusTreatmentNonneoplastic Condition1
3Unknown StatusTreatmentOral Lichen Planus1
3Unknown StatusTreatmentPost-Operative Pain1
3Unknown StatusTreatmentSarcoidosis1
3Unknown StatusTreatmentVitreoretinopathy, Proliferative1
3Unknown StatusTreatmentDiffuse posterior uveitis1
3Unknown StatusTreatmentNeurocostal neuralgia1
3Unknown StatusTreatmentPostoperative paralytic ileus1
3WithdrawnSupportive CareChemotherapy-Induced Nausea and Vomiting (CINV) / Malignancies / Nausea and vomiting / Solid Tumor Cancers1
3WithdrawnTreatmentBlepharoconjunctivitis1
3WithdrawnTreatmentCancer - Small Cell Lung Cancer / Lung Cancer Small Cell Lung Cancer (SCLC)1
3WithdrawnTreatmentCataracts1
3WithdrawnTreatmentDisorder of Rotator Cuff / Disorder of Shoulder / Disorder of Tendon of Biceps / Injury of Shoulder Region / Shoulder Pain1
3WithdrawnTreatmentIdiopathic Thrombocytopenic Purpura (ITP) / Purpura2
3WithdrawnTreatmentImmune Thrombocytopenia1
3WithdrawnTreatmentMultiple Myeloma (MM)1
3WithdrawnTreatmentOther Complications of Obstetric Anesthesia - Delivered / Pain, Obstetric1
3WithdrawnTreatmentPost-surgical Inflammation1
3WithdrawnTreatmentSkin Inflammation1
4Active Not RecruitingOtherTonsillectomy1
4Active Not RecruitingPreventionPost-Craniotomy Headache / Postoperative pain1
4Active Not RecruitingPreventionPostoperative Cognitive Dysfunction1
4Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL)1
4Active Not RecruitingTreatmentEarly-Stage Breast Cancer / Pain Syndrome1
4Active Not RecruitingTreatmentExacerbation of Ulcerative Colitis / Granulomatous Colitis / Ulcerative Colitis, Active Severe1
4Active Not RecruitingTreatmentMedical Induction of Labor Affecting Fetus1
4Active Not RecruitingTreatmentModified Radical Mastectomy1
4Active Not RecruitingTreatmentMultiple Myeloma (MM)2
4Active Not RecruitingTreatmentOpen-angle Glaucoma (OAG)1
4Active Not RecruitingTreatmentPain, Radiating1
4Active Not RecruitingTreatmentPediatric Post-tonsillectomy Pain1
4Active Not RecruitingTreatmentCaudal epidural block therapy / Shoulder Surgery1
4Active Not RecruitingTreatmentVomiting2
4CompletedNot AvailablePain NOS1
4CompletedNot AvailablePostoperative pain1
4CompletedBasic ScienceCancer of the Ovary1
4CompletedBasic ScienceCataracts1
4CompletedBasic SciencePremature Births1
4CompletedDiagnosticConjunctivitis, Seasonal Allergic1
4CompletedHealth Services ResearchBronchiolitis1
4CompletedOtherPain NOS / Shoulder Arthroscopy1
4CompletedPreventionAcute Leukemic Patients in Children1
4CompletedPreventionArterial Hypotension1
4CompletedPreventionArthrosis, Unspecified, Ankle and Foot1
4CompletedPreventionChronic Obstructive Pulmonary Disease (COPD)2
4CompletedPreventionCisplatin Ototoxicity1
4CompletedPreventionEndophthalmitis Postoperative1
4CompletedPreventionFoot and Ankle Procedures1
4CompletedPreventionFractures, Bone / Morphine Adverse Reaction / Nausea and Vomiting, Postoperative / Pruritus / Satisfaction, Personal1
4CompletedPreventionHypospadias / Postoperative pain1
4CompletedPreventionKeloid Scars1
4CompletedPreventionMigraine2
4CompletedPreventionNausea / Neoplasms / Vomiting1
4CompletedPreventionNausea / Postoperative Nausea and Vomiting (PONV)1
4CompletedPreventionNausea / Vomiting2
4CompletedPreventionOedema1
4CompletedPreventionPain Measurement1
4CompletedPreventionPain NOS / Throat Pain1
4CompletedPreventionPost-Operative Nausea and Vomiting (PONV)8
4CompletedPreventionPost-Operative Nausea and Vomiting (PONV) / Postoperative pain1
4CompletedPreventionPostoperative Cognitive Dysfunction1
4CompletedPreventionPostoperative pain1
4CompletedPreventionPreterm Delivery1
4CompletedPreventionShivering2
4CompletedPreventionThroat Pain1
4CompletedPreventionVomiting1
4CompletedSupportive CareCaudal Block1
4CompletedSupportive CareFracture, Ankle1
4CompletedSupportive CareInterscalene Blockade in Elective Arthroscopic Rotator Cuff Repair / Shoulder Injury1
4CompletedSupportive CareMalignancies / Tumors1
4CompletedSupportive CarePonv1
4CompletedSupportive CarePostoperative pain1
4CompletedTreatmentAbdominal Surgeries / Analgesia, Patient-Controlled / Analgesia, Postoperative / Postoperative pain1
4CompletedTreatmentAcute Lymphoblastic Leukaemias (ALL)3
4CompletedTreatmentAcute Respiratory Distress Syndrome (ARDS)1
4CompletedTreatmentAdult Acute Lymphocytic Leukemia4
4CompletedTreatmentAge-Related Macular Degeneration (ARMD)1
4CompletedTreatmentAmbulatory Surgical Procedures / Brachial Plexus Block / Postoperative pain / Shoulder Joint Disorder1
4CompletedTreatmentAnaesthetics Gases, Xenon / Anaesthetics Volatile, Sevoflurane / Depth of Anaesthesia / Post-Operative Nausea and Vomiting (PONV)1
4CompletedTreatmentAnalgesia, Postoperative / Postoperative Complications1
4CompletedTreatmentAnterior Cruciate Ligament Reconstruction / Regional Anesthesia, Saphenous Nerve Block1
4CompletedTreatmentArthritis / Shoulder Impingement Syndrome1
4CompletedTreatmentAsthma Acute / Asthma Bronchial1
4CompletedTreatmentAsthma Bronchial / Reactive Airways Disease (RAD)1
4CompletedTreatmentAtypical Facial Pain / Typical Facial Pain1
4CompletedTreatmentBack Pain Lower Back / Spinal Stenosis1
4CompletedTreatmentBlepharokeratoconjunctivitis1
4CompletedTreatmentBurkitt's Lymphoma / Large Cell Anaplastic Lymphoma / Lymphoma, Lymphoblastic / Mediastinal Neoplasms1
4CompletedTreatmentCancer, Breast / Dexamethasone / Glucocorticoid therapy / Mastectomy / Nausea and Vomiting, Postoperative / Postoperative Complications / Postoperative pain / Steroid / Systemic Inflammatory Response Syndrome (SIRS)1
4CompletedTreatmentCataracts1
4CompletedTreatmentCataracts / Cystoid Macular Edema Following Cataract Surgery / Diabetic Macular Edema (DME) / Macular Edema, Cystoid / Vision Disorders1
4CompletedTreatmentCataracts / Pseudoexfoliation Syndrome1
4CompletedTreatmentCroup1
4CompletedTreatmentDepressive Symptoms1
4CompletedTreatmentDiabetic Macular Edema (DME)4
4CompletedTreatmentDiabetic Macular Edema (DME) / Epiretinal Membrane1
4CompletedTreatmentDisorder of Shoulder / Postoperative pain1
4CompletedTreatmentEpithelial Defect After Phototherapeutic Keratectomy1
4CompletedTreatmentGraves' Disease1
4CompletedTreatmentHip Dysplasia / Postoperative Complications1
4CompletedTreatmentImpacted Third Molar Tooth1
4CompletedTreatmentIncomplete Reversal of Neuromuscular Block1
4CompletedTreatmentInflammation Eye1
4CompletedTreatmentInflammatory Reaction1
4CompletedTreatmentIntraocular Pressure1
4CompletedTreatmentKnee Osteoarthritis (Knee OA)2
4CompletedTreatmentLocal Anesthesia1
4CompletedTreatmentLung Cancers1
4CompletedTreatmentLymphoma, Lymphoblastic1
4CompletedTreatmentMacular Edema (ME) / Retinal Vein Occlusions(RVO)2
4CompletedTreatmentMacular Edema (ME) / Uveitis1
4CompletedTreatmentMacular Edema Caused by Retinal Vein Occlusion1
4CompletedTreatmentMultiple Myeloma (MM)1
4CompletedTreatmentNarcotic Use / Nausea / Occasional Constipation / Pain NOS1
4CompletedTreatmentNasal Surgery1
4CompletedTreatmentNausea and vomiting / Post Operative Pain1
4CompletedTreatmentNausea / Vomiting2
4CompletedTreatmentNonvalvular Atrial Fibrillation / Surgery, Cardiac1
4CompletedTreatmentOcular Hypertension / Open-angle Glaucoma (OAG)1
4CompletedTreatmentOsteoarthritis (OA)1
4CompletedTreatmentOsteoarthritis, Hip1
4CompletedTreatmentPain NOS1
4CompletedTreatmentPain NOS / Peripheral Nerve Blocks1
4CompletedTreatmentPain NOS / Postoperative1
4CompletedTreatmentPain NOS / Pterygium1
4CompletedTreatmentPain NOS / Shoulder Arthroscopy1
4CompletedTreatmentCaudal epidural block therapy / Pain NOS / Total Knee Arthroplasty (TKA)1
4CompletedTreatmentPain, Acute / Pain, Chronic1
4CompletedTreatmentPeripheral Arterial Disease (PAD)1
4CompletedTreatmentPost Traumatic Stress Disorder (PTSD)1
4CompletedTreatmentPost-Operative Nausea and Vomiting (PONV)1
4CompletedTreatmentPostoperative Complications1
4CompletedTreatmentPostoperative Sore Throat, Cough, Hoarseness1
4CompletedTreatmentPostoperative pain4
4CompletedTreatmentProstate Cancer1
4CompletedTreatmentPurpura, Thrombocytopenic, Idiopathic1
4CompletedTreatmentRecession, Gingival1
4CompletedTreatmentRecurrent Pterygium of Eye / Steroid-Induced Glaucoma1
4CompletedTreatmentRetinal Vein Occlusions(RVO)1
4CompletedTreatmentRupture of Anterior Cruciate Ligament1
4CompletedTreatmentSjögren's Syndrome1
4CompletedTreatmentTemporomandibular Disorders1
4CompletedTreatmentTotal Knee Arthroplasty (TKA)1
4CompletedTreatmentTrigger Finger Disorder1
4CompletedTreatmentDiffuse posterior uveitis / Uveitis, Intermediate1
4CompletedTreatmentVernal Keratoconjunctivitis1
4CompletedTreatmentViral Bronchiolitis1
4CompletedTreatmentVital Pulp Therapy1
4Enrolling by InvitationTreatmentAsthma Childhood1
4Enrolling by InvitationTreatmentSacro-Iliac Spondylosis1
4Not Yet RecruitingOtherACL Injury1
4Not Yet RecruitingOtherSystemic Inflammatory Response Syndrome (SIRS)1
4Not Yet RecruitingPreventionNausea and Vomiting, Postoperative1
4Not Yet RecruitingPreventionPost-Operative Nausea and Vomiting (PONV)1
4Not Yet RecruitingSupportive CareDiabetes Mellitus (DM)1
4Not Yet RecruitingTreatmentAddison's Disease1
4Not Yet RecruitingTreatmentArthroplasty, Knee Replacement / Postoperative pain1
4Not Yet RecruitingTreatmentClinically Significant Macular Edema Due to Diabetes Mellitus1
4Not Yet RecruitingTreatmentDiabetic Macular Edema (DME)1
4Not Yet RecruitingTreatmentDiabetic Macular Edema (DME) / Retinal Ischemia / Retinopathy, Diabetic1
4Not Yet RecruitingTreatmentEncephalitis, Viral1
4Not Yet RecruitingTreatmentGlaucoma1
4Not Yet RecruitingTreatmentImmune Thrombocytopenia1
4Not Yet RecruitingTreatmentMalignancies / Nausea / Vomiting1
4Not Yet RecruitingTreatmentOtitis Media (OM) / Otorrhoea1
4Not Yet RecruitingTreatmentPost-Operative Nausea and Vomiting (PONV)1
4Not Yet RecruitingTreatmentSurgery, Oral1
4Not Yet RecruitingTreatmentTuberculous Meningitis1
4Not Yet RecruitingTreatmentPh+ Acute Lymphoblastic Leukemia1
4RecruitingNot AvailableLung Cancers1
4RecruitingBasic ScienceCritical Limb Ischemia (CLI) / Peripheral Artery Disease (PAD) / Vascular Diseases1
4RecruitingBasic ScienceInsulin Secretion1
4RecruitingOtherAllogenic Granulocyte Donation / Blood Component Removal / Blood Donors / Granulocyte Colony-Stimulation Factor / Leukocyte Transfusion1
4RecruitingOtherHand Injury Wrist / Peripheral Nerve Block Prolongation1
4RecruitingPreventionAsthma Bronchial / Inflammatory Reaction1
4RecruitingPreventionChemotherapy-Induced Nausea and Vomiting (CINV)1
4RecruitingPreventionChildren / Postoperative pain1
4RecruitingPreventionDelirium / Postoperative Cognitive Dysfunction1
4RecruitingPreventionHyaline Membrane Disease / Necrotizing Enterocolitis of Newborn1
4RecruitingPreventionLaparoscopic Sleeve Gastrectomy / Post-Operative Nausea and Vomiting (PONV)1
4RecruitingPreventionNeuritis / Radioiodine ablation of thyroid tissue1
4RecruitingPreventionPost-Operative Nausea and Vomiting (PONV)1
4RecruitingPreventionPostoperative Complications1
4RecruitingPreventionPostoperative pain1
4RecruitingPreventionPremature Births1
4RecruitingPreventionSwallowing Disorders1
4RecruitingSupportive CareAnaesthesia therapy / Anesthesia Intubation Complications / Anesthesia; Adverse Effect1
4RecruitingSupportive CareDexamethasone / Epidural Block / General Surgery / Malignant Neoplasm of Pancreas / Overall Survival1
4RecruitingSupportive CareObstructive Sleep Apnea (OSA)1
4RecruitingSupportive CarePain Management1
4RecruitingSupportive CareTonsillitis1
4RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL)3
4RecruitingTreatmentAnalgesia, Postoperative1
4RecruitingTreatmentAnterior Cruciate Ligament Injury1
4RecruitingTreatmentAsthma Bronchial / Croup1
4RecruitingTreatmentBranch Retinal Vein Occlusion With Macular Edema1
4RecruitingTreatmentBreast Pain / Effect of Drugs / Local Anesthesia1
4RecruitingTreatmentCataracts / Diabetic Macular Edema (DME)1
4RecruitingTreatmentCatastrophizing Pain / General Surgery / Knee Osteoarthritis (Knee OA) / Opioids Use / Pain, Chronic / Perioperative/Postoperative Complications / Post-Operative Nausea and Vomiting (PONV) / Postoperative pain1
4RecruitingTreatmentCatastrophizing Pain / General Surgery / Opioids Use / Osteoarthritis, Hip / Pain, Chronic / Perioperative/Postoperative Complications / Post-Operative Nausea and Vomiting (PONV) / Postoperative pain1
4RecruitingTreatmentCentral Retinal Vein Occlusion (CRVO) / Macular Edema (ME)1
4RecruitingTreatmentChronic Obstructive Pulmonary Disease (COPD) / Heart Failure1
4RecruitingTreatmentChronic Pain Post-Proceduraal / Nausea and Vomiting, Postoperative / Postoperative pain1
4RecruitingTreatmentColorectal Cancers / Crohn's Disease (CD) / Digestive System Diseases / Gastrointestinal Cancers / Gastrointestinal Diseases / Inflammatory Bowel Diseases (IBD) / Intestinal Diseases / Pain NOS / Pain, Neuropathic / Postoperative pain1
4RecruitingTreatmentCongenital Adrenal Hyperplasia (CAH)1
4RecruitingTreatmentDexamethasone Effect on Induction of Labor1
4RecruitingTreatmentDexamethasone / Supraclavicular Brachial Plexus Block1
4RecruitingTreatmentDiabetes Mellitus (DM) / Macular Edema (ME) / Retinal Exudates and Deposits1
4RecruitingTreatmentDiabetic Macular Edema (DME)2
4RecruitingTreatmentDistal Radius Fractures1
4RecruitingTreatmentGeneral Surgery / Knee Osteoarthritis (Knee OA) / Perioperative/Postoperative Complications / Post-Operative Nausea and Vomiting (PONV) / Postoperative pain1
4RecruitingTreatmentHeadaches1
4RecruitingTreatmentImmune Thrombocytopenia2
4RecruitingTreatmentInflammatory Reaction / Intraocular Pressure1
4RecruitingTreatmentInflammatory Reaction / Osteoarthritis (OA) / Postoperative pain1
4RecruitingTreatmentInflammatory Responses1
4RecruitingTreatmentKnee Osteoarthritis (Knee OA)1
4RecruitingTreatmentKnee Replacement Surgery1
4RecruitingTreatmentLocalized Primary Osteoarthritis of Both Hips (Diagnosis) / Osteoarthritis, Hip1
4RecruitingTreatmentLower Limb Injury / Postoperative pain1
4RecruitingTreatmentMacular Edema (ME) / Retinal Vein Occlusions(RVO)1
4RecruitingTreatmentMalignancies1
4RecruitingTreatmentMantle Cell Lymphoma (MCL)1
4RecruitingTreatmentMetastatic Hormone Refractory Prostate Cancer1
4RecruitingTreatmentMultiple Myeloma (MM)3
4RecruitingTreatmentMyofascial Pain Syndrome1
4RecruitingTreatmentNasal and Nasal-type NK/T-cell Lymphoma1
4RecruitingTreatmentOpioid Use, Unspecified1
4RecruitingTreatmentOrthopedic Surgeries1
4RecruitingTreatmentOsteoarthritis (OA) / Postoperative pain1
4RecruitingTreatmentOsteoarthritis of the Shoulder / Pain Management / Post-Operative Pain / Total Shoulder Arthroplasty1
4RecruitingTreatmentPain, Acute1
4RecruitingTreatmentPain, Chronic1
4RecruitingTreatmentPeripheral T Cell Lymphoma (PTCL)1
4RecruitingTreatmentPost-Operative Nausea and Vomiting (PONV)1
4RecruitingTreatmentPostherpetic Neuralgia1
4RecruitingTreatmentPostoperative pain4
4RecruitingTreatmentPostoperative pain / Rotator Cuff Syndrome1
4RecruitingTreatmentPostoperative pain / Urethral Strictures1
4RecruitingTreatmentCaudal epidural block therapy / Postoperative pain1
4RecruitingTreatmentPrimary Central Nervous System Lymphoma (PCNSL)1
4RecruitingTreatmentRadiculopathy, Cervical1
4RecruitingTreatmentRelapsed Refractory Multiple Myeloma1
4RecruitingTreatmentRelapsed and/or Refractory Multiple Myeloma1
4RecruitingTreatmentRobotic Lung Surgery1
4RecruitingTreatmentShoulder Pain1
4RecruitingTreatmentTrigger Finger1
4RecruitingTreatmentVideo-assisted Thoracic Surgery (VATS) / Video-assisted Thoracoscopic Surgery (VATS)1
4TerminatedPreventionAnesthesia, Pediatrics, Surgery1
4TerminatedPreventionDelirium / Dexamethasone / Flubiprofen Axetil / Lung Cancer Non-Small Cell Cancer (NSCLC) / Surgery--Complications1
4TerminatedPreventionPost-Operative Nausea and Vomiting (PONV) / Postoperative pain1
4TerminatedSupportive CareDexamethasone / Flubiprofen Axetil / General Surgery / Long-Term Effects Secondary to Cancer Therapy in Adults / Lung Cancer Non-Small Cell Cancer (NSCLC)1
4TerminatedTreatmentAbdominal Pain (AP) / Nausea1
4TerminatedTreatmentAsthma Bronchial / Status Asthmaticus / Wheezing1
4TerminatedTreatmentCommunity Acquired Pneumonia (CAP)1
4TerminatedTreatmentDiabetic Macular Edema (DME)1
4TerminatedTreatmentDuration of Pain Relief1
4TerminatedTreatmentGeneral Surgery1
4TerminatedTreatmentHELLP Syndrome1
4TerminatedTreatmentHematoma, Subdural, Chronic1
4TerminatedTreatmentHip Fractures1
4TerminatedTreatmentKidney Diseases / Postoperative Complications1
4TerminatedTreatmentPain NOS1
4TerminatedTreatmentPostoperative pain2
4TerminatedTreatmentTrigger Finger Disorder1
4TerminatedTreatmentTumors1
4Unknown StatusTreatmentAcute Lymphoblastic Leukaemias (ALL) / Non-Hodgkin's Lymphoma (NHL)1
4Unknown StatusTreatmentAdult Acute Lymphocytic Leukemia2
4Unknown StatusTreatmentArthritis1
4Unknown StatusTreatmentChronic Rhinosinusitis1
4Unknown StatusTreatmentFracture of Neck of Femur1
4Unknown StatusTreatmentInfertilities1
4Unknown StatusTreatmentMultiple Myeloma (MM)1
4Unknown StatusTreatmentPost Minimally Invasive Thorascopic Surgical Pain1
4Unknown StatusTreatmentPostoperative pain1
4WithdrawnNot AvailableAdrenal Insufficiency1
4WithdrawnSupportive CareRetinal Detachment1
4WithdrawnTreatmentAnalgesia Duration1
4WithdrawnTreatmentAntibody Mediated Rejection / End Stage Renal Disease (ESRD)1
4WithdrawnTreatmentBronchiolitis Acute1
4WithdrawnTreatmentCorneal Endothelial Cell Loss / Corneal Endothelial Decompensation / Dexamethasone Adverse Reaction / Diabetes Mellitus (DM)1
4WithdrawnTreatmentImmune Thrombocytopenia1
4WithdrawnTreatmentNeuromuscular Blockade1
4WithdrawnTreatmentOtitis Media With Effusion in Children / Otorrhoea1
4WithdrawnTreatmentPain NOS / Total Knee Arthroplasty (TKA)1
4WithdrawnTreatmentPost Operative Pain Control1
4WithdrawnTreatmentRadiculopathy, Cervical1
4WithdrawnTreatmentSpinal Stenosis of Lumbar Region1
Not AvailableActive Not RecruitingNot AvailableRelapsed and/or Refractory Multiple Myeloma1
Not AvailableActive Not RecruitingSupportive CareCancer, Breast / Post-Operative Nausea and Vomiting (PONV)1
Not AvailableActive Not RecruitingTreatmentMalignant Lymphomas1
Not AvailableApproved for MarketingNot AvailableMultiple Myeloma (MM)1
Not AvailableAvailableNot AvailableMultiple Myeloma (MM)2
Not AvailableAvailableNot AvailableMultiple Myeloma (MM) / Multiple Myeloma in Relapse / Refractory Multiple Myeloma / Relapsed Multiple Myeloma1
Not AvailableCompletedNot AvailableAdenotonsillectomy / Tonsillectomy1
Not AvailableCompletedNot AvailableAmyloidosis1
Not AvailableCompletedNot AvailableDiabetic Macular Edema (DME)4
Not AvailableCompletedNot AvailableGlucose tolerance impaired / Insulin Resistance1
Not AvailableCompletedNot AvailableHealthy Volunteers1
Not AvailableCompletedNot AvailableMacular Edema (ME)4
Not AvailableCompletedNot AvailableMacular Edema (ME) / Retinal Vein Occlusions(RVO)3
Not AvailableCompletedNot AvailableDiffuse posterior uveitis / Macular Edema (ME) / Retinal Vein Occlusions(RVO)1
Not AvailableCompletedNot AvailableMacular Edema (ME) / Visual Acuity1
Not AvailableCompletedNot AvailableMacular Oedema / Retinal Vein Occlusions(RVO)1
Not AvailableCompletedNot AvailableMultiple Myeloma (MM)1
Not AvailableCompletedNot AvailableNeuromuscular Blockade1
Not AvailableCompletedNot AvailablePain NOS1
Not AvailableCompletedNot AvailableRetinal Vein Occlusions(RVO)1
Not AvailableCompletedNot AvailableUpper Extremity Fractures / Upper Extremity Surgery1
Not AvailableCompletedBasic ScienceAnterior Uveitis (AU) / Iridocyclitis / Iritis / Macular Edema (ME) / Uveitis1
Not AvailableCompletedBasic ScienceAsthma Bronchial / Corticosteroid Insensitivity / Smoking / Steroid Resistance1
Not AvailableCompletedBasic ScienceExperimental Lung Inflammation1
Not AvailableCompletedBasic ScienceHealthy Volunteers1
Not AvailableCompletedBasic SciencePost Traumatic Stress Disorder (PTSD)1
Not AvailableCompletedBasic SciencePosttraumatic Stress Disorders1
Not AvailableCompletedBasic ScienceType 2 Diabetes Mellitus1
Not AvailableCompletedOtherLower Abdominal Oncologic Surgery1
Not AvailableCompletedOtherLumbosacral Radicular Pain1
Not AvailableCompletedOtherProlonged Motor Block / Prolonged Sensory Block / Spinal Anaesthesia1
Not AvailableCompletedPreventionBlood Diseases / Graft Versus Host Disease (GVHD) / Hematopoietic Stem Cell Transplantation (HSCT) / Leukemias / Multiple Myeloma (MM) / Myelodysplastic Syndromes / Transplantation, Bone Marrow1
Not AvailableCompletedPreventionCataracts1
Not AvailableCompletedPreventionCesarean Section / Pruritus1
Not AvailableCompletedPreventionEndometriosis of Uterus / Uterine Leiomyomas1
Not AvailableCompletedPreventionGynecological Disease1
Not AvailableCompletedPreventionInflammation Following Cataract Surgery1
Not AvailableCompletedPreventionInflammatory Reaction1
Not AvailableCompletedPreventionNausea and vomiting / Post Operative Nausea and Vomiting (PONV)1
Not AvailableCompletedPreventionOrthopedic Procedures1
Not AvailableCompletedPreventionPost Lasik Surgery Inflammation1
Not AvailableCompletedPreventionPost Operative Sore Throat1
Not AvailableCompletedPreventionPost-Operative Nausea and Vomiting (PONV)8
Not AvailableCompletedPreventionPrevention of Hypersensitivity Reactions to Paclitaxel1
Not AvailableCompletedPreventionSwallowing Disorders1
Not AvailableCompletedPreventionTransient Tachypnea of the Newborn1
Not AvailableCompletedPreventionWound Infections1
Not AvailableCompletedScreeningPolycystic Ovaries Syndrome1
Not AvailableCompletedSupportive CareCachexia; Cancer1
Not AvailableCompletedSupportive CareCancer of the Ovary / Cancer, Breast / Chronic Myeloproliferative Disorders / Gestational Trophoblastic Disease / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Neoplasms / Nausea and vomiting / Neuroblastomas / Testicular germ cell tumour1
Not AvailableCompletedSupportive CareLower Extremities Fracture1
Not AvailableCompletedSupportive CareMale Breast Cancer / Nausea and vomiting / Stage I Breast Carcinoma / Stage II Breast Cancer / Stage IIIA Breast Cancer1
Not AvailableCompletedSupportive CareMalignancies1
Not AvailableCompletedSupportive CareMultiple Myeloma (MM)1
Not AvailableCompletedSupportive CareNausea / Sarcomas / Vomiting1
Not AvailableCompletedSupportive CareNeoplasms, Malignant1
Not AvailableCompletedSupportive CarePain NOS1
Not AvailableCompletedSupportive CarePain NOS / Recurrent Oropharyngeal Squamous Cell Carcinoma / Stage I Oropharyngeal Squamous Cell Carcinoma / Stage II Oropharyngeal Squamous Cell Carcinoma / Stage III Oropharyngeal Squamous Cell Carcinoma / Swallowing Disorders1
Not AvailableCompletedTreatmentAdult Patients Undergoing Elective Surgery With General Anesthesia and LMA Insertion1
Not AvailableCompletedTreatmentAdverse Effects of Medical Drugs / Chemotherapy-Induced Nausea and Vomiting (CINV) / Effects of Chemotherapy / Sarcomas1
Not AvailableCompletedTreatmentAmyloidosis / Leukemias1
Not AvailableCompletedTreatmentAmyloidosis / Light Chain and Heavy Chain Deposition Disease (LHCDD or MIDD) / Light Chain Deposition Disease (LCDD or MIDD) / Monoclonal Immunoglobulin Deposition Disease (MIDD)1
Not AvailableCompletedTreatmentAnaesthesia therapy1
Not AvailableCompletedTreatmentAnal Condyloma / Fissure in Ano / Hemorrhoids / Rectal Fistulas1
Not AvailableCompletedTreatmentAnalgesia, Postoperative1
Not AvailableCompletedTreatmentAnalgesia / Postoperative pain1
Not AvailableCompletedTreatmentApnea, Obstructive / Hearing loss or impairment / Nasal Obstruction / Nasopharyngeal Obstruction / Otitis / Snoring1
Not AvailableCompletedTreatmentAsthma Bronchial1
Not AvailableCompletedTreatmentAsthma Bronchial / Reactive Airways Disease (RAD)1
Not AvailableCompletedTreatmentAtaxia-Telangiectasia1
Not AvailableCompletedTreatmentAtrioventricular Nodal Dysfunction / Congenital Heart Block / Myocardial Injury / Neonatal Lupus1
Not AvailableCompletedTreatmentB-cell Adult Acute Lymphoblastic Leukemia / B-cell Childhood Acute Lymphoblastic Leukemia / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia2
Not AvailableCompletedTreatmentBack Pain / Cervical Pain1
Not AvailableCompletedTreatmentCardiac Diseases / Postoperative Complications / Systemic Inflammatory Response Syndrome (SIRS)1
Not AvailableCompletedTreatmentCataracts4
Not AvailableCompletedTreatmentCataracts / Glaucoma1
Not AvailableCompletedTreatmentCentral Retinal Vein Occlusion (CRVO) / Macular Edema (ME)1
Not AvailableCompletedTreatmentCervical Spine1
Not AvailableCompletedTreatmentChalazion Both Eyes / Chalazion Left Eye, Unspecified Eyelid / Chalazion Right Eye, Unspecified Eyelid / Chalazion Unspecified Eye, Unspecified Eyelid1
Not AvailableCompletedTreatmentClinically Significant Macular Edema / Diabetic Macular Edema (DME) / Macular Edema, Cystoid / Vision Disorders1
Not AvailableCompletedTreatmentCognition Disorders / Cortisol; Hypersecretion / Femoral Fractures1
Not AvailableCompletedTreatmentCorneal Diseases1
Not AvailableCompletedTreatmentCysticercosis / Epilepsies1
Not AvailableCompletedTreatmentDiabetic Macular Edema (DME) / Vision Disorders1
Not AvailableCompletedTreatmentDry Eye Syndrome (DES)1
Not AvailableCompletedTreatmentDry Eye Syndrome (DES) / Keratoconjunctivitis Sicca1
Not AvailableCompletedTreatmentGeneral Surgery1
Not AvailableCompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Non-Hodgkin's Lymphoma (NHL)1
Not AvailableCompletedTreatmentImpaired Fasting Glucose (IFG) / Impaired Glucose Tolerance (IGT) / Pre-Diabetic1
Not AvailableCompletedTreatmentIntraventricular Hemorrhage / Neonatal Mortality / Respiratory Distress Syndrome (RDS)1
Not AvailableCompletedTreatmentLateral Elbow Pain1
Not AvailableCompletedTreatmentLeukemias3
Not AvailableCompletedTreatmentLymphoma, Large Cell / Non-Hodgkin's Lymphoma (NHL)1
Not AvailableCompletedTreatmentLymphoma, Lymphoblastic1
Not AvailableCompletedTreatmentMicrovascular Decompression Surgery / Post-Operative Nausea and Vomiting (PONV)1
Not AvailableCompletedTreatmentMultiple Myeloma (MM)1
Not AvailableCompletedTreatmentNausea / Neoplasms, Breast / Vomiting1
Not AvailableCompletedTreatmentNeoplasms, Pancreatic1
Not AvailableCompletedTreatmentOedema / Pain NOS / Trismus2
Not AvailableCompletedTreatmentPain NOS1
Not AvailableCompletedTreatmentPain, Acute / Postoperative pain / Upper Extremity Injury1
Not AvailableCompletedTreatmentParathyroid Diseases / Thyroid Diseases1
Not AvailableCompletedTreatmentPatients Undergoing Ankle Surgery1
Not AvailableCompletedTreatmentPituitary Adenomas / Pituitary Diseases1
Not AvailableCompletedTreatmentPneumonia1
Not AvailableCompletedTreatmentPost Surgical Pain1
Not AvailableCompletedTreatmentPost-Operative Nausea and Vomiting (PONV)2
Not AvailableCompletedTreatmentPost-Operative Nausea and Vomiting (PONV) / Postoperative pain / Tiredness1
Not AvailableCompletedTreatmentPost-operative Hemorrhage1
Not AvailableCompletedTreatmentPostoperative pain1
Not AvailableCompletedTreatmentPosttraumatic Stress Disorders1
Not AvailableCompletedTreatmentPregnancy1
Not AvailableCompletedTreatmentPreterm Premature Rupture of Membranes1
Not AvailableCompletedTreatmentProstate Ca1
Not AvailableCompletedTreatmentRupture of Anterior Cruciate Ligament / Tear of Anterior Cruciate Ligament1
Not AvailableCompletedTreatmentT-cell Childhood Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
Not AvailableCompletedTreatmentViral Bronchiolitis1
Not AvailableEnrolling by InvitationOtherAnalgesia / Brachial Plexus Block / Motor Activities1
Not AvailableEnrolling by InvitationTreatmentGeneral Surgery / Molar, Third1
Not AvailableNot Yet RecruitingNot AvailableRelapsed and/or Refractory Multiple Myeloma1
Not AvailableNot Yet RecruitingDiagnosticDiabetic Foot1
Not AvailableNot Yet RecruitingPreventionPostoperative pain / Ureter Stone1
Not AvailableNot Yet RecruitingSupportive CareCesarean Section Complications / Post-Cesarean Pain1
Not AvailableNot Yet RecruitingTreatmentBack Pain Lower Back1
Not AvailableNot Yet RecruitingTreatmentBell's Palsy1
Not AvailableNot Yet RecruitingTreatmentCapsular Contracture, Implant1
Not AvailableNot Yet RecruitingTreatmentCataracts / Diabetic Macular Edema (DME)1
Not AvailableNot Yet RecruitingTreatmentCataracts / Sleep1
Not AvailableNot Yet RecruitingTreatmentChemotherapy-Induced Nausea and Vomiting (CINV)1
Not AvailableNot Yet RecruitingTreatmentDry Eye Syndrome (DES)1
Not AvailableNot Yet RecruitingTreatmentInfertility, Female1
Not AvailableNot Yet RecruitingTreatmentOphthalmology1
Not AvailableNot Yet RecruitingTreatmentPost Operative Pain1
Not AvailableNot Yet RecruitingTreatmentPostoperative pain1
Not AvailableNot Yet RecruitingTreatmentSpinal Anesthetics Causing Adverse Effects in Therapeutic Use1
Not AvailableRecruitingNot AvailableAcute Lymphoblastic Leukaemias (ALL)1
Not AvailableRecruitingNot AvailableMultiple Myeloma (MM)2
Not AvailableRecruitingNot AvailableDiffuse posterior uveitis1
Not AvailableRecruitingBasic ScienceBMI >30 kg/m2 / Hyperandrogenemia / Polycystic Ovaries Syndrome1
Not AvailableRecruitingBasic ScienceBMI >30 kg/m2 / Hyperandrogenism / Polycystic Ovaries Syndrome1
Not AvailableRecruitingBasic ScienceFibrosis of the Retina / Macular Edema (ME)1
Not AvailableRecruitingBasic ScienceKnee Arthroscopic Surgery / Surgery of Knee Arthroscopy1
Not AvailableRecruitingDiagnosticRecurrent Non-Small Cell Lung Carcinoma / Stage IIIA Non-Small Cell Lung Cancer / Stage IIIb Non-small Cell Lung Cancer / Stage IV Non-Small Cell Lung Cancer1
Not AvailableRecruitingOtherUpper Extremity Injury1
Not AvailableRecruitingPreventionBilateral Superficial Cervical Block1
Not AvailableRecruitingPreventionCesarean Section1
Not AvailableRecruitingPreventionChemotherapy-Induced Nausea and Vomiting (CINV)1
Not AvailableRecruitingPreventionCytokines / Dexamethasone / Pain, Chronic / Thoracic Surgery1
Not AvailableRecruitingPreventionNeonatal Respiratory Distress Syndrome1
Not AvailableRecruitingPreventionPost-Operative Nausea and Vomiting (PONV)1
Not AvailableRecruitingPreventionPostoperative pain1
Not AvailableRecruitingSupportive CareColonic Neoplasms1
Not AvailableRecruitingSupportive CareInguinal Hernias / Postoperative pain1
Not AvailableRecruitingSupportive CarePostoperative pain / Undescended Testis1
Not AvailableRecruitingTreatment1Q21 Amplification / Complex Karyotype / Extramedullary Plasmacytoma / Leukemia, Plasma Cell / Loss of Chromosome 17p / Multiple Myeloma (MM) / T(14;16) / T(14;20) / T(4;14)1
Not AvailableRecruitingTreatmentAcute Lymphoblastic Leukemia Ph Positive1
Not AvailableRecruitingTreatmentAdenocarcinoma, Prostate / Hormone-Resistant Prostate Cancer / Metastatic Hormone Refractory Prostate Cancer / Stage IV Prostate Cancer1
Not AvailableRecruitingTreatmentAge-related Cataract1
Not AvailableRecruitingTreatmentAllergies / Urticarias1
Not AvailableRecruitingTreatmentAmyloidosis; Systemic1
Not AvailableRecruitingTreatmentAortic Root Dilatation / Aortic Valve Disorder / Coronary Artery Disease / Diseases of Mitral Valve / Surgery, Cardiac / Tricuspid valve disease1
Not AvailableRecruitingTreatmentCataracts1
Not AvailableRecruitingTreatmentChildhood Acute Lymphoblastic Leukemia1
Not AvailableRecruitingTreatmentChronic Lung Diseases / Lung Cancers1
Not AvailableRecruitingTreatmentDental Research / Pharmaceutical Preparations, Dental1
Not AvailableRecruitingTreatmentEpiretinal Membrane / Macular Edema (ME)1
Not AvailableRecruitingTreatmentExtranodal NK-T-Cell Lymphoma, Nasal Type1
Not AvailableRecruitingTreatmentGlaucoma, Angle-Closure / Glaucoma, Closed-Angle / Glaucoma, Narrow-Angle1
Not AvailableRecruitingTreatmentImpacted Third Molar Tooth1
Not AvailableRecruitingTreatmentKnee Arthropathy1
Not AvailableRecruitingTreatmentLigament Injury / Nerve Entrapment / Osteoarthritis (OA) / Rheumatoid Arthritis1
Not AvailableRecruitingTreatmentMyopia / Refractive Errors1
Not AvailableRecruitingTreatmentPain NOS1
Not AvailableRecruitingTreatmentPelvic Organ Prolapse (POP) / Prolapses, Vaginal Vault / Quality of Life1
Not AvailableRecruitingTreatmentPost Operative Pain1
Not AvailableRecruitingTreatmentPostoperative pain1
Not AvailableRecruitingTreatmentSciatic Radiculopathy / Sciatica / Sciatica Due to Intervertebral Disc Disorder1
Not AvailableRecruitingTreatmentStiffness Following Total Knee Arthroplasty1
Not AvailableRecruitingTreatmentCaudal epidural block therapy1
Not AvailableTerminatedNot AvailableNon-Infectious Uveitis1
Not AvailableTerminatedNot AvailableBacterial blepharitis1
Not AvailableTerminatedOtherLumbar Back Pain / Lumbar Radiculitis / Lumbar Spine Disc Herniation1
Not AvailableTerminatedPreventionAsymptomatic Gallstones Without Cholecystitis / Gallbladder Polyps1
Not AvailableTerminatedSupportive CareMalignant Digestive System Neoplasm / Nausea and vomiting1
Not AvailableTerminatedSupportive CareMalignant Ovarian Mixed Epithelial Tumor / Nausea and vomiting / Ovarian Brenner Tumor / Ovarian Clear Cell Cystadenocarcinoma / Ovarian Endometrioid Adenocarcinoma / Ovarian Mucinous Cystadenocarcinoma / Ovarian Seromucinous Carcinoma / Ovarian Serous Cystadenocarcinoma / Stage II Ovarian Cancer / Stage IIA Fallopian Tube Cancer / Stage IIA Ovarian Cancer / Stage IIB Fallopian Tube Cancer / Stage IIB Ovarian Cancer / Stage IIC Fallopian Tube Cancer / Stage IIC Ovarian Cancer / Stage IIIA Fallopian Tube Cancer / Stage IIIA Ovarian Cancer / Stage IIIA Primary Peritoneal Cancer / Stage IIIB Fallopian Tube Cancer / Stage IIIB Ovarian Cancer / Stage IIIB Primary Peritoneal Cancer / Stage IIIC Fallopian Tube Cancer / Stage IIIC Ovarian Cancer / Stage IIIC Primary Peritoneal Cancer / Stage IV Fallopian Tube Cancer / Stage IV Ovarian Cancer / Stage IV Primary Peritoneal Cancer / Undifferentiated Ovarian Carcinoma1
Not AvailableTerminatedSupportive CarePain NOS1
Not AvailableTerminatedTreatmentCellulitis1
Not AvailableTerminatedTreatmentDiabetic Macular Edema (DME)1
Not AvailableTerminatedTreatmentEclampsia1
Not AvailableTerminatedTreatmentEpiretinal Membrane / Macular Edema (ME)1
Not AvailableTerminatedTreatmentEpiretinal Membrane / Macular Edema (ME) / Vitrectomy therapy1
Not AvailableTerminatedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Non-Hodgkin's Lymphoma (NHL)1
Not AvailableTerminatedTreatmentInflammatory Bowel Diseases (IBD)1
Not AvailableTerminatedTreatmentInflammatory Reaction / Perioperative Morbidity1
Not AvailableTerminatedTreatmentLaparoscopic Colorectal Resection1
Not AvailableTerminatedTreatmentLymphohistiocytosis, Hemophagocytic1
Not AvailableTerminatedTreatmentMacular Edema (ME) / Retinal Vein Occlusions(RVO)1
Not AvailableTerminatedTreatmentTotal Knee Arthroplasty (TKA)1
Not AvailableUnknown StatusNot AvailablePlasma Cell Myeloma1
Not AvailableUnknown StatusPreventionNausea / Vomiting1
Not AvailableUnknown StatusPreventionPharyngitis1
Not AvailableUnknown StatusPreventionPonv / Pregnancy1
Not AvailableUnknown StatusPreventionRespiratory Sounds1
Not AvailableUnknown StatusSupportive CareBrain and Central Nervous System Tumors / Cognitive/Functional Effects / Radiation Toxicity1
Not AvailableUnknown StatusTreatmentAnalgesia1
Not AvailableUnknown StatusTreatmentEarly Gastric Cancer or Gastric Adenoma1
Not AvailableUnknown StatusTreatmentFull-frequency Sudden Hearing Loss1
Not AvailableUnknown StatusTreatmentGlaucoma1
Not AvailableUnknown StatusTreatmentHepatic Failure / Viral Hepatitis B1
Not AvailableUnknown StatusTreatmentLeukemias1
Not AvailableUnknown StatusTreatmentOedema / Pain NOS / Trismus1
Not AvailableUnknown StatusTreatmentPost Tonsillectomy Pain1
Not AvailableUnknown StatusTreatmentRadicular Pain1
Not AvailableUnknown StatusTreatmentRadiculopathy, Cervical1
Not AvailableUnknown StatusTreatmentRetinal Vein Occlusions(RVO)1
Not AvailableUnknown StatusTreatmentStridor1
Not AvailableWithdrawnNot AvailableType 1 Insulin-Dependent Diabetes Mellitus1
Not AvailableWithdrawnBasic ScienceCoronary Artery Bypass Graft Surgery Patients / Coronary Artery Stenosis1
Not AvailableWithdrawnPreventionRespiratory Complications / Swallowing Disorders1
Not AvailableWithdrawnSupportive CareNeoplasms, Malignant / Ototoxicity1
Not AvailableWithdrawnTreatmentAngioid Streaks / Central Serous Chorioretinopathy (CSC) / Multifocal Choroiditis / Myopia / Ocular Histoplasmosis Syndrome / Punctate Inner Choroidopathy (PIC) / Subfoveal Choroidal Neovascularization / Trauma, or Hereditary Eye Diseases1
Not AvailableWithdrawnTreatmentDescemet's Stripping Endothelial Keratoplasty / Endothelial Dystrophy / Posterior Lamellar Keratoplasty / Secondary Bullous Keratopathy1
Not AvailableWithdrawnTreatmentGlioblastoma Multiforme (GBM)1
Not AvailableWithdrawnTreatmentInsulin-dependent Diabetics / Shoulder Injury1
Not AvailableWithdrawnTreatmentPain, Sciatic Block1
Not AvailableWithdrawnTreatmentProstate Cancer1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
  • Advanced Pharmaceutical Services Inc.
  • Akorn Inc.
  • Alcon Laboratories
  • Allergan Inc.
  • Amend
  • American Regent
  • Amerisource Health Services Corp.
  • Apotheca Inc.
  • APP Pharmaceuticals
  • A-S Medication Solutions LLC
  • Atlantic Biologicals Corporation
  • Bausch & Lomb Inc.
  • Baxter International Inc.
  • Bimeda Inc.
  • Blansett Pharmacal Co. Inc.
  • Bryant Ranch Prepack
  • C.O. Truxton Inc.
  • Cardinal Health
  • Carlisle Laboratories Inc.
  • Clint Pharmaceutical Inc.
  • Consolidated Midland Corp.
  • Darby Dental Supply Co. Inc.
  • Direct Dispensing Inc.
  • Dispensing Solutions
  • Diversified Healthcare Services Inc.
  • ECR Pharmaceuticals
  • Falcon Pharmaceuticals Ltd.
  • General Injectables and Vaccines Inc.
  • Generics Puerto Rico Inc.
  • Keene Pharmaceuticals Inc.
  • Lake Erie Medical and Surgical Supply
  • Luitpold Pharmaceuticals Inc.
  • Major Pharmaceuticals
  • Martica Enterprises Inc.
  • Martin Surgical Supply
  • Medisca Inc.
  • Merck & Co.
  • Merit Pharmaceuticals
  • Murfreesboro Pharmaceutical Nursing Supply
  • MWI Veterinary Supply Co.
  • National Pharmaceuticals
  • Neuman Distributors Inc.
  • Nord Ost Corp.
  • Nucare Pharmaceuticals Inc.
  • Ocusoft
  • Paddock Labs
  • Par Pharmaceuticals
  • PCA LLC
  • PD-Rx Pharmaceuticals Inc.
  • Pharmedix
  • Physicians Total Care Inc.
  • Preferred Pharmaceuticals Inc.
  • Prescript Pharmaceuticals
  • Primedics Laboratories
  • Qualitest
  • Raz Co. Inc.
  • Rebel Distributors Corp.
  • Redpharm Drug
  • Remedy Repack
  • Resource Optimization and Innovation LLC
  • Robar Inc.
  • Roxane Labs
  • San Jose Surgical Supply Inc.
  • Sandhills Packaging Inc.
  • Southwood Pharmaceuticals
  • St Mary's Medical Park Pharmacy
  • Stat Rx Usa
  • Strides Arcolab Limited
  • Teva Pharmaceutical Industries Ltd.
  • Veratex Corp.
  • Wa Butler Co.
  • Wockhardt Ltd.
Dosage forms
FormRouteStrength
OintmentTopical
ElixirOral0.5 mg/5mL
SuspensionAuricular (otic)
Suspension / dropsAuricular (otic)
LiquidDental
LiquidAuricular (otic); Ophthalmic
Injection, solutionOphthalmic
Injection, solutionIntraocular
SolutionAuricular (otic); Ophthalmic0.1 %
SolutionOral0.5 mg/5mL
TabletOral0.5 mg/1
TabletOral0.75 mg/1
TabletOral1 mg/1
TabletOral1.5 mg/1
TabletOral2 mg/1
TabletOral4 mg/1
TabletOral6 mg/1
Solution, concentrateOral1 mg/1mL
LiquidIntramuscular; Intrasynovial; Intravenous
InjectionIntra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue4 mg/1mL
InjectionIntramuscular10 mg/1mL
InjectionIntramuscular; Intravenous10 mg/1mL
InjectionIntramuscular; Intravenous100 mg/10mL
Injection, emulsionIntramuscular; Intravenous10 mg/1mL
Injection, solutionIntra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue4 mg/1mL
Injection, solutionIntramuscular4 mg/1mL
Injection, solutionIntramuscular; Intravenous4 mg/1mL
Injection, solutionIntravenous4 mg/1mL
Injection, suspensionIntra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue4 mg/1mL
SolutionOphthalmic1 mg/1mL
Solution / dropsOphthalmic1 mg/1mL
SolutionTopical
SolutionIntramuscular; Intrasynovial; Intravenous
LiquidIntra-articular; Intramuscular; Intravenous
SolutionIntra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue
SolutionIntramuscular; Intravenous
LiquidIntra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue
KitTopical
InsertOphthalmic0.4 mg/1
Injection, suspensionIntraocular517 ug/0.005mL
Injection, solutionIntramuscular; Intravenous10 mg/1mL
Implant
Injection, solutionIntra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue10 mg/1mL
KitPerineural
OintmentOphthalmic0.1 %
OintmentOphthalmic0.5 mg/1g
SuspensionOphthalmic0.1 %
SuspensionOphthalmic1 mg/1mL
Solution / dropsOphthalmic
OintmentOphthalmic
LiquidAuricular (otic); Ophthalmic
TabletOral40 mg
SuspensionOphthalmic
Suspension / dropsOphthalmic
LiquidOphthalmic; Topical
SolutionAuricular (otic); Ophthalmic
ImplantIntravitreal0.7 mg/1
ImplantIntravitreal0.7 mg
ImplantIntravitreal700 mcg
ElixirOral
LiquidOral
TabletOral
LiquidIntramuscular; Intravenous
SolutionIntra-articular; Intramuscular; Intravenous
Solution / dropsAuricular (otic); Ophthalmic
KitIntramuscular; Intravenous
SolutionAuricular (otic); Ophthalmic
Solution / dropsAuricular (otic); Ophthalmic
Solution / dropsTopical
OintmentAuricular (otic); Ophthalmic
Prices
Unit descriptionCostUnit
Ozurdex 0.7 mg implant1554.0USD implant
Maxidex 0.1% Suspension 15ml Bottle97.96USD bottle
Maxitrol 0.1-5-10000 Ointment 3.5 gm Tube87.3USD tube
Maxitrol 5-10000-0.1 Suspension 5ml Bottle75.88USD bottle
Maxidex 0.1% Suspension 5ml Bottle53.57USD bottle
Dexamethasone Sodium Phosphate 4 mg/ml Solution (1 Box = 25x1ml Vials)41.99USD box
Dexamethasone micronized powd41.31USD g
Dexamethasone powder21.27USD g
Dexamethasone Sodium Phosphate 0.1% Solution 5ml Bottle19.99USD bottle
Dexamethasone acetate powd15.12USD g
Dexamethasone sod ph powder14.24USD g
Dexamethasone Sodium Phosphate 4 mg/ml Solution 5ml Vial13.99USD vial
Dexamethasone Sodium Phosphate 10 mg/ml4.78USD ml
Dexamethasone Sodium Phosphate 4 mg/ml 1 Vial = 5ml4.0USD ml
Dexamethasone 0.1% eye drop3.43USD ml
Dexasol 0.1% eye drops3.38USD ml
Maxidex 0.1 % Ointment2.69USD g
Dexamethasone 10 mg/ml vial2.56USD ml
Maxidex 0.1% eye drops2.36USD ml
Dexamethasone Sodium Phosphate 4 mg/ml1.77USD ml
Maxidex 0.1 % Suspension1.73USD ml
Sandoz Dexamethasone Sod. Phosphate 0.1 % Solution1.38USD ml
Pms-Dexamethasone Sodium Phosp 10 mg/ml1.34USD ml
Dexamethasone 4 mg/ml vial1.04USD ml
Dexamethasone 6 mg tablet1.01USD tablet
Dexasone 4 mg Tablet0.86USD tablet
Apo-Dexamethasone 4 mg Tablet0.8USD tablet
Pms-Dexamethasone 4 mg Tablet0.8USD tablet
Ratio-Dexamethasone 4 mg Tablet0.8USD tablet
Dexamethasone 2 mg tablet0.68USD tablet
Dexamethasone 1 mg/1 ml soln0.65USD ml
Dexamethasone 4 mg tablet0.6USD tablet
Dexamethasone 1 mg tablet0.49USD tablet
Pms-Dexamethasone 0.75 mg Tablet0.47USD tablet
Pms-Dexamethasone 2 mg Tablet0.43USD tablet
Dexamethasone 0.5 mg/5ml Elixir0.4USD ml
Dexamethasone 0.75 mg tablet0.38USD tablet
Dexamethasone 1.5 mg tablet0.35USD tablet
Dexamethasone 0.5 mg tablet0.31USD tablet
Apo-Dexamethasone 0.5 mg Tablet0.21USD tablet
Pms-Dexamethasone 0.5 mg Tablet0.2USD tablet
Ratio-Dexamethasone 0.5 mg Tablet0.18USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US8846650No2014-09-302025-06-04Us
US9149486No2015-10-062022-09-13Us
US6359016No2002-03-192020-08-10Us
US6284804No2001-09-042020-08-10Us
US6726918No2004-04-272020-10-20Us
US6899717No2005-05-312023-11-01Us
US8034366No2011-10-112023-01-09Us
US8506987No2013-08-132023-01-09Us
US9012437No2015-04-212020-10-20Us
US8043628No2011-10-252020-10-20Us
US8088407No2012-01-032020-10-20Us
US9283178No2016-03-152020-10-20Us
US9192511No2015-11-242023-01-09Us
US8063031No2011-11-222020-10-20Us
US7033605No2006-04-252020-10-20Us
US7767223No2010-08-032021-11-28Us
US8034370No2011-10-112023-01-09Us
US7795316No2010-09-142028-08-03Us
US8101582No2012-01-242027-12-19Us
US8450287No2013-05-282027-12-19Us
US9345714No2016-05-242022-09-13Us
US9402805No2016-08-022022-09-13Us
US9592242No2017-03-142020-10-20Us
US9775849No2017-10-032020-10-20Us
US6960346No2005-11-012023-07-03Us
US7560120No2009-07-142022-09-05Us
US10028965No2018-07-242034-05-23Us
US10022502No2018-07-172020-09-12Us
US10076526No2018-09-182023-01-09Us
US8563027No2013-10-222030-02-12Us
US8409606No2013-04-022030-05-14Us
US10159683No2018-12-252034-05-23Us
US9254267No2016-02-092024-09-11Us
Additional Data Available
  • Filed On
    Filed On

    The date on which a patent was filed with the relevant government.

    Learn more

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)170-229Fried, J.; US. Patent 2,852.51 1; September 16, 1958; assigned to Olin Mathieson Chemical Corporation. Muller, G., Bardoneschi, R. and Jolly, J.; U.S. Patent 3,007,923; November 7, 1961; assigned to Les Laboratories Francais de Chimiotherapie, France.
water solubility89 mg/L (at 25 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP1.83HANSCH,C ET AL. (1995)
logS-3.64ADME Research, USCD
Caco2 permeability-4.75ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility0.0505 mg/mLALOGPS
logP1.93ALOGPS
logP1.68ChemAxon
logS-3.9ALOGPS
pKa (Strongest Acidic)12.42ChemAxon
pKa (Strongest Basic)-3.3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area94.83 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity102.49 m3·mol-1ChemAxon
Polarizability40.71 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.992
Blood Brain Barrier+0.9781
Caco-2 permeable+0.8304
P-glycoprotein substrateSubstrate0.7862
P-glycoprotein inhibitor INon-inhibitor0.8112
P-glycoprotein inhibitor IINon-inhibitor0.8134
Renal organic cation transporterNon-inhibitor0.7971
CYP450 2C9 substrateNon-substrate0.8733
CYP450 2D6 substrateNon-substrate0.9115
CYP450 3A4 substrateSubstrate0.7315
CYP450 1A2 substrateNon-inhibitor0.938
CYP450 2C9 inhibitorNon-inhibitor0.9106
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9247
CYP450 3A4 inhibitorNon-inhibitor0.8308
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9169
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.9399
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.1482 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9558
hERG inhibition (predictor II)Inhibitor0.5091
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-01ot-0904000000-dbbc479b104fbe981ce7
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-0002-0903000000-c84b561c97b1277fed56
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-0002-0903000000-b498846e21073040b905
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-0002-0900000000-b04e175289861dc518f1
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-0002-0900000000-b04e175289861dc518f1
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-01ot-0904000000-dbbc479b104fbe981ce7
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-0002-0903000000-c84b561c97b1277fed56
LC-MS/MS Spectrum - LC-ESI-ITFT , negativeLC-MS/MSsplash10-0002-0903000000-b498846e21073040b905
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-006w-0719000000-d4feef3f83ca022aa94d
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0002-0913000000-3c8e5afb526637f1e822
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0002-0910000000-57f268bed9b190ee6066
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0002-0900000000-cfdda545a27ec16c8b76
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0002-0900000000-c70817ad99741f01b675
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-00di-0009000000-ecbabc9fe90444b14afe
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-05fr-0019000000-4161bdd8f3deed25b9bc
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-002r-0594000000-bf4495b7906d53ad019d
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-00ds-0980000000-c4e88ec70fa28252f6f7
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-05fs-0930000000-8022e38d862953c2551b
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-05fs-1920000000-6f1a7ac153a363c2aa73
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-00tf-1910000000-e34981c957b125a39447
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-05fr-0019000000-285cd2de8c812f1c5e55
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-002r-0593000000-bd52212afb3af2380901
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-00ds-0980000000-ff265e4738c79efad9e3
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-00dj-0940000000-818b114d12290dc23743
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-05fs-1930000000-9e4283fb9c2780729f55
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-05dm-1920000000-0f41e220b5d3d1abe699
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-00di-0009000000-cf986616b1138d5569c7
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-00dl-0009000000-431895662c53cadb563c
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0a4r-0498000000-233b2490f89112ad539e
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-000j-0791000000-c83a21019f43596e6804
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-00dj-0970000000-36eebd63d78f040ae67f
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-00dj-0940000000-730013951a30cf080ad4
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0a4r-0696000000-1df7921eb1369fef69c4
MS/MS Spectrum - , positiveLC-MS/MSsplash10-00dj-3960000000-e9ee044790c0655981b1

Taxonomy

Description
This compound belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone.
Kingdom
Organic compounds
Super Class
Lipids and lipid-like molecules
Class
Steroids and steroid derivatives
Sub Class
Hydroxysteroids
Direct Parent
21-hydroxysteroids
Alternative Parents
Gluco/mineralocorticoids, progestogins and derivatives / 20-oxosteroids / 11-beta-hydroxysteroids / 17-hydroxysteroids / 3-oxo delta-1,4-steroids / Halogenated steroids / Delta-1,4-steroids / Tertiary alcohols / Alpha-hydroxy ketones / Secondary alcohols
show 8 more
Substituents
Progestogin-skeleton / 21-hydroxysteroid / Pregnane-skeleton / 20-oxosteroid / 3-oxo-delta-1,4-steroid / 3-oxosteroid / 17-hydroxysteroid / 11-hydroxysteroid / 11-beta-hydroxysteroid / 9-halo-steroid
show 23 more
Molecular Framework
Aliphatic homopolycyclic compounds
External Descriptors
11beta-hydroxy steroid, 17alpha-hydroxy steroid, glucocorticoid, 20-oxo steroid, fluorinated steroid, 3-oxo-Delta(1),Delta(4)-steroid, 21-hydroxy steroid (CHEBI:41879) / Pregnane and derivatives [Fig] (C15643)

Targets

Details
1. Glucocorticoid receptor
Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Agonist
General Function
Zinc ion binding
Specific Function
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modula...
Gene Name
NR3C1
Uniprot ID
P04150
Uniprot Name
Glucocorticoid receptor
Molecular Weight
85658.57 Da
References
  1. Warne JP, John CD, Christian HC, Morris JF, Flower RJ, Sugden D, Solito E, Gillies GE, Buckingham JC: Gene deletion reveals roles for annexin A1 in the regulation of lipolysis and IL-6 release in epididymal adipose tissue. Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1264-73. Epub 2006 Jul 11. [PubMed:16835395]
  2. Grossman R, Yehuda R, Golier J, McEwen B, Harvey P, Maria NS: Cognitive effects of intravenous hydrocortisone in subjects with PTSD and healthy control subjects. Ann N Y Acad Sci. 2006 Jul;1071:410-21. [PubMed:16891588]
  3. Funato H, Kobayashi A, Watanabe Y: Differential effects of antidepressants on dexamethasone-induced nuclear translocation and expression of glucocorticoid receptor. Brain Res. 2006 Oct 30;1117(1):125-34. Epub 2006 Sep 7. [PubMed:16956592]
  4. Vaitkuviene A, Ulinskaite A, Meskys R, Duburs G, Klusa V, Liutkevicius E: Study of the interaction of 1,4-dihydropyridine derivatives with glucocorticoid hormone receptors from the rat liver. Pharmacol Rep. 2006 Jul-Aug;58(4):551-8. [PubMed:16963802]
  5. Wang D, Zhang H, Lang F, Yun CC: Acute activation of NHE3 by dexamethasone correlates with activation of SGK1 and requires a functional glucocorticoid receptor. Am J Physiol Cell Physiol. 2007 Jan;292(1):C396-404. Epub 2006 Sep 13. [PubMed:16971495]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Stimulator
General Function
Transcription factor binding
Specific Function
Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional act...
Gene Name
NR0B1
Uniprot ID
P51843
Uniprot Name
Nuclear receptor subfamily 0 group B member 1
Molecular Weight
51717.185 Da
References
  1. Gummow BM, Scheys JO, Cancelli VR, Hammer GD: Reciprocal regulation of a glucocorticoid receptor-steroidogenic factor-1 transcription complex on the Dax-1 promoter by glucocorticoids and adrenocorticotropic hormone in the adrenal cortex. Mol Endocrinol. 2006 Nov;20(11):2711-23. Epub 2006 Jul 20. [PubMed:16857744]
  2. Yu CC, Li PH: In vivo inhibition of steroidogenic acute regulatory protein expression by dexamethasone parallels induction of the negative transcription factor DAX-1. Endocrine. 2006 Dec;30(3):313-23. [PubMed:17526944]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Agonist
General Function
Structural molecule activity
Specific Function
Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Play...
Gene Name
ANXA1
Uniprot ID
P04083
Uniprot Name
Annexin A1
Molecular Weight
38713.855 Da
References
  1. Morand EF, Hall P, Hutchinson P, Yang YH: Regulation of annexin I in rheumatoid synovial cells by glucocorticoids and interleukin-1. Mediators Inflamm. 2006;2006(2):73835. [PubMed:16883066]
  2. John CD, Theogaraj E, Christian HC, Morris JF, Smith SF, Buckingham JC: Time-specific effects of perinatal glucocorticoid treatment on anterior pituitary morphology, annexin 1 expression and adrenocorticotrophic hormone secretion in the adult female rat. J Neuroendocrinol. 2006 Dec;18(12):949-59. [PubMed:17076770]
  3. Davies E, Omer S, Buckingham JC, Morris JF, Christian HC: Expression and externalization of annexin 1 in the adrenal gland: structure and function of the adrenal gland in annexin 1-null mutant mice. Endocrinology. 2007 Mar;148(3):1030-8. Epub 2006 Dec 7. [PubMed:17158208]
  4. Wang C, Wang J, Guo HF, Liu RY: Involvement of annexin I in the dexamethasone-mediated upregulation of A549 cells phagocytosis of apoptotic eosinophils. Immunol Lett. 2007 Aug 15;111(2):103-10. Epub 2007 Jul 2. [PubMed:17644190]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Negative modulator
General Function
Tetrahydrobiopterin binding
Specific Function
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity ...
Gene Name
NOS2
Uniprot ID
P35228
Uniprot Name
Nitric oxide synthase, inducible
Molecular Weight
131116.3 Da
References
  1. Soderberg M, Raffalli-Mathieu F, Lang MA: Regulation of the murine inducible nitric oxide synthase gene by dexamethasone involves a heterogeneous nuclear ribonucleoprotein I (hnRNPI) dependent pathway. Mol Immunol. 2007 May;44(12):3204-10. Epub 2007 Mar 26. [PubMed:17379310]
  2. Huang H, Lavoie-Lamoureux A, Moran K, Lavoie JP: IL-4 stimulates the expression of CXCL-8, E-selectin, VEGF, and inducible nitric oxide synthase mRNA by equine pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2007 May;292(5):L1147-54. [PubMed:17494951]
  3. Nandi J, Saud B, Zinkievich JM, Palma DT, Levine RA: 5-aminosalicylic acid improves indomethacin-induced enteropathy by inhibiting iNOS transcription in rats. Dig Dis Sci. 2008 Jan;53(1):123-32. Epub 2007 May 15. [PubMed:17503181]
  4. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Zinc ion binding
Specific Function
Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism an...
Gene Name
NR1I2
Uniprot ID
O75469
Uniprot Name
Nuclear receptor subfamily 1 group I member 2
Molecular Weight
49761.245 Da
References
  1. Kretschmer XC, Baldwin WS: CAR and PXR: xenosensors of endocrine disrupters? Chem Biol Interact. 2005 Aug 15;155(3):111-28. [PubMed:16054614]

Enzymes

Details
1. Cytochrome P450 3A4
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
Inducer
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Ekins S, Bravi G, Wikel JH, Wrighton SA: Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates. J Pharmacol Exp Ther. 1999 Oct;291(1):424-33. [PubMed:10490933]
  2. Lampen A, Christians U, Guengerich FP, Watkins PB, Kolars JC, Bader A, Gonschior AK, Dralle H, Hackbarth I, Sewing KF: Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability. Drug Metab Dispos. 1995 Dec;23(12):1315-24. [PubMed:8689938]
  3. Christians U, Schmidt G, Bader A, Lampen A, Schottmann R, Linck A, Sewing KF: Identification of drugs inhibiting the in vitro metabolism of tacrolimus by human liver microsomes. Br J Clin Pharmacol. 1996 Mar;41(3):187-90. [PubMed:8866917]
  4. Miranda SR, Meyer SA: Cytotoxicity of chloroacetanilide herbicide alachlor in HepG2 cells independent of CYP3A4 and CYP3A7. Food Chem Toxicol. 2007 May;45(5):871-7. doi: 10.1016/j.fct.2006.11.011. Epub 2006 Nov 26. [PubMed:17207564]
  5. Yamaguchi Y, Kirita S, Baba T, Aoyama J, Touchi A, Tukey RH, Guengerich FP, Matsubara T: Identification of rat and human cytochrome P450 forms involved in the metabolism of the thromboxane A2 receptor antagonist (+)-S-145. Drug Metab Dispos. 1997 Jan;25(1):75-80. [PubMed:9010633]
  6. Gomez-Lechon MJ, Donato T, Jover R, Rodriguez C, Ponsoda X, Glaise D, Castell JV, Guguen-Guillouzo C: Expression and induction of a large set of drug-metabolizing enzymes by the highly differentiated human hepatoma cell line BC2. Eur J Biochem. 2001 Mar;268(5):1448-59. [PubMed:11231298]
  7. Berson A, Wolf C, Chachaty C, Fisch C, Fau D, Eugene D, Loeper J, Gauthier JC, Beaune P, Pompon D, et al.: Metabolic activation of the nitroaromatic antiandrogen flutamide by rat and human cytochromes P-450, including forms belonging to the 3A and 1A subfamilies. J Pharmacol Exp Ther. 1993 Apr;265(1):366-72. [PubMed:8386241]
  8. McCune JS, Hawke RL, LeCluyse EL, Gillenwater HH, Hamilton G, Ritchie J, Lindley C: In vivo and in vitro induction of human cytochrome P4503A4 by dexamethasone. Clin Pharmacol Ther. 2000 Oct;68(4):356-66. doi: 10.1067/mcp.2000.110215. [PubMed:11061575]
  9. Flockhart Table of Drug Interactions [Link]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inducer
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A5
Uniprot ID
P20815
Uniprot Name
Cytochrome P450 3A5
Molecular Weight
57108.065 Da
References
  1. Hukkanen J, Lassila A, Paivarinta K, Valanne S, Sarpo S, Hakkola J, Pelkonen O, Raunio H: Induction and regulation of xenobiotic-metabolizing cytochrome P450s in the human A549 lung adenocarcinoma cell line. Am J Respir Cell Mol Biol. 2000 Mar;22(3):360-6. [PubMed:10696073]
  2. Hukkanen J, Vaisanen T, Lassila A, Piipari R, Anttila S, Pelkonen O, Raunio H, Hakkola J: Regulation of CYP3A5 by glucocorticoids and cigarette smoke in human lung-derived cells. J Pharmacol Exp Ther. 2003 Feb;304(2):745-52. [PubMed:12538830]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inducer
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A7
Uniprot ID
P24462
Uniprot Name
Cytochrome P450 3A7
Molecular Weight
57525.03 Da
References
  1. Miranda SR, Meyer SA: Cytotoxicity of chloroacetanilide herbicide alachlor in HepG2 cells independent of CYP3A4 and CYP3A7. Food Chem Toxicol. 2007 May;45(5):871-7. doi: 10.1016/j.fct.2006.11.011. Epub 2006 Nov 26. [PubMed:17207564]
  2. Flockhart Table of Drug Interactions [Link]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid 17-alpha-monooxygenase activity
Specific Function
Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation ...
Gene Name
CYP17A1
Uniprot ID
P05093
Uniprot Name
Steroid 17-alpha-hydroxylase/17,20 lyase
Molecular Weight
57369.995 Da
References
  1. Trzeciak WH, LeHoux JG, Waterman MR, Simpson ER: Dexamethasone inhibits corticotropin-induced accumulation of CYP11A and CYP17 messenger RNAs in bovine adrenocortical cells. Mol Endocrinol. 1993 Feb;7(2):206-13. doi: 10.1210/mend.7.2.8385739. [PubMed:8385739]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inhibitor
Inducer
General Function
Vitamin d 24-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A1
Uniprot ID
P04798
Uniprot Name
Cytochrome P450 1A1
Molecular Weight
58164.815 Da
References
  1. Baron JM, Holler D, Schiffer R, Frankenberg S, Neis M, Merk HF, Jugert FK: Expression of multiple cytochrome p450 enzymes and multidrug resistance-associated transport proteins in human skin keratinocytes. J Invest Dermatol. 2001 Apr;116(4):541-8. doi: 10.1046/j.1523-1747.2001.01298.x. [PubMed:11286621]
  2. Monostory K, Kohalmy K, Prough RA, Kobori L, Vereczkey L: The effect of synthetic glucocorticoid, dexamethasone on CYP1A1 inducibility in adult rat and human hepatocytes. FEBS Lett. 2005 Jan 3;579(1):229-35. doi: 10.1016/j.febslet.2004.11.080. [PubMed:15620718]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inducer
General Function
Steroid hydroxylase activity
Specific Function
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Const...
Gene Name
CYP2A6
Uniprot ID
P11509
Uniprot Name
Cytochrome P450 2A6
Molecular Weight
56501.005 Da
References
  1. Onica T, Nichols K, Larin M, Ng L, Maslen A, Dvorak Z, Pascussi JM, Vilarem MJ, Maurel P, Kirby GM: Dexamethasone-mediated up-regulation of human CYP2A6 involves the glucocorticoid receptor and increased binding of hepatic nuclear factor 4 alpha to the proximal promoter. Mol Pharmacol. 2008 Feb;73(2):451-60. Epub 2007 Oct 31. [PubMed:17978169]
  2. Meunier V, Bourrie M, Julian B, Marti E, Guillou F, Berger Y, Fabre G: Expression and induction of CYP1A1/1A2, CYP2A6 and CYP3A4 in primary cultures of human hepatocytes: a 10-year follow-up. Xenobiotica. 2000 Jun;30(6):589-607. doi: 10.1080/004982500406426 . [PubMed:10923861]
  3. Waxman DJ, Chang TK: Spectrofluorometric analysis of CYP2A6-catalyzed coumarin 7-hydroxylation. Methods Mol Biol. 2006;320:91-6. doi: 10.1385/1-59259-998-2:91. [PubMed:16719377]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inducer
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2B6
Uniprot ID
P20813
Uniprot Name
Cytochrome P450 2B6
Molecular Weight
56277.81 Da
References
  1. Baron JM, Holler D, Schiffer R, Frankenberg S, Neis M, Merk HF, Jugert FK: Expression of multiple cytochrome p450 enzymes and multidrug resistance-associated transport proteins in human skin keratinocytes. J Invest Dermatol. 2001 Apr;116(4):541-8. doi: 10.1046/j.1523-1747.2001.01298.x. [PubMed:11286621]
  2. Wang H, Tompkins LM: CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme. Curr Drug Metab. 2008 Sep;9(7):598-610. [PubMed:18781911]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inducer
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and im...
Gene Name
CYP2C19
Uniprot ID
P33261
Uniprot Name
Cytochrome P450 2C19
Molecular Weight
55930.545 Da
References
  1. Raucy JL, Mueller L, Duan K, Allen SW, Strom S, Lasker JM: Expression and induction of CYP2C P450 enzymes in primary cultures of human hepatocytes. J Pharmacol Exp Ther. 2002 Aug;302(2):475-82. doi: 10.1124/jpet.102.033837. [PubMed:12130704]
  2. Scott SA, Sangkuhl K, Shuldiner AR, Hulot JS, Thorn CF, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for cytochrome P450, family 2, subfamily C, polypeptide 19. Pharmacogenet Genomics. 2012 Feb;22(2):159-65. doi: 10.1097/FPC.0b013e32834d4962. [PubMed:22027650]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inducer
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C8
Uniprot ID
P10632
Uniprot Name
Cytochrome P450 2C8
Molecular Weight
55824.275 Da
References
  1. Backman JT, Filppula AM, Niemi M, Neuvonen PJ: Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions. Pharmacol Rev. 2016 Jan;68(1):168-241. doi: 10.1124/pr.115.011411. [PubMed:26721703]
  2. Pascussi JM, Gerbal-Chaloin S, Fabre JM, Maurel P, Vilarem MJ: Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation. Mol Pharmacol. 2000 Dec;58(6):1441-50. doi: 10.1124/mol.58.6.1441. [PubMed:11093784]
  3. Gerbal-Chaloin S, Pascussi JM, Pichard-Garcia L, Daujat M, Waechter F, Fabre JM, Carrere N, Maurel P: Induction of CYP2C genes in human hepatocytes in primary culture. Drug Metab Dispos. 2001 Mar;29(3):242-51. [PubMed:11181490]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inducer
General Function
Steroid hydroxylase activity
Specific Function
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic ...
Gene Name
CYP2E1
Uniprot ID
P05181
Uniprot Name
Cytochrome P450 2E1
Molecular Weight
56848.42 Da
References
  1. Baron JM, Holler D, Schiffer R, Frankenberg S, Neis M, Merk HF, Jugert FK: Expression of multiple cytochrome p450 enzymes and multidrug resistance-associated transport proteins in human skin keratinocytes. J Invest Dermatol. 2001 Apr;116(4):541-8. doi: 10.1046/j.1523-1747.2001.01298.x. [PubMed:11286621]
  2. Sampol E, Mirrione A, Villard PH, Piccerelle P, Scoma H, Berbis P, Barra Y, Durand A, Lacarelle B: Evidence for a tissue-specific induction of cutaneous CYP2E1 by dexamethasone. Biochem Biophys Res Commun. 1997 Jun 27;235(3):557-61. doi: 10.1006/bbrc.1997.6829. [PubMed:9207195]
  3. Monostory K, Vereczkey L: Combined action of phenobarbital and dexamethasone on the activity of rat liver P450 system. Acta Pharm Hung. 1993 Sep;63(5):296-300. [PubMed:8249615]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inducer
General Function
Monooxygenase activity
Specific Function
Exhibits low testosterone 6-beta-hydroxylase activity.
Gene Name
CYP3A43
Uniprot ID
Q9HB55
Uniprot Name
Cytochrome P450 3A43
Molecular Weight
57669.21 Da
References
  1. Krusekopf S, Roots I, Kleeberg U: Differential drug-induced mRNA expression of human CYP3A4 compared to CYP3A5, CYP3A7 and CYP3A43. Eur J Pharmacol. 2003 Apr 11;466(1-2):7-12. doi: 10.1016/s0014-2999(03)01481-x. [PubMed:12679136]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inducer
General Function
Leukotriene-b4 20-monooxygenase activity
Specific Function
Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 2...
Gene Name
CYP4A11
Uniprot ID
Q02928
Uniprot Name
Cytochrome P450 4A11
Molecular Weight
59347.31 Da
References
  1. Cummings BS, Lasker JM, Lash LH: Expression of glutathione-dependent enzymes and cytochrome P450s in freshly isolated and primary cultures of proximal tubular cells from human kidney. J Pharmacol Exp Ther. 2000 May;293(2):677-85. [PubMed:10773044]
  2. Savas U, Hsu MH, Johnson EF: Differential regulation of human CYP4A genes by peroxisome proliferators and dexamethasone. Arch Biochem Biophys. 2003 Jan 1;409(1):212-20. doi: 10.1016/s0003-9861(02)00499-x. [PubMed:12464261]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid 11-beta-monooxygenase activity
Specific Function
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochro...
Gene Name
CYP11B1
Uniprot ID
P15538
Uniprot Name
Cytochrome P450 11B1, mitochondrial
Molecular Weight
57572.44 Da
References
  1. Fardella CE, Pinto M, Mosso L, Gomez-Sanchez C, Jalil J, Montero J: Genetic study of patients with dexamethasone-suppressible aldosteronism without the chimeric CYP11B1/CYP11B2 gene. J Clin Endocrinol Metab. 2001 Oct;86(10):4805-7. doi: 10.1210/jcem.86.10.7920. [PubMed:11600544]

Transporters

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inducer
General Function
Transporter activity
Specific Function
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
Gene Name
ABCB11
Uniprot ID
O95342
Uniprot Name
Bile salt export pump
Molecular Weight
146405.83 Da
References
  1. Fardel O, Payen L, Courtois A, Vernhet L, Lecureur V: Regulation of biliary drug efflux pump expression by hormones and xenobiotics. Toxicology. 2001 Oct 5;167(1):37-46. [PubMed:11557128]
Details
2. P-glycoprotein 1
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
Inducer
General Function
Xenobiotic-transporting atpase activity
Specific Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name
ABCB1
Uniprot ID
P08183
Uniprot Name
Multidrug resistance protein 1
Molecular Weight
141477.255 Da
References
  1. Geick A, Eichelbaum M, Burk O: Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem. 2001 May 4;276(18):14581-7. Epub 2001 Jan 31. [PubMed:11297522]
  2. Romiti N, Tramonti G, Chieli E: Influence of different chemicals on MDR-1 P-glycoprotein expression and activity in the HK-2 proximal tubular cell line. Toxicol Appl Pharmacol. 2002 Sep 1;183(2):83-91. [PubMed:12387747]
  3. Schuetz JD, Silverman JA, Thottassery JV, Furuya KN, Schuetz EG: Divergent regulation of the class II P-glycoprotein gene in primary cultures of hepatocytes versus H35 hepatoma by glucocorticoids. Cell Growth Differ. 1995 Oct;6(10):1321-32. [PubMed:8845310]
  4. Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. [PubMed:11602674]
  5. Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. [PubMed:12699389]
  6. Adachi Y, Suzuki H, Sugiyama Y: Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8. [PubMed:11785684]
  7. Yates CR, Chang C, Kearbey JD, Yasuda K, Schuetz EG, Miller DD, Dalton JT, Swaan PW: Structural determinants of P-glycoprotein-mediated transport of glucocorticoids. Pharm Res. 2003 Nov;20(11):1794-803. [PubMed:14661924]
  8. Schinkel AH, Wagenaar E, van Deemter L, Mol CA, Borst P: Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J Clin Invest. 1995 Oct;96(4):1698-705. [PubMed:7560060]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inducer
General Function
Organic anion transmembrane transporter activity
Specific Function
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Gene Name
ABCC2
Uniprot ID
Q92887
Uniprot Name
Canalicular multispecific organic anion transporter 1
Molecular Weight
174205.64 Da
References
  1. Demeule M, Jodoin J, Beaulieu E, Brossard M, Beliveau R: Dexamethasone modulation of multidrug transporters in normal tissues. FEBS Lett. 1999 Jan 15;442(2-3):208-14. [PubMed:9929003]
  2. Schrenk D, Baus PR, Ermel N, Klein C, Vorderstemann B, Kauffmann HM: Up-regulation of transporters of the MRP family by drugs and toxins. Toxicol Lett. 2001 Mar 31;120(1-3):51-7. [PubMed:11323161]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Xenobiotic-transporting atpase activity
Specific Function
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both fro...
Gene Name
ABCG2
Uniprot ID
Q9UNQ0
Uniprot Name
ATP-binding cassette sub-family G member 2
Molecular Weight
72313.47 Da
References
  1. Elahian F, Kalalinia F, Behravan J: Evaluation of indomethacin and dexamethasone effects on BCRP-mediated drug resistance in MCF-7 parental and resistant cell lines. Drug Chem Toxicol. 2010 Apr;33(2):113-9. doi: 10.3109/01480540903390000. [PubMed:20307139]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Sodium-independent organic anion transmembrane transporter activity
Specific Function
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibit...
Gene Name
SLCO1A2
Uniprot ID
P46721
Uniprot Name
Solute carrier organic anion transporter family member 1A2
Molecular Weight
74144.105 Da
References
  1. Kullak-Ublick GA, Fisch T, Oswald M, Hagenbuch B, Meier PJ, Beuers U, Paumgartner G: Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain. FEBS Lett. 1998 Mar 13;424(3):173-6. [PubMed:9539145]
  2. Bossuyt X, Muller M, Hagenbuch B, Meier PJ: Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver. J Pharmacol Exp Ther. 1996 Mar;276(3):891-6. [PubMed:8786566]

Drug created on June 13, 2005 07:24 / Updated on October 15, 2019 19:06