Identification
NameZinc
Accession NumberDB01593
TypeSmall Molecule
GroupsApproved
Description

A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with anemia, short stature, hypogonadism, impaired wound healing, and geophagia. It is known by the symbol Zn.

Structure
Thumb
Synonyms
30Zn
Cinc
Zinc
Zincum
Zink
Zn
Zn(ii)
Zn2+
External IDs Not Available
Product Ingredients
IngredientUNIICASInChI KeyDetails
Zinc acetateFM5526K07A 5970-45-6BEAZKUGSCHFXIQ-UHFFFAOYSA-LDetails
Zinc chloride86Q357L16B 7646-85-7JIAARYAFYJHUJI-UHFFFAOYSA-LDetails
Product Images
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
GalzinCapsule50 mg/1OralTeva Select Brands1997-01-28Not applicableUs57844 0208 52 nlmimage10 7c35be3d
GalzinCapsule25 mg/1OralTeva Select Brands1997-01-28Not applicableUs57844 0215 52 nlmimage10 ca366513
Male AdvantageCapsule5 mgOralBody Wise International LlcNot applicableNot applicableCanada
Micro ZnSolution5 mgIntravenousSandoz Canada Incorporated1992-12-31Not applicableCanada
Micro ZnSolution1 mgIntravenousSandoz Canada Incorporated1992-12-31Not applicableCanada
Perioselect Zinc Chloride Solution 1%Solution1 %DentalSultan Healthcare1992-12-311996-09-06Canada
Zin Pro Tab 90mgTablet90 mgOralProfessional Health Products1991-12-311997-08-22Canada
ZincInjection, solution1 mg/mLIntravenousHospira, Inc.1986-06-26Not applicableUs
Zinc LozengesLozenge10 mgOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.Not applicableNot applicableCanada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Acti-ZN 25 CapletTablet25.0 mgOralActi Form Ltd.1991-12-312005-03-21Canada
Action CreamCream.15 g/75gTopicalNeat Feat Products2013-04-07Not applicableUs
Advanced Jellyfish Sting KitPowder, for suspension.001 mg/mLTopicalPhillips Company2010-11-12Not applicableUs
BabyB BabySaverCream1 g/50gTopicalNeat Feat Products2013-04-07Not applicableUs
BabyB BabySaverCream15 g/150gTopicalNeat Feat Products2013-04-07Not applicableUs
BodysaverCream.15 g/75gTopicalNeat Feat Products2013-04-07Not applicableUs
Chelated Mega Zinc Tab 75mgTablet75 mgOralRheingold Food International Ltd.1985-12-312001-07-06Canada
Chelated Zinc Hvp Chelate 50mg - TabTablet50 mgOralInternational Nutrition Ltd.1996-07-262001-08-17Canada
Chelated Zinc Tab 10mgTablet10 mgOralJamieson Laboratories Ltd1975-12-312006-07-25Canada
Chelated Zinc Tab 25mgTablet25 mgOralPharmavite1991-12-311998-09-08Canada
Chelated Zinc TabletsTablet15 mgOralAlbion1996-09-062002-09-30Canada
Chewable Zinc Wafers 10mgTablet10 mgOralShaklee Corporation1986-12-312003-07-25Canada
Derma GranSpray.1 g/100gTopicalDerma Sciences2015-04-20Not applicableUs
DermadroxSpray.531 g/118mLTopicalGeritrex Llc2015-07-31Not applicableUs
Dermagran II Moisturiz.spray-liq Top 1mg/mlLiquid1 mgTopicalCanderm G.P.1998-05-072008-08-06Canada
Dermagran II Moisturizing Spray 1mg/mlLiquid1 mgTopicalCanadian Medical Supply Inc.1993-12-311996-09-09Canada
Dermagran II Moisturizing Spray-1mg/mlLiquid1 mgTopicalTrans Canaderm Inc.1996-01-011996-09-10Canada
Diabetic Skin Care FormulaSoap.0025 mg/mgTopicalK5 Brands, Llc2016-03-31Not applicableUs
Fisherman's Friend Zinc LozengesLozenge5 mgOralLofthouse Of Fleetwood Ltd.1999-08-152003-06-20Canada
Halls Zinc DefenseLozenge5.5 mgOralWarner Lambert Canada Inc.Not applicableNot applicableCanada
Herbon Zinc LozengesLozenge5 mgOralHerbon Naturals Inc.1997-09-232005-09-29Canada
IvyMedLiquid.001 mg/mLTopicalPhillips Company2010-08-23Not applicableUs
Nutra ZincTablet50 mgOralNatural Healthcare Clinic Nutrition Centre2002-07-192006-08-02Canada
Opti-zinc 25 CapletTablet25.0 mgOralNu Life Nutrition Ltd.1991-12-312005-03-15Canada
Port A Mins Super Zinc 15Tablet15 mgOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Port A Mins Super Zinc 30Tablet30 mgOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Prosol Astringent Irrigating Medicament LiqLiquid.15 %DentalDentsply Caulk1994-12-311996-11-05Canada
Prostana Cap 2.5mgCapsule2.5 mgOralAnabolic Laboratories Inc.1982-12-312002-10-18Canada
Senior BCream1.5 g/75gTopicalNeat Feat Products2013-07-10Not applicableUs
Spectralsine Tab 10mgTablet10 mgOralNf Formulas Inc.1983-12-312000-06-21Canada
StaphWash PlusLiquid.001 mg/mLTopicalPhillips Company2010-08-23Not applicableUs
StaphWash PlusLiquid.001 mg/mLTopicalPhillips Company2010-08-23Not applicableUs
StingMedLiquid.001 mg/mLTopicalPhillips Company2010-08-23Not applicableUs
VenomXLiquid.001 mg/mLTopicalPhillips Company2010-08-23Not applicableUs
Zigg-eezeLozenge13.3 mgOralThe Quigley Corporation1998-09-282002-09-18Canada
Zinc - 25mg TabTablet25 mgOralCreative Nutrition Canada Corp.1994-12-312004-08-04Canada
Zinc (gluconate) 10 Mg TabletsTablet10 mgOralGeneral Nutrition Canada Inc.1997-04-182005-08-05Canada
Zinc 10mgTablet10 mgOralGamme Nature1990-12-312004-07-26Canada
Zinc 25mg TabTablet25 mgOralNutricorp International1993-12-312009-08-05Canada
Zinc 50 CapletTablet50 mgOralHealth Wise Nutrition Inc.1994-12-312002-07-18Canada
Zinc 50 mgTablet50 mgOralPreferred Nutrition Inc.2004-05-122005-08-04Canada
Zinc 50 Mg - TabTablet50 mgOralSantÉ Naturelle (Ag) LtÉe1996-06-162002-06-18Canada
Zinc 50mgTablet50 mgOralGamme Nature1986-12-312008-07-31Canada
Zinc 50mg TabTablet50 mgOralJamieson Laboratories Ltd1994-12-311996-09-10Canada
Zinc Caps 50mgCapsule50 mgOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Zinc Chelated 50mg TabTablet50 mgOralBioforce Canada Inc.1985-12-311997-07-22Canada
Zinc Citrate - Cap 30mgCapsule30 mgOralSisu Inc.1996-07-302006-07-31Canada
Zinc Citrate Chelate Tab 50mgTablet50 mgOralGahler Enterprises Ltd.1979-12-312008-07-17Canada
Zinc Citrate Tab 15mgTablet15 mgOralGahler Enterprises Ltd.1990-12-312008-07-17Canada
Zinc Complex 30mg TabTablet30 mgOralBioforce Canada Inc.1985-12-311997-07-22Canada
Zinc Dietary SupplementTablet25 mgOralGarden State Nutritionals1998-08-312000-06-07Canada
Zinc FormulaCapsule30 mgOralSeroyal International Inc.1993-12-312009-07-06Canada
Zinc Gluconate 380mgTablet50 mgOralLaboratoire Lalco Inc.1998-06-052002-09-05Canada
Zinc Gluconate Tab 10mgTablet10 mgOralLaboratoire Lalco Inc.1977-12-312002-09-05Canada
Zinc Gluconate Tab 10mgTablet10 mgOralSuperco Enr.1984-12-312000-10-31Canada
Zinc Gluconate Tab 10mgTablet1.37 mgOralBio Vita1987-12-311997-08-07Canada
Zinc Gluconate Tab 10mgTablet10 mgOralPharmetics (2011) Inc.1979-12-312006-07-27Canada
Zinc Gluconate Tab 50mgTablet50 mgOralSwiss Herbal Remedies Ltd.1978-12-311999-04-05Canada
Zinc Liquid- 15mg/5mlLiquid15 mgOralMetagenics, Inc.1997-02-012008-08-28Canada
Zinc Lozenge 9.9mgLozenge9.9 mgOralNutri West Products Ltd.1993-12-312002-06-14Canada
Zinc LozengesLozenge10 mgOralHerbalife International Of America1999-11-012002-09-17Canada
Zinc Lozenges With Non-medicinal EchinaceaLozenge5 mgOralHolista Health (Canada) Inc.1997-08-262001-08-01Canada
Zinc Oral SprayLiquid5 mgOralWn Pharmaceuticals Ltd.2001-11-232009-09-28Canada
Zinc Tab 10mgTablet10 mgOralEverest Pharmaceuticals Ltd.1980-12-311999-07-14Canada
Zinc Tab 10mgTablet10 mgOralHerbes Universelles Inc.1988-12-312009-07-15Canada
Zinc Tab 10mgTablet10 mgOralWampole Brands, A Division Of Pangeo Pharma (Canada) Inc.1979-12-312002-07-29Canada
Zinc Tab 10mgTablet10 mgOralCountry Health Laboratories Ltd.1982-12-312001-07-27Canada
Zinc Tab 10mgTablet10 mgOralVita Health Products Inc1975-12-312004-07-26Canada
Zinc Tab 10mgTablet10 mgOralAlbi Naturals1979-12-312008-07-17Canada
Zinc Tab 15mgTablet15 mgOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Zinc Tab 20mgTablet20 mgOralHillestad Pharmaceuticals Usa1997-09-242009-09-22Canada
Zinc Tab 25mg Hvp ChelatedTablet25 mgOralGahler Enterprises Ltd.1988-12-312008-07-17Canada
Zinc Tab 50mgTablet50 mgOralAlbi Naturals1979-12-312008-07-17Canada
Zinc Tab 50mgTablet50 mgOralPharmavite1987-12-312006-07-03Canada
Zinc Tab 50mgTablet50 mgOralLes Produits Gerbex Inc.1989-12-312005-06-29Canada
Zinc Tab 50mgTablet50 mgOralCountry Health Laboratories Ltd.1982-12-312001-07-27Canada
Zinc Tab 50mg ChelatedTablet50 mgOralAlive Vitamins1987-12-312002-07-12Canada
Zinc Tablets 25mgTablet25 mgOralRoyal Bodycare Canada Inc.1992-12-312005-08-02Canada
Zinc Tablets 50mgTablet50 mgOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1980-12-312002-07-31Canada
Zinc Tablets 50mgTablet50 mgOralShoppers Drug Mart Inc.1979-12-311997-08-15Canada
Zincitrate Cap 30mgCapsule30 mgOralProfessional Health Products1997-06-012008-07-28Canada
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixtures
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
4 Trace Elements Injection, USPSolutionIntravenousHospira, Inc.1983-12-31Not applicableCanada
A + ZincTabletOralNutrilite, A Division Of Access Business Group, Llc2000-09-012007-07-06Canada
A.B.C. Formula #1TabletOralVallee Import/Export1997-01-011999-06-28Canada
A.R.T.H. Away FormulaCapsuleOralAbundance Marketing Ltd.1999-02-012006-06-16Canada
Acetabolan III Vitamin and Mineral SupplementCapsuleOralIovate Health Sciences International Inc.2003-12-052007-07-18Canada
Acetabolan-II Vitamin and Mineral SupplementCapsuleOralIovate Health Sciences International Inc.2000-11-202005-06-21Canada
Acti-cal/mag 2:1 + Zinc and D CapletTabletOralActi Form Ltd.1991-12-312005-03-21Canada
Acti-carotene + Zn CapletTabletOralActi Form Ltd.1991-12-312005-03-21Canada
Acti-retinol & Zn CapletTabletOralActi Form Ltd.1991-12-312005-03-03Canada
ActyformCapsuleOralTechnodiet S.E.N.C.1999-10-262008-08-13Canada
Adrenergy TabletsTabletOralMorter HealthsystemNot applicableNot applicableCanada
Allergic Itch ReliefCreamTopicalValue Merchandisers2011-12-01Not applicableUs
Allergy CreamCreamTopicalGw Pharmaceuticals Ltd.2003-07-222011-08-22Canada
AmdCapsuleOralSeroyal International Inc.1997-06-272009-07-06Canada
Anti ItchCreamTopicalMeijer Distribution2010-03-17Not applicableUs
Anti Itch and Skin ProtectantCreamTopicalRite Aid2005-07-30Not applicableUs
Anti Itch CreamCreamTopicalNeopharm Co., Ltd2010-09-07Not applicableUs
Anti Itch SpraySprayTopicalH.J. Sutton Industries Ltd.Not applicableNot applicableCanada
Anti itch Topical AnalgesicCreamTopicalChain Drug Marketing Association2014-02-20Not applicableUs
Anti-ItchCreamTopicalAmerisource Bergen2005-09-20Not applicableUs
Anti-Itch CreamCreamTopicalTrifecta Pharmaceuticals Usa, Llc.2016-12-29Not applicableUs
Anti-Itch Extra StrengthCreamTopicalPersonal Care Products2013-07-10Not applicableUs
Anti-Itch Maximum StrengthCreamTopicalFred's2008-08-08Not applicableUs
Anti-itch Plus CreamCreamTopicalTaro Pharmaceuticals, Inc.Not applicableNot applicableCanada
Anti-Itch Wal-DrylSprayTopicalWalgreens2011-07-08Not applicableUs
ArmaxTabletOralEnzymatic Therapy, Inc.1997-03-202001-08-02Canada
Atopalm Itch ReliefCreamTopicalNeopharm Co., Ltd2011-03-16Not applicableUs
AvaptaSprayOralNeel Products LLC2012-08-162015-12-29Us
B & J Formula Dietary SupplementTabletOralGarden State NutritionalsNot applicableNot applicableCanada
BanophenCreamTopicalMajor2009-06-19Not applicableUs
Benadryl Bug Bite ReliefLiquidTopicalMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2007-03-09Not applicableCanada
BENADRYL Extra Strength Itch CoolingSprayTopicalJohnson & Johnson2012-03-22Not applicableUs
Benadryl Extra Strength Itch ReliefSolutionTopicalJohnson & Johnson2012-04-01Not applicableUs
Benadryl Extra Strength Itch StoppingCreamTopicalJohnson & Johnson2012-10-15Not applicableUs
Benadryl Original Strength Itch StoppingCreamTopicalJohnson & Johnson2012-10-15Not applicableUs
Benadryl ReadyMist Itch StoppingSprayTopicalJohnson & Johnson2014-10-062016-12-01Us
Benadryl SpraySprayTopicalMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2007-03-09Not applicableCanada
Benzocaine, Menthol, Zinc ChlorideCreamTopicalChurch & Dwight Company, Inc.2017-02-20Not applicableUs
Beta Carotene PlusTabletOralNu Life Nutrition Ltd.1986-12-312000-05-23Canada
Beta-carotene 25000 Plus Zinc CapletTabletOralNu Life Nutrition Ltd.1991-12-312005-03-15Canada
Beta-retinol + Zinc CapletTabletOralNu Life Nutrition Ltd.1991-12-312000-03-03Canada
Bio-b12CapsuleOralThorne Research Inc.1997-09-092006-08-04Canada
Blistex Ivarest Poison Ivy ItchSprayTopicalBlistex Corporation2015-02-02Not applicableUs
BseltzerGranule, effervescentOralAbundance Marketing Ltd.2001-11-112007-07-23Canada
C 106 TabTabletOralNf Formulas Inc.1983-12-312001-09-18Canada
C-1000 Plus Zinc & PotassiumTabletOralNu Life Nutrition Ltd.1987-12-312005-03-15Canada
C-forceCapsuleOralPrairie Naturals1997-04-012002-06-21Canada
C-plus - TabTabletOralChampion's Choice Advanced Nutrition Inc.1997-06-111999-08-28Canada
C.A.G. TabTabletOralNutrition For Life International1996-11-272000-08-11Canada
Cal & Mag Hvp Chel Plus C Potass & Zinc TabTabletOralGahler Enterprises Ltd.1989-12-312000-09-05Canada
Cal Mag Plus - TabTabletOralNutrilite, A Division Of Access Business Group, Llc1995-12-312007-07-06Canada
Cal-mag (one To One) With Potass & ZincTabletOralGahler Enterprises Ltd.1988-12-311999-01-27Canada
Cal-mag Citrate Zinc & Vitamin D TabletsTabletOralSwiss Herbal Remedies Ltd.Not applicableNot applicableCanada
Cal-mag Complete With Zinc, C and DTabletOralQuest Vitamins A Div Of Purity Life Health Products1992-12-312009-07-14Canada
Cal-mag Plus K, Mn and Zn CapletsTabletOralHealth Wise Nutrition Inc.1994-12-311999-08-13Canada
Cal-mag Vitamin C and Zinc TabTabletOralSwiss Herbal Remedies Ltd.1991-12-312004-09-03Canada
Cal-mag With Zinc & Vitamin DTabletOralHealth Wise Nutrition Inc.2000-06-092002-07-18Canada
Cal/mag 1:1 With Zinc and Vitamin D - TabletTabletOralHealth Wise Nutrition Inc.1997-08-152002-07-18Canada
Caladryl ClearLotionTopicalValeant Pharmaceuticals North America2013-08-16Not applicableUs
Calcium Mg and Zn Capsules With Vitamin DCapsuleOralRheingold Food International Ltd.1995-12-312007-07-26Canada
Calcium & Magnesium Citrate Plus D With Manganese, Potassium & ZincTabletOralNatural Factors Nutritional Products Ltd.1998-12-142008-07-17Canada
Calcium & Magnesium Plus Potassium & ZincTabletOralNatural Factors Nutritional Products Ltd.1998-12-212009-09-28Canada
Calcium & Magnesium Plus Potassium, Zinc, & ManganeseCapsuleOralNatural Factors Nutritional Products Ltd.2000-04-272008-07-17Canada
Calcium & Magnesium With Potassium & ZincTabletOralWn Pharmaceuticals Ltd.2000-08-302005-08-15Canada
Calcium & Magnesium With Potassium, Zinc, Manganese & Vitamin DTabletOralWn Pharmaceuticals Ltd.2000-08-302005-08-15Canada
Calcium and Mag-potass and Zinc CapCapsuleOralGahler Enterprises Ltd.1991-12-312001-07-26Canada
Calcium and Magnesium 1:1 Plus TabletsTabletOralAlbi Naturals1998-02-202009-07-15Canada
Calcium and Magnesium W Zinc TabTabletOralPharmavite1987-12-312005-07-15Canada
Calcium and Magnesium With ZincTabletOralVita Health Products Inc1998-09-152002-07-31Canada
Calcium Complex High GradeCapsuleOralNew Spirit Naturals, Inc.Not applicableNot applicableCanada
Calcium Et Magnesium Plus Vitamine D/fe/znTabletOralLaboratoire Lalco Inc.1993-12-312008-07-29Canada
Calcium PlusTabletOralLaboratoire Riva IncNot applicableNot applicableCanada
Calcium With Mg Zn Mn Cu CR Si and Vit. C & DTabletOralJamieson Laboratories Ltd1993-12-312001-09-14Canada
Calcium-magnesium With K & Zn and Vitamin D3CapsuleOralHolista Health (Canada) Inc.1997-08-152002-08-06Canada
Calcium, Magnesium, Zinc and DCapsuleOralNutravite Pharmaceuticals Inc.1999-08-032007-07-17Canada
Caldyphen ClearLotionTopicalAmerisource Bergen2008-01-01Not applicableUs
CalplusTabletOralLifestyles Canada Corporation1998-08-072000-07-16Canada
Careone AllergyCreamTopicalAmerican Sales Company2012-03-01Not applicableUs
Carti-aide TabTabletOralAvant Garde, Les SupplÉments1995-12-311998-07-08Canada
Cell-wiseTabletOralMelaleuca, Inc.1998-01-122004-07-30Canada
Cell-wise Natural SourceTabletOralMelaleuca, Inc.1998-05-262005-06-28Canada
Chela Calmag-100 Plus Zinc D3TabletOralNu Life Nutrition Ltd.1987-12-312000-03-03Canada
Chela Calmag-300 Plus Zinc D3TabletOralNu Life Nutrition Ltd.1987-12-312000-03-03Canada
Chela Zinc PlusTabletOralNu Life Nutrition Ltd.1987-12-312000-03-03Canada
Chelated Cal-mag(2:1)with Zn Vit.c and DTabletOralHealth Wise Nutrition Inc.1995-12-312002-07-18Canada
Chelated Cal/mag/zn With VitaminsTabletOralHealth Wise Nutrition Inc.2000-04-072002-07-18Canada
Chewable Calcium Plus Magnesium and MineralsTabletOralNatures Sunshine Products, Inc.1998-01-262002-08-23Canada
ChromagenCapsuleOralAvion Pharmaceuticals, Llc2017-01-23Not applicableUs
Chromease TabTabletOralAnabolic Laboratories Inc.1981-12-312004-03-15Canada
Citrate De Calcium Plus Vitamine D Et ZincTabletOralSantÉ Naturelle (Ag) LtÉe2000-06-282003-07-10Canada
Clear Anti ItchLotionTopicalVi Jon1994-05-07Not applicableUs
Clear Anti-ItchLotionTopicalTarget Cop1996-03-31Not applicableUs
Clear Anti-itch LotionLotionTopicalPerrigo International1998-08-172001-03-07Canada
Complete Multivitamins and Minerals Tablets Timed ReleaseTablet, extended releaseOralPharmetics (2011) Inc.1999-07-262009-07-30Canada
Copper 3mg Plus Iron & Zinc TabTabletOralSwiss Herbal Remedies Ltd.1986-12-312000-08-03Canada
CVS Extra Strength Itch ReliefOintmentTopicalCvs Health2010-09-13Not applicableUs
CVS Itch ReliefLotionTopicalCvs Health2008-01-01Not applicableUs
CVS Pharmacy Mouth SoreGel, dentifriceDentalCvs Health2012-11-01Not applicableUs
CVS Pharmacy Mouth Sore GelGel, dentifriceOralCvs Health2012-10-01Not applicableUs
Derma-forceCapsuleOralPrairie Naturals1997-04-012006-09-20Canada
Dermagran Moisturizing SpraySprayTopicalCanadian Medical Supply Inc.1987-12-311996-09-09Canada
Dermamine Extra Strength Itch StoppingCreamTopicalNatureplex, LLC2014-03-01Not applicableUs
Dg Health Anti ItchCreamTopicalDolgencorp2010-03-16Not applicableUs
DiaplexTabletOralNephro Tech, Inc.2002-07-102004-07-23Canada
Dinosaurs Im-rapWaferOralNutraceutical CorporationNot applicableNot applicableCanada
DiphenhydramineCreamTopicalPhysicians Total Care, Inc.2008-04-23Not applicableUs
Diphenhydramine DCreamTopicalNexmed Usa Inc2011-08-29Not applicableUs
Diphenhydramine HCl and Zinc AcetateCreamTopicalPerrigo New York Inc.2005-12-05Not applicableUs
Diphenhydramine Hydrochloride and Zinc AcetateCreamTopicalTaro Pharmaceuticals U.S.A., Inc.2005-09-20Not applicableUs
Dr. Sheffield Anti Itch CreamCreamTopicalFaria Llc Dba Sheffield Pharmaceutcials2008-11-11Not applicableUs
E & I FormulaeCapsuleOralEnrich InternationalNot applicableNot applicableCanada
E.S.T. ComplexTabletOralAbundance Marketing Ltd.2000-12-062004-06-30Canada
E.V.C. Vitamins TabTabletOralSisu Inc.1985-12-312009-08-04Canada
EC + ComplexCapsuleOralSeroyal International Inc.1998-12-312009-07-06Canada
Efferlife Multivitamins and MineralsTablet, effervescentOralNaturale Science Inc.2001-10-012006-10-10Canada
Eky Efferlife Vitamin C 1000mg With ZincTablet, effervescentOralNaturale Science Inc.2003-06-212006-10-10Canada
Enviroflex - TabTabletOralEnviro Tech International Canada1997-09-151999-07-26Canada
Equaline Anti ItchCreamTopicalSupervalu2014-03-28Not applicableUs
Equaline Anti-itchCreamTopicalSupervalu2005-09-20Not applicableUs
Equate Anti ItchCreamTopicalWalmart Stores2005-06-29Not applicableUs
EscaviteTablet, chewableOralGm Pharmaceuticals2012-02-01Not applicableUs
Evc - LiqLiquidOralSisu Inc.1994-12-312007-07-20Canada
Evc Liquid Vitamins A,c,b6 With Beta Caro&znLiquidOralNf Formulas Inc.1992-12-312008-06-26Canada
Extra Strength Wal-dryl Itch ReliefSprayTopicalWalgreen2011-01-03Not applicableUs
Family Care Anti-ItchCreamTopicalUnited Exchange Corporation2014-11-24Not applicableUs
Family WellnessCreamTopicalZhejiang Jingwei Pharmaceutical Co., Ltd.2013-11-01Not applicableUs
Female AdvantageCapsuleOralBody Wise International LlcNot applicableNot applicableCanada
Folcaps Care OneCapsule, gelatin coatedOralMidlothian Laboratories2009-05-01Not applicableUs
Folet OneCapsule, liquid filledOralPronova Corporation2014-06-01Not applicableUs
Formula 14 Dietary SupplementCapsuleOralRx Vitamins Inc.2004-12-062007-10-25Canada
Formula A.R.-th Dietary SupplementCapsuleOralRx Vitamins Inc.2004-04-042007-10-25Canada
Formula BCapsuleOralBalance Plus, Inc.2000-04-192004-08-17Canada
Formula CnCapsuleOralBalance Plus, Inc.2000-02-092004-08-17Canada
Formula Csp With Vitamins A C and Zinc LozLozengeOralQuantum, Inc.1997-09-172005-08-01Canada
Formula ECTabletOralBody Wise International LlcNot applicableNot applicableCanada
Formula Est'ro Tab SupportCapsuleOralBalance Plus, Inc.2000-02-172004-08-17Canada
Formula Im-vitamins and Minerals TabTabletOralMetagenics, Inc.1997-01-272006-08-14Canada
Formula Imgrd - TabTabletOralHealth Wise Nutrition Inc.1997-08-152002-07-18Canada
Formula InfCapsuleOralBalance Plus, Inc.2000-02-092004-08-17Canada
Formula IntCapsuleOralBalance Plus, Inc.2000-02-092004-08-17Canada
Formula Ma-vitamin E & Zinc TabTabletOralMetagenics, Inc.1996-12-292002-10-07Canada
Formula OCapsuleOralGeneral Nutrition Canada Inc.1997-09-122005-08-05Canada
Formula O-care Vitamin and Mineral SupplementTabletOralFor Mor International Inc.2000-03-252002-06-25Canada
Formula R Mineral SupplementTabletOralFor Mor International Inc.2000-03-252003-08-29Canada
Fortifi-plusCapsuleOralClinique Lafontaine Inc, Division Les Importations Ortho1998-01-222008-08-07Canada
Freezone LiqLiquidTopicalWhitehall Robins Inc.1993-12-311997-08-07Canada
G-bucal-CSprayOropharyngealMclaren Medical Inc2012-01-01Not applicableUs
Glyco-aide TabTabletOralAvant Garde, Les SupplÉments1995-12-311998-07-08Canada
Golf Vitamin and Mineral SupplementLiquidOralMuscle Marketing Usa Inc.2001-02-242008-06-27Canada
Good Neighbor Pharmacy Itch Relief Extra StrengthAerosol, sprayTopicalAmerisource Bergen Drug Corportaion2011-10-28Not applicableUs
Good Sense Itch ReliefCreamTopicalL. Perrigo Company2006-07-18Not applicableUs
Guardyn TabTabletOralNutri Dyn Products Ltd.1986-12-311998-08-13Canada
GumsolSolutionOralKramer Novis.2014-02-28Not applicableUs
Harris Teeter Anti-ItchCreamTopicalHarris Teeter2017-04-21Not applicableUs
Healthy Accents Anti ItchCreamTopicalDza Brands,2010-07-21Not applicableUs
Hi Potency B Complex W Chelated MineralsTabletOralKlaire Labs Inc.1984-12-312004-01-19Canada
Humco CalaclearLotionTopicalHumco Holding Group. Inc.1998-03-25Not applicableUs
Hvp Chelated Cal/mag With Zinc and Vitamins C and DTabletOralDarwen Holdings Ltd.Not applicableNot applicableCanada
Hypo Vites TabTabletOralPharmetics (2011) Inc.1977-12-312006-07-27Canada
I-care Multivitamin and Multimineral TabletsTabletOralPharmetics (2011) Inc.2002-05-302009-07-30Canada
IcapsTabletOralAlcon, Inc.1994-12-312009-04-24Canada
Icaps Time ReleaseTabletOralAlcon, Inc.1997-06-202001-08-14Canada
ImedeenTabletOralNordic Selfcare Institute P Technologies Int'l (Pti) Inc.1998-06-302000-02-09Canada
Imm FormulaTabletOralAbundance Naturally LtdNot applicableNot applicableCanada
Imm Formula CapCapsuleOralNatures Sunshine Products, Inc.1990-12-312001-07-31Canada
Instant Itch Relief CVSSprayTopicalCvs Health2014-11-13Not applicableUs
Iron W Zinc Chelated W Liver TabTabletOralTrophic Canada Ltd.1977-12-311999-08-12Canada
Itabs PlusTabletOralVita Health Products Inc2000-01-012002-07-31Canada
Itch Rel Spr CvsSprayTopicalCvs Health2014-02-14Not applicableUs
Itch ReliefCreamTopicalH.E.B.2010-09-15Not applicableUs
Itch Relief Clear Skin Protectant CVSSprayTopicalCvs Health2014-10-31Not applicableUs
Itch Relief CreamCreamTopicalPharmacy Vlaue Alliance Llc2016-07-19Not applicableUs
Itch Relief extra strengthCreamTopicalSafeway2008-11-20Not applicableUs
Itch Relief LotionLotionTopicalCrls2009-09-09Not applicableCanada
Itch Relief Medicated Pads CVSLiquidTopicalCvs Health2017-03-15Not applicableUs
Itch Relief SprayAerosolTopicalTender CorporationNot applicableNot applicableCanada
Itch Relief StickSolutionTopicalTender CorporationNot applicableNot applicableCanada
Itch StoppingCreamTopicalHyvee2015-09-27Not applicableUs
IV-8 FormulaCapsuleOralEnrich International1998-06-012000-07-28Canada
J.T. FormulaTabletOralChanges InternationalNot applicableNot applicableCanada
Kama Caze SyrupSyrupOralAlbi Naturals1996-12-312008-07-17Canada
Kanga-V Multivitamins & MineralsTablet, effervescentOralLacombe Drugs (1992) LtdNot applicableNot applicableCanada
Kanka SoftbrushGelOralBlistex Corporation2009-05-01Not applicableUs
Kc Vitamin and Mineral SupplementLiquidOralMuscle Marketing Usa Inc.2001-02-242008-06-27Canada
KDS Lab Liquid StypticLiquidTopicalKds Lab2012-10-03Not applicableUs
L.G.I.T.CapsuleOralMorinda Canada1999-12-152001-07-23Canada
Leader Anti Itch Maximum StrengthCreamTopicalCardinal Health2012-02-10Not applicableUs
LEADER Caldyphen ClearLotionTopicalCardinal Health2012-03-15Not applicableUs
Live Better Anti-ItchCreamTopicalThe Great Atlantic + Pacific Tea Company2005-09-20Not applicableUs
Lucky Itch StoppingCreamTopicalDelta Brands, Inc2014-11-15Not applicableUs
M T E 4 Concentrate InjLiquidIntravenousLyphomed, Division Of Fujisawa Canada Inc.1987-12-311997-08-14Canada
M.T.E.-4SolutionIntravenousPartners Health Care, Inc.1996-08-142008-02-15Canada
M.T.E.-4 ConcentratedSolutionIntravenousPartners Health Care, Inc.1987-12-302008-02-15Canada
M.T.E.-6 ConcentratedLiquidIntravenousLyphomed, Division Of Fujisawa Canada Inc.1993-12-311997-08-14Canada
MagnacalCapsuleOralHolista Health (Canada) Inc.2002-09-112008-07-17Canada
Magnesium and ZincTabletOralHealth Thru Herbs Inc.1985-12-312002-11-05Canada
MaxFeTabletOralPronova Corporation2014-06-01Not applicableUs
Meijer Anti-itchCreamTopicalMeijer Distribution2005-09-20Not applicableUs
Menocal TabTabletOralLes Aliments Nutri Source Inc.1994-12-312009-08-05Canada
Meth-X Vitamin and Mineral SupplementCapsuleOralDymatize Enterprises Inc.2002-01-102006-10-06Canada
MhbTabletOralVisiontel2002-11-082004-03-19Canada
Micro Plus 4 ConcentrateLiquidIntravenousSandoz Canada Incorporated1994-12-31Not applicableCanada
Micro Plus 4 Regular StrengthLiquidIntravenousSandoz Canada Incorporated1996-12-31Not applicableCanada
Micro Plus 5 ConcentrateLiquidIntravenousSandoz Canada Incorporated1994-12-31Not applicableCanada
Micro Plus 6 (concentrate)LiquidIntravenousSandoz Canada Incorporated1994-12-31Not applicableCanada
Micro Plus 6 (pediatric)LiquidIntravenousSandoz Canada Incorporated1994-12-31Not applicableCanada
Micro Plus 6 (regular)LiquidIntravenousSandoz Canada Incorporated1996-07-30Not applicableCanada
MineralexLiquidOralLand Art Inc.2001-11-122008-06-26Canada
Mte 4 InjLiquidIntravenousLyphomed, Division Of Fujisawa Canada Inc.1987-12-311997-08-14Canada
Multi Vitamin - MineralTabletOralEnrich International1999-11-112001-09-28Canada
Multi Vitamin-mineral FormulaTabletOralVita Health Products Inc1997-04-031998-01-16Canada
Multi Vitamins & MineralsTabletOralWn Pharmaceuticals Ltd.2000-01-122001-04-12Canada
Multi-vitamins With MineralsTabletOralWn Pharmaceuticals Ltd.2001-04-122009-09-28Canada
Multimineral ChelatesTabletOralW.R. Enterprises Inc.1984-12-312002-08-01Canada
Multiple Trace Metal Additive SolutionSolutionIntravenousInternational Medication Systems, Limited1982-12-311997-08-15Canada
Munit-E TabletTabletOralHolista Health (Canada) Inc.1996-12-312002-08-06Canada
N.U.T. ComplexTabletOralAbundance Marketing Ltd.2000-12-062004-06-30Canada
Nata KompleteTabletOralWh Nutritionals, Llc2011-06-252016-12-06Us
NbeSpray, meteredOralDynamic Pharmaceuticals2010-09-30Not applicableUs
Neo-vites & Minerals TabTabletOralNeolab Inc1987-12-311997-08-12Canada
NiferexTabletOralAvion Pharmaceuticals, Llc2017-01-23Not applicableUs
Nioxin Recharging ComplexCapsuleOralNioxin Research Laboratories, Inc.2002-06-192008-06-20Canada
Nutravite Calcium Magnesium and Zinc CapsCapsuleOralNutravite Pharmaceuticals Inc.1998-08-251999-08-07Canada
Nutri-chem Calcium Magnesium With D and ZincTabletOralNutri Chem Pharmacy Ltd2001-08-272009-08-19Canada
Nutrilite Double XTabletOralNutrilite, A Division Of Access Business Group, Llc2002-12-152008-06-24Canada
O-Cal FA multivitaminTabletOralPharmics, Inc.1970-01-15Not applicableUs
O-Cal Prenatal VitaminTabletOralPharmics, Inc.2002-01-23Not applicableUs
Ocuvite Vitamin and Mineral SupplementTabletOralBausch & Lomb Inc2003-07-302006-08-02Canada
Ocuvite Vitamin and Mineral Supplement CapsulesCapsuleOralBausch & Lomb Inc2001-10-312006-08-02Canada
OnccorTabletOralSimone Protective Pharmaceuticals, Inc.Not applicableNot applicableCanada
One A Day Advance AdultsTabletOralBayer Inc Consumer Care2002-09-122007-08-02Canada
One A Day Advance Adults 50+TabletOralBayer Inc Consumer Care2002-09-122007-08-02Canada
One A Day Advance FemTabletOralBayer Inc Consumer Care1999-03-012001-02-22Canada
One A Day TabTabletOralCountry Health Laboratories Ltd.1982-12-312001-07-27Canada
One A Day With Non-medicinal EchinaceaTabletOralBayer Inc Consumer Care2000-09-272002-08-01Canada
Optivite Vitamin and Mineral Supplement TabletTabletOralPharmetics (2011) Inc.1998-11-102005-08-04Canada
Orajel Denture Pain ReliefGelTopicalChurch & Dwight Company, Inc.2017-07-31Not applicableUs
Orajel Instant Pain Relief Maximum StrengthGelTopicalChurch & Dwight Company, Inc.2010-06-11Not applicableUs
Orajel Mouth-aidGelDental; TopicalDel Pharmaceuticals Inc.1986-12-312002-07-19Canada
Orajel Toothache RinseLiquidTopicalChurch & Dwight Company, Inc.2016-12-01Not applicableUs
Orifer FTabletOralSanofi Aventis1995-12-312007-11-22Canada
Osteo FormulaTabletOralSisu Inc.2001-02-012009-08-04Canada
Osteo-plusTabletOralRolmex International Inc.2000-09-152008-07-09Canada
OtozinSolutionTopicalAllegis Pharmaceuticals, LLC2011-05-062016-01-07Us
P & Sp Special FormulaCapsuleOralNutraceutical Corporation2005-11-012006-09-18Canada
P.R.O. ComplexTabletOralAbundance Marketing Ltd.2000-12-062004-06-30Canada
Polymine Avec Zinc Et CuivreTabletOralLes Laboratoires Vachon Inc.1985-12-312007-07-12Canada
Polysporin Itch ReliefLotionTopicalJohnson & Johnson2003-04-02Not applicableCanada
Powertech Vitamin and Mineral SupplementPowderOralDymatize Enterprises Inc.2002-09-182006-10-06Canada
PregvitTabletOralDuchesnay Inc.2003-08-252016-07-05Canada
Pregvit Folic 4TabletOralDuchesnay Inc.Not applicableNot applicableCanada
Pregvit Folic 5TabletOralDuchesnay Inc.2006-03-172016-07-05Canada
Premier Value AllergyCreamTopicalTAI GUK PHARM. CO., LTD.2010-09-17Not applicableUs
PreNatal Vitamins PlusTabletOralbryant ranch prepack2011-04-15Not applicableUs
Prenatal Vitamins Plus Low IronTabletOralPatrin Pharma2013-04-01Not applicableUs39328 0106 10 nlmimage10 df476fdb
Prolynium Vitamin and Mineral SupplementCapsuleOralT & T Nutrition Inc.Not applicableNot applicableCanada
Pros-gard Zinc and Vitamin B6 - CapsuleCapsuleOralHolista Health (Canada) Inc.1996-12-312002-08-06Canada
ProscareCapsuleOralHolista Health (Canada) Inc.1997-06-112002-08-06Canada
ProsgardCapsuleOralHolista Health (Canada) Inc.1996-12-312002-08-06Canada
Publix allergyCreamTopicalPublix Supermarkets, Inc.2005-09-20Not applicableUs
Q.T. Vitamin and Mineral Drink MixPowderOralGarden State NutritionalsNot applicableNot applicableCanada
QBx (formerly known as PHI-5, K041059)CreamTopicalBiocellerex, Inc.2015-07-142016-01-12Us
Quality Choice Extra Strength Anti ItchCreamTopicalChain Drug Marketing Association2012-02-13Not applicableUs
Reaphirm Plant Source DHACapsule, gelatin coatedOralEverett Laboratories, Inc.2011-12-05Not applicableUs
Rite Aid Maximum StrengthGel, dentifriceOralRite Aid2011-01-20Not applicableUs
Rite Aid Maximum Strength Itch ReliefSprayTopicalRite Aid2011-08-10Not applicableUs
S.H. Drink MixPowderOralWatkins Incorporated1998-04-302005-08-23Canada
SamsonTabletOralScandinavian Formulas Inc.1997-04-012001-07-24Canada
Select Brand Itch ReliefSprayTopicalSelect Brand2012-07-11Not applicableUs
Shopko Anti-ItchCreamTopicalShopko Stores Operating2005-09-20Not applicableUs
ShopRite Anti ItchCreamTopicalWakfern Food Corporation2013-11-18Not applicableUs
Signature Care Itch ReliefCreamTopicalSafeway2015-09-01Not applicableUs
Sincera - TabletsTabletOralScandinavian Formulas Inc.1997-04-082005-02-16Canada
Smart Sense Anti Itch Extra StrengthCreamTopicalKmart Corporation2011-02-16Not applicableUs
Smart Sense Itch StoppingCreamTopicalKmart Corporation2015-12-23Not applicableUs
Smart Sense Topical Analgesic Skin ProtectantCreamTopicalKmart Corporation2013-12-13Not applicableUs
SolarayCapsuleOralAhmed's Sunforce International Products Inc.Not applicableNot applicableCanada
Somavit Brand Vitamins and Minerals ComplexTabletOralSoma Health Products2000-01-152005-08-26Canada
Spectra 301 Vitamin and Mineral SuppTabletOralNf Formulas Inc.1986-12-312000-07-05Canada
Spectrum 2 CapCapsuleOralNf Formulas Inc.1988-12-312008-06-26Canada
SPF Rx - SPF 50 Spearmint Lip BalmLipstickTopicalCal Pharma Llc2017-07-31Not applicableUs
Stress Complex 600 Avec Vit E Cuivre ZincTabletOralFrega Inc.1995-12-312008-02-13Canada
Strovite Forte CapletTablet, coatedOralEverett Laboratories, Inc.1996-10-01Not applicableUs
Sunmark Anti-itchCreamTopicalMc Kesson2005-09-20Not applicableUs
Super 7 Vitamin and Mineral SupplementCapsuleOralT & T Nutrition Inc.Not applicableNot applicableCanada
Super Cal Mag PlusTabletOralShaklee Corporation2002-07-022006-11-13Canada
Super Daily No 2TabletOralW.R. Enterprises Inc.1990-12-312003-07-30Canada
Supplements De Vitamines Et MinerauxLiquidOralLand Art Inc.1999-08-022008-06-26Canada
Supravite Stress Avec Vit E Cuivre Et ZincTabletOralPharmalab Inc.1985-12-311997-08-08Canada
Surbex-500 With ZincTabletOralAbbott1986-12-312008-06-06Canada
T-PA CapCapsuleOralSeroyal International Inc.1993-12-311997-08-14Canada
Tar-endCapsuleOralNatures Sunshine Products, Inc.1999-05-252006-07-10Canada
Tecnu CalagelGelTopicalTec Laboratories, Inc.1992-10-09Not applicableUs
Thymunase TabTabletOralAnabolic Laboratories Inc.1983-12-312004-03-15Canada
Tianshi Vital Powder IPowderOralTianjin Tianshi Group Co., Ltd.Not applicableNot applicableCanada
Tianshi Vital Powder IIPowderOralTianjin Tianshi Group Co., Ltd.Not applicableNot applicableCanada
TopCare Anti-ItchCreamTopicalTopco Associates2005-09-20Not applicableUs
Trace Elements for Injection - Liq IVLiquidIntravenousFaulding Consumer, Inc.1998-06-152001-07-30Canada
Trace Elements Solution InjSolutionIntravenousDavid Bull Laboratories (Pty) Ltd.1991-12-311998-08-13Canada
Trace Minerals Et/and B12 TabTabletOralTherapeutic Foods Co.1989-12-312003-07-16Canada
Ultra HrTabletOralNatural Organics Inc.Not applicableNot applicableCanada
Up and Up itch reliefCreamTopicalTarget Corporation.2009-11-30Not applicableUs
Usana Multimineral TabletsTabletOralUsana Health Sciences, Inc.1997-03-212002-07-22Canada
Usana Multimineral Tablets - TabTabletOralUsana Health Sciences, Inc.1997-02-171997-08-12Canada
V-V Dietary SupplementTabletOralGarden State NutritionalsNot applicableNot applicableCanada
Vimeral TabTabletOralIcn Pharmaceuticals1979-12-312005-04-26Canada
Vit-HA Multi Vitamin and Zinc SupplementTabletOralRheingold Food International Ltd.1994-12-312007-07-26Canada
Vita Day TabTabletOralJamieson Laboratories Ltd1993-12-311997-08-13Canada
Vitafol OB CapletTabletOralExeltis Usa, Inc.2002-12-02Not applicableUs
Vitafol OneCapsule, gelatin coatedOralEverett Laboratories, Inc.2011-06-13Not applicableUs
Vitafol PlusCapsule, liquid filledOralEverett Laboratories, Inc.2012-04-23Not applicableUs
Vitalife - CapsuleCapsuleOralHolista Health (Canada) Inc.1996-11-132002-08-06Canada
Vitality Brand Calcium Plus TabTabletOralGolden Neo Life Diamite International, Limited1993-12-311998-07-28Canada
Vitamin and Mineral Supplement CapsulesCapsuleOralVita Health Products Inc2004-01-052005-07-20Canada
Vitamin C & Zinc TabTabletOralPep Products Inc.1991-12-311999-10-29Canada
Vitamin C + Zinc TabTabletOralHillestad Pharmaceuticals Usa1989-12-312009-09-22Canada
Vitamin C and Zinc LozengesLozengeOralRx Vitamins Inc.1998-09-252007-10-25Canada
Vitamin E + 3 Extra Strength With ZincTabletOralWn Pharmaceuticals Ltd.2000-12-012009-09-28Canada
Vitogen B Stress C Vit E Zinc & CopTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1984-12-312002-07-31Canada
Vp-zelTablet, coatedOralVirtus Pharmaceuticals2012-03-01Not applicableUs
Vtb Vitamin and Mineral SupplementTabletOralGarden State NutritionalsNot applicableNot applicableCanada
Wal-drylCreamTopicalWalgreen2014-03-27Not applicableUs
Wal-dryl Itch ReliefCreamTopicalWalgreen2006-01-18Not applicableUs
Walgreens Anti ItchCreamTopicalWalgreen2012-03-01Not applicableUs
Walgreens Original Strength Anti ItchCreamTopicalWalgreen2013-09-27Not applicableUs
Weeks and Leo Extra Strength Itch StoppingCreamTopicalWeeks & Leo Co., Inc.2014-03-17Not applicableUs
Western Family Itch ReliefCreamTopicalWestern Family Food, Inc.2013-04-30Not applicableUs
WinCo Original Strength Anti-ItchCreamTopicalWin Co Foods, Llc,2014-02-09Not applicableUs
Women's FormulaTabletOralPro Ma Systems1998-10-312007-09-25Canada
Z-force Vitamin and Mineral SupplementCapsuleOralDymatize Enterprises Inc.2001-12-122006-10-06Canada
Z-mass PM Vitamin and Mineral SupplementCapsuleOralCytodyne Technologies Inc.2001-02-282004-10-22Canada
Zinc 50mg TabTabletOralSantÉ Naturelle (Ag) LtÉe1992-12-311997-09-09Canada
Zinc 50mg W Vitamin CTabletOralFoodscience Laboratories, Division Of Foodscience Corporation1986-12-311997-05-08Canada
Zinc Amino Acid Chelate TabTabletOralQuest Vitamins A Div Of Purity Life Health Products1979-12-311999-01-07Canada
Zinc and Algin Tab Nu LifeTabletOralNu Life Nutrition Ltd.1975-12-312000-03-03Canada
Zinc and Vitamin C LozengesLozengeOralHealth Wise Nutrition Inc.1997-08-152000-07-29Canada
Zinc Chelate 20mg With Copper ChelateTabletOralWn Pharmaceuticals Ltd.1999-11-292005-08-15Canada
Zinc Lozenge With Vitamin CTabletOralWn Pharmaceuticals Ltd.1998-05-202000-01-06Canada
Zinc Lozenges With Vitamin CLozengeOralAshbury Research CorporationNot applicableNot applicableCanada
Zinc Lozenges With Vitamin C and Non-medicinal EchinaceaLozengeOralVita Health Products Inc1999-05-212002-07-31Canada
Zinc Lozenges With Vitamin C In A Nonmedicinal Base With Echinacea LozengeLozengeOralPurity Life Health Products A Division Of Sunopta Inc.2002-06-012007-07-26Canada
Zinc Plus Extra CLozengeOralAmerifit Inc.Not applicableNot applicableCanada
Zinc Plus LozengesLozengeOralSwiss Herbal Remedies Ltd.1998-05-292009-08-04Canada
Zinc Plus Vitamin B6 TabTabletOralMetagenics, Inc.1995-12-312001-10-05Canada
Zinc Plus Vitamins C & B6 LozengesLozengeOralVita Plus Industries Inc.Not applicableNot applicableCanada
Zinc With B-carotene TabTabletOralEnrich International1994-12-312001-09-28Canada
Zinc With C - LozLozengeOralMetagenics, Inc.1997-02-012005-08-19Canada
Zinc With C LozengeLozengeOralNatures Sunshine Products, Inc.1998-01-262000-07-14Canada
Zinc With Vitamin C LozengesTabletOralPrairie Naturals2002-01-152004-10-07Canada
Zinc-C LozengesLozengeOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Zinc-C-lozengesLozengeOralRheingold Food International Ltd.1994-12-312007-07-26Canada
Zymain TabTabletOralAnabolic Laboratories Inc.1985-12-312004-03-15Canada
Categories
UNIIJ41CSQ7QDS
CAS number7440-66-6
WeightAverage: 65.409
Monoisotopic: 63.929146578
Chemical FormulaZn
InChI KeyHCHKCACWOHOZIP-UHFFFAOYSA-N
InChI
InChI=1S/Zn
IUPAC Name
zinc
SMILES
[Zn]
Pharmacology
IndicationNot Available
Structured Indications
PharmacodynamicsNot Available
Mechanism of action
TargetKindPharmacological actionActionsOrganismUniProt ID
B1 bradykinin receptorProteinunknownNot AvailableHumanP46663 details
Methylated-DNA--protein-cysteine methyltransferaseProteinunknownNot AvailableHumanP16455 details
Fructose-bisphosphate aldolase AProteinunknownNot AvailableHumanP04075 details
Elongation factor 1-alpha 1ProteinunknownNot AvailableHumanP68104 details
Alpha-enolaseProteinunknownNot AvailableHumanP06733 details
Glyceraldehyde-3-phosphate dehydrogenase, testis-specificProteinunknownNot AvailableHumanO14556 details
Nucleoside diphosphate kinase AProteinunknownNot AvailableHumanP15531 details
Protein disulfide-isomeraseProteinunknownNot AvailableHumanP07237 details
Protein disulfide-isomerase A3ProteinunknownNot AvailableHumanP30101 details
Peroxiredoxin-1ProteinunknownNot AvailableHumanQ06830 details
Phosphoserine phosphataseProteinunknownNot AvailableHumanP78330 details
Triosephosphate isomeraseProteinunknownNot AvailableHumanP60174 details
Elongation factor Tu, mitochondrialProteinunknownNot AvailableHumanP49411 details
Estrogen receptor alphaProteinunknown
cofactor
HumanP03372 details
Interleukin-3ProteinunknownNot AvailableHumanP08700 details
Metallothionein-2ProteinunknownNot AvailableHumanP02795 details
Copper chaperone for superoxide dismutaseProteinunknownNot AvailableHumanO14618 details
Histone deacetylase 1Proteinunknown
cofactor
HumanQ13547 details
Histone deacetylase 4Proteinunknown
cofactor
HumanP56524 details
DNA-3-methyladenine glycosylaseProteinunknownNot AvailableHumanP29372 details
Semenogelin-1ProteinunknownNot AvailableHumanP04279 details
Superoxide dismutase [Cu-Zn]ProteinunknownNot AvailableHumanP00441 details
Histone deacetylase 8Proteinunknown
cofactor
HumanQ9BY41 details
Apoptosis regulatory protein SivaProteinunknownNot AvailableHumanO15304 details
Glycine receptor subunit alpha-1ProteinunknownNot AvailableHumanP23415 details
E3 ubiquitin-protein ligase Mdm2ProteinunknownNot AvailableHumanQ00987 details
InsulinProteinunknownNot AvailableHumanP01308 details
UtrophinProteinunknownNot AvailableHumanP46939 details
AspartoacylaseProteinunknown
cofactor
HumanP45381 details
Protein S100-A8ProteinunknownNot AvailableHumanP05109 details
Protein S100-A9ProteinunknownNot AvailableHumanP06702 details
Matrix metalloproteinase-9ProteinunknownNot AvailableHumanP14780 details
Tumor protein p73Proteinunknown
cofactor
HumanO15350 details
Protein S100-A2ProteinunknownNot AvailableHumanP29034 details
Cellular tumor antigen p53ProteinunknownNot AvailableHumanP04637 details
Metallothionein-3ProteinunknownNot AvailableHumanP25713 details
Programmed cell death protein 6ProteinunknownNot AvailableHumanO75340 details
DAN domain family member 5Proteinunknown
cofactor
HumanQ8N907 details
Metallothionein-1AProteinunknownNot AvailableHumanP04731 details
Alpha-1B-glycoproteinProteinunknownNot AvailableHumanP04217 details
Alpha-2-macroglobulinProteinunknownNot AvailableHumanP01023 details
AngiotensinogenProteinunknownNot AvailableHumanP01019 details
Alpha-2-HS-glycoproteinProteinunknownNot AvailableHumanP02765 details
Serum amyloid P-componentProteinunknownNot AvailableHumanP02743 details
Apolipoprotein A-IProteinunknownNot AvailableHumanP02647 details
Apolipoprotein A-IIProteinunknownNot AvailableHumanP02652 details
Apolipoprotein A-IVProteinunknownNot AvailableHumanP06727 details
Apolipoprotein B receptorProteinunknownNot AvailableHumanQ0VD83 details
Apolipoprotein EProteinunknownNot AvailableHumanP02649 details
Apolipoprotein L1ProteinunknownNot AvailableHumanO14791 details
Complement C1q subcomponent subunit BProteinunknownNot AvailableHumanP02746 details
Complement C1q subcomponent subunit CProteinunknownNot AvailableHumanP02747 details
Complement C1r subcomponentProteinunknownNot AvailableHumanP00736 details
Complement C1s subcomponentProteinunknownNot AvailableHumanP09871 details
Complement C3ProteinunknownNot AvailableHumanP01024 details
Complement C4-BProteinunknownNot AvailableHumanP0C0L5 details
C4b-binding protein alpha chainProteinunknownNot AvailableHumanP04003 details
C4b-binding protein beta chainProteinunknownNot AvailableHumanP20851 details
Complement C5ProteinunknownNot AvailableHumanP01031 details
Lys-63-specific deubiquitinase BRCC36ProteinunknownNot AvailableHumanP46736 details
Complement component C8 alpha chainProteinunknownNot AvailableHumanP07357 details
Complement component C8 beta chainProteinunknownNot AvailableHumanP07358 details
Complement component C8 gamma chainProteinunknownNot AvailableHumanP07360 details
Complement factor BProteinunknownNot AvailableHumanP00751 details
Complement factor HProteinunknownNot AvailableHumanP08603 details
Complement factor IProteinunknownNot AvailableHumanP05156 details
ClusterinProteinunknownNot AvailableHumanP10909 details
CeruloplasminProteinunknownNot AvailableHumanP00450 details
Carboxypeptidase N catalytic chainProteinunknownNot AvailableHumanP15169 details
Carboxypeptidase N subunit 2ProteinunknownNot AvailableHumanP22792 details
DermcidinProteinunknownNot AvailableHumanP81605 details
DesmoplakinProteinunknownNot AvailableHumanP15924 details
Coagulation factor XIIProteinunknownNot AvailableHumanP00748 details
Coagulation factor XIII B chainProteinunknownNot AvailableHumanP05160 details
ProthrombinProteinunknownNot AvailableHumanP00734 details
Ficolin-3ProteinunknownNot AvailableHumanO75636 details
Fibrinogen alpha chainProteinunknownNot AvailableHumanP02671 details
FibronectinProteinunknownNot AvailableHumanP02751 details
GelsolinProteinunknownNot AvailableHumanP06396 details
Hemoglobin subunit alphaProteinunknownNot AvailableHumanP69905 details
Hemoglobin subunit betaProteinunknownNot AvailableHumanP68871 details
Haptoglobin-related proteinProteinunknownNot AvailableHumanP00739 details
HornerinProteinunknownNot AvailableHumanQ86YZ3 details
Insulin-like growth factor-binding protein complex acid labile subunitProteinunknownNot AvailableHumanP35858 details
Ig alpha-1 chain C regionProteinunknownNot AvailableHumanP01876 details
Ig mu chain C regionProteinunknownNot AvailableHumanP01871 details
Immunoglobulin kappa variable 1-17ProteinunknownNot AvailableHumanP01599 details
Ig kappa chain V-III region GOLProteinunknownNot AvailableHumanP01619 details
Immunoglobulin lambda variable 3-21ProteinunknownNot AvailableHumanP80748 details
Inter-alpha-trypsin inhibitor heavy chain H1ProteinunknownNot AvailableHumanP19827 details
Inter-alpha-trypsin inhibitor heavy chain H2ProteinunknownNot AvailableHumanP19823 details
Inter-alpha-trypsin inhibitor heavy chain H3ProteinunknownNot AvailableHumanQ06033 details
Inter-alpha-trypsin inhibitor heavy chain H4ProteinunknownNot AvailableHumanQ14624 details
Immunoglobulin J chainProteinunknownNot AvailableHumanP01591 details
Junction plakoglobinProteinunknownNot AvailableHumanP14923 details
Plasma kallikreinProteinunknownNot AvailableHumanP03952 details
Kininogen-1ProteinunknownNot AvailableHumanP01042 details
Keratin, type II cytoskeletal 1ProteinunknownNot AvailableHumanP04264 details
Keratin, type I cytoskeletal 10ProteinunknownNot AvailableHumanP13645 details
Keratin, type I cytoskeletal 14ProteinunknownNot AvailableHumanP02533 details
Keratin, type I cytoskeletal 16ProteinunknownNot AvailableHumanP08779 details
Keratin, type II cytoskeletal 2 epidermalProteinunknownNot AvailableHumanP35908 details
Keratin, type II cytoskeletal 5ProteinunknownNot AvailableHumanP13647 details
Keratin, type II cytoskeletal 6AProteinunknownNot AvailableHumanP02538 details
Keratin, type I cytoskeletal 9ProteinunknownNot AvailableHumanP35527 details
Alpha-1-acid glycoprotein 2ProteinunknownNot AvailableHumanP19652 details
N-acetylmuramoyl-L-alanine amidaseProteinunknownNot AvailableHumanQ96PD5 details
Serum paraoxonase/arylesterase 1ProteinunknownNot AvailableHumanP27169 details
Pregnancy zone proteinProteinunknownNot AvailableHumanP20742 details
Protein S100-A7ProteinunknownNot AvailableHumanP31151 details
Selenoprotein PProteinunknownNot AvailableHumanP49908 details
Alpha-1-antitrypsinProteinunknownNot AvailableHumanP01009 details
Alpha-1-antichymotrypsinProteinunknownNot AvailableHumanP01011 details
KallistatinProteinunknownNot AvailableHumanP29622 details
Corticosteroid-binding globulinProteinunknownNot AvailableHumanP08185 details
Heparin cofactor 2ProteinunknownNot AvailableHumanP05546 details
Sex hormone-binding globulinProteinunknownNot AvailableHumanP04278 details
SerotransferrinProteinunknownNot AvailableHumanP02787 details
TransthyretinProteinunknownNot AvailableHumanP02766 details
VitronectinProteinunknownNot AvailableHumanP04004 details
Amyloid-like protein 1Proteinunknown
cofactor
HumanP51693 details
Amyloid-like protein 2Proteinunknown
cofactor
HumanQ06481 details
Amyloid beta A4 proteinProteinunknown
cofactor
HumanP05067 details
Poly [ADP-ribose] polymerase 1ProteinunknownNot AvailableHumanP09874 details
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
Pathways
PathwayCategorySMPDB ID
Pterine BiosynthesisMetabolicSMP00005
Tyrosine MetabolismMetabolicSMP00006
Histidine MetabolismMetabolicSMP00044
2-Hydroxyglutric Aciduria (D And L Form)DiseaseSMP00136
Cilazapril Action PathwayDrug actionSMP00147
Fosinopril Action PathwayDrug actionSMP00149
Moexipril Action PathwayDrug actionSMP00151
AICA-RibosiduriaDiseaseSMP00168
Leigh SyndromeDiseaseSMP00196
MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)DiseaseSMP00202
Famotidine Action PathwayDrug actionSMP00231
4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase DeficiencyDiseaseSMP00243
Dipyridamole (Antiplatelet) Action PathwayDrug actionSMP00264
Glutathione Synthetase DeficiencyDiseaseSMP00337
Hyperinsulinism-Hyperammonemia SyndromeDiseaseSMP00339
Metachromatic Leukodystrophy (MLD)DiseaseSMP00347
GABA-Transaminase DeficiencyDiseaseSMP00351
Mercaptopurine Action PathwayDrug actionSMP00428
Thioguanine Action PathwayDrug actionSMP00430
Hyperglycinemia, non-ketoticDiseaseSMP00485
Segawa syndromeDiseaseSMP00490
Ureidopropionase deficiencyDiseaseSMP00492
Tyrosinemia, transient, of the newbornDiseaseSMP00494
5-oxoprolinase deficiencyDiseaseSMP00500
Xanthinuria type IDiseaseSMP00512
Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation typeDiseaseSMP00570
Fosinopril Metabolism PathwayDrug metabolismSMP00594
Lornoxicam Action PathwayDrug actionSMP00700
Phenylbutazone Action PathwayDrug actionSMP00701
Salsalate Action PathwayDrug actionSMP00707
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions Not Available
Food InteractionsNot Available
References
Synthesis Reference

Robert Nicaise, "Production of zinc powder for electrochemical batteries." U.S. Patent US4104188, issued 1877.

US4104188
General ReferencesNot Available
External Links
ATC CodesA16AX05 — Zinc acetateB05XA12 — Zinc chloride
AHFS Codes
  • 40:12.00
  • 84:24.12
  • 84:80.00
  • 84:92.00
  • 88:29.00*
  • 92:02.00*
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (71.7 KB)
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedNot AvailableHealthy Volunteers2
1CompletedNot AvailableZinc Deficiency1
1CompletedTreatmentAge Related Macular Degeneration (ARMD) / Neovascular Maculopathy1
1CompletedTreatmentAutism, Early Infantile / Pervasive Developmental Disorder NOS1
1CompletedTreatmentDiarrhea / Hospitalization1
1CompletedTreatmentHeart Failure, Unspecified / Prophylaxis of cardiomyopathy1
1CompletedTreatmentMajor Depressive Disorder (MDD)1
1RecruitingTreatmentMultiple Myeloma (MM)1
1RecruitingTreatmentPompe's Disease1
1RecruitingTreatmentTransplantation, Liver1
1TerminatedNot AvailableHealthy Male Volunteers1
1TerminatedBasic ScienceDrug Metabolism, Poor, CYP2D6-RELATED1
1, 2CompletedTreatmentAmyotrophic Lateral Sclerosis (ALS)1
1, 2CompletedTreatmentKidney Diseases / Transplantation, Kidney1
1, 2CompletedTreatmentLeukemia, Acute Lymphocytic (ALL) / Leukemia, Acute Myelogenous (AML) / Leukemia, Chronic Myelogenous (CML) / Myelodysplastic Syndromes (MDS) / Non-Hodgkin's Lymphoma (NHL)1
1, 2RecruitingTreatmentAdult Living Donor Kidney Transplant Recipients / Living Kidney Donors / Transplant, Kidney1
1, 2RecruitingTreatmentLiver Transplant Recipients / Living Donor (of the Respective Liver Transplant Recipient)1
1, 2RecruitingTreatmentLung Cancers1
1, 2RecruitingTreatmentPostpartum Anemia1
1, 2Unknown StatusTreatmentFemale Pattern Alopecia1
2Active Not RecruitingTreatmentAdvanced Stage Diffuse Large B-Cell Non-Hodgkin's Lymphoma / Non-Hodgkin's Lymphoma (NHL)1
2Active Not RecruitingTreatmentMultiple Myeloma (MM)1
2Active Not RecruitingTreatmentNephritis, Lupus1
2Active Not RecruitingTreatmentRenal Cancers1
2CompletedNot AvailableCancers / Tumors, Solid1
2CompletedTreatmentAcute Cerebrovascular Accidents / Edema of the cerebrum1
2CompletedTreatmentCancer, Breast1
2CompletedTreatmentCentral Serous Chorioretinopathy (CSC)1
2CompletedTreatmentChronic Idiopathic Urticaria1
2CompletedTreatmentDepressive State1
2CompletedTreatmentEndometrial Cancers1
2CompletedTreatmentLupus Erythematosus, Systemic1
2CompletedTreatmentMalignant Lymphomas1
2CompletedTreatmentNon-Proliferative Diabetic Retinopathy / Type 2 Diabetes Mellitus1
2CompletedTreatmentRejection, Transplant1
2CompletedTreatmentRenal Cell Adenocarcinoma1
2CompletedTreatmentRestless Legs Syndrome (RLS)1
2CompletedTreatmentSquamous Cell Carcinoma of the Head and Neck (SCCHN)1
2Not Yet RecruitingTreatmentCoughing1
2RecruitingTreatmentAlcohol Dependence1
2RecruitingTreatmentCocaine-Related Disorders1
2RecruitingTreatmentPlasma Cell Myeloma1
2RecruitingTreatmentTransplant, Kidney1
2TerminatedTreatmentProstate Cancer1
2TerminatedTreatmentTransplantation, Kidney1
2, 3CompletedTreatmentInfections, Bacterial / Pneumonia / Sepsis1
2, 3CompletedTreatmentLupus Erythematosus, Systemic1
2, 3CompletedTreatmentPneumonia2
2, 3CompletedTreatmentVesicular Stomatitis1
2, 3TerminatedTreatmentLupus Erythematosus, Systemic1
3CompletedPreventionAcute Respiratory Infections1
3CompletedPreventionNutrition / Pregnancy1
3CompletedTreatmentAcute Urticaria1
3CompletedTreatmentAcute Watery Diarrhoea1
3CompletedTreatmentCholera1
3CompletedTreatmentChronic Idiopathic Urticaria1
3CompletedTreatmentDiarrhea1
3CompletedTreatmentDiarrheal Illnesses / Growth Faltering / Respiratory Illness1
3CompletedTreatmentDiarrhoea1
3CompletedTreatmentElective Caesarean Section Surgeries1
3CompletedTreatmentNephritis, Lupus1
3CompletedTreatmentPneumonia1
3CompletedTreatmentTuberculosis1
3CompletedTreatmentWison's Disease1
3RecruitingTreatmentAnxiety Disorder / Dementias / Depressive State / Psychosomatic Disorders / Schizophrenic Disorders1
3TerminatedPreventionSepsis1
3TerminatedTreatmentRespiratory Infections, Acute1
3Unknown StatusTreatmentDiarrheal Disorder1
4Active Not RecruitingSupportive CareAdjunct Anesthesia Medication / Colonoscopy1
4CompletedBasic SciencePremature Births1
4CompletedDiagnosticAsthma Bronchial1
4CompletedPreventionAcute Upper Respiratory Tract Infections / Diarrhea / Pneumonia1
4CompletedPreventionHypnotic / Specified Sedative1
4CompletedPreventionMucositis1
4CompletedTreatmentHyperemesis Gravidarum / Morning Sickness / Nausea / Pregnancy / Vomiting1
4CompletedTreatmentInfections, Bacterial1
4CompletedTreatmentMigraines1
4CompletedTreatmentMigrainous Headache / Nausea / Restlessness1
4CompletedTreatmentPregnancy1
4CompletedTreatmentWilson's Disease1
4Not Yet RecruitingTreatmentAge Related Macular Degeneration (ARMD) / Diabetic Macular Edema (DME) / Macular Edema (ME) / Retinal Vein Occlusions(RVO)2
4TerminatedTreatmentAnemias1
4TerminatedTreatmentHpv / Venereal Warts1
Not AvailableActive Not RecruitingScreeningAlcoholism1
Not AvailableCompletedNot AvailablePain, Neuropathic1
Not AvailableCompletedNot AvailableTrisiomy 21 (Down Syndrome)1
Not AvailableCompletedBasic ScienceHyperalgesia1
Not AvailableCompletedPreventionDiarrhea / Morbidity / Mortality / Pneumonia1
Not AvailableCompletedPreventionHeadaches1
Not AvailableCompletedPreventionVisceral Leishmaniasis1
Not AvailableCompletedScreeningGlaucoma1
Not AvailableCompletedTreatmentAcute Respiratory Tract Infections / Diarrhea / Pneumonia1
Not AvailableCompletedTreatmentBenign Paroxysmal Positional Vertigo (BPPV)1
Not AvailableCompletedTreatmentCystic Fibrosis (CF)1
Not AvailableCompletedTreatmentDiarrhea / Hospitalization / Mortality1
Not AvailableCompletedTreatmentDiarrhea / Low Birth Weight / Respiratory Tract Infections (RTI)1
Not AvailableCompletedTreatmentEndoscopy / Sedation therapy1
Not AvailableCompletedTreatmentHearing Loss, Noise-Induced / Tinnitus, Noise Induced / Zinc Deficiency1
Not AvailableCompletedTreatmentMalnutrition1
Not AvailableCompletedTreatmentPain1
Not AvailableCompletedTreatmentPneumonia1
Not AvailableCompletedTreatmentRenal Failure Chronic1
Not AvailableRecruitingTreatmentAlcohol-Related Disorders / Brain Injury / Chronic Diseases / Depressive State / Mild Cognitive Impairment (MCI) / Pain / Posttraumatic Stress Disorders / Quality of Life / Substance-Related Disorders / Suicidal Ideation / Wounds and Injuries1
Not AvailableSuspendedDiagnosticBulimia Nervosa (BN) / Catechol-O-methyltransferase / Dopamine / Eating Disorders / Reward1
Not AvailableTerminatedPreventionChronic Kidney Failure1
Not AvailableTerminatedTreatmentPrimary Headaches (Includes Migraines, Tension, Cluster Headaches)1
Not AvailableUnknown StatusSupportive CareEndoscopic Retrograde Cholangiopancreatography (ERCP) / Endoscopic Ultrasound (EUS)1
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
SolutionIntravenous
Powder, for suspensionTopical.001 mg/mL
SprayTopical
CreamTopical1 g/50g
CreamTopical15 g/150g
CreamTopical.15 g/75g
Granule, effervescentOral
LotionTopical
CapsuleOral
TabletOral75 mg
TabletOral25 mg
Tablet, extended releaseOral
OintmentTopical
Gel, dentifriceDental
SprayTopical.1 g/100g
SprayTopical.531 g/118mL
LiquidTopical1 mg
SoapTopical.0025 mg/mg
WaferOral
Tablet, effervescentOral
Tablet, chewableOral
SprayOropharyngeal
CapsuleOral25 mg/1
CapsuleOral50 mg/1
Aerosol, sprayTopical
SolutionOral
SprayOral
LozengeOral5.5 mg
LozengeOral5 mg
AerosolTopical
SyrupOral
GelOral
LiquidOral
LiquidTopical
CapsuleOral5 mg
LiquidIntravenous
SolutionIntravenous1 mg
SolutionIntravenous5 mg
Spray, meteredOral
TabletOral
TabletOral25.0 mg
GelTopical
GelDental; Topical
SolutionTopical
SolutionDental1 %
LiquidDental.15 %
CapsuleOral2.5 mg
Gel, dentifriceOral
PowderOral
CreamTopical1.5 g/75g
LipstickTopical
LiquidTopical.001 mg/mL
Tablet, coatedOral
Capsule, gelatin coatedOral
Capsule, liquid filledOral
CreamTopical
LozengeOral13.3 mg
TabletOral90 mg
Injection, solutionIntravenous1 mg/mL
TabletOral10 mg
CapsuleOral50 mg
TabletOral50 mg
TabletOral15 mg
TabletOral30 mg
CapsuleOral30 mg
TabletOral1.37 mg
LiquidOral15 mg
LozengeOral9.9 mg
LozengeOral10 mg
LiquidOral5 mg
TabletOral20 mg
LozengeOral
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point (°C)419.5 °CPhysProp
boiling point (°C)908 °CPhysProp
Predicted Properties
PropertyValueSource
logP0.16ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9838
Blood Brain Barrier+0.9733
Caco-2 permeable+0.7354
P-glycoprotein substrateNon-substrate0.881
P-glycoprotein inhibitor INon-inhibitor0.9787
P-glycoprotein inhibitor IINon-inhibitor0.9858
Renal organic cation transporterNon-inhibitor0.911
CYP450 2C9 substrateNon-substrate0.8466
CYP450 2D6 substrateNon-substrate0.8259
CYP450 3A4 substrateNon-substrate0.8158
CYP450 1A2 substrateNon-inhibitor0.8584
CYP450 2C9 inhibitorNon-inhibitor0.9241
CYP450 2D6 inhibitorNon-inhibitor0.9638
CYP450 2C19 inhibitorNon-inhibitor0.9452
CYP450 3A4 inhibitorNon-inhibitor0.9834
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.882
Ames testNon AMES toxic0.9633
CarcinogenicityCarcinogens 0.6621
BiodegradationReady biodegradable0.7326
Rat acute toxicity2.0135 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9547
hERG inhibition (predictor II)Non-inhibitor0.9746
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of chemical entities known as homogeneous transition metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom.
KingdomChemical entities
Super ClassInorganic compounds
ClassHomogeneous metal compounds
Sub ClassHomogeneous transition metal compounds
Direct ParentHomogeneous transition metal compounds
Alternative ParentsNot Available
SubstituentsHomogeneous transition metal
Molecular FrameworkNot Available
External Descriptorselemental zinc (CHEBI:30185 )

Targets

Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Peptide binding
Specific Function:
This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.
Gene Name:
BDKRB1
Uniprot ID:
P46663
Uniprot Name:
B1 bradykinin receptor
Molecular Weight:
40494.29 Da
References
  1. Ignjatovic T, Tan F, Brovkovych V, Skidgel RA, Erdos EG: Novel mode of action of angiotensin I converting enzyme inhibitors: direct activation of bradykinin B1 receptor. J Biol Chem. 2002 May 10;277(19):16847-52. Epub 2002 Mar 5. [PubMed:11880373 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Methyltransferase activity
Specific Function:
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
Gene Name:
MGMT
Uniprot ID:
P16455
Uniprot Name:
Methylated-DNA--protein-cysteine methyltransferase
Molecular Weight:
21645.83 Da
References
  1. Rasimas JJ, Kanugula S, Dalessio PM, Ropson IJ, Fried MG, Pegg AE: Effects of zinc occupancy on human O6-alkylguanine-DNA alkyltransferase. Biochemistry. 2003 Feb 4;42(4):980-90. [PubMed:12549918 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Tubulin binding
Specific Function:
Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity).
Gene Name:
ALDOA
Uniprot ID:
P04075
Uniprot Name:
Fructose-bisphosphate aldolase A
Molecular Weight:
39419.675 Da
References
  1. She YM, Narindrasorasak S, Yang S, Spitale N, Roberts EA, Sarkar B: Identification of metal-binding proteins in human hepatoma lines by immobilized metal affinity chromatography and mass spectrometry. Mol Cell Proteomics. 2003 Dec;2(12):1306-18. Epub 2003 Oct 7. [PubMed:14534351 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Trna binding
Specific Function:
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
Gene Name:
EEF1A1
Uniprot ID:
P68104
Uniprot Name:
Elongation factor 1-alpha 1
Molecular Weight:
50140.565 Da
References
  1. She YM, Narindrasorasak S, Yang S, Spitale N, Roberts EA, Sarkar B: Identification of metal-binding proteins in human hepatoma lines by immobilized metal affinity chromatography and mass spectrometry. Mol Cell Proteomics. 2003 Dec;2(12):1306-18. Epub 2003 Oct 7. [PubMed:14534351 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Transcription factor activity, sequence-specific dna binding
Specific Function:
Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates i...
Gene Name:
ENO1
Uniprot ID:
P06733
Uniprot Name:
Alpha-enolase
Molecular Weight:
47168.555 Da
References
  1. She YM, Narindrasorasak S, Yang S, Spitale N, Roberts EA, Sarkar B: Identification of metal-binding proteins in human hepatoma lines by immobilized metal affinity chromatography and mass spectrometry. Mol Cell Proteomics. 2003 Dec;2(12):1306-18. Epub 2003 Oct 7. [PubMed:14534351 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Nadp binding
Specific Function:
May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity).
Gene Name:
GAPDHS
Uniprot ID:
O14556
Uniprot Name:
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
Molecular Weight:
44500.835 Da
References
  1. She YM, Narindrasorasak S, Yang S, Spitale N, Roberts EA, Sarkar B: Identification of metal-binding proteins in human hepatoma lines by immobilized metal affinity chromatography and mass spectrometry. Mol Cell Proteomics. 2003 Dec;2(12):1306-18. Epub 2003 Oct 7. [PubMed:14534351 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Ribosomal small subunit binding
Specific Function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities....
Gene Name:
NME1
Uniprot ID:
P15531
Uniprot Name:
Nucleoside diphosphate kinase A
Molecular Weight:
17148.635 Da
References
  1. She YM, Narindrasorasak S, Yang S, Spitale N, Roberts EA, Sarkar B: Identification of metal-binding proteins in human hepatoma lines by immobilized metal affinity chromatography and mass spectrometry. Mol Cell Proteomics. 2003 Dec;2(12):1306-18. Epub 2003 Oct 7. [PubMed:14534351 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Protein heterodimerization activity
Specific Function:
This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a...
Gene Name:
P4HB
Uniprot ID:
P07237
Uniprot Name:
Protein disulfide-isomerase
Molecular Weight:
57115.795 Da
References
  1. She YM, Narindrasorasak S, Yang S, Spitale N, Roberts EA, Sarkar B: Identification of metal-binding proteins in human hepatoma lines by immobilized metal affinity chromatography and mass spectrometry. Mol Cell Proteomics. 2003 Dec;2(12):1306-18. Epub 2003 Oct 7. [PubMed:14534351 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Not Available
Specific Function:
Cysteine-type endopeptidase activity
Gene Name:
PDIA3
Uniprot ID:
P30101
Uniprot Name:
Protein disulfide-isomerase A3
Molecular Weight:
56781.84 Da
References
  1. She YM, Narindrasorasak S, Yang S, Spitale N, Roberts EA, Sarkar B: Identification of metal-binding proteins in human hepatoma lines by immobilized metal affinity chromatography and mass spectrometry. Mol Cell Proteomics. 2003 Dec;2(12):1306-18. Epub 2003 Oct 7. [PubMed:14534351 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Thioredoxin peroxidase activity
Specific Function:
Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces a...
Gene Name:
PRDX1
Uniprot ID:
Q06830
Uniprot Name:
Peroxiredoxin-1
Molecular Weight:
22110.19 Da
References
  1. She YM, Narindrasorasak S, Yang S, Spitale N, Roberts EA, Sarkar B: Identification of metal-binding proteins in human hepatoma lines by immobilized metal affinity chromatography and mass spectrometry. Mol Cell Proteomics. 2003 Dec;2(12):1306-18. Epub 2003 Oct 7. [PubMed:14534351 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Protein homodimerization activity
Specific Function:
Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates.
Gene Name:
PSPH
Uniprot ID:
P78330
Uniprot Name:
Phosphoserine phosphatase
Molecular Weight:
25007.49 Da
References
  1. She YM, Narindrasorasak S, Yang S, Spitale N, Roberts EA, Sarkar B: Identification of metal-binding proteins in human hepatoma lines by immobilized metal affinity chromatography and mass spectrometry. Mol Cell Proteomics. 2003 Dec;2(12):1306-18. Epub 2003 Oct 7. [PubMed:14534351 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Ubiquitin protein ligase binding
Specific Function:
Not Available
Gene Name:
TPI1
Uniprot ID:
P60174
Uniprot Name:
Triosephosphate isomerase
Molecular Weight:
30790.785 Da
References
  1. She YM, Narindrasorasak S, Yang S, Spitale N, Roberts EA, Sarkar B: Identification of metal-binding proteins in human hepatoma lines by immobilized metal affinity chromatography and mass spectrometry. Mol Cell Proteomics. 2003 Dec;2(12):1306-18. Epub 2003 Oct 7. [PubMed:14534351 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Translation elongation factor activity
Specific Function:
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Gene Name:
TUFM
Uniprot ID:
P49411
Uniprot Name:
Elongation factor Tu, mitochondrial
Molecular Weight:
49541.145 Da
References
  1. She YM, Narindrasorasak S, Yang S, Spitale N, Roberts EA, Sarkar B: Identification of metal-binding proteins in human hepatoma lines by immobilized metal affinity chromatography and mass spectrometry. Mol Cell Proteomics. 2003 Dec;2(12):1306-18. Epub 2003 Oct 7. [PubMed:14534351 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
cofactor
General Function:
Zinc ion binding
Specific Function:
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription fact...
Gene Name:
ESR1
Uniprot ID:
P03372
Uniprot Name:
Estrogen receptor
Molecular Weight:
66215.45 Da
References
  1. Payne JC, Rous BW, Tenderholt AL, Godwin HA: Spectroscopic determination of the binding affinity of zinc to the DNA-binding domains of nuclear hormone receptors. Biochemistry. 2003 Dec 9;42(48):14214-24. [PubMed:14640689 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Interleukin-3 receptor binding
Specific Function:
Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.
Gene Name:
IL3
Uniprot ID:
P08700
Uniprot Name:
Interleukin-3
Molecular Weight:
17232.905 Da
References
  1. Smit V, van Veelen PA, Tjaden UR, van der Greef J, Haaijman JJ: Human interleukin-3 contains a discontinuous zinc binding domain. Biochem Biophys Res Commun. 1992 Sep 16;187(2):859-66. [PubMed:1530641 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Gene Name:
MT2A
Uniprot ID:
P02795
Uniprot Name:
Metallothionein-2
Molecular Weight:
6042.05 Da
References
  1. Palumaa P, Tammiste I, Kruusel K, Kangur L, Jornvall H, Sillard R: Metal binding of metallothionein-3 versus metallothionein-2: lower affinity and higher plasticity. Biochim Biophys Acta. 2005 Mar 14;1747(2):205-11. Epub 2004 Dec 19. [PubMed:15698955 ]
  2. Yang F, Zhou M, He Z, Liu X, Sun L, Sun Y, Chen Z: High-yield expression in Escherichia coli of soluble human MT2A with native functions. Protein Expr Purif. 2007 May;53(1):186-94. Epub 2006 Dec 15. [PubMed:17224279 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
Delivers copper to copper zinc superoxide dismutase (SOD1).
Gene Name:
CCS
Uniprot ID:
O14618
Uniprot Name:
Copper chaperone for superoxide dismutase
Molecular Weight:
29040.445 Da
References
  1. Stasser JP, Eisses JF, Barry AN, Kaplan JH, Blackburn NJ: Cysteine-to-serine mutants of the human copper chaperone for superoxide dismutase reveal a copper cluster at a domain III dimer interface. Biochemistry. 2005 Mar 8;44(9):3143-52. [PubMed:15736924 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
cofactor
General Function:
Transcription regulatory region sequence-specific dna binding
Specific Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and...
Gene Name:
HDAC1
Uniprot ID:
Q13547
Uniprot Name:
Histone deacetylase 1
Molecular Weight:
55102.615 Da
References
  1. Bhuiyan MP, Kato T, Okauchi T, Nishino N, Maeda S, Nishino TG, Yoshida M: Chlamydocin analogs bearing carbonyl group as possible ligand toward zinc atom in histone deacetylases. Bioorg Med Chem. 2006 May 15;14(10):3438-46. Epub 2006 Jan 24. [PubMed:16439135 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
cofactor
General Function:
Zinc ion binding
Specific Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via...
Gene Name:
HDAC4
Uniprot ID:
P56524
Uniprot Name:
Histone deacetylase 4
Molecular Weight:
119038.875 Da
References
  1. Bhuiyan MP, Kato T, Okauchi T, Nishino N, Maeda S, Nishino TG, Yoshida M: Chlamydocin analogs bearing carbonyl group as possible ligand toward zinc atom in histone deacetylases. Bioorg Med Chem. 2006 May 15;14(10):3438-46. Epub 2006 Jan 24. [PubMed:16439135 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.
Specific Function:
Alkylbase dna n-glycosylase activity
Gene Name:
MPG
Uniprot ID:
P29372
Uniprot Name:
DNA-3-methyladenine glycosylase
Molecular Weight:
32868.365 Da
References
  1. Massiah MA, Simmons BN, Short KM, Cox TC: Solution structure of the RBCC/TRIM B-box1 domain of human MID1: B-box with a RING. J Mol Biol. 2006 Apr 28;358(2):532-45. Epub 2006 Feb 20. [PubMed:16529770 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Structural molecule activity
Specific Function:
Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA.Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteol...
Gene Name:
SEMG1
Uniprot ID:
P04279
Uniprot Name:
Semenogelin-1
Molecular Weight:
52130.885 Da
References
  1. Jonsson M, Lundwall A, Linse S, Frohm B, Malm J: Truncated semenogelin I binds zinc and is cleaved by prostate-specific antigen. J Androl. 2006 Jul-Aug;27(4):542-7. Epub 2006 Apr 1. [PubMed:16582407 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Gene Name:
SOD1
Uniprot ID:
P00441
Uniprot Name:
Superoxide dismutase [Cu-Zn]
Molecular Weight:
15935.685 Da
References
  1. Krishnan U, Son M, Rajendran B, Elliott JL: Novel mutations that enhance or repress the aggregation potential of SOD1. Mol Cell Biochem. 2006 Jul;287(1-2):201-11. Epub 2006 Apr 1. [PubMed:16583143 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
cofactor
General Function:
Transcription factor binding
Specific Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylatio...
Gene Name:
HDAC8
Uniprot ID:
Q9BY41
Uniprot Name:
Histone deacetylase 8
Molecular Weight:
41757.29 Da
References
  1. Gantt SL, Gattis SG, Fierke CA: Catalytic activity and inhibition of human histone deacetylase 8 is dependent on the identity of the active site metal ion. Biochemistry. 2006 May 16;45(19):6170-8. [PubMed:16681389 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
Gene Name:
SIVA1
Uniprot ID:
O15304
Uniprot Name:
Apoptosis regulatory protein Siva
Molecular Weight:
18694.45 Da
References
  1. Nestler M, Martin U, Hortschansky P, Saluz HP, Henke A, Munder T: The zinc containing pro-apoptotic protein siva interacts with the peroxisomal membrane protein pmp22. Mol Cell Biochem. 2006 Jul;287(1-2):147-55. Epub 2006 May 9. [PubMed:16683188 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Transmitter-gated ion channel activity
Specific Function:
The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
Gene Name:
GLRA1
Uniprot ID:
P23415
Uniprot Name:
Glycine receptor subunit alpha-1
Molecular Weight:
52623.35 Da
References
  1. Chen Z, Dillon GH, Huang R: Identification of residues critical for Cu2+-mediated inhibition of glycine alpha1 receptors. Neuropharmacology. 2006 Sep;51(4):701-8. Epub 2006 Jul 12. [PubMed:16842826 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degrad...
Gene Name:
MDM2
Uniprot ID:
Q00987
Uniprot Name:
E3 ubiquitin-protein ligase Mdm2
Molecular Weight:
55232.39 Da
References
  1. Kostic M, Matt T, Martinez-Yamout MA, Dyson HJ, Wright PE: Solution structure of the Hdm2 C2H2C4 RING, a domain critical for ubiquitination of p53. J Mol Biol. 2006 Oct 20;363(2):433-50. Epub 2006 Aug 14. [PubMed:16965791 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Protease binding
Specific Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Gene Name:
INS
Uniprot ID:
P01308
Uniprot Name:
Insulin
Molecular Weight:
11980.795 Da
References
  1. Huus K, Havelund S, Olsen HB, van de Weert M, Frokjaer S: Chemical and thermal stability of insulin: effects of zinc and ligand binding to the insulin zinc-hexamer. Pharm Res. 2006 Nov;23(11):2611-20. Epub 2006 Sep 13. [PubMed:16969698 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
May play a role in anchoring the cytoskeleton to the plasma membrane.
Gene Name:
UTRN
Uniprot ID:
P46939
Uniprot Name:
Utrophin
Molecular Weight:
394463.09 Da
References
  1. Hnia K, Zouiten D, Cantel S, Chazalette D, Hugon G, Fehrentz JA, Masmoudi A, Diment A, Bramham J, Mornet D, Winder SJ: ZZ domain of dystrophin and utrophin: topology and mapping of a beta-dystroglycan interaction site. Biochem J. 2007 Feb 1;401(3):667-77. [PubMed:17009962 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
cofactor
General Function:
Metal ion binding
Specific Function:
Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids.
Gene Name:
ASPA
Uniprot ID:
P45381
Uniprot Name:
Aspartoacylase
Molecular Weight:
35734.79 Da
References
  1. Herga S, Berrin JG, Perrier J, Puigserver A, Giardina T: Identification of the zinc binding ligands and the catalytic residue in human aspartoacylase, an enzyme involved in Canavan disease. FEBS Lett. 2006 Oct 30;580(25):5899-904. Epub 2006 Oct 2. [PubMed:17027983 ]
  2. Bitto E, Bingman CA, Wesenberg GE, McCoy JG, Phillips GN Jr: Structure of aspartoacylase, the brain enzyme impaired in Canavan disease. Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):456-61. Epub 2006 Dec 28. [PubMed:17194761 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread. The iNOS-S100A8/A9 transnitrosylase complex directs selective inflammatory stimulus-dependent S-nitrosylation of GAPDH and probably multiple targets such as ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif; S100A8 seems to contribute to S-nitrosylation site selectivity.
Specific Function:
Arachidonic acid binding
Gene Name:
S100A8
Uniprot ID:
P05109
Uniprot Name:
Protein S100-A8
Molecular Weight:
10834.43 Da
References
  1. Vogl T, Leukert N, Barczyk K, Strupat K, Roth J: Biophysical characterization of S100A8 and S100A9 in the absence and presence of bivalent cations. Biochim Biophys Acta. 2006 Nov;1763(11):1298-306. Epub 2006 Aug 25. [PubMed:17050004 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread. Has transnitrosylase activity; in oxidatively-modified low-densitity lipoprotein (LDL(ox))-induced S-nitrosylation of GAPDH on 'Cys-247' proposed to transfer the NO moiety from NOS2/iNOS to GAPDH via its own S-nitrosylated Cys-3. The iNOS-S100A8/A9 transnitrosylase complex is proposed to also direct selective inflammatory stimulus-dependent S-nitrosylation of multiple targets such as ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif.
Specific Function:
Antioxidant activity
Gene Name:
S100A9
Uniprot ID:
P06702
Uniprot Name:
Protein S100-A9
Molecular Weight:
13241.955 Da
References
  1. Vogl T, Leukert N, Barczyk K, Strupat K, Roth J: Biophysical characterization of S100A8 and S100A9 in the absence and presence of bivalent cations. Biochim Biophys Acta. 2006 Nov;1763(11):1298-306. Epub 2006 Aug 25. [PubMed:17050004 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.
Gene Name:
MMP9
Uniprot ID:
P14780
Uniprot Name:
Matrix metalloproteinase-9
Molecular Weight:
78457.51 Da
References
  1. Martens E, Leyssen A, Van Aelst I, Fiten P, Piccard H, Hu J, Descamps FJ, Van den Steen PE, Proost P, Van Damme J, Liuzzi GM, Riccio P, Polverini E, Opdenakker G: A monoclonal antibody inhibits gelatinase B/MMP-9 by selective binding to part of the catalytic domain and not to the fibronectin or zinc binding domains. Biochim Biophys Acta. 2007 Feb;1770(2):178-86. Epub 2006 Oct 26. [PubMed:17137715 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
cofactor
General Function:
Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.
Specific Function:
Chromatin binding
Gene Name:
TP73
Uniprot ID:
O15350
Uniprot Name:
Tumor protein p73
Molecular Weight:
69622.865 Da
References
  1. Lokshin M, Li Y, Gaiddon C, Prives C: p53 and p73 display common and distinct requirements for sequence specific binding to DNA. Nucleic Acids Res. 2007;35(1):340-52. Epub 2006 Dec 14. [PubMed:17170001 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Identical protein binding
Specific Function:
May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth.
Gene Name:
S100A2
Uniprot ID:
P29034
Uniprot Name:
Protein S100-A2
Molecular Weight:
11116.695 Da
References
  1. Koch M, Bhattacharya S, Kehl T, Gimona M, Vasak M, Chazin W, Heizmann CW, Kroneck PM, Fritz G: Implications on zinc binding to S100A2. Biochim Biophys Acta. 2007 Mar;1773(3):457-70. Epub 2006 Dec 19. [PubMed:17239974 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Not Available
Specific Function:
Not Available
Gene Name:
TP53
Uniprot ID:
P04637
Uniprot Name:
Cellular tumor antigen p53
Molecular Weight:
43652.79 Da
References
  1. Wang Y, Rosengarth A, Luecke H: Structure of the human p53 core domain in the absence of DNA. Acta Crystallogr D Biol Crystallogr. 2007 Mar;63(Pt 3):276-81. Epub 2007 Feb 21. [PubMed:17327663 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro.
Gene Name:
MT3
Uniprot ID:
P25713
Uniprot Name:
Metallothionein-3
Molecular Weight:
6926.855 Da
References
  1. Meloni G, Faller P, Vasak M: Redox silencing of copper in metal-linked neurodegenerative disorders: reaction of Zn7metallothionein-3 with Cu2+ ions. J Biol Chem. 2007 Jun 1;282(22):16068-78. Epub 2007 Mar 27. [PubMed:17389590 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Protein dimerization activity
Specific Function:
Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)-regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity. May inhibit KDR/VEGFR2-dependent angiogene...
Gene Name:
PDCD6
Uniprot ID:
O75340
Uniprot Name:
Programmed cell death protein 6
Molecular Weight:
21868.32 Da
References
  1. Suzuki H, Kawasaki M, Kakiuchi T, Shibata H, Wakatsuki S, Maki M: Crystallization and X-ray diffraction analysis of N-terminally truncated human ALG-2. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Nov 1;64(Pt 11):974-7. doi: 10.1107/S1744309108030297. Epub 2008 Oct 31. [PubMed:18997320 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
cofactor
General Function:
Morphogen activity
Specific Function:
Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation (By similarity).
Gene Name:
DAND5
Uniprot ID:
Q8N907
Uniprot Name:
DAN domain family member 5
Molecular Weight:
20179.56 Da
References
  1. Kothinti R, Blodgett A, Tabatabai NM, Petering DH: Zinc finger transcription factor Zn3-Sp1 reactions with Cd2+. Chem Res Toxicol. 2010 Feb 15;23(2):405-12. doi: 10.1021/tx900370u. [PubMed:20073493 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Gene Name:
MT1A
Uniprot ID:
P04731
Uniprot Name:
Metallothionein-1A
Molecular Weight:
6120.19 Da
References
  1. Sutherland DE, Willans MJ, Stillman MJ: Single domain metallothioneins: supermetalation of human MT 1a. J Am Chem Soc. 2012 Feb 15;134(6):3290-9. doi: 10.1021/ja211767m. Epub 2012 Feb 6. [PubMed:22242602 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Not Available
Specific Function:
Not Available
Gene Name:
A1BG
Uniprot ID:
P04217
Uniprot Name:
Alpha-1B-glycoprotein
Molecular Weight:
54253.0 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Tumor necrosis factor binding
Specific Function:
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight...
Gene Name:
A2M
Uniprot ID:
P01023
Uniprot Name:
Alpha-2-macroglobulin
Molecular Weight:
163289.945 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Type 2 angiotensin receptor binding
Specific Function:
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate ...
Gene Name:
AGT
Uniprot ID:
P01019
Uniprot Name:
Angiotensinogen
Molecular Weight:
53153.73 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.
Specific Function:
Cysteine-type endopeptidase inhibitor activity
Gene Name:
AHSG
Uniprot ID:
P02765
Uniprot Name:
Alpha-2-HS-glycoprotein
Molecular Weight:
39324.35 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Virion binding
Specific Function:
Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.
Gene Name:
APCS
Uniprot ID:
P02743
Uniprot Name:
Serum amyloid P-component
Molecular Weight:
25386.92 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Phospholipid transporter activity
Specific Function:
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
Gene Name:
APOA1
Uniprot ID:
P02647
Uniprot Name:
Apolipoprotein A-I
Molecular Weight:
30777.58 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Protein homodimerization activity
Specific Function:
May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
Gene Name:
APOA2
Uniprot ID:
P02652
Uniprot Name:
Apolipoprotein A-II
Molecular Weight:
11174.925 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.
Specific Function:
Antioxidant activity
Gene Name:
APOA4
Uniprot ID:
P06727
Uniprot Name:
Apolipoprotein A-IV
Molecular Weight:
45398.775 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Very-low-density lipoprotein particle receptor activity
Specific Function:
Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevate...
Gene Name:
APOBR
Uniprot ID:
Q0VD83
Uniprot Name:
Apolipoprotein B receptor
Molecular Weight:
114873.425 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Very-low-density lipoprotein particle receptor binding
Specific Function:
Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
Gene Name:
APOE
Uniprot ID:
P02649
Uniprot Name:
Apolipoprotein E
Molecular Weight:
36153.83 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.
Specific Function:
Chloride channel activity
Gene Name:
APOL1
Uniprot ID:
O14791
Uniprot Name:
Apolipoprotein L1
Molecular Weight:
43973.805 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Not Available
Specific Function:
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
Gene Name:
C1QB
Uniprot ID:
P02746
Uniprot Name:
Complement C1q subcomponent subunit B
Molecular Weight:
26721.62 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Not Available
Specific Function:
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
Gene Name:
C1QC
Uniprot ID:
P02747
Uniprot Name:
Complement C1q subcomponent subunit C
Molecular Weight:
25773.56 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Serine-type peptidase activity
Specific Function:
C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
Gene Name:
C1R
Uniprot ID:
P00736
Uniprot Name:
Complement C1r subcomponent
Molecular Weight:
80118.04 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Serine-type endopeptidase activity
Specific Function:
C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.
Gene Name:
C1S
Uniprot ID:
P09871
Uniprot Name:
Complement C1s subcomponent
Molecular Weight:
76683.905 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Receptor binding
Specific Function:
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local i...
Gene Name:
C3
Uniprot ID:
P01024
Uniprot Name:
Complement C3
Molecular Weight:
187146.73 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.
Specific Function:
Carbohydrate binding
Gene Name:
C4B
Uniprot ID:
P0C0L5
Uniprot Name:
Complement C4-B
Molecular Weight:
192749.785 Da
References
  1. Blom AM, Kask L, Ramesh B, Hillarp A: Effects of zinc on factor I cofactor activity of C4b-binding protein and factor H. Arch Biochem Biophys. 2003 Oct 15;418(2):108-18. [PubMed:14522582 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.
Specific Function:
Rna binding
Gene Name:
C4BPA
Uniprot ID:
P04003
Uniprot Name:
C4b-binding protein alpha chain
Molecular Weight:
67032.63 Da
References
  1. Blom AM, Kask L, Ramesh B, Hillarp A: Effects of zinc on factor I cofactor activity of C4b-binding protein and factor H. Arch Biochem Biophys. 2003 Oct 15;418(2):108-18. [PubMed:14522582 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S.
Specific Function:
Not Available
Gene Name:
C4BPB
Uniprot ID:
P20851
Uniprot Name:
C4b-binding protein beta chain
Molecular Weight:
28357.215 Da
References
  1. Blom AM, Kask L, Ramesh B, Hillarp A: Effects of zinc on factor I cofactor activity of C4b-binding protein and factor H. Arch Biochem Biophys. 2003 Oct 15;418(2):108-18. [PubMed:14522582 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Receptor binding
Specific Function:
Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to th...
Gene Name:
C5
Uniprot ID:
P01031
Uniprot Name:
Complement C5
Molecular Weight:
188303.705 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097). Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs) (PubMed:20656690). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:20656690, PubMed:24075985, PubMed:26344097, PubMed:26195665). Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex (PubMed:19214193). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985).
Specific Function:
Enzyme regulator activity
Gene Name:
BRCC3
Uniprot ID:
P46736
Uniprot Name:
Lys-63-specific deubiquitinase BRCC36
Molecular Weight:
36071.695 Da
References
  1. Zeqiraj E, Tian L, Piggott CA, Pillon MC, Duffy NM, Ceccarelli DF, Keszei AF, Lorenzen K, Kurinov I, Orlicky S, Gish GD, Heck AJ, Guarne A, Greenberg RA, Sicheri F: Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function. Mol Cell. 2015 Sep 17;59(6):970-83. doi: 10.1016/j.molcel.2015.07.028. Epub 2015 Sep 3. [PubMed:26344097 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.
Specific Function:
Complement binding
Gene Name:
C8A
Uniprot ID:
P07357
Uniprot Name:
Complement component C8 alpha chain
Molecular Weight:
65162.685 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
Specific Function:
Protein complex binding
Gene Name:
C8B
Uniprot ID:
P07358
Uniprot Name:
Complement component C8 beta chain
Molecular Weight:
67046.35 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Retinol binding
Specific Function:
C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.
Gene Name:
C8G
Uniprot ID:
P07360
Uniprot Name:
Complement component C8 gamma chain
Molecular Weight:
22277.285 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Serine-type endopeptidase activity
Specific Function:
Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte bla...
Gene Name:
CFB
Uniprot ID:
P00751
Uniprot Name:
Complement factor B
Molecular Weight:
85532.325 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway.
Specific Function:
Heparan sulfate proteoglycan binding
Gene Name:
CFH
Uniprot ID:
P08603
Uniprot Name:
Complement factor H
Molecular Weight:
139095.31 Da
References
  1. Nan R, Farabella I, Schumacher FF, Miller A, Gor J, Martin AC, Jones DT, Lengyel I, Perkins SJ: Zinc binding to the Tyr402 and His402 allotypes of complement factor H: possible implications for age-related macular degeneration. J Mol Biol. 2011 May 13;408(4):714-35. doi: 10.1016/j.jmb.2011.03.006. Epub 2011 Mar 17. [PubMed:21396937 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively.
Specific Function:
Metal ion binding
Gene Name:
CFI
Uniprot ID:
P05156
Uniprot Name:
Complement factor I
Molecular Weight:
65749.78 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.
Specific Function:
Chaperone binding
Gene Name:
CLU
Uniprot ID:
P10909
Uniprot Name:
Clusterin
Molecular Weight:
52494.22 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Ferroxidase activity
Specific Function:
Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pul...
Gene Name:
CP
Uniprot ID:
P00450
Uniprot Name:
Ceruloplasmin
Molecular Weight:
122204.45 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.
Gene Name:
CPN1
Uniprot ID:
P15169
Uniprot Name:
Carboxypeptidase N catalytic chain
Molecular Weight:
52285.935 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Enzyme regulator activity
Specific Function:
The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit.
Gene Name:
CPN2
Uniprot ID:
P22792
Uniprot Name:
Carboxypeptidase N subunit 2
Molecular Weight:
60556.01 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity.
Specific Function:
Peptidase activity
Gene Name:
DCD
Uniprot ID:
P81605
Uniprot Name:
Dermcidin
Molecular Weight:
11283.745 Da
References
  1. Song C, Weichbrodt C, Salnikov ES, Dynowski M, Forsberg BO, Bechinger B, Steinem C, de Groot BL, Zachariae U, Zeth K: Crystal structure and functional mechanism of a human antimicrobial membrane channel. Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4586-91. doi: 10.1073/pnas.1214739110. Epub 2013 Feb 20. [PubMed:23426625 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.
Specific Function:
Cell adhesion molecule binding
Gene Name:
DSP
Uniprot ID:
P15924
Uniprot Name:
Desmoplakin
Molecular Weight:
331771.16 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Serine-type endopeptidase activity
Specific Function:
Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa.
Gene Name:
F12
Uniprot ID:
P00748
Uniprot Name:
Coagulation factor XII
Molecular Weight:
67791.53 Da
References
  1. Rojkaer R, Schousboe I: Partial identification of the Zn2+-binding sites in factor XII and its activation derivatives. Eur J Biochem. 1997 Jul 15;247(2):491-6. [PubMed:9266689 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.
Specific Function:
Not Available
Gene Name:
F13B
Uniprot ID:
P05160
Uniprot Name:
Coagulation factor XIII B chain
Molecular Weight:
75510.1 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Thrombospondin receptor activity
Specific Function:
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.
Gene Name:
F2
Uniprot ID:
P00734
Uniprot Name:
Prothrombin
Molecular Weight:
70036.295 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota.
Specific Function:
Antigen binding
Gene Name:
FCN3
Uniprot ID:
O75636
Uniprot Name:
Ficolin-3
Molecular Weight:
32902.74 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Structural molecule activity
Specific Function:
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelializati...
Gene Name:
FGA
Uniprot ID:
P02671
Uniprot Name:
Fibrinogen alpha chain
Molecular Weight:
94972.455 Da
References
  1. Marx G: Zinc binding to fibrinogen and fibrin. Arch Biochem Biophys. 1988 Oct;266(1):285-8. [PubMed:3178229 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Protease binding
Specific Function:
Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in t...
Gene Name:
FN1
Uniprot ID:
P02751
Uniprot Name:
Fibronectin
Molecular Weight:
262623.095 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Protein domain specific binding
Specific Function:
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
Gene Name:
GSN
Uniprot ID:
P06396
Uniprot Name:
Gelsolin
Molecular Weight:
85696.935 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Oxygen transporter activity
Specific Function:
Involved in oxygen transport from the lung to the various peripheral tissues.
Gene Name:
HBA1
Uniprot ID:
P69905
Uniprot Name:
Hemoglobin subunit alpha
Molecular Weight:
15257.405 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Oxygen transporter activity
Specific Function:
Involved in oxygen transport from the lung to the various peripheral tissues.LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.Spinorphin: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulato...
Gene Name:
HBB
Uniprot ID:
P68871
Uniprot Name:
Hemoglobin subunit beta
Molecular Weight:
15998.34 Da
References
  1. Gilman JG, Brewer GJ: The oxygen-linked zinc-binding site of human haemoglobin. Biochem J. 1978 Mar 1;169(3):625-32. [PubMed:646791 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL). This HDL particle, termed trypanosome lytic factor-1 (TLF-1), mediates human innate immune protection against many species of African trypanosomes. Binds hemoglobin with high affinity and may contribute to the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron.
Specific Function:
Hemoglobin binding
Gene Name:
HPR
Uniprot ID:
P00739
Uniprot Name:
Haptoglobin-related protein
Molecular Weight:
39029.345 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Component of the epidermal cornified cell envelopes.
Specific Function:
Calcium ion binding
Gene Name:
HRNR
Uniprot ID:
Q86YZ3
Uniprot Name:
Hornerin
Molecular Weight:
282390.185 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.
Specific Function:
Insulin-like growth factor binding
Gene Name:
IGFALS
Uniprot ID:
P35858
Uniprot Name:
Insulin-like growth factor-binding protein complex acid labile subunit
Molecular Weight:
66034.13 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Antigen binding
Specific Function:
Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.
Gene Name:
IGHA1
Uniprot ID:
P01876
Uniprot Name:
Ig alpha-1 chain C region
Molecular Weight:
37654.29 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Antigen binding
Specific Function:
IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM in...
Gene Name:
IGHM
Uniprot ID:
P01871
Uniprot Name:
Ig mu chain C region
Molecular Weight:
49306.215 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
Specific Function:
Antigen binding
Gene Name:
IGKV1-17
Uniprot ID:
P01599
Uniprot Name:
Immunoglobulin kappa variable 1-17
Molecular Weight:
12778.39 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Antigen binding
Specific Function:
Not Available
Gene Name:
Not Available
Uniprot ID:
P01619
Uniprot Name:
Ig kappa chain V-III region GOL
Molecular Weight:
11830.17 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).
Specific Function:
Antigen binding
Gene Name:
IGLV3-21
Uniprot ID:
P80748
Uniprot Name:
Immunoglobulin lambda variable 3-21
Molecular Weight:
12445.65 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
Specific Function:
Calcium ion binding
Gene Name:
ITIH1
Uniprot ID:
P19827
Uniprot Name:
Inter-alpha-trypsin inhibitor heavy chain H1
Molecular Weight:
101388.49 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
Specific Function:
Endopeptidase inhibitor activity
Gene Name:
ITIH2
Uniprot ID:
P19823
Uniprot Name:
Inter-alpha-trypsin inhibitor heavy chain H2
Molecular Weight:
106462.725 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
Specific Function:
Endopeptidase inhibitor activity
Gene Name:
ITIH3
Uniprot ID:
Q06033
Uniprot Name:
Inter-alpha-trypsin inhibitor heavy chain H3
Molecular Weight:
99848.575 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration.
Specific Function:
Endopeptidase inhibitor activity
Gene Name:
ITIH4
Uniprot ID:
Q14624
Uniprot Name:
Inter-alpha-trypsin inhibitor heavy chain H4
Molecular Weight:
103356.645 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.
Specific Function:
Antigen binding
Gene Name:
JCHAIN
Uniprot ID:
P01591
Uniprot Name:
Immunoglobulin J chain
Molecular Weight:
18098.39 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).
Specific Function:
Alpha-catenin binding
Gene Name:
JUP
Uniprot ID:
P14923
Uniprot Name:
Junction plakoglobin
Molecular Weight:
81743.98 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Serine-type endopeptidase activity
Specific Function:
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
Gene Name:
KLKB1
Uniprot ID:
P03952
Uniprot Name:
Plasma kallikrein
Molecular Weight:
71369.205 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (...
Gene Name:
KNG1
Uniprot ID:
P01042
Uniprot Name:
Kininogen-1
Molecular Weight:
71956.965 Da
References
  1. Herwald H, Morgelin M, Svensson HG, Sjobring U: Zinc-dependent conformational changes in domain D5 of high molecular mass kininogen modulate contact activation. Eur J Biochem. 2001 Jan;268(2):396-404. [PubMed:11168375 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK.
Specific Function:
Carbohydrate binding
Gene Name:
KRT1
Uniprot ID:
P04264
Uniprot Name:
Keratin, type II cytoskeletal 1
Molecular Weight:
66038.505 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Not Available
Specific Function:
Structural constituent of epidermis
Gene Name:
KRT10
Uniprot ID:
P13645
Uniprot Name:
Keratin, type I cytoskeletal 10
Molecular Weight:
58826.915 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.
Specific Function:
Keratin filament binding
Gene Name:
KRT14
Uniprot ID:
P02533
Uniprot Name:
Keratin, type I cytoskeletal 14
Molecular Weight:
51561.075 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance.
Specific Function:
Structural constituent of cytoskeleton
Gene Name:
KRT16
Uniprot ID:
P08779
Uniprot Name:
Keratin, type I cytoskeletal 16
Molecular Weight:
51267.39 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization.
Specific Function:
Cytoskeletal protein binding
Gene Name:
KRT2
Uniprot ID:
P35908
Uniprot Name:
Keratin, type II cytoskeletal 2 epidermal
Molecular Weight:
65432.65 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Not Available
Specific Function:
Scaffold protein binding
Gene Name:
KRT5
Uniprot ID:
P13647
Uniprot Name:
Keratin, type II cytoskeletal 5
Molecular Weight:
62377.985 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair.
Specific Function:
Structural constituent of cytoskeleton
Gene Name:
KRT6A
Uniprot ID:
P02538
Uniprot Name:
Keratin, type II cytoskeletal 6A
Molecular Weight:
60044.525 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly.
Specific Function:
Structural constituent of cytoskeleton
Gene Name:
KRT9
Uniprot ID:
P35527
Uniprot Name:
Keratin, type I cytoskeletal 9
Molecular Weight:
62064.29 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Not Available
Specific Function:
Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Gene Name:
ORM2
Uniprot ID:
P19652
Uniprot Name:
Alpha-1-acid glycoprotein 2
Molecular Weight:
23602.43 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity.
Gene Name:
PGLYRP2
Uniprot ID:
Q96PD5
Uniprot Name:
N-acetylmuramoyl-L-alanine amidase
Molecular Weight:
62216.365 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Protein homodimerization activity
Specific Function:
Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.
Gene Name:
PON1
Uniprot ID:
P27169
Uniprot Name:
Serum paraoxonase/arylesterase 1
Molecular Weight:
39730.99 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Specific Function:
Endopeptidase inhibitor activity
Gene Name:
PZP
Uniprot ID:
P20742
Uniprot Name:
Pregnancy zone protein
Molecular Weight:
163861.765 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
Not Available
Gene Name:
S100A7
Uniprot ID:
P31151
Uniprot Name:
Protein S100-A7
Molecular Weight:
11470.87 Da
References
  1. Brodersen DE, Nyborg J, Kjeldgaard M: Zinc-binding site of an S100 protein revealed. Two crystal structures of Ca2+-bound human psoriasin (S100A7) in the Zn2+-loaded and Zn2+-free states. Biochemistry. 1999 Feb 9;38(6):1695-704. [PubMed:10026247 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Selenium binding
Specific Function:
Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis.
Gene Name:
SEPP1
Uniprot ID:
P49908
Uniprot Name:
Selenoprotein P
Molecular Weight:
43173.37 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Serine-type endopeptidase inhibitor activity
Specific Function:
Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.Short peptide from AAT: reversible chymotrypsin...
Gene Name:
SERPINA1
Uniprot ID:
P01009
Uniprot Name:
Alpha-1-antitrypsin
Molecular Weight:
46736.195 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
Specific Function:
Dna binding
Gene Name:
SERPINA3
Uniprot ID:
P01011
Uniprot Name:
Alpha-1-antichymotrypsin
Molecular Weight:
47650.36 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.
Specific Function:
Serine-type endopeptidase inhibitor activity
Gene Name:
SERPINA4
Uniprot ID:
P29622
Uniprot Name:
Kallistatin
Molecular Weight:
48541.51 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Steroid binding
Specific Function:
Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
Gene Name:
SERPINA6
Uniprot ID:
P08185
Uniprot Name:
Corticosteroid-binding globulin
Molecular Weight:
45140.49 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Serine-type endopeptidase inhibitor activity
Specific Function:
Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.
Gene Name:
SERPIND1
Uniprot ID:
P05546
Uniprot Name:
Heparin cofactor 2
Molecular Weight:
57070.16 Da
References
  1. Eckert R, Ragg H: Zinc ions promote the interaction between heparin and heparin cofactor II. FEBS Lett. 2003 Apr 24;541(1-3):121-5. [PubMed:12706831 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Androgen binding
Specific Function:
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.
Gene Name:
SHBG
Uniprot ID:
P04278
Uniprot Name:
Sex hormone-binding globulin
Molecular Weight:
43778.755 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Transferrin receptor binding
Specific Function:
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
Gene Name:
TF
Uniprot ID:
P02787
Uniprot Name:
Serotransferrin
Molecular Weight:
77063.195 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Identical protein binding
Specific Function:
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
Gene Name:
TTR
Uniprot ID:
P02766
Uniprot Name:
Transthyretin
Molecular Weight:
15886.88 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Scavenger receptor activity
Specific Function:
Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.Somatomedin-B is a growth hormone-dependent serum factor ...
Gene Name:
VTN
Uniprot ID:
P04004
Uniprot Name:
Vitronectin
Molecular Weight:
54305.135 Da
References
  1. Wang F, Chmil C, Pierce F, Ganapathy K, Gump BB, MacKenzie JA, Metchref Y, Bendinskas K: Immobilized metal affinity chromatography and human serum proteomics. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:26-33. doi: 10.1016/j.jchromb.2013.06.032. Epub 2013 Jul 5. [PubMed:23896426 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
cofactor
General Function:
May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.
Specific Function:
Alpha-2a adrenergic receptor binding
Gene Name:
APLP1
Uniprot ID:
P51693
Uniprot Name:
Amyloid-like protein 1
Molecular Weight:
72175.825 Da
References
  1. Mayer MC, Kaden D, Schauenburg L, Hancock MA, Voigt P, Roeser D, Barucker C, Than ME, Schaefer M, Multhaup G: Novel zinc-binding site in the E2 domain regulates amyloid precursor-like protein 1 (APLP1) oligomerization. J Biol Chem. 2014 Jul 4;289(27):19019-30. doi: 10.1074/jbc.M114.570382. Epub 2014 May 22. [PubMed:24855651 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
cofactor
General Function:
May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity).
Specific Function:
Dna binding
Gene Name:
APLP2
Uniprot ID:
Q06481
Uniprot Name:
Amyloid-like protein 2
Molecular Weight:
86955.2 Da
References
  1. Mayer MC, Kaden D, Schauenburg L, Hancock MA, Voigt P, Roeser D, Barucker C, Than ME, Schaefer M, Multhaup G: Novel zinc-binding site in the E2 domain regulates amyloid precursor-like protein 1 (APLP1) oligomerization. J Biol Chem. 2014 Jul 4;289(27):19019-30. doi: 10.1074/jbc.M114.570382. Epub 2014 May 22. [PubMed:24855651 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
cofactor
General Function:
Transition metal ion binding
Specific Function:
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to ap...
Gene Name:
APP
Uniprot ID:
P05067
Uniprot Name:
Amyloid beta A4 protein
Molecular Weight:
86942.715 Da
References
  1. Mayer MC, Kaden D, Schauenburg L, Hancock MA, Voigt P, Roeser D, Barucker C, Than ME, Schaefer M, Multhaup G: Novel zinc-binding site in the E2 domain regulates amyloid precursor-like protein 1 (APLP1) oligomerization. J Biol Chem. 2014 Jul 4;289(27):19019-30. doi: 10.1074/jbc.M114.570382. Epub 2014 May 22. [PubMed:24855651 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR...
Gene Name:
PARP1
Uniprot ID:
P09874
Uniprot Name:
Poly [ADP-ribose] polymerase 1
Molecular Weight:
113082.945 Da
References
  1. Bossak K, Goch W, Piatek K, Fraczyk T, Poznanski J, Bonna A, Keil C, Hartwig A, Bal W: Unusual Zn(II) Affinities of Zinc Fingers of Poly(ADP-ribose)Polymerase 1 (PARP-1) Nuclear Protein. Chem Res Toxicol. 2015 Feb 16;28(2):191-201. [PubMed:25549802 ]
Drug created on August 29, 2007 10:03 / Updated on September 01, 2017 10:41