Heat shock protein HSP 90-alpha

Details

Name
Heat shock protein HSP 90-alpha
Synonyms
  • Heat shock 86 kDa
  • HSP 86
  • HSP86
  • HSP90A
  • HSPC1
  • HSPCA
  • LAP-2
  • Lipopolysaccharide-associated protein 2
  • LPS-associated protein 2
  • Renal carcinoma antigen NY-REN-38
Gene Name
HSP90AA1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0002228|Heat shock protein HSP 90-alpha
MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIR
YESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFME
ALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPM
GRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKED
KEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRN
PDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNN
IKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKC
LELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDY
CTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKT
LVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIV
TSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVK
DLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPPLE
GDDDTSRMEEVD
Number of residues
732
Molecular Weight
84659.015
Theoretical pI
4.66
GO Classification
Functions
ATP binding / ATPase activity / GTPase binding / identical protein binding / MHC class II protein complex binding / nitric-oxide synthase regulator activity / nucleotide binding / poly(A) RNA binding / protein homodimerization activity / TPR domain binding
Processes
axon guidance / cellular response to heat / chaperone-mediated autophagy / chaperone-mediated protein complex assembly / Fc-gamma receptor signaling pathway involved in phagocytosis / G2/M transition of mitotic cell cycle / innate immune response / mitochondrial transport / mitotic cell cycle / nitric oxide metabolic process / organelle organization / positive regulation of nitric oxide biosynthetic process / protein import into mitochondrial outer membrane / protein refolding / protein unfolding / receptor-mediated endocytosis / regulation of cellular response to heat / regulation of nitric-oxide synthase activity / regulation of protein complex assembly / response to antibiotic / response to cold / response to heat / response to unfolded protein / signal transduction / small molecule metabolic process / vascular endothelial growth factor receptor signaling pathway
Components
cytoplasm / cytosol / endocytic vesicle lumen / extracellular exosome / extracellular region / lysosomal lumen / melanosome / membrane / myelin sheath / nucleoplasm / nucleus / plasma membrane / ruffle membrane
General Function
Tpr domain binding
Specific Function
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0010783|Heat shock protein HSP 90-alpha (HSP90AA1)
ATGCCCCCGTGTTCGGGCGGGGACGGCTCCACCCCTCCTGGGCCCTCCCTTCGGGACAGG
GACTGTCCCGCCCAGAGTGCTGAATACCCGCGCGACCGTCTGGATCCCCGCCCAGGAAGC
CCCTCTGAAGCCTCCTCGCCGCCGTTTCTGAGAAGCAGGGCACCTGTTAACTGGTACCAA
GAAAAGGCCCAAGTGTTTCTCTGGCATCTGATGGTGTCTGGATCCACCACTCTACTCTGT
CTCTGGAAACAGCCCTTCCACGTCTCTGCATTCCCTGTCACCGCGTCACTGGCCTTCAGA
CAGAGCCAAGGTGCAGGGCAACACCTCTACAAGGATCTGCAGCCATTTATATTGCTTAGG
CTACTGATGCCTGAGGAAACCCAGACCCAAGACCAACCGATGGAGGAGGAGGAGGTTGAG
ACGTTCGCCTTTCAGGCAGAAATTGCCCAGTTGATGTCATTGATCATCAATACTTTCTAC
TCGAACAAAGAGATCTTTCTGAGAGAGCTCATTTCAAATTCATCAGATGCATTGGACAAA
ATCCGGTATGAAAGCTTGACAGATCCCAGTAAATTAGACTCTGGGAAAGAGCTGCATATT
AACCTTATACCGAACAAACAAGATCGAACTCTCACTATTGTGGATACTGGAATTGGAATG
ACCAAGGCTGACTTGATCAATAACCTTGGTACTATCGCCAAGTCTGGGACCAAAGCGTTC
ATGGAAGCTTTGCAGGCTGGTGCAGATATCTCTATGATTGGCCAGTTCGGTGTTGGTTTT
TATTCTGCTTATTTGGTTGCTGAGAAAGTAACTGTGATCACCAAACATAACGATGATGAG
CAGTACGCTTGGGAGTCCTCAGCAGGGGGATCATTCACAGTGAGGACAGACACAGGTGAA
CCTATGGGTCGTGGAACAAAAGTTATCCTACACCTGAAAGAAGACCAAACTGAGTACTTG
GAGGAACGAAGAATAAAGGAGATTGTGAAGAAACATTCTCAGTTTATTGGATATCCCATT
ACTCTTTTTGTGGAGAAGGAACGTGATAAAGAAGTAAGCGATGATGAGGCTGAAGAAAAG
GAAGACAAAGAAGAAGAAAAAGAAAAAGAAGAGAAAGAGTCGGAAGACAAACCTGAAATT
GAAGATGTTGGTTCTGATGAGGAAGAAGAAAAGAAGGATGGTGACAAGAAGAAGAAGAAG
AAGATTAAGGAAAAGTACATCGATCAAGAAGAGCTCAACAAAACAAAGCCCATCTGGACC
AGAAATCCCGACGATATTACTAATGAGGAGTACGGAGAATTCTATAAGAGCTTGACCAAT
GACTGGGAAGATCACTTGGCAGTGAAGCATTTTTCAGTTGAAGGACAGTTGGAATTCAGA
GCCCTTCTATTTGTCCCACGACGTGCTCCTTTTGATCTGTTTGAAAACAGAAAGAAAAAG
AACAACATCAAATTGTATGTACGCAGAGTTTTCATCATGGATAACTGTGAGGAGCTAATC
CCTGAATATCTGAACTTCATTAGAGGGGTGGTAGACTCGGAGGATCTCCCTCTAAACATA
TCCCGTGAGATGTTGCAACAAAGCAAAATTTTGAAAGTTATCAGGAAGAATTTGGTCAAA
AAATGCTTAGAACTCTTTACTGAACTGGCGGAAGATAAAGAGAACTACAAGAAATTCTAT
GAGCAGTTCTCTAAAAACATAAAGCTTGGAATACACGAAGACTCTCAAAATCGGAAGAAG
CTTTCAGAGCTGTTAAGGTACTACACATCTGCCTCTGGTGATGAGATGGTTTCTCTCAAG
GACTACTGCACCAGAATGAAGGAGAACCAGAAACATATCTATTATATCACAGGTGAGACC
AAGGACCAGGTAGCTAACTCAGCCTTTGTGGAACGTCTTCGGAAACATGGCTTAGAAGTG
ATCTATATGATTGAGCCCATTGATGAGTACTGTGTCCAACAGCTGAAGGAATTTGAGGGG
AAGACTTTAGTGTCAGTCACCAAAGAAGGCCTGGAACTTCCAGAGGATGAAGAAGAGAAA
AAGAAGCAGGAAGAGAAAAAAACAAAGTTTGAGAACCTCTGCAAAATCATGAAAGACATA
TTGGAGAAAAAAGTTGAAAAGGTGGTTGTGTCAAACCGATTGGTGACATCTCCATGCTGT
ATTGTCACAAGCACATATGGCTGGACAGCAAACATGGAGAGAATCATGAAAGCTCAAGCC
CTAAGAGACAACTCAACAATGGGTTACATGGCAGCAAAGAAACACCTGGAGATAAACCCT
GACCATTCCATTATTGAGACCTTAAGGCAAAAGGCAGAGGCTGATAAGAACGACAAGTCT
GTGAAGGATCTGGTCATCTTGCTTTATGAAACTGCGCTCCTGTCTTCTGGCTTCAGTCTG
GAAGATCCCCAGACACATGCTAACAGGATCTACAGGATGATCAAACTTGGTCTGGGTATT
GATGAAGATGACCCTACTGCTGATGATACCAGTGCTGCTGTAACTGAAGAAATGCCACCC
CTTGAAGGAGATGACGACACATCACGCATGGAAGAAGTAGACTAA
Chromosome Location
14
Locus
14q32.33
External Identifiers
ResourceLink
UniProtKB IDP07900
UniProtKB Entry NameHS90A_HUMAN
GenBank Protein ID32488
GenBank Gene IDX15183
GenAtlas IDHSP90AA1
HGNC IDHGNC:5253
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00615Rifabutinapproved, investigationalnoother/unknownDetails
DB02424Geldanamycinexperimental, investigationalunknownDetails
DB028404-(1,3-Benzodioxol-5-Yl)-5-(5-Ethyl-2,4-Dihydroxyphenyl)-2h-Pyrazole-3-Carboxylic AcidexperimentalunknownDetails
DB12442AlvespimycininvestigationalyesinhibitorDetails
DB037494-(1h-Imidazol-4-Yl)-3-(5-Ethyl-2,4-Dihydroxy-Phenyl)-1h-PyrazoleexperimentalunknownDetails
DB04588N-[4-(AMINOSULFONYL)BENZYL]-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDEexperimentalunknownDetails
DB05134TanespimycininvestigationalunknownDetails
DB06070SNX-5422investigationalunknownDetails
DB06956N-(4-ACETYLPHENYL)-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDEexperimentalunknownDetails
DB069574-CHLORO-6-(4-{4-[4-(METHYLSULFONYL)BENZYL]PIPERAZIN-1-YL}-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOLexperimentalunknownDetails
DB069585-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-PIPERAZIN-1-YL-1H-PYRAZOLE-3-CARBOXAMIDEexperimentalunknownDetails
DB069615-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]isoxazole-3-carboxamideexperimentalunknownDetails
DB069645-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)ISOXAZOLE-3-CARBOXAMIDEexperimentalunknownDetails
DB069692-amino-4-[2,4-dichloro-5-(2-pyrrolidin-1-ylethoxy)phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamideexperimentalunknownDetails
DB071004-CHLORO-6-(4-PIPERAZIN-1-YL-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOLexperimentalunknownDetails
DB07317(3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-oneexperimentalunknownDetails
DB073196-(3-BROMO-2-NAPHTHYL)-1,3,5-TRIAZINE-2,4-DIAMINEexperimentalunknownDetails
DB073243-({2-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)ETHYNYL]BENZYL}AMINO)-1,3-OXAZOL-2(3H)-ONEexperimentalunknownDetails
DB07325N-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)METHYL]-3-{[(E)-(2-OXODIHYDROFURAN-3(2H)-YLIDENE)METHYL]AMINO}BENZENESULFONAMIDEexperimentalunknownDetails
DB074955-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDEexperimentalunknownDetails
DB075024-bromo-6-(6-hydroxy-1,2-benzisoxazol-3-yl)benzene-1,3-diolexperimentalunknownDetails
DB07594CCT-018159experimentalunknownDetails
DB076014-chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diolexperimentalunknownDetails
DB078778-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINEexperimentalunknownDetails
DB081944-methyl-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-amineexperimentalunknownDetails
DB08197(5E,7S)-2-amino-7-(4-fluoro-2-pyridin-3-ylphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one oximeexperimentalunknownDetails
DB040549-Butyl-8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-YlamineexperimentalunknownDetails
DB025508-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-2-Fluoro-9-Pent-4-Ylnyl-9h-Purin-6-YlamineexperimentalunknownDetails
DB030938-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-YlamineexperimentalunknownDetails
DB027549-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-AmineexperimentalunknownDetails
DB038999-Butyl-8-(4-Methoxybenzyl)-9h-Purin-6-AmineexperimentalunknownDetails
DB038099-Butyl-8-(3-Methoxybenzyl)-9h-Purin-6-AmineexperimentalunknownDetails
DB084368-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL-9H-experimentalunknownDetails
DB023599-Butyl-8-(2,5-Dimethoxy-Benzyl)-9h-Purin-6-YlamineexperimentalunknownDetails
DB035049-Butyl-8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9h-Purin-6-YlamineexperimentalunknownDetails
DB045058-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9-Pent-4-Ylnyl-9h-Purin-6-YlamineexperimentalunknownDetails
DB042548-Benzo[1,3]Dioxol-,5-Ylmethyl-9-Butyl-2-Fluoro-9h-Purin-6-YlamineexperimentalunknownDetails
DB031378-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9-Pent-9h-Purin-6-YlamineexperimentalunknownDetails
DB084424-{[(2R)-2-(2-methylphenyl)pyrrolidin-1-yl]carbonyl}benzene-1,3-diolexperimentalunknownDetails
DB084432-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triolexperimentalunknownDetails
DB085572-[(2-methoxyethyl)amino]-4-(4-oxo-1,2,3,4-tetrahydro-9H-carbazol-9-yl)benzamideexperimentalunknownDetails
DB087864-(2-methoxyethoxy)-6-methylpyrimidin-2-amineexperimentalunknownDetails
DB087874-(2,4-dichlorophenyl)-5-phenyldiazenyl-pyrimidin-2-amineexperimentalunknownDetails
DB087883,6-DIAMINO-5-CYANO-4-(4-ETHOXYPHENYL)THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDEexperimentalunknownDetails
DB087892-AMINO-4-(2,4-DICHLOROPHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDEexperimentalunknownDetails
DB00716Nedocromilapproved, investigationalunknownDetails
DB09130Copperapproved, investigationalunknownDetails
DB04216Quercetinexperimental, investigationalunknownDetails
DB09221PolaprezincexperimentalunknownagonistDetails