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Identification
NameRifabutin
Accession NumberDB00615  (APRD00094)
TypeSmall Molecule
GroupsApproved
DescriptionA broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. [PubChem]
Structure
Thumb
Synonyms
1,4-Dihydro-1-deoxy-1',4-didehydro-5'-(2-methylpropyl)-1-oxorifamycin xiv
4-Deoxo-3,4-(2-spiro(N-isobutyl-4-piperidyl)-2,5-dihydro-1H-imidazo)-rifamycin S
4-N-Isobutylspiropiperidylrifamycin S
Ansamicin
Ansamycin
Mycobutin (tn)
Rifabutin
Rifabutina
Rifabutine
Rifabutinum
External Identifiers
  • LM 427
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
MycobutinCapsule150 mg/1OralPhysicians Total Care, Inc.1995-03-15Not applicableUs
MycobutinCapsule150 mgOralPfizer Canada Inc1995-12-31Not applicableCanada
MycobutinCapsule150 mg/1OralDepartment Of State Health Services, Pharmacy Branch1992-12-23Not applicableUs
MycobutinCapsule150 mg/1OralPharmacia And Upjohn Company Llc1992-12-23Not applicableUs
RifabutinCapsule150 mg/1OralGreenstone LLC2014-04-07Not applicableUs
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
RifabutinCapsule150 mg/1OralLupin Pharmaceuticals, Inc.2014-03-26Not applicableUs
RifabutinCapsule150 mg/1OralAmerican Health Packaging2016-07-01Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AnsatipinPfizer
AnsatipineSERB
RibutinLupin
Brand mixturesNot Available
SaltsNot Available
Categories
UNII1W306TDA6S
CAS number72559-06-9
WeightAverage: 847.0047
Monoisotopic: 846.441508846
Chemical FormulaC46H62N4O11
InChI KeyATEBXHFBFRCZMA-VXTBVIBXSA-N
InChI
InChI=1S/C46H62N4O11/c1-22(2)21-50-18-16-46(17-19-50)48-34-31-32-39(54)28(8)42-33(31)43(56)45(10,61-42)59-20-15-30(58-11)25(5)41(60-29(9)51)27(7)38(53)26(6)37(52)23(3)13-12-14-24(4)44(57)47-36(40(32)55)35(34)49-46/h12-15,20,22-23,25-27,30,37-38,41,49,52-54H,16-19,21H2,1-11H3,(H,47,57)/b13-12+,20-15+,24-14-/t23-,25+,26+,27+,30-,37-,38+,41+,45-/m0/s1
IUPAC Name
(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17-trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-1'-(2-methylpropyl)-6,23,32-trioxo-8,33-dioxa-24,27,29-triazaspiro[pentacyclo[23.6.1.1⁴,⁷.0⁵,³¹.0²⁶,³⁰]tritriacontane-28,4'-piperidin]-1(31),2,4,9,19,21,25,29-octaen-13-yl acetate
SMILES
CO[[email protected]]1\C=C\O[C@@]2(C)OC3=C(C2=O)C2=C(C(O)=C3C)C(=O)C(NC(=O)\C(C)=C/C=C/[[email protected]](C)[[email protected]](O)[C@@H](C)[C@@H](O)[C@@H](C)[[email protected]](OC(C)=O)[C@@H]1C)=C1NC3(CCN(CC3)CC(C)C)N=C21
Pharmacology
IndicationFor the prevention of disseminated Mycobacterium avium complex (MAC) disease in patients with advanced HIV infection.
Structured Indications
PharmacodynamicsRifabutin is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. It is bactericidal and has a very broad spectrum of activity against most gram-positive and gram-negative organisms (including Pseudomonas aeruginosa) and specifically Mycobacterium tuberculosis. Because of rapid emergence of resistant bacteria, use is restricted to treatment of mycobacterial infections and a few other indications. Rifabutin is well absorbed when taken orally and is distributed widely in body tissues and fluids, including the CSF. It is metabolized in the liver and eliminated in bile and, to a much lesser extent, in urine, but dose adjustments are unnecessary with renal insufficiency.
Mechanism of actionRifabutin acts via the inhibition of DNA-dependent RNA polymerase in gram-positive and some gram-negative bacteria, leading to a suppression of RNA synthesis and cell death.
TargetKindPharmacological actionActionsOrganismUniProt ID
DNA-directed RNA polymerase subunit alphaProteinyes
inhibitor
Escherichia coli (strain K12)P0A7Z4 details
DNA-directed RNA polymerase subunit betaProteinyes
inhibitor
Escherichia coli (strain K12)P0A8V2 details
DNA-directed RNA polymerase subunit beta'Proteinyes
inhibitor
Escherichia coli (strain K12)P0A8T7 details
Heat shock protein HSP 90-alphaProteinno
other/unknown
HumanP07900 details
EndoplasminProteinno
other/unknown
HumanP14625 details
Related Articles
AbsorptionRifabutin is readily absorbed from the gastrointestinal tract, with an absolute bioavailability averaging 20%.
Volume of distributionNot Available
Protein binding85%
Metabolism

Hepatic. Of the five metabolites that have been identified, 25-O-desacetyl and 31-hydroxy are the most predominant. The former metabolite has an activity equal to the parent drug and contributes up to 10% to the total antimicrobial activity.

SubstrateEnzymesProduct
Rifabutin
27-O-demethylrifabutinDetails
Rifabutin
Not Available
25-O-desacetyl rifabutinDetails
Rifabutin
Not Available
31-hydroxy rifabutinDetails
Route of eliminationA mass-balance study in three healthy adult volunteers with 14C-labeled rifabutin showed that 53% of the oral dose was excreted in the urine, primarily as metabolites. About 30% of the dose is excreted in the feces.
Half life45 (± 17) hours
Clearance
  • 0.69 +/- 0.32 L/hr/kg
ToxicityLD50 = 4.8 g/kg (mouse, male)
Affected organisms
  • Enteric bacteria and other eubacteria
  • Mycobacterium tuberculosis
  • Mycobacterium leprae
  • Mycobacterium avium
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
16-BromoepiandrosteroneThe serum concentration of 16-Bromoepiandrosterone can be decreased when it is combined with Rifabutin.Investigational
19-norandrostenedioneThe serum concentration of 19-norandrostenedione can be decreased when it is combined with Rifabutin.Experimental, Illicit
2-HYDROXY-1,4-NAPHTHOQUINONEThe serum concentration of Rifabutin can be increased when it is combined with 2-HYDROXY-1,4-NAPHTHOQUINONE.Experimental
2-mercaptobenzothiazoleThe serum concentration of Rifabutin can be increased when it is combined with 2-mercaptobenzothiazole.Vet Approved
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be decreased when it is combined with Rifabutin.Experimental, Illicit
5-androstenedioneThe serum concentration of 5-androstenedione can be decreased when it is combined with Rifabutin.Experimental, Illicit
AbirateroneThe serum concentration of Abiraterone can be decreased when it is combined with Rifabutin.Approved
AcenocoumarolThe metabolism of Acenocoumarol can be increased when combined with Rifabutin.Approved
AcetaminophenThe metabolism of Acetaminophen can be increased when combined with Rifabutin.Approved
AdinazolamThe metabolism of Adinazolam can be increased when combined with Rifabutin.Approved
AlbendazoleThe metabolism of Albendazole can be increased when combined with Rifabutin.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be increased when combined with Rifabutin.Approved
AldosteroneThe serum concentration of Aldosterone can be decreased when it is combined with Rifabutin.Experimental
AlfentanilThe serum concentration of Alfentanil can be decreased when it is combined with Rifabutin.Approved, Illicit
AlfuzosinThe metabolism of Alfuzosin can be increased when combined with Rifabutin.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be increased when combined with Rifabutin.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be increased when combined with Rifabutin.Approved
AlmotriptanThe metabolism of Almotriptan can be increased when combined with Rifabutin.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be increased when combined with Rifabutin.Approved
AlosetronThe metabolism of Alosetron can be increased when combined with Rifabutin.Approved, Withdrawn
AlprazolamThe metabolism of Alprazolam can be increased when combined with Rifabutin.Approved, Illicit, Investigational
AmbrisentanThe metabolism of Ambrisentan can be increased when combined with Rifabutin.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be increased when combined with Rifabutin.Approved
AmcinonideThe serum concentration of Amcinonide can be decreased when it is combined with Rifabutin.Approved
AminophenazoneThe metabolism of Aminophenazone can be increased when combined with Rifabutin.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be increased when combined with Rifabutin.Approved
AmiodaroneThe metabolism of Amiodarone can be increased when combined with Rifabutin.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be increased when combined with Rifabutin.Approved
AmlodipineThe metabolism of Amlodipine can be increased when combined with Rifabutin.Approved
AmobarbitalThe metabolism of Amobarbital can be increased when combined with Rifabutin.Approved, Illicit
AmorolfineThe serum concentration of Rifabutin can be increased when it is combined with Amorolfine.Approved
Amphotericin BThe serum concentration of Rifabutin can be increased when it is combined with Amphotericin B.Approved, Investigational
AmprenavirThe metabolism of Amprenavir can be increased when combined with Rifabutin.Approved
AmrinoneThe serum concentration of Amrinone can be decreased when it is combined with Rifabutin.Approved
AN2690The serum concentration of Rifabutin can be increased when it is combined with AN2690.Investigational
AnecortaveThe serum concentration of Anecortave can be decreased when it is combined with Rifabutin.Investigational
AnidulafunginThe serum concentration of Rifabutin can be increased when it is combined with Anidulafungin.Approved, Investigational
AntipyrineThe metabolism of Antipyrine can be increased when combined with Rifabutin.Approved
ApixabanThe serum concentration of Apixaban can be decreased when it is combined with Rifabutin.Approved
ApremilastThe serum concentration of Apremilast can be decreased when it is combined with Rifabutin.Approved, Investigational
AprepitantThe serum concentration of Rifabutin can be increased when it is combined with Aprepitant.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be increased when combined with Rifabutin.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Rifabutin.Approved, Investigational
ArtemetherThe serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with Rifabutin resulting in a loss in efficacy.Approved
AsenapineThe metabolism of Asenapine can be increased when combined with Rifabutin.Approved
AstemizoleThe metabolism of Astemizole can be increased when combined with Rifabutin.Approved, Withdrawn
AtazanavirThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Atazanavir.Approved, Investigational
AtomoxetineThe metabolism of Rifabutin can be decreased when combined with Atomoxetine.Approved
AtorvastatinThe metabolism of Atorvastatin can be increased when combined with Rifabutin.Approved
AtovaquoneThe serum concentration of Atovaquone can be decreased when it is combined with Rifabutin.Approved
AvanafilThe metabolism of Avanafil can be increased when combined with Rifabutin.Approved
AxitinibThe serum concentration of Axitinib can be decreased when it is combined with Rifabutin.Approved, Investigational
AzelastineThe metabolism of Azelastine can be increased when combined with Rifabutin.Approved
AzelnidipineThe serum concentration of Azelnidipine can be decreased when it is combined with Rifabutin.Approved
AzimilideThe serum concentration of Azimilide can be decreased when it is combined with Rifabutin.Investigational
AzithromycinThe metabolism of Azithromycin can be increased when combined with Rifabutin.Approved
Bafilomycin A1The serum concentration of Rifabutin can be increased when it is combined with Bafilomycin A1.Experimental
BanoxantroneThe metabolism of Banoxantrone can be increased when combined with Rifabutin.Investigational
BarbexacloneThe metabolism of Barbexaclone can be increased when combined with Rifabutin.Experimental
BarbitalThe metabolism of Barbital can be increased when combined with Rifabutin.Illicit
BarnidipineThe serum concentration of Barnidipine can be decreased when it is combined with Rifabutin.Approved
BcgThe therapeutic efficacy of Bcg can be decreased when used in combination with Rifabutin.Investigational
BeclomethasoneThe serum concentration of Beclomethasone can be decreased when it is combined with Rifabutin.Investigational
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be decreased when it is combined with Rifabutin.Approved, Investigational
BedaquilineThe serum concentration of Bedaquiline can be decreased when it is combined with Rifabutin.Approved
BenidipineThe serum concentration of Benidipine can be decreased when it is combined with Rifabutin.Approved
Benzoic AcidThe serum concentration of Rifabutin can be increased when it is combined with Benzoic Acid.Approved
BenzphetamineThe metabolism of Benzphetamine can be increased when combined with Rifabutin.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be increased when combined with Rifabutin.Approved
BepridilThe serum concentration of Bepridil can be decreased when it is combined with Rifabutin.Approved, Withdrawn
BetamethasoneThe serum concentration of Betamethasone can be decreased when it is combined with Rifabutin.Approved, Vet Approved
BexaroteneThe metabolism of Bexarotene can be increased when combined with Rifabutin.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be increased when combined with Rifabutin.Approved
BicalutamideThe metabolism of Bicalutamide can be increased when combined with Rifabutin.Approved
BifonazoleThe serum concentration of Rifabutin can be increased when it is combined with Bifonazole.Approved
BisoprololThe metabolism of Bisoprolol can be increased when combined with Rifabutin.Approved
BoceprevirThe serum concentration of Boceprevir can be decreased when it is combined with Rifabutin.Approved
BortezomibThe serum concentration of Bortezomib can be decreased when it is combined with Rifabutin.Approved, Investigational
BosentanThe serum concentration of Rifabutin can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be decreased when it is combined with Rifabutin.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be decreased when it is combined with Rifabutin.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be decreased when it is combined with Rifabutin.Approved
BrinzolamideThe metabolism of Brinzolamide can be increased when combined with Rifabutin.Approved
BromazepamThe metabolism of Bromazepam can be increased when combined with Rifabutin.Approved, Illicit
BromocriptineThe metabolism of Bromocriptine can be increased when combined with Rifabutin.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be increased when combined with Rifabutin.Approved
BudesonideThe metabolism of Budesonide can be increased when combined with Rifabutin.Approved
BupivacaineThe metabolism of Bupivacaine can be increased when combined with Rifabutin.Approved, Investigational
BuprenorphineThe metabolism of Buprenorphine can be increased when combined with Rifabutin.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be increased when combined with Rifabutin.Approved
BuspironeThe serum concentration of Buspirone can be decreased when it is combined with Rifabutin.Approved, Investigational
BusulfanThe metabolism of Busulfan can be increased when combined with Rifabutin.Approved, Investigational
ButenafineThe serum concentration of Rifabutin can be increased when it is combined with Butenafine.Approved
ButoconazoleThe serum concentration of Rifabutin can be increased when it is combined with Butoconazole.Approved
CabazitaxelThe metabolism of Cabazitaxel can be increased when combined with Rifabutin.Approved
CabergolineThe metabolism of Cabergoline can be increased when combined with Rifabutin.Approved
CabozantinibThe serum concentration of Cabozantinib can be decreased when it is combined with Rifabutin.Approved
CaffeineThe metabolism of Caffeine can be increased when combined with Rifabutin.Approved
CaiThe serum concentration of Cai can be decreased when it is combined with Rifabutin.Investigational
CalcitriolThe metabolism of Calcitriol can be increased when combined with Rifabutin.Approved, Nutraceutical
CanagliflozinThe metabolism of Canagliflozin can be increased when combined with Rifabutin.Approved
CandicidinThe serum concentration of Rifabutin can be increased when it is combined with Candicidin.Withdrawn
CannabidiolThe serum concentration of Cannabidiol can be decreased when it is combined with Rifabutin.Approved, Investigational
CarbamazepineThe metabolism of Rifabutin can be increased when combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be increased when combined with Rifabutin.Approved
CarbomycinThe metabolism of Rifabutin can be decreased when combined with Carbomycin.Vet Approved
CariprazineThe metabolism of Cariprazine can be increased when combined with Rifabutin.Approved
CarvedilolThe metabolism of Carvedilol can be increased when combined with Rifabutin.Approved, Investigational
CaspofunginThe serum concentration of Rifabutin can be increased when it is combined with Caspofungin.Approved
CelecoxibThe metabolism of Celecoxib can be increased when combined with Rifabutin.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be increased when combined with Rifabutin.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be increased when combined with Rifabutin.Approved, Vet Approved
CeritinibThe serum concentration of Ceritinib can be decreased when it is combined with Rifabutin.Approved
CerivastatinThe metabolism of Cerivastatin can be increased when combined with Rifabutin.Withdrawn
CeruleninThe serum concentration of Rifabutin can be increased when it is combined with Cerulenin.Approved
CevimelineThe metabolism of Cevimeline can be increased when combined with Rifabutin.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be increased when combined with Rifabutin.Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be increased when combined with Rifabutin.Approved, Illicit
ChloroquineThe metabolism of Chloroquine can be increased when combined with Rifabutin.Approved, Vet Approved
ChlorotrianiseneThe serum concentration of Chlorotrianisene can be decreased when it is combined with Rifabutin.Withdrawn
ChloroxineThe serum concentration of Rifabutin can be increased when it is combined with Chloroxine.Approved
ChlorphenamineThe metabolism of Chlorphenamine can be increased when combined with Rifabutin.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be increased when combined with Rifabutin.Approved, Vet Approved
ChlorzoxazoneThe metabolism of Chlorzoxazone can be increased when combined with Rifabutin.Approved
CholecalciferolThe metabolism of Cholecalciferol can be increased when combined with Rifabutin.Approved, Nutraceutical
CiclesonideThe metabolism of Ciclesonide can be increased when combined with Rifabutin.Approved, Investigational
CiclopiroxThe serum concentration of Rifabutin can be increased when it is combined with Ciclopirox.Approved, Investigational
CilnidipineThe serum concentration of Cilnidipine can be decreased when it is combined with Rifabutin.Approved
CilostazolThe metabolism of Cilostazol can be increased when combined with Rifabutin.Approved
CinacalcetThe metabolism of Cinacalcet can be increased when combined with Rifabutin.Approved
CinnarizineThe serum concentration of Cinnarizine can be decreased when it is combined with Rifabutin.Approved
CisaprideThe metabolism of Cisapride can be increased when combined with Rifabutin.Approved, Investigational, Withdrawn
CitalopramThe metabolism of Citalopram can be increased when combined with Rifabutin.Approved
ClarithromycinThe serum concentration of the active metabolites of Clarithromycin can be increased when Clarithromycin is used in combination with Rifabutin.Approved
ClemastineThe metabolism of Rifabutin can be decreased when combined with Clemastine.Approved
ClevidipineThe serum concentration of Clevidipine can be decreased when it is combined with Rifabutin.Approved
ClindamycinThe metabolism of Clindamycin can be increased when combined with Rifabutin.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be increased when combined with Rifabutin.Approved, Illicit
ClobetasolThe serum concentration of Clobetasol can be decreased when it is combined with Rifabutin.Investigational
Clobetasol propionateThe serum concentration of Clobetasol propionate can be decreased when it is combined with Rifabutin.Approved
ClocortoloneThe serum concentration of Clocortolone can be decreased when it is combined with Rifabutin.Approved
ClofazimineThe metabolism of Clofazimine can be increased when combined with Rifabutin.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be increased when combined with Rifabutin.Approved
clomethiazoleThe metabolism of clomethiazole can be increased when combined with Rifabutin.Investigational
ClomipramineThe metabolism of Clomipramine can be increased when combined with Rifabutin.Approved, Vet Approved
ClonazepamThe metabolism of Clonazepam can be increased when combined with Rifabutin.Approved, Illicit
ClonidineThe metabolism of Clonidine can be increased when combined with Rifabutin.Approved
ClopidogrelThe risk or severity of adverse effects can be increased when Rifabutin is combined with Clopidogrel.Approved, Nutraceutical
ClorazepateThe metabolism of Clorazepate can be increased when combined with Rifabutin.Approved, Illicit
ClotiazepamThe metabolism of Clotiazepam can be increased when combined with Rifabutin.Approved, Illicit
ClotrimazoleThe serum concentration of Rifabutin can be increased when it is combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be decreased when it is combined with Rifabutin.Approved
CobicistatThe metabolism of Rifabutin can be decreased when combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be decreased when it is combined with Rifabutin.Approved
CocaineThe metabolism of Cocaine can be increased when combined with Rifabutin.Approved, Illicit
CodeineThe metabolism of Codeine can be increased when combined with Rifabutin.Approved, Illicit
Coenzyme Q10The serum concentration of Coenzyme Q10 can be decreased when it is combined with Rifabutin.Experimental
ColchicineThe metabolism of Colchicine can be increased when combined with Rifabutin.Approved
ConivaptanThe serum concentration of Rifabutin can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be increased when combined with Rifabutin.Approved
CordycepinThe serum concentration of Rifabutin can be increased when it is combined with Cordycepin.Investigational
Cortisone acetateThe metabolism of Cortisone acetate can be increased when combined with Rifabutin.Approved
CrizotinibThe serum concentration of Crizotinib can be decreased when it is combined with Rifabutin.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be increased when combined with Rifabutin.Approved
CyclophosphamideThe metabolism of Cyclophosphamide can be increased when combined with Rifabutin.Approved, Investigational
CyclosporineThe metabolism of Cyclosporine can be increased when combined with Rifabutin.Approved, Investigational, Vet Approved
Cyproterone acetateThe serum concentration of Rifabutin can be decreased when it is combined with Cyproterone acetate.Approved, Investigational
CytarabineThe metabolism of Cytarabine can be increased when combined with Rifabutin.Approved, Investigational
DabrafenibThe serum concentration of Rifabutin can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe serum concentration of Daclatasvir can be decreased when it is combined with Rifabutin.Approved
DantroleneThe metabolism of Dantrolene can be increased when combined with Rifabutin.Approved
DapagliflozinThe metabolism of Dapagliflozin can be increased when combined with Rifabutin.Approved
DapsoneThe metabolism of Dapsone can be increased when combined with Rifabutin.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be increased when combined with Rifabutin.Approved, Investigational
DarodipineThe serum concentration of Darodipine can be decreased when it is combined with Rifabutin.Experimental
DarunavirThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Darunavir.Approved
DasabuvirThe metabolism of Dasabuvir can be increased when combined with Rifabutin.Approved
DasatinibThe serum concentration of Dasatinib can be decreased when it is combined with Rifabutin.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be increased when combined with Rifabutin.Approved
Decanoic AcidThe serum concentration of Rifabutin can be increased when it is combined with Decanoic Acid.Experimental
DeferasiroxThe serum concentration of Rifabutin can be decreased when it is combined with Deferasirox.Approved, Investigational
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be decreased when it is combined with Rifabutin.Investigational
DelavirdineThe metabolism of Delavirdine can be increased when combined with Rifabutin.Approved
DesogestrelThe serum concentration of Desogestrel can be decreased when it is combined with Rifabutin.Approved
DesoximetasoneThe serum concentration of Desoximetasone can be decreased when it is combined with Rifabutin.Approved
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be decreased when it is combined with Rifabutin.Approved
Desoxycorticosterone PivalateThe serum concentration of Desoxycorticosterone Pivalate can be decreased when it is combined with Rifabutin.Experimental, Vet Approved
DesvenlafaxineThe metabolism of Desvenlafaxine can be increased when combined with Rifabutin.Approved
DexamethasoneThe serum concentration of Dexamethasone can be decreased when it is combined with Rifabutin.Approved, Investigational, Vet Approved
DexamethasoneThe metabolism of Dexamethasone can be increased when combined with Rifabutin.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be decreased when it is combined with Rifabutin.Vet Approved
DextromethorphanThe metabolism of Dextromethorphan can be increased when combined with Rifabutin.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be increased when combined with Rifabutin.Approved, Illicit, Withdrawn
DiazepamThe metabolism of Diazepam can be increased when combined with Rifabutin.Approved, Illicit, Vet Approved
DiclofenacThe metabolism of Diclofenac can be increased when combined with Rifabutin.Approved, Vet Approved
DicoumarolThe metabolism of Dicoumarol can be increased when combined with Rifabutin.Approved
DienestrolThe serum concentration of Dienestrol can be decreased when it is combined with Rifabutin.Approved
DienogestThe serum concentration of Dienogest can be decreased when it is combined with Rifabutin.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Rifabutin.Approved
DiflorasoneThe serum concentration of Diflorasone can be decreased when it is combined with Rifabutin.Approved
DifluocortoloneThe serum concentration of Difluocortolone can be decreased when it is combined with Rifabutin.Approved
DifluprednateThe serum concentration of Difluprednate can be decreased when it is combined with Rifabutin.Approved
DigitoxinThe metabolism of Digitoxin can be increased when combined with Rifabutin.Approved
DigoxinThe metabolism of Digoxin can be increased when combined with Rifabutin.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be increased when combined with Rifabutin.Approved, Illicit
DihydroergotamineThe metabolism of Dihydroergotamine can be increased when combined with Rifabutin.Approved
DiltiazemThe metabolism of Diltiazem can be increased when combined with Rifabutin.Approved
DisopyramideThe metabolism of Disopyramide can be increased when combined with Rifabutin.Approved
DisulfiramThe metabolism of Disulfiram can be increased when combined with Rifabutin.Approved
DocetaxelThe metabolism of Docetaxel can be increased when combined with Rifabutin.Approved, Investigational
DofetilideThe metabolism of Dofetilide can be increased when combined with Rifabutin.Approved
DolasetronThe metabolism of Dolasetron can be increased when combined with Rifabutin.Approved
DomperidoneThe metabolism of Domperidone can be increased when combined with Rifabutin.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be increased when combined with Rifabutin.Approved
DorzolamideThe metabolism of Dorzolamide can be increased when combined with Rifabutin.Approved
DotarizineThe serum concentration of Dotarizine can be decreased when it is combined with Rifabutin.Investigational
DoxepinThe metabolism of Doxepin can be increased when combined with Rifabutin.Approved
DoxorubicinThe serum concentration of Doxorubicin can be decreased when it is combined with Rifabutin.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be increased when combined with Rifabutin.Approved, Investigational
DoxycyclineThe metabolism of Rifabutin can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be decreased when it is combined with Rifabutin.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be decreased when it is combined with Rifabutin.Approved
DrospirenoneThe serum concentration of Drospirenone can be decreased when it is combined with Rifabutin.Approved
DutasterideThe metabolism of Dutasteride can be increased when combined with Rifabutin.Approved, Investigational
EconazoleThe serum concentration of Rifabutin can be increased when it is combined with Econazole.Approved
EfavirenzThe serum concentration of Rifabutin can be decreased when it is combined with Efavirenz.Approved, Investigational
EfinaconazoleThe serum concentration of Rifabutin can be increased when it is combined with Efinaconazole.Approved
EfonidipineThe serum concentration of Efonidipine can be decreased when it is combined with Rifabutin.Approved
EletriptanThe metabolism of Eletriptan can be increased when combined with Rifabutin.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be decreased when it is combined with Rifabutin.Approved
ElvitegravirThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Elvitegravir.Approved
EnalaprilThe metabolism of Enalapril can be increased when combined with Rifabutin.Approved, Vet Approved
EnzalutamideThe serum concentration of Enzalutamide can be decreased when it is combined with Rifabutin.Approved
EperisoneThe serum concentration of Eperisone can be decreased when it is combined with Rifabutin.Approved, Investigational
EpinastineThe metabolism of Epinastine can be increased when combined with Rifabutin.Approved, Investigational
EplerenoneThe metabolism of Eplerenone can be increased when combined with Rifabutin.Approved
EquileninThe serum concentration of Equilenin can be decreased when it is combined with Rifabutin.Experimental
EquilinThe serum concentration of Equilin can be decreased when it is combined with Rifabutin.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be increased when combined with Rifabutin.Approved, Nutraceutical
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be increased when combined with Rifabutin.Approved
ErgonovineThe metabolism of Ergonovine can be increased when combined with Rifabutin.Approved
ErgotamineThe metabolism of Ergotamine can be increased when combined with Rifabutin.Approved
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Rifabutin.Approved, Investigational
ErythromycinThe metabolism of Erythromycin can be increased when combined with Rifabutin.Approved, Vet Approved
EscitalopramThe metabolism of Escitalopram can be increased when combined with Rifabutin.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Rifabutin can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsomeprazoleThe metabolism of Esomeprazole can be increased when combined with Rifabutin.Approved, Investigational
EstazolamThe metabolism of Estazolam can be increased when combined with Rifabutin.Approved, Illicit
EstradiolThe metabolism of Estradiol can be increased when combined with Rifabutin.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be increased when combined with Rifabutin.Approved
EstramustineThe metabolism of Estramustine can be increased when combined with Rifabutin.Approved
Estrogens, esterifiedThe serum concentration of Estrogens, esterified can be decreased when it is combined with Rifabutin.Approved
EstroneThe metabolism of Estrone can be increased when combined with Rifabutin.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be increased when combined with Rifabutin.Approved
EszopicloneThe metabolism of Eszopiclone can be increased when combined with Rifabutin.Approved
EthanolThe metabolism of Ethanol can be increased when combined with Rifabutin.Approved
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be increased when combined with Rifabutin.Approved
EthosuximideThe metabolism of Ethosuximide can be increased when combined with Rifabutin.Approved
Ethyl biscoumacetateThe metabolism of Ethyl biscoumacetate can be increased when combined with Rifabutin.Withdrawn
EthylmorphineThe metabolism of Ethylmorphine can be increased when combined with Rifabutin.Approved, Illicit
Ethynodiol diacetateThe serum concentration of Ethynodiol diacetate can be decreased when it is combined with Rifabutin.Approved
EtonogestrelThe metabolism of Etonogestrel can be increased when combined with Rifabutin.Approved, Investigational
EtoposideThe serum concentration of Etoposide can be decreased when it is combined with Rifabutin.Approved
EtoricoxibThe metabolism of Etoricoxib can be increased when combined with Rifabutin.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Rifabutin.Approved
EverolimusThe serum concentration of Everolimus can be decreased when it is combined with Rifabutin.Approved
ExemestaneThe serum concentration of Exemestane can be decreased when it is combined with Rifabutin.Approved, Investigational
FamciclovirThe metabolism of Famciclovir can be increased when combined with Rifabutin.Approved
FelbamateThe metabolism of Felbamate can be increased when combined with Rifabutin.Approved
FelodipineThe metabolism of Felodipine can be increased when combined with Rifabutin.Approved, Investigational
FendilineThe serum concentration of Fendiline can be decreased when it is combined with Rifabutin.Withdrawn
FenofibrateThe metabolism of Fenofibrate can be increased when combined with Rifabutin.Approved
FentanylThe serum concentration of Fentanyl can be decreased when it is combined with Rifabutin.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe metabolism of Fesoterodine can be increased when combined with Rifabutin.Approved
FinasterideThe metabolism of Finasteride can be increased when combined with Rifabutin.Approved
FingolimodThe metabolism of Fingolimod can be increased when combined with Rifabutin.Approved, Investigational
FlibanserinThe serum concentration of Flibanserin can be decreased when it is combined with Rifabutin.Approved
fluasteroneThe serum concentration of fluasterone can be decreased when it is combined with Rifabutin.Investigational
FluconazoleThe serum concentration of Rifabutin can be increased when it is combined with Fluconazole.Approved
FlucytosineThe serum concentration of Rifabutin can be increased when it is combined with Flucytosine.Approved
FludrocortisoneThe serum concentration of Fludrocortisone can be decreased when it is combined with Rifabutin.Approved
FluindioneThe metabolism of Fluindione can be increased when combined with Rifabutin.Investigational
FlumethasoneThe serum concentration of Flumethasone can be decreased when it is combined with Rifabutin.Approved, Vet Approved
FlunarizineThe serum concentration of Flunarizine can be decreased when it is combined with Rifabutin.Approved
FlunisolideThe metabolism of Flunisolide can be increased when combined with Rifabutin.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be increased when combined with Rifabutin.Approved, Illicit
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be decreased when it is combined with Rifabutin.Approved, Investigational, Vet Approved
FluocinonideThe serum concentration of Fluocinonide can be decreased when it is combined with Rifabutin.Approved, Investigational
FluocortoloneThe serum concentration of Fluocortolone can be decreased when it is combined with Rifabutin.Approved, Withdrawn
FluorometholoneThe metabolism of Fluorometholone can be increased when combined with Rifabutin.Approved
FluoxetineThe metabolism of Fluoxetine can be increased when combined with Rifabutin.Approved, Vet Approved
FluprednideneThe serum concentration of Fluprednidene can be decreased when it is combined with Rifabutin.Approved, Withdrawn
FluprednisoloneThe serum concentration of Fluprednisolone can be decreased when it is combined with Rifabutin.Approved
FlurandrenolideThe serum concentration of Flurandrenolide can be decreased when it is combined with Rifabutin.Approved
FlurazepamThe metabolism of Flurazepam can be increased when combined with Rifabutin.Approved, Illicit
FlutamideThe metabolism of Flutamide can be increased when combined with Rifabutin.Approved
Fluticasone furoateThe metabolism of Fluticasone furoate can be increased when combined with Rifabutin.Approved
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be increased when combined with Rifabutin.Approved
FluvastatinThe metabolism of Fluvastatin can be increased when combined with Rifabutin.Approved
FluvoxamineThe metabolism of Rifabutin can be decreased when combined with Fluvoxamine.Approved, Investigational
FormestaneThe serum concentration of Formestane can be decreased when it is combined with Rifabutin.Approved, Investigational, Withdrawn
FosamprenavirThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Rifabutin can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe metabolism of Rifabutin can be increased when combined with Fosphenytoin.Approved
FulvestrantThe metabolism of Fulvestrant can be increased when combined with Rifabutin.Approved, Investigational
Fusidic AcidThe serum concentration of Rifabutin can be increased when it is combined with Fusidic Acid.Approved
GabapentinThe serum concentration of Gabapentin can be decreased when it is combined with Rifabutin.Approved, Investigational
GalantamineThe metabolism of Galantamine can be increased when combined with Rifabutin.Approved
GallopamilThe serum concentration of Gallopamil can be decreased when it is combined with Rifabutin.Investigational
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Rifabutin.Approved, Investigational
GemfibrozilThe metabolism of Gemfibrozil can be increased when combined with Rifabutin.Approved
GestodeneThe serum concentration of Gestodene can be decreased when it is combined with Rifabutin.Approved
GlipizideThe metabolism of Glipizide can be increased when combined with Rifabutin.Approved
GlyburideThe metabolism of Glyburide can be increased when combined with Rifabutin.Approved
GlyphosateThe serum concentration of Rifabutin can be increased when it is combined with Glyphosate.Experimental
GranisetronThe metabolism of Granisetron can be increased when combined with Rifabutin.Approved, Investigational
GrepafloxacinThe metabolism of Grepafloxacin can be increased when combined with Rifabutin.Withdrawn
GriseofulvinThe serum concentration of Rifabutin can be increased when it is combined with Griseofulvin.Approved, Vet Approved
GuanfacineThe serum concentration of Guanfacine can be decreased when it is combined with Rifabutin.Approved, Investigational
HalofantrineThe metabolism of Halofantrine can be increased when combined with Rifabutin.Approved
HaloperidolThe metabolism of Haloperidol can be increased when combined with Rifabutin.Approved
HaloproginThe serum concentration of Rifabutin can be increased when it is combined with Haloprogin.Approved, Withdrawn
HalothaneThe metabolism of Halothane can be increased when combined with Rifabutin.Approved, Vet Approved
HE3286The serum concentration of HE3286 can be decreased when it is combined with Rifabutin.Investigational
HexestrolThe serum concentration of Hexestrol can be decreased when it is combined with Rifabutin.Withdrawn
HexetidineThe serum concentration of Rifabutin can be increased when it is combined with Hexetidine.Approved
HexobarbitalThe metabolism of Hexobarbital can be increased when combined with Rifabutin.Approved
Histamine PhosphateThe metabolism of Histamine Phosphate can be increased when combined with Rifabutin.Approved
HydrocodoneThe serum concentration of Hydrocodone can be decreased when it is combined with Rifabutin.Approved, Illicit
HydrocortisoneThe metabolism of Hydrocortisone can be increased when combined with Rifabutin.Approved, Vet Approved
HydrocortisoneThe serum concentration of Hydrocortisone can be decreased when it is combined with Rifabutin.Approved, Vet Approved
HydromorphoneThe metabolism of Hydromorphone can be increased when combined with Rifabutin.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be increased when combined with Rifabutin.Approved
IbrutinibThe serum concentration of Ibrutinib can be decreased when it is combined with Rifabutin.Approved
IdelalisibThe serum concentration of Rifabutin can be increased when it is combined with Idelalisib.Approved
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be increased when Ifosfamide is used in combination with Rifabutin.Approved
IloperidoneThe metabolism of Iloperidone can be increased when combined with Rifabutin.Approved
ImatinibThe serum concentration of Imatinib can be decreased when it is combined with Rifabutin.Approved
ImipramineThe metabolism of Imipramine can be increased when combined with Rifabutin.Approved
ImiquimodThe metabolism of Imiquimod can be increased when combined with Rifabutin.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be increased when combined with Rifabutin.Approved
IndapamideThe metabolism of Indapamide can be increased when combined with Rifabutin.Approved
IndinavirThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Indinavir.Approved
Ipratropium bromideThe metabolism of Ipratropium bromide can be increased when combined with Rifabutin.Approved
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be reduced when Irinotecan is used in combination with Rifabutin resulting in a loss in efficacy.Approved, Investigational
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Rifabutin resulting in a loss in efficacy.Approved, Investigational
IsoconazoleThe serum concentration of Rifabutin can be increased when it is combined with Isoconazole.Approved
IsoniazidRifabutin may increase the hepatotoxic activities of Isoniazid.Approved
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be increased when combined with Rifabutin.Approved
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be increased when combined with Rifabutin.Approved
IsradipineThe metabolism of Isradipine can be increased when combined with Rifabutin.Approved
IstaroximeThe serum concentration of Istaroxime can be decreased when it is combined with Rifabutin.Investigational
ItraconazoleThe serum concentration of Itraconazole can be decreased when it is combined with Rifabutin.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be decreased when it is combined with Rifabutin.Approved
IvacaftorThe serum concentration of Ivacaftor can be decreased when it is combined with Rifabutin.Approved
IvermectinThe metabolism of Ivermectin can be increased when combined with Rifabutin.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be decreased when it is combined with Rifabutin.Approved, Investigational
IxazomibThe serum concentration of Ixazomib can be decreased when it is combined with Rifabutin.Approved
JosamycinThe metabolism of Rifabutin can be decreased when combined with Josamycin.Approved
KetamineThe metabolism of Ketamine can be increased when combined with Rifabutin.Approved, Vet Approved
KetazolamThe metabolism of Ketazolam can be increased when combined with Rifabutin.Approved
KetobemidoneThe metabolism of Ketobemidone can be increased when combined with Rifabutin.Approved
KetoconazoleThe metabolism of Ketoconazole can be increased when combined with Rifabutin.Approved, Investigational
KitasamycinThe metabolism of Rifabutin can be decreased when combined with Kitasamycin.Experimental
LacidipineThe serum concentration of Lacidipine can be decreased when it is combined with Rifabutin.Approved
LamotrigineThe serum concentration of Lamotrigine can be decreased when it is combined with Rifabutin.Approved, Investigational
LansoprazoleThe metabolism of Lansoprazole can be increased when combined with Rifabutin.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be decreased when it is combined with Rifabutin.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be increased when combined with Rifabutin.Investigational
LedipasvirThe serum concentration of Ledipasvir can be decreased when it is combined with Rifabutin.Approved
LenvatinibThe metabolism of Lenvatinib can be increased when combined with Rifabutin.Approved
LercanidipineThe metabolism of Lercanidipine can be increased when combined with Rifabutin.Approved, Investigational
LetrozoleThe metabolism of Letrozole can be increased when combined with Rifabutin.Approved, Investigational
LevobupivacaineThe metabolism of Levobupivacaine can be increased when combined with Rifabutin.Approved
LevocetirizineThe metabolism of Levocetirizine can be increased when combined with Rifabutin.Approved
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be increased when combined with Rifabutin.Approved
LevomilnacipranThe metabolism of Levomilnacipran can be increased when combined with Rifabutin.Approved
LevonorgestrelThe metabolism of Levonorgestrel can be increased when combined with Rifabutin.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be increased when combined with Rifabutin.Approved
LidocaineThe metabolism of Lidocaine can be increased when combined with Rifabutin.Approved, Vet Approved
LinagliptinThe serum concentration of Linagliptin can be decreased when it is combined with Rifabutin.Approved
LisurideThe metabolism of Lisuride can be increased when combined with Rifabutin.Approved
LomitapideThe metabolism of Lomitapide can be increased when combined with Rifabutin.Approved
LoperamideThe metabolism of Loperamide can be increased when combined with Rifabutin.Approved
LopinavirThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Lopinavir.Approved
LoratadineThe metabolism of Loratadine can be increased when combined with Rifabutin.Approved
LorcaserinThe metabolism of Lorcaserin can be increased when combined with Rifabutin.Approved
LosartanThe metabolism of Losartan can be increased when combined with Rifabutin.Approved
LovastatinThe metabolism of Lovastatin can be increased when combined with Rifabutin.Approved, Investigational
LuliconazoleThe serum concentration of Rifabutin can be increased when it is combined with Luliconazole.Approved
LumacaftorThe metabolism of Rifabutin can be increased when combined with Lumacaftor.Approved
LumefantrineThe serum concentration of Lumefantrine can be decreased when it is combined with Rifabutin.Approved
LurasidoneThe serum concentration of Lurasidone can be decreased when it is combined with Rifabutin.Approved
LynestrenolThe serum concentration of Lynestrenol can be decreased when it is combined with Rifabutin.Investigational
MacitentanThe serum concentration of Macitentan can be decreased when it is combined with Rifabutin.Approved
Magnesium SulfateThe serum concentration of Magnesium Sulfate can be decreased when it is combined with Rifabutin.Approved, Vet Approved
ManidipineThe serum concentration of Manidipine can be decreased when it is combined with Rifabutin.Approved
MaravirocThe serum concentration of Maraviroc can be decreased when it is combined with Rifabutin.Approved, Investigational
ME-609The serum concentration of ME-609 can be decreased when it is combined with Rifabutin.Investigational
MebendazoleThe metabolism of Mebendazole can be increased when combined with Rifabutin.Approved, Vet Approved
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be increased when combined with Rifabutin.Approved, Investigational
MedrysoneThe serum concentration of Medrysone can be decreased when it is combined with Rifabutin.Approved
MefloquineThe metabolism of Mefloquine can be increased when combined with Rifabutin.Approved
MelengestrolThe serum concentration of Melengestrol can be decreased when it is combined with Rifabutin.Vet Approved
MeloxicamThe metabolism of Meloxicam can be increased when combined with Rifabutin.Approved, Vet Approved
MestranolThe serum concentration of Mestranol can be decreased when it is combined with Rifabutin.Approved
MethadoneThe serum concentration of Methadone can be decreased when it is combined with Rifabutin.Approved
MethallenestrilThe serum concentration of Methallenestril can be decreased when it is combined with Rifabutin.Experimental
MethaqualoneThe metabolism of Methaqualone can be increased when combined with Rifabutin.Illicit, Withdrawn
MethohexitalThe metabolism of Methohexital can be increased when combined with Rifabutin.Approved
MethoxsalenThe metabolism of Methoxsalen can be increased when combined with Rifabutin.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be increased when combined with Rifabutin.Approved, Vet Approved
MethylphenobarbitalThe metabolism of Methylphenobarbital can be increased when combined with Rifabutin.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be decreased when it is combined with Rifabutin.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be increased when combined with Rifabutin.Approved
MetronidazoleThe metabolism of Metronidazole can be increased when combined with Rifabutin.Approved
MevastatinThe serum concentration of Mevastatin can be decreased when it is combined with Rifabutin.Experimental
MexiletineThe metabolism of Mexiletine can be increased when combined with Rifabutin.Approved
MianserinThe metabolism of Mianserin can be increased when combined with Rifabutin.Approved
MibefradilThe metabolism of Mibefradil can be increased when combined with Rifabutin.Withdrawn
MicafunginThe serum concentration of Rifabutin can be increased when it is combined with Micafungin.Approved, Investigational
MiconazoleThe metabolism of Miconazole can be increased when combined with Rifabutin.Approved, Investigational, Vet Approved
MidazolamThe metabolism of Midazolam can be increased when combined with Rifabutin.Approved, Illicit
MifepristoneThe serum concentration of Mifepristone can be decreased when it is combined with Rifabutin.Approved, Investigational
MiltefosineThe serum concentration of Rifabutin can be increased when it is combined with Miltefosine.Approved
MirabegronThe metabolism of Mirabegron can be increased when combined with Rifabutin.Approved
MirtazapineThe metabolism of Mirtazapine can be increased when combined with Rifabutin.Approved
MitotaneThe serum concentration of Rifabutin can be decreased when it is combined with Mitotane.Approved
ModafinilThe metabolism of Modafinil can be increased when combined with Rifabutin.Approved, Investigational
MometasoneThe serum concentration of Mometasone can be decreased when it is combined with Rifabutin.Approved, Vet Approved
MonensinThe serum concentration of Rifabutin can be increased when it is combined with Monensin.Vet Approved
MontelukastThe metabolism of Montelukast can be increased when combined with Rifabutin.Approved
MorphineThe metabolism of Morphine can be increased when combined with Rifabutin.Approved, Investigational
MorphineThe serum concentration of Morphine can be decreased when it is combined with Rifabutin.Approved, Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be increased when combined with Rifabutin.Approved, Investigational
Mycophenolic acidThe serum concentration of Mycophenolic acid can be decreased when it is combined with Rifabutin.Approved
MyxothiazolThe serum concentration of Rifabutin can be increased when it is combined with Myxothiazol.Experimental
NafcillinThe serum concentration of Rifabutin can be decreased when it is combined with Nafcillin.Approved
NaftifineThe serum concentration of Rifabutin can be increased when it is combined with Naftifine.Approved
NaftopidilThe serum concentration of Naftopidil can be decreased when it is combined with Rifabutin.Investigational
NaloxegolThe serum concentration of Naloxegol can be decreased when it is combined with Rifabutin.Approved
NaloxoneThe metabolism of Naloxone can be increased when combined with Rifabutin.Approved, Vet Approved
NatamycinThe serum concentration of Rifabutin can be increased when it is combined with Natamycin.Approved
NateglinideThe metabolism of Nateglinide can be increased when combined with Rifabutin.Approved, Investigational
NCX 1022The serum concentration of NCX 1022 can be decreased when it is combined with Rifabutin.Investigational
NefazodoneThe metabolism of Nefazodone can be increased when combined with Rifabutin.Approved, Withdrawn
NelfinavirThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Nelfinavir.Approved
NetupitantThe serum concentration of Netupitant can be decreased when it is combined with Rifabutin.Approved
NevirapineThe serum concentration of Nevirapine can be decreased when it is combined with Rifabutin.Approved
NicardipineThe metabolism of Nicardipine can be increased when combined with Rifabutin.Approved
NicotineThe metabolism of Nicotine can be increased when combined with Rifabutin.Approved
NifedipineThe serum concentration of Nifedipine can be decreased when it is combined with Rifabutin.Approved
NiguldipineThe serum concentration of Niguldipine can be decreased when it is combined with Rifabutin.Experimental
NilotinibThe serum concentration of Nilotinib can be decreased when it is combined with Rifabutin.Approved, Investigational
NiludipineThe serum concentration of Niludipine can be decreased when it is combined with Rifabutin.Experimental
NilvadipineThe metabolism of Nilvadipine can be increased when combined with Rifabutin.Approved
NimesulideThe serum concentration of Nimesulide can be decreased when it is combined with Rifabutin.Approved, Withdrawn
NimodipineThe serum concentration of Nimodipine can be decreased when it is combined with Rifabutin.Approved
NisoldipineThe serum concentration of Nisoldipine can be decreased when it is combined with Rifabutin.Approved
NitrazepamThe metabolism of Nitrazepam can be increased when combined with Rifabutin.Approved
NitrendipineThe metabolism of Nitrendipine can be increased when combined with Rifabutin.Approved
NitroxolineThe serum concentration of Rifabutin can be increased when it is combined with Nitroxoline.Approved
NorelgestrominThe serum concentration of Norelgestromin can be decreased when it is combined with Rifabutin.Approved
NorethisteroneThe metabolism of Norethisterone can be increased when combined with Rifabutin.Approved
NorgestimateThe serum concentration of Norgestimate can be decreased when it is combined with Rifabutin.Approved
NorgestrelThe metabolism of Norgestrel can be increased when combined with Rifabutin.Approved
NortriptylineThe metabolism of Nortriptyline can be increased when combined with Rifabutin.Approved
NystatinThe serum concentration of Rifabutin can be increased when it is combined with Nystatin.Approved, Vet Approved
OlaparibThe serum concentration of Olaparib can be decreased when it is combined with Rifabutin.Approved
OleandomycinThe metabolism of Rifabutin can be decreased when combined with Oleandomycin.Vet Approved
Oleoyl estroneThe serum concentration of Oleoyl estrone can be decreased when it is combined with Rifabutin.Investigational
OlopatadineThe metabolism of Olopatadine can be increased when combined with Rifabutin.Approved
OmeprazoleThe metabolism of Omeprazole can be increased when combined with Rifabutin.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be increased when combined with Rifabutin.Approved
OrphenadrineThe metabolism of Orphenadrine can be increased when combined with Rifabutin.Approved
OsimertinibThe serum concentration of Osimertinib can be decreased when it is combined with Rifabutin.Approved
OspemifeneThe metabolism of Ospemifene can be increased when combined with Rifabutin.Approved
OxazepamThe metabolism of Oxazepam can be increased when combined with Rifabutin.Approved
OxiconazoleThe serum concentration of Rifabutin can be increased when it is combined with Oxiconazole.Approved
OxybutyninThe metabolism of Oxybutynin can be increased when combined with Rifabutin.Approved, Investigational
OxycodoneThe metabolism of Oxycodone can be increased when combined with Rifabutin.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be increased when combined with Rifabutin.Approved, Investigational, Vet Approved
PaclitaxelThe metabolism of Paclitaxel can be increased when combined with Rifabutin.Approved, Vet Approved
pafuramidineThe serum concentration of Rifabutin can be increased when it is combined with pafuramidine.Investigational
PalbociclibThe serum concentration of Palbociclib can be decreased when it is combined with Rifabutin.Approved
PalonosetronThe metabolism of Palonosetron can be increased when combined with Rifabutin.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be decreased when it is combined with Rifabutin.Approved, Investigational
PantoprazoleThe metabolism of Pantoprazole can be increased when combined with Rifabutin.Approved
ParamethadioneThe metabolism of Paramethadione can be increased when combined with Rifabutin.Approved
ParamethasoneThe metabolism of Paramethasone can be increased when combined with Rifabutin.Approved
ParecoxibThe metabolism of Parecoxib can be increased when combined with Rifabutin.Approved
ParicalcitolThe metabolism of Paricalcitol can be increased when combined with Rifabutin.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be increased when combined with Rifabutin.Approved
PazopanibThe serum concentration of Pazopanib can be decreased when it is combined with Rifabutin.Approved
Peginterferon alfa-2bThe serum concentration of Rifabutin can be increased when it is combined with Peginterferon alfa-2b.Approved
PentamidineThe metabolism of Pentamidine can be increased when combined with Rifabutin.Approved
PentobarbitalThe metabolism of Rifabutin can be increased when combined with Pentobarbital.Approved, Vet Approved
PerampanelThe serum concentration of Perampanel can be decreased when it is combined with Rifabutin.Approved
PergolideThe metabolism of Pergolide can be increased when combined with Rifabutin.Approved, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be increased when combined with Rifabutin.Approved
PermethrinThe metabolism of Permethrin can be increased when combined with Rifabutin.Approved, Investigational
PerphenazineThe metabolism of Perphenazine can be increased when combined with Rifabutin.Approved
PethidineThe metabolism of Pethidine can be increased when combined with Rifabutin.Approved
PhenacetinThe metabolism of Phenacetin can be increased when combined with Rifabutin.Withdrawn
PhenindioneThe metabolism of Phenindione can be increased when combined with Rifabutin.Approved
PhenobarbitalThe metabolism of Rifabutin can be increased when combined with Phenobarbital.Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be increased when combined with Rifabutin.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be increased when combined with Rifabutin.Approved
PhenytoinThe metabolism of Rifabutin can be increased when combined with Phenytoin.Approved, Vet Approved
Picosulfuric acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Rifabutin.Approved
PilocarpineThe metabolism of Pilocarpine can be increased when combined with Rifabutin.Approved
PimecrolimusThe metabolism of Pimecrolimus can be increased when combined with Rifabutin.Approved, Investigational
PimozideThe metabolism of Pimozide can be increased when combined with Rifabutin.Approved
PinacidilThe metabolism of Pinacidil can be increased when combined with Rifabutin.Withdrawn
PinaveriumThe serum concentration of Pinaverium can be decreased when it is combined with Rifabutin.Approved
PioglitazoneThe metabolism of Pioglitazone can be increased when combined with Rifabutin.Approved, Investigational
PipotiazineThe metabolism of Pipotiazine can be increased when combined with Rifabutin.Approved
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Rifabutin.Approved
PodofiloxThe metabolism of Podofilox can be increased when combined with Rifabutin.Approved
PomalidomideThe metabolism of Pomalidomide can be increased when combined with Rifabutin.Approved
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with Rifabutin.Approved
PosaconazoleThe metabolism of Posaconazole can be increased when combined with Rifabutin.Approved, Investigational, Vet Approved
PrasteroneThe metabolism of Prasterone can be increased when combined with Rifabutin.Approved, Nutraceutical
PrasugrelThe metabolism of Prasugrel can be increased when combined with Rifabutin.Approved
PravastatinThe metabolism of Pravastatin can be increased when combined with Rifabutin.Approved
PrazepamThe metabolism of Prazepam can be increased when combined with Rifabutin.Approved, Illicit
PraziquantelThe serum concentration of Praziquantel can be decreased when it is combined with Rifabutin.Approved, Vet Approved
PrednicarbateThe serum concentration of Prednicarbate can be decreased when it is combined with Rifabutin.Approved
PrednisoloneThe metabolism of Prednisolone can be increased when combined with Rifabutin.Approved, Vet Approved
PrednisoloneThe serum concentration of Prednisolone can be decreased when it is combined with Rifabutin.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be decreased when it is combined with Rifabutin.Approved, Vet Approved
PregabalinThe serum concentration of Pregabalin can be decreased when it is combined with Rifabutin.Approved, Illicit, Investigational
PregnenoloneThe serum concentration of Pregnenolone can be decreased when it is combined with Rifabutin.Experimental
PrenylamineThe serum concentration of Prenylamine can be decreased when it is combined with Rifabutin.Withdrawn
PrimaquineThe metabolism of Primaquine can be increased when combined with Rifabutin.Approved
PrimidoneThe metabolism of Rifabutin can be increased when combined with Primidone.Approved, Vet Approved
ProchlorperazineThe metabolism of Prochlorperazine can be increased when combined with Rifabutin.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be increased when combined with Rifabutin.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be increased when combined with Rifabutin.Approved
PromazineThe metabolism of Promazine can be increased when combined with Rifabutin.Approved, Vet Approved
PropafenoneThe serum concentration of Propafenone can be decreased when it is combined with Rifabutin.Approved
PropofolThe metabolism of Propofol can be increased when combined with Rifabutin.Approved, Investigational, Vet Approved
PropranololThe metabolism of Propranolol can be increased when combined with Rifabutin.Approved, Investigational
PyrazinamideThe metabolism of Pyrazinamide can be increased when combined with Rifabutin.Approved
QuazepamThe metabolism of Quazepam can be increased when combined with Rifabutin.Approved, Illicit
QuetiapineThe serum concentration of Quetiapine can be decreased when it is combined with Rifabutin.Approved
QuinacrineThe metabolism of Quinacrine can be increased when combined with Rifabutin.Approved
QuinidineThe serum concentration of Quinidine can be decreased when it is combined with Rifabutin.Approved
QuinineThe metabolism of Quinine can be increased when combined with Rifabutin.Approved
RabeprazoleThe metabolism of Rabeprazole can be increased when combined with Rifabutin.Approved, Investigational
RadicicolThe serum concentration of Rifabutin can be increased when it is combined with Radicicol.Experimental
RaloxifeneThe metabolism of Raloxifene can be increased when combined with Rifabutin.Approved, Investigational
RaltegravirThe serum concentration of Raltegravir can be decreased when it is combined with Rifabutin.Approved
RamelteonThe metabolism of Ramelteon can be increased when combined with Rifabutin.Approved, Investigational
RanolazineThe serum concentration of Ranolazine can be decreased when it is combined with Rifabutin.Approved, Investigational
ReboxetineThe metabolism of Reboxetine can be increased when combined with Rifabutin.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be decreased when it is combined with Rifabutin.Approved
RepaglinideThe metabolism of Repaglinide can be increased when combined with Rifabutin.Approved, Investigational
RetapamulinThe metabolism of Retapamulin can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Rifampicin can be increased when combined with Rifabutin.Approved
RifapentineThe metabolism of Rifabutin can be increased when combined with Rifapentine.Approved
RilpivirineThe serum concentration of Rilpivirine can be decreased when it is combined with Rifabutin.Approved
RimexoloneThe serum concentration of Rimexolone can be decreased when it is combined with Rifabutin.Approved
RimonabantThe metabolism of Rimonabant can be increased when combined with Rifabutin.Approved, Investigational
RiociguatThe metabolism of Riociguat can be increased when combined with Rifabutin.Approved
RisedronateThe serum concentration of Risedronate can be decreased when it is combined with Rifabutin.Approved, Investigational
RisperidoneThe metabolism of Risperidone can be increased when combined with Rifabutin.Approved, Investigational
RitonavirThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Ritonavir.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be decreased when it is combined with Rifabutin.Approved
RofecoxibThe metabolism of Rofecoxib can be increased when combined with Rifabutin.Investigational, Withdrawn
RoflumilastThe serum concentration of Roflumilast can be decreased when it is combined with Rifabutin.Approved
RolapitantThe serum concentration of Rolapitant can be decreased when it is combined with Rifabutin.Approved
RomidepsinThe serum concentration of Romidepsin can be decreased when it is combined with Rifabutin.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be increased when combined with Rifabutin.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be increased when combined with Rifabutin.Approved
RosuvastatinThe metabolism of Rosuvastatin can be increased when combined with Rifabutin.Approved
RotigotineThe metabolism of Rotigotine can be increased when combined with Rifabutin.Approved
RoxithromycinThe metabolism of Roxithromycin can be increased when combined with Rifabutin.Approved, Withdrawn
RuxolitinibThe metabolism of Ruxolitinib can be increased when combined with Rifabutin.Approved
Salicylhydroxamic AcidThe serum concentration of Rifabutin can be increased when it is combined with Salicylhydroxamic Acid.Experimental
Salicylic acidThe serum concentration of Rifabutin can be increased when it is combined with Salicylic acid.Approved, Vet Approved
SalmeterolThe metabolism of Salmeterol can be increased when combined with Rifabutin.Approved
SaquinavirThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Saquinavir.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Rifabutin.Approved
SecobarbitalThe metabolism of Secobarbital can be increased when combined with Rifabutin.Approved, Vet Approved
SelegilineThe metabolism of Selegiline can be increased when combined with Rifabutin.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be increased when combined with Rifabutin.Approved
SeratrodastThe metabolism of Seratrodast can be increased when combined with Rifabutin.Approved, Investigational
SertaconazoleThe serum concentration of Rifabutin can be increased when it is combined with Sertaconazole.Approved
SertindoleThe metabolism of Sertindole can be increased when combined with Rifabutin.Approved, Withdrawn
SertralineThe metabolism of Sertraline can be increased when combined with Rifabutin.Approved
SevofluraneThe metabolism of Sevoflurane can be increased when combined with Rifabutin.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be increased when combined with Rifabutin.Approved, Illicit, Investigational, Withdrawn
SildenafilThe metabolism of Sildenafil can be increased when combined with Rifabutin.Approved, Investigational
SilodosinThe metabolism of Silodosin can be increased when combined with Rifabutin.Approved
SiltuximabThe serum concentration of Rifabutin can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Simeprevir can be decreased when it is combined with Rifabutin.Approved
SimvastatinThe metabolism of Simvastatin can be increased when combined with Rifabutin.Approved
SinefunginThe serum concentration of Rifabutin can be increased when it is combined with Sinefungin.Experimental
SirolimusThe metabolism of Sirolimus can be increased when combined with Rifabutin.Approved, Investigational
SitagliptinThe metabolism of Sitagliptin can be increased when combined with Rifabutin.Approved, Investigational
SofosbuvirThe serum concentration of Sofosbuvir can be decreased when it is combined with Rifabutin.Approved
SolifenacinThe metabolism of Solifenacin can be increased when combined with Rifabutin.Approved
SolithromycinThe metabolism of Rifabutin can be decreased when combined with Solithromycin.Investigational
SonidegibThe serum concentration of Sonidegib can be decreased when it is combined with Rifabutin.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be decreased when it is combined with Rifabutin.Approved, Investigational
SpiramycinThe metabolism of Spiramycin can be increased when combined with Rifabutin.Approved
St. John's WortThe serum concentration of Rifabutin can be decreased when it is combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Rifabutin can be increased when it is combined with Stiripentol.Approved
SufentanilThe metabolism of Sufentanil can be increased when combined with Rifabutin.Approved, Investigational
SulconazoleThe serum concentration of Rifabutin can be increased when it is combined with Sulconazole.Approved
SulfadiazineThe metabolism of Sulfadiazine can be increased when combined with Rifabutin.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be increased when combined with Rifabutin.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be increased when combined with Rifabutin.Approved
SulfisoxazoleThe metabolism of Rifabutin can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SunitinibThe serum concentration of Sunitinib can be decreased when it is combined with Rifabutin.Approved, Investigational
SuvorexantThe serum concentration of Suvorexant can be decreased when it is combined with Rifabutin.Approved
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be increased when combined with Rifabutin.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be increased when combined with Rifabutin.Approved
TacrolimusThe metabolism of Tacrolimus can be increased when combined with Rifabutin.Approved, Investigational
TacrolimusThe serum concentration of Tacrolimus can be decreased when it is combined with Rifabutin.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be decreased when it is combined with Rifabutin.Approved, Investigational
TamoxifenThe metabolism of Tamoxifen can be increased when combined with Rifabutin.Approved
TamsulosinThe metabolism of Tamsulosin can be increased when combined with Rifabutin.Approved, Investigational
TasimelteonThe serum concentration of Tasimelteon can be decreased when it is combined with Rifabutin.Approved
TasosartanThe metabolism of Tasosartan can be increased when combined with Rifabutin.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be increased when combined with Rifabutin.Experimental
TavaboroleThe serum concentration of Rifabutin can be increased when it is combined with Tavaborole.Approved
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Rifabutin.Approved
TelithromycinThe metabolism of Telithromycin can be increased when combined with Rifabutin.Approved
TemazepamThe metabolism of Temazepam can be increased when combined with Rifabutin.Approved
TemsirolimusThe serum concentration of Temsirolimus can be decreased when it is combined with Rifabutin.Approved
TeniposideThe metabolism of Teniposide can be increased when combined with Rifabutin.Approved
TenofovirThe metabolism of Rifabutin can be decreased when combined with Tenofovir.Approved, Investigational
TerbinafineThe metabolism of Terbinafine can be increased when combined with Rifabutin.Approved, Investigational, Vet Approved
TerconazoleThe serum concentration of Rifabutin can be increased when it is combined with Terconazole.Approved
TerfenadineThe metabolism of Terfenadine can be increased when combined with Rifabutin.Withdrawn
TeriflunomideThe serum concentration of Rifabutin can be decreased when it is combined with Teriflunomide.Approved
TesmilifeneThe metabolism of Tesmilifene can be increased when combined with Rifabutin.Investigational
TestosteroneThe metabolism of Testosterone can be increased when combined with Rifabutin.Approved, Investigational
TetracyclineThe metabolism of Tetracycline can be increased when combined with Rifabutin.Approved, Vet Approved
TheophyllineThe metabolism of Theophylline can be increased when combined with Rifabutin.Approved
ThiamylalThe metabolism of Thiamylal can be increased when combined with Rifabutin.Approved, Vet Approved
ThiopentalThe metabolism of Thiopental can be increased when combined with Rifabutin.Approved, Vet Approved
ThiotepaThe metabolism of Thiotepa can be increased when combined with Rifabutin.Approved
ThymolThe serum concentration of Rifabutin can be increased when it is combined with Thymol.Approved
TiagabineThe metabolism of Tiagabine can be increased when combined with Rifabutin.Approved
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Rifabutin resulting in a loss in efficacy.Approved
TiclopidineThe metabolism of Ticlopidine can be increased when combined with Rifabutin.Approved
TinidazoleThe metabolism of Tinidazole can be increased when combined with Rifabutin.Approved, Investigational
TioconazoleThe serum concentration of Rifabutin can be increased when it is combined with Tioconazole.Approved
TiotropiumThe metabolism of Tiotropium can be increased when combined with Rifabutin.Approved
TipranavirThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Tipranavir.Approved, Investigational
TixocortolThe serum concentration of Tixocortol can be decreased when it is combined with Rifabutin.Approved
TocilizumabThe serum concentration of Rifabutin can be decreased when it is combined with Tocilizumab.Approved
TofacitinibThe serum concentration of Tofacitinib can be decreased when it is combined with Rifabutin.Approved, Investigational
Tolfenamic AcidThe serum concentration of Tolfenamic Acid can be decreased when it is combined with Rifabutin.Approved
TolnaftateThe serum concentration of Rifabutin can be increased when it is combined with Tolnaftate.Approved, Vet Approved
TolterodineThe metabolism of Tolterodine can be increased when combined with Rifabutin.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be decreased when it is combined with Rifabutin.Approved
ToremifeneThe serum concentration of Toremifene can be decreased when it is combined with Rifabutin.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be decreased when it is combined with Rifabutin.Approved, Investigational
TramadolThe metabolism of Tramadol can be increased when combined with Rifabutin.Approved, Investigational
TranilastThe serum concentration of Tranilast can be decreased when it is combined with Rifabutin.Approved, Investigational
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be increased when combined with Rifabutin.Approved
TrazodoneThe metabolism of Trazodone can be increased when combined with Rifabutin.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be increased when combined with Rifabutin.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be increased when combined with Rifabutin.Approved, Vet Approved
TriazolamThe metabolism of Triazolam can be increased when combined with Rifabutin.Approved
TrimethadioneThe metabolism of Trimethadione can be increased when combined with Rifabutin.Approved
TrimethoprimThe metabolism of Trimethoprim can be increased when combined with Rifabutin.Approved, Vet Approved
TrimetrexateThe serum concentration of Rifabutin can be increased when it is combined with Trimetrexate.Approved, Investigational
TrimipramineThe metabolism of Trimipramine can be increased when combined with Rifabutin.Approved
TroglitazoneThe metabolism of Troglitazone can be increased when combined with Rifabutin.Withdrawn
TroleandomycinThe metabolism of Troleandomycin can be increased when combined with Rifabutin.Approved
TylosinThe metabolism of Rifabutin can be decreased when combined with Tylosin.Vet Approved
UdenafilThe metabolism of Udenafil can be increased when combined with Rifabutin.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be decreased when it is combined with Rifabutin.Approved
ValdecoxibThe metabolism of Valdecoxib can be increased when combined with Rifabutin.Investigational, Withdrawn
VandetanibThe serum concentration of Vandetanib can be decreased when it is combined with Rifabutin.Approved
VanoxerineThe metabolism of Vanoxerine can be increased when combined with Rifabutin.Investigational
VardenafilThe metabolism of Vardenafil can be increased when combined with Rifabutin.Approved
VemurafenibThe serum concentration of Vemurafenib can be decreased when it is combined with Rifabutin.Approved
VenetoclaxThe metabolism of Venetoclax can be increased when combined with Rifabutin.Approved
VenlafaxineThe metabolism of Venlafaxine can be increased when combined with Rifabutin.Approved
VerapamilThe metabolism of Verapamil can be increased when combined with Rifabutin.Approved
VicrivirocThe metabolism of Vicriviroc can be increased when combined with Rifabutin.Investigational
VilanterolThe metabolism of Vilanterol can be increased when combined with Rifabutin.Approved
VilazodoneThe serum concentration of Vilazodone can be decreased when it is combined with Rifabutin.Approved
VinblastineThe metabolism of Vinblastine can be increased when combined with Rifabutin.Approved
VincristineThe serum concentration of Vincristine can be decreased when it is combined with Rifabutin.Approved, Investigational
VincristineThe metabolism of Vincristine can be increased when combined with Rifabutin.Approved, Investigational
VindesineThe metabolism of Vindesine can be increased when combined with Rifabutin.Approved
VinorelbineThe metabolism of Vinorelbine can be increased when combined with Rifabutin.Approved, Investigational
VinpocetineThe serum concentration of Vinpocetine can be decreased when it is combined with Rifabutin.Investigational
VismodegibThe metabolism of Vismodegib can be increased when combined with Rifabutin.Approved
VorapaxarThe serum concentration of Vorapaxar can be decreased when it is combined with Rifabutin.Approved
VoriconazoleThe serum concentration of Rifabutin can be increased when it is combined with Voriconazole.Approved, Investigational
VortioxetineThe serum concentration of Vortioxetine can be decreased when it is combined with Rifabutin.Approved
WarfarinThe metabolism of Warfarin can be increased when combined with Rifabutin.Approved
XylometazolineThe serum concentration of Xylometazoline can be decreased when it is combined with Rifabutin.Approved
YohimbineThe metabolism of Yohimbine can be increased when combined with Rifabutin.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be increased when combined with Rifabutin.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be increased when combined with Rifabutin.Approved
ZaleplonThe serum concentration of Zaleplon can be decreased when it is combined with Rifabutin.Approved, Illicit, Investigational
ZiconotideThe serum concentration of Ziconotide can be decreased when it is combined with Rifabutin.Approved
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Rifabutin.Approved
ZileutonThe metabolism of Zileuton can be increased when combined with Rifabutin.Approved, Investigational, Withdrawn
ZiprasidoneThe metabolism of Ziprasidone can be increased when combined with Rifabutin.Approved
ZolpidemThe serum concentration of Zolpidem can be decreased when it is combined with Rifabutin.Approved
ZomepiracThe metabolism of Zomepirac can be increased when combined with Rifabutin.Withdrawn
ZonisamideThe metabolism of Zonisamide can be increased when combined with Rifabutin.Approved, Investigational
ZopicloneThe metabolism of Zopiclone can be increased when combined with Rifabutin.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be decreased when it is combined with Rifabutin.Approved, Investigational
Food Interactions
  • High-fat meals slow the rate of absorption.
  • Take with food to reduce irritation.
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesJ04AB04
AHFS Codes
  • 08:16.04
PDB EntriesNot Available
FDA labelDownload (69.5 KB)
MSDSDownload (58.4 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.5507
Blood Brain Barrier-0.9921
Caco-2 permeable-0.7072
P-glycoprotein substrateSubstrate0.9612
P-glycoprotein inhibitor IInhibitor0.5415
P-glycoprotein inhibitor IIInhibitor0.6516
Renal organic cation transporterNon-inhibitor0.8178
CYP450 2C9 substrateNon-substrate0.819
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.745
CYP450 1A2 substrateNon-inhibitor0.9046
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorNon-inhibitor0.8308
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8909
Ames testNon AMES toxic0.6724
CarcinogenicityNon-carcinogens0.9195
BiodegradationNot ready biodegradable0.9687
Rat acute toxicity2.5143 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.946
hERG inhibition (predictor II)Inhibitor0.5416
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Pharmacia and upjohn co
Packagers
Dosage forms
FormRouteStrength
CapsuleOral150 mg/1
CapsuleOral150 mg
Prices
Unit descriptionCostUnit
Mycobutin 150 mg capsule13.01USD capsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
water solubilityMinimally soluble (0.19 mg/mL)Not Available
logP4.1Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.017 mg/mLALOGPS
logP4.25ALOGPS
logP4.19ChemAxon
logS-4.7ALOGPS
pKa (Strongest Acidic)7.93ChemAxon
pKa (Strongest Basic)8.62ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count13ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area205.55 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity232.64 m3·mol-1ChemAxon
Polarizability90.72 Å3ChemAxon
Number of Rings6ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as macrolactams. These are cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. They are nitrogen analogues (the a nitrogen atom replacing the o atom of the cyclic carboxylic acid group ) of the naturally occurring macrolides.
KingdomOrganic compounds
Super ClassPhenylpropanoids and polyketides
ClassMacrolactams
Sub ClassNot Available
Direct ParentMacrolactams
Alternative Parents
Substituents
  • Naphthofuran
  • Macrolactam
  • Naphthalene
  • Azaspirodecane
  • Benzofuran
  • Aryl alkyl ketone
  • Aryl ketone
  • Benzenoid
  • Piperidine
  • Acetate salt
  • Vinylogous amide
  • Vinylogous acid
  • 3-imidazoline
  • Tertiary aliphatic amine
  • Tertiary amine
  • Secondary carboxylic acid amide
  • Secondary alcohol
  • Polyol
  • Lactam
  • Ketone
  • Ketimine
  • Carboxylic acid ester
  • Carboxamide group
  • Oxacycle
  • Azacycle
  • Organoheterocyclic compound
  • Organic 1,3-dipolar compound
  • Propargyl-type 1,3-dipolar organic compound
  • Ether
  • Dialkyl ether
  • Carboxylic acid derivative
  • Carboxylic acid amide
  • Acetal
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Imine
  • Carbonyl group
  • Amine
  • Alcohol
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available

Targets

Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
yes
Actions
inhibitor
General Function:
Zinc ion binding
Specific Function:
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit plays an important role in subunit assembly since its dimerization is the first step in the sequential assembly of subunits to form the holoenzyme.
Gene Name:
rpoA
Uniprot ID:
P0A7Z4
Molecular Weight:
36511.35 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Maddix DS, Tallian KB, Mead PS: Rifabutin: a review with emphasis on its role in the prevention of disseminated Mycobacterium avium complex infection. Ann Pharmacother. 1994 Nov;28(11):1250-4. [PubMed:7849340 ]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
yes
Actions
inhibitor
General Function:
Ribonucleoside binding
Specific Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Gene Name:
rpoB
Uniprot ID:
P0A8V2
Molecular Weight:
150631.165 Da
References
  1. Maddix DS, Tallian KB, Mead PS: Rifabutin: a review with emphasis on its role in the prevention of disseminated Mycobacterium avium complex infection. Ann Pharmacother. 1994 Nov;28(11):1250-4. [PubMed:7849340 ]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
yes
Actions
inhibitor
General Function:
Dna-directed rna polymerase activity
Specific Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Gene Name:
rpoC
Uniprot ID:
P0A8T7
Molecular Weight:
155158.84 Da
References
  1. Maddix DS, Tallian KB, Mead PS: Rifabutin: a review with emphasis on its role in the prevention of disseminated Mycobacterium avium complex infection. Ann Pharmacother. 1994 Nov;28(11):1250-4. [PubMed:7849340 ]
Kind
Protein
Organism
Human
Pharmacological action
no
Actions
other/unknown
General Function:
Tpr domain binding
Specific Function:
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with v...
Gene Name:
HSP90AA1
Uniprot ID:
P07900
Molecular Weight:
84659.015 Da
References
  1. Schnaider T, Somogyi J, Csermely P, Szamel M: The Hsp90-specific inhibitor geldanamycin selectively disrupts kinase-mediated signaling events of T-lymphocyte activation. Cell Stress Chaperones. 2000 Jan;5(1):52-61. [PubMed:10701840 ]
  2. Neckers L, Schulte TW, Mimnaugh E: Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity. Invest New Drugs. 1999;17(4):361-73. [PubMed:10759403 ]
  3. Srethapakdi M, Liu F, Tavorath R, Rosen N: Inhibition of Hsp90 function by ansamycins causes retinoblastoma gene product-dependent G1 arrest. Cancer Res. 2000 Jul 15;60(14):3940-6. [PubMed:10919672 ]
  4. Munster PN, Srethapakdi M, Moasser MM, Rosen N: Inhibition of heat shock protein 90 function by ansamycins causes the morphological and functional differentiation of breast cancer cells. Cancer Res. 2001 Apr 1;61(7):2945-52. [PubMed:11306472 ]
  5. Yang J, Yang JM, Iannone M, Shih WJ, Lin Y, Hait WN: Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to inhibit glioblastoma by geldanamycin. Cancer Res. 2001 May 15;61(10):4010-6. [PubMed:11358819 ]
Kind
Protein
Organism
Human
Pharmacological action
no
Actions
other/unknown
General Function:
Virion binding
Specific Function:
Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.
Gene Name:
HSP90B1
Uniprot ID:
P14625
Molecular Weight:
92468.06 Da
References
  1. Barzilay E, Ben-Califa N, Supino-Rosin L, Kashman Y, Hirschberg K, Elazar Z, Neumann D: Geldanamycin-associated inhibition of intracellular trafficking is attributed to a co-purified activity. J Biol Chem. 2004 Feb 20;279(8):6847-52. Epub 2003 Dec 1. [PubMed:14660597 ]
  2. Chavany C, Mimnaugh E, Miller P, Bitton R, Nguyen P, Trepel J, Whitesell L, Schnur R, Moyer J, Neckers L: p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2. J Biol Chem. 1996 Mar 1;271(9):4974-7. [PubMed:8617772 ]
  3. Lawson B, Brewer JW, Hendershot LM: Geldanamycin, an hsp90/GRP94-binding drug, induces increased transcription of endoplasmic reticulum (ER) chaperones via the ER stress pathway. J Cell Physiol. 1998 Feb;174(2):170-8. [PubMed:9428803 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Ekins S, Bravi G, Wikel JH, Wrighton SA: Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates. J Pharmacol Exp Ther. 1999 Oct;291(1):424-33. [PubMed:10490933 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23