Identification

Name
Rifabutin
Accession Number
DB00615  (APRD00094)
Type
Small Molecule
Groups
Approved
Description

A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. [PubChem]

Structure
Thumb
Synonyms
  • 1,4-Dihydro-1-deoxy-1',4-didehydro-5'-(2-methylpropyl)-1-oxorifamycin xiv
  • 4-Deoxo-3,4-(2-spiro(N-isobutyl-4-piperidyl)-2,5-dihydro-1H-imidazo)-rifamycin S
  • 4-N-Isobutylspiropiperidylrifamycin S
  • Ansamicin
  • Ansamycin
  • Mycobutin (tn)
  • Rifabutin
  • Rifabutina
  • Rifabutine
  • Rifabutinum
External IDs
LM 427 / LM-427
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
MycobutinCapsule150 mg/1OralPhysicians Total Care, Inc.1995-03-15Not applicableUs
MycobutinCapsule150 mgOralPfizer1995-12-31Not applicableCanada
MycobutinCapsule150 mg/1OralPharmacia & Upjohn Inc1992-12-23Not applicableUs00013 5301 17 nlmimage10 691e34b1
MycobutinCapsule150 mg/1OralDepartment Of State Health Services, Pharmacy Branch1992-12-23Not applicableUs
RifabutinCapsule150 mg/1OralGreenstone, Llc2014-04-07Not applicableUs
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
RifabutinCapsule150 mg/1OralLupin Pharmaceuticals2014-03-26Not applicableUs
RifabutinCapsule150 mg/1OralAmerincan Health Packaging2016-07-01Not applicableUs
RifabutinCapsule150 mg/1OralAvera Mc Kennan Hospital2016-03-03Not applicableUs
International/Other Brands
Ansatipin (Pfizer) / Ansatipine (SERB) / Ributin (Lupin)
Categories
UNII
1W306TDA6S
CAS number
72559-06-9
Weight
Average: 847.0047
Monoisotopic: 846.441508846
Chemical Formula
C46H62N4O11
InChI Key
ATEBXHFBFRCZMA-VXTBVIBXSA-N
InChI
InChI=1S/C46H62N4O11/c1-22(2)21-50-18-16-46(17-19-50)48-34-31-32-39(54)28(8)42-33(31)43(56)45(10,61-42)59-20-15-30(58-11)25(5)41(60-29(9)51)27(7)38(53)26(6)37(52)23(3)13-12-14-24(4)44(57)47-36(40(32)55)35(34)49-46/h12-15,20,22-23,25-27,30,37-38,41,49,52-54H,16-19,21H2,1-11H3,(H,47,57)/b13-12+,20-15+,24-14-/t23-,25+,26+,27+,30-,37-,38+,41+,45-/m0/s1
IUPAC Name
(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17-trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-1'-(2-methylpropyl)-6,23,32-trioxo-8,33-dioxa-24,27,29-triazaspiro[pentacyclo[23.6.1.1⁴,⁷.0⁵,³¹.0²⁶,³⁰]tritriacontane-28,4'-piperidin]-1(31),2,4,9,19,21,25,29-octaen-13-yl acetate
SMILES
CO[[email protected]]1\C=C\O[[email protected]@]2(C)OC3=C(C2=O)C2=C(C(O)=C3C)C(=O)C(NC(=O)\C(C)=C/C=C/[[email protected]](C)[[email protected]](O)[[email protected]@H](C)[[email protected]@H](O)[[email protected]@H](C)[[email protected]](OC(C)=O)[[email protected]@H]1C)=C1NC3(CCN(CC3)CC(C)C)N=C21

Pharmacology

Indication

For the prevention of disseminated Mycobacterium avium complex (MAC) disease in patients with advanced HIV infection.

Structured Indications
Pharmacodynamics

Rifabutin is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. It is bactericidal and has a very broad spectrum of activity against most gram-positive and gram-negative organisms (including Pseudomonas aeruginosa) and specifically Mycobacterium tuberculosis. Because of rapid emergence of resistant bacteria, use is restricted to treatment of mycobacterial infections and a few other indications. Rifabutin is well absorbed when taken orally and is distributed widely in body tissues and fluids, including the CSF. It is metabolized in the liver and eliminated in bile and, to a much lesser extent, in urine, but dose adjustments are unnecessary with renal insufficiency.

Mechanism of action

Rifabutin acts via the inhibition of DNA-dependent RNA polymerase in gram-positive and some gram-negative bacteria, leading to a suppression of RNA synthesis and cell death.

TargetActionsOrganism
ADNA-directed RNA polymerase subunit alpha
inhibitor
Escherichia coli (strain K12)
ADNA-directed RNA polymerase subunit beta
inhibitor
Escherichia coli (strain K12)
ADNA-directed RNA polymerase subunit beta'
inhibitor
Escherichia coli (strain K12)
NHeat shock protein HSP 90-alpha
other/unknown
Human
NEndoplasmin
other/unknown
Human
Absorption

Rifabutin is readily absorbed from the gastrointestinal tract, with an absolute bioavailability averaging 20%.

Volume of distribution
Not Available
Protein binding

85%

Metabolism

Hepatic. Of the five metabolites that have been identified, 25-O-desacetyl and 31-hydroxy are the most predominant. The former metabolite has an activity equal to the parent drug and contributes up to 10% to the total antimicrobial activity.

Route of elimination

A mass-balance study in three healthy adult volunteers with 14C-labeled rifabutin showed that 53% of the oral dose was excreted in the urine, primarily as metabolites. About 30% of the dose is excreted in the feces.

Half life

45 (± 17) hours

Clearance
  • 0.69 +/- 0.32 L/hr/kg
Toxicity

LD50 = 4.8 g/kg (mouse, male)

Affected organisms
  • Enteric bacteria and other eubacteria
  • Mycobacterium tuberculosis
  • Mycobacterium leprae
  • Mycobacterium avium
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
16-BromoepiandrosteroneThe serum concentration of 16-Bromoepiandrosterone can be decreased when it is combined with Rifabutin.Investigational
19-norandrostenedioneThe serum concentration of 19-norandrostenedione can be decreased when it is combined with Rifabutin.Experimental, Illicit
2-HYDROXY-1,4-NAPHTHOQUINONEThe serum concentration of Rifabutin can be increased when it is combined with 2-HYDROXY-1,4-NAPHTHOQUINONE.Experimental
2-mercaptobenzothiazoleThe serum concentration of Rifabutin can be increased when it is combined with 2-mercaptobenzothiazole.Vet Approved
5-androstenedioneThe serum concentration of 5-androstenedione can be decreased when it is combined with Rifabutin.Experimental, Illicit
AbirateroneThe serum concentration of Rifabutin can be increased when it is combined with Abiraterone.Approved
AcenocoumarolThe metabolism of Acenocoumarol can be increased when combined with Rifabutin.Approved
AcetaminophenThe metabolism of Acetaminophen can be increased when combined with Rifabutin.Approved
AdinazolamThe metabolism of Adinazolam can be increased when combined with Rifabutin.Approved
AlbendazoleThe metabolism of Albendazole can be increased when combined with Rifabutin.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be increased when combined with Rifabutin.Approved
AldosteroneThe serum concentration of Aldosterone can be decreased when it is combined with Rifabutin.Experimental, Investigational
AlfentanilThe serum concentration of Alfentanil can be decreased when it is combined with Rifabutin.Approved, Illicit
AlfuzosinThe metabolism of Alfuzosin can be increased when combined with Rifabutin.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be increased when combined with Rifabutin.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be increased when combined with Rifabutin.Approved
AlmotriptanThe metabolism of Almotriptan can be increased when combined with Rifabutin.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be increased when combined with Rifabutin.Approved
AlosetronThe metabolism of Alosetron can be increased when combined with Rifabutin.Approved, Withdrawn
AlprazolamThe metabolism of Alprazolam can be increased when combined with Rifabutin.Approved, Illicit, Investigational
AmbrisentanThe metabolism of Ambrisentan can be increased when combined with Rifabutin.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be increased when combined with Rifabutin.Approved, Investigational
AmcinonideThe serum concentration of Amcinonide can be decreased when it is combined with Rifabutin.Approved
AminophenazoneThe metabolism of Aminophenazone can be increased when combined with Rifabutin.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be increased when combined with Rifabutin.Approved
AmiodaroneThe metabolism of Amiodarone can be increased when combined with Rifabutin.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be increased when combined with Rifabutin.Approved
AmlodipineThe metabolism of Amlodipine can be increased when combined with Rifabutin.Approved
AmobarbitalThe metabolism of Amobarbital can be increased when combined with Rifabutin.Approved, Illicit
AmorolfineThe serum concentration of Rifabutin can be increased when it is combined with Amorolfine.Approved, Investigational
Amphotericin BThe serum concentration of Rifabutin can be increased when it is combined with Amphotericin B.Approved, Investigational
AmprenavirThe metabolism of Amprenavir can be increased when combined with Rifabutin.Approved
AmrinoneThe serum concentration of Amrinone can be decreased when it is combined with Rifabutin.Approved
AndrostenedioneThe serum concentration of Androstenedione can be decreased when it is combined with Rifabutin.Experimental, Illicit
AnecortaveThe serum concentration of Anecortave can be decreased when it is combined with Rifabutin.Investigational
anecortave acetateThe serum concentration of anecortave acetate can be decreased when it is combined with Rifabutin.Investigational
AnidulafunginThe serum concentration of Rifabutin can be increased when it is combined with Anidulafungin.Approved, Investigational
AntipyrineThe metabolism of Antipyrine can be increased when combined with Rifabutin.Approved
ApixabanThe serum concentration of Apixaban can be decreased when it is combined with Rifabutin.Approved
ApremilastThe serum concentration of Apremilast can be decreased when it is combined with Rifabutin.Approved, Investigational
AprepitantThe serum concentration of Rifabutin can be increased when it is combined with Aprepitant.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be increased when combined with Rifabutin.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Rifabutin.Approved, Investigational
ArtemetherThe serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with Rifabutin resulting in a loss in efficacy.Approved
AsenapineThe metabolism of Asenapine can be increased when combined with Rifabutin.Approved
AstemizoleThe metabolism of Astemizole can be increased when combined with Rifabutin.Approved, Withdrawn
AtamestaneThe serum concentration of Atamestane can be decreased when it is combined with Rifabutin.Investigational
AtazanavirThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Atazanavir.Approved, Investigational
AtomoxetineThe metabolism of Rifabutin can be decreased when combined with Atomoxetine.Approved
AtorvastatinThe metabolism of Atorvastatin can be increased when combined with Rifabutin.Approved
AtovaquoneThe serum concentration of Atovaquone can be decreased when it is combined with Rifabutin.Approved
AvanafilThe metabolism of Avanafil can be increased when combined with Rifabutin.Approved
AxitinibThe serum concentration of Axitinib can be decreased when it is combined with Rifabutin.Approved, Investigational
AzelastineThe metabolism of Azelastine can be increased when combined with Rifabutin.Approved
AzelnidipineThe serum concentration of Azelnidipine can be decreased when it is combined with Rifabutin.Approved, Investigational
AzimilideThe serum concentration of Azimilide can be decreased when it is combined with Rifabutin.Investigational
AzithromycinThe metabolism of Azithromycin can be increased when combined with Rifabutin.Approved
Bafilomycin A1The serum concentration of Rifabutin can be increased when it is combined with Bafilomycin A1.Experimental
BanoxantroneThe metabolism of Banoxantrone can be increased when combined with Rifabutin.Investigational
BarbexacloneThe metabolism of Barbexaclone can be increased when combined with Rifabutin.Experimental
BarbitalThe metabolism of Barbital can be increased when combined with Rifabutin.Illicit
BarnidipineThe serum concentration of Barnidipine can be decreased when it is combined with Rifabutin.Approved
BCG vaccineThe therapeutic efficacy of BCG vaccine can be decreased when used in combination with Rifabutin.Investigational
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be decreased when it is combined with Rifabutin.Approved, Investigational
BedaquilineThe serum concentration of Bedaquiline can be decreased when it is combined with Rifabutin.Approved
BencyclaneThe serum concentration of Bencyclane can be decreased when it is combined with Rifabutin.Experimental
BenidipineThe serum concentration of Benidipine can be decreased when it is combined with Rifabutin.Approved, Investigational
Benzoic AcidThe serum concentration of Rifabutin can be increased when it is combined with Benzoic Acid.Approved
BenzphetamineThe metabolism of Benzphetamine can be increased when combined with Rifabutin.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be increased when combined with Rifabutin.Approved
BepridilThe serum concentration of Bepridil can be decreased when it is combined with Rifabutin.Approved, Withdrawn
BetamethasoneThe serum concentration of Betamethasone can be decreased when it is combined with Rifabutin.Approved, Vet Approved
BexaroteneThe metabolism of Bexarotene can be increased when combined with Rifabutin.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be increased when combined with Rifabutin.Approved
BicalutamideThe metabolism of Bicalutamide can be increased when combined with Rifabutin.Approved
BifonazoleThe serum concentration of Rifabutin can be increased when it is combined with Bifonazole.Approved, Investigational
BisoprololThe metabolism of Bisoprolol can be increased when combined with Rifabutin.Approved
BoceprevirThe serum concentration of Boceprevir can be decreased when it is combined with Rifabutin.Approved, Withdrawn
BortezomibThe serum concentration of Bortezomib can be decreased when it is combined with Rifabutin.Approved, Investigational
BosentanThe serum concentration of Rifabutin can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be decreased when it is combined with Rifabutin.Approved
Brefeldin AThe serum concentration of Rifabutin can be increased when it is combined with 1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE.Experimental
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be decreased when it is combined with Rifabutin.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be decreased when it is combined with Rifabutin.Approved
BrinzolamideThe metabolism of Brinzolamide can be increased when combined with Rifabutin.Approved
BrivaracetamThe metabolism of Brivaracetam can be increased when combined with Rifabutin.Approved, Investigational
BromazepamThe metabolism of Bromazepam can be increased when combined with Rifabutin.Approved, Illicit
BromocriptineThe metabolism of Bromocriptine can be increased when combined with Rifabutin.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be increased when combined with Rifabutin.Approved
BudesonideThe metabolism of Budesonide can be increased when combined with Rifabutin.Approved
BupivacaineThe metabolism of Bupivacaine can be increased when combined with Rifabutin.Approved, Investigational
BuprenorphineThe metabolism of Buprenorphine can be increased when combined with Rifabutin.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be increased when combined with Rifabutin.Approved
BuspironeThe serum concentration of Buspirone can be decreased when it is combined with Rifabutin.Approved, Investigational
BusulfanThe metabolism of Busulfan can be increased when combined with Rifabutin.Approved, Investigational
ButenafineThe serum concentration of Rifabutin can be increased when it is combined with Butenafine.Approved
ButoconazoleThe serum concentration of Rifabutin can be increased when it is combined with Butoconazole.Approved
CabazitaxelThe metabolism of Cabazitaxel can be increased when combined with Rifabutin.Approved
CabergolineThe metabolism of Cabergoline can be increased when combined with Rifabutin.Approved
CabozantinibThe serum concentration of Cabozantinib can be decreased when it is combined with Rifabutin.Approved
CaffeineThe metabolism of Caffeine can be increased when combined with Rifabutin.Approved
CalcitriolThe metabolism of Calcitriol can be increased when combined with Rifabutin.Approved, Nutraceutical
CanagliflozinThe metabolism of Canagliflozin can be increased when combined with Rifabutin.Approved
CandicidinThe serum concentration of Rifabutin can be increased when it is combined with Candicidin.Withdrawn
CannabidiolThe serum concentration of Cannabidiol can be decreased when it is combined with Rifabutin.Approved, Investigational
Capric acidThe serum concentration of Rifabutin can be increased when it is combined with Capric acid.Experimental
CarbamazepineThe metabolism of Carbamazepine can be increased when combined with Rifabutin.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be increased when combined with Rifabutin.Approved
CarbomycinThe metabolism of Rifabutin can be decreased when combined with Carbomycin.Vet Approved
CarboxyamidotriazoleThe serum concentration of Carboxyamidotriazole can be decreased when it is combined with Rifabutin.Investigational
CariprazineThe metabolism of Cariprazine can be increased when combined with Rifabutin.Approved
CaroverineThe serum concentration of Caroverine can be decreased when it is combined with Rifabutin.Experimental
CarvedilolThe metabolism of Carvedilol can be increased when combined with Rifabutin.Approved, Investigational
CaspofunginThe serum concentration of Rifabutin can be increased when it is combined with Caspofungin.Approved
CelecoxibThe metabolism of Celecoxib can be increased when combined with Rifabutin.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be increased when combined with Rifabutin.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be increased when combined with Rifabutin.Approved, Vet Approved
CeritinibThe serum concentration of Rifabutin can be increased when it is combined with Ceritinib.Approved
CerivastatinThe metabolism of Cerivastatin can be increased when combined with Rifabutin.Withdrawn
CeruleninThe serum concentration of Rifabutin can be increased when it is combined with Cerulenin.Approved
CevimelineThe metabolism of Cevimeline can be increased when combined with Rifabutin.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be increased when combined with Rifabutin.Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be increased when combined with Rifabutin.Approved, Illicit
ChloroquineThe metabolism of Chloroquine can be increased when combined with Rifabutin.Approved, Vet Approved
ChlorotrianiseneThe serum concentration of Chlorotrianisene can be decreased when it is combined with Rifabutin.Investigational, Withdrawn
ChloroxineThe serum concentration of Rifabutin can be increased when it is combined with Chloroxine.Approved
ChlorphenamineThe metabolism of Chlorphenamine can be increased when combined with Rifabutin.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be increased when combined with Rifabutin.Approved, Vet Approved
ChlorzoxazoneThe metabolism of Chlorzoxazone can be increased when combined with Rifabutin.Approved
CholecalciferolThe metabolism of Cholecalciferol can be increased when combined with Rifabutin.Approved, Nutraceutical
CiclesonideThe metabolism of Ciclesonide can be increased when combined with Rifabutin.Approved, Investigational
CiclopiroxThe serum concentration of Rifabutin can be increased when it is combined with Ciclopirox.Approved, Investigational
CilnidipineThe serum concentration of Cilnidipine can be decreased when it is combined with Rifabutin.Approved, Investigational
CilostazolThe metabolism of Cilostazol can be increased when combined with Rifabutin.Approved
CinacalcetThe metabolism of Cinacalcet can be increased when combined with Rifabutin.Approved
CinnarizineThe serum concentration of Cinnarizine can be decreased when it is combined with Rifabutin.Approved, Investigational
CisaprideThe metabolism of Cisapride can be increased when combined with Rifabutin.Approved, Investigational, Withdrawn
CitalopramThe metabolism of Citalopram can be increased when combined with Rifabutin.Approved
ClarithromycinThe serum concentration of the active metabolites of Clarithromycin can be increased when Clarithromycin is used in combination with Rifabutin.Approved
ClemastineThe metabolism of Rifabutin can be decreased when combined with Clemastine.Approved
ClevidipineThe serum concentration of Clevidipine can be decreased when it is combined with Rifabutin.Approved
ClindamycinThe metabolism of Clindamycin can be increased when combined with Rifabutin.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be increased when combined with Rifabutin.Approved, Illicit
ClobetasolThe serum concentration of Clobetasol can be decreased when it is combined with Rifabutin.Investigational
Clobetasol propionateThe serum concentration of Clobetasol propionate can be decreased when it is combined with Rifabutin.Approved
ClobetasoneThe serum concentration of Clobetasone can be decreased when it is combined with Rifabutin.Approved
ClocortoloneThe serum concentration of Clocortolone can be decreased when it is combined with Rifabutin.Approved
ClofazimineThe metabolism of Clofazimine can be increased when combined with Rifabutin.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be increased when combined with Rifabutin.Approved, Investigational
clomethiazoleThe metabolism of clomethiazole can be increased when combined with Rifabutin.Investigational
ClomipramineThe metabolism of Clomipramine can be increased when combined with Rifabutin.Approved, Vet Approved
ClonazepamThe metabolism of Clonazepam can be increased when combined with Rifabutin.Approved, Illicit
ClonidineThe metabolism of Clonidine can be increased when combined with Rifabutin.Approved
ClopidogrelThe risk or severity of adverse effects can be increased when Rifabutin is combined with Clopidogrel.Approved, Nutraceutical
ClorazepateThe metabolism of Clorazepate can be increased when combined with Rifabutin.Approved, Illicit
ClorindioneThe metabolism of Clorindione can be increased when combined with Rifabutin.Experimental
ClotiazepamThe metabolism of Clotiazepam can be increased when combined with Rifabutin.Approved, Illicit
ClotrimazoleThe serum concentration of Rifabutin can be increased when it is combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be decreased when it is combined with Rifabutin.Approved
CobicistatThe metabolism of Rifabutin can be decreased when combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be decreased when it is combined with Rifabutin.Approved
CocaineThe metabolism of Cocaine can be increased when combined with Rifabutin.Approved, Illicit
CodeineThe metabolism of Codeine can be increased when combined with Rifabutin.Approved, Illicit
ColchicineThe metabolism of Colchicine can be increased when combined with Rifabutin.Approved
ConivaptanThe serum concentration of Rifabutin can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated estrogensThe metabolism of Conjugated estrogens can be increased when combined with Rifabutin.Approved
CopanlisibThe metabolism of Copanlisib can be increased when combined with Rifabutin.Approved
CordycepinThe serum concentration of Rifabutin can be increased when it is combined with Cordycepin.Investigational
Cortexolone 17α-propionateThe serum concentration of Cortexolone 17α-propionate can be decreased when it is combined with Rifabutin.Investigational
CorticosteroneThe serum concentration of Corticosterone can be decreased when it is combined with Rifabutin.Experimental
Cortisone acetateThe metabolism of Cortisone acetate can be increased when combined with Rifabutin.Approved
CrizotinibThe serum concentration of Crizotinib can be decreased when it is combined with Rifabutin.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be increased when combined with Rifabutin.Approved
CyclophosphamideThe metabolism of Cyclophosphamide can be increased when combined with Rifabutin.Approved, Investigational
Cyproterone acetateThe serum concentration of Rifabutin can be decreased when it is combined with Cyproterone acetate.Approved, Investigational
CytarabineThe metabolism of Cytarabine can be increased when combined with Rifabutin.Approved, Investigational
DabrafenibThe serum concentration of Rifabutin can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe serum concentration of Daclatasvir can be decreased when it is combined with Rifabutin.Approved
DantroleneThe metabolism of Dantrolene can be increased when combined with Rifabutin.Approved
DapagliflozinThe metabolism of Dapagliflozin can be increased when combined with Rifabutin.Approved
DarifenacinThe metabolism of Darifenacin can be increased when combined with Rifabutin.Approved, Investigational
DarodipineThe serum concentration of Darodipine can be decreased when it is combined with Rifabutin.Experimental
DarunavirThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Darunavir.Approved
DasabuvirThe metabolism of Dasabuvir can be increased when combined with Rifabutin.Approved
DasatinibThe serum concentration of Dasatinib can be decreased when it is combined with Rifabutin.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be increased when combined with Rifabutin.Approved
DeferasiroxThe serum concentration of Rifabutin can be decreased when it is combined with Deferasirox.Approved, Investigational
DeflazacortThe metabolism of Deflazacort can be increased when combined with Rifabutin.Approved
DelavirdineThe metabolism of Delavirdine can be increased when combined with Rifabutin.Approved
DesogestrelThe serum concentration of Desogestrel can be decreased when it is combined with Rifabutin.Approved
DesoximetasoneThe serum concentration of Desoximetasone can be decreased when it is combined with Rifabutin.Approved
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be decreased when it is combined with Rifabutin.Approved
Desoxycorticosterone PivalateThe serum concentration of Desoxycorticosterone Pivalate can be decreased when it is combined with Rifabutin.Experimental, Vet Approved
DesvenlafaxineThe metabolism of Desvenlafaxine can be increased when combined with Rifabutin.Approved
DeutetrabenazineThe metabolism of Deutetrabenazine can be increased when combined with Rifabutin.Approved, Investigational
DexamethasoneThe serum concentration of Dexamethasone can be decreased when it is combined with Rifabutin.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be decreased when it is combined with Rifabutin.Vet Approved
Dexchlorpheniramine maleateThe metabolism of Dexchlorpheniramine maleate can be increased when combined with Rifabutin.Approved
DexlansoprazoleThe metabolism of Dexlansoprazole can be increased when combined with Rifabutin.Approved
DextromethorphanThe metabolism of Dextromethorphan can be increased when combined with Rifabutin.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be increased when combined with Rifabutin.Approved, Illicit, Investigational, Withdrawn
DiazepamThe metabolism of Diazepam can be increased when combined with Rifabutin.Approved, Illicit, Vet Approved
DichloropheneThe serum concentration of Rifabutin can be increased when it is combined with Dichlorophene.Vet Approved
DiclofenacThe metabolism of Diclofenac can be increased when combined with Rifabutin.Approved, Vet Approved
DicoumarolThe metabolism of Dicoumarol can be increased when combined with Rifabutin.Approved
DienestrolThe serum concentration of Dienestrol can be decreased when it is combined with Rifabutin.Approved, Investigational
DienogestThe serum concentration of Dienogest can be decreased when it is combined with Rifabutin.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Rifabutin.Approved, Investigational
DiflorasoneThe serum concentration of Diflorasone can be decreased when it is combined with Rifabutin.Approved
DifluocortoloneThe serum concentration of Difluocortolone can be decreased when it is combined with Rifabutin.Approved, Investigational
DifluprednateThe serum concentration of Difluprednate can be decreased when it is combined with Rifabutin.Approved
DigitoxinThe metabolism of Digitoxin can be increased when combined with Rifabutin.Approved, Investigational
DigoxinThe metabolism of Digoxin can be increased when combined with Rifabutin.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be increased when combined with Rifabutin.Approved, Illicit
DihydroergotamineThe metabolism of Dihydroergotamine can be increased when combined with Rifabutin.Approved
DiltiazemThe metabolism of Diltiazem can be increased when combined with Rifabutin.Approved
DiphenadioneThe metabolism of Diphenadione can be increased when combined with Rifabutin.Experimental
DisopyramideThe metabolism of Disopyramide can be increased when combined with Rifabutin.Approved
DisulfiramThe metabolism of Disulfiram can be increased when combined with Rifabutin.Approved
DocetaxelThe metabolism of Docetaxel can be increased when combined with Rifabutin.Approved, Investigational
DofetilideThe metabolism of Dofetilide can be increased when combined with Rifabutin.Approved
DolasetronThe metabolism of Dolasetron can be increased when combined with Rifabutin.Approved
DomperidoneThe metabolism of Domperidone can be increased when combined with Rifabutin.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be increased when combined with Rifabutin.Approved
DorzolamideThe metabolism of Dorzolamide can be increased when combined with Rifabutin.Approved
DosulepinThe metabolism of Rifabutin can be decreased when combined with Dosulepin.Approved
DotarizineThe serum concentration of Dotarizine can be decreased when it is combined with Rifabutin.Investigational
DoxepinThe metabolism of Doxepin can be increased when combined with Rifabutin.Approved
DoxorubicinThe serum concentration of Doxorubicin can be decreased when it is combined with Rifabutin.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be increased when combined with Rifabutin.Approved, Investigational
DoxycyclineThe metabolism of Rifabutin can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be decreased when it is combined with Rifabutin.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be decreased when it is combined with Rifabutin.Approved
DrospirenoneThe serum concentration of Drospirenone can be decreased when it is combined with Rifabutin.Approved
DutasterideThe metabolism of Dutasteride can be increased when combined with Rifabutin.Approved, Investigational
EconazoleThe serum concentration of Rifabutin can be increased when it is combined with Econazole.Approved
EfavirenzThe serum concentration of Rifabutin can be decreased when it is combined with Efavirenz.Approved, Investigational
EfinaconazoleThe serum concentration of Rifabutin can be increased when it is combined with Efinaconazole.Approved
EfonidipineThe serum concentration of Efonidipine can be decreased when it is combined with Rifabutin.Approved
ElbasvirThe metabolism of Elbasvir can be increased when combined with Rifabutin.Approved
EletriptanThe metabolism of Eletriptan can be increased when combined with Rifabutin.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be decreased when it is combined with Rifabutin.Approved
ElvitegravirThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Elvitegravir.Approved
EnalaprilThe metabolism of Enalapril can be increased when combined with Rifabutin.Approved, Vet Approved
EnasidenibThe metabolism of Enasidenib can be increased when combined with Rifabutin.Approved
EperisoneThe serum concentration of Eperisone can be decreased when it is combined with Rifabutin.Approved, Investigational
EpinastineThe metabolism of Epinastine can be increased when combined with Rifabutin.Approved, Investigational
EplerenoneThe metabolism of Eplerenone can be increased when combined with Rifabutin.Approved
EquileninThe serum concentration of Equilenin can be decreased when it is combined with Rifabutin.Experimental
EquilinThe serum concentration of Equilin can be decreased when it is combined with Rifabutin.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be increased when combined with Rifabutin.Approved, Nutraceutical
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be increased when combined with Rifabutin.Approved
ErgonovineThe metabolism of Ergonovine can be increased when combined with Rifabutin.Approved
ErgotamineThe metabolism of Ergotamine can be increased when combined with Rifabutin.Approved
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Rifabutin.Approved, Investigational
ErythromycinThe metabolism of Erythromycin can be increased when combined with Rifabutin.Approved, Vet Approved
EscitalopramThe metabolism of Escitalopram can be increased when combined with Rifabutin.Approved, Investigational
EsomeprazoleThe metabolism of Esomeprazole can be increased when combined with Rifabutin.Approved, Investigational
EstazolamThe metabolism of Estazolam can be increased when combined with Rifabutin.Approved, Illicit
EstradiolThe metabolism of Estradiol can be increased when combined with Rifabutin.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be increased when combined with Rifabutin.Approved, Investigational
EstramustineThe metabolism of Estramustine can be increased when combined with Rifabutin.Approved
Estrogens, esterifiedThe serum concentration of Estrogens, esterified can be decreased when it is combined with Rifabutin.Approved
EstroneThe metabolism of Estrone can be increased when combined with Rifabutin.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be increased when combined with Rifabutin.Approved
EszopicloneThe metabolism of Eszopiclone can be increased when combined with Rifabutin.Approved
EthanolThe metabolism of Ethanol can be increased when combined with Rifabutin.Approved
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be increased when combined with Rifabutin.Approved
EthosuximideThe metabolism of Ethosuximide can be increased when combined with Rifabutin.Approved
Ethyl biscoumacetateThe metabolism of Ethyl biscoumacetate can be increased when combined with Rifabutin.Withdrawn
EthylmorphineThe metabolism of Ethylmorphine can be increased when combined with Rifabutin.Approved, Illicit
Ethynodiol diacetateThe serum concentration of Ethynodiol diacetate can be decreased when it is combined with Rifabutin.Approved
EtizolamThe metabolism of Etizolam can be increased when combined with Rifabutin.Approved
EtonogestrelThe metabolism of Etonogestrel can be increased when combined with Rifabutin.Approved, Investigational
EtoposideThe serum concentration of Etoposide can be decreased when it is combined with Rifabutin.Approved
EtoricoxibThe metabolism of Etoricoxib can be increased when combined with Rifabutin.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Rifabutin.Approved
EverolimusThe serum concentration of Everolimus can be decreased when it is combined with Rifabutin.Approved
ExemestaneThe serum concentration of Exemestane can be decreased when it is combined with Rifabutin.Approved, Investigational
FamciclovirThe metabolism of Famciclovir can be increased when combined with Rifabutin.Approved
FelbamateThe metabolism of Felbamate can be increased when combined with Rifabutin.Approved
FelodipineThe metabolism of Felodipine can be increased when combined with Rifabutin.Approved, Investigational
FendilineThe serum concentration of Fendiline can be decreased when it is combined with Rifabutin.Withdrawn
FenofibrateThe metabolism of Fenofibrate can be increased when combined with Rifabutin.Approved
FentanylThe serum concentration of Fentanyl can be decreased when it is combined with Rifabutin.Approved, Illicit, Investigational, Vet Approved
FenticonazoleThe serum concentration of Rifabutin can be increased when it is combined with Fenticonazole.Experimental
FesoterodineThe metabolism of Fesoterodine can be increased when combined with Rifabutin.Approved
FinasterideThe metabolism of Finasteride can be increased when combined with Rifabutin.Approved
FingolimodThe metabolism of Fingolimod can be increased when combined with Rifabutin.Approved, Investigational
FlibanserinThe serum concentration of Flibanserin can be decreased when it is combined with Rifabutin.Approved
fluasteroneThe serum concentration of fluasterone can be decreased when it is combined with Rifabutin.Investigational
FluconazoleThe serum concentration of Rifabutin can be increased when it is combined with Fluconazole.Approved
FlucytosineThe serum concentration of Rifabutin can be increased when it is combined with Flucytosine.Approved
FludrocortisoneThe serum concentration of Fludrocortisone can be decreased when it is combined with Rifabutin.Approved
FluindioneThe metabolism of Fluindione can be increased when combined with Rifabutin.Investigational
FlumethasoneThe serum concentration of Flumethasone can be decreased when it is combined with Rifabutin.Approved, Vet Approved
FlunarizineThe serum concentration of Flunarizine can be decreased when it is combined with Rifabutin.Approved
FlunisolideThe metabolism of Flunisolide can be increased when combined with Rifabutin.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be increased when combined with Rifabutin.Approved, Illicit
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be decreased when it is combined with Rifabutin.Approved, Investigational, Vet Approved
FluocinonideThe serum concentration of Fluocinonide can be decreased when it is combined with Rifabutin.Approved, Investigational
FluocortoloneThe serum concentration of Fluocortolone can be decreased when it is combined with Rifabutin.Approved, Withdrawn
FluorometholoneThe metabolism of Fluorometholone can be increased when combined with Rifabutin.Approved
FluoxetineThe metabolism of Fluoxetine can be increased when combined with Rifabutin.Approved, Vet Approved
FluprednideneThe serum concentration of Fluprednidene can be decreased when it is combined with Rifabutin.Approved, Withdrawn
FluprednisoloneThe serum concentration of Fluprednisolone can be decreased when it is combined with Rifabutin.Approved
FlurandrenolideThe serum concentration of Flurandrenolide can be decreased when it is combined with Rifabutin.Approved
FlurazepamThe metabolism of Flurazepam can be increased when combined with Rifabutin.Approved, Illicit
FlutamideThe metabolism of Flutamide can be increased when combined with Rifabutin.Approved
Fluticasone furoateThe metabolism of Fluticasone furoate can be increased when combined with Rifabutin.Approved
Fluticasone propionateThe metabolism of Fluticasone propionate can be increased when combined with Rifabutin.Approved
FlutrimazoleThe serum concentration of Rifabutin can be increased when it is combined with Flutrimazole.Experimental
FluvastatinThe metabolism of Fluvastatin can be increased when combined with Rifabutin.Approved
FluvoxamineThe metabolism of Rifabutin can be decreased when combined with Fluvoxamine.Approved, Investigational
FormestaneThe serum concentration of Formestane can be decreased when it is combined with Rifabutin.Approved, Investigational, Withdrawn
FosamprenavirThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Rifabutin can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe metabolism of Rifabutin can be increased when combined with Fosphenytoin.Approved
FulvestrantThe metabolism of Fulvestrant can be increased when combined with Rifabutin.Approved, Investigational
Fusidic AcidThe serum concentration of Rifabutin can be increased when it is combined with Fusidic Acid.Approved
GabapentinThe serum concentration of Gabapentin can be decreased when it is combined with Rifabutin.Approved, Investigational
GalantamineThe metabolism of Galantamine can be increased when combined with Rifabutin.Approved
GallopamilThe serum concentration of Gallopamil can be decreased when it is combined with Rifabutin.Investigational
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Rifabutin.Approved, Investigational
GemfibrozilThe metabolism of Gemfibrozil can be increased when combined with Rifabutin.Approved
GestodeneThe serum concentration of Gestodene can be decreased when it is combined with Rifabutin.Approved, Investigational
GlipizideThe metabolism of Glipizide can be increased when combined with Rifabutin.Approved
GlyburideThe metabolism of Glyburide can be increased when combined with Rifabutin.Approved
GlyphosateThe serum concentration of Rifabutin can be increased when it is combined with Glyphosate.Experimental
GranisetronThe metabolism of Granisetron can be increased when combined with Rifabutin.Approved, Investigational
GrazoprevirThe metabolism of Grazoprevir can be increased when combined with Rifabutin.Approved
GrepafloxacinThe metabolism of Grepafloxacin can be increased when combined with Rifabutin.Investigational, Withdrawn
GriseofulvinThe serum concentration of Rifabutin can be increased when it is combined with Griseofulvin.Approved, Vet Approved
GuanfacineThe serum concentration of Guanfacine can be decreased when it is combined with Rifabutin.Approved, Investigational
HachimycinThe serum concentration of Rifabutin can be increased when it is combined with Hachimycin.Experimental
HalofantrineThe metabolism of Halofantrine can be increased when combined with Rifabutin.Approved
HaloperidolThe metabolism of Haloperidol can be increased when combined with Rifabutin.Approved
HaloproginThe serum concentration of Rifabutin can be increased when it is combined with Haloprogin.Approved, Withdrawn
HalothaneThe metabolism of Halothane can be increased when combined with Rifabutin.Approved, Vet Approved
HE3286The serum concentration of HE3286 can be decreased when it is combined with Rifabutin.Investigational
HexestrolThe serum concentration of Hexestrol can be decreased when it is combined with Rifabutin.Withdrawn
HexetidineThe serum concentration of Rifabutin can be increased when it is combined with Hexetidine.Approved, Investigational
HexobarbitalThe metabolism of Hexobarbital can be increased when combined with Rifabutin.Approved
HistamineThe metabolism of Histamine can be increased when combined with Rifabutin.Approved, Investigational
HydrocodoneThe serum concentration of Hydrocodone can be decreased when it is combined with Rifabutin.Approved, Illicit
HydrocortisoneThe serum concentration of Hydrocortisone can be decreased when it is combined with Rifabutin.Approved, Vet Approved
HydromorphoneThe metabolism of Hydromorphone can be increased when combined with Rifabutin.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be increased when combined with Rifabutin.Approved
IbrutinibThe serum concentration of Ibrutinib can be decreased when it is combined with Rifabutin.Approved
IcotinibThe metabolism of Icotinib can be increased when combined with Rifabutin.Approved, Investigational
IdelalisibThe serum concentration of Rifabutin can be increased when it is combined with Idelalisib.Approved
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be increased when Ifosfamide is used in combination with Rifabutin.Approved
IloperidoneThe metabolism of Iloperidone can be increased when combined with Rifabutin.Approved
ImatinibThe serum concentration of Imatinib can be decreased when it is combined with Rifabutin.Approved
ImidafenacinThe metabolism of Imidafenacin can be increased when combined with Rifabutin.Approved, Investigational
ImipramineThe metabolism of Imipramine can be increased when combined with Rifabutin.Approved
ImiquimodThe metabolism of Imiquimod can be increased when combined with Rifabutin.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be increased when combined with Rifabutin.Approved
IndapamideThe metabolism of Indapamide can be increased when combined with Rifabutin.Approved
IndinavirThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Indinavir.Approved
Ipratropium bromideThe metabolism of Ipratropium bromide can be increased when combined with Rifabutin.Approved
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be reduced when Irinotecan is used in combination with Rifabutin resulting in a loss in efficacy.Approved, Investigational
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Rifabutin resulting in a loss in efficacy.Approved, Investigational
IsoconazoleThe serum concentration of Rifabutin can be increased when it is combined with Isoconazole.Approved
IsoniazidRifabutin may increase the hepatotoxic activities of Isoniazid.Approved
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be increased when combined with Rifabutin.Approved
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be increased when combined with Rifabutin.Approved
IsradipineThe metabolism of Isradipine can be increased when combined with Rifabutin.Approved
IstaroximeThe serum concentration of Istaroxime can be decreased when it is combined with Rifabutin.Investigational
ItraconazoleThe serum concentration of Itraconazole can be decreased when it is combined with Rifabutin.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be decreased when it is combined with Rifabutin.Approved
IvacaftorThe serum concentration of Rifabutin can be increased when it is combined with Ivacaftor.Approved
IvermectinThe metabolism of Ivermectin can be increased when combined with Rifabutin.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be decreased when it is combined with Rifabutin.Approved, Investigational
IxazomibThe serum concentration of Ixazomib can be decreased when it is combined with Rifabutin.Approved
JosamycinThe metabolism of Rifabutin can be decreased when combined with Josamycin.Approved, Investigational
KetamineThe metabolism of Ketamine can be increased when combined with Rifabutin.Approved, Vet Approved
KetazolamThe metabolism of Ketazolam can be increased when combined with Rifabutin.Approved
KetobemidoneThe metabolism of Ketobemidone can be increased when combined with Rifabutin.Approved, Investigational
KetoconazoleThe metabolism of Ketoconazole can be increased when combined with Rifabutin.Approved, Investigational
KitasamycinThe metabolism of Rifabutin can be decreased when combined with Kitasamycin.Experimental
LacidipineThe serum concentration of Lacidipine can be decreased when it is combined with Rifabutin.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be decreased when it is combined with Rifabutin.Approved, Investigational
LansoprazoleThe metabolism of Lansoprazole can be increased when combined with Rifabutin.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be decreased when it is combined with Rifabutin.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be increased when combined with Rifabutin.Investigational
LedipasvirThe serum concentration of Ledipasvir can be decreased when it is combined with Rifabutin.Approved
LenvatinibThe metabolism of Lenvatinib can be increased when combined with Rifabutin.Approved
LercanidipineThe metabolism of Lercanidipine can be increased when combined with Rifabutin.Approved, Investigational
LetrozoleThe metabolism of Letrozole can be increased when combined with Rifabutin.Approved, Investigational
LevobupivacaineThe metabolism of Levobupivacaine can be increased when combined with Rifabutin.Approved, Investigational
LevocetirizineThe metabolism of Levocetirizine can be increased when combined with Rifabutin.Approved
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be increased when combined with Rifabutin.Approved, Investigational
LevomilnacipranThe metabolism of Levomilnacipran can be increased when combined with Rifabutin.Approved
LevonorgestrelThe metabolism of Levonorgestrel can be increased when combined with Rifabutin.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be increased when combined with Rifabutin.Approved
LidocaineThe metabolism of Lidocaine can be increased when combined with Rifabutin.Approved, Vet Approved
LidoflazineThe serum concentration of Lidoflazine can be decreased when it is combined with Rifabutin.Experimental
LinagliptinThe serum concentration of Linagliptin can be decreased when it is combined with Rifabutin.Approved
LisurideThe metabolism of Lisuride can be increased when combined with Rifabutin.Approved, Investigational
LobeglitazoneThe metabolism of Rifabutin can be decreased when combined with Lobeglitazone.Approved, Investigational
LomitapideThe metabolism of Lomitapide can be increased when combined with Rifabutin.Approved
LoperamideThe metabolism of Loperamide can be increased when combined with Rifabutin.Approved
LopinavirThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Lopinavir.Approved
LoratadineThe metabolism of Loratadine can be increased when combined with Rifabutin.Approved
LorcaserinThe metabolism of Lorcaserin can be increased when combined with Rifabutin.Approved
LosartanThe metabolism of Losartan can be increased when combined with Rifabutin.Approved
LovastatinThe metabolism of Lovastatin can be increased when combined with Rifabutin.Approved, Investigational
LuliconazoleThe serum concentration of Rifabutin can be increased when it is combined with Luliconazole.Approved
LumacaftorThe metabolism of Rifabutin can be increased when combined with Lumacaftor.Approved
LumefantrineThe serum concentration of Lumefantrine can be decreased when it is combined with Rifabutin.Approved
LurasidoneThe serum concentration of Lurasidone can be decreased when it is combined with Rifabutin.Approved
LynestrenolThe serum concentration of Lynestrenol can be decreased when it is combined with Rifabutin.Investigational
MacitentanThe serum concentration of Macitentan can be decreased when it is combined with Rifabutin.Approved
Magnesium SulfateThe serum concentration of Magnesium Sulfate can be decreased when it is combined with Rifabutin.Approved, Vet Approved
ManidipineThe serum concentration of Manidipine can be decreased when it is combined with Rifabutin.Approved, Investigational
MaravirocThe serum concentration of Maraviroc can be decreased when it is combined with Rifabutin.Approved, Investigational
ME-609The serum concentration of ME-609 can be decreased when it is combined with Rifabutin.Investigational
MebendazoleThe metabolism of Mebendazole can be increased when combined with Rifabutin.Approved, Vet Approved
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be increased when combined with Rifabutin.Approved, Investigational
MedrysoneThe serum concentration of Medrysone can be decreased when it is combined with Rifabutin.Approved
MefloquineThe metabolism of Mefloquine can be increased when combined with Rifabutin.Approved
MelengestrolThe serum concentration of Melengestrol can be decreased when it is combined with Rifabutin.Vet Approved
MeloxicamThe metabolism of Meloxicam can be increased when combined with Rifabutin.Approved, Vet Approved
MepartricinThe serum concentration of Rifabutin can be increased when it is combined with Mepartricin.Experimental
MestranolThe serum concentration of Mestranol can be decreased when it is combined with Rifabutin.Approved
MethadoneThe serum concentration of Methadone can be decreased when it is combined with Rifabutin.Approved
MethallenestrilThe serum concentration of Methallenestril can be decreased when it is combined with Rifabutin.Experimental
MethaqualoneThe metabolism of Methaqualone can be increased when combined with Rifabutin.Illicit, Withdrawn
MethohexitalThe metabolism of Methohexital can be increased when combined with Rifabutin.Approved
MethoxsalenThe metabolism of Methoxsalen can be increased when combined with Rifabutin.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be increased when combined with Rifabutin.Approved, Investigational, Vet Approved
Methyl salicylateThe metabolism of Methyl salicylate can be increased when combined with Rifabutin.Approved, Vet Approved
MethylphenobarbitalThe metabolism of Methylphenobarbital can be increased when combined with Rifabutin.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be decreased when it is combined with Rifabutin.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be increased when combined with Rifabutin.Approved
MetronidazoleThe metabolism of Metronidazole can be increased when combined with Rifabutin.Approved
MevastatinThe serum concentration of Mevastatin can be decreased when it is combined with Rifabutin.Experimental
MexiletineThe metabolism of Mexiletine can be increased when combined with Rifabutin.Approved
MianserinThe metabolism of Mianserin can be increased when combined with Rifabutin.Approved, Investigational
MibefradilThe metabolism of Mibefradil can be increased when combined with Rifabutin.Investigational, Withdrawn
MicafunginThe serum concentration of Rifabutin can be increased when it is combined with Micafungin.Approved, Investigational
MiconazoleThe metabolism of Miconazole can be increased when combined with Rifabutin.Approved, Investigational, Vet Approved
MidazolamThe metabolism of Midazolam can be increased when combined with Rifabutin.Approved, Illicit
MidostaurinThe metabolism of Midostaurin can be increased when combined with Rifabutin.Approved
MifepristoneThe serum concentration of Rifabutin can be increased when it is combined with Mifepristone.Approved, Investigational
MiltefosineThe serum concentration of Rifabutin can be increased when it is combined with Miltefosine.Approved
MirabegronThe metabolism of Mirabegron can be increased when combined with Rifabutin.Approved
MirtazapineThe metabolism of Mirtazapine can be increased when combined with Rifabutin.Approved
MitotaneThe serum concentration of Rifabutin can be decreased when it is combined with Mitotane.Approved
ModafinilThe metabolism of Modafinil can be increased when combined with Rifabutin.Approved, Investigational
MonensinThe serum concentration of Rifabutin can be increased when it is combined with Monensin.Vet Approved
MontelukastThe metabolism of Montelukast can be increased when combined with Rifabutin.Approved
MorphineThe serum concentration of Morphine can be decreased when it is combined with Rifabutin.Approved, Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be increased when combined with Rifabutin.Approved, Investigational
Mycophenolic acidThe serum concentration of Mycophenolic acid can be decreased when it is combined with Rifabutin.Approved
MyxothiazolThe serum concentration of Rifabutin can be increased when it is combined with Myxothiazol.Experimental
NaftifineThe serum concentration of Rifabutin can be increased when it is combined with Naftifine.Approved
NaftopidilThe serum concentration of Naftopidil can be decreased when it is combined with Rifabutin.Investigational
NaloxegolThe serum concentration of Naloxegol can be decreased when it is combined with Rifabutin.Approved
NaloxoneThe metabolism of Naloxone can be increased when combined with Rifabutin.Approved, Vet Approved
NatamycinThe serum concentration of Rifabutin can be increased when it is combined with Natamycin.Approved
NateglinideThe metabolism of Nateglinide can be increased when combined with Rifabutin.Approved, Investigational
NCX 1022The serum concentration of NCX 1022 can be decreased when it is combined with Rifabutin.Investigational
NefazodoneThe metabolism of Nefazodone can be increased when combined with Rifabutin.Approved, Withdrawn
NelfinavirThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Nelfinavir.Approved
NeratinibThe metabolism of Neratinib can be increased when combined with Rifabutin.Approved, Investigational
NetupitantThe serum concentration of Rifabutin can be increased when it is combined with Netupitant.Approved
NevirapineThe serum concentration of Nevirapine can be decreased when it is combined with Rifabutin.Approved
NicardipineThe metabolism of Nicardipine can be increased when combined with Rifabutin.Approved
NicotineThe metabolism of Nicotine can be increased when combined with Rifabutin.Approved
NifedipineThe serum concentration of Nifedipine can be decreased when it is combined with Rifabutin.Approved
NifuratelThe serum concentration of Rifabutin can be increased when it is combined with Nifuratel.Experimental
NiguldipineThe serum concentration of Niguldipine can be decreased when it is combined with Rifabutin.Experimental
Nikkomycin ZThe serum concentration of Rifabutin can be increased when it is combined with Nikkomycin Z.Investigational
NilotinibThe serum concentration of Nilotinib can be decreased when it is combined with Rifabutin.Approved, Investigational
NiludipineThe serum concentration of Niludipine can be decreased when it is combined with Rifabutin.Experimental
NilvadipineThe metabolism of Nilvadipine can be increased when combined with Rifabutin.Approved, Investigational
NimesulideThe serum concentration of Nimesulide can be decreased when it is combined with Rifabutin.Approved, Investigational, Withdrawn
NimodipineThe serum concentration of Nimodipine can be decreased when it is combined with Rifabutin.Approved
NisoldipineThe serum concentration of Nisoldipine can be decreased when it is combined with Rifabutin.Approved
NitrazepamThe metabolism of Nitrazepam can be increased when combined with Rifabutin.Approved
NitrendipineThe metabolism of Nitrendipine can be increased when combined with Rifabutin.Approved, Investigational
NitroxolineThe serum concentration of Rifabutin can be increased when it is combined with Nitroxoline.Approved
NorelgestrominThe serum concentration of Norelgestromin can be decreased when it is combined with Rifabutin.Approved
NorethisteroneThe metabolism of Norethisterone can be increased when combined with Rifabutin.Approved
NorgestimateThe serum concentration of Norgestimate can be decreased when it is combined with Rifabutin.Approved
NorgestrelThe metabolism of Norgestrel can be increased when combined with Rifabutin.Approved
NortriptylineThe metabolism of Nortriptyline can be increased when combined with Rifabutin.Approved
NystatinThe serum concentration of Rifabutin can be increased when it is combined with Nystatin.Approved, Vet Approved
OdanacatibThe metabolism of Odanacatib can be increased when combined with Rifabutin.Investigational
OlaparibThe serum concentration of Olaparib can be decreased when it is combined with Rifabutin.Approved
OleandomycinThe metabolism of Rifabutin can be decreased when combined with Oleandomycin.Vet Approved
Oleoyl-estroneThe serum concentration of Oleoyl-estrone can be decreased when it is combined with Rifabutin.Investigational
OlopatadineThe metabolism of Olopatadine can be increased when combined with Rifabutin.Approved
OmeprazoleThe metabolism of Omeprazole can be increased when combined with Rifabutin.Approved, Investigational, Vet Approved
OmoconazoleThe serum concentration of Rifabutin can be increased when it is combined with Omoconazole.Experimental
OndansetronThe metabolism of Ondansetron can be increased when combined with Rifabutin.Approved
OrphenadrineThe metabolism of Orphenadrine can be increased when combined with Rifabutin.Approved
OsimertinibThe serum concentration of Rifabutin can be increased when it is combined with Osimertinib.Approved
OspemifeneThe metabolism of Ospemifene can be increased when combined with Rifabutin.Approved
OtiloniumThe serum concentration of Otilonium can be decreased when it is combined with Rifabutin.Experimental, Investigational
OxazepamThe metabolism of Oxazepam can be increased when combined with Rifabutin.Approved
OxiconazoleThe serum concentration of Rifabutin can be increased when it is combined with Oxiconazole.Approved
OxybutyninThe metabolism of Oxybutynin can be increased when combined with Rifabutin.Approved, Investigational
OxycodoneThe metabolism of Oxycodone can be increased when combined with Rifabutin.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be increased when combined with Rifabutin.Approved, Investigational, Vet Approved
PaclitaxelThe metabolism of Paclitaxel can be increased when combined with Rifabutin.Approved, Vet Approved
pafuramidineThe serum concentration of Rifabutin can be increased when it is combined with pafuramidine.Investigational
PalbociclibThe serum concentration of Rifabutin can be increased when it is combined with Palbociclib.Approved
PalonosetronThe metabolism of Palonosetron can be increased when combined with Rifabutin.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be decreased when it is combined with Rifabutin.Approved, Investigational
PantoprazoleThe metabolism of Pantoprazole can be increased when combined with Rifabutin.Approved
ParamethadioneThe metabolism of Paramethadione can be increased when combined with Rifabutin.Approved
ParamethasoneThe metabolism of Paramethasone can be increased when combined with Rifabutin.Approved
ParecoxibThe metabolism of Parecoxib can be increased when combined with Rifabutin.Approved
ParicalcitolThe metabolism of Paricalcitol can be increased when combined with Rifabutin.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be increased when combined with Rifabutin.Approved
PazopanibThe serum concentration of Pazopanib can be decreased when it is combined with Rifabutin.Approved
Peginterferon alfa-2bThe serum concentration of Rifabutin can be increased when it is combined with Peginterferon alfa-2b.Approved
PentamidineThe metabolism of Pentamidine can be increased when combined with Rifabutin.Approved
PentobarbitalThe metabolism of Rifabutin can be increased when combined with Pentobarbital.Approved, Vet Approved
PerampanelThe serum concentration of Perampanel can be decreased when it is combined with Rifabutin.Approved
PergolideThe metabolism of Pergolide can be increased when combined with Rifabutin.Approved, Investigational, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be increased when combined with Rifabutin.Approved, Investigational
PermethrinThe metabolism of Permethrin can be increased when combined with Rifabutin.Approved, Investigational
PerospironeThe metabolism of Perospirone can be increased when combined with Rifabutin.Approved
PerphenazineThe metabolism of Perphenazine can be increased when combined with Rifabutin.Approved
PethidineThe metabolism of Pethidine can be increased when combined with Rifabutin.Approved
PhenacetinThe metabolism of Phenacetin can be increased when combined with Rifabutin.Withdrawn
PhenindioneThe metabolism of Phenindione can be increased when combined with Rifabutin.Approved, Investigational
PhenobarbitalThe metabolism of Rifabutin can be increased when combined with Phenobarbital.Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be increased when combined with Rifabutin.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be increased when combined with Rifabutin.Approved, Investigational
PhenytoinThe metabolism of Rifabutin can be increased when combined with Phenytoin.Approved, Vet Approved
Picosulfuric acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Rifabutin.Approved
PilocarpineThe metabolism of Pilocarpine can be increased when combined with Rifabutin.Approved
PimecrolimusThe metabolism of Pimecrolimus can be increased when combined with Rifabutin.Approved, Investigational
PimozideThe metabolism of Pimozide can be increased when combined with Rifabutin.Approved
PinacidilThe metabolism of Pinacidil can be increased when combined with Rifabutin.Withdrawn
PinaveriumThe serum concentration of Pinaverium can be decreased when it is combined with Rifabutin.Approved
PioglitazoneThe metabolism of Pioglitazone can be increased when combined with Rifabutin.Approved, Investigational
PipotiazineThe metabolism of Pipotiazine can be increased when combined with Rifabutin.Approved, Investigational
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Rifabutin.Approved
PodofiloxThe metabolism of Podofilox can be increased when combined with Rifabutin.Approved
PomalidomideThe metabolism of Pomalidomide can be increased when combined with Rifabutin.Approved
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with Rifabutin.Approved
PosaconazoleThe metabolism of Posaconazole can be increased when combined with Rifabutin.Approved, Investigational, Vet Approved
PrasteroneThe metabolism of Prasterone can be increased when combined with Rifabutin.Approved, Nutraceutical
Prasterone sulfateThe serum concentration of Prasterone sulfate can be decreased when it is combined with Rifabutin.Investigational
PrasugrelThe metabolism of Prasugrel can be increased when combined with Rifabutin.Approved
PravastatinThe metabolism of Pravastatin can be increased when combined with Rifabutin.Approved
PrazepamThe metabolism of Prazepam can be increased when combined with Rifabutin.Approved, Illicit
PraziquantelThe serum concentration of Praziquantel can be decreased when it is combined with Rifabutin.Approved, Vet Approved
PrednicarbateThe serum concentration of Prednicarbate can be decreased when it is combined with Rifabutin.Approved
PrednisoloneThe serum concentration of Prednisolone can be decreased when it is combined with Rifabutin.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be decreased when it is combined with Rifabutin.Approved, Vet Approved
PregabalinThe serum concentration of Pregabalin can be decreased when it is combined with Rifabutin.Approved, Illicit, Investigational
PregnenoloneThe serum concentration of Pregnenolone can be decreased when it is combined with Rifabutin.Experimental, Investigational
PrenylamineThe serum concentration of Prenylamine can be decreased when it is combined with Rifabutin.Withdrawn
PrimaquineThe metabolism of Primaquine can be increased when combined with Rifabutin.Approved
PrimidoneThe metabolism of Rifabutin can be increased when combined with Primidone.Approved, Vet Approved
ProchlorperazineThe metabolism of Prochlorperazine can be increased when combined with Rifabutin.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be increased when combined with Rifabutin.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be increased when combined with Rifabutin.Approved
PromazineThe metabolism of Promazine can be increased when combined with Rifabutin.Approved, Vet Approved
PropafenoneThe serum concentration of Propafenone can be decreased when it is combined with Rifabutin.Approved
PropofolThe metabolism of Propofol can be increased when combined with Rifabutin.Approved, Investigational, Vet Approved
Propoxyphene napsylateThe metabolism of Propoxyphene napsylate can be increased when combined with Rifabutin.Approved
PropranololThe metabolism of Propranolol can be increased when combined with Rifabutin.Approved, Investigational
PyrazinamideThe metabolism of Pyrazinamide can be increased when combined with Rifabutin.Approved
PyrrolnitrinThe serum concentration of Rifabutin can be increased when it is combined with Pyrrolnitrin.Experimental
QuazepamThe metabolism of Quazepam can be increased when combined with Rifabutin.Approved, Illicit
QuetiapineThe serum concentration of Quetiapine can be decreased when it is combined with Rifabutin.Approved
QuinacrineThe metabolism of Quinacrine can be increased when combined with Rifabutin.Approved, Investigational
QuinidineThe serum concentration of Quinidine can be decreased when it is combined with Rifabutin.Approved
QuinineThe metabolism of Quinine can be increased when combined with Rifabutin.Approved
RabeprazoleThe metabolism of Rabeprazole can be increased when combined with Rifabutin.Approved, Investigational
RadicicolThe serum concentration of Rifabutin can be increased when it is combined with Radicicol.Experimental
RaloxifeneThe metabolism of Raloxifene can be increased when combined with Rifabutin.Approved, Investigational
RaltegravirThe serum concentration of Raltegravir can be decreased when it is combined with Rifabutin.Approved
RamelteonThe metabolism of Ramelteon can be increased when combined with Rifabutin.Approved, Investigational
RanolazineThe serum concentration of Ranolazine can be decreased when it is combined with Rifabutin.Approved, Investigational
ReboxetineThe metabolism of Reboxetine can be increased when combined with Rifabutin.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be decreased when it is combined with Rifabutin.Approved
RepaglinideThe metabolism of Repaglinide can be increased when combined with Rifabutin.Approved, Investigational
RetapamulinThe metabolism of Retapamulin can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Rifampicin can be increased when combined with Rifabutin.Approved
RifapentineThe metabolism of Rifabutin can be increased when combined with Rifapentine.Approved
RilpivirineThe serum concentration of Rilpivirine can be decreased when it is combined with Rifabutin.Approved
RimexoloneThe serum concentration of Rimexolone can be decreased when it is combined with Rifabutin.Approved
RimonabantThe metabolism of Rimonabant can be increased when combined with Rifabutin.Approved, Investigational
RiociguatThe metabolism of Riociguat can be increased when combined with Rifabutin.Approved
RisedronateThe serum concentration of Risedronate can be decreased when it is combined with Rifabutin.Approved, Investigational
RisperidoneThe metabolism of Risperidone can be increased when combined with Rifabutin.Approved, Investigational
RitonavirThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Ritonavir.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be decreased when it is combined with Rifabutin.Approved
RofecoxibThe metabolism of Rofecoxib can be increased when combined with Rifabutin.Investigational, Withdrawn
RoflumilastThe serum concentration of Roflumilast can be decreased when it is combined with Rifabutin.Approved
RolapitantThe serum concentration of Rolapitant can be decreased when it is combined with Rifabutin.Approved
RomidepsinThe serum concentration of Romidepsin can be decreased when it is combined with Rifabutin.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be increased when combined with Rifabutin.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be increased when combined with Rifabutin.Approved
RosuvastatinThe metabolism of Rosuvastatin can be increased when combined with Rifabutin.Approved
RotigotineThe metabolism of Rotigotine can be increased when combined with Rifabutin.Approved
RoxithromycinThe metabolism of Roxithromycin can be increased when combined with Rifabutin.Approved, Investigational, Withdrawn
RucaparibThe metabolism of Rucaparib can be increased when combined with Rifabutin.Approved, Investigational
RupatadineThe metabolism of Rupatadine can be increased when combined with Rifabutin.Approved
RuxolitinibThe metabolism of Ruxolitinib can be increased when combined with Rifabutin.Approved
SafinamideThe metabolism of Safinamide can be increased when combined with Rifabutin.Approved
Salicylhydroxamic AcidThe serum concentration of Rifabutin can be increased when it is combined with Salicylhydroxamic Acid.Experimental
Salicylic acidThe serum concentration of Rifabutin can be increased when it is combined with Salicylic acid.Approved, Vet Approved
SalmeterolThe metabolism of Salmeterol can be increased when combined with Rifabutin.Approved
SaquinavirThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Saquinavir.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Rifabutin.Approved
SecobarbitalThe metabolism of Secobarbital can be increased when combined with Rifabutin.Approved, Vet Approved
SelegilineThe metabolism of Selegiline can be increased when combined with Rifabutin.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be increased when combined with Rifabutin.Approved
SeratrodastThe metabolism of Seratrodast can be increased when combined with Rifabutin.Approved
SertaconazoleThe serum concentration of Rifabutin can be increased when it is combined with Sertaconazole.Approved
SertindoleThe metabolism of Sertindole can be increased when combined with Rifabutin.Approved, Investigational, Withdrawn
SertralineThe metabolism of Sertraline can be increased when combined with Rifabutin.Approved
SevofluraneThe metabolism of Sevoflurane can be increased when combined with Rifabutin.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be increased when combined with Rifabutin.Approved, Illicit, Investigational, Withdrawn
SildenafilThe metabolism of Sildenafil can be increased when combined with Rifabutin.Approved, Investigational
SilodosinThe metabolism of Silodosin can be increased when combined with Rifabutin.Approved
SiltuximabThe serum concentration of Rifabutin can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Rifabutin can be increased when it is combined with Simeprevir.Approved
SimvastatinThe metabolism of Simvastatin can be increased when combined with Rifabutin.Approved
SinefunginThe serum concentration of Rifabutin can be increased when it is combined with Sinefungin.Experimental
SirolimusThe metabolism of Sirolimus can be increased when combined with Rifabutin.Approved, Investigational
SitagliptinThe metabolism of Sitagliptin can be increased when combined with Rifabutin.Approved, Investigational
SofosbuvirThe serum concentration of Sofosbuvir can be decreased when it is combined with Rifabutin.Approved
SolifenacinThe metabolism of Solifenacin can be increased when combined with Rifabutin.Approved
SolithromycinThe metabolism of Rifabutin can be decreased when combined with Solithromycin.Investigational
SonidegibThe serum concentration of Sonidegib can be decreased when it is combined with Rifabutin.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be decreased when it is combined with Rifabutin.Approved, Investigational
SpiramycinThe metabolism of Spiramycin can be increased when combined with Rifabutin.Approved
St. John's WortThe serum concentration of Rifabutin can be decreased when it is combined with St. John's Wort.Investigational, Nutraceutical
StiripentolThe serum concentration of Rifabutin can be increased when it is combined with Stiripentol.Approved
SufentanilThe metabolism of Sufentanil can be increased when combined with Rifabutin.Approved, Investigational
SulconazoleThe serum concentration of Rifabutin can be increased when it is combined with Sulconazole.Approved
SulfadiazineThe metabolism of Sulfadiazine can be increased when combined with Rifabutin.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be increased when combined with Rifabutin.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be increased when combined with Rifabutin.Approved
SulfisoxazoleThe metabolism of Rifabutin can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SunitinibThe serum concentration of Sunitinib can be decreased when it is combined with Rifabutin.Approved, Investigational
SuvorexantThe serum concentration of Suvorexant can be decreased when it is combined with Rifabutin.Approved
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be increased when combined with Rifabutin.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be increased when combined with Rifabutin.Approved
TacrolimusThe serum concentration of Tacrolimus can be decreased when it is combined with Rifabutin.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be decreased when it is combined with Rifabutin.Approved, Investigational
TamoxifenThe metabolism of Tamoxifen can be increased when combined with Rifabutin.Approved
TamsulosinThe metabolism of Tamsulosin can be increased when combined with Rifabutin.Approved, Investigational
TasimelteonThe serum concentration of Tasimelteon can be decreased when it is combined with Rifabutin.Approved
TasosartanThe metabolism of Tasosartan can be increased when combined with Rifabutin.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be increased when combined with Rifabutin.Experimental
TavaboroleThe serum concentration of Rifabutin can be increased when it is combined with Tavaborole.Approved
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Rifabutin.Approved, Withdrawn
TelithromycinThe metabolism of Telithromycin can be increased when combined with Rifabutin.Approved
TemazepamThe metabolism of Temazepam can be increased when combined with Rifabutin.Approved
TemsirolimusThe serum concentration of Temsirolimus can be decreased when it is combined with Rifabutin.Approved
TeniposideThe metabolism of Teniposide can be increased when combined with Rifabutin.Approved
Tenofovir disoproxilThe metabolism of Rifabutin can be decreased when combined with Tenofovir disoproxil.Approved, Investigational
TerbinafineThe metabolism of Terbinafine can be increased when combined with Rifabutin.Approved, Investigational, Vet Approved
TerconazoleThe serum concentration of Rifabutin can be increased when it is combined with Terconazole.Approved
TerfenadineThe metabolism of Terfenadine can be increased when combined with Rifabutin.Withdrawn
TeriflunomideThe serum concentration of Rifabutin can be decreased when it is combined with Teriflunomide.Approved
TerodilineThe serum concentration of Terodiline can be decreased when it is combined with Rifabutin.Experimental
TesmilifeneThe metabolism of Tesmilifene can be increased when combined with Rifabutin.Investigational
TestosteroneThe metabolism of Testosterone can be increased when combined with Rifabutin.Approved, Investigational
TetracyclineThe metabolism of Tetracycline can be increased when combined with Rifabutin.Approved, Vet Approved
TetrahydropalmatineThe serum concentration of Tetrahydropalmatine can be decreased when it is combined with Rifabutin.Investigational
TheophyllineThe metabolism of Theophylline can be increased when combined with Rifabutin.Approved
ThiamylalThe metabolism of Thiamylal can be increased when combined with Rifabutin.Approved, Vet Approved
ThiopentalThe metabolism of Thiopental can be increased when combined with Rifabutin.Approved, Vet Approved
ThiotepaThe metabolism of Thiotepa can be increased when combined with Rifabutin.Approved
ThymolThe serum concentration of Rifabutin can be increased when it is combined with Thymol.Approved
TiagabineThe metabolism of Tiagabine can be increased when combined with Rifabutin.Approved
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Rifabutin resulting in a loss in efficacy.Approved
TiclopidineThe metabolism of Ticlopidine can be increased when combined with Rifabutin.Approved
TinidazoleThe metabolism of Tinidazole can be increased when combined with Rifabutin.Approved, Investigational
TioclomarolThe metabolism of Tioclomarol can be increased when combined with Rifabutin.Experimental
TioconazoleThe serum concentration of Rifabutin can be increased when it is combined with Tioconazole.Approved
TiotropiumThe metabolism of Tiotropium can be increased when combined with Rifabutin.Approved
TipranavirThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Tipranavir.Approved, Investigational
TixocortolThe serum concentration of Tixocortol can be decreased when it is combined with Rifabutin.Approved
TocilizumabThe serum concentration of Rifabutin can be decreased when it is combined with Tocilizumab.Approved
TofacitinibThe serum concentration of Tofacitinib can be decreased when it is combined with Rifabutin.Approved, Investigational
TolciclateThe serum concentration of Rifabutin can be increased when it is combined with Tolciclate.Experimental
Tolfenamic AcidThe serum concentration of Tolfenamic Acid can be decreased when it is combined with Rifabutin.Approved
TolnaftateThe serum concentration of Rifabutin can be increased when it is combined with Tolnaftate.Approved, Vet Approved
TolterodineThe metabolism of Tolterodine can be increased when combined with Rifabutin.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be decreased when it is combined with Rifabutin.Approved
ToremifeneThe serum concentration of Toremifene can be decreased when it is combined with Rifabutin.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be decreased when it is combined with Rifabutin.Approved, Investigational
TramadolThe metabolism of Tramadol can be increased when combined with Rifabutin.Approved, Investigational
TranilastThe serum concentration of Tranilast can be decreased when it is combined with Rifabutin.Approved, Investigational
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be increased when combined with Rifabutin.Approved
TrazodoneThe metabolism of Trazodone can be increased when combined with Rifabutin.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be increased when combined with Rifabutin.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be increased when combined with Rifabutin.Approved, Vet Approved
TriazolamThe metabolism of Triazolam can be increased when combined with Rifabutin.Approved
TrimethadioneThe metabolism of Trimethadione can be increased when combined with Rifabutin.Approved
TrimethoprimThe metabolism of Trimethoprim can be increased when combined with Rifabutin.Approved, Vet Approved
TrimetrexateThe serum concentration of Rifabutin can be increased when it is combined with Trimetrexate.Approved, Investigational
TrimipramineThe metabolism of Trimipramine can be increased when combined with Rifabutin.Approved
TroglitazoneThe metabolism of Troglitazone can be increased when combined with Rifabutin.Investigational, Withdrawn
TroleandomycinThe metabolism of Troleandomycin can be increased when combined with Rifabutin.Approved
TylosinThe metabolism of Rifabutin can be decreased when combined with Tylosin.Vet Approved
UbidecarenoneThe serum concentration of Ubidecarenone can be decreased when it is combined with Rifabutin.Approved, Experimental
UdenafilThe metabolism of Udenafil can be increased when combined with Rifabutin.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be decreased when it is combined with Rifabutin.Approved
ValbenazineThe metabolism of Valbenazine can be increased when combined with Rifabutin.Approved, Investigational
ValdecoxibThe metabolism of Valdecoxib can be increased when combined with Rifabutin.Investigational, Withdrawn
VandetanibThe serum concentration of Vandetanib can be decreased when it is combined with Rifabutin.Approved
VanoxerineThe metabolism of Vanoxerine can be increased when combined with Rifabutin.Investigational
VardenafilThe metabolism of Vardenafil can be increased when combined with Rifabutin.Approved
VelpatasvirThe metabolism of Velpatasvir can be increased when combined with Rifabutin.Approved
VemurafenibThe serum concentration of Rifabutin can be increased when it is combined with Vemurafenib.Approved
VenetoclaxThe metabolism of Venetoclax can be increased when combined with Rifabutin.Approved
VenlafaxineThe metabolism of Venlafaxine can be increased when combined with Rifabutin.Approved
VerapamilThe metabolism of Verapamil can be increased when combined with Rifabutin.Approved
VicrivirocThe metabolism of Vicriviroc can be increased when combined with Rifabutin.Investigational
VilanterolThe metabolism of Vilanterol can be increased when combined with Rifabutin.Approved
VilazodoneThe serum concentration of Vilazodone can be decreased when it is combined with Rifabutin.Approved
VinblastineThe metabolism of Vinblastine can be increased when combined with Rifabutin.Approved
VincristineThe serum concentration of Vincristine can be decreased when it is combined with Rifabutin.Approved, Investigational
VincristineThe metabolism of Vincristine can be increased when combined with Rifabutin.Approved, Investigational
VindesineThe metabolism of Vindesine can be increased when combined with Rifabutin.Approved, Investigational
VinorelbineThe metabolism of Vinorelbine can be increased when combined with Rifabutin.Approved, Investigational
VinpocetineThe serum concentration of Vinpocetine can be decreased when it is combined with Rifabutin.Investigational
VismodegibThe metabolism of Vismodegib can be increased when combined with Rifabutin.Approved
VorapaxarThe serum concentration of Vorapaxar can be decreased when it is combined with Rifabutin.Approved
VoriconazoleThe serum concentration of Rifabutin can be increased when it is combined with Voriconazole.Approved, Investigational
VortioxetineThe serum concentration of Vortioxetine can be decreased when it is combined with Rifabutin.Approved
VoxilaprevirThe metabolism of Voxilaprevir can be increased when combined with Rifabutin.Approved
WarfarinThe metabolism of Warfarin can be increased when combined with Rifabutin.Approved
XylometazolineThe serum concentration of Xylometazoline can be decreased when it is combined with Rifabutin.Approved
YohimbineThe metabolism of Yohimbine can be increased when combined with Rifabutin.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be increased when combined with Rifabutin.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be increased when combined with Rifabutin.Approved, Investigational
ZaleplonThe serum concentration of Zaleplon can be decreased when it is combined with Rifabutin.Approved, Illicit, Investigational
ZiconotideThe serum concentration of Ziconotide can be decreased when it is combined with Rifabutin.Approved
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Rifabutin.Approved
ZileutonThe metabolism of Zileuton can be increased when combined with Rifabutin.Approved, Investigational, Withdrawn
ZiprasidoneThe metabolism of Ziprasidone can be increased when combined with Rifabutin.Approved
ZolpidemThe serum concentration of Zolpidem can be decreased when it is combined with Rifabutin.Approved
ZomepiracThe metabolism of Zomepirac can be increased when combined with Rifabutin.Withdrawn
ZonisamideThe metabolism of Zonisamide can be increased when combined with Rifabutin.Approved, Investigational
ZopicloneThe metabolism of Zopiclone can be increased when combined with Rifabutin.Approved
ZucapsaicinThe metabolism of Rifabutin can be decreased when combined with Zucapsaicin.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be decreased when it is combined with Rifabutin.Approved, Investigational
Food Interactions
  • High-fat meals slow the rate of absorption.
  • Take with food to reduce irritation.

References

General References
Not Available
External Links
Human Metabolome Database
HMDB14753
KEGG Drug
D00424
KEGG Compound
C07235
PubChem Compound
6323490
PubChem Substance
46506468
ChemSpider
10482168
ChEBI
45367
ChEMBL
CHEMBL444633
Therapeutic Targets Database
DAP000656
PharmGKB
PA451249
HET
RBT
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Rifabutin
ATC Codes
J04AB04 — Rifabutin
AHFS Codes
  • 08:16.04 — Antituberculosis Agents
PDB Entries
2a68 / 4cp3
FDA label
Download (69.5 KB)
MSDS
Download (58.4 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0RecruitingTreatmentOsteomyelitis1
1CompletedNot AvailableHuman Immunodeficiency Virus (HIV) Infections / Infection, Human Immunodeficiency Virus I / Mycobacterium avium complex infection1
1CompletedBasic ScienceHIV / AIDS / Human Immunodeficiency Virus (HIV) Infections1
1CompletedTreatmentAntivirals/HIV1
1CompletedTreatmentHealthy Volunteers3
1CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections2
1CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Infections, Bacterial / Mycoses1
1CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Opioid Dependency1
1CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Tuberculosis1
1CompletedTreatmentTuberculosis1
1RecruitingTreatmentHuman Immunodeficiency Virus (HIV) Infections1
1TerminatedTreatmentHuman Immunodeficiency Virus (HIV) / Tuberculosis1
1Unknown StatusTreatmentChildren With Confirmed HIV Infection / Receiving ART Regimen Containing 2 NRTIs + LPV/RTV at Standard Dose / Successfully Completed TB Treatment in the Past 2 to 6 Weeks of Enrollment1
2CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Infection, Mycobacterium Avium-Intracellulare1
2CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Tuberculosis2
2RecruitingOtherHuman Immunodeficiency Virus (HIV) / Tuberculosis1
2SuspendedTreatmentTuberculosis, Pulmonary1
2TerminatedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Staphylococcus Aureus1
2Unknown StatusTreatmentHuman Immunodeficiency Virus (HIV) / Tuberculosis1
2, 3CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Tuberculosis1
3CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Infection, Mycobacterium Avium-Intracellulare3
3CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Infection, Mycobacterium Avium-Intracellulare / Mycoses1
3RecruitingTreatmentBacterial Infection Due to Helicobacter Pylori (H. Pylori) / Indigestion1
4CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections1
4CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Infection, Mycobacterium Avium-Intracellulare1
4CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Tuberculosis1
4Unknown StatusTreatmentCrohn's Disease (CD)1
4Unknown StatusTreatmentMycobacterium Avium Complex Lung Disease1
4Unknown StatusTreatmentMycobacterium avium complex infection1
4Unknown StatusTreatmentReinfection Pulmonary Tuberculosis1
Not AvailableActive Not RecruitingNot AvailableInhibition of Disseminated Mycobacterium Avium Complex (MAC) Disease Associated With HIV Infections / Inhibition of Disseminated Mycobacterium Avium Complex Disease Associated With HIV Infections / Non-tuberculous Mycobacterial Diseases / Non-tuberculous Mycobacterial Diseases (Including MAC Disease) / Tuberculosis1
Not AvailableCompletedNot AvailableNon-tuberculous Mycobacterial Diseases (Including MAC Disease) / Tuberculosis1
Not AvailableCompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Infection, Mycobacterium Avium-Intracellulare5
Not AvailableCompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Tuberculosis1
Not AvailableRecruitingTreatmentDrug-resistant Tuberculosis / Tuberculosis / Tuberculosis, Multidrug Resistant1
Not AvailableUnknown StatusTreatmentHuman Immunodeficiency Virus (HIV) Infections / Tuberculosis1

Pharmacoeconomics

Manufacturers
  • Pharmacia and upjohn co
Packagers
Dosage forms
FormRouteStrength
CapsuleOral150 mg/1
CapsuleOral150 mg
Prices
Unit descriptionCostUnit
Mycobutin 150 mg capsule13.01USD capsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
water solubilityMinimally soluble (0.19 mg/mL)Not Available
logP4.1Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.017 mg/mLALOGPS
logP4.25ALOGPS
logP4.19ChemAxon
logS-4.7ALOGPS
pKa (Strongest Acidic)7.93ChemAxon
pKa (Strongest Basic)8.62ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count13ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area205.55 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity232.64 m3·mol-1ChemAxon
Polarizability90.72 Å3ChemAxon
Number of Rings6ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.5507
Blood Brain Barrier-0.9921
Caco-2 permeable-0.7072
P-glycoprotein substrateSubstrate0.9612
P-glycoprotein inhibitor IInhibitor0.5415
P-glycoprotein inhibitor IIInhibitor0.6516
Renal organic cation transporterNon-inhibitor0.8178
CYP450 2C9 substrateNon-substrate0.819
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.745
CYP450 1A2 substrateNon-inhibitor0.9046
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorNon-inhibitor0.8308
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8909
Ames testNon AMES toxic0.6724
CarcinogenicityNon-carcinogens0.9195
BiodegradationNot ready biodegradable0.9687
Rat acute toxicity2.5143 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.946
hERG inhibition (predictor II)Inhibitor0.5416
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as macrolactams. These are cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. They are nitrogen analogues (the a nitrogen atom replacing the o atom of the cyclic carboxylic acid group ) of the naturally occurring macrolides.
Kingdom
Organic compounds
Super Class
Phenylpropanoids and polyketides
Class
Macrolactams
Sub Class
Not Available
Direct Parent
Macrolactams
Alternative Parents
Naphthofurans / Azaspirodecane derivatives / Naphthalenes / Benzofurans / Coumarans / Aryl alkyl ketones / Ketals / Piperidines / Vinylogous amides / Vinylogous acids
show 19 more
Substituents
Naphthofuran / Macrolactam / Azaspirodecane / Naphthalene / Benzofuran / Coumaran / Aryl ketone / Aryl alkyl ketone / Ketal / Piperidine
show 40 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
rifamycin (CHEBI:45367)

Targets

Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Yes
Actions
Inhibitor
General Function
Zinc ion binding
Specific Function
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit plays an important role in subunit assembly s...
Gene Name
rpoA
Uniprot ID
P0A7Z4
Uniprot Name
DNA-directed RNA polymerase subunit alpha
Molecular Weight
36511.35 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Maddix DS, Tallian KB, Mead PS: Rifabutin: a review with emphasis on its role in the prevention of disseminated Mycobacterium avium complex infection. Ann Pharmacother. 1994 Nov;28(11):1250-4. [PubMed:7849340]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Yes
Actions
Inhibitor
General Function
Ribonucleoside binding
Specific Function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Gene Name
rpoB
Uniprot ID
P0A8V2
Uniprot Name
DNA-directed RNA polymerase subunit beta
Molecular Weight
150631.165 Da
References
  1. Maddix DS, Tallian KB, Mead PS: Rifabutin: a review with emphasis on its role in the prevention of disseminated Mycobacterium avium complex infection. Ann Pharmacother. 1994 Nov;28(11):1250-4. [PubMed:7849340]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Yes
Actions
Inhibitor
General Function
Dna-directed rna polymerase activity
Specific Function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Gene Name
rpoC
Uniprot ID
P0A8T7
Uniprot Name
DNA-directed RNA polymerase subunit beta'
Molecular Weight
155158.84 Da
References
  1. Maddix DS, Tallian KB, Mead PS: Rifabutin: a review with emphasis on its role in the prevention of disseminated Mycobacterium avium complex infection. Ann Pharmacother. 1994 Nov;28(11):1250-4. [PubMed:7849340]
Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Other/unknown
General Function
Tpr domain binding
Specific Function
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Under...
Gene Name
HSP90AA1
Uniprot ID
P07900
Uniprot Name
Heat shock protein HSP 90-alpha
Molecular Weight
84659.015 Da
References
  1. Schnaider T, Somogyi J, Csermely P, Szamel M: The Hsp90-specific inhibitor geldanamycin selectively disrupts kinase-mediated signaling events of T-lymphocyte activation. Cell Stress Chaperones. 2000 Jan;5(1):52-61. [PubMed:10701840]
  2. Neckers L, Schulte TW, Mimnaugh E: Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity. Invest New Drugs. 1999;17(4):361-73. [PubMed:10759403]
  3. Srethapakdi M, Liu F, Tavorath R, Rosen N: Inhibition of Hsp90 function by ansamycins causes retinoblastoma gene product-dependent G1 arrest. Cancer Res. 2000 Jul 15;60(14):3940-6. [PubMed:10919672]
  4. Munster PN, Srethapakdi M, Moasser MM, Rosen N: Inhibition of heat shock protein 90 function by ansamycins causes the morphological and functional differentiation of breast cancer cells. Cancer Res. 2001 Apr 1;61(7):2945-52. [PubMed:11306472]
  5. Yang J, Yang JM, Iannone M, Shih WJ, Lin Y, Hait WN: Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to inhibit glioblastoma by geldanamycin. Cancer Res. 2001 May 15;61(10):4010-6. [PubMed:11358819]
Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Other/unknown
General Function
Virion binding
Specific Function
Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in...
Gene Name
HSP90B1
Uniprot ID
P14625
Uniprot Name
Endoplasmin
Molecular Weight
92468.06 Da
References
  1. Barzilay E, Ben-Califa N, Supino-Rosin L, Kashman Y, Hirschberg K, Elazar Z, Neumann D: Geldanamycin-associated inhibition of intracellular trafficking is attributed to a co-purified activity. J Biol Chem. 2004 Feb 20;279(8):6847-52. Epub 2003 Dec 1. [PubMed:14660597]
  2. Chavany C, Mimnaugh E, Miller P, Bitton R, Nguyen P, Trepel J, Whitesell L, Schnur R, Moyer J, Neckers L: p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2. J Biol Chem. 1996 Mar 1;271(9):4974-7. [PubMed:8617772]
  3. Lawson B, Brewer JW, Hendershot LM: Geldanamycin, an hsp90/GRP94-binding drug, induces increased transcription of endoplasmic reticulum (ER) chaperones via the ER stress pathway. J Cell Physiol. 1998 Feb;174(2):170-8. [PubMed:9428803]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inducer
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  2. Ekins S, Bravi G, Wikel JH, Wrighton SA: Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates. J Pharmacol Exp Ther. 1999 Oct;291(1):424-33. [PubMed:10490933]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A2
Uniprot ID
P05177
Uniprot Name
Cytochrome P450 1A2
Molecular Weight
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]

Drug created on June 13, 2005 07:24 / Updated on November 14, 2017 08:04