Peptidyl-prolyl cis-trans isomerase A

Details

Name
Peptidyl-prolyl cis-trans isomerase A
Synonyms
  • 5.2.1.8
  • Cyclophilin A
  • Cyclosporin A-binding protein
  • CYPA
  • PPIase A
  • Rotamase A
Gene Name
PPIA
Organism
Humans
Amino acid sequence
>lcl|BSEQ0002019|Peptidyl-prolyl cis-trans isomerase A
MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGF
MCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTE
WLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE
Number of residues
165
Molecular Weight
18012.42
Theoretical pI
7.97
GO Classification
Functions
peptide binding / peptidyl-prolyl cis-trans isomerase activity / poly(A) RNA binding / unfolded protein binding / virion binding
Processes
blood coagulation / entry into host cell / establishment of integrated proviral latency / leukocyte migration / lipid particle organization / platelet activation / platelet degranulation / positive regulation of protein secretion / positive regulation of viral genome replication / protein folding / protein peptidyl-prolyl isomerization / regulation of viral genome replication / RNA-dependent DNA replication / uncoating of virus / viral life cycle / viral process / viral release from host cell / virion assembly
Components
cytosol / extracellular exosome / extracellular region / extracellular space / focal adhesion / membrane / nucleus
General Function
Virion binding
Specific Function
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0010711|Peptidyl-prolyl cis-trans isomerase A (PPIA)
ATGTGTCAGGGTGGTGACTTCACACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGG
GAGAAATTTGAAGATGAGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTTGTCCATG
GCAAATGCTGGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCACTGCCAAGACTGAG
TGGTTGGATGGCAAGCATGTGGTGTTTGGCAAAGTGAAAGAAGGCATGAATATTGTGGAG
GCCATGGAGCGCTTTGGGTCCAGGAATGGCAAGACCAGCAAGAAGATCACCATTGCTGAC
TGTGGACAACTCGAATAA
Chromosome Location
7
Locus
7p13
External Identifiers
ResourceLink
UniProtKB IDP62937
UniProtKB Entry NamePPIA_HUMAN
GenBank Protein ID30309
GenBank Gene IDY00052
GenAtlas IDPPIA
HGNC IDHGNC:9253
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00091Cyclosporineapproved, investigational, vet_approvedyesinhibitorbinderDetails
DB01742(3r)-1-Acetyl-3-MethylpiperidineexperimentalunknownDetails
DB03393Sanglifehrin AexperimentalunknownDetails
DB00172ProlinenutraceuticalunknownbinderDetails
DB02419Ethyl Oxo(Piperidin-1-Yl)AcetateexperimentalunknownDetails
DB09130Copperapproved, investigationalunknownDetails
DB11638Artenimolexperimental, investigationalunknownligandDetails