Beclin-1

Details

Name
Beclin-1
Synonyms
  • Coiled-coil myosin-like BCL2-interacting protein
  • GT197
  • Protein GT197
Gene Name
BECN1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0049743|Beclin-1
MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE
ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG
DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL
QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ
LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW
NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFF
WDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFN
SEEQWTKALKFMLTNLKWGLAWVSSQFYNK
Number of residues
450
Molecular Weight
51895.945
Theoretical pI
Not Available
GO Classification
Functions
phosphatidylinositol 3-kinase binding / ubiquitin protein ligase binding
Processes
aging / apoptotic process / autophagosome assembly / autophagy / beta-amyloid metabolic process / cellular defense response / cellular response to aluminum ion / cellular response to amino acid starvation / cellular response to copper ion / cellular response to epidermal growth factor stimulus / cellular response to glucose starvation / cellular response to hydrogen peroxide / cellular response to nitrogen starvation / cytokinesis / defense response to virus / engulfment of apoptotic cell / late endosome to vacuole transport / lysosome organization / macroautophagy / macromitophagy / mitophagy / mitotic metaphase plate congression / negative regulation of apoptotic process / negative regulation of cell death / negative regulation of cell proliferation / negative regulation of lysosome organization / negative regulation of reactive oxygen species metabolic process / neuron development / nucleophagy / positive regulation of attachment of mitotic spindle microtubules to kinetochore / positive regulation of autophagosome assembly / positive regulation of phosphatidylinositol 3-kinase signaling / protein deubiquitination / receptor catabolic process / regulation of catalytic activity / regulation of cytokinesis / response to drug / response to hypoxia / response to iron(II) ion / response to lead ion / response to mitochondrial depolarisation / response to vitamin E
Components
autophagosome / cytosol / dendrite / endoplasmic reticulum / endoplasmic reticulum membrane / endosome / endosome membrane / extrinsic component of membrane / mitochondrial membrane / nucleus / phagocytic vesicle / phosphatidylinositol 3-kinase complex, class III / phosphatidylinositol 3-kinase complex, class III, type I / phosphatidylinositol 3-kinase complex, class III, type II / pre-autophagosomal structure / protein complex / trans-Golgi network
General Function
Plays a central role in autophagy (PubMed:23184933). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense.
Specific Function
Phosphatidylinositol 3-kinase binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0049744|Beclin-1 (BECN1)
ATGGAAGGGTCTAAGACGTCCAACAACAGCACCATGCAGGTGAGCTTCGTGTGCCAGCGC
TGCAGCCAGCCCCTGAAACTGGACACGAGTTTCAAGATCCTGGACCGTGTCACCATCCAG
GAACTCACAGCTCCATTACTTACCACAGCCCAGGCGAAACCAGGAGAGACCCAGGAGGAA
GAGACTAACTCAGGAGAGGAGCCATTTATTGAAACTCCTCGCCAGGATGGTGTCTCTCGC
AGATTCATCCCCCCAGCCAGGATGATGTCCACAGAAAGTGCCAACAGCTTCACTCTGATT
GGGGAGGCATCTGATGGCGGCACCATGGAGAACCTCAGCCGAAGACTGAAGGTCACTGGG
GACCTTTTTGACATCATGTCGGGCCAGACAGATGTGGATCACCCACTCTGTGAGGAATGC
ACAGATACTCTTTTAGACCAGCTGGACACTCAGCTCAACGTCACTGAAAATGAGTGTCAG
AACTACAAACGCTGTTTGGAGATCTTAGAGCAAATGAATGAGGATGACAGTGAACAGTTA
CAGATGGAGCTAAAGGAGCTGGCACTAGAGGAGGAGAGGCTGATCCAGGAGCTGGAAGAC
GTGGAAAAGAACCGCAAGATAGTGGCAGAAAATCTCGAGAAGGTCCAGGCTGAGGCTGAG
AGACTGGATCAGGAGGAAGCTCAGTATCAGAGAGAATACAGTGAATTTAAACGACAGCAG
CTGGAGCTGGATGATGAGCTGAAGAGTGTTGAAAACCAGATGCGTTATGCCCAGACGCAG
CTGGATAAGCTGAAGAAAACCAACGTCTTTAATGCAACCTTCCACATCTGGCACAGTGGA
CAGTTTGGCACAATCAATAACTTCAGGCTGGGTCGCCTGCCCAGTGTTCCCGTGGAATGG
AATGAGATTAATGCTGCTTGGGGCCAGACTGTGTTGCTGCTCCATGCTCTGGCCAATAAG
ATGGGTCTGAAATTTCAGAGATACCGACTTGTTCCTTACGGAAACCATTCATATCTGGAG
TCTCTGACAGACAAATCTAAGGAGCTGCCGTTATACTGTTCTGGGGGGTTGCGGTTTTTC
TGGGACAACAAGTTTGACCATGCAATGGTGGCTTTCCTGGACTGTGTGCAGCAGTTCAAA
GAAGAGGTTGAGAAAGGCGAGACACGTTTTTGTCTTCCCTACAGGATGGATGTGGAGAAA
GGCAAGATTGAAGACACAGGAGGCAGTGGCGGCTCCTATTCCATCAAAACCCAGTTTAAC
TCTGAGGAGCAGTGGACAAAAGCTCTCAAGTTCATGCTGACGAATCTTAAGTGGGGTCTT
GCTTGGGTGTCCTCACAATTTTATAACAAATGA
Chromosome Location
17
Locus
17q21.31
External Identifiers
ResourceLink
UniProtKB IDQ14457
UniProtKB Entry NameBECN1_HUMAN
HGNC IDHGNC:1034
General References
  1. Liang XH, Kleeman LK, Jiang HH, Gordon G, Goldman JE, Berry G, Herman B, Levine B: Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol. 1998 Nov;72(11):8586-96. [PubMed:9765397]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00783Estradiolapproved, investigational, vet_approvedunknownDetails
DB13952Estradiol acetateapproved, investigational, vet_approvedunknownDetails
DB13953Estradiol benzoateapproved, investigational, vet_approvedunknownDetails
DB13954Estradiol cypionateapproved, investigational, vet_approvedunknownDetails
DB13955Estradiol dienanthateapproved, investigational, vet_approvedunknownDetails
DB13956Estradiol valerateapproved, investigational, vet_approvedunknownDetails