Unlocking Undruggable Targets: Shifting Paradigms in Modern Drug Discovery
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Substrate
Enzyme
Products
Clear
Tegafur-uracil
DB09327
Cytochrome P450 2A6
3-hydroxytegafur
/
4-hydroxytegafur
/
5-hydroxytegafur
/
dihydrotegafur
Details
Tegaserod
DB01079
Not Available
5-methoxyindole-3-carboxylic acid
Details
Telaprevir
DB05521
Not Available
Pyrazinoic acid
Details
Telavancin
DB06402
Not Available
THRX-651540
Details
Telotristat
DBMET03552
Not Available
M1 telotristat
Details
Telotristat ethyl
DB12095
Liver carboxylesterase 1
/
Cocaine esterase
Telotristat
Details
Temazepam
DB00231
Not Available
Oxazepam glucuronide
Details
Temazepam
DB00231
Cytochrome P450 2B6
/
Cytochrome P450 2C9
/
Cytochrome P450 2C19
/
Cytochrome P450 3A4
/
Cytochrome P450 3A5
Oxazepam
Details
Temazepam
DB00231
Cytochrome P450 3A4
/
Cytochrome P450 2C19
Oxazepam
Details
Temozolomide
DB00853
Not Available
Temozolomide carboxylic acid metabolite (TMA)
Details
Temozolomide
DB00853
Not Available
5-(3-methyltriazen-1-yl) imidazole-4-carboxamide (MTIC)
Details
Temsavir
DBMET03183
Cytochrome P450 3A4
BMS-930644 (N-dealkylated metabolite)
Details
Temsavir
DBMET03183
Not Available
BMS-646915 (hydrolysis metabolite)
Details
Temsirolimus
DB06287
Not Available
Sirolimus
Details
Tenapanor
DB11761
Cytochrome P450 3A4
/
Cytochrome P450 3A5
Tenapanor M1 metabolite
Details
Teniposide
DB00444
Cytochrome P450 3A5
/
Cytochrome P450 3A4
Teniposide catechol derivative
Details
Teniposide
DB00444
Cytochrome P450 3A4
/
Cytochrome P450 3A5
Teniposide catechol
Details
Teniposide catechol derivative
DBMET01262
Myeloperoxidase
Teniposide o-quinone derivative
Details
Tenofovir
DB14126
Adenylate kinase isoenzyme 1
/
Adenylate kinase 2, mitochondrial
Tenofovir Monophosphate
Details
Tenofovir
DBMET01425
Adenylate kinase isoenzyme 1
/
Adenylate kinase 2, mitochondrial
Tenofovir Monophosphate
Details
Tenofovir alafenamide
DB09299
Lysosomal protective protein
/
Liver carboxylesterase 1
Tenofovir alanine
Details
Tenofovir alanine
DBMET03569
Histidine triad nucleotide-binding protein 1
Tenofovir
Details
Tenofovir disoproxil
DB00300
Adenylate kinase 2, mitochondrial
/
Adenylate kinase 4, mitochondrial
Tenofovir Monophosphate
Details
Tenofovir Monophosphate
DBMET01176
Nucleoside diphosphate kinase A
/
Nucleoside diphosphate kinase B
Tenofovir Diphosphate
Details
Tenofovir Monophosphate
DBMET01176
Nucleoside diphosphokinase
/
Creatine Kinases
Tenofovir Diphosphate
Details
Tenofovir Monophosphate
DBMET01176
Nucleoside diphosphate kinase A
/
Nucleoside diphosphate kinase B
Tenofovir Diphosphate
Details
Tenoxicam
DB00469
Cytochrome P450 2C9
5'-Hydroxytenoxicam
Details
Tepotinib
DB15133
Cytochrome P450 3A4
/
Cytochrome P450 2C8
Tepotinib M506 metabolite
Details
Tepotinib
DB15133
Not Available
Tepotinib M478 metabolite
Details
Tepotinib
DB15133
Not Available
Tepotinib M508 metabolite
Details
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