Identification

Name
Temozolomide
Accession Number
DB00853  (APRD00557)
Type
Small Molecule
Groups
Approved, Investigational
Description

Temozolomide (Temodar and Temodal) is an oral alkylating agent used for the treatment of refractory anaplastic astrocytoma -- a type of cancerous brain tumor. Temozolomide is not active until it is converted at physiologic pH to the active form, 5-(3-methyltriazen-1-yl)imidazole-4-carboxamide (MTIC).

Structure
Thumb
Synonyms
  • 3-methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide
  • 3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide
  • 3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide
  • 8-carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one
  • Methazolastone
  • Temozolodida
  • Temozolomid
  • Temozolomida
  • Temozolomide
  • Témozolomide
  • Temozolomidum
External IDs
BRN 5547136 / CCRG 81045 / CCRG-81045 / M & B 39831 / M&B 39831 / M&B-39831 / MK-7365 / NSC 362856 / NSC-362856 / SCH 52365 / SCH-52365
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Act TemozolomideCapsule100 mgOralActavis Pharma Company2012-11-07Not applicableCanada
Act TemozolomideCapsule5 mgOralActavis Pharma Company2015-12-08Not applicableCanada
Act TemozolomideCapsule250 mgOralActavis Pharma Company2012-11-07Not applicableCanada
Act TemozolomideCapsule180 mgOralActavis Pharma CompanyNot applicableNot applicableCanada
Act TemozolomideCapsule140 mgOralActavis Pharma Company2012-11-07Not applicableCanada
Act TemozolomideCapsule20 mgOralActavis Pharma Company2012-11-07Not applicableCanada
TemodalCapsule140 mgOralMerck Sharp & Dohme Limited1999-01-26Not applicableEu
TemodalCapsule20 mgOralMerck Sharp & Dohme Limited1999-01-26Not applicableEu
TemodalCapsule100 mgOralMerck Sharp & Dohme Limited1999-01-26Not applicableEu
TemodalCapsule5 mgOralMerck Ltd.1999-11-12Not applicableCanada
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ach-temozolomideCapsule20 mgOralAccord Healthcare Limited2012-07-25Not applicableCanada
Ach-temozolomideCapsule140 mgOralAccord Healthcare Limited2012-07-25Not applicableCanada
Ach-temozolomideCapsule250 mgOralAccord Healthcare Limited2012-07-25Not applicableCanada
Ach-temozolomideCapsule100 mgOralAccord Healthcare Limited2012-07-25Not applicableCanada
Ach-temozolomideCapsule180 mgOralAccord Healthcare Limited2012-07-25Not applicableCanada
Ach-temozolomideCapsule5 mgOralAccord Healthcare Limited2016-01-13Not applicableCanada
Apo-temozolomideCapsule20 mgOralApotex CorporationNot applicableNot applicableCanada
Apo-temozolomideCapsule140 mgOralApotex CorporationNot applicableNot applicableCanada
Apo-temozolomideCapsule250 mgOralApotex CorporationNot applicableNot applicableCanada
Apo-temozolomideCapsule100 mgOralApotex CorporationNot applicableNot applicableCanada
International/Other Brands
Temodar
Categories
UNII
YF1K15M17Y
CAS number
85622-93-1
Weight
Average: 194.1508
Monoisotopic: 194.055223466
Chemical Formula
C6H6N6O2
InChI Key
BPEGJWRSRHCHSN-UHFFFAOYSA-N
InChI
InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)
IUPAC Name
3-methyl-4-oxo-3H,4H-imidazo[4,3-d][1,2,3,5]tetrazine-8-carboxamide
SMILES
CN1N=NC2=C(N=CN2C1=O)C(N)=O

Pharmacology

Indication

For the treatment of adult patients diagnosed with anaplastic astrocytoma whose disease has progressed after therapy with nitrosourea and procarbazine, as well as concomitantly with radiation therapy for treatment of newly diagnosed glioblastoma multiforme. Also used as maintenance therapy for glioblastoma multiforme.

Associated Conditions
Pharmacodynamics

Temozolomide is an imidazotetrazine deritave and an antineoplastic agent. It is a prodrug that has little to no pharmacological activity until it is hydrolyzed in vivo to 5-(3-methyltriazen-1-yl)imidazole-4-carboxamide (MTIC). After administration, temozolomide undergoes rapid, nonenzymatic hydrolysis at physiological pH to MTIC, which is the active form of the drug. MTIC is generated through the effect of water at the highly electropositive C4 position of temozolomide, causing the ring of temozolomide to open, release carbon dioxide, and generate MTIC.

Mechanism of action

Temozolomide is not active until it is converted at physiologic pH to MTIC. It is suggested that MTIC then alkylates DNA at the N7 position of guanine, O3 position of adenosine, and O6 position of guanosine, with the most common site being the N7 position. This methylation of guanine residues lead to single and double-strand DNA breaks and subsequent apoptotic cell death. It is suggested that the N7-methylguanine plays a critical role in the antitumor activity of the drug, as there is a correlation between the sensitivity of tumor cell lines to temozolomide and the activity of O6-alkylguanine alkyltransferase, which is the DNA repair protein that specifically removes alkyl groups at the O6 position of guanine. Cells lines that have lower levels of AGT are more sensitive to the cytotoxicity of temozolomide. It is also suggested that cytotoxic mechanism of temozolomide is related to the failure of the DNA MMR system to find a complementary base for methylated guanine. The DNA MMR system is involved in the formation of a number of proteins that remove methylated guanine. Evidence shows that when this repair process is targeted to the DNA strand opposite the O6-methylguanine, its inability to find the correct target leads to long-lived nicks in the DNA. The accumulation of these nicks lead to the inhibition of replication in the daughter cells, thereby blocking the cell cycle at the G2-M boundary.

TargetActionsOrganism
ADNA
cross-linking/alkylation
Human
Absorption

Rapid and complete absorption in the gastrointestinal tract

Volume of distribution
  • 0.4 L/kg
Protein binding

15%

Metabolism
Not Available
Route of elimination

About 38% of the administered temozolomide total radioactive dose is recovered over 7 days: 37.7% in urine and 0.8% in feces.

Half life

Approximately 1.8 hours.

Clearance
  • 5.5 L/hr/m2
Toxicity
Not Available
Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
(R)-warfarinThe metabolism of (R)-warfarin can be increased when combined with Temozolomide.
(S)-WarfarinThe metabolism of (S)-Warfarin can be increased when combined with Temozolomide.
2-MethoxyethanolThe risk or severity of adverse effects can be increased when Temozolomide is combined with 2-Methoxyethanol.
3,5-diiodothyropropionic acidThe metabolism of 3,5-diiodothyropropionic acid can be increased when combined with Temozolomide.
4-hydroxycoumarinThe metabolism of 4-hydroxycoumarin can be increased when combined with Temozolomide.
5-androstenedioneThe metabolism of 5-androstenedione can be increased when combined with Temozolomide.
6-O-benzylguanineThe metabolism of 6-O-benzylguanine can be increased when combined with Temozolomide.
7-ethyl-10-hydroxycamptothecinThe metabolism of 7-ethyl-10-hydroxycamptothecin can be increased when combined with Temozolomide.
9-(N-methyl-L-isoleucine)-cyclosporin AThe risk or severity of adverse effects can be increased when Temozolomide is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
9-aminocamptothecinThe metabolism of 9-aminocamptothecin can be increased when combined with Temozolomide.
Food Interactions
Not Available

References

Synthesis Reference

Shen-Chun Kuo, "Synthesis of temozolomide and analogs." U.S. Patent US20020133006, issued September 19, 2002.

US20020133006
General References
  1. Neyns B, Tosoni A, Hwu WJ, Reardon DA: Dose-dense temozolomide regimens: antitumor activity, toxicity, and immunomodulatory effects. Cancer. 2010 Jun 15;116(12):2868-77. doi: 10.1002/cncr.25035. [PubMed:20564393]
  2. Wick W, Platten M, Weller M: New (alternative) temozolomide regimens for the treatment of glioma. Neuro Oncol. 2009 Feb;11(1):69-79. doi: 10.1215/15228517-2008-078. Epub 2008 Sep 4. [PubMed:18772354]
  3. Villano JL, Seery TE, Bressler LR: Temozolomide in malignant gliomas: current use and future targets. Cancer Chemother Pharmacol. 2009 Sep;64(4):647-55. doi: 10.1007/s00280-009-1050-5. Epub 2009 Jun 19. [PubMed:19543728]
  4. Meije Y, Lizasoain M, Garcia-Reyne A, Martinez P, Rodriguez V, Lopez-Medrano F, Juan RS, Lalueza A, Aguado JM: Emergence of cytomegalovirus disease in patients receiving temozolomide: report of two cases and literature review. Clin Infect Dis. 2010 Jun 15;50(12):e73-6. doi: 10.1086/653011. [PubMed:20455691]
  5. Trinh VA, Patel SP, Hwu WJ: The safety of temozolomide in the treatment of malignancies. Expert Opin Drug Saf. 2009 Jul;8(4):493-9. doi: 10.1517/14740330902918281 . [PubMed:19435405]
  6. Yung WK: Temozolomide in malignant gliomas. Semin Oncol. 2000 Jun;27(3 Suppl 6):27-34. [PubMed:10866347]
  7. Friedman HS, Kerby T, Calvert H: Temozolomide and treatment of malignant glioma. Clin Cancer Res. 2000 Jul;6(7):2585-97. [PubMed:10914698]
  8. Mutter N, Stupp R: Temozolomide: a milestone in neuro-oncology and beyond? Expert Rev Anticancer Ther. 2006 Aug;6(8):1187-204. [PubMed:16925485]
External Links
Human Metabolome Database
HMDB0014991
KEGG Drug
D06067
PubChem Compound
5394
PubChem Substance
46507934
ChemSpider
5201
BindingDB
50034562
ChEBI
72564
ChEMBL
CHEMBL810
Therapeutic Targets Database
DAP000987
PharmGKB
PA451609
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Temozolomide
ATC Codes
L01AX03 — Temozolomide
AHFS Codes
  • 10:00.00 — Antineoplastic Agents
FDA label
Download (67.2 KB)
MSDS
Download (58 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0Active Not RecruitingTreatmentAdult Giant Cell Glioblastoma / Adult Glioblastoma / Adult Gliosarcoma / Giant Cell Glioblastoma / Glioblastomas / Gliosarcoma1
0Active Not RecruitingTreatmentDesmoplastic Small Round Cell Tumor (DSRCT) / Sarcomas1
0CompletedDiagnosticBlood Brain Barrier Defect1
0CompletedTreatmentDiffuse Intrinsic Pontine Glioma (DIPG) / Newly Diagnosed High-Grade Gliomas1
0CompletedTreatmentGlioblastomas1
0Not Yet RecruitingTreatmentChildhood CNS Tumor1
0RecruitingOtherGlioblastoma Multiforme (GBM)1
0RecruitingTreatmentGlioblastomas1
0RecruitingTreatmentGrade II/III Glioma1
0RecruitingTreatmentHigh Grade Glioma (HGG)1
0RecruitingTreatmentNeuroblastoma (NB)1
0WithdrawnTreatmentAstrocytomas / Brain Stem Gliomas / Ependymomas / Mixed Gliomas / Oligodendrogliomas / Optic Nerve Glioma1
1Active Not RecruitingTreatmentAccelerated Phase of Disease / Acute Lymphoblastic Leukaemias (ALL) / Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome / Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11 / Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11 / Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); RUNX1-RUNX1T1 / Adult Acute Myeloid Leukemia With t(8;21); (q22; q22.1); RUNX1-RUNX1T1 / Adult Acute Myeloid Leukemia With t(9;11)(p22.3;q23.3); MLLT3-KMT2A / Adult Acute Myeloid Leukemia With t(9;11)(p22;q23); MLLT3-MLL / Adult Acute Promyelocytic Leukemia With PML-RARA / Adult Acute Promyelocytic Leukemia With t(15;17)(q22;q12); PML-RARA / Adult B Acute Lymphoblastic Leukemia / Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 / Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 / Adult T Acute Lymphoblastic Leukemia / Alkylating Agent-Related Acute Myeloid Leukemia / Blastic Phase / Chronic Myelomonocytic Leukemia / Leukemia Acute Myeloid Leukemia (AML) / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Recurrent Disease / Secondary Acute Myeloid Leukemia (Secondary AML, sAML) / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Adult Acute Myeloid Leukemia1
1Active Not RecruitingTreatmentAdult Anaplastic Astrocytoma / Adult Anaplastic Oligodendroglioma / Adult Giant Cell Glioblastoma / Adult Glioblastoma / Adult Gliosarcoma / Adult Mixed Glioma / Recurrent Adult Brain Neoplasm1
1Active Not RecruitingTreatmentAnaplastic Astrocytoma (AA) / Glioblastoma Multiforme (GBM)1
1Active Not RecruitingTreatmentBrain Cancer1
1Active Not RecruitingTreatmentBrain Cancer / Brain Neoplasms, Recurrent / Cancer of the Brain / Neoplasms, Brain / Primary Brain Neoplasms1
1Active Not RecruitingTreatmentBrain and Central Nervous System Tumors1
1Active Not RecruitingTreatmentCancer, Advanced / Tumors, Solid1
1Active Not RecruitingTreatmentEwing's Sarcoma (ES)1
1Active Not RecruitingTreatmentGBM / Giant Cell Glioblastoma / Glioblastoma Multiforme (GBM) / Glioblastoma With Oligodendroglial Features / Glioblastomas / Gliosarcoma / MGMT-methylated Glioblastoma / MGMT-unmethylated Glioblastoma1
1Active Not RecruitingTreatmentGBM / Glioblastoma Multiforme (GBM) / Glioblastomas1
1Active Not RecruitingTreatmentGlioblastoma Multiforme (GBM) / Gliosarcoma / Malignant Supratentorial Neoplasm / Neoplasms, Brain / Recurrent Glioblastoma / Recurrent Gliosarcoma1
1Active Not RecruitingTreatmentGlioblastomas3
1Active Not RecruitingTreatmentGlioblastomas / Gliosarcoma / Supratentorial Glioblastoma1
1Active Not RecruitingTreatmentGlioma, Malignant1
1Active Not RecruitingTreatmentMalignant Gliomas1
1Active Not RecruitingTreatmentMetastatic Cancers / Unspecified Adult Solid Tumor1
1Active Not RecruitingTreatmentNewly Diagnosed High Grade Glioma1
1Active Not RecruitingTreatmentRectal Carcinoma1
1Active Not RecruitingTreatmentSolid Tumors, Glioblastoma, Recurrent Malignant Gliomas1
1CompletedTreatmentAcoustic Schwannoma / Adult Anaplastic (Malignant) Meningioma / Adult Anaplastic Astrocytoma / Adult Anaplastic Ependymoma / Adult Brain Stem Glioma / Adult Choroid Plexus Neoplasm / Adult Craniopharyngioma / Adult Diffuse Astrocytoma / Adult Ependymoblastoma / Adult Ependymoma / Adult Giant Cell Glioblastoma / Adult Glioblastoma / Adult Gliosarcoma / Adult Grade I Meningioma / Adult Grade II Meningioma / Adult Medulloblastoma / Adult Mixed Glioma / Adult Myxopapillary Ependymoma / Adult Oligodendroglioma / Adult Papillary Meningioma / Adult Pilocytic Astrocytoma / Adult Pineal Gland Astrocytoma / Adult Pineoblastoma / Adult Pineocytoma / Adult Primary Melanocytic Lesion of Meninges / Adult Subependymal Giant Cell Astrocytoma / Adult Subependymoma / Adult Supratentorial Primitive Neuroectodermal Tumor / Malignant Adult Intracranial Hemangiopericytoma1
1CompletedTreatmentAdult Anaplastic Astrocytoma / Adult Anaplastic Oligodendroglioma / Adult Giant Cell Glioblastoma / Adult Glioblastoma / Adult Gliosarcoma / Adult Mixed Glioma / Recurrent Adult Brain Tumor1
1CompletedTreatmentAdult Brain Glioblastoma / Adult Giant Cell Glioblastoma / Adult Gliosarcoma1
1CompletedTreatmentAdult Giant Cell Glioblastoma / Adult Glioblastoma / Adult Gliosarcoma3
1CompletedTreatmentAnaplastic Astrocytoma (AA) / Glioblastomas / Gliosarcoma2
1CompletedTreatmentAstrocytomas / Ependymomas / Medulloblastomas / PNET / Pontine Glioma1
1CompletedTreatmentBrain and Central Nervous System Tumors14
1CompletedTreatmentBrain and Central Nervous System Tumors / Cancer of the Ovary / Childhood Germ Cell Tumor / Extragonadal Germ Cell Tumor / Liver Cancer / Neuroblastomas / Renal Cancers / Sarcomas / Unspecified Childhood Solid Tumor, Protocol Specific1
1CompletedTreatmentBrain and Central Nervous System Tumors / Cancer of the Ovary / Childhood Germ Cell Tumor / Liver Cancer / Neuroblastomas / Renal Cancers / Sarcomas / Unspecified Childhood Solid Tumor, Protocol Specific1
1CompletedTreatmentBrain and Central Nervous System Tumors / Malignant Lymphomas / Metastatic Cancers / Unspecified Adult Solid Tumor, Protocol Specific1
1CompletedTreatmentBrain and Central Nervous System Tumors / Metastatic Cancers1
1CompletedTreatmentBrain and Central Nervous System Tumors / Unspecified Childhood Solid Tumor, Protocol Specific1
1CompletedTreatmentCancer of the Ovary / Cancer, Breast / Fallopian Tube Cancer / Hepatocellular,Carcinoma / Metastatic Melanoma / Non-hematologic Malignancies / Primary Peritoneal Cancer1
1CompletedTreatmentChildhood Atypical Teratoid/Rhabdoid Tumor / Childhood Central Nervous System Choriocarcinoma / Childhood Central Nervous System Embryonal Tumor / Childhood Central Nervous System Germinoma / Childhood Central Nervous System Mixed Germ Cell Tumor / Childhood Central Nervous System Teratoma / Childhood Central Nervous System Yolk Sac Tumor / Childhood Choroid Plexus Tumor / Childhood Craniopharyngioma / Childhood Ependymoblastoma / Childhood Grade I Meningioma / Childhood Grade II Meningioma / Childhood Grade III Meningioma / Childhood High-grade Cerebellar Astrocytoma / Childhood High-grade Cerebral Astrocytoma / Childhood Infratentorial Ependymoma / Childhood Low-grade Cerebellar Astrocytoma / Childhood Low-grade Cerebral Astrocytoma / Childhood Medulloepithelioma / Childhood Mixed Glioma / Childhood Oligodendroglioma / Childhood Supratentorial Ependymoma / Extra-Adrenal Paraganglioma / Recurrent Childhood Brain Stem Glioma / Recurrent Childhood Central Nervous System Embryonal Tumor / Recurrent Childhood Cerebellar Astrocytoma / Recurrent Childhood Cerebral Astrocytoma / Recurrent Childhood Ependymoma / Recurrent Childhood Medulloblastoma / Recurrent Childhood Pineoblastoma / Recurrent Childhood Spinal Cord Neoplasm / Recurrent Childhood Subependymal Giant Cell Astrocytoma / Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor / Recurrent Childhood Visual Pathway and Hypothalamic Glioma1
1CompletedTreatmentChildhood Atypical Teratoid/Rhabdoid Tumor / Childhood Central Nervous System Germ Cell Tumor / Childhood Choroid Plexus Tumor / Childhood Craniopharyngioma / Childhood Ependymoblastoma / Childhood Grade I Meningioma / Childhood Grade II Meningioma / Childhood Grade III Meningioma / Childhood High-grade Cerebellar Astrocytoma / Childhood High-grade Cerebral Astrocytoma / Childhood Infratentorial Ependymoma / Childhood Low-grade Cerebellar Astrocytoma / Childhood Low-grade Cerebral Astrocytoma / Childhood Medulloepithelioma / Childhood Mixed Glioma / Childhood Oligodendroglioma / Childhood Supratentorial Ependymoma / Recurrent Childhood Brain Stem Glioma / Recurrent Childhood Brain Tumor / Recurrent Childhood Cerebellar Astrocytoma / Recurrent Childhood Cerebral Astrocytoma / Recurrent Childhood Ependymoma / Recurrent Childhood Medulloblastoma / Recurrent Childhood Pineoblastoma / Recurrent Childhood Spinal Cord Neoplasm / Recurrent Childhood Subependymal Giant Cell Astrocytoma / Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor / Recurrent Childhood Visual Pathway and Hypothalamic Glioma1
1CompletedTreatmentChildhood Central Nervous System Germ Cell Tumor / Childhood Choroid Plexus Tumor / Childhood Craniopharyngioma / Childhood Ependymoblastoma / Childhood Grade I Meningioma / Childhood Grade II Meningioma / Childhood Grade III Meningioma / Childhood High-grade Cerebellar Astrocytoma / Childhood High-grade Cerebral Astrocytoma / Childhood Infratentorial Ependymoma / Childhood Low-grade Cerebellar Astrocytoma / Childhood Low-grade Cerebral Astrocytoma / Childhood Medulloepithelioma / Childhood Mixed Glioma / Childhood Oligodendroglioma / Childhood Supratentorial Ependymoma / Recurrent Childhood Brain Stem Glioma / Recurrent Childhood Cerebellar Astrocytoma / Recurrent Childhood Cerebral Astrocytoma / Recurrent Childhood Ependymoma / Recurrent Childhood Medulloblastoma / Recurrent Childhood Pineoblastoma / Recurrent Childhood Subependymal Giant Cell Astrocytoma / Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor / Recurrent Childhood Visual Pathway and Hypothalamic Glioma1
1CompletedTreatmentChronic Lung Diseases / Malignancies1
1CompletedTreatmentDrug/Agent Toxicity by Tissue/Organ / Neuroblastomas / Severe or persistent diarrhea1
1CompletedTreatmentGiant Cell Glioblastoma / Glioblastomas / Gliosarcoma1
1CompletedTreatmentGlioblastoma Multiforme (GBM)3
1CompletedTreatmentGlioblastoma Multiforme (GBM) / Malignant Gliomas / Mixed Gliomas1
1CompletedTreatmentGlioblastoma Multiforme (GBM) / Melanoma / Recurrence of Solid Tumor1
1CompletedTreatmentGlioblastoma Multiforme/Anaplastic Astrocytoma1
1CompletedTreatmentGlioblastomas4
1CompletedTreatmentGlioblastomas / Gliosarcoma2
1CompletedTreatmentHER2 Positive / Metastatic Brain Tumors / Metastatic Breast Cancer (MBC)1
1CompletedTreatmentLeukemias2
1CompletedTreatmentMalignant Neoplasms of Brain1
1CompletedTreatmentMelanoma2
1CompletedTreatmentMelanoma / Neoplasms, Brain1
1CompletedTreatmentMetastatic Brain Tumors / Primary Brain Tumors1
1CompletedTreatmentMetastatic Melanoma2
1CompletedTreatmentNeoplasms Malignant / Refractory Tumors1
1CompletedTreatmentNeoplasms, Brain / Tumors, Central Nervous System1
1CompletedTreatmentNeuroblastomas1
1CompletedTreatmentPreviously Treated Childhood Rhabdomyosarcoma / Recurrent Childhood Brain Tumor / Recurrent Childhood Cerebellar Astrocytoma / Recurrent Childhood Cerebral Astrocytoma / Recurrent Childhood Ependymoma / Recurrent Childhood Malignant Germ Cell Tumor / Recurrent Childhood Medulloblastoma / Recurrent Childhood Rhabdomyosarcoma / Recurrent Childhood Soft Tissue Sarcoma / Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor / Recurrent Neuroblastoma / Recurrent Osteosarcoma1
1CompletedTreatmentProstate Cancer1
1CompletedTreatmentRefractory Solid Tumors in Children1
1CompletedTreatmentTumors1
1CompletedTreatmentTumors, Central Nervous System1
1CompletedTreatmentTumors, Solid2
1CompletedTreatmentUnspecified Adult Solid Tumor, Protocol Specific5
1CompletedTreatmentUnspecified Childhood Solid Tumor, Protocol Specific1
1Not Yet RecruitingTreatmentAnaplastic Astrocytoma, IDH-Mutant / Diffuse Astrocytoma, IDH-Mutant / IDH1 Gene Mutation / IDH2 Gene Mutation1
1Not Yet RecruitingTreatmentCancer of Brain / Glioblastoma Multiforme (GBM) / Glioblastomas / Neoplasms, Brain1
1Not Yet RecruitingTreatmentEwing's Sarcoma (ES) / Medulloblastomas / Neuroblastomas / Rhabdoid Tumors / Rhabdomyosarcomas / Tumors, Solid1
1Not Yet RecruitingTreatmentGlioblastomas1
1Not Yet RecruitingTreatmentGlioblastomas / IDH1 Gene Mutation / IDH2 Gene Mutation / Low Grade Glioma (LGG) / Malignant Gliomas / Recurrent Glioblastoma / Recurrent WHO Grade II Glioma / Recurrent WHO Grade III Glioma / WHO Grade II Glioma / WHO Grade III Glioma1
1Not Yet RecruitingTreatmentMalignant Glioma of Brain1
1RecruitingDiagnosticGliomas1
1RecruitingTreatmentAdult Glioblastoma / Recurrent Adult Brain Neoplasm / Recurrent Glioblastoma1
1RecruitingTreatmentAnaplastic Oligodendroglioma (AO) / Glioblastomas / Oligodendrogliomas1
1RecruitingTreatmentAstrocytoma, Grade III / Glioblastomas1
1RecruitingTreatmentAstrocytoma, Grade IV / Glioblastomas1
1RecruitingTreatmentChildhood Solid Neoplasm / Recurrent Central Nervous System Neoplasm / Recurrent Malignant Solid Neoplasm / Recurrent Solid Neoplasm / Refractory Central Nervous System Neoplasm / Refractory Malignant Solid Neoplasm1
1RecruitingTreatmentChildhood Solid Tumors1
1RecruitingTreatmentDiffuse Intrinsic Pontine Glioma (DIPG) / Ependymomas / Glioblastoma Multiforme (GBM) / Gliomas / Gliosarcoma / Malignant Brain Tumors / Medulloblastomas / Primary CNS Tumor1
1RecruitingTreatmentEwing's Sarcoma (ES)1
1RecruitingTreatmentGBM / Glioblastomas / Neoplasms, Brain1
1RecruitingTreatmentGlioblastoma Multiforme (GBM)1
1RecruitingTreatmentGlioblastoma Multiforme (GBM) / Glioblastomas2
1RecruitingTreatmentGlioblastoma Multiforme (GBM) / Gliomas1
1RecruitingTreatmentGlioblastoma Multiforme (Grade IV) of Cerebellum / Glioblastomas1
1RecruitingTreatmentGlioblastoma Multiforme, Adult1
1RecruitingTreatmentGlioblastoma, Adult1
1RecruitingTreatmentGlioblastomas2
1RecruitingTreatmentGlioblastomas / Gliomas2
1RecruitingTreatmentGlioblastomas / Malignant Gliomas1
1RecruitingTreatmentHigh Grade Glioma (HGG)1
1RecruitingTreatmentMalignancies / Neoplasms / Neuroendocrine Tumors / Tumors1
1RecruitingTreatmentNewly Diagnosed Glioblastoma1
1RecruitingTreatmentPrimary Brain Tumors / Tumors, Solid1
1RecruitingTreatmentRecurrent Central Nervous System Neoplasm / Recurrent Lymphoma / Recurrent Malignant Solid Neoplasm / Refractory Central Nervous System Neoplasm / Refractory Lymphomas / Refractory Malignant Solid Neoplasm1
1RecruitingTreatmentSarcomas1
1TerminatedTreatmentAdvanced Solid Tumors1
1TerminatedTreatmentAnaplastic Astrocytoma (AA) / Anaplastic Oligoastrocytoma / Anaplastic Oligodendroglioma (AO) / Glioblastomas / Gliosarcoma1
1TerminatedTreatmentAstrocytoma, Grade IV / Glioblastoma Multiforme (GBM)1
1TerminatedTreatmentBone Cancer / Kidney Tumors / Neoplasms / Neuroblastomas / Tumors, Solid1
1TerminatedTreatmentBrain Diseases / CNS Disease / Glioblastomas1
1TerminatedTreatmentBrain and Central Nervous System Tumors1
1TerminatedTreatmentBrain and Central Nervous System Tumors / Malignant Lymphomas / Unspecified Adult Solid Tumor, Protocol Specific1
1TerminatedTreatmentCentral Nervous System Neoplasms / Neoplasms Metastasis1
1TerminatedTreatmentGlioblastoma Multiforme (GBM)2
1TerminatedTreatmentGlioblastomas1
1TerminatedTreatmentGlioblastomas / Gliosarcoma1
1TerminatedTreatmentLeptomeningeal Metastases1
1TerminatedTreatmentMelanoma2
1TerminatedTreatmentMetastatic Brain Tumors1
1TerminatedTreatmentNeoplasms1
1Unknown StatusTreatmentBrain and Central Nervous System Tumors2
1Unknown StatusTreatmentGlioblastoma Multiforme (GBM)1
1Unknown StatusTreatmentMelanoma1
1Unknown StatusTreatmentMelanoma (Skin)2
1WithdrawnTreatmentFunctional Pancreatic Neuroendocrine Tumor / Malignant Somatostatinoma / Metastatic Adrenal Gland Pheochromocytoma / Metastatic Carcinoid Tumors / Multiple Endocrine Neoplasia Type 1 / Multiple Endocrine Neoplasia Type 2a / Multiple Endocrine Neoplasia Type 2B / Neuroendocrine Carcinoma of the Skin / Neuroendocrine Neoplasms / Non-Functional Pancreatic Neuroendocrine Tumor / Pancreatic Glucagonoma / Pancreatic Insulinoma / Recurrent Adrenal Cortex Carcinoma / Recurrent Adrenal Gland Pheochromocytoma / Recurrent Merkel Cell Carcinoma / Somatostatin-Producing Neuroendocrine Tumor / Stage III Adrenal Cortex Carcinoma / Stage III Thyroid Gland Medullary Carcinoma / Stage IIIA Merkel Cell Carcinoma / Stage IIIB Merkel Cell Carcinoma / Stage IV Adrenal Cortex Carcinoma / Stage IV Merkel Cell Carcinoma / Stage IVA Thyroid Gland Medullary Carcinoma / Stage IVB Thyroid Gland Medullary Carcinoma / Stage IVC Thyroid Gland Medullary Carcinoma / Thymic Carcinoid Tumor / VIP-Producing Neuroendocrine Tumor / Well Differentiated Adrenal Cortex Carcinoma / Zollinger-Ellison Syndrome1
1WithdrawnTreatmentGlioblastoma Multiforme (GBM)1
1WithdrawnTreatmentUnspecified Adult Solid Tumor, Protocol Specific1
1, 2Active Not RecruitingTreatmentAdult Giant Cell Glioblastoma / Adult Glioblastoma / Adult Gliosarcoma / Cognitive Side Effects of Cancer Therapy / Cognitive/Functional Effects1
1, 2Active Not RecruitingTreatmentAdult Glioblastoma2
1, 2Active Not RecruitingTreatmentAdult Glioblastoma / Adult Gliosarcoma / Glioblastomas / Gliosarcoma1
1, 2Active Not RecruitingTreatmentAdult Solid Neoplasm / Childhood Solid Neoplasm / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Central Nervous System Neoplasm / Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor / Recurrent Malignant Solid Neoplasm / Refractory Central Nervous System Neoplasm1
1, 2Active Not RecruitingTreatmentAnaplastic Gliomas / Glioblastoma Multiforme (GBM)1
1, 2Active Not RecruitingTreatmentBrain and Central Nervous System Tumors4
1, 2Active Not RecruitingTreatmentCancer of Brain and Nervous System / Glioblastoma Multiforme (GBM) / Glioblastomas1
1, 2Active Not RecruitingTreatmentGlioblastoma Multiforme (GBM) / Gliomas / Gliosarcoma / Malignant Brain Tumors1
1, 2Active Not RecruitingTreatmentGlioblastoma Multiforme (GBM) / Gliosarcoma1
1, 2Active Not RecruitingTreatmentGlioblastomas1
1, 2Active Not RecruitingTreatmentMetastatic Melanoma1
1, 2Active Not RecruitingTreatmentNeuroblastomas1
1, 2Active Not RecruitingTreatmentPatients With Newly Diagnosed Glioblastoma1
1, 2Active Not RecruitingTreatmentProgressive Neuroendocrine Tumors of pancreatic origin1
1, 2CompletedTreatmentAdult Ependymoblastoma / Adult Giant Cell Glioblastoma / Adult Glioblastoma / Adult Gliosarcoma / Adult Medulloblastoma / Adult Mixed Glioma / Adult Oligodendroglial Tumors / Adult Pineoblastoma / Adult Supratentorial Primitive Neuroectodermal Tumor (PNET)1
1, 2CompletedTreatmentAdult Giant Cell Glioblastoma / Adult Glioblastoma / Adult Gliosarcoma3
1, 2CompletedTreatmentAdvanced Melanoma / Melanoma1
1, 2CompletedTreatmentAnaplastic Astrocytoma (AA) / Brain Stem Gliomas / Childhood Mixed Glioma / Fibrillary Astrocytoma / Giant Cell Glioblastoma / Glioblastomas / Gliosarcoma / Untreated Childhood Anaplastic Astrocytoma / Untreated Childhood Brain Stem Glioma / Untreated Childhood Fibrillary Astrocytoma / Untreated Childhood Giant Cell Glioblastoma / Untreated Childhood Glioblastoma / Untreated Childhood Gliosarcoma1
1, 2CompletedTreatmentBrain and Central Nervous System Tumors1
1, 2CompletedTreatmentBrain and Central Nervous System Tumors / Cancer of the Ovary / Childhood Germ Cell Tumor / Head and Neck Carcinoma / Neuroblastomas / Renal Cancers / Sarcomas / Testicular germ cell tumour1
1, 2CompletedTreatmentEwing's Sarcoma (ES)1
1, 2CompletedTreatmentGlioblastoma Multiforme (GBM)1
1, 2CompletedTreatmentGlioblastoma Multiforme (GBM) / Glioblastomas / Gliosarcoma1
1, 2CompletedTreatmentGlioblastomas / Neoplasms, Brain1
1, 2CompletedTreatmentGliomas1
1, 2CompletedTreatmentIntraocular Melanoma / Melanoma (Skin)1
1, 2CompletedTreatmentMalignant Melanoma1
1, 2CompletedTreatmentMelanoma1
1, 2CompletedTreatmentMetastatic Brain Tumors / Neoplasms, Brain1
1, 2CompletedTreatmentMetastatic Cancers1
1, 2CompletedTreatmentMetastatic Melanoma3
1, 2CompletedTreatmentRecurrent Melanoma / Stage IV Skin Melanoma1
1, 2Not Yet RecruitingNot AvailableCytokine-Induced Killer Cells / Milignant Gliomas1
1, 2Not Yet RecruitingPreventionLung Cancer Non-Small Cell Cancer (NSCLC)1
1, 2Not Yet RecruitingTreatmentCancer of Colon / Cancer of Liver / Cancer of Pancreas / Cancer of Rectum / Cancer, Gall Bladder / Glioblastoma Multiforme (GBM) / Myeloma Multiple1
1, 2Not Yet RecruitingTreatmentGlioblastomas1
1, 2Not Yet RecruitingTreatmentGliomas2
1, 2RecruitingTreatmentAnaplastic Astrocytoma (AA) / Brain Stem Gliomas / Diffuse Intrinsic Pontine Glioma (DIPG) / DIPG / Glioblastoma Multiforme (GBM) / Glioma, Astrocytic / Gliosarcoma / Low-Grade Gliomas / Optic Nerve Glioma / Pilocytic Astrocytoma / Pilomyxoid Astrocytoma / Pleomorphic Xanthoastrocytoma1
1, 2RecruitingTreatmentAstrocytomas / Astroglioma / Glioblastomas / Gliosarcoma / Neoplasms, Brain1
1, 2RecruitingTreatmentBrain Cancer / Brain Metastasis / Cancer, Breast1
1, 2RecruitingTreatmentBrain Cancer / Brain Tumor Adult / Glioblastoma Multiforme (GBM) / Glioblastoma, Adult / Glioblastomas / Glioma of Brain / Malignancies / Neoplasms, Brain / Primary Brain Tumors1
1, 2RecruitingTreatmentBrain and Central Nervous System Tumors1
1, 2RecruitingTreatmentCarcinoma, Small Cell / Lung Cancer Small Cell Lung Cancer (SCLC) / Lung Cancers1
1, 2RecruitingTreatmentChildren, Adolescents and Young Adults With Refractory or Recurrent Malignancies1
1, 2RecruitingTreatmentGBM / Glioblastoma Multiforme (GBM) / Glioblastomas1
1, 2RecruitingTreatmentGlioblastoma Multiforme (GBM) / Glioblastomas / Malignant Gliomas1
1, 2RecruitingTreatmentGlioblastomas4
1, 2RecruitingTreatmentGlioblastomas / Gliosarcoma1
1, 2RecruitingTreatmentGlioblastomas / Gliosarcoma / Malignant Neoplasms of Eye Brain and Other Parts of Central Nervous System1
1, 2RecruitingTreatmentLocally Advanced or Metastatic Solid Tumors1
1, 2RecruitingTreatmentLung Cancer Small Cell Lung Cancer (SCLC)1
1, 2RecruitingTreatmentMalignant Gliomas / PARP Inhibitor / Radiotherapy1
1, 2RecruitingTreatmentPancreatic Alpha Cell Carcinoma / Pancreatic Beta Islet Cell Carcinoma / Pancreatic Delta Cell Carcinoma / Pancreatic G-cell Carcinoma / Recurrent Islet Cell Carcinoma1
1, 2SuspendedTreatmentGlioblastoma Multiforme (GBM)1
1, 2TerminatedTreatmentActivation of the Sonic Hedgehog (SHH) Pathway / Histologically Confirmed Medulloblastoma1
1, 2TerminatedTreatmentAstrocytomas / Glioblastoma Multiforme (GBM) / Gliomas / Neoplasms, Brain1
1, 2TerminatedTreatmentBrain Cancer / Glioblastoma Multiforme (GBM)1
1, 2TerminatedTreatmentBrain and Central Nervous System Tumors / Melanoma / Tumors, Solid1
1, 2TerminatedTreatmentGlioblastoma Multiforme (GBM)1
1, 2TerminatedTreatmentGlioblastomas (GBM)1
1, 2TerminatedTreatmentMelanoma1
1, 2TerminatedTreatmentMetastatic Malignant Melanoma2
1, 2TerminatedTreatmentMetastatic Melanoma1
1, 2TerminatedTreatmentNeuroblastomas1
1, 2Unknown StatusTreatmentBrain and Central Nervous System Tumors2
1, 2Unknown StatusTreatmentGlioblastoma Multiforme (GBM)3
1, 2Unknown StatusTreatmentMelanoma (Skin)1
1, 2WithdrawnTreatmentBrain and Central Nervous System Tumors1
1, 2WithdrawnTreatmentMetastatic Brain Tumors / Metastatic Melanoma1
2Active Not RecruitingTreatmentAdult Anaplastic Astrocytoma / Adult Anaplastic Ependymoma / Adult Anaplastic Oligodendroglioma / Adult Giant Cell Glioblastoma / Adult Glioblastoma1
2Active Not RecruitingTreatmentAdult Brain Glioblastoma1
2Active Not RecruitingTreatmentAdult Glioblastoma / Adult Gliosarcoma1
2Active Not RecruitingTreatmentAnaplastic Glioma of Brain / Loss of Chromosomes 1p/19q1
2Active Not RecruitingTreatmentBRCA1 Gene Mutation / Brca2 Gene Mutation / Cancer, Breast / Metastatic Breast Cancer (MBC)1
2Active Not RecruitingTreatmentBrain and Central Nervous System Tumors3
2Active Not RecruitingTreatmentCarcinoma, Islet Cell / Gastrinoma / Glucagonoma / Insulinoma / Pancreatic Polypeptide Tumor / Recurrent Islet Cell Carcinoma / Somatostatinoma1
2Active Not RecruitingTreatmentCarcinoma, Small Cell1
2Active Not RecruitingTreatmentDesmoplastic Small Round Cell Tumor (DSRCT) / Ewing Sarcoma of Bone or Soft Tissue / Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor / Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor1
2Active Not RecruitingTreatmentEwing's Sarcoma (ES)1
2Active Not RecruitingTreatmentGastrinoma / Glucagonoma / Insulinoma / Pancreatic Polypeptide Tumor / Recurrent Islet Cell Carcinoma / Recurrent Pancreatic Cancer / Somatostatinoma / Stage III Pancreatic Cancer / Stage IV Pancreatic Cancer1
2Active Not RecruitingTreatmentGiant Cell Glioblastoma / Glioblastomas / Gliosarcoma1
2Active Not RecruitingTreatmentGlioblastoma Multiforme (GBM)1
2Active Not RecruitingTreatmentGlioblastoma Multiforme (GBM) / Glioblastomas / Gliosarcoma / Malignant Gliomas1
2Active Not RecruitingTreatmentGlioblastoma Multiforme (GBM) / Gliosarcoma1
2Active Not RecruitingTreatmentGlioblastomas1
2Active Not RecruitingTreatmentGlioblastomas / Gliosarcoma1
2Active Not RecruitingTreatmentGlioblastomas / Gliosarcoma / Grade 4 Malignant Glioma / Malignant Gliomas1
2Active Not RecruitingTreatmentGliomas / High Grade Glioma (HGG)1
2Active Not RecruitingTreatmentIris Melanoma / Medium/Large Size Posterior Uveal Melanoma / Ocular Melanoma With Extraocular Extension / Recurrent Uveal Melanoma / Small Size Posterior Uveal Melanoma / Stage IV Uveal Melanoma1
2Active Not RecruitingTreatmentMalignant Melanoma2
2Active Not RecruitingTreatmentMetastatic Breast Cancer (MBC)1
2Active Not RecruitingTreatmentNeoplasms, Brain / Tumors, Central Nervous System1
2Active Not RecruitingTreatmentNeuroblastomas1
2Active Not RecruitingTreatmentNeuroendocrine Tumours1
2Active Not RecruitingTreatmentNeurofibromatosis 11
2Active Not RecruitingTreatmentRecurrent Childhood Medulloblastoma / Recurrent Childhood Pineoblastoma / Recurrent Childhood Supratentorial Embryonal Tumor, Not Otherwise Specified / Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor1
2Active Not RecruitingTreatmentRecurrent Melanoma / Stage IV Melanoma1
2Active Not RecruitingTreatmentRhabdomyosarcomas1
2Active Not RecruitingTreatmentTumors, Central Nervous System1
2CompletedTreatmentAcute Myeloid Leukemia With 11q23-abnormality in Relapse1
2CompletedTreatmentAdult Giant Cell Glioblastoma / Adult Glioblastoma / Adult Gliosarcoma1
2CompletedTreatmentAdult Glioblastoma / Adult Gliosarcoma / Recurrent Adult Brain Neoplasm / Recurrent Adult Brain Tumor1
2CompletedTreatmentAdult Rhabdomyosarcoma / Childhood Alveolar Rhabdomyosarcoma / Childhood Embryonal Rhabdomyosarcoma / Metastatic Childhood Soft Tissue Sarcoma / Stage IV Adult Soft Tissue Sarcoma / Untreated Childhood Rhabdomyosarcoma1
2CompletedTreatmentAnaplastic Astrocytoma (AA) / Glioblastomas1
2CompletedTreatmentAnaplastic Glioma of Brain / Brain Cancer / Glioblastoma Multiforme (GBM)1
2CompletedTreatmentAnaplastic Gliomas / Glioblastoma Multiforme (GBM)1
2CompletedTreatmentAnaplastic Oligoastrocytoma / Anaplastic Oligodendroglioma (AO)1
2CompletedTreatmentAnaplastic Oligodendroglioma (AO) / Oligoastrocytoma, Mixed1
2CompletedTreatmentAstrocytomas1
2CompletedTreatmentAstrocytomas / Glioblastomas / Gliomas / Oligodendrogliomas1
2CompletedTreatmentAstrocytomas / Glioblastomas / Oligodendrogliomas / Recurrent Brain Tumors1
2CompletedTreatmentAstrocytomas / Gliomas / Oligodendrogliomas1
2CompletedTreatmentBrain and Central Nervous System Tumors22
2CompletedTreatmentBrain and Central Nervous System Tumors / Neuroblastomas1
2CompletedTreatmentBrain and Central Nervous System Tumors / Unspecified Adult Solid Tumor, Protocol Specific1
2CompletedTreatmentCNS Tumor, Adult2
2CompletedTreatmentCancer of the Ovary1
2CompletedTreatmentCancer of the Ovary / Testicular germ cell tumour1
2CompletedTreatmentCancer, Breast / Metastatic Cancers1
2CompletedTreatmentCancer, Breast / Soft Tissue Sarcoma (STS)1
2CompletedTreatmentCentral Nervous System Tumor, Pediatric1
2CompletedTreatmentCentral Nervous System Tumor, Pediatric / Neuroblastomas1
2CompletedTreatmentColorectal Cancers1
2CompletedTreatmentDiffuse Intrinsic Pontine Glioma (DIPG)1
2CompletedTreatmentEfficacy and Safety1
2CompletedTreatmentGanglioneuroblastoma / Recurrent Neuroblastoma1
2CompletedTreatmentGastroenteropancreatic Neuroendocrine Tumors1
2CompletedTreatmentGastrointestinal Stromal Tumors1
2CompletedTreatmentGlioblastoma Multiforme (GBM)16
2CompletedTreatmentGlioblastoma Multiforme (GBM) / Gliosarcoma2
2CompletedTreatmentGlioblastoma Multiforme (GBM) / Primary Brain Tumors1
2CompletedTreatmentGlioblastomas7
2CompletedTreatmentGlioblastomas / Gliomas1
2CompletedTreatmentGlioblastomas / Gliosarcoma4
2CompletedTreatmentGlioblastomas / Gliosarcoma / Neoplasms, Brain1
2CompletedTreatmentGlioblastomas / Primary Brain Tumors1
2CompletedTreatmentGliomas3
2CompletedTreatmentGliomas / Medulloblastomas1
2CompletedTreatmentHigh Grade Gliomas / Neoplasms, Brain1
2CompletedTreatmentHigh-Grade Gliomas1
2CompletedTreatmentIntraocular Melanoma / Melanoma (Skin)2
2CompletedTreatmentLeukemia Acute Myeloid Leukemia (AML) / Myelodysplastic Syndrome1
2CompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC) / Melanoma / Metastases of Central Nervous System / Neoplasms, Breast1
2CompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC) / Neoplasms Metastasis / Neoplasms, Brain1
2CompletedTreatmentLung Cancers5
2CompletedTreatmentLung Cancers / Metastatic Cancers2
2CompletedTreatmentMalignancies / Melanoma / Skin Cancers1
2CompletedTreatmentMalignancies / Metastatic Brain Tumors1
2CompletedTreatmentMalignant Gliomas1
2CompletedTreatmentMalignant Lymphomas1
2CompletedTreatmentMalignant Melanoma1
2CompletedTreatmentMalignant Neoplasms of Brain1
2CompletedTreatmentMedulloblastomas1
2CompletedTreatmentMelanoma4
2CompletedTreatmentMelanoma (Skin)5
2CompletedTreatmentMelanoma / Metastatic Melanoma / Skin Cancers1
2CompletedTreatmentMelanoma / Skin Cancers1
2CompletedTreatmentMetastatic Brain Tumors1
2CompletedTreatmentMetastatic Cancers1
2CompletedTreatmentMetastatic Melanoma1
2CompletedTreatmentMyeloid Leukemias1
2CompletedTreatmentNaive Unresectable Glioblastoma1
2CompletedTreatmentNeoplasms, Brain2
2CompletedTreatmentNeoplasms, Brain / Neuroblastomas / Tumors, Solid1
2CompletedTreatmentNeoplasms, Brain / Spinal Cord Tumors1
2CompletedTreatmentNeoplasms, Brain / Tumors, Central Nervous System1
2CompletedTreatmentNeuroblastomas2
2CompletedTreatmentNeuroendocrine Tumors3
2CompletedTreatmentRecurrent Central Nervous System Neoplasm1
2CompletedTreatmentRecurrent Glioblastoma Multiforme2
2CompletedTreatmentRecurrent Glioblastoma Multiforme / Recurrent Gliosarcoma1
2CompletedTreatmentRecurrent Melanoma / Stage IV Melanoma / Tumors Metastatic to Brain1
2CompletedTreatmentRecurrent Small Cell Lung Carcinoma1
2CompletedTreatmentRecurrent Uveal Melanoma / Stage III Uveal Melanoma / Stage III Uveal Melanoma AJCC v7 / Stage IIIA Uveal Melanoma / Stage IIIA Uveal Melanoma AJCC v7 / Stage IIIB Uveal Melanoma / Stage IIIB Uveal Melanoma AJCC v7 / Stage IIIC Uveal Melanoma / Stage IIIC Uveal Melanoma AJCC v7 / Stage IV Uveal Melanoma / Stage IV Uveal Melanoma AJCC v71
2CompletedTreatmentSolid Tumor Cancers1
2Enrolling by InvitationTreatmentLung Cancer Small Cell Lung Cancer (SCLC) / Metastatic Carcinoma1
2Not Yet RecruitingTreatmentBrain Metastasis / Radiation Therapy Complication1
2Not Yet RecruitingTreatmentCapecitabine / Neuroendocrine Carcinomas / Neuroendocrine Tumors / Temozolomide1
2Not Yet RecruitingTreatmentGlioblastoma Multiforme (GBM)1
2Not Yet RecruitingTreatmentGlioblastomas2
2Not Yet RecruitingTreatmentGlioma of Brain1
2Not Yet RecruitingTreatmentGrade I Neuroendocrine Carcinoma / Grade II Neuroendocrine Carcinoma / Grade III Neuroendocrine Carcinoma / Large Cell Neuroendocrine Carcinoma / Lung Cancer Small Cell Lung Cancer (SCLC) / Lung carcinoma cell type unspecified stage IV / Metastatic Neuroendocrine Carcinoma / Metastatic Small Cell Lung Cancer / Neuroendocrine Carcinomas / Neuroendocrine Tumors / Recurrent Small Cell Lung Carcinoma / Refractory Small Cell Lung Carcinoma1
2Not Yet RecruitingTreatmentMalignant Neoplasm of Pancreas1
2Not Yet RecruitingTreatmentMicrosatellite Instability / Neoplasms, Colorectal1
2Not Yet RecruitingTreatmentPrimary Central Nervous System Lymphoma (PCNSL)1
2Not Yet RecruitingTreatmentRecurrent Extensive Stage Small Cell Lung Carcinoma / Refractory Extensive Stage Small Cell Lung Carcinoma1
2RecruitingTreatment1p/19q Co-deletion / Anaplastic Astrocytoma (AA) / Diffuse Astrocytoma / Gliomas / IDH1 Gene Mutation / IDH2 Gene Mutation / Oligoastrocytoma / Oligodendrogliomas / WHO Grade III Glioma1
2RecruitingTreatmentAdult Giant Cell Glioblastoma / Adult Glioblastoma / Adult Gliosarcoma1
2RecruitingTreatmentAdvanced Melanoma1
2RecruitingTreatmentAnaplastic Astrocytoma (AA) / Glioblastomas / Malignant Gliomas1
2RecruitingTreatmentAstrocytoma, Grade IV / Giant Cell Glioblastoma / Glioblastoma Multiforme (GBM) / Glioblastomas1
2RecruitingTreatmentAstrocytomas / Oligoastrocytoma / Oligodendrogliomas1
2RecruitingTreatmentChildhood Brain Stem Neoplasm1
2RecruitingTreatmentColorectal Large Cell Neuroendocrine Carcinoma / Esophageal Large Cell Neuroendocrine Carcinoma / Gallbladder Large Cell Neuroendocrine Carcinoma / Gastric Large Cell Neuroendocrine Carcinoma / Gastric Neuroendocrine Carcinoma / Intestinal Neuroendocrine Carcinoma / Pancreatic Large Cell Neuroendocrine Carcinoma / Pancreatic Neuroendocrine Carcinoma / Small Intestinal Large Cell Neuroendocrine Carcinoma1
2RecruitingTreatmentEpendymomas / Ewing's Sarcoma (ES) / Gliomas / Medulloblastomas / Neuroectodermal Tumors / Rhabdomyosarcomas / Sarcoma, Osteogenic / Wilms' tumor1
2RecruitingTreatmentEwing's Sarcoma (ES)2
2RecruitingTreatmentExtensive Stage Small Cell Lung Cancer1
2RecruitingTreatmentExtrapancreatic Neuroendocrine Tumor1
2RecruitingTreatmentGastrointestinal Stromal Tumors / GIST / Malignancies / Sdh / Temozolomide1
2RecruitingTreatmentGlioblastoma Multiforme (GBM)5
2RecruitingTreatmentGlioblastoma Multiforme (GBM) / Glioblastomas1
2RecruitingTreatmentGlioblastoma Multiforme of Brain1
2RecruitingTreatmentGlioblastoma With Primitive Neuronal Component / Glioblastomas / Gliosarcoma / Malignant Gliomas / Oligodendroglial Component Present1
2RecruitingTreatmentGlioblastoma, WHO Grade IV / Glioblastomas1
2RecruitingTreatmentGlioblastomas5
2RecruitingTreatmentGlioblastomas / Gliosarcoma1
2RecruitingTreatmentGlioblastomas / Recurrent Glioblastoma1
2RecruitingTreatmentGliomas2
2RecruitingTreatmentHigh Grade Glioma (HGG)1
2RecruitingTreatmentHigh Grade Glioma, Glioblastoma1
2RecruitingTreatmentHigh Grade Recurrent Glioma and Newly Diagnosed Glioblastoma1
2RecruitingTreatmentLow Grade Glioma (LGG) / Oligoastrocytoma, Mixed / Oligodendrogliomas / WHO Grade II Astrocytomas1
2RecruitingTreatmentMedulloblastomas1
2RecruitingTreatmentMetastatic Colorectal Cancers1
2RecruitingTreatmentMidgut Neuroendocrine Tumours / Progressive Neuroendocrine Tumors of pancreatic origin1
2RecruitingTreatmentNeuroblastomas1
2RecruitingTreatmentNeuroendocrine Carcinomas2
2RecruitingTreatmentNeuroendocrine Tumors1
2RecruitingTreatmentNewly Diagnosed Ewing Sarcoma1
2RecruitingTreatmentPinealoblastoma1
2RecruitingTreatmentPrimary Central Nervous System Lymphoma (PCNSL)2
2RecruitingTreatmentProgressive Neuroendocrine Tumors of pancreatic origin1
2RecruitingTreatmentRecurrent Neuroblastoma1
2SuspendedDiagnosticAdult Anaplastic (Malignant) Meningioma / Adult Anaplastic Astrocytoma / Adult Anaplastic Ependymoma / Adult Brain Stem Glioma / Adult Choroid Plexus Neoplasm / Adult Ependymoblastoma / Adult Giant Cell Glioblastoma / Adult Glioblastoma / Adult Gliosarcoma / Adult Medulloblastoma / Adult Mixed Glioma / Adult Papillary Meningioma / Adult Pineal Gland Astrocytoma / Adult Pineoblastoma / Adult Primary Melanocytic Lesion of Meninges / Adult Supratentorial Primitive Neuroectodermal Tumor / Malignant Gliomas1
2SuspendedTreatmentGlioblastomas / Gliosarcoma / Supratentorial Glioblastoma1
2TerminatedDiagnosticMalignant Gliomas1
2TerminatedPreventionNeoplasms, Brain / Neoplasms, Breast / Second Neoplasm1
2TerminatedTreatmentAdenocarcinomas / Carcinoma, Large Cell / Lung Cancer Non-Small Cell Cancer (NSCLC) / Squamous Cell Carcinoma (SCC)1
2TerminatedTreatmentAstrocytomas / Gliomas / Oligoastrocytoma / Oligodendrogliomas1
2TerminatedTreatmentB-Cell Lymphoma Originating in the CNS1
2TerminatedTreatmentBone Cancer / Ewing's Sarcoma (ES)1
2TerminatedTreatmentBrain Cancer1
2TerminatedTreatmentBrain and Central Nervous System Tumors1
2TerminatedTreatmentGlioblastoma Multiforme (GBM)2
2TerminatedTreatmentGlioblastoma Multiforme (GBM) / High-Grade Gliomas1
2TerminatedTreatmentGlioblastomas1
2TerminatedTreatmentGlioblastomas / Gliosarcoma1
2TerminatedTreatmentGliomas1
2TerminatedTreatmentHepatocellular,Carcinoma1
2TerminatedTreatmentLeptomeningeal Metastases / Neoplasms, Brain / Tumors, Central Nervous System1
2TerminatedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
2TerminatedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC) / Neoplasm Metastases / Neoplasms, Brain1
2TerminatedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC) / Neoplasms, Colorectal / Neoplasms, Esophageal / Neoplasms, Head and Neck1
2TerminatedTreatmentMalignant Lymphomas2
2TerminatedTreatmentMalignant Melanoma1
2TerminatedTreatmentMelanoma2
2TerminatedTreatmentMelanoma (Skin)1
2TerminatedTreatmentMelanoma (Skin) / Metastatic Cancers1
2TerminatedTreatmentMetastatic Brain Tumors1
2TerminatedTreatmentRetinoblastoma1
2TerminatedTreatmentUnresectable Stage III Melanoma / Wild Type BRAF Stage IV Melanoma1
2TerminatedTreatmentRefractory Small cell lung cancer1
2Unknown StatusTreatmentBrain and Central Nervous System Tumors5
2Unknown StatusTreatmentCancer of the Ovary / Endometrial Cancers / Sarcomas1
2Unknown StatusTreatmentCancer, Breast1
2Unknown StatusTreatmentCancer, Breast / Metastatic Cancers1
2Unknown StatusTreatmentCentral Nervous System (CNS) Metastases / Metastatic Brain Tumors1
2Unknown StatusTreatmentGlioblastomas2
2Unknown StatusTreatmentGliomas2
2Unknown StatusTreatmentIntraocular Melanoma1
2Unknown StatusTreatmentLung Cancer and Breast Cancer Patients With Brain Metastases1
2Unknown StatusTreatmentMalignant Gliomas1
2Unknown StatusTreatmentMalignant Lymphomas1
2Unknown StatusTreatmentMalignant Melanoma1
2Unknown StatusTreatmentMelanoma1
2Unknown StatusTreatmentMelanoma (Skin)1
2Unknown StatusTreatmentNewly Diagnosed Non Methylated Glioblastoma Multiforme Grade 41
2Unknown StatusTreatmentNewly Diagnosed Supratentorial Malignant Glioma1
2Unknown StatusTreatmentPrimary Central Nervous System Lymphoma (PCNSL)1
2Unknown StatusTreatmentSarcomas1
2Unknown StatusTreatmentTumors, Central Nervous System2
2WithdrawnTreatmentBrain Diseases / CNS Disease / Glioblastomas1
2WithdrawnTreatmentBrain and Central Nervous System Tumors2
2WithdrawnTreatmentBrain and Central Nervous System Tumors / Neuroblastomas / Retinoblastoma / Sarcomas1
2WithdrawnTreatmentCancer of the Ovary1
2WithdrawnTreatmentGlioblastomas / Gliosarcoma1
2WithdrawnTreatmentLung Cancers / Metastatic Cancers1
2WithdrawnTreatmentMelanoma / Neoplasms, Brain1
2WithdrawnTreatmentSoft Tissue Sarcoma (STS)1
2, 3Active Not RecruitingTreatmentAnaplastic Astrocytoma (AA) / Glioblastoma Multiforme (GBM)1
2, 3Active Not RecruitingTreatmentGlioblastomas / Gliosarcoma1
2, 3CompletedTreatmentBrain Stem Gliomas / Cerebral Astrocytoma / Childhood Cerebellar Anaplastic Astrocytoma / Childhood Cerebral Anaplastic Astrocytoma / Childhood Spinal Cord Neoplasm / Untreated Childhood Brain Stem Glioma / Untreated Childhood Cerebral Astrocytoma1
2, 3CompletedTreatmentEpendymomas / Medulloblastomas / Recurrent Brain Tumors / Supratentorial PNETs1
2, 3Not Yet RecruitingTreatmentGlioblastomas1
2, 3RecruitingTreatmentExtensive-Stage Small Cell Lung Cancer1
2, 3RecruitingTreatmentGlioblastomas1
3Active Not RecruitingTreatmentBrain and Central Nervous System Tumors1
3Active Not RecruitingTreatmentBrain and Central Nervous System Tumors / Neurologic toxicity1
3CompletedTreatmentAdult Giant Cell Glioblastoma / Adult Glioblastoma / Adult Gliosarcoma / Cognitive Side Effects of Cancer Therapy / Glioblastomas / Gliosarcoma / Supratentorial Glioblastoma1
3CompletedTreatmentAnaplastic Astrocytoma (AA) / Glioblastomas1
3CompletedTreatmentAnaplastic Astrocytoma (AA) / Oligoastrocytoma / Oligodendrogliomas1
3CompletedTreatmentAstrocytomas / Glioblastomas1
3CompletedTreatmentBrain and Central Nervous System Tumors5
3CompletedTreatmentGiant Cell Glioblastoma / Glioblastoma With Oligodendroglial Component / Glioblastomas / Gliosarcoma / Small Cell Glioblastoma1
3CompletedTreatmentGlioblastoma Multiforme (GBM)1
3CompletedTreatmentGlioblastomas5
3CompletedTreatmentMelanoma2
3CompletedTreatmentMetastatic Melanoma1
3Not Yet RecruitingTreatmentLow-Grade Gliomas / Phase III / Temozolomide / Wait or Treat1
3RecruitingTreatmentAnaplastic Astrocytoma (AA) / Anaplastic Oligoastrocytoma / Glioblastomas1
3RecruitingTreatmentAnaplastic Astrocytoma WHO Grade III / Diffuse Intrinsic Pontine Glioma (DIPG) / Diffuse Midline Glioma Histone 3 K27M WHO Grade IV / Glioblastoma WHO Grade IV / Gliomatosis Cerebri1
3RecruitingTreatmentAnaplastic Astrocytoma of Brain / Glioblastoma Multiforme of Brain1
3RecruitingTreatmentAstrocytomas / Oligodendroastrocytoma / Oligodendrogliomas1
3RecruitingTreatmentBrain Cancer1
3RecruitingTreatmentBrain and Central Nervous System Tumors1
3RecruitingTreatmentCancer - Glioblastoma / Glioblastoma Multiforme (GBM)1
3RecruitingTreatmentEwing Family of Tumors / Ewing's Sarcoma (ES) / Ewing's Tumor Metastatic / Metastatic Ewing's Sarcoma1
3RecruitingTreatmentGlioblastoma Multiforme (GBM) / Glioblastomas / Gliosarcoma1
3RecruitingTreatmentGlioblastomas1
3RecruitingTreatmentGlioblastomas / Progression / Recurrences1
3RecruitingTreatmentNeoplasms, Brain1
3RecruitingTreatmentNewly Diagnosed Glioblastoma1
3RecruitingTreatmentPrimary Central Nervous System Lymphoma (PCNSL)1
3SuspendedTreatmentBrain Cancer / Choroid Plexus Tumors1
3TerminatedTreatmentAnaplastic Astrocytoma (AA) / Glioblastomas1
3TerminatedTreatmentAstrocytomas / Oligoastrocytoma / Oligodendrogliomas1
3TerminatedTreatmentGlioblastoma Multiforme (GBM)1
3TerminatedTreatmentMelanoma (Skin) / Metastatic Cancers1
3TerminatedTreatmentMetastatic Malignant Neoplasm in the Brain / Non-Small Cell Lung Cancer Recurrent / Recurrent Non-Small Cell Lung Carcinoma / Stage IV Non-Small Cell Lung Cancer / Stage IV Non-Small Cell Lung Cancer AJCC v7 / Tumors Metastatic to Brain1
3Unknown StatusNot AvailableLung Cancer Non-Small Cell Cancer (NSCLC) / Neoplasms Metastasis1
3Unknown StatusTreatmentBrain and Central Nervous System Tumors1
3WithdrawnTreatmentOptic Nerve Glioma1
3WithdrawnTreatmentRecurrent Glioblastoma1
4CompletedTreatmentBrain Neoplasms, Primary Malignant1
4CompletedTreatmentGlioblastomas1
4Not Yet RecruitingNot AvailableAdvanced Milignant Gliomas / Cytokine-Induced Killer Cells1
Not AvailableActive Not RecruitingTreatmentRecurrent Childhood Brain Tumor1
Not AvailableCompletedNot AvailableAstrocytomas / Glioblastomas / Gliomas1
Not AvailableCompletedNot AvailableAstrocytomas / Gliomas1
Not AvailableCompletedNot AvailableGlioblastomas3
Not AvailableCompletedDiagnosticAdult Glioblastoma / Depression / Recurrent Adult Brain Tumor1
Not AvailableCompletedTreatmentBrain and Central Nervous System Tumors1
Not AvailableCompletedTreatmentBrain and Central Nervous System Tumors / Malignant Lymphomas1
Not AvailableCompletedTreatmentGlioblastoma Mutliforme1
Not AvailableCompletedTreatmentNeoplasms, Brain / Tumors, Central Nervous System1
Not AvailableNot Yet RecruitingTreatmentRecurrent High-grade Glioma1
Not AvailableRecruitingNot AvailableGlioblastomas1
Not AvailableSuspendedTreatmentAdvanced Malignant Solid Neoplasm / Neoplasms / Neoplasms, Advanced Solid / Recurrent Malignant Solid Neoplasm / Recurrent Solid Neoplasm1
Not AvailableTerminatedNot AvailableBrain and Central Nervous System Tumors1
Not AvailableTerminatedNot AvailableBrain and Central Nervous System Tumors / Thrombocytopenias1
Not AvailableTerminatedNot AvailableGlioblastomas1
Not AvailableTerminatedDiagnosticGliomas1
Not AvailableWithdrawnNot AvailableAstrocytoma, Grade IV / Giant Cell Glioblastoma / Glioblastoma Multiforme (GBM)1
Not AvailableWithdrawnTreatmentMalignant Lymphomas / Tumors, Central Nervous System1

Pharmacoeconomics

Manufacturers
  • Schering corp
  • Barr laboratories inc
Packagers
  • Baxter International Inc.
  • Physicians Total Care Inc.
  • Schering Corp.
  • Schering-Plough Inc.
  • University Of Iowa Pharmaceuticals
Dosage forms
FormRouteStrength
CapsuleOral180 mg
CapsuleOral100 mg
CapsuleOral140 mg
CapsuleOral20 mg
CapsuleOral250 mg
CapsuleOral5 mg
Injection, powder, for solutionIntravenous2.5 mg/ml
Powder, for solutionIntravenous100 mg
CapsuleOral100 mg/1
CapsuleOral180 mg/1
CapsuleOral20 mg/1
CapsuleOral250 mg/1
CapsuleOral5 mg/1
Injection, powder, lyophilized, for solutionIntravenous100 mg/40mL
Injection, powder, lyophilized, for solutionIntravenous2.5 mg/1mL
CapsuleOral140 mg/1
CapsuleOral180 1/1
Prices
Unit descriptionCostUnit
Temodar 250 mg capsule466.11USD capsule
Temodar 180 mg capsule401.53USD capsule
Temodar 100 mg capsule223.07USD capsule
Temodar 20 mg capsule44.62USD capsule
Temodar 5 mg capsule10.84USD capsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5260291No1993-11-092013-08-11Us
CA2476494No2010-04-272023-02-20Canada
CA2066313No2002-08-202012-04-16Canada
US6987108No2006-01-172023-09-08Us
US7786118No2010-08-312023-02-21Us
US8623868No2014-01-072023-02-21Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)212 °CNot Available
logP-2.8Not Available
Predicted Properties
PropertyValueSource
Water Solubility5.09 mg/mLALOGPS
logP-1ALOGPS
logP-0.28ChemAxon
logS-1.6ALOGPS
pKa (Strongest Acidic)10.51ChemAxon
pKa (Strongest Basic)-3.6ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area105.94 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity47.86 m3·mol-1ChemAxon
Polarizability16.88 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.9879
Caco-2 permeable+0.5608
P-glycoprotein substrateNon-substrate0.7228
P-glycoprotein inhibitor INon-inhibitor0.9255
P-glycoprotein inhibitor IINon-inhibitor0.9823
Renal organic cation transporterNon-inhibitor0.8822
CYP450 2C9 substrateNon-substrate0.7948
CYP450 2D6 substrateNon-substrate0.8695
CYP450 3A4 substrateNon-substrate0.5855
CYP450 1A2 substrateNon-inhibitor0.8134
CYP450 2C9 inhibitorNon-inhibitor0.9753
CYP450 2D6 inhibitorNon-inhibitor0.9479
CYP450 2C19 inhibitorNon-inhibitor0.9522
CYP450 3A4 inhibitorNon-inhibitor0.9571
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9954
Ames testNon AMES toxic0.5322
CarcinogenicityNon-carcinogens0.9412
BiodegradationNot ready biodegradable0.5172
Rat acute toxicity2.5279 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.7553
hERG inhibition (predictor II)Non-inhibitor0.9242
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as imidazotetrazines. These are organic polycyclic compounds containing an imidazole ring fused to a tetrazine ring. Imidazole is 5-membered ring consisting of three carbon atoms, and two nitrogen centers at the 1- and 3-positions. Tetrazine is a six-membered aromatic heterocycle made up of four nitrogen atoms and a two carbon atoms.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Imidazotetrazines
Sub Class
Not Available
Direct Parent
Imidazotetrazines
Alternative Parents
2-heteroaryl carboxamides / Carbonylimidazoles / Tetrazines / N-substituted imidazoles / Vinylogous amides / Heteroaromatic compounds / Primary carboxylic acid amides / Azacyclic compounds / Organopnictogen compounds / Organooxygen compounds
show 3 more
Substituents
Imidazotetrazine / 2-heteroaryl carboxamide / Imidazole-4-carbonyl group / N-substituted imidazole / Tetrazine / Azole / Imidazole / Heteroaromatic compound / Vinylogous amide / Carboxamide group
show 11 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
monocarboxylic acid amide, triazene derivative, imidazotetrazine (CHEBI:72564)

Targets

1. DNA
Kind
Nucleotide
Organism
Human
Pharmacological action
Yes
Actions
Cross-linking/alkylation
General Function:
Used for biological information storage.
Specific Function:
DNA contains the instructions needed for an organism to develop, survive and reproduce.
Molecular Weight:
2.15 x 1012 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Zaremba T, Curtin NJ: PARP inhibitor development for systemic cancer targeting. Anticancer Agents Med Chem. 2007 Sep;7(5):515-23. [PubMed:17896912]
  4. Dinca EB, Sarkaria JN, Schroeder MA, Carlson BL, Voicu R, Gupta N, Berger MS, James CD: Bioluminescence monitoring of intracranial glioblastoma xenograft: response to primary and salvage temozolomide therapy. J Neurosurg. 2007 Sep;107(3):610-6. [PubMed:17886562]
  5. Marchesi F, Turriziani M, Tortorelli G, Avvisati G, Torino F, De Vecchis L: Triazene compounds: mechanism of action and related DNA repair systems. Pharmacol Res. 2007 Oct;56(4):275-87. Epub 2007 Aug 9. [PubMed:17897837]
  6. Neyns B, Tosoni A, Hwu WJ, Reardon DA: Dose-dense temozolomide regimens: antitumor activity, toxicity, and immunomodulatory effects. Cancer. 2010 Jun 15;116(12):2868-77. doi: 10.1002/cncr.25035. [PubMed:20564393]
  7. Wick W, Platten M, Weller M: New (alternative) temozolomide regimens for the treatment of glioma. Neuro Oncol. 2009 Feb;11(1):69-79. doi: 10.1215/15228517-2008-078. Epub 2008 Sep 4. [PubMed:18772354]
  8. Natelson EA, Pyatt D: Temozolomide-induced myelodysplasia. Adv Hematol. 2010;2010:760402. doi: 10.1155/2010/760402. Epub 2010 Mar 4. [PubMed:20224797]
  9. Friedman HS, Kerby T, Calvert H: Temozolomide and treatment of malignant glioma. Clin Cancer Res. 2000 Jul;6(7):2585-97. [PubMed:10914698]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]

Drug created on June 13, 2005 07:24 / Updated on December 18, 2018 05:46