Displaying drugs 3601 - 3625 of 11300 in total
Eszopiclone
Eszopiclone, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic drug used to treat insomnia. It is the active stereoisomer of zopiclone, belonging to the class of drugs known as cyclopyrrolones.[A179638,L6850] Cyclopyrrolone drugs demonstrate high efficacy and low toxicity , offering a safer alternative to other drugs used...
Approved
Investigational
Matched Description: … Eszopiclone, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic drug ... [A179638,L6850] Cyclopyrrolone drugs demonstrate high efficacy and low toxicity[A179827], offering a …
Temazepam
Temazepam, like many other similar and related benzodiazepines, acts as a gamma-aminobutyric acid (GABA) modulator and is capable of eliciting a variety of actions including sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action [A175207, A175210, F3718, F3721].
Although the chemical synthesis of temazepam was established by 1965 ,...
Approved
Investigational
Matched Description: … Temazepam, like many other similar and related benzodiazepines, acts as a gamma-aminobutyric acid (GABA ... ) modulator and is capable of eliciting a variety of actions including sedation, hypnosis, skeletal muscle ... inherent nature of its pharmacological effects, temazepam - like many other benzodiazepines - possesses a …
Paricalcitol
Paricalcitol is a synthetic vitamin D analog. Paricalcitol has been used to reduce parathyroid hormone levels. Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure.
Approved
Investigational
Matched Description: … Paricalcitol is a synthetic vitamin D analog. …
Bordetella pertussis pertactin antigen
Bordetella pertussis pertactin antigen is a vaccine for the prophylaxis of whooping cough that contains pertactin, a membrane-associated antigen of Bordetella pertussis .
Approved
Investigational
Matched Description: … pertactin, a membrane-associated antigen of Bordetella pertussis [A31248]. ... Bordetella pertussis pertactin antigen is a vaccine for the prophylaxis of whooping cough that contains …
Quercus muehlenbergii pollen
Quercus muehlenbergii pollen allergenic extract is used in allergenic testing.
Approved
Cinacalcet
Cinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia and as Mimpara® in Europe. It is used to treat hyperparathyroidism due to parathyroid tumours or renal failure.
Approved
Matched Description: … Cinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia …
Plerixafor
Plerixafor is a small-molecule inhibitor of C-X-C chemokine receptor type 4 (CXCR4) that acts as a hematopoietic stem cell mobilizer.[A7117,L45678] It is used to stimulate the release of stem cells from the bone marrow into the blood in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma to stimulate their immune...
Approved
Investigational
Matched Description: … Plerixafor is a small-molecule inhibitor of C-X-C chemokine receptor type 4 (CXCR4) that acts as a hematopoietic ... [A7117] Compared to placebo with G-CSF, the plerixafor and G-CSF mobilization regimen has a higher probability …
Ospemifene
Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. FDA approved on February 26, 2013.
Approved
Investigational
Matched Description: … of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. ... Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment …
Sulfapyridine
Antibacterial, potentially toxic, and previously used to treat certain skin diseases. No longer prescribed.
Approved
Enfortumab vedotin
Enfortumab vedotin is an antibody-drug conjugate used in the treatment of patients with advanced, treatment-resistant urothelial cancers. It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protease-cleavable link. It is similar to brentuximab vedotin, another...
Approved
Investigational
Matched Description: … [L10836] It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting ... chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protease-cleavable link. ... The clinical development of enfortumab vedotin was the result of a collaboration between Astellas Pharma …
Pucotenlimab
Pucotenlimab is a recombinant humanized anti-PD-1 monoclonal antibody. It received its first global approval in China in July 2022 for the treatment of solid tumours. It is being investigated in other cancers.
Approved
Investigational
Matched Description: … Pucotenlimab is a recombinant humanized anti-PD-1 monoclonal antibody. …
Uridine triacetate
Uridine triacetate, formerly known as vistonuridine, is an orally active prodrug of the naturally occurring nucleoside uridine. It is used for the treatment of hereditary orotic aciduria (Xuriden), or for the emergency treatment of fluorouracil or capecitabine overdose or toxicity (Vistogard). It is provided in the prodrug form as uridine...
Approved
Investigational
Matched Description: … As a result of UMPS deficiency, patients experience a systemic deficiency of pyrimidine nucleotides, ... As a result, these metabolites are associated with various unpleasant side effects such as neutropenia ... It can also be used as a rescue therapy if severe side effects present within 96 hours after initiation …
Levobetaxolol
Levobetaxolol is a beta-blocker used to lower the pressure in the eye to treat conditions such as glaucoma. It was marketed as a 0.5% ophthalmic solution of levobetaxolol hydrochloride under the trade name Betaxon but has been discontinued.
Approved
Investigational
Matched Description: … Levobetaxolol is a beta-blocker used to lower the pressure in the eye to treat conditions such as glaucoma ... It was marketed as a 0.5% ophthalmic solution of levobetaxolol hydrochloride under the trade name Betaxon …
Ecallantide
Ecallantide is a potent and selective human plasma kallikrein inhibitor that is indicated for the symptomatic treatment of hereditary angioedema. Ecallantide is a recombinant 60-amino-acid protein produced in Pichia pastoris yeast cells that contains three intramolecular disulfide bonds [FDA Label]. It was discovered by phage display technology . It shares...
Approved
Investigational
Matched Description: … By reversibly binding to plasma kallikrein, ecallantide displays a rapid on-rate and a slow off-rate ... Ecallantide is a potent and selective human plasma kallikrein inhibitor that is indicated for the symptomatic ... Ecallantide is a recombinant 60-amino-acid protein produced in _Pichia pastoris_ yeast cells that contains …
Ubidecarenone
Ubidecarenone, also called coenzyme Q10, is a 1,4-benzoquinone. From its name (Q10), the Q refers to the constitutive quinone group, and 10 is related to the number of isoprenyl subunits in its tail. It is a powerful antioxidant, a lipid-soluble and essential cofactor in mitochondrial oxidative phosphorylation. The ubidecarenone is...
Approved
Investigational
Nutraceutical
Matched Description: … [A7874] It is a powerful antioxidant, a lipid-soluble and essential cofactor in mitochondrial oxidative ... [L1062] Ubidecarenone is sold as a dietary supplement and is not FDA approved as a drug - it is not meant ... Ubidecarenone, also called coenzyme Q10, is a 1,4-benzoquinone. …
Pegcetacoplan
Pegcetacoplan is a complement inhibitor indicated in the treatment of paroxysmal nocturnal hemoglobinuria (PNH).[A235000,L34095] Prior to its FDA approval, patients with PNH were typically treated with the C5 inhibiting monoclonal antibody eculizumab. Patients given eculizumab experienced less hemolysis caused by the membrane attack complex, but were still somewhat susceptible to...
Approved
Matched Description: … Pegcetacoplan is a complement inhibitor indicated in the treatment of paroxysmal nocturnal hemoglobinuria ... [A235000,A235005] Pegcetacoplan is a pegylated C3 inhibitor that can disrupt the processes leading to ... [A235000,A235005] Pegcetacoplan was developed out of a need for an inhibitor of complement mediated hemolysis …
Quaternium-15
Quaternium-15 is a quaternary ammonium salt used as a surfactant and preservative in many products including cosmetics. It is an anti-microbial agent by virtue of being a formaldehyde releaser, however this can also cause contact dermatitis, a symptom of an allergic reaction, especially in those with sensitive skin. In 2005,...
Approved
Experimental
Matched Description: … Quaternium-15 is a quaternary ammonium salt used as a surfactant and preservative in many products including ... Sensitivity to Quaternium-15 may be identified with a clinical patch test. ... contact dermatitis, a symptom of an allergic reaction, especially in those with sensitive skin. …
Cladribine
An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. Cladribine is also used to treat relapsing forms of multiple sclerosis.
Approved
Investigational
Oxcarbazepine
Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of carbamazepine and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exists as a racemate...
Approved
Matched Description: … [L8627,L8630,L8633] It is a structural derivative of [carbamazepine][A186101] and exerts a majority of ... its activity via a pharmacologically active metabolite, MHD, which exists as a racemate in the blood ... - a pro-drug of the more active (S)-enantiomer is also marketed as a separate anti-epileptic under the …
Displaying drugs 3601 - 3625 of 11300 in total