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Displaying drugs 401 - 425 of 13634 in total

Abaloparatide

Abaloparatide is an N-terminal analog of parathyroid hormone-related protein (PTHrP) and an agonist at the parathyroid hormone type 1 (PTH1) receptor. It is a synthetic 34 amino acid peptide with 41% homology to human parathyroid hormone 1-34 and human PTHrP 1-34. Abaloparatide and PTHrP share the first 21 amino acids...
Approved
Investigational
Matched Description: … [L740] In October 2022, the EMA's Committee for Medicinal Products for Human Use (CHMP) recommended abaloparatide ... [L740] It is a synthetic 34 amino acid peptide with 41% homology to human parathyroid hormone 1-34 and ... in postmenopausal women and is also used to increase bone density in men with osteoporosis. …

Trandolapril

Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure...
Approved
Matched Description: … Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor ... ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS ... clinically stable patients with left ventricular dysfunction, as an adjunct treatment for congestive …
Matched Categories: … Antihypertensive Agents Indicated for Hypertension …

Sarecycline

Sarecycline is a semi-synthetic derivative of tetracycline that was initially discovered by Paratek Pharmaceuticals from Boston, MA but then licensed to Warner Chilcott of Rockaway, NJ in July of 2007 . After completing various phase-II and phase-III trials demonstrating its effectiveness in treating moderate to severe facial acne vulgaris [A39993,...
Approved
Investigational
Matched Description: … low propensity for resistance development in such pathogens and a narrower, more specific spectrum of ... for the treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris in patients ... exist for treating acne vulgaris, sarecycline presents a new and innovative therapy choice because it …
Matched Categories: … Antibacterials for Systemic Use ... Antiinfectives for Systemic Use ... Anti-Acne Preparations for Systemic Use …

Vericiguat

Vericiguat is a direct stimulator of soluble guanylate cyclase (sGC) used in the management of systolic heart failure to reduce mortality and hospitalizations. A key component of the NO-sGC-cGMP signaling pathway that helps to regulate the cardiovascular system, sGC enzymes are intracellular enzymes found in vascular smooth muscle cells (amongst...
Approved
Investigational
Matched Description: … a relatively long half-life and allowing for once-daily dosing. ... [A227458] As a direct stimulator of sGC, vericiguat mitigates the need for a functional NO-sGC-cGMP axis ... Verquvo - for use in certain patients with systolic heart failure. …
Matched Categories: … Vasodilators Used in Cardiac Diseases …

Osimertinib

Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the T790M mutation as detected by FDA-approved testing...
Approved
Matched Description: … ATP binding activity to EGFR and result in poor prognosis for late-stage disease. ... ) in cases where tumour EGFR expression is positive for the T790M mutation as detected by FDA-approved ... In contrast, third-generation inhibitors are specific for the gate-keeper T790M mutations which increases …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Pramipexole

Pramipexole is a drug used to treat the symptoms of Parkinson's Disease (PD). It is a non-ergot dopamine agonist drug that is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement) . It was first approved by the FDA in 1997 . Parkinson's Disease is...
Approved
Investigational
Matched Description: … in 2006 for the treatment of Restless Legs Syndrome (RLS) [A176873]. ... In addition to the above FDA approval for Parkinson's Disease, pramipexole was also approved by the FDA ... It is a _non-ergot dopamine agonist_ drug that is efficacious in treating various Parkinson's symptoms …
Matched Products: … PRAMIPEXOLO SANDOZ A/S …

Cobimetinib

Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment of patients with unresectable or...
Approved
Investigational
Matched Description: … It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment of …
Matched Categories: … UGT2B7 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Baricitinib

Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated inflammation and immune responses. Baricitinib was...
Approved
Investigational
Matched Description: … [A248405] While baricitinib was granted emergency use as a treatment for COVID-19 in combination with ... JAK inhibitor used for this indication in Europe. ... Baricitinib is a Janus kinase (JAK) inhibitor. …
Matched Categories: … Experimental Unapproved Treatments for COVID-19 ... MATE 2 Substrates with a Narrow Therapeutic Index ... OAT3/SLC22A8 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Damoctocog alfa pegol

In recent years, various extended half-life factor VIII and factor IX preparations have been studied and gained approval. In order to extend half-lives, techniques such as fusion to protein conjugates (Fc part of IgG1 or albumin), chemical modification (PEGylation), and protein sequence modification have been utilized. Also known as, BAY94-9027,...
Approved
Investigational
Matched Description: … diagnosed with Haemophilia A. ... has been filed with the FDA in August 2017 and FDA approved in August 2018. ... [L4576,A38909,Label] This product has been engineered by Bayer[L4576] and a biological license application …

Clodronic acid

Clodronic acid is a first generation bisphosphonate similar to etidronic acid and tiludronic acid. These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. clodronate’s use has decreased over the years in favor of the third generation, nitrogen containing bisphosphonate zoledronic acid, ibandronic acid,...
Approved
Investigational
Vet approved
Matched Description: … [A203111] Clodronic acid is not FDA approved, but is approved in Canada.[L13910] ... Clodronic acid is a first generation bisphosphonate similar to [etidronic acid] and [tiludronic acid] ... [A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification …
Matched Categories: … Drugs for Treatment of Bone Diseases …

Coagulation factor VIIa Recombinant Human

Recombinant human coagulation Factor VIIa (rFVIIa), intended for promoting hemostasis by activating the extrinsic pathway of the coagulation cascade. NovoSeven is a vitamin K-dependent glycoprotein consisting of 406 amino acid residues. Cloned and expressed in hamster kidney cells, the protein is catalytically active in a two-chain form.
Approved
Matched Description: … Cloned and expressed in hamster kidney cells, the protein is catalytically active in a two-chain form ... Recombinant human coagulation Factor VIIa (rFVIIa), intended for promoting hemostasis by activating the ... NovoSeven is a vitamin K-dependent glycoprotein consisting of 406 amino acid residues. …
Matched Products: … powder and solvent for solution for injection 2mg ... powder and solvent for solution for injection 1mg ... NOVOSEVEN 2MG POWDER AND SOLVENT FOR SOLUTION FOR INJECTION …

Velaglucerase alfa

Velaglucerase alfa is a gene-activated human recombinant glucocerebrosidase used for the treatment of Type 1 Gaucher disease, caused by a deficiency of the lysosomal enzyme glucocerebrosidase. Additionally, Velaglucerase alfa has also been investigated for use in Type 3 Gaucher disease.
Approved
Investigational
Matched Description: … Additionally, Velaglucerase alfa has also been investigated for use in Type 3 Gaucher disease. ... Velaglucerase alfa is a gene-activated human recombinant glucocerebrosidase used for the treatment of ... Type 1 Gaucher disease, caused by a deficiency of the lysosomal enzyme glucocerebrosidase. …
Matched Products: … VPRIV POWDER FOR SOLUTION FOR INFUSION 400 UNITS/VIAL …

Technetium Tc-99m tetrofosmin

Technetium Tc-99m tetrofosmin is a drug used in nuclear myocardial perfusion imaging. The radioisotope, technetium-99m, is chelated by two 1,2-bis[di-(2-ethoxyethyl)phosphino]ethane ligands which belong to the group of diphosphines and which are referred to as tetrofosmin. It is a lipophilic technetium phosphine dioxo cation that was formulated into a freeze-dried kit...
Approved
Matched Description: … Technetium Tc-99m tetrofosmin is a drug used in nuclear myocardial perfusion imaging. ... It is a lipophilic technetium phosphine dioxo cation that was formulated into a freeze-dried kit which …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Magnesium acetate tetrahydrate

Magnesium acetate tetrahydrate is a hydrated form of anhydrous magnesium acetate salt with the chemical formula of Mg(CH3COO)2 • 4H2O. As a salt form of magnesium, magnesium acetate is one of the bioavailable forms of magnesium and forms a very water soluble compound. Magnesium is an essential element and second...
Approved
Matched Description: … Magnesium is an essential element and second most abundant cation in the body that plays a key role in ... Magnesium acetate tetrahydrate can be used as an electrolyte supplementation or a reagent in molecular ... a very water soluble compound. …
Matched Mixtures name: … NUTRIFLEX PERI IN 2000ML TWIN-FLEX ... NUTRIFLEX PLUS IN 1000ML TWIN FLEX ... NUTRIFLEX PLUS IN 2000ML TWIN FLEX …

Acebutolol

A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action.
Approved
Investigational
Matched Description: … A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. …
Matched Categories: … Antihypertensive Agents Indicated for Hypertension …

Deferasirox

Deferasirox is an iron chelator and the first oral medication FDA approved for chronic iron overload in patients receiving long term blood transfusions.
Approved
Investigational
Matched Description: … in patients receiving long term blood transfusions. ... Deferasirox is an iron chelator and the first oral medication FDA approved for chronic iron overload …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Fosdenopterin

Molybdenum cofactor deficiency (MoCD) is an exceptionally rare autosomal recessive disorder resulting in a deficiency of three molybdenum-dependent enzymes: sulfite oxidase (SOX), xanthine dehydrogenase, and aldehyde oxidase. Signs and symptoms begin shortly after birth and are caused by a build-up of toxic sulfites resulting from a lack of SOX activity.[A230088,L32163]...
Approved
Matched Description: … in patients with MoCD type A,[L32163] becoming the first and only therapy approved for the treatment ... the first therapeutic option for patients with MoCD type A. ... In July 2022, the EMA's Committee for Medicinal Products for Human Use (CHMP) recommended fosdenopterin …

Sevoflurane

Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 1996....
Approved
Vet approved
Matched Description: … [A249910] Therefore, it can be used for inhalational induction in adults and children for a wide variety ... [L42340] Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved ... [L42340] It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition …
Matched Products: … Sevolox Liquid for Inhalation, 100%v/v …

Niraparib

Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, fallopian tube, or...
Approved
Investigational
Matched Description: … By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. …
Matched Categories: … MATE 1 Substrates with a Narrow Therapeutic Index ... MATE 2 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index …

Calcium acetate

The chemical compound calcium acetate is the calcium salt of acetic acid. It has been commonly referred to as the acetate of lime. The anhydrous form is very hygroscopic, therefore the monohydrate is the common form.
Approved
Investigational
Matched Categories: … Compounds used in a research, industrial, or household setting ... Drugs for Treatment of Hyperkalemia and Hyperphosphatemia …

Conestat alfa

C1 Esterase Inhibitor (Recombinant) is a recombinant analogue of endogenous complement component-1 esterase inhibitor (rhC1INH), purified from the milk of transgenic rabbits. The primary function of endogenous C1INH is to regulate the activation of the complement and contact system pathways. It does this through inhibition of several target proteases within...
Approved
Investigational
Matched Description: … C1 Esterase Inhibitor (Recombinant) is a recombinant analogue of endogenous complement component-1 esterase ... Deficiency of C1-inhibitor allows for increased plasma kallikrein activation and subsequent production ... Marketed as the product Ruconest (FDA), this drug is indicated for the treatment of acute attacks of …
Matched Categories: … Drugs Used in Hereditary Angioedema …

Varicella zoster vaccine (live/attenuated)

Live attenuated zoster vaccine is available as two products: Zostavax for the prevention of shingles in immunocompetent people over the age of 50, and Varivax for the prevention of chickenpox in individuals 12 months of age and older. While the two vaccines contain the same immunological components and provide protection...
Approved
Matched Description: … in immunocompetent people over the age of 50, and Varivax for the prevention of chickenpox in individuals ... Risk factors for developing shingles include old age, with rates increasing substantially in person's ... Clinical trials for Shingrix have shown greater than 90% efficacy in adults aged 50 and older, with 89% …
Matched Mixtures name: … Priorix - Tetra Pulver in einer Durchstechflasche und Lösungsmittel in einer Fertigspritze zur Herstellung …
Matched Categories: … Antiinfectives for Systemic Use …
Matched Products: … VARIVAX Pulver und Lösungsmittel zur Herstellung einer Injektionssuspension in einer Fertigspritze ... Varilrix Pulver und Lösungsmittel zur Herstellung einer Injektionssuspension in einer Fertigspritze …

Etacrynic acid

A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop...
Approved
Investigational
Matched Description: … A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of ... This compound has been classified as a loop or high ceiling diuretic. ... in extracellular fluid. …
Matched Categories: … Medications that reduce magnesium levels …
Matched Products: … Ethacrynate Sodium for Injection ... Ethacrynate Sodium for Injection USP …

Methyldopa

Methyldopa, or α-methyldopa, is a centrally acting sympatholytic agent and an antihypertensive agent. It is an analog of DOPA (3,4‐hydroxyphenylanine), and it is a prodrug, meaning that the drug requires biotransformation to an active metabolite for therapeutic effects. Methyldopa works by binding to alpha(α)-2 adrenergic receptors as an agonist, leading...
Approved
Matched Description: … requires biotransformation to an active metabolite for therapeutic effects. ... Methyldopa, or α-methyldopa, is a centrally acting sympatholytic agent and an antihypertensive agent. ... [A231784] It is an analog of DOPA (3,4‐hydroxyphenylanine), and it is a prodrug, meaning that the drug …
Matched Categories: … Antihypertensive Agents Indicated for Hypertension …

Paroxetine

Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others. It was approved by the FDA in the early 1990s and marketed by SmithKline...
Approved
Investigational
Matched Description: … [L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition ... Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members ... [T653] It was approved by the FDA in the early 1990s and marketed by SmithKline Beecham. …
Matched Categories: … Antidepressive Agents Indicated for Depression …
Displaying drugs 401 - 425 of 13634 in total