Displaying drugs 51 - 75 of 590 in total
Butyl alcohol
Experimental
Matched Synonyms: … N-butyl alcohol …
Matched Name: … Butyl alcohol …
Matched Categories: … Alcohols ... Fatty Alcohols …
Matched Name: … Butyl alcohol …
Matched Categories: … Alcohols ... Fatty Alcohols …
Caprylic alcohol
Caprylic alcohol has been used in trials studying the treatment of Essential Tremor.
Investigational
Matched Name: … Caprylic alcohol …
Matched Description: … Caprylic alcohol has been used in trials studying the treatment of Essential Tremor. …
Matched Categories: … Alcohols ... Fatty Alcohols …
Matched Description: … Caprylic alcohol has been used in trials studying the treatment of Essential Tremor. …
Matched Categories: … Alcohols ... Fatty Alcohols …
Cinnamyl alcohol
Cinnamyl alcohol is a naturally occurring compound that is found within cinnamon. Due to the low levels found in cinnamon, cinnamyl alcohol is usually supplied as DB14184 within commercial products.
Cinnamyl alcohol has been shown to be a skin sensitizer, with a NOEL (No Effect Level) of ~4% . Sensitivity...
Approved
Experimental
Matched Synonyms: … Cinnamyl alcohol ... (E)-cinnamyl alcohol …
Matched Name: … Cinnamyl alcohol …
Matched Description: … Cinnamyl alcohol is a naturally occurring compound that is found within cinnamon. ... Sensitivity to cinnamyl alcohol may be identified with a clinical patch test. ... Cinnamyl alcohol has been shown to be a skin sensitizer, with a NOEL (No Effect Level) of ~4% [A34266 …
Matched Categories: … Alcohols …
Matched Name: … Cinnamyl alcohol …
Matched Description: … Cinnamyl alcohol is a naturally occurring compound that is found within cinnamon. ... Sensitivity to cinnamyl alcohol may be identified with a clinical patch test. ... Cinnamyl alcohol has been shown to be a skin sensitizer, with a NOEL (No Effect Level) of ~4% [A34266 …
Matched Categories: … Alcohols …
(R)-1-phenylethanol
Experimental
Matched Synonyms: … (R)-α-methylbenzyl alcohol ... (R)-alpha-methylbenzyl alcohol …
Vestronidase alfa
Vestronidase alfa, or vestronidase alfa-vjbk, is a recombinant human lysosomal beta glucuronidase that is a purified enzyme produced by recombinant DNA technology in a Chinese hamster ovary cell line. The enzyme is a homotetramer consisted of 4 monomers with 629 amino acids, and holds the same amino acid sequence as...
Approved
Investigational
Matched Synonyms: … Vestronidase alfa ... Vestronidase alfa-vjbk …
Matched Name: … Vestronidase alfa …
Matched Description: … In clinical trials, vestronidase alfa treatment demonstrated improvement and stabilization in motor symptoms ... Vestronidase alfa, or vestronidase alfa-vjbk, is a recombinant human lysosomal beta glucuronidase that ... spleen, heart valve abnormalities, and narrowed airways which can lead to lung infections and trouble …
Matched Categories: … vestronidase alfa ... Enzymes and Coenzymes ... Alimentary Tract and Metabolism …
Matched Name: … Vestronidase alfa …
Matched Description: … In clinical trials, vestronidase alfa treatment demonstrated improvement and stabilization in motor symptoms ... Vestronidase alfa, or vestronidase alfa-vjbk, is a recombinant human lysosomal beta glucuronidase that ... spleen, heart valve abnormalities, and narrowed airways which can lead to lung infections and trouble …
Matched Categories: … vestronidase alfa ... Enzymes and Coenzymes ... Alimentary Tract and Metabolism …
Vanillyl alcohol
Vanillyl alcohol has been used in trials studying the treatment of Smoking.
Investigational
Matched Name: … Vanillyl alcohol …
Matched Description: … Vanillyl alcohol has been used in trials studying the treatment of Smoking. …
Matched Categories: … Alcohols …
Matched Description: … Vanillyl alcohol has been used in trials studying the treatment of Smoking. …
Matched Categories: … Alcohols …
Drotrecogin alfa
Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated...
Approved
Investigational
Withdrawn
Matched Synonyms: … Drotrecogin-alfa ... Drotrecogin alfa activated ... Drotrecogin alfa (activated) …
Matched Name: … Drotrecogin alfa …
Matched Description: … It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and ... Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. ... Drotrecogin alfa was withdrawn from the market after a major study indicated that it was not effective …
Matched Categories: … drotrecogin alfa (activated) ... Enzymes and Coenzymes ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Matched Name: … Drotrecogin alfa …
Matched Description: … It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and ... Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. ... Drotrecogin alfa was withdrawn from the market after a major study indicated that it was not effective …
Matched Categories: … drotrecogin alfa (activated) ... Enzymes and Coenzymes ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Simoctocog alfa
Simoctocog alfa is a recombinant B-domain deleted (BDD) rFVIII produced in genetically modified human embryonic kidney (HEK) 293F cells. The harvested product is concentrated and purified by a series of chromatography steps. It is an antihemorrhagic agent used as a replacement therapy in individuals with Haemophilia A who lack the...
Approved
Matched Synonyms: … Simoctocog alfa …
Matched Name: … Simoctocog alfa …
Matched Description: … The harvested product is concentrated and purified by a series of chromatography steps. ... + A3-C1-C2 whereas the B-domain, present in the full-length plasma-derived FVIII, has been deleted and ... potentially immunogenic glycosylation patterns found in non-human cell lines led to decreased immunogenicity and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Name: … Simoctocog alfa …
Matched Description: … The harvested product is concentrated and purified by a series of chromatography steps. ... + A3-C1-C2 whereas the B-domain, present in the full-length plasma-derived FVIII, has been deleted and ... potentially immunogenic glycosylation patterns found in non-human cell lines led to decreased immunogenicity and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Rasdegafusp alfa
Rasdegafusp alfa is under investigation in clinical trial NCT03206047 (Atezolizumab, Guadecitabine, and CDX-1401 Vaccine in Treating Patients With Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer).
Investigational
Matched Synonyms: … Rasdegafusp alfa …
Matched Name: … Rasdegafusp alfa …
Matched Description: … Rasdegafusp alfa is under investigation in clinical trial NCT03206047 (Atezolizumab, Guadecitabine, and …
Matched Name: … Rasdegafusp alfa …
Matched Description: … Rasdegafusp alfa is under investigation in clinical trial NCT03206047 (Atezolizumab, Guadecitabine, and …
Efgartigimod alfa
Myasthenia gravis (MG) is an autoimmune disorder characterized by significant muscle weakness - particularly in the eye, throat, and extremities - caused by autoantibodies attacking the neuromuscular junction. The production of IgG autoantibodies against acetylcholine receptors (AChRs) is one of the more common pathophysiological mechanisms behind MG, and results in...
Approved
Investigational
Matched Synonyms: … Efgartigimod alfa …
Matched Name: … Efgartigimod alfa …
Matched Description: … Efgartigimod alfa for intravenous use was granted FDA approval on December 17, 2021[L39501] and European ... [L43190] A formulation for subcutaneous use that combines efgartigimod alfa and hyaluronidase was approved ... [L39509] By antagonizing this interaction, efgartigimod alfa prevents this recycling phase and thus decreases …
Matched Categories: … efgartigimod alfa ... Antineoplastic and Immunomodulating Agents …
Matched Name: … Efgartigimod alfa …
Matched Description: … Efgartigimod alfa for intravenous use was granted FDA approval on December 17, 2021[L39501] and European ... [L43190] A formulation for subcutaneous use that combines efgartigimod alfa and hyaluronidase was approved ... [L39509] By antagonizing this interaction, efgartigimod alfa prevents this recycling phase and thus decreases …
Matched Categories: … efgartigimod alfa ... Antineoplastic and Immunomodulating Agents …
Bintrafusp alfa
Bintrafusp alfa is under investigation in clinical trial NCT03833661 (M7824 Monotherapy in Locally Advanced or Metastatic Second Line (2L) Biliary Tract Cancer (Cholangiocarcinoma and Gallbladder Cancer)).
Investigational
Matched Synonyms: … Bintrafusp alfa …
Matched Name: … Bintrafusp alfa …
Matched Description: … or Metastatic Second Line (2L) Biliary Tract Cancer (Cholangiocarcinoma and Gallbladder Cancer)). ... Bintrafusp alfa is under investigation in clinical trial NCT03833661 (M7824 Monotherapy in Locally Advanced …
Matched Name: … Bintrafusp alfa …
Matched Description: … or Metastatic Second Line (2L) Biliary Tract Cancer (Cholangiocarcinoma and Gallbladder Cancer)). ... Bintrafusp alfa is under investigation in clinical trial NCT03833661 (M7824 Monotherapy in Locally Advanced …
Efizonerimod alfa
Efizonerimod alfa is under investigation in clinical trial NCT02221960 (A Phase 1 Study to Evaluate MEDI6383 Alone and in Combination With MEDI4736 in Adult Subjects With Select Advanced Solid Tumors).
Investigational
Matched Synonyms: … Efizonerimod alfa …
Matched Name: … Efizonerimod alfa …
Matched Description: … Alone and in Combination With MEDI4736 in Adult Subjects With Select Advanced Solid Tumors). ... Efizonerimod alfa is under investigation in clinical trial NCT02221960 (A Phase 1 Study to Evaluate MEDI6383 …
Matched Name: … Efizonerimod alfa …
Matched Description: … Alone and in Combination With MEDI4736 in Adult Subjects With Select Advanced Solid Tumors). ... Efizonerimod alfa is under investigation in clinical trial NCT02221960 (A Phase 1 Study to Evaluate MEDI6383 …
Omidenepag isopropyl
Omidenepag isopropyl is a topical ocular hypotensive agent used to reduce intraocular pressure (IOP) in patients with glaucoma and ocular hypertension. Omidenepag isopropyl is quickly metabolized to its active metabolite, omidenepag, a molecule with high selectivity and agonistic activity towards the prostaglandin E2 (EP2) receptor.[A253263,A253268] Prostanoid FP receptor agonists (FP...
Approved
Investigational
Matched Synonyms: … Omidenepag isopropyl ... isopropyl N-(6-(((4-(1H-pyrazol-1-yl)benzyl)(3-pyridinylsulfonyl)amino)methyl)-2-pyridinyl)glycinate …
Matched Name: … Omidenepag isopropyl …
Matched Description: … [A253253] In 2018, omidenepag isopropyl was approved in Japan for the treatment of glaucoma and ocular ... in patients with glaucoma and ocular hypertension. ... [A253268] In September 2022, the FDA approved the use of omidenepag isopropyl.[L43503] …
Matched Name: … Omidenepag isopropyl …
Matched Description: … [A253253] In 2018, omidenepag isopropyl was approved in Japan for the treatment of glaucoma and ocular ... in patients with glaucoma and ocular hypertension. ... [A253268] In September 2022, the FDA approved the use of omidenepag isopropyl.[L43503] …
Trenonacog alfa
Human coagulation factor IX (EC 3.4.21.22, Christmas factor, plasma thromboplastin component), produced in CHO cells.
Investigational
Matched Synonyms: … Trenonacog alfa …
Matched Name: … Trenonacog alfa …
Matched Categories: … Enzymes and Coenzymes ... Amino Acids, Peptides, and Proteins …
Matched Name: … Trenonacog alfa …
Matched Categories: … Enzymes and Coenzymes ... Amino Acids, Peptides, and Proteins …
Tadekinig alfa
Tadekinig alfa is under investigation in clinical trial NCT03113760 (Therapeutic Use of Tadekinig Alfa in NLRC4 Mutation and XIAP Deficiency).
Investigational
Matched Synonyms: … Tadekinig alfa …
Matched Name: … Tadekinig alfa …
Matched Description: … in NLRC4 Mutation and XIAP Deficiency). ... Tadekinig alfa is under investigation in clinical trial NCT03113760 (Therapeutic Use of Tadekinig Alfa …
Matched Name: … Tadekinig alfa …
Matched Description: … in NLRC4 Mutation and XIAP Deficiency). ... Tadekinig alfa is under investigation in clinical trial NCT03113760 (Therapeutic Use of Tadekinig Alfa …
Pegunigalsidase alfa
Pegunigalsidase alfa (PRX-102) is a recombinant form of human α-galactosidase-A indicated for long-term enzyme replacement therapy in patients with Fabry disease, a rare genetic disorder characterized by the deficiency of alpha-galactosidase A.[A259352,L46342] Unlike other forms of recombinant alpha-galactosidase A, such as agalsidase alfa and agalsidase beta, pegunigalsidase alfa uses a...
Approved
Investigational
Matched Synonyms: … Pegunigalsidase alfa …
Matched Name: … Pegunigalsidase alfa …
Matched Description: … [A259352,L46342] Unlike other forms of recombinant alpha-galactosidase A, such as [agalsidase alfa] and ... While agalsidase alfa and agalsidase beta enter lysosomes via the mannose-6-phosphate (M6P) receptor, ... Furthermore, the pegylation of pegunigalsidase alfa promotes higher stability and a longer half-life, …
Matched Categories: … pegunigalsidase alfa ... Enzymes and Coenzymes ... Alimentary Tract and Metabolism …
Matched Name: … Pegunigalsidase alfa …
Matched Description: … [A259352,L46342] Unlike other forms of recombinant alpha-galactosidase A, such as [agalsidase alfa] and ... While agalsidase alfa and agalsidase beta enter lysosomes via the mannose-6-phosphate (M6P) receptor, ... Furthermore, the pegylation of pegunigalsidase alfa promotes higher stability and a longer half-life, …
Matched Categories: … pegunigalsidase alfa ... Enzymes and Coenzymes ... Alimentary Tract and Metabolism …
Asfotase alfa
Asfotase alfa is a first-in-class bone-targeted enzyme replacement therapy designed to address the underlying cause of hypophosphatasia (HPP)—deficient alkaline phosphatase (ALP). Hypophosphatasia is almost always fatal when severe skeletal disease is obvious at birth. By replacing deficient ALP, treatment with Asfotase Alfa aims to improve the elevated enzyme substrate levels...
Approved
Investigational
Matched Synonyms: … Asfotase alfa …
Matched Name: … Asfotase alfa …
Matched Description: … Asfotase alfa was first approved by Pharmaceuticals and Medicals Devices Agency of Japan (PMDA) on July ... levels and improve the body's ability to mineralize bone, thereby preventing serious skeletal and systemic ... patient morbidity and premature death. …
Matched Categories: … asfotase alfa ... Enzymes and Coenzymes ... Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins …
Matched Name: … Asfotase alfa …
Matched Description: … Asfotase alfa was first approved by Pharmaceuticals and Medicals Devices Agency of Japan (PMDA) on July ... levels and improve the body's ability to mineralize bone, thereby preventing serious skeletal and systemic ... patient morbidity and premature death. …
Matched Categories: … asfotase alfa ... Enzymes and Coenzymes ... Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins …
Turoctocog alfa
Turoctocog alfa is a recombinant factor VIII (rFVIII) with a truncated B-domain made from the sequence coding for 10 amino acids from the N-terminus and 11 amino acids from the C-terminus of the naturally occurring B-domain. Turoctocog alfa is produced in Chinese hamster ovary (CHO) cells without addition of any...
Approved
Investigational
Matched Synonyms: … Turoctocog alfa …
Matched Name: … Turoctocog alfa …
Matched Description: … Turoctocog alfa is a recombinant factor VIII (rFVIII) with a truncated B-domain made from the sequence ... Turoctocog alfa is produced in Chinese hamster ovary (CHO) cells without addition of any human- or animal-derived ... [A31504] It was developped by Novo Nordisk and FDA approved in October 16, 2013.[L1104] …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … NovoEight 500IU Powder and Solvent for Solution for Injection ... NovoEight 1000IU Powder and Solvent for Solution for Injection ... NovoEight® 250IU Powder and Solvent for Solution for Injection …
Matched Name: … Turoctocog alfa …
Matched Description: … Turoctocog alfa is a recombinant factor VIII (rFVIII) with a truncated B-domain made from the sequence ... Turoctocog alfa is produced in Chinese hamster ovary (CHO) cells without addition of any human- or animal-derived ... [A31504] It was developped by Novo Nordisk and FDA approved in October 16, 2013.[L1104] …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … NovoEight 500IU Powder and Solvent for Solution for Injection ... NovoEight 1000IU Powder and Solvent for Solution for Injection ... NovoEight® 250IU Powder and Solvent for Solution for Injection …
Olipudase alfa
Olipudase alfa is recombinant human acid sphingomyelinase. It is the first and only enzyme replacement therapy in the world for the treatment of Acid Sphingomyelinase Deficiency (ASMD), also known as Niemann–Pick disease. ASMD is a rare lysosomal storage disease caused by mutations in the SMPD1 gene, leading to a deficiency...
Approved
Investigational
Matched Synonyms: … Olipudase alfa …
Matched Name: … Olipudase alfa …
Matched Description: … Olipudase alfa is recombinant human acid sphingomyelinase. ... , liver, spleen, kidneys, and bone marrow. ... [A251590] Olipudase alfa gained its first global approval in Japan on March 28, 2022. …
Matched Categories: … olipudase alfa ... Enzymes and Coenzymes ... Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins …
Matched Name: … Olipudase alfa …
Matched Description: … Olipudase alfa is recombinant human acid sphingomyelinase. ... , liver, spleen, kidneys, and bone marrow. ... [A251590] Olipudase alfa gained its first global approval in Japan on March 28, 2022. …
Matched Categories: … olipudase alfa ... Enzymes and Coenzymes ... Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins …
Valanafusp alfa
Valanafusp alfa is under investigation in clinical trial NCT03071341 (Extension Study Evaluating Long Term Safety and Activity of AGT-181 in Children With MPS I).
Investigational
Matched Synonyms: … Valanafusp alfa …
Matched Name: … Valanafusp alfa …
Matched Description: … Term Safety and Activity of AGT-181 in Children With MPS I). ... Valanafusp alfa is under investigation in clinical trial NCT03071341 (Extension Study Evaluating Long …
Matched Categories: … Enzymes and Coenzymes ... Amino Acids, Peptides, and Proteins …
Matched Name: … Valanafusp alfa …
Matched Description: … Term Safety and Activity of AGT-181 in Children With MPS I). ... Valanafusp alfa is under investigation in clinical trial NCT03071341 (Extension Study Evaluating Long …
Matched Categories: … Enzymes and Coenzymes ... Amino Acids, Peptides, and Proteins …
Vensobafusp alfa
Experimental
Matched Synonyms: … Vensobafusp alfa …
Matched Name: … Vensobafusp alfa …
Matched Name: … Vensobafusp alfa …
Lonoctocog alfa
Approved
Investigational
Matched Synonyms: … Lonoctocog alfa …
Matched Name: … Lonoctocog alfa …
Matched Products: … AFSTYLA POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 250IU/VIAL ... AFSTYLA 250IU powder and solvent for solution for injection ... AFSTYLA 500IU powder and solvent for solution for injection …
Matched Name: … Lonoctocog alfa …
Matched Products: … AFSTYLA POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 250IU/VIAL ... AFSTYLA 250IU powder and solvent for solution for injection ... AFSTYLA 500IU powder and solvent for solution for injection …
Displaying drugs 51 - 75 of 590 in total