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Displaying drugs 4751 - 4775 of 6340 in total
Latrunculin A
Latrunculin A is an actin binding macrolide purified from the red sea sponge Latrunculia magnifica. It is under investigation for the treatment of cancer. It disrupts actin polymerization, prevents mitotic spindle formation and thus cell replication.
Experimental
Forasartan
Forasartan, a specific angiotensin II antagonist, is used alone or with other antihypertensive agents to treat hypertension. Forasartan competes with angiotensin II for binding at the AT1 receptor subtype. As angiotensin II is a vasoconstrictor which also stimulates the synthesis and release of aldosterone, blockage of its effects results in...
Experimental
Matched Iupac: … 5-[(3,5-dibutyl-1H-1,2,4-triazol-1-yl)methyl]-2-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]pyridine …
Acadesine
Acadesine (AICA-riboside) is a purine nucleoside analog with anti-ischemic properties that is currently being studied (Phase 3) for the prevention of adverse cardiovascular outcomes in patients undergoing coronary artery bypass graft (CABG) surgery. It is being developed jointly by PeriCor and Schering-Plough. Acadesine has been granted Orphan Drug Designation for...
Investigational
Matched Iupac: … 5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-imidazole-4-carboxamide …
Rabusertib
Rabusertib has been used in trials studying the treatment of Cancer, Solid Tumors, Advanced Cancer, Pancreatic Neoplasms, and Non Small Cell Lung Cancer.
Investigational
Matched Iupac: … 3-(5-bromo-4-methyl-2-{[(2S)-morpholin-2-yl]methoxy}phenyl)-1-(5-methylpyrazin-2-yl)urea …
Pyritinol
Pyritinol has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders.
Investigational
Matched Iupac: … 5-[({[5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl]methyl}disulfanyl)methyl]-4-(hydroxymethyl)-2- …
Nifurzide
Experimental
Matched Iupac: … 5-nitro-N'-[(1E,2E)-3-(5-nitrofuran-2-yl)prop-2-en-1-ylidene]thiophene-2-carbohydrazide …
4-(Acetylamino)-3-[(Aminoacetyl)Amino]Benzoic Acid
Experimental
Matched Iupac: … [(5-carboxy-2-acetamidophenyl)carbamoyl]methanaminium …
Tretazicar
Tretazicar is under investigation in clinical trial NCT00746590 (Study of Anti-tumour Effects and Safety of Prolarix™ in Hepatocellular Carcinoma).
Investigational
Matched Iupac: … 5-(aziridin-1-yl)-2,4-dinitrobenzamide …
Cimlanod
Cimlanod is under investigation in clinical trial NCT02819271 (A First-in-Human Study of the Safety of Single Continuous Intravenous (IV) Infusions of CXL-1427 for up to 48 Hours in Healthy Volunteers).
Investigational
Matched Iupac: … N-hydroxy-5-methylfuran-2-sulfonamide …
Farampator
Farampator is under investigation in clinical trial NCT00113022 (Org 24448 to Treat Major Depression).
Investigational
Matched Iupac: … 5-(piperidine-1-carbonyl)-2,1,3-benzoxadiazole …
Clomethiazole
Clomethiazole is a well-established γ-aminobutyric acid (GABAA)-mimetic drug. It is a sedative and hypnotic that is widely used in treating and preventing symptoms of acute alcohol withdrawal. It is a drug which is structurally related to thiamine (vitamin B1) but acts like a sedative, hypnotic, muscle relaxant and anticonvulsant. It...
Investigational
Matched Iupac: … 5-(2-chloroethyl)-4-methyl-1,3-thiazole …
Iodamide
Iodamide is a contrast medium molecule that is no longer marketed in the United States.
Withdrawn
Matched Iupac: … 3-acetamido-5-(acetamidomethyl)-2,4,6-triiodobenzoic acid …
Tetrasul
Tetrasul has been used in trials studying the treatment of Erythematous (Type One) Rosacea.
Investigational
Matched Iupac: … 1,2,4-trichloro-5-[(4-chlorophenyl)sulfanyl]benzene …
PD-0299685
PD-0299685 is under investigation in clinical trial NCT00314964 (Study Evaluating PD-0299685 for the Treatment of Vasomotor Symptoms (Hot Flashes / Flushes) Associated With Menopause).
Investigational
Matched Iupac: … (3S,5R)-3-(aminomethyl)-5-methyloctanoic acid …
SNS-032
Investigational
Matched Iupac: … N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide …
Polaprezinc
Polaprezinc is a chelated form of zinc and L-carnosine. It is a zinc-related medicine approved for the first time in Japan, which has been clinically used to treat gastric ulcers [L1307, L1308]. It was determined that polaprezinc may be effective in pressure ulcer treatment . A study in 2013 showed...
Experimental
Matched Iupac: … (4S)-3-(3-aminopropanoyl)-4-[(1H-imidazol-5-yl)methyl]-1-oxa-3-aza-2-zincacyclopentan-5-one …
Latrepirdine
Latrepirdine has been investigated for the treatment of Alzheimer's Disease and Huntington's Disease.
Investigational
Matched Iupac: … 5-(2-{2,8-dimethyl-1H,2H,3H,4H,5H-pyrido[4,3-b]indol-5-yl}ethyl)-2-methylpyridine …
Filorexant
Filorexant has been used in trials studying the prevention and treatment of Migraine, Headache, Polysomnography, Diabetic Neuropathy, Painful, and Major Depressive Disorder, Recurrent.
Investigational
Matched Iupac: … 2-{2-[(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidine-1-carbonyl]-4-methylphenyl}pyrimidine …
Mizoribine
Mizoribine has been investigated for the treatment of Rheumatoid Arthritis.
Investigational
Matched Iupac: … 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxy-1H-imidazole-4-carboxamide …
GSK-1292263
GSK1292263 has been investigated for the treatment of DIABETES MELLITUS, TYPE 2.
Investigational
Matched Iupac: … 2-(4-methanesulfonylphenyl)-5-({1-[3-(propan-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-4-yl}methoxy)pyridine …
Darglitazone
Experimental
Matched Iupac: … 5-({4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propanoyl]phenyl}methyl)-1,3-thiazolidine-2,4-dione …
Displaying drugs 4751 - 4775 of 6340 in total