This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
clomethiazole
Accession Number
DB06470
Type
Small Molecule
Groups
Investigational
Description

Clomethiazole is a well-established γ-aminobutyric acid (GABAA)-mimetic drug. It is a sedative and hypnotic that is widely used in treating and preventing symptoms of acute alcohol withdrawal. It is a drug which is structurally related to thiamine (vitamin B1) but acts like a sedative, hypnotic, muscle relaxant and anticonvulsant. It is also used for the management of agitation, restlessness, short-term insomnia and Parkinson's disease in the elderly.

Structure
Thumb
Synonyms
Not Available
Product Ingredients
IngredientUNIICASInChI Key
Clomethiazole Hydrochloride85223EMG446001-74-7OFXYKSLKNMTBHK-UHFFFAOYSA-N
International/Other Brands
Zendra
Categories
UNII
0C5DBZ19HV
CAS number
Not Available
Weight
Average: 161.65
Monoisotopic: 161.0065981
Chemical Formula
C6H8ClNS
InChI Key
PCLITLDOTJTVDJ-UHFFFAOYSA-N
InChI
InChI=1S/C6H8ClNS/c1-5-6(2-3-7)9-4-8-5/h4H,2-3H2,1H3
IUPAC Name
5-(2-chloroethyl)-4-methyl-1,3-thiazole
SMILES
CC1=C(CCCl)SC=N1

Pharmacology

Indication

Investigated for use/treatment in strokes.

Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action

clomethiazole interacts with the GABAA receptor complex. It inhibits the binding of [35S]butyl-bicyclophosphorothionate (TBPS), an effect indicative of GABAA receptor-channel activation, by increasing the rate of [35S]TBPS dissociation and decreasing the binding affinity. Gamma-aminobutyric acid (GABA), acting at GABAA receptors, is the main fast inhibitory neurotransmitter in mammalian central nervous system

TargetActionsOrganism
UGamma-aminobutyric acid receptor subunit alpha-1Not AvailableHuman
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with clomethiazole.Experimental
AbirateroneThe metabolism of clomethiazole can be decreased when combined with Abiraterone.Approved
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with clomethiazole.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with clomethiazole.Approved
AdipiplonThe risk or severity of adverse effects can be increased when clomethiazole is combined with Adipiplon.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Agomelatine.Approved, Investigational
AlaproclateThe risk or severity of adverse effects can be increased when clomethiazole is combined with Alaproclate.Experimental
AlfaxaloneThe risk or severity of adverse effects can be increased when clomethiazole is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with clomethiazole.Approved, Illicit
AllopregnanoloneThe risk or severity of adverse effects can be increased when clomethiazole is combined with Allopregnanolone.Investigational
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with clomethiazole.Experimental, Illicit
AlphaprodineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Alphaprodine.Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with clomethiazole.Approved, Illicit, Investigational
AmiodaroneThe metabolism of clomethiazole can be decreased when combined with Amiodarone.Approved, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Amisulpride is combined with clomethiazole.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Amitriptyline.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with clomethiazole.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Amoxapine.Approved
AmperozideThe risk or severity of adverse effects can be increased when clomethiazole is combined with Amperozide.Experimental
AprepitantThe serum concentration of clomethiazole can be increased when it is combined with Aprepitant.Approved, Investigational
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with clomethiazole.Approved, Investigational
ArmodafinilThe metabolism of clomethiazole can be decreased when combined with Armodafinil.Approved, Investigational
ArticaineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Articaine.Approved
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with clomethiazole.Approved
AtazanavirThe metabolism of clomethiazole can be decreased when combined with Atazanavir.Approved, Investigational
AtomoxetineThe metabolism of clomethiazole can be decreased when combined with Atomoxetine.Approved
AzaperoneThe risk or severity of adverse effects can be increased when clomethiazole is combined with Azaperone.Investigational, Vet Approved
Azelastineclomethiazole may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
BaclofenThe risk or severity of adverse effects can be increased when clomethiazole is combined with Baclofen.Approved
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with clomethiazole.Illicit
BenperidolThe risk or severity of adverse effects can be increased when clomethiazole is combined with Benperidol.Investigational
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with clomethiazole.Approved
Benzyl alcoholThe risk or severity of adverse effects can be increased when clomethiazole is combined with Benzyl alcohol.Approved
BoceprevirThe metabolism of clomethiazole can be decreased when combined with Boceprevir.Approved, Withdrawn
BortezomibThe metabolism of clomethiazole can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of clomethiazole can be decreased when it is combined with Bosentan.Approved, Investigational
BrexpiprazoleThe risk or severity of adverse effects can be increased when clomethiazole is combined with Brexpiprazole.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of clomethiazole.Approved
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with clomethiazole.Approved, Illicit
BromisovalThe risk or severity of adverse effects can be increased when clomethiazole is combined with Bromisoval.Experimental
BromperidolThe risk or severity of adverse effects can be increased when clomethiazole is combined with Bromperidol.Investigational
BrompheniramineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when clomethiazole is combined with Brotizolam.Approved, Investigational, Withdrawn
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with clomethiazole.Approved, Investigational
Buprenorphineclomethiazole may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with clomethiazole.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with clomethiazole.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Butacaine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when clomethiazole is combined with Butalbital.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when clomethiazole is combined with Butamben.Approved
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with clomethiazole.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with clomethiazole.Approved, Illicit, Vet Approved
CanertinibThe risk or severity of adverse effects can be increased when Canertinib is combined with clomethiazole.Investigational
CarbamazepineThe metabolism of clomethiazole can be increased when combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Carbinoxamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with clomethiazole.Illicit, Investigational, Vet Approved
CarisoprodolThe risk or severity of adverse effects can be increased when clomethiazole is combined with Carisoprodol.Approved
CeritinibThe serum concentration of clomethiazole can be increased when it is combined with Ceritinib.Approved
CetirizineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Cetirizine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with clomethiazole.Approved, Illicit, Vet Approved
ChloramphenicolThe metabolism of clomethiazole can be decreased when combined with Chloramphenicol.Approved, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with clomethiazole.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with clomethiazole.Approved, Investigational, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with clomethiazole.Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Chlorphenamine.Approved
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with clomethiazole.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with clomethiazole.Approved, Investigational, Withdrawn
ChlorzoxazoneThe risk or severity of adverse effects can be increased when clomethiazole is combined with Chlorzoxazone.Approved
CholecalciferolThe metabolism of clomethiazole can be decreased when combined with Cholecalciferol.Approved, Nutraceutical
CimetidineThe metabolism of clomethiazole can be decreased when combined with Cimetidine.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with clomethiazole.Approved, Vet Approved
CitalopramThe metabolism of clomethiazole can be decreased when combined with Citalopram.Approved
ClarithromycinThe metabolism of clomethiazole can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of clomethiazole can be decreased when combined with Clemastine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when clomethiazole is combined with Clidinium.Approved
ClobazamThe risk or severity of adverse effects can be increased when clomethiazole is combined with Clobazam.Approved, Illicit
ClomipramineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when clomethiazole is combined with Clonazepam.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Clonidine.Approved
ClopenthixolThe risk or severity of adverse effects can be increased when clomethiazole is combined with Clopenthixol.Experimental
ClopidogrelThe metabolism of clomethiazole can be decreased when combined with Clopidogrel.Approved, Nutraceutical
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with clomethiazole.Approved, Illicit
ClothiapineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Clothiapine.Experimental
ClotrimazoleThe metabolism of clomethiazole can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with clomethiazole.Approved
CobicistatThe metabolism of clomethiazole can be decreased when combined with Cobicistat.Approved
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with clomethiazole.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with clomethiazole.Approved, Illicit
ConivaptanThe serum concentration of clomethiazole can be increased when it is combined with Conivaptan.Approved, Investigational
CrizotinibThe metabolism of clomethiazole can be decreased when combined with Crizotinib.Approved
CyclizineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with clomethiazole.Approved
CyclosporineThe metabolism of clomethiazole can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
CyproheptadineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Cyproheptadine.Approved
DabrafenibThe serum concentration of clomethiazole can be decreased when it is combined with Dabrafenib.Approved
DantroleneThe risk or severity of adverse effects can be increased when clomethiazole is combined with Dantrolene.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with clomethiazole.Approved
DapoxetineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Dapoxetine.Investigational
DarunavirThe metabolism of clomethiazole can be decreased when combined with Darunavir.Approved
DasatinibThe serum concentration of clomethiazole can be increased when it is combined with Dasatinib.Approved, Investigational
DeferasiroxThe serum concentration of clomethiazole can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of clomethiazole can be decreased when combined with Delavirdine.Approved
DeramciclaneThe risk or severity of adverse effects can be increased when clomethiazole is combined with Deramciclane.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with clomethiazole.Approved
DesipramineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Desipramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Detomidine.Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Dexbrompheniramine.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with clomethiazole.Approved, Vet Approved
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with clomethiazole.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with clomethiazole.Approved, Illicit, Investigational, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with clomethiazole.Approved, Investigational
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with clomethiazole.Approved, Illicit, Vet Approved
Diethyl etherThe risk or severity of adverse effects can be increased when clomethiazole is combined with Diethyl ether.Experimental
DifenoxinThe risk or severity of adverse effects can be increased when clomethiazole is combined with Difenoxin.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with clomethiazole.Approved, Illicit
DihydroergotamineThe metabolism of clomethiazole can be decreased when combined with Dihydroergotamine.Approved
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with clomethiazole.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with clomethiazole.Experimental, Illicit
DiltiazemThe metabolism of clomethiazole can be decreased when combined with Diltiazem.Approved
DimenhydrinateThe risk or severity of adverse effects can be increased when clomethiazole is combined with Dimenhydrinate.Approved
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with clomethiazole.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with clomethiazole.Approved, Illicit
DixyrazineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Dixyrazine.Experimental
DoramectinThe risk or severity of adverse effects can be increased when clomethiazole is combined with Doramectin.Vet Approved
DoxepinThe risk or severity of adverse effects can be increased when clomethiazole is combined with Doxepin.Approved
DoxorubicinThe metabolism of clomethiazole can be decreased when combined with Doxorubicin.Approved, Investigational
DoxycyclineThe metabolism of clomethiazole can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of clomethiazole.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when clomethiazole is combined with DPDPE.Experimental
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of clomethiazole.Approved, Illicit
DronedaroneThe metabolism of clomethiazole can be decreased when combined with Dronedarone.Approved
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of clomethiazole.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with clomethiazole.Experimental, Illicit
DuloxetineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with clomethiazole.Approved
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with clomethiazole.Experimental, Illicit
EcopipamThe risk or severity of adverse effects can be increased when clomethiazole is combined with Ecopipam.Investigational
EfavirenzThe risk or severity of adverse effects can be increased when clomethiazole is combined with Efavirenz.Approved, Investigational
EltanoloneThe risk or severity of adverse effects can be increased when clomethiazole is combined with Eltanolone.Investigational
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with clomethiazole.Approved, Investigational, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when clomethiazole is combined with Entacapone.Approved, Investigational
EnzalutamideThe serum concentration of clomethiazole can be decreased when it is combined with Enzalutamide.Approved
ErythromycinThe metabolism of clomethiazole can be decreased when combined with Erythromycin.Approved, Vet Approved
EscitalopramThe risk or severity of adverse effects can be increased when clomethiazole is combined with Escitalopram.Approved, Investigational
Eslicarbazepine acetateThe metabolism of clomethiazole can be decreased when combined with Eslicarbazepine acetate.Approved
EsomeprazoleThe metabolism of clomethiazole can be decreased when combined with Esomeprazole.Approved, Investigational
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with clomethiazole.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with clomethiazole.Approved
Ethanolclomethiazole may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with clomethiazole.Approved, Illicit, Withdrawn
EthosuximideThe risk or severity of adverse effects can be increased when clomethiazole is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when clomethiazole is combined with Ethotoin.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with clomethiazole.Withdrawn
Ethyl chlorideThe risk or severity of adverse effects can be increased when clomethiazole is combined with Ethyl chloride.Experimental, Investigational
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with clomethiazole.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with clomethiazole.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Etidocaine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Etifoxine.Investigational, Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when clomethiazole is combined with Etizolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with clomethiazole.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when clomethiazole is combined with Etoperidone.Withdrawn
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with clomethiazole.Illicit, Vet Approved
EtravirineThe metabolism of clomethiazole can be decreased when combined with Etravirine.Approved
EzogabineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when clomethiazole is combined with Felbamate.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with clomethiazole.Approved, Illicit, Withdrawn
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with clomethiazole.Approved, Illicit, Investigational, Vet Approved
FexofenadineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Fexofenadine.Approved
FlibanserinThe risk or severity of adverse effects can be increased when clomethiazole is combined with Flibanserin.Approved
FluanisoneThe risk or severity of adverse effects can be increased when clomethiazole is combined with Fluanisone.Experimental
FluconazoleThe metabolism of clomethiazole can be decreased when combined with Fluconazole.Approved
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with clomethiazole.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with clomethiazole.Approved, Illicit
FluoxetineThe metabolism of clomethiazole can be decreased when combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with clomethiazole.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with clomethiazole.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with clomethiazole.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Fluspirilene is combined with clomethiazole.Approved, Investigational
Fluticasone propionateThe risk or severity of adverse effects can be increased when clomethiazole is combined with Fluticasone propionate.Approved
FluvoxamineThe metabolism of clomethiazole can be decreased when combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe metabolism of clomethiazole can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of clomethiazole can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe metabolism of clomethiazole can be increased when combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when clomethiazole is combined with Fospropofol.Approved, Illicit, Investigational
Fusidic AcidThe serum concentration of clomethiazole can be increased when it is combined with Fusidic Acid.Approved
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with clomethiazole.Approved, Investigational
Gabapentin EnacarbilThe risk or severity of adverse effects can be increased when clomethiazole is combined with Gabapentin Enacarbil.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with clomethiazole.Approved, Illicit, Investigational
GemfibrozilThe metabolism of clomethiazole can be decreased when combined with Gemfibrozil.Approved
GepironeThe risk or severity of adverse effects can be increased when clomethiazole is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with clomethiazole.Approved, Illicit
GuanfacineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with clomethiazole.Approved, Illicit, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with clomethiazole.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with clomethiazole.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with clomethiazole.Approved, Illicit, Investigational
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with clomethiazole.Approved
Hydrocodoneclomethiazole may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with clomethiazole.Approved, Illicit
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of clomethiazole.Approved
IdelalisibThe metabolism of clomethiazole can be decreased when combined with Idelalisib.Approved
IloperidoneThe risk or severity of adverse effects can be increased when clomethiazole is combined with Iloperidone.Approved
ImatinibThe metabolism of clomethiazole can be decreased when combined with Imatinib.Approved
ImipramineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Imipramine.Approved
IndalpineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Indalpine.Investigational, Withdrawn
IndinavirThe metabolism of clomethiazole can be decreased when combined with Indinavir.Approved
IndiplonThe risk or severity of adverse effects can be increased when clomethiazole is combined with Indiplon.Investigational
IsavuconazoniumThe metabolism of clomethiazole can be decreased when combined with Isavuconazonium.Approved, Investigational
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with clomethiazole.Approved, Vet Approved
IsoniazidThe metabolism of clomethiazole can be decreased when combined with Isoniazid.Approved
IsradipineThe metabolism of clomethiazole can be decreased when combined with Isradipine.Approved
ItraconazoleThe metabolism of clomethiazole can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of clomethiazole can be increased when it is combined with Ivacaftor.Approved
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with clomethiazole.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Ketazolam is combined with clomethiazole.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when clomethiazole is combined with Ketobemidone.Approved, Investigational
KetoconazoleThe metabolism of clomethiazole can be decreased when combined with Ketoconazole.Approved, Investigational
LamotrigineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Lamotrigine.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when clomethiazole is combined with Levetiracetam.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with clomethiazole.Approved, Investigational
LevocabastineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when clomethiazole is combined with Levodopa.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with clomethiazole.Approved, Investigational
LevomilnacipranThe risk or severity of adverse effects can be increased when clomethiazole is combined with Levomilnacipran.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with clomethiazole.Approved
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with clomethiazole.Approved, Vet Approved
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with clomethiazole.Approved
LobeglitazoneThe metabolism of clomethiazole can be decreased when combined with Lobeglitazone.Approved, Investigational
LofentanilThe risk or severity of adverse effects can be increased when clomethiazole is combined with Lofentanil.Illicit
LopinavirThe metabolism of clomethiazole can be decreased when combined with Lopinavir.Approved
LoprazolamThe risk or severity of adverse effects can be increased when clomethiazole is combined with Loprazolam.Experimental
LoratadineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Loratadine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with clomethiazole.Approved
LormetazepamThe risk or severity of adverse effects can be increased when clomethiazole is combined with Lormetazepam.Approved
LovastatinThe metabolism of clomethiazole can be decreased when combined with Lovastatin.Approved, Investigational
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with clomethiazole.Approved
LuliconazoleThe serum concentration of clomethiazole can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of clomethiazole can be decreased when it is combined with Lumacaftor.Approved
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with clomethiazole.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of clomethiazole.Approved, Vet Approved
MaprotilineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Maprotiline.Approved
MebicarThe risk or severity of adverse effects can be increased when clomethiazole is combined with Mebicar.Experimental
MeclizineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Meclizine.Approved
MedazepamThe risk or severity of adverse effects can be increased when clomethiazole is combined with Medazepam.Experimental
MedetomidineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Medetomidine.Vet Approved
MefloquineThe therapeutic efficacy of clomethiazole can be decreased when used in combination with Mefloquine.Approved
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with clomethiazole.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when clomethiazole is combined with Melperone.Approved, Investigational
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with clomethiazole.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with clomethiazole.Approved, Illicit
MeptazinolThe risk or severity of adverse effects can be increased when clomethiazole is combined with Meptazinol.Experimental
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with clomethiazole.Approved, Investigational
MetaxaloneThe risk or severity of adverse effects can be increased when clomethiazole is combined with Metaxalone.Approved
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with clomethiazole.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with clomethiazole.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with clomethiazole.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with clomethiazole.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when clomethiazole is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with clomethiazole.Approved
Methotrimeprazineclomethiazole may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with clomethiazole.Approved, Investigational, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when clomethiazole is combined with Methsuximide.Approved
MethylecgonineThe risk or severity of adverse effects can be increased when Methylecgonine is combined with clomethiazole.Experimental
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with clomethiazole.Approved
Metyrosineclomethiazole may increase the sedative activities of Metyrosine.Approved
MianserinThe therapeutic efficacy of clomethiazole can be decreased when used in combination with Mianserin.Approved, Investigational
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with clomethiazole.Approved, Illicit
MifepristoneThe serum concentration of clomethiazole can be increased when it is combined with Mifepristone.Approved, Investigational
MilnacipranThe risk or severity of adverse effects can be increased when clomethiazole is combined with Milnacipran.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of clomethiazole.Approved, Investigational
Mirtazapineclomethiazole may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MitotaneThe serum concentration of clomethiazole can be decreased when it is combined with Mitotane.Approved
MoclobemideThe metabolism of clomethiazole can be decreased when combined with Moclobemide.Approved
ModafinilThe metabolism of clomethiazole can be decreased when combined with Modafinil.Approved, Investigational
MolindoneThe risk or severity of adverse effects can be increased when Molindone is combined with clomethiazole.Approved
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with clomethiazole.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of clomethiazole.Approved, Investigational
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with clomethiazole.Approved
NefazodoneThe metabolism of clomethiazole can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of clomethiazole can be decreased when combined with Nelfinavir.Approved
NetupitantThe serum concentration of clomethiazole can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of clomethiazole can be increased when combined with Nevirapine.Approved
NicardipineThe metabolism of clomethiazole can be decreased when combined with Nicardipine.Approved
NicotineThe metabolism of clomethiazole can be decreased when combined with Nicotine.Approved
NilotinibThe metabolism of clomethiazole can be decreased when combined with Nilotinib.Approved, Investigational
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with clomethiazole.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with clomethiazole.Approved, Vet Approved
NorfluraneThe risk or severity of adverse effects can be increased when clomethiazole is combined with Norflurane.Investigational
NormethadoneThe risk or severity of adverse effects can be increased when clomethiazole is combined with Normethadone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Nortriptyline.Approved
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with clomethiazole.Approved, Investigational
OlaparibThe metabolism of clomethiazole can be decreased when combined with Olaparib.Approved
OlopatadineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Olopatadine.Approved
OmeprazoleThe metabolism of clomethiazole can be decreased when combined with Omeprazole.Approved, Investigational, Vet Approved
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with clomethiazole.Approved
OpiumThe risk or severity of adverse effects can be increased when clomethiazole is combined with Opium.Approved, Illicit
OrlistatThe serum concentration of clomethiazole can be decreased when it is combined with Orlistat.Approved, Investigational
Orphenadrineclomethiazole may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Osanetant is combined with clomethiazole.Investigational
OsimertinibThe serum concentration of clomethiazole can be increased when it is combined with Osimertinib.Approved
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with clomethiazole.Approved
OxethazaineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Oxethazaine.Approved, Investigational
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with clomethiazole.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with clomethiazole.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with clomethiazole.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with clomethiazole.Approved, Investigational, Vet Approved
PalbociclibThe serum concentration of clomethiazole can be increased when it is combined with Palbociclib.Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with clomethiazole.Approved
PantoprazoleThe metabolism of clomethiazole can be decreased when combined with Pantoprazole.Approved
Paraldehydeclomethiazole may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
ParoxetineThe metabolism of clomethiazole can be decreased when combined with Paroxetine.Approved, Investigational
PenfluridolThe risk or severity of adverse effects can be increased when clomethiazole is combined with Penfluridol.Experimental
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with clomethiazole.Approved, Vet Approved
PentobarbitalThe metabolism of clomethiazole can be increased when combined with Pentobarbital.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of clomethiazole.Approved
PerazineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Perazine.Investigational
PerospironeThe risk or severity of adverse effects can be increased when clomethiazole is combined with Perospirone.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with clomethiazole.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with clomethiazole.Approved
PhenazocineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Phenazocine.Experimental
PhenibutThe risk or severity of adverse effects can be increased when clomethiazole is combined with Phenibut.Experimental
PhenobarbitalThe metabolism of clomethiazole can be increased when combined with Phenobarbital.Approved
PhenoperidineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Phenoperidine.Experimental
PhenoxyethanolThe risk or severity of adverse effects can be increased when clomethiazole is combined with Phenoxyethanol.Approved
PhenytoinThe metabolism of clomethiazole can be increased when combined with Phenytoin.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with clomethiazole.Approved
PipamperoneThe risk or severity of adverse effects can be increased when clomethiazole is combined with Pipamperone.Approved, Investigational
PipotiazineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Pipotiazine.Approved, Investigational
PiritramideThe risk or severity of adverse effects can be increased when clomethiazole is combined with Piritramide.Investigational
PizotifenThe risk or severity of adverse effects can be increased when clomethiazole is combined with Pizotifen.Approved
PomalidomideThe risk or severity of adverse effects can be increased when clomethiazole is combined with Pomalidomide.Approved
PosaconazoleThe metabolism of clomethiazole can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
Pramipexoleclomethiazole may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Pramocaine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with clomethiazole.Approved, Illicit
PregabalinThe therapeutic efficacy of clomethiazole can be decreased when used in combination with Pregabalin.Approved, Illicit, Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with clomethiazole.Approved
PrimidoneThe metabolism of clomethiazole can be increased when combined with Primidone.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with clomethiazole.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with clomethiazole.Approved, Vet Approved
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with clomethiazole.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Promethazine.Approved
PropanididThe risk or severity of adverse effects can be increased when clomethiazole is combined with Propanidid.Experimental
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with clomethiazole.Approved, Vet Approved
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with clomethiazole.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Propoxycaine.Approved
ProtriptylineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Protriptyline.Approved
ProxibarbalThe risk or severity of adverse effects can be increased when clomethiazole is combined with Proxibarbal.Experimental
PSD502The risk or severity of adverse effects can be increased when clomethiazole is combined with PSD502.Investigational
QuazepamThe serum concentration of clomethiazole can be increased when it is combined with Quazepam.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with clomethiazole.Approved
QuinisocaineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Quinisocaine.Experimental
RacloprideThe risk or severity of adverse effects can be increased when clomethiazole is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when clomethiazole is combined with Ramelteon.Approved, Investigational
RanolazineThe metabolism of clomethiazole can be decreased when combined with Ranolazine.Approved, Investigational
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with clomethiazole.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with clomethiazole.Approved, Withdrawn
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with clomethiazole.Approved, Investigational
RifabutinThe metabolism of clomethiazole can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of clomethiazole can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of clomethiazole can be increased when combined with Rifapentine.Approved
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with clomethiazole.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when clomethiazole is combined with Ritanserin.Investigational
RomifidineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Romifidine.Vet Approved
Ropiniroleclomethiazole may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with clomethiazole.Approved
Rotigotineclomethiazole may increase the sedative activities of Rotigotine.Approved
RucaparibThe metabolism of clomethiazole can be decreased when combined with Rucaparib.Approved, Investigational
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with clomethiazole.Approved
SaquinavirThe metabolism of clomethiazole can be decreased when combined with Saquinavir.Approved, Investigational
SarilumabThe therapeutic efficacy of clomethiazole can be decreased when used in combination with Sarilumab.Approved
ScopolamineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Scopolamine.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with clomethiazole.Approved, Vet Approved
SepranoloneThe risk or severity of adverse effects can be increased when clomethiazole is combined with Sepranolone.Investigational
SertindoleThe risk or severity of adverse effects can be increased when Sertindole is combined with clomethiazole.Approved, Investigational, Withdrawn
SertralineThe metabolism of clomethiazole can be decreased when combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with clomethiazole.Approved, Vet Approved
SildenafilThe metabolism of clomethiazole can be decreased when combined with Sildenafil.Approved, Investigational
SiltuximabThe serum concentration of clomethiazole can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of clomethiazole can be increased when it is combined with Simeprevir.Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of clomethiazole.Approved
SorafenibThe metabolism of clomethiazole can be decreased when combined with Sorafenib.Approved, Investigational
St. John's WortThe serum concentration of clomethiazole can be decreased when it is combined with St. John's Wort.Investigational, Nutraceutical
StiripentolThe serum concentration of clomethiazole can be increased when it is combined with Stiripentol.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with clomethiazole.Approved, Investigational
SulfisoxazoleThe metabolism of clomethiazole can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with clomethiazole.Approved, Investigational
SultoprideThe risk or severity of adverse effects can be increased when clomethiazole is combined with Sultopride.Experimental
Suvorexantclomethiazole may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TandospironeThe risk or severity of adverse effects can be increased when clomethiazole is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of clomethiazole.Approved
TasimelteonThe risk or severity of adverse effects can be increased when clomethiazole is combined with Tasimelteon.Approved
TelaprevirThe metabolism of clomethiazole can be decreased when combined with Telaprevir.Approved, Withdrawn
TelithromycinThe metabolism of clomethiazole can be decreased when combined with Telithromycin.Approved
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with clomethiazole.Approved
TetrabenazineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Tetracaine.Approved, Vet Approved
TetrahydropalmatineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Tetrahydropalmatine.Investigational
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with clomethiazole.Investigational
Thalidomideclomethiazole may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with clomethiazole.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with clomethiazole.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with clomethiazole.Approved, Withdrawn
ThiotepaThe metabolism of clomethiazole can be decreased when combined with Thiotepa.Approved
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with clomethiazole.Approved
TiagabineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when clomethiazole is combined with Tiapride.Approved, Investigational
TiclopidineThe metabolism of clomethiazole can be decreased when combined with Ticlopidine.Approved
TiletamineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Tiletamine.Vet Approved
TilidineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Tilidine.Experimental
TizanidineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Tizanidine.Approved
TocilizumabThe serum concentration of clomethiazole can be decreased when it is combined with Tocilizumab.Approved
TolcaponeThe risk or severity of adverse effects can be increased when clomethiazole is combined with Tolcapone.Approved, Withdrawn
TopiramateThe risk or severity of adverse effects can be increased when clomethiazole is combined with Topiramate.Approved
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with clomethiazole.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with clomethiazole.Experimental
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with clomethiazole.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with clomethiazole.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with clomethiazole.Approved
Tricaine methanesulfonateThe risk or severity of adverse effects can be increased when clomethiazole is combined with Tricaine methanesulfonate.Vet Approved
TrichloroethyleneThe risk or severity of adverse effects can be increased when clomethiazole is combined with Trichloroethylene.Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with clomethiazole.Approved
TrifluperidolThe risk or severity of adverse effects can be increased when clomethiazole is combined with Trifluperidol.Experimental
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with clomethiazole.Approved, Vet Approved
TrimipramineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Triprolidine.Approved
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with clomethiazole.Approved, Investigational
VemurafenibThe serum concentration of clomethiazole can be decreased when it is combined with Vemurafenib.Approved
VenlafaxineThe metabolism of clomethiazole can be decreased when combined with Venlafaxine.Approved
VeraliprideThe risk or severity of adverse effects can be increased when clomethiazole is combined with Veralipride.Experimental
VerapamilThe metabolism of clomethiazole can be decreased when combined with Verapamil.Approved
VigabatrinThe risk or severity of adverse effects can be increased when clomethiazole is combined with Vigabatrin.Approved
Vinyl etherThe risk or severity of adverse effects can be increased when clomethiazole is combined with Vinyl ether.Experimental
VoriconazoleThe metabolism of clomethiazole can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Vortioxetine.Approved
XenonThe risk or severity of adverse effects can be increased when clomethiazole is combined with Xenon.Experimental
XylazineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Xylazine.Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with clomethiazole.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when clomethiazole is combined with Ziconotide.Approved
ZimelidineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Zimelidine.Withdrawn
ZiprasidoneThe metabolism of clomethiazole can be decreased when combined with Ziprasidone.Approved
ZolazepamThe risk or severity of adverse effects can be increased when clomethiazole is combined with Zolazepam.Vet Approved
Zolpidemclomethiazole may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when clomethiazole is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with clomethiazole.Approved
ZotepineThe risk or severity of adverse effects can be increased when clomethiazole is combined with Zotepine.Approved, Investigational
ZucapsaicinThe metabolism of clomethiazole can be decreased when combined with Zucapsaicin.Approved
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with clomethiazole.Approved, Investigational
Food Interactions
Not Available

References

General References
  1. Lyden PD, Ashwood T, Claesson L, Odergren T, Friday GH, Martin-Munley S: The clomethiazole acute stroke study in ischemic, hemorrhagic, and t-PA treated stroke: Design of a phase III trial in the united states and canada. J Stroke Cerebrovasc Dis. 1998 Nov-Dec;7(6):435-41. [PubMed:17895123]
  2. Millis SR, Straube D, Iramaneerat C, Smith EV Jr, Lyden P: Measurement properties of the National Institutes of Health Stroke Scale for people with right- and left-hemisphere lesions: further analysis of the clomethiazole for acute stroke study-ischemic (class-I) trial. Arch Phys Med Rehabil. 2007 Mar;88(3):302-8. [PubMed:17321821]
External Links
PubChem Compound
10783
PubChem Substance
347827773
ChemSpider
10327
BindingDB
234400
ChEBI
92875
ChEMBL
CHEMBL315795
Wikipedia
Chlormethiazole
ATC Codes
N05CX04 — Clomethiazole, combinationsN05CM02 — Clomethiazole

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3TerminatedTreatmentAnxiety Disorders / Dementias / Depression / Psychosomatic Disorders / Schizophrenic Disorders1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.674 mg/mLALOGPS
logP2.47ALOGPS
logP1.77ChemAxon
logS-2.4ALOGPS
pKa (Strongest Basic)3.18ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area12.89 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity40.37 m3·mol-1ChemAxon
Polarizability16.14 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as 4,5-disubstituted thiazoles. These are compounds containing a thiazole ring substituted at positions 4 and 5 only.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Azoles
Sub Class
Thiazoles
Direct Parent
4,5-disubstituted thiazoles
Alternative Parents
Heteroaromatic compounds / Azacyclic compounds / Organopnictogen compounds / Organonitrogen compounds / Organochlorides / Hydrocarbon derivatives / Alkyl chlorides
Substituents
4,5-disubstituted 1,3-thiazole / Heteroaromatic compound / Azacycle / Organic nitrogen compound / Organopnictogen compound / Hydrocarbon derivative / Organonitrogen compound / Organochloride / Organohalogen compound / Alkyl halide
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
a thiazole (CPD-10432)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Inhibitory extracellular ligand-gated ion channel activity
Specific Function
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine...
Gene Name
GABRA1
Uniprot ID
P14867
Uniprot Name
Gamma-aminobutyric acid receptor subunit alpha-1
Molecular Weight
51801.395 Da

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Const...
Gene Name
CYP2A6
Uniprot ID
P11509
Uniprot Name
Cytochrome P450 2A6
Molecular Weight
56501.005 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2B6
Uniprot ID
P20813
Uniprot Name
Cytochrome P450 2B6
Molecular Weight
56277.81 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and im...
Gene Name
CYP2C19
Uniprot ID
P33261
Uniprot Name
Cytochrome P450 2C19
Molecular Weight
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]

Drug created on March 19, 2008 10:34 / Updated on December 01, 2017 17:30