Displaying drugs 76 - 100 of 9360 in total
Mefloquine
Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and...
Approved
Investigational
Matched Synonyms: … alpha-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol ... [(R*,S*)-2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol …
Matched Iupac: … [2,8-bis(trifluoromethyl)quinolin-4-yl](piperidin-2-yl)methanol …
Matched Description: … Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around …
Matched Iupac: … [2,8-bis(trifluoromethyl)quinolin-4-yl](piperidin-2-yl)methanol …
Matched Description: … Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around …
Cinnarizine
First synthesized by Janssen Pharmaceuticals in 1955, cinnarizine is an anti-histaminic drug mainly used for the control of vestibular disorders and motion sickness. Cinnarizine is a specific calcium channel blocker that primarily works on the central vestibular system to interfere with the signal transmission between vestibular apparatus of the inner...
Approved
Investigational
Matched Synonyms: … 1-Benzhydryl-4-cinnamylpiperazin ... 1-Cinnamyl-4-(diphenylmethyl)piperazine ... 1-(Diphenylmethyl)-4-(3-phenyl-2-propenyl)piperazine …
Matched Iupac: … 1-(diphenylmethyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine …
Matched Iupac: … 1-(diphenylmethyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine …
Entrectinib
Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positive solid tumors. Entrectinib's...
Approved
Investigational
Matched Synonyms: … N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(oxan-4-ylamino)benzamide …
Matched Iupac: … N-{5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl}-4-(4-methylpiperazin-1-yl)-2-[(oxan-4-yl)amino]benzamide …
Matched Iupac: … N-{5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl}-4-(4-methylpiperazin-1-yl)-2-[(oxan-4-yl)amino]benzamide …
Aminophenazone
Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic properties that carries a risk of agranulocytosis. In biomedical applications, radiolabelled (13C-labeled) aminophenazone has been used in breath tests to measure the cytochrome P-450 metabolic activity in liver function tests. The FDA suspended the use of aminophenazone due to its association...
Approved
Withdrawn
Matched Synonyms: … 4-Dimethylaminophenazone ... 4-Dimethylaminoantipyrine ... 4-(Dimethylamino)antipyrine …
Matched Iupac: … 4-(dimethylamino)-1,5-dimethyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-one …
Matched Iupac: … 4-(dimethylamino)-1,5-dimethyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-one …
Bosutinib
Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q11), resulting in a BCR-ABL fusion protein.[A6902,A261796,A261801] The first BCR-ABL inhibitor,...
Approved
Matched Synonyms: … 4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)-3-quinolinecarbonitrile …
Matched Iupac: … 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile …
Matched Salts cas: … 918639-08-4 …
Matched Iupac: … 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile …
Matched Salts cas: … 918639-08-4 …
Bumetanide
Bumetanide is a sulfamyl diuretic.
Approved
Matched Synonyms: … 3-butylamino-4-(phenoxy)-5-sulfamoylbenzoic acid ... 3-butylamino-4-phenoxy-5-sulfamoyl-benzoic acid ... 3-butylamino-4-phenoxy-5-sulfamoylbenzoic acid …
Matched Iupac: … 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid …
Matched Iupac: … 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid …
Terfenadine
In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation.
Approved
Withdrawn
Matched Synonyms: … (RS)-1-(4-tert-butylphenyl)-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}-butan-1-ol …
Matched Iupac: … 1-(4-tert-butylphenyl)-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butan-1-ol …
Matched Iupac: … 1-(4-tert-butylphenyl)-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butan-1-ol …
Alfentanil
A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients.
Approved
Illicit
Matched Synonyms: … N-(1-(2-(4-Ethyl-5-oxo-2-tetrazolin-1-yl)ethyl)-4-(methoxymethyl)-4-piperidyl)propionanilide …
Matched Iupac: … N-{1-[2-(4-ethyl-5-oxo-4,5-dihydro-1H-1,2,3,4-tetrazol-1-yl)ethyl]-4-(methoxymethyl)piperidin-4-yl}-N-phenylpropanamide …
Matched Iupac: … N-{1-[2-(4-ethyl-5-oxo-4,5-dihydro-1H-1,2,3,4-tetrazol-1-yl)ethyl]-4-(methoxymethyl)piperidin-4-yl}-N-phenylpropanamide …
Elacestrant
Elacestrant is a non-steroidal small molecule and an estrogen receptor (ER) antagonist.[A256838,L44918] In January 2023, it was approved by the FDA for the treatment of ER-positive, HER2-negative, ESR1-mutated advanced or metastatic breast cancer.[L44918,L44948] It received a similar approval in the EU in September 2023. Elacestrant binds to estrogen receptor-alpha (ERα)...
Approved
Investigational
Matched Synonyms: … (2R)-2-(2-(ethyl-((4-(2-(ethylamino)ethyl)phenyl)methyl)amino)-4-methoxy-phenyl)tetralin-6-ol ... (6R)-6-(2-(ethyl((4-(2- (ethylamino)ethyl)phenyl)methyl)amino)-4-methoxyphenyl)- 5,6,7,8-tetrahydronaphthalen ... 2-naphthalenol, 6-(2-(ethyl((4-(2-(ethylamino)ethyl)phenyl)methyl)amino)-4-methoxyphenyl)-5,6,7,8-tetrahydro …
Matched Iupac: … (6R)-6-{2-[ethyl({4-[2-(ethylamino)ethyl]phenyl}methyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen …
Matched Iupac: … (6R)-6-{2-[ethyl({4-[2-(ethylamino)ethyl]phenyl}methyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen …
Dyclonine
Dyclonine is an oral anaesthetic found in Sucrets, an over the counter throat lozenge. It may also be found in some Cepacol sore throat spray products.
Approved
Matched Synonyms: … 4-butoxy-β-piperidinopropiophenone ... 3-piperidino-4'-butoxypropiophenone ... 4'-butoxy-3-piperidinopropiophenone …
Matched Iupac: … 1-(4-butoxyphenyl)-3-(piperidin-1-yl)propan-1-one …
Matched Iupac: … 1-(4-butoxyphenyl)-3-(piperidin-1-yl)propan-1-one …
Ceritinib
Ceritinib is used for the treatment of adults with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) following failure (secondary to resistance or intolerance) of prior crizotinib therapy. About 4% of patients with NSCLC have a chromosomal rearrangement that generates a fusion gene between EML4 (echinoderm microtubule-associated protein-like...
Approved
Matched Synonyms: … N-{2-[(5-chloro-2-{[2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl} …
Matched Iupac: … 5-chloro-N2-[5-methyl-4-(piperidin-4-yl)-2-(propan-2-yloxy)phenyl]-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine …
Matched Description: … About 4% of patients with NSCLC have a chromosomal rearrangement that generates a fusion gene between ... EML4 (echinoderm microtubule-associated protein-like 4) and ALK (anaplastic lymphoma kinase), which …
Matched Iupac: … 5-chloro-N2-[5-methyl-4-(piperidin-4-yl)-2-(propan-2-yloxy)phenyl]-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine …
Matched Description: … About 4% of patients with NSCLC have a chromosomal rearrangement that generates a fusion gene between ... EML4 (echinoderm microtubule-associated protein-like 4) and ALK (anaplastic lymphoma kinase), which …
Hydroquinone
Hydroquinone is a topical lightening product found in OTC products, and is used to correct skin discoloration associated with disorders of hyperpigmentation including melasma, post-inflammatory hyperpigmention, sunspots, and freckles. It can be used alone, but is more frequently found in combination with other agents such as alpha-hydroxy acids, corticosteroids, retinoids,...
Approved
Investigational
Matched Synonyms: … 4-Hydroxyphenol …
Matched Mixtures name: … Hydroquinone 4% / Tretinoin 0.025% ... Ultraquin 4% Hydroquinone Cream With Sunscreens ... Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% …
Matched Products: … Active 4 ... Clarite 4 ... Seequin 4 …
Matched Mixtures name: … Hydroquinone 4% / Tretinoin 0.025% ... Ultraquin 4% Hydroquinone Cream With Sunscreens ... Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% …
Matched Products: … Active 4 ... Clarite 4 ... Seequin 4 …
Methotrexate
Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division in neoplastic diseases such...
Approved
Matched Synonyms: … 4-amino-10-methylfolic acid ... 4-amino-N(10)-methylpteroylglutamic acid ... N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid …
Matched Iupac: … (2S)-2-[(4-{[(4-amino-2-imino-2,3-dihydropteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic …
Matched Products: … METHOTREXAT 'EBEWE' PFS 10 MG/1 ML KULLANIMA HAZIR ENJEKTÖR, 4 ADET ... METHOTREXAT 'EBEWE' PFS 20 MG/2 ML KULLANIMA HAZIR ENJEKTÖR, 4 ADET ... METHOTREXAT 'EBEWE' PFS 15 MG/1,5 ML KULLANIMA HAZIR ENJEKTÖR, 4 ADET …
Matched Iupac: … (2S)-2-[(4-{[(4-amino-2-imino-2,3-dihydropteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic …
Matched Products: … METHOTREXAT 'EBEWE' PFS 10 MG/1 ML KULLANIMA HAZIR ENJEKTÖR, 4 ADET ... METHOTREXAT 'EBEWE' PFS 20 MG/2 ML KULLANIMA HAZIR ENJEKTÖR, 4 ADET ... METHOTREXAT 'EBEWE' PFS 15 MG/1,5 ML KULLANIMA HAZIR ENJEKTÖR, 4 ADET …
Dobutamine
A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery.
Approved
Matched Synonyms: … 4-{2-[3-(4-Hydroxy-phenyl)-1-methyl-propylamino]-ethyl}-benzene-1,2-diol ... (±)-4-(2-((3-(p-hydroxyphenyl)-1-methylpropyl)amino)ethyl)pyrocatechol ... 3,4-dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-β-phenylethylamine …
Matched Iupac: … 4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol …
Matched Iupac: … 4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol …
Propylthiouracil
A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)
Approved
Investigational
Matched Synonyms: … 4-propyl-2-thiouracil ... 6-Thio-4-propyluracil ... 2-Mercapto-6-propyl-4-pyrimidone …
Matched Iupac: … 6-propyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidin-4-one …
Matched Iupac: … 6-propyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidin-4-one …
Fexofenadine
Fexofenadine is an over-the-counter second-generation antihistamine used in the treatment of various allergic symptoms. It is selective for the H1 receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain barrier - this is in contrast to previous first-generation antihistamines, such as diphenhydramine, which readily bind to off-targets...
Approved
Investigational
Matched Synonyms: … 4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-alpha,alpha-dimethylbenzeneacetic acid …
Matched Iupac: … 2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyl}phenyl)-2-methylpropanoic acid …
Matched Iupac: … 2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyl}phenyl)-2-methylpropanoic acid …
Phenylbutyric acid
Phenylbutyric acid is a fatty acid and a derivative of butyric acid naturally produced by colonic bacteria fermentation. It demonstrates a number of cellular and biological effects, such as relieving inflammation and acting as a chemical chaperone. It is used to treat genetic metabolic syndromes, neuropathies, and urea cycle disorders.[L386,L42105]
Approved
Investigational
Matched Synonyms: … 4-phenylbutyrate ... 4-phenylbutyric acid ... 4-Phenyl-n-butyric acid …
Matched Iupac: … 4-phenylbutanoic acid …
Matched Iupac: … 4-phenylbutanoic acid …
Empagliflozin
Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 diabetes mellitus. The first known inhibitor...
Approved
Matched Synonyms: … 1-chloro-4-(glucopyranos-1-yl)-2-(4-(tetrahydrofuran-3-yloxy)benzyl)benzene ... (1S)-1,5-anhydro-1-(4-chloro-3-{4-[(3S)-tetrahydrofuran-3-yloxy]benzyl}phenyl)-D-glucitol …
Matched Iupac: … (2S,3R,4R,5S,6R)-2-[4-chloro-3-({4-[(3S)-oxolan-3-yloxy]phenyl}methyl)phenyl]-6-(hydroxymethyl)oxane- …
Matched Iupac: … (2S,3R,4R,5S,6R)-2-[4-chloro-3-({4-[(3S)-oxolan-3-yloxy]phenyl}methyl)phenyl]-6-(hydroxymethyl)oxane- …
Coagulation Factor IX (Recombinant)
Recombinant Coagulation Factor IX is a purified Factor IX glycoprotein produced by recombinant DNA technology. It has a primary amino acid sequence that is identical to the Ala148 allelic form of human factor IX, and has structural and functional characteristics similar to those of endogenous factor IX. It is not...
Approved
Investigational
Matched Synonyms: … Coagulation factor IX recombinant human …
Matched Description: … It is not derived from human blood (unlike human Factor IX complex), and is instead produced by a genetically ... It has a primary amino acid sequence that is identical to the Ala148 allelic form of human factor IX, …
Matched Description: … It is not derived from human blood (unlike human Factor IX complex), and is instead produced by a genetically ... It has a primary amino acid sequence that is identical to the Ala148 allelic form of human factor IX, …
Loncastuximab tesirine
Relapsed and refractory B-cell acute lymphoblastic leukemia (B-ALL) are a therapeutic challenge for patients who have undergone prior systemic therapies with limited success. Prognosis is poor and more effective therapies are needed to treat relapsed/refractory cases and improve survival. On April 23 2021, the Food and Drug Administration granted accelerated...
Approved
Investigational
Matched Synonyms: … Humanized monoclonal immunoglobulin G1 antibody directed against human CD19 conjugated to SG3199 through …
Butoconazole
Butoconazole is an imidazole antifungal used in gynecology.
Approved
Matched Synonyms: … 1-[4-(4-Chloro-phenyl)-2-(2,6-dichloro-phenylsulfanyl)-butyl]-1H-imidazole …
Matched Iupac: … 1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)sulfanyl]butyl]-1H-imidazole …
Matched Iupac: … 1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)sulfanyl]butyl]-1H-imidazole …
PBT-434
Approved
Investigational
Matched Synonyms: … 5,7-dichloro-2-((ethylamino)methyl)-8-hydroxy-3-methylquinazolin-4(3h)-one …
Matched Iupac: … 5,7-dichloro-2-[(ethylamino)methyl]-8-hydroxy-3-methyl-3,4-dihydroquinazolin-4-one …
Matched Iupac: … 5,7-dichloro-2-[(ethylamino)methyl]-8-hydroxy-3-methyl-3,4-dihydroquinazolin-4-one …
Follitropin
Follitropin is a human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78...
Approved
Matched Synonyms: … Recombinant human follicle stimulating hormone beta ... Recombinant human follicle-stimulating hormone (r-HFSH) …
Matched Description: … Follitropin is a human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which ... The nomenclature “beta” differentiates it from another recombinant human FSH product that was marketed ... Given by subcutaneous injection, it is used in combination with human chorionic gonadotropin (hCG) to …
Matched Description: … Follitropin is a human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which ... The nomenclature “beta” differentiates it from another recombinant human FSH product that was marketed ... Given by subcutaneous injection, it is used in combination with human chorionic gonadotropin (hCG) to …
Baclofen
Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. Although originally designed in 1962 to treat epilepsy, baclofen was not effective in treating this condition but instead was shown to reduce spasticity in selected patients. Baclofen was reintroduced in 1971 as a treatment for spasticity and...
Approved
Matched Synonyms: … 4-Amino-3-(4-chlorophenyl)butyric acid ... beta-(4-Chlorophenyl)gaba ... DL-4-Amino-3-p-chlorophenylbutanoic acid …
Matched Iupac: … 4-amino-3-(4-chlorophenyl)butanoic acid …
Matched Iupac: … 4-amino-3-(4-chlorophenyl)butanoic acid …
Mecasermin rinfabate
Mecasermin rinfabate is approved for severe primary insulin-like growth factor (IGF) deficiency or in patients with GH gene deletion who have developed antibodies to growth hormone (GH) . Mecasermin rinfabate is similar to DB01277 in that both drugs contain recombinant DNA origin insulin-like growth factor 1 (IGF-1). Mecasermin rinfabate however,...
Approved
Matched Synonyms: … Recombinant human insulin-like growth factor-I/insulin-like growth factor binding protein-3 …
Displaying drugs 76 - 100 of 9360 in total