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Identification
NameFexofenadine
Accession NumberDB00950  (APRD00349)
TypeSmall Molecule
GroupsApproved
DescriptionFexofenadine hydrochloride (Allegra) is an antihistamine drug used in the treatment of hayfever and similar allergy symptoms. It was developed as a successor of and alternative to terfenadine. Fexofenadine, like other second and third-generation antihistamines, does not readily pass through the blood-brain barrier, and so causes less drowsiness than first-generation histamine-receptor antagonists.
Structure
Thumb
Synonyms
4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-alpha,alpha-dimethylbenzeneacetic acid
Carboxyterfenadine
Fexofenadine
Terfenadine acid metabolite
Terfenadine carboxylate
Terfenadine-COOH
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
AllegraSuspension6 mg/mLOralSanofi Aventis U.S. Llc2006-10-16Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2000-02-25Not applicableUs
Fexofenadine HydrochlorideTablet, film coated60 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2000-02-25Not applicableUs
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Fexofenadine HydrochlorideTablet60 mg/1OralREMEDYREPACK INC.2011-08-222016-10-20Us
Fexofenadine HydrochlorideTablet, film coated60 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-07-01Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralDIRECT RX2015-12-03Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralPhysicians Total Care, Inc.2007-04-04Not applicableUs
Fexofenadine HydrochlorideTablet60 mg/1OralRebel Distributors Corp2009-12-09Not applicableUs
Fexofenadine HydrochlorideTablet60 mg/1OralREMEDYREPACK INC.2011-08-222016-10-13Us
Fexofenadine HydrochlorideTablet, film coated30 mg/1OralMajor Pharmaceuticals2009-06-10Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1Oralbryant ranch prepack2006-04-12Not applicableUs
Fexofenadine HydrochlorideTablet, film coated60 mg/1OralPhysicians Total Care, Inc.2006-08-07Not applicableUs
Fexofenadine HydrochlorideTablet180 mg/1OralRebel Distributors Corp2009-12-09Not applicableUs
Fexofenadine HydrochlorideTablet60 mg/1OralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2009-12-09Not applicableUs
Fexofenadine HydrochlorideTablet, film coated60 mg/1Oralbryant ranch prepack2006-04-12Not applicableUs
Fexofenadine HydrochlorideTablet, film coated60 mg/1OralMajor Pharmaceuticals2009-06-10Not applicableUs
Fexofenadine HydrochlorideTablet, film coated30 mg/1OralPhysicians Total Care, Inc.2005-11-09Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralAphena Pharma Solutions Tennessee, Inc.2010-07-01Not applicableUs
Fexofenadine HydrochlorideTablet180 mg/1OralREMEDYREPACK INC.2013-05-23Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralMajor Pharmaceuticals2009-06-10Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralLake Erie Medical DBA Quality Care Products LLC2005-08-01Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralPd Rx Pharmaceuticals, Inc.2010-05-21Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
24 Hour AllergyTablet180 mg/1OralLIVE BETTER (The Great Atlantic & Pacific Tea Company)2013-03-20Not applicableUs
7 Select Allergy ReliefTablet, film coated180 mg/1Oral7 Eleven2014-04-17Not applicableUs
Allegra 12 HourTablet60 mgOralSanofi Aventis Canada Inc1997-07-10Not applicableCanada
Allegra 24 Hour (120mg)Tablet120 mgOralSanofi Aventis Canada Inc2001-01-09Not applicableCanada
Allegra AllergyTablet, coated180 mg/1OralChattem, Inc.2014-12-17Not applicableUs
Allegra AllergyTablet, film coated60 mg/1OralChattem, Inc.2011-03-03Not applicableUs
Allegra AllergyTablet180 mg/1OralNavajo Manufacturing Company Inc.2016-09-23Not applicableUs
Allegra AllergyTablet, film coated180 mg/1OralChattem, Inc.2011-03-03Not applicableUs
Allegra AllergyTablet180 mg/1OralLil' Drug Store Products, Inc2014-09-01Not applicableUs
Allegra AllergyTablet, film coated180 mg/1OralChattem, Inc.2011-03-03Not applicableUs
Allegra AllergyTablet180 mg/1OralNavajo Manufacturing Co., Inc.2015-05-12Not applicableUs
Aller EaseTablet, film coated60 mg/1OralMeijer Distribution Inc2011-08-24Not applicableUs
Aller EaseTablet, film coated180 mg/1OralMeijer Distribution Inc2011-04-14Not applicableUs
Allergy 24-HRTablet, film coated180 mg/1OralWockhardt USA LLC.2012-02-08Not applicableUs
Allergy 24-HRTablet, film coated30 mg/1OralWockhardt USA LLC.2012-02-08Not applicableUs
Allergy 24-HRTablet, film coated60 mg/1OralWockhardt USA LLC.2012-02-08Not applicableUs
Allergy ReliefTablet, film coated180 mg/1OralSafeway2015-02-02Not applicableUs
Allergy ReliefTablet180 mg/1OralWal Mart Stores, Inc.2011-04-13Not applicableUs
Allergy ReliefTablet, film coated180 mg/1OralH E B2011-06-22Not applicableUs
Allergy ReliefTablet180 mg/1OralP and L Development of New York Corporation2013-03-28Not applicableUs
Allergy ReliefTablet, film coated180 mg/1OralMeijer Distribution Inc2014-06-27Not applicableUs
Allergy ReliefTablet180 mg/1OralSAFEWAY INC2013-04-22Not applicableUs
Allergy ReliefTablet, film coated180 mg/1OralHy Vee Inc2014-02-12Not applicableUs
Allergy ReliefTablet, film coated60 mg/1OralKroger Company2013-12-19Not applicableUs
Allergy ReliefTablet, film coated60 mg/1OralH E B2011-08-24Not applicableUs
Allergy ReliefTablet, film coated60 mg/1OralCVS Pharmacy2011-08-31Not applicableUs
Allergy ReliefTablet180 mg/1OralP & L Development, LLC2016-03-31Not applicableUs
Allergy ReliefTablet, film coated180 mg/1OralKroger Company2011-04-16Not applicableUs
Allergy ReliefTablet, film coated180 mg/1OralHy Vee Inc2015-03-07Not applicableUs
Allergy ReliefTablet, film coated180 mg/1OralPublix Super Markets Inc2012-01-30Not applicableUs
Allergy ReliefTablet, film coated60 mg/1OralMeijer Distribution Inc2015-01-30Not applicableUs
Allergy ReliefTablet, film coated180 mg/1OralRite Aid Corporation2011-04-15Not applicableUs
Allergy ReliefTablet, film coated180 mg/1OralWestern Family Foods Inc2014-09-17Not applicableUs
Allergy ReliefTablet, film coated180 mg/1OralMeijer Distribution Inc2015-03-02Not applicableUs
Allergy ReliefTablet, film coated180 mg/1OralShopko Stores Operating Co., LLC2013-07-08Not applicableUs
Berkley and Jensen Allergy ReliefTablet, film coated180 mg/1OralBJWC2011-08-11Not applicableUs
Care One Aller EaseTablet, film coated180 mg/1OralAmerican Sales Company2011-04-15Not applicableUs
Careone Allergy ReliefTablet, film coated180 mg/1OralAmerican Sales Company2016-10-14Not applicableUs
Childrens Allegra AllergySuspension6 mg/mLOralChattem, Inc.2011-03-03Not applicableUs
Childrens Allegra AllergyTablet, orally disintegrating30 mg/1OralChattem, Inc.2014-01-02Not applicableUs
Childrens Allegra AllergyTablet, orally disintegrating30 mg/1OralChattem, Inc.2011-03-03Not applicableUs
Childrens Aller-ease Fexofenadine HydrochlorideSuspension30 mg/5mLOralCARDINAL HEALTH, INC.2016-06-24Not applicableUs
Childrens AllergySuspension30 mg/5mLOralSupervalu Inc2016-03-01Not applicableUs
Childrens AllergySuspension30 mg/5mLOralTopco Associates LLC2016-03-21Not applicableUs
Childrens Allergy Fexofenadine HydrochlorideSuspension30 mg/5mLOralRugby Laboratories2014-12-19Not applicableUs
Childrens Allergy Fexofenadine HydrochlorideSuspension30 mg/5mLOralChain Drug Consortium, LLC2014-12-19Not applicableUs
Childrens Allergy Fexofenadine HydrochlorideSuspension30 mg/5mLOralMeijer Distribution Inc2014-12-19Not applicableUs
Childrens Allergy Fexofenadine HydrochlorideSuspension30 mg/5mLOralActavis Pharma, Inc.2014-12-22Not applicableUs
Childrens Allergy Fexofenadine HydrochlorideSuspension30 mg/5mLOralPreferred Plus (Kinray)2015-03-01Not applicableUs
Childrens Allergy ReliefSuspension30 mg/5mLOralKroger Company2015-07-01Not applicableUs
Childrens Allergy ReliefSuspension30 mg/5mLOralWal Mart Stores, Inc.2015-07-01Not applicableUs
Childrens Allergy ReliefSuspension30 mg/5mLOralHEB2015-07-01Not applicableUs
Childrens Allergy ReliefSuspension30 mg/5mLOralCVS Pharmacy2014-12-19Not applicableUs
Childrens Allergy ReliefSuspension30 mg/5mLOralRite Aid2014-12-19Not applicableUs
Childrens Wal-fexSuspension30 mg/5mLOralWalgreen Company2014-12-19Not applicableUs
Dg Health Aller EaseTablet, film coated180 mg/1OralDolgencorp, LLC2011-06-06Not applicableUs
Equaline Aller EaseTablet, film coated180 mg/1OralSupervalu Inc2011-04-14Not applicableUs
Equate Allergy ReliefTablet, film coated180 mg/1OralWal Mart Stores Inc2011-04-14Not applicableUs
Exchange Select Aller EaseTablet, film coated180 mg/1OralArmy & Air Force Exchange Service2015-12-23Not applicableUs
Exchange Select Allergy ReliefTablet, film coated180 mg/1OralArmy & Air Force Exchange Service2011-09-26Not applicableUs
Fexo FenadineTablet, film coated180 mg/1OralHy Vee Inc2011-04-17Not applicableUs
Fexo FenadineTablet, film coated180 mg/1OralKroger Company2011-04-16Not applicableUs
Fexo FenadineTablet, film coated60 mg/1OralKroger Company2011-08-16Not applicableUs
FexofenadineTablet, film coated60 mg/1OralWockhardt Limited2012-02-08Not applicableUs
FexofenadineTablet, film coated180 mg/1OralWockhardt Limited2012-02-08Not applicableUs
FexofenadineTablet, film coated180 mg/1OralAmerican Health Packaging2016-02-01Not applicableUs
FexofenadineTablet, film coated60 mg/1OralHy Vee Inc2011-10-24Not applicableUs
FexofenadineTablet, film coated30 mg/1OralWockhardt Limited2012-02-08Not applicableUs
Fexofenadine HClTablet, film coated180 mg/1OralCVS Pharmacy2015-09-16Not applicableUs
Fexofenadine HClTablet180 mg/1OralChain Drug Marketing Association2012-08-27Not applicableUs
Fexofenadine HClTablet, film coated180 mg/1OralCamber Consumer Care2015-09-16Not applicableUs
Fexofenadine HClTablet180 mg/1OralChain Drug Consortium, LLC2012-06-18Not applicableUs
Fexofenadine HClTablet180 mg/1OralPreferred Plus (Kinray)2013-03-31Not applicableUs
Fexofenadine HClTablet180 mg/1OralQUALITY CHOICE (Chain Drug Marketing Association)2016-03-31Not applicableUs
Fexofenadine HClTablet, film coated60 mg/1OralScie Gen Pharmaceuticals, Inc.2014-12-26Not applicableUs
Fexofenadine HClTablet180 mg/1OralValu Merchandisers Company (Best Choice)2012-06-04Not applicableUs
Fexofenadine HClTablet, film coated180 mg/1OralScie Gen Pharmaceuticals, Inc.2014-12-26Not applicableUs
Fexofenadine HClTablet180 mg/1OralShopko Stores Operating Co., LLC.2012-06-11Not applicableUs
Fexofenadine HydrochlorideTablet, film coated60 mg/1OralLake Erie Medical DBA Quality Care Products LLC2011-08-08Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralMcKesson2016-10-14Not applicableUs
Fexofenadine HydrochlorideTablet180 mg/1OralMeijer Distribution, Inc2014-12-29Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralAurohealth LLC2015-01-15Not applicableUs
Fexofenadine HydrochlorideTablet, film coated60 mg/1OralHetero Labs Limited2016-08-23Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-04-14Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralRebel Distributors Corp2011-04-22Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralREMEDYREPACK INC.2013-05-20Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralMajor Pharmaceuticals2011-04-14Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralFred's2015-01-15Not applicableUs
Fexofenadine HydrochlorideTablet, film coated60 mg/1OralDispensing Solutions, Inc.2011-08-08Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralPerrigo New York Inc2011-04-22Not applicableUs
Fexofenadine HydrochlorideTablet, film coated60 mg/1OralAurolife Pharma, LLC2015-08-26Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralDiscount Drug Mart2015-05-06Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralSun Pharmaceutical Industries Limited2012-02-06Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralAv Pak2016-08-16Not applicableUs
Fexofenadine HydrochlorideTablet, film coated60 mg/1OralMcKesson2016-10-12Not applicableUs
Fexofenadine HydrochlorideTablet180 mg/1OralChain Drug Marketing Associate2014-04-01Not applicableUs
Fexofenadine HydrochlorideTablet, film coated60 mg/1OralMylan Pharmaceuticals Inc.2011-08-25Not applicableUs
Fexofenadine HydrochlorideTablet, film coated60 mg/1OralAurohealth LLC2016-10-05Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralWal Mart Stores, Inc2015-09-30Not applicableUs
Fexofenadine HydrochlorideTablet, film coated60 mg/1OralGolden State Medical Supply, Inc.2014-03-20Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralHetero Labs Limited2016-08-23Not applicableUs
Fexofenadine HydrochlorideTablet, film coated60 mg/1OralAv Kare, Inc.2015-10-16Not applicableUs
Fexofenadine HydrochlorideTablet180 mg/1OralMajor Pharmaceuticals2012-09-04Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralDispensing Solutions, Inc.2011-04-14Not applicableUs
Fexofenadine HydrochlorideTablet, film coated60 mg/1OralMylan Institutional Inc.2012-02-13Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralAurolife Pharma, LLC2014-11-19Not applicableUs
Fexofenadine HydrochlorideTablet180 mg/1OralPhysicians Total Care, Inc.2011-07-27Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralProficient Rx LP2011-04-22Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralMagno Humphries Labs, Inc.2015-01-15Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralMcKesson2016-10-12Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralWestern Family Foods Inc2011-04-14Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralGolden State Medical Supply, Inc.2014-03-20Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralMylan Pharmaceuticals Inc.2011-08-25Not applicableUs
Fexofenadine HydrochlorideTablet, film coated30 mg/1OralSun Pharmaceutical Industries Limited2012-02-06Not applicableUs
Fexofenadine HydrochlorideTablet180 mg/1OralChain Drug Consortium, LLC2014-04-01Not applicableUs
Fexofenadine HydrochlorideTablet, film coated60 mg/1OralAvera Mc Kennan Hospital2015-06-01Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralCarilion Materials Management2011-04-22Not applicableUs
Fexofenadine HydrochlorideTablet180 mg/1OralCvs Health Corp.2011-04-01Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralPreferred Pharmaceuticals Inc.2016-12-05Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralAv Kare, Inc.2015-05-01Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralMylan Institutional Inc.2011-09-27Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralSam's West Inc2015-01-15Not applicableUs
Fexofenadine HydrochlorideTablet, film coated60 mg/1OralA S Medication Solutions2011-08-08Not applicableUs
Fexofenadine HydrochlorideTablet, film coated60 mg/1OralMcKesson2016-10-14Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralSafeway2011-04-15Not applicableUs
Fexofenadine HydrochlorideTablet180 mg/1OralDr. Reddy's Laboratories Limited2011-01-03Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralAvera Mc Kennan Hospital2015-03-13Not applicableUs
Fexofenadine HydrochlorideTablet, film coated60 mg/1OralRebel Distributors Corp2011-08-08Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-04-22Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralSt Marys Medical Park Pharmacy2013-01-10Not applicableUs
Fexofenadine HydrochlorideTablet, film coated60 mg/1OralProficient Rx LP2011-08-08Not applicableUs
Fexofenadine HydrochlorideTablet, film coated60 mg/1OralPerrigo New York Inc2011-08-08Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralREMEDYREPACK INC.2016-06-08Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralPreferred Pharmaceuticals, Inc.2016-10-24Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralClinical Solutions Wholesale2011-04-22Not applicableUs
Fexofenadine HydrochlorideTablet, film coated60 mg/1OralSun Pharmaceutical Industries Limited2012-02-06Not applicableUs
Fexofenadine HydrochlorideTablet, film coated60 mg/1OralCarilion Materials Management2011-08-08Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralAmerisource Bergen2015-01-15Not applicableUs
Fexofenadine HydrochlorideTablet, film coated30 mg/1OralHetero Labs Limited2016-08-23Not applicableUs
Fexofenadine HydrochlorideTablet, film coated180 mg/1OralAidarex Pharmaceuticals LLC2011-04-22Not applicableUs
Fexofenadine HydrochlorideTablet, film coated60 mg/1OralBlenheim Pharmacal, Inc.2013-11-13Not applicableUs
Fexofenadine Hydrochloride 180Tablet180 mg/1OralKaiser Permanente2012-07-05Not applicableUs
Fexofenodine HydrochlorideTablet, film coated60 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-08-08Not applicableUs
Good Neighbor Pharmacy Allergy ReliefTablet, film coated180 mg/1OralAmerisource Bergen2014-08-15Not applicableUs
Good Neighbor Pharmacy Allergy ReliefTablet, film coated180 mg/1OralAmerisource Bergen2011-06-22Not applicableUs
Good Sense Aller EaseTablet, film coated60 mg/1OralL Perrigo Company2011-09-14Not applicableUs
Good Sense Aller EaseTablet, film coated180 mg/1OralL. Perrigo Company2011-04-14Not applicableUs
Harris Teeter Allergy ReliefTablet, film coated180 mg/1OralHarris Teeter, LLC2015-06-24Not applicableUs
Health Mart Fexofenadine HydrochlorideTablet, film coated60 mg/1OralMc Kesson2012-01-26Not applicableUs
Health Mart Fexofenadine HydrochlorideTablet, film coated180 mg/1OralMc Kesson2014-04-01Not applicableUs
Health Mart Fexofenadine HydrochlorideTablet, film coated180 mg/1OralMc Kesson2012-01-18Not applicableUs
Healthy Accents Aller Ease 24 HourTablet, film coated180 mg/1OralDZA Brands LLC2011-06-15Not applicableUs
Healthy Accents Allergy ReliefTablet, film coated180 mg/1OralDZA Brands LLC2011-06-15Not applicableUs
Kirkland Signature Aller FexTablet, film coated180 mg/1OralCostco Wholesale Company2011-04-23Not applicableUs
Leader Aller EaseTablet, film coated180 mg/1OralCardinal Health2014-02-05Not applicableUs
Leader Aller EaseTablet, film coated180 mg/1OralCardinal Health2011-05-16Not applicableUs
Members Mark FexofenadineTablet, film coated180 mg/1OralSam's West Inc2011-04-14Not applicableUs
Mucinex AllergyTablet180 mg/1OralReckitt Benckiser LLC2014-01-02Not applicableUs
Preferred Plus Aller EaseTablet, film coated180 mg/1OralKinray2014-06-17Not applicableUs
Preferred Plus Allergy ReliefTablet, film coated180 mg/1OralKinray2014-09-22Not applicableUs
Rugby Fexofenadine HydrochlorideTablet, film coated180 mg/1OralRugby Laboratories2015-01-28Not applicableUs
Shoprite Aller EaseTablet, film coated180 mg/1OralWakefern Food Corporation2013-07-09Not applicableUs
Shoprite Aller EaseTablet, film coated60 mg/1OralWakefern Food Corporation2013-07-09Not applicableUs
Signature Care Allergy ReliefTablet, film coated180 mg/1OralSafeway2015-08-11Not applicableUs
Smart Sense Allergy ReliefTablet, film coated60 mg/1OralKmart Corporation2011-09-01Not applicableUs
Smart Sense Allergy ReliefTablet, film coated180 mg/1OralKmart Corporation2011-06-23Not applicableUs
Smart Sense Allergy ReliefTablet, film coated180 mg/1OralKmart Corporation2014-08-21Not applicableUs
Sunmark Fexofenadine HydrochlorideTablet, film coated180 mg/1OralMc Kesson2011-04-14Not applicableUs
Sunmark Fexofenadine HydrochlorideTablet, film coated60 mg/1OralMc Kesson2011-09-06Not applicableUs
Topcare Allergy ReliefTablet, film coated180 mg/1OralTopco Associates LLC2015-01-07Not applicableUs
Topcare Fexofenadine HydrochlorideTablet, film coated180 mg/1OralTopco Associates LLC2011-04-14Not applicableUs
Topcare Fexofenadine HydrochlorideTablet, film coated60 mg/1OralTopco Associates LLC2011-09-02Not applicableUs
Up and Up Allergy ReliefTablet, film coated180 mg/1OralTarget Corporation2011-04-13Not applicableUs
Up and Up Allergy ReliefTablet, film coated180 mg/1OralTarget Corporation2015-03-25Not applicableUs
Wal FexTablet, film coated60 mg/1OralWalgreen Company2011-08-22Not applicableUs
Wal Fex 24 Hour AllergyTablet, film coated180 mg/1OralWalgreen Company2014-03-06Not applicableUs
Wal Fex AllergyTablet, film coated180 mg/1OralWalgreen Company2011-04-14Not applicableUs
Wal Fex AllergyTablet, film coated60 mg/1OralWalgreen Company2011-08-22Not applicableUs
Wal-fexTablet180 mg/1OralWalgreens Company2011-04-13Not applicableUs
Unapproved/Other Products Not Available
International Brands
NameCompany
FastofenNot Available
FexidineNot Available
TelfastNot Available
VifasNot Available
Brand mixtures
NameLabellerIngredients
Allegra D 12 Hour Allergy and CongestionRebel Distributors Corp
Allegra D-12 HourSanofi Aventis U.S. Llc
Allegra--d 24 HourSanofi Aventis U.S. Llc
Allegra-Dbryant ranch prepack
Allegra-D 24 HourSTAT Rx USA LLC
Allegra-D Allergy and CongestionChattem, Inc.
Fexofenadine HCl and Pseudoephedrine HciWalgreens Company
Fexofenadine HCl and Pseudoephedrine HClDr.Reddy's Laboratories Limited
Fexofenadine Hydrochloride and Pseudoephedrine HydrochlorideRebel Distributors Corp
Salts
Name/CASStructureProperties
Fexofenadine hydrochloride
153439-40-8
Thumb
  • InChI Key: RRJFVPUCXDGFJB-UHFFFAOYSA-N
  • Monoisotopic Mass: 537.2645865
  • Average Mass: 538.13
DBSALT001227
Categories
UNIIE6582LOH6V
CAS number83799-24-0
WeightAverage: 501.6564
Monoisotopic: 501.287908741
Chemical FormulaC32H39NO4
InChI KeyRWTNPBWLLIMQHL-UHFFFAOYSA-N
InChI
InChI=1S/C32H39NO4/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36)
IUPAC Name
2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyl}phenyl)-2-methylpropanoic acid
SMILES
CC(C)(C(O)=O)C1=CC=C(C=C1)C(O)CCCN1CCC(CC1)C(O)(C1=CC=CC=C1)C1=CC=CC=C1
Pharmacology
IndicationFor management of Seasonal allergic rhinitis
Structured Indications
PharmacodynamicsFexofenadine is a second-generation, long lasting H1-receptor antagonist (antihistamine) which has a selective and peripheral H1-antagonist action. Histamine is a chemical that causes many of the signs that are part of allergic reactions, such as the swelling of tissues. Histamine is released from histamine-storing cells (mast cells) and attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cell to be "activated," releasing other chemicals which produce the effects that we associate with allergy. Fexofenadine blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation of cells by histamine. Unlike most other antihistamines, Fexofenadine does not enter the brain from the blood and, therefore, does not cause drowsiness. Fexofenadine lacks the cardiotoxic potential of terfenadine, since it does not block the potassium channel involved in repolarization of cardiac cells.
Mechanism of actionLike other H1-blockers, Fexofenadine competes with free histamine for binding at H1-receptors in the GI tract, large blood vessels, and bronchial smooth muscle. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms (eg. nasal congestion, watery eyes) brought on by histamine. Fexofenadine exhibits no anticholinergic, antidopaminergic, alpha1-adrenergic or beta-adrenergic-receptor blocking effects.
TargetKindPharmacological actionActionsOrganismUniProt ID
Histamine H1 receptorProteinyes
antagonist
HumanP35367 details
Related Articles
Absorption33%
Volume of distributionNot Available
Protein binding60%-70%
Metabolism

Approximately 5% of the total dose is metabolized, by cytochrome P450 3A4 and by intestinal microflora.

Route of eliminationNot Available
Half life14.4 hours
ClearanceNot Available
ToxicitySide effects include dizziness, drowsiness, and dry mouth.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,1,1,2 TetrafluoroethaneThe risk or severity of adverse effects can be increased when Fexofenadine is combined with 1,1,1,2 Tetrafluoroethane.Investigational
2,5-Dimethoxy-4-ethylamphetamine2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative activities of Fexofenadine.Experimental, Illicit
3,4-Methylenedioxyamphetamine3,4-Methylenedioxyamphetamine may decrease the sedative activities of Fexofenadine.Experimental, Illicit
3,4-Methylenedioxymethamphetamine3,4-Methylenedioxymethamphetamine may decrease the sedative activities of Fexofenadine.Experimental, Illicit
4-Bromo-2,5-dimethoxyamphetamine4-Bromo-2,5-dimethoxyamphetamine may decrease the sedative activities of Fexofenadine.Experimental, Illicit
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Fexofenadine.Experimental
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Fexofenadine.Approved
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Fexofenadine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Fexofenadine.Approved
AcetaminophenThe serum concentration of Fexofenadine can be increased when it is combined with Acetaminophen.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Fexofenadine.Approved, Vet Approved
adipiplonThe risk or severity of adverse effects can be increased when adipiplon is combined with Fexofenadine.Investigational
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Fexofenadine.Approved
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Fexofenadine.Approved, Investigational
AlbendazoleThe serum concentration of Fexofenadine can be increased when it is combined with Albendazole.Approved, Vet Approved
AldosteroneThe serum concentration of Fexofenadine can be decreased when it is combined with Aldosterone.Experimental
AlectinibThe serum concentration of Fexofenadine can be increased when it is combined with Alectinib.Approved
AlfaxaloneThe risk or severity of adverse effects can be increased when Alfaxalone is combined with Fexofenadine.Vet Approved
AlfentanilThe serum concentration of Fexofenadine can be increased when it is combined with Alfentanil.Approved, Illicit
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Fexofenadine.Approved, Investigational
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Fexofenadine.Experimental, Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Fexofenadine.Approved, Illicit, Investigational
Aluminum hydroxideThe serum concentration of Fexofenadine can be decreased when it is combined with Aluminum hydroxide.Approved
Aluminum phosphateThe serum concentration of Fexofenadine can be decreased when it is combined with Aluminum phosphate.Approved
AmantadineThe serum concentration of Fexofenadine can be increased when it is combined with Amantadine.Approved
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Fexofenadine.Approved, Investigational
Aminohippuric acidThe serum concentration of Fexofenadine can be increased when it is combined with Aminohippuric acid.Approved
AmiodaroneThe serum concentration of Fexofenadine can be decreased when it is combined with Amiodarone.Approved, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Amisulpride is combined with Fexofenadine.Approved, Investigational
AmitriptylineThe serum concentration of Fexofenadine can be increased when it is combined with Amitriptyline.Approved
AmlodipineThe serum concentration of Fexofenadine can be increased when it is combined with Amlodipine.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Fexofenadine.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Amoxapine is combined with Fexofenadine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Amperozide is combined with Fexofenadine.Experimental
AmphetamineAmphetamine may decrease the sedative activities of Fexofenadine.Approved, Illicit
AmprenavirThe serum concentration of Fexofenadine can be decreased when it is combined with Amprenavir.Approved
AmsacrineThe serum concentration of Fexofenadine can be increased when it is combined with Amsacrine.Approved
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Fexofenadine.Approved
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Fexofenadine.Approved, Investigational
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Fexofenadine.Approved, Investigational
ArticaineThe risk or severity of adverse effects can be increased when Articaine is combined with Fexofenadine.Approved
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Fexofenadine.Approved
AstemizoleThe serum concentration of Fexofenadine can be increased when it is combined with Astemizole.Approved, Withdrawn
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Fexofenadine.Approved, Investigational
AtenololThe serum concentration of Fexofenadine can be increased when it is combined with Atenolol.Approved
AtorvastatinThe serum concentration of Fexofenadine can be increased when it is combined with Atorvastatin.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Fexofenadine.Approved, Investigational
AzaperoneThe risk or severity of adverse effects can be increased when Azaperone is combined with Fexofenadine.Vet Approved
AzelastineFexofenadine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzelastineThe serum concentration of Fexofenadine can be increased when it is combined with Azelastine.Approved
AzithromycinThe serum concentration of Fexofenadine can be increased when it is combined with Azithromycin.Approved
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Fexofenadine.Approved
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Fexofenadine.Illicit
BenperidolThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Benperidol.Investigational
BenzocaineThe serum concentration of Fexofenadine can be increased when it is combined with Benzocaine.Approved
BenzphetamineBenzphetamine may decrease the sedative activities of Fexofenadine.Approved, Illicit
Benzyl alcoholThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Fexofenadine.Approved
Benzylpenicilloyl PolylysineFexofenadine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.Approved
BepridilThe serum concentration of Fexofenadine can be increased when it is combined with Bepridil.Approved, Withdrawn
BetahistineThe therapeutic efficacy of Betahistine can be decreased when used in combination with Fexofenadine.Approved
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Fexofenadine.Approved, Vet Approved
BiperidenThe serum concentration of Fexofenadine can be increased when it is combined with Biperiden.Approved
Bismuth SubcitrateThe serum concentration of Fexofenadine can be decreased when it is combined with Bismuth Subcitrate.Approved
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Fexofenadine.Approved
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Fexofenadine.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Fexofenadine.Approved
BrexpiprazoleThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Brexpiprazole.Approved
BrimonidineThe risk or severity of adverse effects can be increased when Brimonidine is combined with Fexofenadine.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.Approved
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Fexofenadine.Approved, Illicit
BromocriptineThe serum concentration of Fexofenadine can be increased when it is combined with Bromocriptine.Approved, Investigational
BrompheniramineThe risk or severity of adverse effects can be increased when Brompheniramine is combined with Fexofenadine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Fexofenadine.Approved, Withdrawn
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Fexofenadine.Approved, Investigational
BuprenorphineFexofenadine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe serum concentration of Fexofenadine can be increased when it is combined with Buspirone.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Fexofenadine.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Butacaine is combined with Fexofenadine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Butalbital is combined with Fexofenadine.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Butamben is combined with Fexofenadine.Approved
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Fexofenadine.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Fexofenadine.Approved, Illicit, Vet Approved
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Fexofenadine.Approved
CaffeineThe serum concentration of Fexofenadine can be increased when it is combined with Caffeine.Approved
Calcium carbonateThe serum concentration of Fexofenadine can be decreased when it is combined with Calcium carbonate.Approved
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Fexofenadine.Experimental
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Fexofenadine.Approved
CandesartanThe serum concentration of Fexofenadine can be increased when it is combined with Candesartan.Approved
CaptoprilThe serum concentration of Fexofenadine can be increased when it is combined with Captopril.Approved
CarbamazepineThe serum concentration of Fexofenadine can be decreased when it is combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Carbinoxamine is combined with Fexofenadine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Fexofenadine.Illicit, Vet Approved
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Fexofenadine.Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Carisoprodol is combined with Fexofenadine.Approved
CarvedilolThe serum concentration of Fexofenadine can be increased when it is combined with Carvedilol.Approved, Investigational
CaspofunginThe serum concentration of Fexofenadine can be increased when it is combined with Caspofungin.Approved
CeritinibThe serum concentration of Ceritinib can be increased when it is combined with Fexofenadine.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Fexofenadine.Withdrawn
CetirizineThe risk or severity of adverse effects can be increased when Cetirizine is combined with Fexofenadine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Fexofenadine.Approved, Illicit, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Fexofenadine.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Fexofenadine.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Fexofenadine.Approved
ChloroquineThe serum concentration of Fexofenadine can be increased when it is combined with Chloroquine.Approved, Vet Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Chlorphenamine.Approved
ChlorphentermineChlorphentermine may decrease the sedative activities of Fexofenadine.Illicit, Withdrawn
ChlorpromazineThe serum concentration of Fexofenadine can be increased when it is combined with Chlorpromazine.Approved, Vet Approved
ChlorpropamideThe serum concentration of Fexofenadine can be increased when it is combined with Chlorpropamide.Approved
ChlorprothixeneThe serum concentration of Fexofenadine can be increased when it is combined with Chlorprothixene.Approved, Withdrawn
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Fexofenadine.Approved
CholesterolThe serum concentration of Fexofenadine can be increased when it is combined with Cholesterol.Experimental
Cholic AcidThe serum concentration of Fexofenadine can be decreased when it is combined with Cholic Acid.Approved
CilazaprilThe serum concentration of Fexofenadine can be increased when it is combined with Cilazapril.Approved
CimetidineThe serum concentration of Fexofenadine can be decreased when it is combined with Cimetidine.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Fexofenadine.Approved, Vet Approved
CiprofloxacinThe serum concentration of Fexofenadine can be increased when it is combined with Ciprofloxacin.Approved, Investigational
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Fexofenadine.Approved
CitalopramThe serum concentration of Fexofenadine can be increased when it is combined with Citalopram.Approved
ClarithromycinThe serum concentration of Fexofenadine can be increased when it is combined with Clarithromycin.Approved
ClemastineThe risk or severity of adverse effects can be increased when Clemastine is combined with Fexofenadine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Clidinium is combined with Fexofenadine.Approved
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Fexofenadine.Approved, Illicit
ClofazimineThe serum concentration of Fexofenadine can be increased when it is combined with Clofazimine.Approved, Investigational
clomethiazoleThe risk or severity of adverse effects can be increased when clomethiazole is combined with Fexofenadine.Investigational
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Fexofenadine.Approved, Investigational
ClomipramineThe serum concentration of Fexofenadine can be increased when it is combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Clonazepam.Approved, Illicit
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Fexofenadine.Approved
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Fexofenadine.Approved, Nutraceutical
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Fexofenadine.Approved, Illicit
ClotrimazoleThe serum concentration of Fexofenadine can be decreased when it is combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Fexofenadine.Approved
CobicistatThe serum concentration of Fexofenadine can be increased when it is combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Fexofenadine.Approved
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Fexofenadine.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Fexofenadine.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Fexofenadine.Approved
ColforsinThe serum concentration of Fexofenadine can be increased when it is combined with Colforsin.Experimental
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Fexofenadine.Approved
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Fexofenadine.Approved
CyclizineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Fexofenadine.Approved
CyclophosphamideThe serum concentration of Fexofenadine can be increased when it is combined with Cyclophosphamide.Approved, Investigational
CyclosporineThe serum concentration of Fexofenadine can be decreased when it is combined with Cyclosporine.Approved, Investigational, Vet Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Cyproheptadine is combined with Fexofenadine.Approved
Dabigatran etexilateThe serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Fexofenadine.Approved
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Fexofenadine.Approved
DaclatasvirThe serum concentration of Fexofenadine can be increased when it is combined with Daclatasvir.Approved
DactinomycinThe serum concentration of Fexofenadine can be increased when it is combined with Dactinomycin.Approved
DantroleneThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Dantrolene.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Fexofenadine.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Fexofenadine.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Dapoxetine.Investigational
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Fexofenadine.Approved, Investigational
DaunorubicinThe serum concentration of Fexofenadine can be decreased when it is combined with Daunorubicin.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Fexofenadine.Approved
deramciclaneThe risk or severity of adverse effects can be increased when deramciclane is combined with Fexofenadine.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Fexofenadine.Approved
DesipramineThe serum concentration of Fexofenadine can be increased when it is combined with Desipramine.Approved
DesloratadineThe serum concentration of Fexofenadine can be increased when it is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Detomidine is combined with Fexofenadine.Vet Approved
DexamethasoneThe serum concentration of Fexofenadine can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Fexofenadine.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Fexofenadine.Approved, Vet Approved
DextroamphetamineDextroamphetamine may decrease the sedative activities of Fexofenadine.Approved, Illicit
DextromethorphanThe serum concentration of Fexofenadine can be increased when it is combined with Dextromethorphan.Approved
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Fexofenadine.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Fexofenadine.Approved, Illicit, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Fexofenadine.Approved
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Fexofenadine.Approved, Illicit, Vet Approved
DiclofenacThe serum concentration of Fexofenadine can be increased when it is combined with Diclofenac.Approved, Vet Approved
DiethylpropionDiethylpropion may decrease the sedative activities of Fexofenadine.Approved, Illicit
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Fexofenadine.Approved
DifenoxinThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Difenoxin.Approved, Illicit
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Fexofenadine.Approved
DigoxinThe serum concentration of Fexofenadine can be decreased when it is combined with Digoxin.Approved
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Fexofenadine.Approved, Illicit
DihydroergotamineThe serum concentration of Fexofenadine can be increased when it is combined with Dihydroergotamine.Approved
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Fexofenadine.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Fexofenadine.Experimental, Illicit
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Fexofenadine.Illicit
DiltiazemThe serum concentration of Fexofenadine can be increased when it is combined with Diltiazem.Approved
DimenhydrinateThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Dimenhydrinate.Approved
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Fexofenadine.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Fexofenadine.Approved, Illicit
DipyridamoleThe serum concentration of Fexofenadine can be increased when it is combined with Dipyridamole.Approved
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Fexofenadine.Approved, Investigational
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Fexofenadine.Approved, Investigational, Vet Approved
DoramectinThe risk or severity of adverse effects can be increased when Doramectin is combined with Fexofenadine.Vet Approved
DoxazosinThe serum concentration of Fexofenadine can be increased when it is combined with Doxazosin.Approved
DoxepinThe serum concentration of Fexofenadine can be increased when it is combined with Doxepin.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Fexofenadine.Approved, Investigational
DoxorubicinThe serum concentration of Fexofenadine can be decreased when it is combined with Doxorubicin.Approved, Investigational
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Fexofenadine.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.Approved, Illicit
DronedaroneThe serum concentration of Fexofenadine can be increased when it is combined with Dronedarone.Approved
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Fexofenadine.Experimental, Illicit
DuloxetineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Fexofenadine.Approved
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Fexofenadine.Experimental, Illicit
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when ECGONINE METHYL ESTER is combined with Fexofenadine.Experimental
EcopipamThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Ecopipam.Investigational
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Fexofenadine.Approved
EfavirenzThe risk or severity of adverse effects can be increased when Efavirenz is combined with Fexofenadine.Approved, Investigational
ElbasvirThe serum concentration of Fexofenadine can be increased when it is combined with Elbasvir.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Fexofenadine.Approved, Investigational
EnalaprilThe serum concentration of Fexofenadine can be increased when it is combined with Enalapril.Approved, Vet Approved
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Fexofenadine.Approved, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Entacapone is combined with Fexofenadine.Approved, Investigational
EnzalutamideThe serum concentration of Fexofenadine can be increased when it is combined with Enzalutamide.Approved
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Fexofenadine.Approved, Investigational
ErgonovineThe serum concentration of Fexofenadine can be increased when it is combined with Ergonovine.Approved
ErgotamineThe serum concentration of Fexofenadine can be increased when it is combined with Ergotamine.Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Fexofenadine.Approved, Investigational
ErythromycinThe serum concentration of Fexofenadine can be decreased when it is combined with Erythromycin.Approved, Vet Approved
ErythromycinThe serum concentration of Fexofenadine can be increased when it is combined with Erythromycin.Approved, Vet Approved
EscitalopramThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Escitalopram.Approved, Investigational
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Fexofenadine.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Fexofenadine.Approved, Investigational, Vet Approved
EstramustineThe serum concentration of Fexofenadine can be increased when it is combined with Estramustine.Approved
EstriolThe serum concentration of Fexofenadine can be decreased when it is combined with Estriol.Approved, Vet Approved
EstroneThe serum concentration of Fexofenadine can be decreased when it is combined with Estrone.Approved
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Fexofenadine.Approved
EthanolFexofenadine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Fexofenadine.Approved, Illicit, Withdrawn
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Fexofenadine.Approved
EthosuximideThe risk or severity of adverse effects can be increased when Ethosuximide is combined with Fexofenadine.Approved
EthotoinThe risk or severity of adverse effects can be increased when Ethotoin is combined with Fexofenadine.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Fexofenadine.Withdrawn
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Fexofenadine.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Fexofenadine.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Etidocaine is combined with Fexofenadine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Fexofenadine.Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Etizolam is combined with Fexofenadine.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Fexofenadine.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Etoperidone.Approved
EtoposideThe serum concentration of Fexofenadine can be increased when it is combined with Etoposide.Approved
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Fexofenadine.Illicit, Vet Approved
EtravirineThe serum concentration of Fexofenadine can be increased when it is combined with Etravirine.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Fexofenadine.Approved
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Fexofenadine.Approved
EzogabineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Felbamate is combined with Fexofenadine.Approved
FelodipineThe serum concentration of Fexofenadine can be increased when it is combined with Felodipine.Approved, Investigational
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Fexofenadine.Approved, Illicit, Withdrawn
FentanylThe serum concentration of Fexofenadine can be increased when it is combined with Fentanyl.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Fexofenadine.Approved
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Fexofenadine.Approved
FlibanserinThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Flibanserin.Approved
FluconazoleThe serum concentration of Fexofenadine can be increased when it is combined with Fluconazole.Approved
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Fexofenadine.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Fexofenadine.Approved, Illicit
FluoxetineThe serum concentration of Fexofenadine can be increased when it is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe serum concentration of Fexofenadine can be increased when it is combined with Flupentixol.Approved, Withdrawn
FluphenazineThe serum concentration of Fexofenadine can be increased when it is combined with Fluphenazine.Approved
FlurazepamThe serum concentration of Fexofenadine can be increased when it is combined with Flurazepam.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Fluspirilene is combined with Fexofenadine.Approved
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Fexofenadine.Approved
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Fluticasone Propionate is combined with Fexofenadine.Approved
FluvoxamineThe serum concentration of Fexofenadine can be increased when it is combined with Fluvoxamine.Approved, Investigational
FosphenytoinThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Fospropofol is combined with Fexofenadine.Approved, Illicit
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Fexofenadine.Approved, Investigational
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Fexofenadine is combined with gabapentin enacarbil.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Fexofenadine.Approved, Illicit
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Fexofenadine.Approved, Investigational
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Fexofenadine.Approved
GenisteinThe serum concentration of Fexofenadine can be increased when it is combined with Genistein.Investigational
GepironeThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Fexofenadine.Approved, Illicit
GlyburideThe serum concentration of Fexofenadine can be increased when it is combined with Glyburide.Approved
GlycerolThe serum concentration of Fexofenadine can be increased when it is combined with Glycerol.Experimental
Gramicidin DThe serum concentration of Fexofenadine can be increased when it is combined with Gramicidin D.Approved
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Fexofenadine.Approved
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Fexofenadine.Withdrawn
GuanfacineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Fexofenadine.Approved, Illicit, Withdrawn
HaloperidolThe serum concentration of Fexofenadine can be increased when it is combined with Haloperidol.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Fexofenadine.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Fexofenadine.Approved, Illicit
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Fexofenadine.Approved
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Fexofenadine.Approved, Investigational
HydrocodoneFexofenadine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydrocortisoneThe serum concentration of Fexofenadine can be increased when it is combined with Hydrocortisone.Approved, Vet Approved
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Fexofenadine.Approved, Illicit
Hydroxyamphetamine hydrobromideHydroxyamphetamine hydrobromide may decrease the sedative activities of Fexofenadine.Approved
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.Approved
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Fexofenadine.Approved
IdelalisibThe serum concentration of Idelalisib can be increased when it is combined with Fexofenadine.Approved
IloperidoneThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Iloperidone.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Fexofenadine.Approved
ImipramineThe serum concentration of Fexofenadine can be increased when it is combined with Imipramine.Approved
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Fexofenadine.Approved
IndalpineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Indalpine.Investigational, Withdrawn
IndinavirThe serum concentration of Fexofenadine can be decreased when it is combined with Indinavir.Approved
IndomethacinThe serum concentration of Fexofenadine can be increased when it is combined with Indomethacin.Approved, Investigational
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Fexofenadine.Approved, Investigational
IsavuconazoniumThe serum concentration of Fexofenadine can be increased when it is combined with Isavuconazonium.Approved, Investigational
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Fexofenadine.Approved, Vet Approved
ItraconazoleThe serum concentration of Fexofenadine can be increased when it is combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Fexofenadine can be increased when it is combined with Ivacaftor.Approved
IvermectinThe serum concentration of Fexofenadine can be increased when it is combined with Ivermectin.Approved, Vet Approved
KetamineThe serum concentration of Fexofenadine can be increased when it is combined with Ketamine.Approved, Vet Approved
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Fexofenadine.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Ketobemidone is combined with Fexofenadine.Approved
KetoconazoleThe serum concentration of Fexofenadine can be increased when it is combined with Ketoconazole.Approved, Investigational
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Fexofenadine.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Fexofenadine.Approved, Investigational
LansoprazoleThe serum concentration of Fexofenadine can be increased when it is combined with Lansoprazole.Approved, Investigational
LapatinibThe serum concentration of Fexofenadine can be increased when it is combined with Lapatinib.Approved, Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Fexofenadine.Approved
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Fexofenadine.Approved
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Fexofenadine.Approved
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Fexofenadine.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Fexofenadine.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Levodopa.Approved
LevofloxacinThe serum concentration of Fexofenadine can be increased when it is combined with Levofloxacin.Approved, Investigational
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Fexofenadine.Approved
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Fexofenadine.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Fexofenadine.Approved
LevothyroxineThe serum concentration of Fexofenadine can be decreased when it is combined with Levothyroxine.Approved
LidocaineThe serum concentration of Fexofenadine can be increased when it is combined with Lidocaine.Approved, Vet Approved
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Fexofenadine.Approved
LiothyronineThe serum concentration of Fexofenadine can be decreased when it is combined with Liothyronine.Approved, Vet Approved
LiotrixThe serum concentration of Fexofenadine can be decreased when it is combined with Liotrix.Approved
LisdexamfetamineLisdexamfetamine may decrease the sedative activities of Fexofenadine.Approved, Investigational
LisinoprilThe serum concentration of Fexofenadine can be increased when it is combined with Lisinopril.Approved, Investigational
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Fexofenadine.Approved
LofentanilThe risk or severity of adverse effects can be increased when Lofentanil is combined with Fexofenadine.Illicit
LomitapideThe serum concentration of Fexofenadine can be increased when it is combined with Lomitapide.Approved
LoperamideThe serum concentration of Fexofenadine can be increased when it is combined with Loperamide.Approved
LopinavirThe serum concentration of Fexofenadine can be increased when it is combined with Lopinavir.Approved
LoratadineThe serum concentration of Fexofenadine can be increased when it is combined with Loratadine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Fexofenadine.Approved
LosartanThe serum concentration of Fexofenadine can be increased when it is combined with Losartan.Approved
LovastatinThe serum concentration of Fexofenadine can be increased when it is combined with Lovastatin.Approved, Investigational
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Fexofenadine.Approved
Lu AA21004The risk or severity of adverse effects can be increased when Lu AA21004 is combined with Fexofenadine.Investigational
LumacaftorThe serum concentration of Fexofenadine can be decreased when it is combined with Lumacaftor.Approved
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with Fexofenadine.Approved
MagaldrateThe serum concentration of Fexofenadine can be decreased when it is combined with Magaldrate.Withdrawn
Magnesium carbonateThe serum concentration of Fexofenadine can be decreased when it is combined with Magnesium carbonate.Approved
Magnesium hydroxideThe serum concentration of Fexofenadine can be decreased when it is combined with Magnesium hydroxide.Approved
Magnesium oxideThe serum concentration of Fexofenadine can be decreased when it is combined with Magnesium oxide.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.Approved, Vet Approved
Magnesium TrisilicateThe serum concentration of Fexofenadine can be decreased when it is combined with Magnesium Trisilicate.Approved
MannitolThe serum concentration of Mannitol can be increased when it is combined with Fexofenadine.Approved, Investigational
MaprotilineThe serum concentration of Fexofenadine can be increased when it is combined with Maprotiline.Approved
MebendazoleThe serum concentration of Fexofenadine can be increased when it is combined with Mebendazole.Approved, Vet Approved
MeclizineThe risk or severity of adverse effects can be increased when Meclizine is combined with Fexofenadine.Approved
MedetomidineThe risk or severity of adverse effects can be increased when Medetomidine is combined with Fexofenadine.Vet Approved
MefloquineThe serum concentration of Fexofenadine can be increased when it is combined with Mefloquine.Approved
Megestrol acetateThe serum concentration of Fexofenadine can be increased when it is combined with Megestrol acetate.Approved, Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Fexofenadine.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Melperone is combined with Fexofenadine.Approved
MephedroneMephedrone may decrease the sedative activities of Fexofenadine.Investigational
MephentermineMephentermine may decrease the sedative activities of Fexofenadine.Approved
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Fexofenadine.Approved, Vet Approved
MeprobamateThe serum concentration of Fexofenadine can be increased when it is combined with Meprobamate.Approved, Illicit
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Fexofenadine.Approved
MetaxaloneThe risk or severity of adverse effects can be increased when Metaxalone is combined with Fexofenadine.Approved
MethadoneThe serum concentration of Fexofenadine can be increased when it is combined with Methadone.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Fexofenadine.Approved, Illicit
MethamphetamineMethamphetamine may decrease the sedative activities of Fexofenadine.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Fexofenadine.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Fexofenadine.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Methocarbamol is combined with Fexofenadine.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Fexofenadine.Approved
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Fexofenadine.Approved
MethotrimeprazineFexofenadine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Fexofenadine.Approved, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Methsuximide.Approved
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Fexofenadine.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Fexofenadine.Approved, Vet Approved
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Fexofenadine.Approved, Investigational
MetyrosineFexofenadine may increase the sedative activities of Metyrosine.Approved
MibefradilThe serum concentration of Fexofenadine can be increased when it is combined with Mibefradil.Withdrawn
MiconazoleThe serum concentration of Fexofenadine can be increased when it is combined with Miconazole.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Fexofenadine can be decreased when it is combined with Midazolam.Approved, Illicit
MifepristoneThe serum concentration of Fexofenadine can be decreased when it is combined with Mifepristone.Approved, Investigational
MilnacipranThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Milnacipran.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.Approved, Investigational
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Fexofenadine.Approved
MirtazapineFexofenadine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MitomycinThe serum concentration of Fexofenadine can be increased when it is combined with Mitomycin.Approved
MitoxantroneThe serum concentration of Fexofenadine can be decreased when it is combined with Mitoxantrone.Approved, Investigational
MMDAMMDA may decrease the sedative activities of Fexofenadine.Experimental, Illicit
MolindoneThe risk or severity of adverse effects can be increased when Molindone is combined with Fexofenadine.Approved
MorphineThe serum concentration of Fexofenadine can be increased when it is combined with Morphine.Approved, Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Fexofenadine.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.Approved, Investigational
NadololThe serum concentration of Nadolol can be increased when it is combined with Fexofenadine.Approved
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Fexofenadine.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Fexofenadine.Approved
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Fexofenadine.Approved, Vet Approved
NaltrexoneThe serum concentration of Fexofenadine can be increased when it is combined with Naltrexone.Approved, Investigational, Vet Approved
NaringeninThe serum concentration of Fexofenadine can be increased when it is combined with Naringenin.Experimental
NefazodoneThe serum concentration of Fexofenadine can be decreased when it is combined with Nefazodone.Approved, Withdrawn
NelfinavirThe serum concentration of Fexofenadine can be decreased when it is combined with Nelfinavir.Approved
NeostigmineThe serum concentration of Fexofenadine can be increased when it is combined with Neostigmine.Approved, Vet Approved
NicardipineThe serum concentration of Fexofenadine can be increased when it is combined with Nicardipine.Approved
NifedipineThe serum concentration of Fexofenadine can be decreased when it is combined with Nifedipine.Approved
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Fexofenadine.Approved, Investigational
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Fexofenadine.Approved
NisoldipineThe serum concentration of Fexofenadine can be increased when it is combined with Nisoldipine.Approved
NitrazepamThe serum concentration of Fexofenadine can be increased when it is combined with Nitrazepam.Approved
NitrendipineThe serum concentration of Fexofenadine can be increased when it is combined with Nitrendipine.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Fexofenadine.Approved, Vet Approved
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Fexofenadine.Approved
NorethisteroneThe serum concentration of Fexofenadine can be decreased when it is combined with Norethisterone.Approved
NormethadoneThe risk or severity of adverse effects can be increased when Normethadone is combined with Fexofenadine.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Nortriptyline is combined with Fexofenadine.Approved
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Fexofenadine.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Olopatadine is combined with Fexofenadine.Approved
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Fexofenadine.Approved
OmeprazoleThe serum concentration of Fexofenadine can be increased when it is combined with Omeprazole.Approved, Investigational, Vet Approved
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Fexofenadine.Approved
OpiumThe risk or severity of adverse effects can be increased when Opium is combined with Fexofenadine.Approved, Illicit
OrphenadrineFexofenadine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Osanetant is combined with Fexofenadine.Investigational
OsimertinibThe serum concentration of Osimertinib can be increased when it is combined with Fexofenadine.Approved
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Fexofenadine.Approved
OxetacaineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Oxetacaine.Investigational
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Fexofenadine.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Fexofenadine.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Fexofenadine.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Fexofenadine.Approved, Investigational, Vet Approved
P-NitrophenolThe serum concentration of Fexofenadine can be increased when it is combined with P-Nitrophenol.Experimental
PaclitaxelThe serum concentration of Fexofenadine can be increased when it is combined with Paclitaxel.Approved, Vet Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Fexofenadine.Approved
Palmitic AcidThe serum concentration of Fexofenadine can be increased when it is combined with Palmitic Acid.Experimental
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Fexofenadine.Approved, Investigational
PantoprazoleThe serum concentration of Fexofenadine can be increased when it is combined with Pantoprazole.Approved
ParaldehydeFexofenadine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ParoxetineThe serum concentration of Fexofenadine can be increased when it is combined with Paroxetine.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Fexofenadine.Approved
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Fexofenadine.Approved, Vet Approved
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Fexofenadine.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.Approved
PerazineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Perazine.Investigational
PerindoprilThe serum concentration of Fexofenadine can be increased when it is combined with Perindopril.Approved
PerospironeThe risk or severity of adverse effects can be increased when Perospirone is combined with Fexofenadine.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Fexofenadine.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Fexofenadine.Approved
PhenobarbitalThe serum concentration of Fexofenadine can be decreased when it is combined with Phenobarbital.Approved
PhenoxyethanolThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Fexofenadine.Approved
PhenterminePhentermine may decrease the sedative activities of Fexofenadine.Approved, Illicit
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Fexofenadine.Approved, Vet Approved
PimozideThe serum concentration of Fexofenadine can be increased when it is combined with Pimozide.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Pipamperone is combined with Fexofenadine.Approved
PipotiazineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Pipotiazine.Approved
PiritramideThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Piritramide.Investigational
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Fexofenadine.Approved
PizotifenThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Pizotifen.Approved
Platelet Activating FactorThe serum concentration of Fexofenadine can be decreased when it is combined with Platelet Activating Factor.Experimental
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Fexofenadine.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Fexofenadine.Approved
PosaconazoleThe serum concentration of Fexofenadine can be increased when it is combined with Posaconazole.Approved, Investigational, Vet Approved
PramipexoleFexofenadine may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Pramocaine is combined with Fexofenadine.Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Fexofenadine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with Fexofenadine.Approved, Illicit
PrazosinThe serum concentration of Fexofenadine can be increased when it is combined with Prazosin.Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Fexofenadine.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Fexofenadine.Approved, Vet Approved
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Fexofenadine.Approved, Illicit, Investigational
PregnanoloneThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Pregnanolone.Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Fexofenadine.Approved
PrimidoneThe risk or severity of adverse effects can be increased when Primidone is combined with Fexofenadine.Approved, Vet Approved
ProbenecidThe serum concentration of Fexofenadine can be increased when it is combined with Probenecid.Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Fexofenadine.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Fexofenadine.Approved, Vet Approved
ProgesteroneThe serum concentration of Fexofenadine can be decreased when it is combined with Progesterone.Approved, Vet Approved
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Fexofenadine.Approved, Vet Approved
PromethazineThe serum concentration of Fexofenadine can be increased when it is combined with Promethazine.Approved
PropafenoneThe serum concentration of Fexofenadine can be increased when it is combined with Propafenone.Approved
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Fexofenadine.Approved, Vet Approved
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Fexofenadine.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Fexofenadine.Approved
PropranololThe serum concentration of Propranolol can be increased when it is combined with Fexofenadine.Approved, Investigational
ProtriptylineThe serum concentration of Fexofenadine can be increased when it is combined with Protriptyline.Approved
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Fexofenadine.Approved
PSD502The risk or severity of adverse effects can be increased when PSD502 is combined with Fexofenadine.Investigational
PseudoephedrinePseudoephedrine may decrease the sedative activities of Fexofenadine.Approved
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Fexofenadine.Approved, Illicit
QuercetinThe serum concentration of Fexofenadine can be increased when it is combined with Quercetin.Experimental
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Fexofenadine.Approved
QuinacrineThe serum concentration of Fexofenadine can be increased when it is combined with Quinacrine.Approved
QuinidineThe serum concentration of Fexofenadine can be increased when it is combined with Quinidine.Approved
QuinineThe serum concentration of Fexofenadine can be increased when it is combined with Quinine.Approved
RacloprideThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Ramelteon.Approved, Investigational
RanitidineThe serum concentration of Fexofenadine can be increased when it is combined with Ranitidine.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Fexofenadine.Approved, Investigational
ReboxetineThe serum concentration of Fexofenadine can be increased when it is combined with Reboxetine.Approved, Investigational
RegorafenibThe serum concentration of Fexofenadine can be increased when it is combined with Regorafenib.Approved
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Fexofenadine.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Fexofenadine.Approved, Withdrawn
ReserpineThe serum concentration of Fexofenadine can be decreased when it is combined with Reserpine.Approved
RifampicinThe serum concentration of Fexofenadine can be decreased when it is combined with Rifampicin.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Fexofenadine.Approved, Investigational
RilpivirineThe serum concentration of Fexofenadine can be increased when it is combined with Rilpivirine.Approved
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Fexofenadine.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Ritanserin.Investigational
RitobegronRitobegron may decrease the sedative activities of Fexofenadine.Investigational
RitonavirThe serum concentration of Fexofenadine can be decreased when it is combined with Ritonavir.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Fexofenadine.Approved
RolapitantThe serum concentration of Fexofenadine can be increased when it is combined with Rolapitant.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Fexofenadine.Approved, Investigational
RomifidineThe risk or severity of adverse effects can be increased when Romifidine is combined with Fexofenadine.Vet Approved
RopiniroleFexofenadine may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Fexofenadine.Approved
RotigotineFexofenadine may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Fexofenadine.Approved
S-EthylisothioureaThe risk or severity of adverse effects can be increased when S-Ethylisothiourea is combined with Fexofenadine.Experimental
Sage 547The risk or severity of adverse effects can be increased when Fexofenadine is combined with Sage 547.Investigational
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Fexofenadine.Approved, Vet Approved
SaquinavirThe serum concentration of Fexofenadine can be decreased when it is combined with Saquinavir.Approved, Investigational
ScopolamineThe serum concentration of Fexofenadine can be increased when it is combined with Scopolamine.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Fexofenadine.Approved, Vet Approved
SelegilineThe serum concentration of Fexofenadine can be increased when it is combined with Selegiline.Approved, Investigational, Vet Approved
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Fexofenadine.Approved
SertindoleThe risk or severity of adverse effects can be increased when Sertindole is combined with Fexofenadine.Approved, Withdrawn
SertralineThe serum concentration of Fexofenadine can be increased when it is combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Fexofenadine.Approved, Vet Approved
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Fexofenadine.Approved
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Fexofenadine.Approved
SimvastatinThe serum concentration of Fexofenadine can be increased when it is combined with Simvastatin.Approved
SirolimusThe serum concentration of Fexofenadine can be decreased when it is combined with Sirolimus.Approved, Investigational
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Fexofenadine.Approved, Investigational
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.Approved
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Fexofenadine.Approved
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Fexofenadine.Approved, Investigational
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Fexofenadine.Approved
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Fexofenadine.Experimental
SpironolactoneThe serum concentration of Fexofenadine can be increased when it is combined with Spironolactone.Approved
St. John's WortThe serum concentration of Fexofenadine can be decreased when it is combined with St. John's Wort.Nutraceutical
StaurosporineThe serum concentration of Fexofenadine can be increased when it is combined with Staurosporine.Experimental
StiripentolThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Stiripentol.Approved
StreptozocinThe serum concentration of Fexofenadine can be decreased when it is combined with Streptozocin.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Fexofenadine.Approved, Investigational
SulfinpyrazoneThe serum concentration of Fexofenadine can be increased when it is combined with Sulfinpyrazone.Approved
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Fexofenadine.Approved
SumatriptanThe serum concentration of Fexofenadine can be increased when it is combined with Sumatriptan.Approved, Investigational
SunitinibThe serum concentration of Fexofenadine can be increased when it is combined with Sunitinib.Approved, Investigational
SuvorexantFexofenadine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TacrineThe serum concentration of Fexofenadine can be increased when it is combined with Tacrine.Withdrawn
TacrolimusThe serum concentration of Fexofenadine can be decreased when it is combined with Tacrolimus.Approved, Investigational
TamoxifenThe serum concentration of Fexofenadine can be decreased when it is combined with Tamoxifen.Approved
TandospironeThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Tasimelteon.Approved
Taurocholic AcidThe serum concentration of Fexofenadine can be increased when it is combined with Taurocholic Acid.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Fexofenadine.Approved
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Fexofenadine.Approved
TelmisartanThe serum concentration of Fexofenadine can be increased when it is combined with Telmisartan.Approved, Investigational
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Fexofenadine.Approved
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Fexofenadine.Approved
TerazosinThe serum concentration of Fexofenadine can be increased when it is combined with Terazosin.Approved
TerfenadineThe serum concentration of Fexofenadine can be increased when it is combined with Terfenadine.Withdrawn
TesmilifeneThe serum concentration of Fexofenadine can be decreased when it is combined with Tesmilifene.Investigational
TestosteroneThe serum concentration of Fexofenadine can be increased when it is combined with Testosterone.Approved, Investigational
TetrabenazineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Tetracaine is combined with Fexofenadine.Approved, Vet Approved
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Fexofenadine.Investigational
ThalidomideFexofenadine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Fexofenadine.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Fexofenadine.Approved, Vet Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Fexofenadine.Approved
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Fexofenadine.Approved
TiagabineThe risk or severity of adverse effects can be increased when Tiagabine is combined with Fexofenadine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Tiapride.Investigational
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Fexofenadine.Approved
TiletamineThe risk or severity of adverse effects can be increased when Tiletamine is combined with Fexofenadine.Vet Approved
TimololThe serum concentration of Timolol can be increased when it is combined with Fexofenadine.Approved
TizanidineThe risk or severity of adverse effects can be increased when Tizanidine is combined with Fexofenadine.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Fexofenadine.Approved, Withdrawn
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Fexofenadine.Approved
TopiramateThe risk or severity of adverse effects can be increased when Topiramate is combined with Fexofenadine.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Fexofenadine.Approved, Investigational
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Fexofenadine.Approved, Investigational
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Fexofenadine.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with Fexofenadine.Experimental
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Fexofenadine.Approved
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Fexofenadine.Approved
TrazodoneThe serum concentration of Fexofenadine can be decreased when it is combined with Trazodone.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Fexofenadine.Approved
TrifluoperazineThe serum concentration of Fexofenadine can be increased when it is combined with Trifluoperazine.Approved
TriflupromazineThe serum concentration of Fexofenadine can be increased when it is combined with Triflupromazine.Approved, Vet Approved
TrimethoprimThe serum concentration of Fexofenadine can be decreased when it is combined with Trimethoprim.Approved, Vet Approved
TrimipramineThe serum concentration of Fexofenadine can be increased when it is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Triprolidine is combined with Fexofenadine.Approved
TroleandomycinThe serum concentration of Fexofenadine can be increased when it is combined with Troleandomycin.Approved
Uc1010The risk or severity of adverse effects can be increased when Fexofenadine is combined with Uc1010.Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Fexofenadine.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Fexofenadine.Approved
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Fexofenadine.Approved, Investigational
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Fexofenadine.Approved
VenetoclaxThe serum concentration of Venetoclax can be increased when it is combined with Fexofenadine.Approved
VenlafaxineThe serum concentration of Fexofenadine can be increased when it is combined with Venlafaxine.Approved
VerapamilThe bioavailability of Fexofenadine can be increased when combined with Verapamil.Approved
VigabatrinThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Vigabatrin.Approved
VinblastineThe serum concentration of Fexofenadine can be decreased when it is combined with Vinblastine.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Fexofenadine.Approved, Investigational
VincristineThe serum concentration of Fexofenadine can be decreased when it is combined with Vincristine.Approved, Investigational
VinorelbineThe serum concentration of Fexofenadine can be increased when it is combined with Vinorelbine.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Fexofenadine.Approved
VortioxetineThe risk or severity of adverse effects can be increased when Vortioxetine is combined with Fexofenadine.Approved
XylazineThe risk or severity of adverse effects can be increased when Xylazine is combined with Fexofenadine.Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Fexofenadine.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Ziconotide.Approved
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Fexofenadine.Approved
ZimelidineThe serum concentration of Fexofenadine can be increased when it is combined with Zimelidine.Withdrawn
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Fexofenadine.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Zolazepam is combined with Fexofenadine.Vet Approved
ZolpidemFexofenadine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Zonisamide is combined with Fexofenadine.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Fexofenadine.Approved
ZotepineThe risk or severity of adverse effects can be increased when Zotepine is combined with Fexofenadine.Approved
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Fexofenadine.Approved, Investigational
Food Interactions
  • Grapefruit and grapefruit juice should be avoided throughout treatment as grapefruit can significantly decrease serum levels of this product.
  • Take without regard to meals.
References
Synthesis Reference

Federico Milla, “Processes for the production of fexofenadine.” U.S. Patent US20030166682, issued September 04, 2003.

US20030166682
General References
  1. Smith SM, Gums JG: Fexofenadine: biochemical, pharmacokinetic and pharmacodynamic properties and its unique role in allergic disorders. Expert Opin Drug Metab Toxicol. 2009 Jul;5(7):813-22. doi: 10.1517/17425250903044967. [PubMed:19545214 ]
  2. Bachert C: A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis. Clin Ther. 2009 May;31(5):921-44. doi: 10.1016/j.clinthera.2009.05.017. [PubMed:19539095 ]
  3. Markham A, Wagstaff AJ: Fexofenadine. Drugs. 1998 Feb;55(2):269-74; discussion 275-6. [PubMed:9506246 ]
  4. Golightly LK, Greos LS: Second-generation antihistamines: actions and efficacy in the management of allergic disorders. Drugs. 2005;65(3):341-84. [PubMed:15669879 ]
  5. Molimard M, Diquet B, Benedetti MS: Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans. Fundam Clin Pharmacol. 2004 Aug;18(4):399-411. [PubMed:15312146 ]
External Links
ATC CodesR06AX26
AHFS Codes
  • 04:08.00
PDB EntriesNot Available
FDA labelDownload (43.7 KB)
MSDSNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.7881
Blood Brain Barrier-0.8574
Caco-2 permeable+0.5
P-glycoprotein substrateSubstrate0.8641
P-glycoprotein inhibitor INon-inhibitor0.6791
P-glycoprotein inhibitor IINon-inhibitor0.8779
Renal organic cation transporterNon-inhibitor0.5166
CYP450 2C9 substrateNon-substrate0.836
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.6458
CYP450 1A2 substrateNon-inhibitor0.9046
CYP450 2C9 inhibitorNon-inhibitor0.9162
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorNon-inhibitor0.8421
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9756
Ames testNon AMES toxic0.9122
CarcinogenicityNon-carcinogens0.9163
BiodegradationNot ready biodegradable0.8428
Rat acute toxicity2.3481 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8469
hERG inhibition (predictor II)Inhibitor0.6258
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Sanofi aventis us llc
  • Barr laboratories inc
  • Dr reddys laboratories ltd
  • Mylan pharmaceuticals inc
  • Teva pharmaceuticals usa inc
  • Sanofi-Aventis
Packagers
Dosage forms
FormRouteStrength
SuspensionOral6 mg/mL
TabletOral60 mg
TabletOral120 mg
Tablet, coatedOral180 mg/1
Tablet, extended releaseOral
Tablet, film coatedOral
Tablet, orally disintegratingOral30 mg/1
SuspensionOral30 mg/5mL
TabletOral60 mg/1
Tablet, film coatedOral30 mg/1
TabletOral180 mg/1
Tablet, film coated, extended releaseOral
Tablet, film coatedOral60 mg/1
Tablet, film coatedOral180 mg/1
Prices
Unit descriptionCostUnit
Allegra ODT 60 30 mg Dispersible Tablet Box126.0USD box
Allegra-D 24 Hour 180-240 mg 24 Hour tablet5.01USD tablet
Allegra-d 24 hour tablet4.98USD tablet
Allegra 180 mg tablet2.89USD tablet
Allegra-D 12 Hour 60-120 mg 12 Hour tablet2.72USD tablet
Allegra-d 12 hour tablet2.49USD tablet
Fexofenadine hcl 180 mg tablet2.47USD tablet
Allegra odt 30 mg tablet1.98USD tablet
Allegra 60 mg tablet1.64USD tablet
Fexofenadine hcl 60 mg tablet1.43USD tablet
Allegra 30 mg tablet0.81USD tablet
Fexofenadine hcl 30 mg tablet0.71USD tablet
Allegra 30 mg/5ml Suspension0.25USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2134211 No1999-06-292013-04-06Canada
CA2301267 No2004-07-132018-07-21Canada
US5178878 No1993-01-122010-01-12Us
US5738872 Yes1995-08-282015-08-28Us
US5855912 Yes1995-08-282015-08-28Us
US5932247 Yes1995-08-282015-08-28Us
US6037353 Yes1997-09-142017-09-14Us
US6039974 No1998-07-312018-07-31Us
US6113942 Yes1995-08-282015-08-28Us
US6613357 No2000-12-252020-12-25Us
US6723348 No2001-11-262021-11-26Us
US8933097 No2012-08-162032-08-16Us
USRE39069 No1998-05-292018-05-29Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point142.5 °CPhysProp
water solubilitySlightly solubleNot Available
logP5.6Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00266 mg/mLALOGPS
logP5.02ALOGPS
logP2.94ChemAxon
logS-5.3ALOGPS
pKa (Strongest Acidic)4.04ChemAxon
pKa (Strongest Basic)9.01ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area81 Å2ChemAxon
Rotatable Bond Count10ChemAxon
Refractivity147.98 m3·mol-1ChemAxon
Polarizability57.42 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassDiphenylmethanes
Direct ParentDiphenylmethanes
Alternative Parents
Substituents
  • Diphenylmethane
  • 2-phenylpropanoic-acid
  • Phenylbutylamine
  • Phenylacetate
  • Phenylpropane
  • Aralkylamine
  • Piperidine
  • Tertiary alcohol
  • Tertiary aliphatic amine
  • Tertiary amine
  • Secondary alcohol
  • Azacycle
  • Organoheterocyclic compound
  • Monocarboxylic acid or derivatives
  • Carboxylic acid
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Aromatic alcohol
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Alcohol
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External DescriptorsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Histamine receptor activity
Specific Function:
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Gene Name:
HRH1
Uniprot ID:
P35367
Molecular Weight:
55783.61 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Amon U, Amon S, Gibbs BF: In vitro studies with fexofenadine, a new nonsedating histamine H1 receptor antagonist, on isolated human basophils. Inflamm Res. 2000 Apr;49 Suppl 1:S13-4. [PubMed:10864400 ]
  3. Abbas MN, Abdel Fattah AA, Zahran E: A novel membrane sensor for histamine H1-receptor antagonist "fexofenadine". Anal Sci. 2004 Aug;20(8):1137-42. [PubMed:15352500 ]
  4. Grzelewska-Rzymowska I, Kroczynska-Bednarek J, Pietrzkowicz M: [Effect of fexofenadine--selective antagonist of histamine receptor (H1) on histamine-induced bronchoconstriction]. Pol Merkur Lekarski. 2003 Jan;14(79):43-6. [PubMed:12712828 ]
  5. Tashiro M, Sakurada Y, Iwabuchi K, Mochizuki H, Kato M, Aoki M, Funaki Y, Itoh M, Iwata R, Wong DF, Yanai K: Central effects of fexofenadine and cetirizine: measurement of psychomotor performance, subjective sleepiness, and brain histamine H1-receptor occupancy using 11C-doxepin positron emission tomography. J Clin Pharmacol. 2004 Aug;44(8):890-900. [PubMed:15286093 ]
  6. Cavero I, Mestre M, Guillon JM, Heuillet E, Roach AG: Preclinical in vitro cardiac electrophysiology: a method of predicting arrhythmogenic potential of antihistamines in humans? Drug Saf. 1999;21 Suppl 1:19-31; discussion 81-7. [PubMed:10597865 ]
  7. Devillier P, Roche N, Faisy C: Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine : a comparative review. Clin Pharmacokinet. 2008;47(4):217-30. [PubMed:18336052 ]
  8. Dhanya NB, Thasleem Z, Rai R, Srinivas CR: Comparative efficacy of levocetirizine, desloratidine and fexofenadine by histamine wheal suppression test. Indian J Dermatol Venereol Leprol. 2008 Jul-Aug;74(4):361-3. [PubMed:18797058 ]
  9. Smith SM, Gums JG: Fexofenadine: biochemical, pharmacokinetic and pharmacodynamic properties and its unique role in allergic disorders. Expert Opin Drug Metab Toxicol. 2009 Jul;5(7):813-22. doi: 10.1517/17425250903044967. [PubMed:19545214 ]
  10. Markham A, Wagstaff AJ: Fexofenadine. Drugs. 1998 Feb;55(2):269-74; discussion 275-6. [PubMed:9506246 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. [PubMed:10421612 ]
  2. Soldner A, Christians U, Susanto M, Wacher VJ, Silverman JA, Benet LZ: Grapefruit juice activates P-glycoprotein-mediated drug transport. Pharm Res. 1999 Apr;16(4):478-85. [PubMed:10227700 ]
  3. Petri N, Tannergren C, Rungstad D, Lennernas H: Transport characteristics of fexofenadine in the Caco-2 cell model. Pharm Res. 2004 Aug;21(8):1398-404. [PubMed:15359574 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.
Gene Name:
SLCO2B1
Uniprot ID:
O94956
Molecular Weight:
76709.98 Da
References
  1. Nozawa T, Imai K, Nezu J, Tsuji A, Tamai I: Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human. J Pharmacol Exp Ther. 2004 Feb;308(2):438-45. Epub 2003 Nov 10. [PubMed:14610227 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. [PubMed:10421612 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B1
Uniprot ID:
Q9Y6L6
Molecular Weight:
76447.99 Da
References
  1. Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. [PubMed:10421612 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B3
Uniprot ID:
Q9NPD5
Molecular Weight:
77402.175 Da
References
  1. Shimizu M, Fuse K, Okudaira K, Nishigaki R, Maeda K, Kusuhara H, Sugiyama Y: Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humans. Drug Metab Dispos. 2005 Oct;33(10):1477-81. Epub 2005 Jul 13. [PubMed:16014768 ]
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Drug created on June 13, 2005 07:24 / Updated on December 09, 2016 03:54