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Displaying drugs 2251 - 2275 of 14952 in total

Bethanidine

A guanidinium antihypertensive agent that acts by blocking adrenergic transmission.
Approved

Aminoglutethimide

An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant properties. (From Martindale,...
Approved
Investigational
Matched Description: … Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Hormone Antagonists and Related Agents ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Ethinamate

Ethinamate is a short-acting sedative-hypnotic medication used to treat insomnia. Like many such similar medications, the regular use of ethinamate can result in the development of drug tolerance in a patient. Nevertheless, the medication itself is generally no longer effective after using it for greater than 7 days. Structurally, it...
Approved
Illicit
Withdrawn

Pemoline

In 2005, the Food and Drug Administration (FDA) withdrew approval for pemoline. In March 2005, Abbott Laboratories (Cylert marketer) had discontinued the production of Cylert arguing economic reasons.
Approved
Illicit
Investigational
Withdrawn
Matched Description: … In 2005, the Food and Drug Administration (FDA) withdrew approval for pemoline. …
Matched Categories: … Psychostimulants, Agents Used for ADHD and Nootropics …

Diphenylguanidine

Diphenylguanidine is a complexing agent used in the detection of metals and organic bases and used as an accelerator in the vulcanization of rubber. It is found in some rubber products. It is also a dermatological sensitizer and allergen. Sensitivity to diphenylguanidine may be identified with a clinical patch test.
Approved
Experimental
Matched Description: … Diphenylguanidine is a complexing agent used in the detection of metals and organic bases and used as ... It is also a dermatological sensitizer and allergen. …

Entecavir

Entecavir is an oral antiviral drug used in the treatment of hepatitis B infection. It is marketed under the trade name Baraclude (BMS). Entecavir is a guanine analogue that inhibits all three steps in the viral replication process, and the manufacturer claims that it is more efficacious than previous agents...
Approved
Investigational
Matched Description: … Food and Drug Administration (FDA) in March 2005. ... Entecavir is a guanine analogue that inhibits all three steps in the viral replication process, and the ... manufacturer claims that it is more efficacious than previous agents used to treat hepatitis B (lamivudine and …
Matched Categories: … Nucleosides and Nucleotides ... Nucleoside and Nucleotide Reverse Transcriptase Inhibitors …

Hypromellose

Hypromellose, or hydroxypropyl methylcellulose (HPMC) , is a semisynthetic, inert, and viscoelastic polymer that forms a colloid solution when dissolved in water. It acts as a thickening agent, coating polymer, bioadhesive, solubility enhancer in solid dispersions, and binder in the process of granulation and in modified release formulations . It...
Approved
Matched Description: … binder in the process of granulation and in modified release formulations [A24840]. ... Hypromellose, or hydroxypropyl methylcellulose (HPMC) [L1812], is a semisynthetic, inert, and viscoelastic ... acts as a thickening agent, coating polymer, bioadhesive, solubility enhancer in solid dispersions, and …
Matched Mixtures name: … Rohto Sun and Sport …

Lercanidipine

Lercanidipine is a calcium channel blocker of the dihydropyridine class. It is sold under various commercial names including Zanidip.
Approved
Investigational
Matched Categories: … valsartan and lercanidipine ... enalapril and lercanidipine ... ACE Inhibitors and Calcium Channel Blockers ... Calcium-Regulating Hormones and Agents ... Angiotensin II receptor blockers (ARBs) and calcium channel blockers …

Mephenytoin

Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subunit alpha. Cytochrome P450 2C19, Cytochrome...
Approved
Investigational
Withdrawn
Matched Description: … Mephenytoin and oxazolidinedione derivatives are associated with higher incidences of blood dyscrasias ... Cytochrome P450 2C19, Cytochrome P450 2C8, Cytochrome P450 2C9, Cytochrome P450 2B6, Cytochrome P450 1A2, and …

Selexipag

Selexipag was approved by the United States FDA on December 22, 2015 for the treatment of pulmonary arterial hypertension (PAH) to delay disease progression and reduce risk of hospitalization. PAH is a relatively rare disease with usually a poor prognosis requiring more treatment options to prolong long-term outcomes. Marketed by...
Approved
Matched Description: … December 22, 2015 for the treatment of pulmonary arterial hypertension (PAH) to delay disease progression and ... Marketed by Actelion Pharmaceuticals under brand name Uptravi, selexipag and its active metabolite, ACT ... act as agonists of the prostacyclin receptor to increase vasodilation in the pulmonary circulation and …
Matched Categories: … Blood and Blood Forming Organs …

Glymidine

Glycodiazine is used with diet to lower blood glucose by increasing the secretion of insulin from pancreas and increasing the sensitivity of peripheral tissues to insulin. The mechanism of action of glycodiazine in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta...
Approved
Investigational
Matched Description: … Glycodiazine is used with diet to lower blood glucose by increasing the secretion of insulin from pancreas and ... appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells, and ... ATP-sensitive potassium channel receptors on the pancreatic cell surface, reducing potassium conductance and …
Matched Categories: … Alimentary Tract and Metabolism ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Phenytoin

Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for several other indications such as...
Approved
Vet approved
Matched Description: … Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one ... [A189219,A35884] Both parenteral and oral formulations of phenytoin are available on the market. ... has also been investigated for several other indications such as bipolar disorder, retina protection, and …
Matched Categories: … Phenytoin and Prodrugs ... Metabolic Side Effects of Drugs and Substances …

Nimesulide

Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old. Due to concerns about the risk of hepatotoxicity, nimesulide has...
Approved
Investigational
Withdrawn
Matched Description: … primary dysmenorrhoea in adolescents and adults above 12 years old. ... Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and ... Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis and …
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Topical Products for Joint and Muscular Pain ... Antiinflammatory and Antirheumatic Products, Non-Steroids …

Sugammadex

Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery. Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary paralysis and are especially useful for general anesthesia, ventilation, or tracheal intubation that patients may require...
Approved
Matched Iupac: … 36.2.2.2³,⁶.2⁸,¹¹.2¹³,¹⁶.2¹⁸,²¹.2²³,²⁶.2²⁸,³¹.2³³,³⁶]hexapentacontan-5-yl]methyl}sulfanyl)propanoic acid …
Matched Description: … Sugammadex (brand name Bridion) is marketed by Merck Sharp and Dohme, and was approved by the United ... relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and ... Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary …

Cyclopenthiazide

Cyclopenthiazide is a thiazide diuretic with antihypertensive properties. In a double blind, randomized crossover study, cyclopenthiazide was effective in reducing diastolic blood pressure in mildly hypertensive non-insulin dependent diabetic patients . It is a positive allosteric modulator at AMPA-A receptors .
Approved
Matched Categories: … cyclopenthiazide and potassium ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics ... cyclopenthiazide and potassium-sparing agents ... Low-Ceiling Diuretics and Potassium-Sparing Agents …

Levallorphan

An opioid antagonist with properties similar to those of naloxone; in addition it also possesses some agonist properties. It should be used cautiously; levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induced by alcohol or other non-opioid central depressants. (From Martindale, The Extra Pharmacopoeia,...
Approved

Phenprocoumon

Coumarin derivative that acts as a long-acting oral anticoagulant.
Approved
Investigational
Matched Categories: … Blood and Blood Forming Organs …

Tamoxifen

Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment for these types of cancers...
Approved
Matched Description: … treatment for these types of cancers as patients generally have better survival, side effect profiles, and …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Hormone Antagonists and Related Agents ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Idarubicin

An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity.
Approved
Matched Description: … The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential …
Matched Categories: … Anthracyclines and Related Substances ... Antineoplastic and Immunomodulating Agents ... Cytotoxic Antibiotics and Related Substances …

Propafenone

An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated.
Approved

Pazopanib

Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.
Approved
Matched Description: … It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Teriparatide

Teriparatide is a recombinant parathyroid hormone (PTH) analog and a potent osteoanabolic agent. It is made up of the first amino(N)-terminal 34 amino acids of the human PTH. First approved in the United States in November 2002 and in Europe in April 2003, teriparatide makes the first approved drug in...
Approved
Investigational
Matched Description: … Teriparatide is a recombinant parathyroid hormone (PTH) analog and a potent osteoanabolic agent. ... [A251395] Teriparatide is used in the treatment of osteoporosis in men and women.[L42590, L42595] ... [A251395] First approved in the United States in November 2002 and in Europe in April 2003,[A251400] …
Matched Categories: … Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... Parathyroid Hormones and Analogues ... Calcium-Regulating Hormones and Agents ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Albumin human

Human serum albumin is the primary protein present in human blood plasma. The main function of albumin is to maintain the oncotic pressure of blood . It binds to water, cations (such as Ca2+, Na+ and K+), fatty acids, hormones, bilirubin, thyroxine (T4) and pharmaceuticals (including barbiturates). Albumin represents approximately...
Approved
Matched Description: … ) and pharmaceuticals (including barbiturates). ... both 5% and 25% concentrations by the FDA on June 21, 2018 [L3101]. ... Each domain comprises two separate sub-domains (A and B) [A40060]. …
Matched Categories: … Blood and Related Products ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins ... Blood Substitutes and Perfusion Solutions ... Blood Substitutes and Plasma Protein Fractions …

Isopropamide

Isopropamide iodide is a long-acting quaternary anticholinergic drug. It is used in the treatment of peptic ulcer and other gastrointestinal disorders marked by hyperacidity and hypermotility.
Approved
Vet approved
Matched Description: … and hypermotility. ... It is used in the treatment of peptic ulcer and other gastrointestinal disorders marked by hyperacidity …
Matched Categories: … Alimentary Tract and Metabolism ... isopropamide and psycholeptics …

Venetoclax

Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types...
Approved
Investigational
Matched Description: … Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small lymphocytic …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Displaying drugs 2251 - 2275 of 14952 in total