|Accession Number||DB01230 (APRD01169)|
In 2005, the Food and Drug Administration (FDA) withdrew approval for pemoline. In March 2005, Abbott Laboratories (Cylert marketer) had discontinued the production of Cylert arguing economic reasons.
|External IDs||Not Available|
|Product Ingredients||Not Available|
|Approved Prescription Products||Not Available|
|Approved Generic Prescription Products||Not Available|
|Approved Over the Counter Products||Not Available|
|Unapproved/Other Products||Not Available|
|Brand mixtures||Not Available|
|Weight||Average: 176.172 |
For treatment of Attention Deficit Hyperactivity Disorder (ADHD)
|Structured Indications||Not Available|
Pemoline belongs to the group of medicines called central nervous system (CNS) stimulants. It is used to treat attention deficit hyperactivity disorder (ADHD). Pemoline stimulates the brain, probably by affecting neurotransmitters, the chemicals in the brain that nerves use to communicate with each other.
|Mechanism of action||Not Available|
Pemoline is rapidly absorbed from the gastrointestinal tract
|Volume of distribution||Not Available|
Approximately 50% (bound to plasma proteins).
|Route of elimination|
Pemoline is excreted primarily by the kidneys with approximately 50% excreted unchanged and only minor fractions present as metabolites.
The serum half-life of pemoline is approximately 12 hours.
Side effects include insomnia, anorexia, stomach ache, skin rashes, increased irritability, mild depression, nausea, dizziness, headache, drowsiness, and hallucinations
|Pharmacogenomic Effects/ADRs||Not Available|
|Drug Interactions||Not Available|
|Synthesis Reference||Not Available|
|General References||Not Available|
|ATC Codes||N06BA05 — Pemoline|
|AHFS Codes||Not Available|
|PDB Entries||Not Available|
|FDA label||Download (60.4 KB)|
|MSDS||Download (75 KB)|
|Dosage forms||Not Available|
|Predicted ADMET features|
|Mass Spec (NIST)||Not Available|
|Description||This compound belongs to the class of chemical entities known as ureides. These are compounds containing an ureide group with the general structure R1-CO-NH-CO-N(R)2R3, formally derived by the acylation of urea. They can be subdivided in N-acyl or N,N'-diacyl ureas.|
|Super Class||Organic compounds|
|Class||Organic acids and derivatives|
|Sub Class||Organic carbonic acids and derivatives|
|Alternative Parents||Benzene and substituted derivatives / Oxazolines / Propargyl-type 1,3-dipolar organic compounds / Oxacyclic compounds / Azacyclic compounds / Organopnictogen compounds / Organooxygen compounds / Imines / Hydrocarbon derivatives|
|Substituents||Ureide / Monocyclic benzene moiety / Benzenoid / Oxazoline / Propargyl-type 1,3-dipolar organic compound / Organic 1,3-dipolar compound / Organoheterocyclic compound / Azacycle / Oxacycle / Hydrocarbon derivative|
|Molecular Framework||Aromatic heteromonocyclic compounds|
|External Descriptors||1,3-oxazoles (CHEBI:7953 )|