Caffeine analogs: biomedical impact.
Article Details
- CitationCopy to clipboard
Daly JW
Caffeine analogs: biomedical impact.
Cell Mol Life Sci. 2007 Aug;64(16):2153-69.
- PubMed ID
- 17514358 [ View in PubMed]
- Abstract
Caffeine, widely consumed in beverages, and many xanthine analogs have had a major impact on biomedical research. Caffeine and various analogs, the latter designed to enhance potency and selectivity toward specific biological targets, have played key roles in defining the nature and role of adenosine receptors, phosphodiesterases, and calcium release channels in physiological processes. Such xanthines and other caffeine-inspired heterocycles now provide important research tools and potential therapeutic agents for intervention in Alzheimer's disease, asthma, cancer, diabetes, and Parkinson's disease. Such compounds also have activity as analgesics, antiinflammatories, antitussives, behavioral stimulants, diuretics/natriuretics, and lipolytics. Adverse effects can include anxiety, hypertension, certain drug interactions, and withdrawal symptoms.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Caffeine cAMP-specific 3',5'-cyclic phosphodiesterase 4B Protein Humans UnknownInhibitorDetails Caffeine Ryanodine receptor 1 Protein Humans UnknownNot Available Details Theobromine cAMP-specific 3',5'-cyclic phosphodiesterase 4B Protein Humans UnknownInhibitorDetails