Successful treatment of severe unconjugated hyperbilirubinemia via induction of UGT1A1 by rifampicin.

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Ellis E, Wagner M, Lammert F, Nemeth A, Gumhold J, Strassburg CP, Kylander C, Katsika D, Trauner M, Einarsson C, Marschall HU

Successful treatment of severe unconjugated hyperbilirubinemia via induction of UGT1A1 by rifampicin.

J Hepatol. 2006 Jan;44(1):243-5. Epub 2005 Oct 27.

PubMed ID

16288819 [ View in PubMed

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Abstract

We report two patients with uncommon Gilbert's syndrome with severe unconjugated hyperbilirubinemia which was reduced from 200 to 60-90 micromol/L by long-term administration of rifampicin. Hepatic induction of bilirubin-glucuronosyltransferase was suggested by increased relative amounts of conjugated serum bilirubin. This molecular mechanism was confirmed in primary cultures of human hepatocytes.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Rifampicin	UDP-glucuronosyltransferase 1-1	Protein	Humans	Unknown	Inducer	Details

Drug Interactions

Drugs	Interaction
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Raltegravir Rifabutin	The serum concentration of Raltegravir can be decreased when it is combined with Rifabutin.