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Identification
NameRifampicin
Accession NumberDB01045  (APRD00207, EXPT02777)
TypeSmall Molecule
GroupsApproved
DescriptionA semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
Structure
Thumb
Synonyms
3-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin sv
RFP
Rifampicina
Rifampicinum
Rifampin
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Rifadincapsule300 mg/1oralSanofi Aventis U.S. Llc1971-05-21Not applicableUs
Rifadincapsule150 mgoralSanofi Aventis Canada Inc1995-12-31Not applicableCanada
Rifadincapsule300 mgoralSanofi Aventis Canada Inc1995-12-31Not applicableCanada
Rifadin Cap 300mgcapsule300 mgoralMerrell Dow Pharmaceuticals (Canada) Inc., Division Of Mmdc1988-12-311996-09-09Canada
Rifadin IVinjection, powder, lyophilized, for solution600 mg/10mLintravenousSanofi Aventis U.S. Llc1989-05-25Not applicableUs
Rofact 150mgcapsule150 mgoralValeant Canada Lp Valeant Canada S.E.C.1977-12-31Not applicableCanada
Rofact 300mgcapsule300 mgoralValeant Canada Lp Valeant Canada S.E.C.1977-12-31Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Rifadincapsule150 mg/1oralSanofi Aventis U.S. Llc1981-07-15Not applicableUs
Rifampincapsule, coated300 mg/1oralCardinal Health2001-03-14Not applicableUs
Rifampininjection, powder, lyophilized, for solution600 mg/1intravenousWest Ward Pharmaceuticals Corp2016-03-03Not applicableUs
Rifampincapsule300 mg/1oral; oralMajor Pharmaceuticals2009-10-07Not applicableUs
Rifampincapsule150 mg/1oralREMEDYREPACK INC.2011-08-03Not applicableUs
Rifampincapsule150 mg/1oralAmerican Health Packaging2009-09-25Not applicableUs
Rifampininjection, powder, lyophilized, for solution600 mg/1intravenousFresenius Kabi USA, LLC2014-08-21Not applicableUs
Rifampincapsule, coated300 mg/1oralREMEDYREPACK INC.2013-10-29Not applicableUs
Rifampincapsule300 mg/1oralPhysicians Total Care, Inc.2008-04-20Not applicableUs
Rifampincapsule300 mg/1oralLupin Pharmaceuticals, Inc.2013-10-28Not applicableUs
Rifampincapsule150 mg/1oralEon Labs, Inc.1998-01-02Not applicableUs
Rifampincapsule300 mg/1oralClinical Solutions Wholesale, Llc2008-04-20Not applicableUs
Rifampininjection, powder, lyophilized, for solution600 mg/10mLintravenousAkorn, Inc.2012-06-01Not applicableUs
Rifampincapsule300 mg/1oralMylan Institutional Inc.1999-12-15Not applicableUs
Rifampincapsule300 mg/1oralAmerican Health Packaging2009-09-25Not applicableUs
Rifampininjection, powder, lyophilized, for solution600 mg/10mLintravenousPfizer Laboratories Div Pfizer Inc2011-05-10Not applicableUs
Rifampincapsule300 mg/1oralbryant ranch prepack1997-05-28Not applicableUs
Rifampincapsule300 mg/1oralRebel Distributors Corp2008-04-20Not applicableUs
Rifampincapsule150 mg/1oralPhysicians Total Care, Inc.2008-04-20Not applicableUs
Rifampincapsule300 mg/1oralDepartment Of State Health Services, Pharmacy Branch2001-07-01Not applicableUs
Rifampincapsule300 mg/1oralLannett Company, Inc.2008-04-20Not applicableUs
Rifampincapsule150 mg/1oralVersa Pharm Incorporated2001-07-01Not applicableUs
Rifampincapsule300 mg/1oralRebel Distributors Corp1997-05-28Not applicableUs
Rifampincapsule, coated300 mg/1oralH.J. Harkins Company, Inc.2001-07-01Not applicableUs
Rifampincapsule, coated300 mg/1oralCarilion Materials Management2001-07-01Not applicableUs
Rifampininjection, powder, lyophilized, for solution600 mg/10mLintravenousPfizer Laboratories Div Pfizer Inc2011-05-10Not applicableUs
Rifampincapsule300 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2006-11-30Not applicableUs
Rifampincapsule300 mg/1oralREMEDYREPACK INC.2011-03-28Not applicableUs
Rifampincapsule150 mg/1oralLannett Company, Inc.2008-04-20Not applicableUs
Rifampincapsule300 mg/1oralCardinal Health2011-05-20Not applicableUs
Rifampincapsule150 mg/1oralDepartment Of State Health Services, Pharmacy Branch2001-07-01Not applicableUs
Rifampincapsule300 mg/1oralVersa Pharm Incorporated2001-07-01Not applicableUs
Rifampininjection, powder, lyophilized, for solution600 mg/10mLintravenousHeritage Pharmaceuticals Inc.2014-08-18Not applicableUs
Rifampincapsule, coated300 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Rifampincapsule150 mg/1oralLupin Pharmaceuticals, Inc.2013-10-28Not applicableUs
Rifampincapsule300 mg/1oralEon Labs, Inc.1997-05-28Not applicableUs
Rifampininjection, powder, lyophilized, for solution600 mg/10mLintravenousMylan Institutional LLC2008-05-23Not applicableUs
Rifampincapsule150 mg/1oralREMEDYREPACK INC.2011-06-20Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
RifadineNot Available
RifaldinNot Available
RifoldinNot Available
RimactanNot Available
RimactaneNot Available
RofactNot Available
TubocinNot Available
Brand mixtures
NameLabellerIngredients
IsonarifVersa Pharm Incorporated
RifamateSanofi Aventis U.S. Llc
RifaterSanofi Aventis U.S. Llc
Salts
Name/CASStructureProperties
Rifampicin sodium
ThumbNot applicableDBSALT001014
Categories
UNIIVJT6J7R4TR
CAS number13292-46-1
WeightAverage: 822.9402
Monoisotopic: 822.40512334
Chemical FormulaC43H58N4O12
InChI KeyInChIKey=JQXXHWHPUNPDRT-WLSIYKJHSA-N
InChI
InChI=1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1
IUPAC Name
(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(1E)-[(4-methylpiperazin-1-yl)imino]methyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1⁴,⁷.0⁵,²⁸]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl acetate
SMILES
CO[[email protected]]1\C=C\O[C@@]2(C)OC3=C(C2=O)C2=C(O)C(\C=N\N4CCN(C)CC4)=C(NC(=O)\C(C)=C/C=C/[[email protected]](C)[[email protected]](O)[C@@H](C)[C@@H](O)[C@@H](C)[[email protected]](OC(C)=O)[C@@H]1C)C(O)=C2C(O)=C3C
Taxonomy
ClassificationNot classified
Pharmacology
IndicationFor the treatment of Tuberculosis and Tuberculosis-related mycobacterial infections.
PharmacodynamicsRifampin is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. It is bactericidal and has a very broad spectrum of activity against most gram-positive and gram-negative organisms (including Pseudomonas aeruginosa) and specifically Mycobacterium tuberculosis. Because of rapid emergence of resistant bacteria, use is restricted to treatment of mycobacterial infections and a few other indications. Rifampin is well absorbed when taken orally and is distributed widely in body tissues and fluids, including the CSF. It is metabolized in the liver and eliminated in bile and, to a much lesser extent, in urine, but dose adjustments are unnecessary with renal insufficiency.
Mechanism of actionRifampin acts via the inhibition of DNA-dependent RNA polymerase, leading to a suppression of RNA synthesis and cell death.
Related Articles
AbsorptionWell absorbed from gastrointestinal tract.
Volume of distributionNot Available
Protein binding89%
Metabolism

Primarily hepatic, rapidly deacetylated.

Route of eliminationLess than 30% of the dose is excreted in the urine as rifampin or metabolites.
Half life3.35 (+/- 0.66) hours
Clearance
  • 0.19 +/- 0.06 L/hr/kg [300 mg IV]
  • 0.14 +/- 0.03 L/hr/kg [600 mg IV]
ToxicityLD50=1570 mg/kg (rat), chronic exposure may cause nausea and vomiting and unconsciousness
Affected organisms
  • Mycobacteria
  • Mycobacterium tuberculosis
  • Various gram-negative and gram-positive eubacteria
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.5553
Blood Brain Barrier-0.974
Caco-2 permeable-0.7123
P-glycoprotein substrateSubstrate0.9308
P-glycoprotein inhibitor IInhibitor0.8564
P-glycoprotein inhibitor IINon-inhibitor0.6049
Renal organic cation transporterNon-inhibitor0.8178
CYP450 2C9 substrateNon-substrate0.8508
CYP450 2D6 substrateNon-substrate0.9115
CYP450 3A4 substrateSubstrate0.7296
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.907
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.8432
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9099
Ames testNon AMES toxic0.5803
CarcinogenicityNon-carcinogens0.8493
BiodegradationNot ready biodegradable0.9962
Rat acute toxicity2.6875 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.908
hERG inhibition (predictor II)Non-inhibitor0.5486
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Capsuleoral150 mg/1
Capsuleoral150 mg
Capsuleoral300 mg/1
Capsuleoral300 mg
Injection, powder, lyophilized, for solutionintravenous600 mg/10mL
Capsuleoral
Capsuleoral; oral300 mg/1
Capsule, coatedoral300 mg/1
Injection, powder, lyophilized, for solutionintravenous600 mg/1
Tabletoral
Tablet, sugar coatedoral
Prices
Unit descriptionCostUnit
Rifadin iv 600 mg vial140.9USD vial
Rifampin iv 600 mg vial136.3USD vial
Rifampin crystals6.72USD g
Rifampin powder3.98USD g
Rifadin 300 mg capsule3.09USD capsule
Rifadin 150 mg capsule2.57USD capsule
Rifampin 300 mg capsule2.37USD capsule
Rimactane 300 mg capsule2.35USD capsule
Rifampin 150 mg capsule2.27USD capsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point183 °CNot Available
water solubility1400 mg/L (at 25 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP2.7Not Available
pKa1.7SANGSTER (2004)
Predicted Properties
PropertyValueSource
Water Solubility0.0413 mg/mLALOGPS
logP3.85ALOGPS
logP2.77ChemAxon
logS-4.3ALOGPS
pKa (Strongest Acidic)6.9ChemAxon
pKa (Strongest Basic)7.53ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count14ChemAxon
Hydrogen Donor Count6ChemAxon
Polar Surface Area220.15 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity225.58 m3·mol-1ChemAxon
Polarizability86.46 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

Klaus Jurgen, Joachim Seydel, “Combination preparations containing rifampicin and thioacetazon.” U.S. Patent US5104875, issued August, 1973.

US5104875
General References
  1. Baysarowich J, Koteva K, Hughes DW, Ejim L, Griffiths E, Zhang K, Junop M, Wright GD: Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr. Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4886-91. doi: 10.1073/pnas.0711939105. Epub 2008 Mar 18. [PubMed:18349144 ]
External Links
ATC CodesJ04AB02J04AM02J04AM06J04AM05
AHFS Codes
  • 08:16.04
PDB Entries
FDA labelDownload (43.3 KB)
MSDSDownload (86.7 KB)
Interactions
Drug Interactions
Drug
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be decreased when it is combined with Rifampicin.
AbirateroneThe serum concentration of Abiraterone can be decreased when it is combined with Rifampicin.
AbirateroneThe serum concentration of Rifampicin can be increased when it is combined with Abiraterone.
AcebutololThe serum concentration of Acebutolol can be decreased when it is combined with Rifampicin.
AceclofenacThe metabolism of Aceclofenac can be increased when combined with Rifampicin.
AcenocoumarolThe metabolism of Acenocoumarol can be increased when combined with Rifampicin.
AcetaminophenThe serum concentration of Acetaminophen can be decreased when it is combined with Rifampicin.
AcetaminophenThe serum concentration of Rifampicin can be increased when it is combined with Acetaminophen.
AcetohexamideThe serum concentration of Acetohexamide can be decreased when it is combined with Rifampicin.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be decreased when it is combined with Rifampicin.
AdinazolamThe metabolism of Adinazolam can be increased when combined with Rifampicin.
AfatinibThe serum concentration of Afatinib can be decreased when it is combined with Rifampicin.
AfatinibThe serum concentration of Rifampicin can be increased when it is combined with Afatinib.
AlbendazoleThe metabolism of Albendazole can be increased when combined with Rifampicin.
AlbendazoleThe serum concentration of Rifampicin can be increased when it is combined with Albendazole.
AlclometasoneThe serum concentration of Alclometasone can be decreased when it is combined with Rifampicin.
AldosteroneThe serum concentration of Aldosterone can be decreased when it is combined with Rifampicin.
AlectinibThe serum concentration of Rifampicin can be increased when it is combined with Alectinib.
AlfentanilThe metabolism of Alfentanil can be increased when combined with Rifampicin.
AlfentanilThe serum concentration of Rifampicin can be increased when it is combined with Alfentanil.
AlfuzosinThe metabolism of Alfuzosin can be increased when combined with Rifampicin.
AliskirenThe metabolism of Aliskiren can be increased when combined with Rifampicin.
AlitretinoinThe serum concentration of Alitretinoin can be decreased when it is combined with Rifampicin.
AllylestrenolThe metabolism of Allylestrenol can be increased when combined with Rifampicin.
AlmotriptanThe metabolism of Almotriptan can be increased when combined with Rifampicin.
AlogliptinThe metabolism of Alogliptin can be increased when combined with Rifampicin.
AlosetronThe metabolism of Alosetron can be increased when combined with Rifampicin.
AlprazolamThe metabolism of Alprazolam can be increased when combined with Rifampicin.
AmantadineThe serum concentration of Rifampicin can be increased when it is combined with Amantadine.
AmbrisentanThe serum concentration of Ambrisentan can be decreased when it is combined with Rifampicin.
AmbroxolThe metabolism of Ambroxol can be increased when combined with Rifampicin.
AmcinonideThe serum concentration of Amcinonide can be decreased when it is combined with Rifampicin.
Aminohippuric acidThe serum concentration of Rifampicin can be increased when it is combined with Aminohippuric acid.
AminophenazoneThe metabolism of Aminophenazone can be increased when combined with Rifampicin.
AminophyllineThe metabolism of Aminophylline can be increased when combined with Rifampicin.
AmiodaroneThe serum concentration of the active metabolites of Amiodarone can be reduced when Amiodarone is used in combination with Rifampicin resulting in a loss in efficacy.
AmiodaroneThe serum concentration of Rifampicin can be decreased when it is combined with Amiodarone.
AmitriptylineThe serum concentration of Amitriptyline can be decreased when it is combined with Rifampicin.
AmitriptylineThe serum concentration of Rifampicin can be increased when it is combined with Amitriptyline.
AmlodipineThe metabolism of Amlodipine can be increased when combined with Rifampicin.
AmlodipineThe serum concentration of Rifampicin can be increased when it is combined with Amlodipine.
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Rifampicin.
AmoxicillinThe metabolism of Amoxicillin can be increased when combined with Rifampicin.
AmprenavirThe metabolism of Amprenavir can be increased when combined with Rifampicin.
AmprenavirThe serum concentration of Rifampicin can be decreased when it is combined with Amprenavir.
AmsacrineThe serum concentration of Rifampicin can be increased when it is combined with Amsacrine.
AnagrelideThe metabolism of Anagrelide can be increased when combined with Rifampicin.
AntipyrineThe metabolism of Antipyrine can be increased when combined with Rifampicin.
ApixabanThe serum concentration of Apixaban can be decreased when it is combined with Rifampicin.
ApremilastThe serum concentration of Apremilast can be decreased when it is combined with Rifampicin.
AprepitantThe serum concentration of Rifampicin can be increased when it is combined with Aprepitant.
AprepitantThe serum concentration of Aprepitant can be decreased when it is combined with Rifampicin.
Arachidonic AcidThe metabolism of Arachidonic Acid can be increased when combined with Rifampicin.
ArformoterolThe metabolism of Arformoterol can be increased when combined with Rifampicin.
ArgatrobanThe metabolism of Argatroban can be increased when combined with Rifampicin.
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Rifampicin.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be decreased when it is combined with Rifampicin.
ArtemetherThe serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with Rifampicin resulting in a loss in efficacy.
ArtesunateThe serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with Rifampicin resulting in a loss in efficacy.
ASA404The metabolism of ASA404 can be increased when combined with Rifampicin.
AsenapineThe metabolism of Asenapine can be increased when combined with Rifampicin.
AstemizoleThe metabolism of Astemizole can be increased when combined with Rifampicin.
AstemizoleThe serum concentration of Rifampicin can be increased when it is combined with Astemizole.
AtazanavirThe serum concentration of Atazanavir can be decreased when it is combined with Rifampicin.
AtazanavirThe serum concentration of Rifampicin can be increased when it is combined with Atazanavir.
AtenololThe serum concentration of Atenolol can be decreased when it is combined with Rifampicin.
AtenololThe serum concentration of Rifampicin can be increased when it is combined with Atenolol.
AtomoxetineThe metabolism of Rifampicin can be decreased when combined with Atomoxetine.
AtorvastatinThe metabolism of Atorvastatin can be increased when combined with Rifampicin.
AtorvastatinThe serum concentration of Rifampicin can be increased when it is combined with Atorvastatin.
AV650The metabolism of AV650 can be increased when combined with Rifampicin.
AvanafilThe metabolism of Avanafil can be increased when combined with Rifampicin.
AxitinibThe serum concentration of Axitinib can be decreased when it is combined with Rifampicin.
AzelastineThe metabolism of Azelastine can be increased when combined with Rifampicin.
AzelastineThe serum concentration of Rifampicin can be increased when it is combined with Azelastine.
AzithromycinThe metabolism of Azithromycin can be increased when combined with Rifampicin.
AzithromycinThe serum concentration of Rifampicin can be increased when it is combined with Azithromycin.
BanoxantroneThe metabolism of Banoxantrone can be increased when combined with Rifampicin.
BazedoxifeneThe serum concentration of Bazedoxifene can be decreased when it is combined with Rifampicin.
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be decreased when it is combined with Rifampicin.
BedaquilineThe serum concentration of Bedaquiline can be decreased when it is combined with Rifampicin.
BendamustineThe serum concentration of Bendamustine can be decreased when it is combined with Rifampicin.
BenzatropineThe metabolism of Benzatropine can be increased when combined with Rifampicin.
BenzocaineThe serum concentration of Rifampicin can be increased when it is combined with Benzocaine.
BenzphetamineThe metabolism of Benzphetamine can be increased when combined with Rifampicin.
Benzyl alcoholThe metabolism of Benzyl alcohol can be increased when combined with Rifampicin.
BepridilThe serum concentration of Rifampicin can be increased when it is combined with Bepridil.
BeraprostThe metabolism of Beraprost can be increased when combined with Rifampicin.
BetamethasoneThe serum concentration of Betamethasone can be decreased when it is combined with Rifampicin.
BetaxololThe metabolism of Betaxolol can be increased when combined with Rifampicin.
BexaroteneThe serum concentration of Rifampicin can be decreased when it is combined with Bexarotene.
BexaroteneThe metabolism of Bexarotene can be increased when combined with Rifampicin.
BezafibrateThe metabolism of Bezafibrate can be increased when combined with Rifampicin.
BicalutamideThe metabolism of Bicalutamide can be increased when combined with Rifampicin.
BiperidenThe serum concentration of Rifampicin can be increased when it is combined with Biperiden.
BisoprololThe metabolism of Bisoprolol can be increased when combined with Rifampicin.
BoceprevirThe serum concentration of Boceprevir can be decreased when it is combined with Rifampicin.
BoceprevirThe metabolism of Rifampicin can be decreased when combined with Boceprevir.
BortezomibThe serum concentration of Bortezomib can be decreased when it is combined with Rifampicin.
BortezomibThe metabolism of Rifampicin can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Rifampicin can be decreased when it is combined with Bosentan.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Rifampicin.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Rifampicin.
BrexpiprazoleThe serum concentration of Brexpiprazole can be decreased when it is combined with Rifampicin.
BrinzolamideThe metabolism of Brinzolamide can be increased when combined with Rifampicin.
BromazepamThe metabolism of Bromazepam can be increased when combined with Rifampicin.
BromocriptineThe serum concentration of Bromocriptine can be decreased when it is combined with Rifampicin.
BromocriptineThe serum concentration of Rifampicin can be increased when it is combined with Bromocriptine.
BrompheniramineThe metabolism of Brompheniramine can be increased when combined with Rifampicin.
BudesonideThe serum concentration of Budesonide can be decreased when it is combined with Rifampicin.
BupivacaineThe metabolism of Bupivacaine can be increased when combined with Rifampicin.
BuprenorphineThe metabolism of Buprenorphine can be increased when combined with Rifampicin.
BuprenorphineThe serum concentration of Rifampicin can be increased when it is combined with Buprenorphine.
BupropionThe metabolism of Bupropion can be increased when combined with Rifampicin.
BuspironeThe metabolism of Buspirone can be increased when combined with Rifampicin.
BuspironeThe serum concentration of Rifampicin can be increased when it is combined with Buspirone.
BusulfanThe metabolism of Busulfan can be increased when combined with Rifampicin.
CabazitaxelThe serum concentration of Cabazitaxel can be decreased when it is combined with Rifampicin.
CabazitaxelThe serum concentration of Rifampicin can be increased when it is combined with Cabazitaxel.
CabergolineThe metabolism of Cabergoline can be increased when combined with Rifampicin.
CabozantinibThe serum concentration of Cabozantinib can be decreased when it is combined with Rifampicin.
CaffeineThe serum concentration of Caffeine can be decreased when it is combined with Rifampicin.
CaffeineThe serum concentration of Rifampicin can be increased when it is combined with Caffeine.
CalcitriolThe metabolism of Calcitriol can be increased when combined with Rifampicin.
CamptothecinThe serum concentration of Camptothecin can be decreased when it is combined with Rifampicin.
CanagliflozinThe serum concentration of Canagliflozin can be decreased when it is combined with Rifampicin.
CanagliflozinThe serum concentration of Rifampicin can be increased when it is combined with Canagliflozin.
CandesartanThe serum concentration of Rifampicin can be increased when it is combined with Candesartan.
CandesartanThe metabolism of Candesartan can be increased when combined with Rifampicin.
CannabidiolThe serum concentration of Cannabidiol can be decreased when it is combined with Rifampicin.
CapecitabineThe metabolism of Rifampicin can be decreased when combined with Capecitabine.
CaptoprilThe serum concentration of Rifampicin can be increased when it is combined with Captopril.
CarbamazepineThe serum concentration of Carbamazepine can be decreased when it is combined with Rifampicin.
CarbinoxamineThe metabolism of Carbinoxamine can be increased when combined with Rifampicin.
CarfilzomibThe serum concentration of Carfilzomib can be decreased when it is combined with Rifampicin.
CariprazineThe metabolism of Cariprazine can be increased when combined with Rifampicin.
CarisoprodolThe metabolism of Carisoprodol can be increased when combined with Rifampicin.
CarmustineThe metabolism of Carmustine can be increased when combined with Rifampicin.
CarvedilolThe metabolism of Carvedilol can be increased when combined with Rifampicin.
CarvedilolThe serum concentration of Rifampicin can be increased when it is combined with Carvedilol.
CaspofunginThe serum concentration of Caspofungin can be decreased when it is combined with Rifampicin.
CaspofunginThe serum concentration of Rifampicin can be increased when it is combined with Caspofungin.
CelecoxibThe metabolism of Celecoxib can be increased when combined with Rifampicin.
CeliprololThe metabolism of Celiprolol can be increased when combined with Rifampicin.
CephalexinThe metabolism of Cephalexin can be increased when combined with Rifampicin.
CeritinibThe serum concentration of Rifampicin can be increased when it is combined with Ceritinib.
CeritinibThe serum concentration of Ceritinib can be decreased when it is combined with Rifampicin.
CerivastatinThe serum concentration of Cerivastatin can be decreased when it is combined with Rifampicin.
CevimelineThe metabolism of Cevimeline can be increased when combined with Rifampicin.
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be increased when combined with Rifampicin.
ChloramphenicolThe metabolism of Chloramphenicol can be increased when combined with Rifampicin.
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be increased when combined with Rifampicin.
ChloroquineThe metabolism of Chloroquine can be increased when combined with Rifampicin.
ChloroquineThe serum concentration of Rifampicin can be increased when it is combined with Chloroquine.
ChlorphenamineThe metabolism of Chlorphenamine can be increased when combined with Rifampicin.
ChlorpromazineThe serum concentration of Chlorpromazine can be decreased when it is combined with Rifampicin.
ChlorpromazineThe serum concentration of Rifampicin can be increased when it is combined with Chlorpromazine.
ChlorpropamideThe serum concentration of Chlorpropamide can be decreased when it is combined with Rifampicin.
ChlorpropamideThe serum concentration of Rifampicin can be increased when it is combined with Chlorpropamide.
ChlorprothixeneThe serum concentration of Rifampicin can be increased when it is combined with Chlorprothixene.
ChlorzoxazoneThe metabolism of Chlorzoxazone can be increased when combined with Rifampicin.
CholecalciferolThe metabolism of Cholecalciferol can be increased when combined with Rifampicin.
CholesterolThe serum concentration of Rifampicin can be increased when it is combined with Cholesterol.
Cholic AcidThe serum concentration of Rifampicin can be decreased when it is combined with Cholic Acid.
CiclesonideThe serum concentration of Ciclesonide can be decreased when it is combined with Rifampicin.
CilazaprilThe serum concentration of Rifampicin can be increased when it is combined with Cilazapril.
CilostazolThe metabolism of Cilostazol can be increased when combined with Rifampicin.
CimetidineThe serum concentration of Cimetidine can be decreased when it is combined with Rifampicin.
CinacalcetThe metabolism of Cinacalcet can be increased when combined with Rifampicin.
CinnarizineThe metabolism of Cinnarizine can be increased when combined with Rifampicin.
CiprofloxacinThe serum concentration of Ciprofloxacin can be decreased when it is combined with Rifampicin.
CiprofloxacinThe serum concentration of Rifampicin can be increased when it is combined with Ciprofloxacin.
CisaprideThe metabolism of Cisapride can be increased when combined with Rifampicin.
CisplatinThe serum concentration of Cisplatin can be decreased when it is combined with Rifampicin.
CitalopramThe serum concentration of Citalopram can be decreased when it is combined with Rifampicin.
CitalopramThe serum concentration of Rifampicin can be increased when it is combined with Citalopram.
ClarithromycinThe serum concentration of Clarithromycin can be decreased when it is combined with Rifampicin.
ClarithromycinThe serum concentration of Rifampicin can be increased when it is combined with Clarithromycin.
ClemastineThe metabolism of Rifampicin can be decreased when combined with Clemastine.
ClenbuterolThe metabolism of Clenbuterol can be increased when combined with Rifampicin.
ClevidipineThe metabolism of Clevidipine can be increased when combined with Rifampicin.
ClindamycinThe metabolism of Clindamycin can be increased when combined with Rifampicin.
ClobazamThe serum concentration of Clobazam can be decreased when it is combined with Rifampicin.
Clobetasol propionateThe serum concentration of Clobetasol propionate can be decreased when it is combined with Rifampicin.
ClocortoloneThe serum concentration of Clocortolone can be decreased when it is combined with Rifampicin.
ClofazimineThe metabolism of Clofazimine can be increased when combined with Rifampicin.
ClofazimineThe serum concentration of Rifampicin can be increased when it is combined with Clofazimine.
ClofibrateThe metabolism of Clofibrate can be increased when combined with Rifampicin.
clomethiazoleThe metabolism of clomethiazole can be increased when combined with Rifampicin.
ClomifeneThe serum concentration of Clomifene can be decreased when it is combined with Rifampicin.
ClomipramineThe metabolism of Clomipramine can be increased when combined with Rifampicin.
ClomipramineThe serum concentration of Rifampicin can be increased when it is combined with Clomipramine.
ClonazepamThe metabolism of Clonazepam can be increased when combined with Rifampicin.
ClonidineThe serum concentration of Clonidine can be decreased when it is combined with Rifampicin.
ClopidogrelThe serum concentration of Clopidogrel can be decreased when it is combined with Rifampicin.
ClopidogrelThe metabolism of Rifampicin can be decreased when combined with Clopidogrel.
ClorazepateThe metabolism of Clorazepate can be increased when combined with Rifampicin.
ClotiazepamThe metabolism of Clotiazepam can be increased when combined with Rifampicin.
ClotrimazoleThe metabolism of Rifampicin can be decreased when combined with Clotrimazole.
ClozapineThe serum concentration of Clozapine can be decreased when it is combined with Rifampicin.
CobicistatThe serum concentration of Cobicistat can be decreased when it is combined with Rifampicin.
CobicistatThe serum concentration of Rifampicin can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be decreased when it is combined with Rifampicin.
CocaineThe metabolism of Cocaine can be increased when combined with Rifampicin.
CodeineThe metabolism of Codeine can be increased when combined with Rifampicin.
ColchicineThe serum concentration of Colchicine can be decreased when it is combined with Rifampicin.
ColchicineThe serum concentration of Rifampicin can be increased when it is combined with Colchicine.
ColforsinThe serum concentration of Rifampicin can be increased when it is combined with Colforsin.
ConivaptanThe serum concentration of Rifampicin can be increased when it is combined with Conivaptan.
ConivaptanThe metabolism of Conivaptan can be increased when combined with Rifampicin.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be decreased when it is combined with Rifampicin.
Cortisone acetateThe serum concentration of Cortisone acetate can be decreased when it is combined with Rifampicin.
CrizotinibThe serum concentration of Crizotinib can be decreased when it is combined with Rifampicin.
CrizotinibThe metabolism of Rifampicin can be decreased when combined with Crizotinib.
CyclobenzaprineThe metabolism of Cyclobenzaprine can be increased when combined with Rifampicin.
CyclophosphamideThe metabolism of Cyclophosphamide can be increased when combined with Rifampicin.
CyclophosphamideThe serum concentration of Rifampicin can be increased when it is combined with Cyclophosphamide.
CyclosporineThe metabolism of Rifampicin can be decreased when combined with Cyclosporine.
CyclosporineThe serum concentration of Cyclosporine can be decreased when it is combined with Rifampicin.
CytarabineThe metabolism of Cytarabine can be increased when combined with Rifampicin.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be decreased when it is combined with Rifampicin.
DabrafenibThe serum concentration of Rifampicin can be decreased when it is combined with Dabrafenib.
DacarbazineThe metabolism of Dacarbazine can be increased when combined with Rifampicin.
DaclatasvirThe serum concentration of Daclatasvir can be decreased when it is combined with Rifampicin.
DaclatasvirThe serum concentration of Rifampicin can be increased when it is combined with Daclatasvir.
DactinomycinThe serum concentration of Dactinomycin can be decreased when it is combined with Rifampicin.
DactinomycinThe serum concentration of Rifampicin can be increased when it is combined with Dactinomycin.
DantroleneThe metabolism of Dantrolene can be increased when combined with Rifampicin.
DapagliflozinThe serum concentration of Dapagliflozin can be decreased when it is combined with Rifampicin.
DapsoneThe metabolism of Dapsone can be increased when combined with Rifampicin.
DarifenacinThe metabolism of Darifenacin can be increased when combined with Rifampicin.
DarunavirThe serum concentration of Darunavir can be decreased when it is combined with Rifampicin.
DarunavirThe metabolism of Rifampicin can be decreased when combined with Darunavir.
DasabuvirThe metabolism of Dasabuvir can be increased when combined with Rifampicin.
DasatinibThe serum concentration of Rifampicin can be increased when it is combined with Dasatinib.
DasatinibThe serum concentration of Dasatinib can be decreased when it is combined with Rifampicin.
DaunorubicinThe serum concentration of Daunorubicin can be decreased when it is combined with Rifampicin.
DebrisoquinThe serum concentration of Debrisoquin can be decreased when it is combined with Rifampicin.
DeferasiroxThe serum concentration of Rifampicin can be decreased when it is combined with Deferasirox.
DehydroepiandrosteroneThe serum concentration of Dehydroepiandrosterone can be decreased when it is combined with Rifampicin.
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be decreased when it is combined with Rifampicin.
DelavirdineThe metabolism of Delavirdine can be increased when combined with Rifampicin.
DesipramineThe serum concentration of Rifampicin can be increased when it is combined with Desipramine.
DesipramineThe metabolism of Desipramine can be increased when combined with Rifampicin.
DesloratadineThe serum concentration of Rifampicin can be increased when it is combined with Desloratadine.
DesoximetasoneThe serum concentration of Desoximetasone can be decreased when it is combined with Rifampicin.
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be decreased when it is combined with Rifampicin.
DesvenlafaxineThe metabolism of Desvenlafaxine can be increased when combined with Rifampicin.
DexamethasoneThe serum concentration of Rifampicin can be decreased when it is combined with Dexamethasone.
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be decreased when it is combined with Rifampicin.
DexfenfluramineThe metabolism of Dexfenfluramine can be increased when combined with Rifampicin.
DextromethorphanThe metabolism of Dextromethorphan can be increased when combined with Rifampicin.
DextromethorphanThe serum concentration of Rifampicin can be increased when it is combined with Dextromethorphan.
DextropropoxypheneThe metabolism of Dextropropoxyphene can be increased when combined with Rifampicin.
DiazepamThe serum concentration of Diazepam can be decreased when it is combined with Rifampicin.
DiclofenacThe serum concentration of Diclofenac can be decreased when it is combined with Rifampicin.
DiclofenacThe serum concentration of Rifampicin can be increased when it is combined with Diclofenac.
DicoumarolThe metabolism of Dicoumarol can be increased when combined with Rifampicin.
DienogestThe serum concentration of Dienogest can be decreased when it is combined with Rifampicin.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Rifampicin.
DiflorasoneThe serum concentration of Diflorasone can be decreased when it is combined with Rifampicin.
DifluocortoloneThe serum concentration of Difluocortolone can be decreased when it is combined with Rifampicin.
DifluprednateThe serum concentration of Difluprednate can be decreased when it is combined with Rifampicin.
DigitoxinThe serum concentration of Digitoxin can be decreased when it is combined with Rifampicin.
DigoxinThe serum concentration of Digoxin can be decreased when it is combined with Rifampicin.
DihydrocodeineThe metabolism of Dihydrocodeine can be increased when combined with Rifampicin.
DihydroergotamineThe metabolism of Dihydroergotamine can be increased when combined with Rifampicin.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Rifampicin.
DiltiazemThe serum concentration of Diltiazem can be decreased when it is combined with Rifampicin.
DiltiazemThe metabolism of Rifampicin can be decreased when combined with Diltiazem.
DinoprostoneThe metabolism of Dinoprostone can be increased when combined with Rifampicin.
DiphenhydramineThe metabolism of Diphenhydramine can be increased when combined with Rifampicin.
DipyridamoleThe serum concentration of Dipyridamole can be decreased when it is combined with Rifampicin.
DipyridamoleThe serum concentration of Rifampicin can be increased when it is combined with Dipyridamole.
DisopyramideThe serum concentration of Disopyramide can be decreased when it is combined with Rifampicin.
DisulfiramThe metabolism of Disulfiram can be increased when combined with Rifampicin.
DocetaxelThe serum concentration of Docetaxel can be decreased when it is combined with Rifampicin.
DofetilideThe metabolism of Dofetilide can be increased when combined with Rifampicin.
DolasetronThe metabolism of Dolasetron can be increased when combined with Rifampicin.
DolutegravirThe serum concentration of Dolutegravir can be decreased when it is combined with Rifampicin.
DomperidoneThe serum concentration of Domperidone can be decreased when it is combined with Rifampicin.
DonepezilThe metabolism of Donepezil can be increased when combined with Rifampicin.
DopamineThe metabolism of Dopamine can be increased when combined with Rifampicin.
DorzolamideThe metabolism of Dorzolamide can be increased when combined with Rifampicin.
DoxazosinThe serum concentration of Rifampicin can be increased when it is combined with Doxazosin.
DoxazosinThe metabolism of Doxazosin can be increased when combined with Rifampicin.
DoxepinThe metabolism of Doxepin can be increased when combined with Rifampicin.
DoxepinThe serum concentration of Rifampicin can be increased when it is combined with Doxepin.
DoxorubicinThe serum concentration of Doxorubicin can be decreased when it is combined with Rifampicin.
DoxycyclineThe serum concentration of Doxycycline can be decreased when it is combined with Rifampicin.
DoxycyclineThe metabolism of Rifampicin can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Dronabinol can be decreased when it is combined with Rifampicin.
DronabinolThe serum concentration of Rifampicin can be increased when it is combined with Dronabinol.
DronedaroneThe serum concentration of Dronedarone can be decreased when it is combined with Rifampicin.
DronedaroneThe metabolism of Rifampicin can be decreased when combined with Dronedarone.
DuloxetineThe metabolism of Duloxetine can be increased when combined with Rifampicin.
DutasterideThe metabolism of Dutasteride can be increased when combined with Rifampicin.
EdoxabanThe serum concentration of Edoxaban can be decreased when it is combined with Rifampicin.
EfavirenzThe serum concentration of Efavirenz can be decreased when it is combined with Rifampicin.
ElbasvirThe serum concentration of Rifampicin can be increased when it is combined with Elbasvir.
EletriptanThe serum concentration of Eletriptan can be decreased when it is combined with Rifampicin.
EliglustatThe serum concentration of Eliglustat can be decreased when it is combined with Rifampicin.
EltrombopagThe metabolism of Eltrombopag can be increased when combined with Rifampicin.
EluxadolineThe serum concentration of Eluxadoline can be increased when it is combined with Rifampicin.
ElvitegravirThe serum concentration of Elvitegravir can be decreased when it is combined with Rifampicin.
EnalaprilThe metabolism of Enalapril can be increased when combined with Rifampicin.
EnalaprilThe serum concentration of Rifampicin can be increased when it is combined with Enalapril.
EnfuvirtideThe metabolism of Enfuvirtide can be increased when combined with Rifampicin.
EnzalutamideThe serum concentration of Enzalutamide can be decreased when it is combined with Rifampicin.
EnzalutamideThe serum concentration of Rifampicin can be increased when it is combined with Enzalutamide.
EpinastineThe serum concentration of Epinastine can be decreased when it is combined with Rifampicin.
EplerenoneThe metabolism of Eplerenone can be increased when combined with Rifampicin.
EpoprostenolThe metabolism of Epoprostenol can be increased when combined with Rifampicin.
EquileninThe serum concentration of Equilenin can be decreased when it is combined with Rifampicin.
EquilinThe serum concentration of Equilin can be decreased when it is combined with Rifampicin.
ErgocalciferolThe metabolism of Ergocalciferol can be increased when combined with Rifampicin.
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be increased when combined with Rifampicin.
ErgonovineThe metabolism of Ergonovine can be increased when combined with Rifampicin.
ErgonovineThe serum concentration of Rifampicin can be increased when it is combined with Ergonovine.
ErgotamineThe metabolism of Ergotamine can be increased when combined with Rifampicin.
ErgotamineThe serum concentration of Rifampicin can be increased when it is combined with Ergotamine.
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Rifampicin.
ErythromycinThe metabolism of Rifampicin can be decreased when combined with Erythromycin.
ErythromycinThe serum concentration of Erythromycin can be decreased when it is combined with Rifampicin.
EscitalopramThe metabolism of Escitalopram can be increased when combined with Rifampicin.
Eslicarbazepine acetateThe serum concentration of Rifampicin can be decreased when it is combined with Eslicarbazepine acetate.
EsomeprazoleThe serum concentration of Esomeprazole can be decreased when it is combined with Rifampicin.
EstazolamThe metabolism of Estazolam can be increased when combined with Rifampicin.
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Rifampicin.
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be increased when combined with Rifampicin.
EstramustineThe metabolism of Estramustine can be increased when combined with Rifampicin.
EstramustineThe serum concentration of Rifampicin can be increased when it is combined with Estramustine.
EstriolThe serum concentration of Estriol can be decreased when it is combined with Rifampicin.
EstroneThe serum concentration of Estrone can be decreased when it is combined with Rifampicin.
Estrone sulfateThe metabolism of Estrone sulfate can be increased when combined with Rifampicin.
EszopicloneThe metabolism of Eszopiclone can be increased when combined with Rifampicin.
EthanolThe metabolism of Ethanol can be increased when combined with Rifampicin.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Rifampicin.
EthosuximideThe metabolism of Ethosuximide can be increased when combined with Rifampicin.
EthylmorphineThe metabolism of Ethylmorphine can be increased when combined with Rifampicin.
EtodolacThe metabolism of Etodolac can be increased when combined with Rifampicin.
EtonogestrelThe metabolism of Etonogestrel can be increased when combined with Rifampicin.
EtoposideThe serum concentration of Etoposide can be decreased when it is combined with Rifampicin.
EtoposideThe serum concentration of Rifampicin can be increased when it is combined with Etoposide.
EtoricoxibThe metabolism of Etoricoxib can be increased when combined with Rifampicin.
EtravirineThe serum concentration of Rifampicin can be decreased when it is combined with Etravirine.
EtravirineThe metabolism of Etravirine can be increased when combined with Rifampicin.
EverolimusThe serum concentration of Everolimus can be decreased when it is combined with Rifampicin.
ExemestaneThe serum concentration of Exemestane can be decreased when it is combined with Rifampicin.
EzetimibeThe serum concentration of Ezetimibe can be decreased when it is combined with Rifampicin.
FamciclovirThe metabolism of Famciclovir can be increased when combined with Rifampicin.
FamotidineThe metabolism of Famotidine can be increased when combined with Rifampicin.
FelbamateThe metabolism of Felbamate can be increased when combined with Rifampicin.
FelodipineThe metabolism of Felodipine can be increased when combined with Rifampicin.
FelodipineThe serum concentration of Rifampicin can be increased when it is combined with Felodipine.
FenofibrateThe metabolism of Fenofibrate can be increased when combined with Rifampicin.
FentanylThe serum concentration of Fentanyl can be decreased when it is combined with Rifampicin.
FentanylThe serum concentration of Rifampicin can be increased when it is combined with Fentanyl.
FesoterodineThe serum concentration of Fesoterodine can be decreased when it is combined with Rifampicin.
FexofenadineThe serum concentration of Fexofenadine can be decreased when it is combined with Rifampicin.
FexofenadineThe serum concentration of Rifampicin can be increased when it is combined with Fexofenadine.
FidaxomicinThe serum concentration of Fidaxomicin can be decreased when it is combined with Rifampicin.
FidaxomicinThe serum concentration of Rifampicin can be increased when it is combined with Fidaxomicin.
FimasartanThe serum concentration of Fimasartan can be increased when it is combined with Rifampicin.
FinasterideThe metabolism of Finasteride can be increased when combined with Rifampicin.
FingolimodThe metabolism of Fingolimod can be increased when combined with Rifampicin.
FlibanserinThe serum concentration of Flibanserin can be decreased when it is combined with Rifampicin.
FloxuridineThe metabolism of Rifampicin can be decreased when combined with Floxuridine.
FluconazoleThe metabolism of Rifampicin can be decreased when combined with Fluconazole.
FludrocortisoneThe serum concentration of Fludrocortisone can be decreased when it is combined with Rifampicin.
FlumethasoneThe serum concentration of Flumethasone can be decreased when it is combined with Rifampicin.
FlunarizineThe metabolism of Flunarizine can be increased when combined with Rifampicin.
FlunisolideThe serum concentration of Flunisolide can be decreased when it is combined with Rifampicin.
FlunitrazepamThe metabolism of Flunitrazepam can be increased when combined with Rifampicin.
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be decreased when it is combined with Rifampicin.
FluocinonideThe serum concentration of Fluocinonide can be decreased when it is combined with Rifampicin.
FluocortoloneThe serum concentration of Fluocortolone can be decreased when it is combined with Rifampicin.
FluorometholoneThe serum concentration of Fluorometholone can be decreased when it is combined with Rifampicin.
FluorouracilThe metabolism of Fluorouracil can be increased when combined with Rifampicin.
FluoxetineThe metabolism of Fluoxetine can be increased when combined with Rifampicin.
FluoxetineThe serum concentration of Rifampicin can be increased when it is combined with Fluoxetine.
FlupentixolThe serum concentration of Rifampicin can be increased when it is combined with Flupentixol.
FluphenazineThe serum concentration of Rifampicin can be increased when it is combined with Fluphenazine.
FluprednideneThe serum concentration of Fluprednidene can be decreased when it is combined with Rifampicin.
FluprednisoloneThe serum concentration of Fluprednisolone can be decreased when it is combined with Rifampicin.
FlurandrenolideThe serum concentration of Flurandrenolide can be decreased when it is combined with Rifampicin.
FlurazepamThe metabolism of Flurazepam can be increased when combined with Rifampicin.
FlurazepamThe serum concentration of Rifampicin can be increased when it is combined with Flurazepam.
FlurbiprofenThe metabolism of Flurbiprofen can be increased when combined with Rifampicin.
FlutamideThe metabolism of Flutamide can be increased when combined with Rifampicin.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be decreased when it is combined with Rifampicin.
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be decreased when it is combined with Rifampicin.
FluvastatinThe metabolism of Fluvastatin can be increased when combined with Rifampicin.
FluvoxamineThe metabolism of Rifampicin can be decreased when combined with Fluvoxamine.
FormoterolThe metabolism of Formoterol can be increased when combined with Rifampicin.
FosamprenavirThe serum concentration of Fosamprenavir can be decreased when it is combined with Rifampicin.
FosamprenavirThe metabolism of Rifampicin can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Rifampicin can be increased when it is combined with Fosaprepitant.
FosaprepitantThe serum concentration of Fosaprepitant can be decreased when it is combined with Rifampicin.
FosphenytoinThe serum concentration of Fosphenytoin can be decreased when it is combined with Rifampicin.
FosphenytoinThe metabolism of Rifampicin can be increased when combined with Fosphenytoin.
FrovatriptanThe metabolism of Frovatriptan can be increased when combined with Rifampicin.
FulvestrantThe metabolism of Fulvestrant can be increased when combined with Rifampicin.
Fusidic AcidThe serum concentration of Rifampicin can be increased when it is combined with Fusidic Acid.
GalantamineThe metabolism of Galantamine can be increased when combined with Rifampicin.
GavestinelThe metabolism of Gavestinel can be increased when combined with Rifampicin.
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Rifampicin.
GefitinibThe serum concentration of Rifampicin can be increased when it is combined with Gefitinib.
GemcitabineThe serum concentration of Gemcitabine can be decreased when it is combined with Rifampicin.
GemfibrozilThe metabolism of Gemfibrozil can be increased when combined with Rifampicin.
GenisteinThe serum concentration of Rifampicin can be increased when it is combined with Genistein.
GenisteinThe metabolism of Genistein can be increased when combined with Rifampicin.
GlibornurideThe serum concentration of Glibornuride can be decreased when it is combined with Rifampicin.
GliclazideThe serum concentration of Gliclazide can be decreased when it is combined with Rifampicin.
GlimepirideThe serum concentration of Glimepiride can be decreased when it is combined with Rifampicin.
GlipizideThe serum concentration of Glipizide can be decreased when it is combined with Rifampicin.
GliquidoneThe serum concentration of Gliquidone can be decreased when it is combined with Rifampicin.
GlisoxepideThe serum concentration of Glisoxepide can be decreased when it is combined with Rifampicin.
GlucosamineThe metabolism of Glucosamine can be increased when combined with Rifampicin.
GlyburideThe serum concentration of Glyburide can be decreased when it is combined with Rifampicin.
GlyburideThe serum concentration of Rifampicin can be increased when it is combined with Glyburide.
GlycerolThe serum concentration of Rifampicin can be increased when it is combined with Glycerol.
Gramicidin DThe serum concentration of Rifampicin can be increased when it is combined with Gramicidin D.
GranisetronThe metabolism of Granisetron can be increased when combined with Rifampicin.
GrazoprevirThe serum concentration of Grazoprevir can be decreased when it is combined with Rifampicin.
GrepafloxacinThe serum concentration of Grepafloxacin can be decreased when it is combined with Rifampicin.
GrepafloxacinThe serum concentration of Rifampicin can be increased when it is combined with Grepafloxacin.
GuanabenzThe metabolism of Guanabenz can be increased when combined with Rifampicin.
GuanfacineThe serum concentration of Guanfacine can be decreased when it is combined with Rifampicin.
HalofantrineThe metabolism of Halofantrine can be increased when combined with Rifampicin.
HaloperidolThe serum concentration of Haloperidol can be decreased when it is combined with Rifampicin.
HaloperidolThe serum concentration of Rifampicin can be increased when it is combined with Haloperidol.
HalothaneThe metabolism of Halothane can be increased when combined with Rifampicin.
HesperetinThe metabolism of Hesperetin can be increased when combined with Rifampicin.
HexobarbitalThe metabolism of Hexobarbital can be increased when combined with Rifampicin.
Histamine PhosphateThe metabolism of Histamine Phosphate can be increased when combined with Rifampicin.
HydrocodoneThe serum concentration of Hydrocodone can be decreased when it is combined with Rifampicin.
HydrocortisoneThe serum concentration of Hydrocortisone can be decreased when it is combined with Rifampicin.
HydrocortisoneThe serum concentration of Rifampicin can be increased when it is combined with Hydrocortisone.
HydromorphoneThe metabolism of Hydromorphone can be increased when combined with Rifampicin.
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be increased when combined with Rifampicin.
IbrutinibThe serum concentration of Ibrutinib can be decreased when it is combined with Rifampicin.
IbuprofenThe serum concentration of Ibuprofen can be decreased when it is combined with Rifampicin.
IdarubicinThe metabolism of Idarubicin can be increased when combined with Rifampicin.
IdelalisibThe serum concentration of Rifampicin can be increased when it is combined with Idelalisib.
IdelalisibThe serum concentration of Idelalisib can be decreased when it is combined with Rifampicin.
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be increased when Ifosfamide is used in combination with Rifampicin.
IloperidoneThe metabolism of Iloperidone can be increased when combined with Rifampicin.
ImatinibThe metabolism of Rifampicin can be decreased when combined with Imatinib.
ImatinibThe serum concentration of Imatinib can be decreased when it is combined with Rifampicin.
ImipramineThe serum concentration of Imipramine can be decreased when it is combined with Rifampicin.
ImipramineThe serum concentration of Rifampicin can be increased when it is combined with Imipramine.
ImiquimodThe metabolism of Imiquimod can be increased when combined with Rifampicin.
IndacaterolThe serum concentration of Indacaterol can be decreased when it is combined with Rifampicin.
IndapamideThe metabolism of Indapamide can be increased when combined with Rifampicin.
IndinavirThe serum concentration of Indinavir can be decreased when it is combined with Rifampicin.
indisulamThe metabolism of indisulam can be increased when combined with Rifampicin.
IndomethacinThe serum concentration of Indomethacin can be decreased when it is combined with Rifampicin.
IndomethacinThe serum concentration of Rifampicin can be increased when it is combined with Indomethacin.
Ipratropium bromideThe metabolism of Ipratropium bromide can be increased when combined with Rifampicin.
IrbesartanThe metabolism of Rifampicin can be decreased when combined with Irbesartan.
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be reduced when Irinotecan is used in combination with Rifampicin resulting in a loss in efficacy.
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Rifampicin resulting in a loss in efficacy.
IsavuconazoniumThe metabolism of Rifampicin can be decreased when combined with Isavuconazonium.
IsofluraneThe metabolism of Isoflurane can be increased when combined with Rifampicin.
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be increased when combined with Rifampicin.
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be increased when combined with Rifampicin.
IsradipineThe metabolism of Isradipine can be increased when combined with Rifampicin.
ItraconazoleThe serum concentration of Itraconazole can be decreased when it is combined with Rifampicin.
ItraconazoleThe serum concentration of Rifampicin can be increased when it is combined with Itraconazole.
IvabradineThe serum concentration of Ivabradine can be decreased when it is combined with Rifampicin.
IvacaftorThe serum concentration of Rifampicin can be increased when it is combined with Ivacaftor.
IvacaftorThe serum concentration of Ivacaftor can be decreased when it is combined with Rifampicin.
IvermectinThe serum concentration of Ivermectin can be decreased when it is combined with Rifampicin.
IvermectinThe serum concentration of Rifampicin can be increased when it is combined with Ivermectin.
IxabepiloneThe serum concentration of Ixabepilone can be decreased when it is combined with Rifampicin.
IxazomibThe serum concentration of Ixazomib can be decreased when it is combined with Rifampicin.
KetamineThe metabolism of Ketamine can be increased when combined with Rifampicin.
KetamineThe serum concentration of Rifampicin can be increased when it is combined with Ketamine.
KetazolamThe serum concentration of Ketazolam can be decreased when it is combined with Rifampicin.
KetobemidoneThe metabolism of Ketobemidone can be increased when combined with Rifampicin.
KetoconazoleThe serum concentration of Ketoconazole can be decreased when it is combined with Rifampicin.
KetoconazoleThe serum concentration of Rifampicin can be increased when it is combined with Ketoconazole.
KetoprofenThe metabolism of Ketoprofen can be increased when combined with Rifampicin.
LamivudineThe serum concentration of Lamivudine can be decreased when it is combined with Rifampicin.
LamotrigineThe metabolism of Lamotrigine can be increased when combined with Rifampicin.
LansoprazoleThe serum concentration of Lansoprazole can be decreased when it is combined with Rifampicin.
LansoprazoleThe serum concentration of Rifampicin can be increased when it is combined with Lansoprazole.
LapatinibThe serum concentration of Lapatinib can be decreased when it is combined with Rifampicin.
LapatinibThe serum concentration of Rifampicin can be increased when it is combined with Lapatinib.
LaquinimodThe metabolism of Laquinimod can be increased when combined with Rifampicin.
LedipasvirThe serum concentration of Ledipasvir can be decreased when it is combined with Rifampicin.
LeflunomideThe serum concentration of the active metabolites of Leflunomide can be increased when Leflunomide is used in combination with Rifampicin.
LeflunomideThe metabolism of Rifampicin can be decreased when combined with Leflunomide.
LenalidomideThe serum concentration of Lenalidomide can be decreased when it is combined with Rifampicin.
LenvatinibThe serum concentration of Lenvatinib can be decreased when it is combined with Rifampicin.
LercanidipineThe metabolism of Lercanidipine can be increased when combined with Rifampicin.
LesinuradThe metabolism of Lesinurad can be increased when combined with Rifampicin.
LetrozoleThe metabolism of Letrozole can be increased when combined with Rifampicin.
LevetiracetamThe serum concentration of Levetiracetam can be decreased when it is combined with Rifampicin.
LevobupivacaineThe metabolism of Levobupivacaine can be increased when combined with Rifampicin.
LevocetirizineThe metabolism of Levocetirizine can be increased when combined with Rifampicin.
LevofloxacinThe serum concentration of Levofloxacin can be decreased when it is combined with Rifampicin.
LevofloxacinThe serum concentration of Rifampicin can be increased when it is combined with Levofloxacin.
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be increased when combined with Rifampicin.
LevomilnacipranThe serum concentration of Levomilnacipran can be decreased when it is combined with Rifampicin.
LevonorgestrelThe metabolism of Levonorgestrel can be increased when combined with Rifampicin.
LevothyroxineThe serum concentration of Levothyroxine can be decreased when it is combined with Rifampicin.
LicofeloneThe metabolism of Licofelone can be increased when combined with Rifampicin.
LidocaineThe metabolism of Lidocaine can be increased when combined with Rifampicin.
LidocaineThe serum concentration of Rifampicin can be increased when it is combined with Lidocaine.
LinagliptinThe serum concentration of Linagliptin can be decreased when it is combined with Rifampicin.
LiothyronineThe serum concentration of Liothyronine can be decreased when it is combined with Rifampicin.
LiotrixThe serum concentration of Liotrix can be decreased when it is combined with Rifampicin.
LisinoprilThe serum concentration of Rifampicin can be increased when it is combined with Lisinopril.
LisurideThe metabolism of Lisuride can be increased when combined with Rifampicin.
LomefloxacinThe metabolism of Lomefloxacin can be increased when combined with Rifampicin.
LomitapideThe metabolism of Lomitapide can be increased when combined with Rifampicin.
LomitapideThe serum concentration of Rifampicin can be increased when it is combined with Lomitapide.
LoperamideThe serum concentration of Loperamide can be decreased when it is combined with Rifampicin.
LoperamideThe serum concentration of Rifampicin can be increased when it is combined with Loperamide.
LopinavirThe risk or severity of adverse effects can be increased when Rifampicin is combined with Lopinavir.
LopinavirThe serum concentration of Rifampicin can be increased when it is combined with Lopinavir.
LoratadineThe metabolism of Loratadine can be increased when combined with Rifampicin.
LoratadineThe serum concentration of Rifampicin can be increased when it is combined with Loratadine.
LorcaserinThe metabolism of Lorcaserin can be increased when combined with Rifampicin.
LornoxicamThe metabolism of Lornoxicam can be increased when combined with Rifampicin.
LosartanThe serum concentration of Losartan can be decreased when it is combined with Rifampicin.
LosartanThe serum concentration of Rifampicin can be increased when it is combined with Losartan.
LovastatinThe metabolism of Lovastatin can be increased when combined with Rifampicin.
LuliconazoleThe serum concentration of Rifampicin can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Rifampicin can be decreased when it is combined with Lumacaftor.
LumefantrineThe serum concentration of Lumefantrine can be decreased when it is combined with Rifampicin.
LumiracoxibThe metabolism of Lumiracoxib can be increased when combined with Rifampicin.
LurasidoneThe serum concentration of Lurasidone can be decreased when it is combined with Rifampicin.
MacitentanThe serum concentration of Macitentan can be decreased when it is combined with Rifampicin.
MalathionThe metabolism of Malathion can be increased when combined with Rifampicin.
MannitolThe serum concentration of Mannitol can be decreased when it is combined with Rifampicin.
MaprotilineThe serum concentration of Rifampicin can be increased when it is combined with Maprotiline.
MaprotilineThe metabolism of Maprotiline can be increased when combined with Rifampicin.
MaravirocThe serum concentration of Maraviroc can be decreased when it is combined with Rifampicin.
MebendazoleThe metabolism of Mebendazole can be increased when combined with Rifampicin.
MebendazoleThe serum concentration of Rifampicin can be increased when it is combined with Mebendazole.
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be increased when combined with Rifampicin.
MedrysoneThe serum concentration of Medrysone can be decreased when it is combined with Rifampicin.
Mefenamic acidThe metabolism of Mefenamic acid can be increased when combined with Rifampicin.
MefloquineThe metabolism of Mefloquine can be increased when combined with Rifampicin.
MefloquineThe serum concentration of Rifampicin can be increased when it is combined with Mefloquine.
Megestrol acetateThe serum concentration of Rifampicin can be increased when it is combined with Megestrol acetate.
MelatoninThe metabolism of Melatonin can be increased when combined with Rifampicin.
MelengestrolThe serum concentration of Melengestrol can be decreased when it is combined with Rifampicin.
MeloxicamThe metabolism of Meloxicam can be increased when combined with Rifampicin.
MenadioneThe metabolism of Menadione can be increased when combined with Rifampicin.
MephenytoinThe metabolism of Mephenytoin can be increased when combined with Rifampicin.
MeprobamateThe serum concentration of Rifampicin can be increased when it is combined with Meprobamate.
MeprobamateThe metabolism of Meprobamate can be increased when combined with Rifampicin.
MestranolThe metabolism of Mestranol can be increased when combined with Rifampicin.
MethadoneThe metabolism of Methadone can be increased when combined with Rifampicin.
MethadoneThe serum concentration of Rifampicin can be increased when it is combined with Methadone.
MethaqualoneThe metabolism of Methaqualone can be increased when combined with Rifampicin.
MethotrexateThe serum concentration of Methotrexate can be decreased when it is combined with Rifampicin.
MethoxsalenThe metabolism of Methoxsalen can be increased when combined with Rifampicin.
MethoxyfluraneThe metabolism of Methoxyflurane can be increased when combined with Rifampicin.
MethsuximideThe metabolism of Methsuximide can be increased when combined with Rifampicin.
MethylphenobarbitalThe metabolism of Methylphenobarbital can be increased when combined with Rifampicin.
MethylprednisoloneThe serum concentration of Methylprednisolone can be decreased when it is combined with Rifampicin.
MethyltestosteroneThe metabolism of Methyltestosterone can be increased when combined with Rifampicin.
MetoprololThe serum concentration of Metoprolol can be decreased when it is combined with Rifampicin.
MetoprololThe serum concentration of Rifampicin can be increased when it is combined with Metoprolol.
MetronidazoleThe metabolism of Metronidazole can be increased when combined with Rifampicin.
MexiletineThe metabolism of Mexiletine can be increased when combined with Rifampicin.
MianserinThe metabolism of Mianserin can be increased when combined with Rifampicin.
MibefradilThe metabolism of Mibefradil can be increased when combined with Rifampicin.
MibefradilThe serum concentration of Rifampicin can be increased when it is combined with Mibefradil.
MiconazoleThe metabolism of Miconazole can be increased when combined with Rifampicin.
MiconazoleThe serum concentration of Rifampicin can be increased when it is combined with Miconazole.
MidazolamThe serum concentration of Midazolam can be decreased when it is combined with Rifampicin.
MifepristoneThe serum concentration of Mifepristone can be decreased when it is combined with Rifampicin.
MifepristoneThe metabolism of Rifampicin can be decreased when combined with Mifepristone.
MirabegronThe serum concentration of Mirabegron can be decreased when it is combined with Rifampicin.
MirtazapineThe metabolism of Mirtazapine can be increased when combined with Rifampicin.
MitomycinThe serum concentration of Rifampicin can be increased when it is combined with Mitomycin.
MitotaneThe serum concentration of Rifampicin can be decreased when it is combined with Mitotane.
MitoxantroneThe serum concentration of Mitoxantrone can be decreased when it is combined with Rifampicin.
MoclobemideThe metabolism of Moclobemide can be increased when combined with Rifampicin.
ModafinilThe serum concentration of Rifampicin can be decreased when it is combined with Modafinil.
ModafinilThe metabolism of Modafinil can be increased when combined with Rifampicin.
MometasoneThe serum concentration of Mometasone can be decreased when it is combined with Rifampicin.
MontelukastThe metabolism of Montelukast can be increased when combined with Rifampicin.
MorphineThe serum concentration of Morphine can be decreased when it is combined with Rifampicin.
MorphineThe serum concentration of Rifampicin can be increased when it is combined with Morphine.
muraglitazarThe metabolism of muraglitazar can be increased when combined with Rifampicin.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be decreased when it is combined with Rifampicin.
NabumetoneThe metabolism of Nabumetone can be increased when combined with Rifampicin.
NadololThe serum concentration of Nadolol can be decreased when it is combined with Rifampicin.
NafcillinThe serum concentration of Rifampicin can be decreased when it is combined with Nafcillin.
NaloxegolThe serum concentration of Naloxegol can be decreased when it is combined with Rifampicin.
NaloxoneThe serum concentration of Naloxone can be decreased when it is combined with Rifampicin.
NaltrexoneThe serum concentration of Rifampicin can be increased when it is combined with Naltrexone.
NaproxenThe metabolism of Naproxen can be increased when combined with Rifampicin.
NaringeninThe serum concentration of Rifampicin can be increased when it is combined with Naringenin.
NateglinideThe metabolism of Nateglinide can be increased when combined with Rifampicin.
NefazodoneThe metabolism of Nefazodone can be increased when combined with Rifampicin.
NefazodoneThe serum concentration of Rifampicin can be decreased when it is combined with Nefazodone.
NelfinavirThe serum concentration of Nelfinavir can be decreased when it is combined with Rifampicin.
NeostigmineThe serum concentration of Rifampicin can be increased when it is combined with Neostigmine.
NetupitantThe serum concentration of Rifampicin can be increased when it is combined with Netupitant.
NetupitantThe serum concentration of Netupitant can be decreased when it is combined with Rifampicin.
NevirapineThe serum concentration of Nevirapine can be decreased when it is combined with Rifampicin.
NevirapineThe metabolism of Rifampicin can be decreased when combined with Nevirapine.
NicardipineThe serum concentration of Nicardipine can be decreased when it is combined with Rifampicin.
NicardipineThe serum concentration of Rifampicin can be increased when it is combined with Nicardipine.
NiclosamideThe metabolism of Niclosamide can be increased when combined with Rifampicin.
NicotineThe metabolism of Nicotine can be increased when combined with Rifampicin.
NifedipineThe serum concentration of Nifedipine can be decreased when it is combined with Rifampicin.
NilotinibThe serum concentration of Nilotinib can be decreased when it is combined with Rifampicin.
NilotinibThe metabolism of Rifampicin can be decreased when combined with Nilotinib.
NilutamideThe metabolism of Nilutamide can be increased when combined with Rifampicin.
NilvadipineThe metabolism of Nilvadipine can be increased when combined with Rifampicin.
NimodipineThe serum concentration of Nimodipine can be decreased when it is combined with Rifampicin.
NintedanibThe serum concentration of Nintedanib can be decreased when it is combined with Rifampicin.
NisoldipineThe serum concentration of Nisoldipine can be decreased when it is combined with Rifampicin.
NisoldipineThe serum concentration of Rifampicin can be increased when it is combined with Nisoldipine.
NitrazepamThe serum concentration of Nitrazepam can be decreased when it is combined with Rifampicin.
NitrazepamThe serum concentration of Rifampicin can be increased when it is combined with Nitrazepam.
NitrendipineThe metabolism of Nitrendipine can be increased when combined with Rifampicin.
NitrendipineThe serum concentration of Rifampicin can be increased when it is combined with Nitrendipine.
Nitric OxideThe metabolism of Nitric Oxide can be increased when combined with Rifampicin.
NizatidineThe serum concentration of Nizatidine can be decreased when it is combined with Rifampicin.
NorethisteroneThe metabolism of Norethisterone can be increased when combined with Rifampicin.
NorethisteroneThe serum concentration of Rifampicin can be decreased when it is combined with Norethisterone.
NorgestrelThe metabolism of Norgestrel can be increased when combined with Rifampicin.
NortriptylineThe metabolism of Nortriptyline can be increased when combined with Rifampicin.
OlanzapineThe serum concentration of Olanzapine can be decreased when it is combined with Rifampicin.
OlaparibThe serum concentration of Olaparib can be decreased when it is combined with Rifampicin.
OlaparibThe metabolism of Rifampicin can be decreased when combined with Olaparib.
OlodaterolThe metabolism of Olodaterol can be increased when combined with Rifampicin.
OlopatadineThe metabolism of Olopatadine can be increased when combined with Rifampicin.
OmbitasvirThe serum concentration of Ombitasvir can be decreased when it is combined with Rifampicin.
OmeprazoleThe serum concentration of Omeprazole can be decreased when it is combined with Rifampicin.
OmeprazoleThe serum concentration of Rifampicin can be increased when it is combined with Omeprazole.
OndansetronThe metabolism of Ondansetron can be increased when combined with Rifampicin.
OrphenadrineThe metabolism of Orphenadrine can be increased when combined with Rifampicin.
OsimertinibThe serum concentration of Rifampicin can be increased when it is combined with Osimertinib.
OsimertinibThe serum concentration of Osimertinib can be decreased when it is combined with Rifampicin.
OspemifeneThe metabolism of Ospemifene can be increased when combined with Rifampicin.
OxaliplatinThe metabolism of Oxaliplatin can be increased when combined with Rifampicin.
OxaprozinThe metabolism of Oxaprozin can be increased when combined with Rifampicin.
OxazepamThe metabolism of Oxazepam can be increased when combined with Rifampicin.
OxiconazoleThe metabolism of Oxiconazole can be increased when combined with Rifampicin.
OxtriphyllineThe metabolism of Oxtriphylline can be increased when combined with Rifampicin.
OxybutyninThe metabolism of Oxybutynin can be increased when combined with Rifampicin.
OxycodoneThe serum concentration of Oxycodone can be decreased when it is combined with Rifampicin.
OxymorphoneThe metabolism of Oxymorphone can be increased when combined with Rifampicin.
P-NitrophenolThe serum concentration of Rifampicin can be increased when it is combined with P-Nitrophenol.
PaclitaxelThe serum concentration of Paclitaxel can be decreased when it is combined with Rifampicin.
PaclitaxelThe serum concentration of Rifampicin can be increased when it is combined with Paclitaxel.
PalbociclibThe serum concentration of Rifampicin can be increased when it is combined with Palbociclib.
PalbociclibThe serum concentration of Palbociclib can be decreased when it is combined with Rifampicin.
Palmitic AcidThe serum concentration of Rifampicin can be increased when it is combined with Palmitic Acid.
PalonosetronThe metabolism of Palonosetron can be increased when combined with Rifampicin.
PanobinostatThe serum concentration of Panobinostat can be decreased when it is combined with Rifampicin.
PantoprazoleThe metabolism of Pantoprazole can be increased when combined with Rifampicin.
PantoprazoleThe serum concentration of Rifampicin can be increased when it is combined with Pantoprazole.
ParamethadioneThe metabolism of Paramethadione can be increased when combined with Rifampicin.
ParamethasoneThe serum concentration of Paramethasone can be decreased when it is combined with Rifampicin.
ParecoxibThe metabolism of Parecoxib can be increased when combined with Rifampicin.
ParicalcitolThe metabolism of Paricalcitol can be increased when combined with Rifampicin.
ParitaprevirThe metabolism of Paritaprevir can be increased when combined with Rifampicin.
ParoxetineThe serum concentration of Rifampicin can be increased when it is combined with Paroxetine.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Rifampicin.
PentamidineThe metabolism of Pentamidine can be increased when combined with Rifampicin.
PentobarbitalThe metabolism of Rifampicin can be increased when combined with Pentobarbital.
PentoxifyllineThe metabolism of Pentoxifylline can be increased when combined with Rifampicin.
PerampanelThe serum concentration of Perampanel can be decreased when it is combined with Rifampicin.
PergolideThe metabolism of Pergolide can be increased when combined with Rifampicin.
PerhexilineThe metabolism of Perhexiline can be increased when combined with Rifampicin.
PerindoprilThe serum concentration of Rifampicin can be increased when it is combined with Perindopril.
PermethrinThe metabolism of Permethrin can be increased when combined with Rifampicin.
PerphenazineThe metabolism of Perphenazine can be increased when combined with Rifampicin.
PethidineThe metabolism of Pethidine can be increased when combined with Rifampicin.
PhenacetinThe metabolism of Phenacetin can be increased when combined with Rifampicin.
PhenobarbitalThe serum concentration of Phenobarbital can be decreased when it is combined with Rifampicin.
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be increased when combined with Rifampicin.
PhenprocoumonThe metabolism of Phenprocoumon can be increased when combined with Rifampicin.
PhenylbutazoneThe metabolism of Phenylbutazone can be increased when combined with Rifampicin.
PhenytoinThe metabolism of Rifampicin can be increased when combined with Phenytoin.
PhenytoinThe serum concentration of Phenytoin can be decreased when it is combined with Rifampicin.
Picosulfuric acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Rifampicin.
PilocarpineThe metabolism of Pilocarpine can be increased when combined with Rifampicin.
PimecrolimusThe metabolism of Pimecrolimus can be increased when combined with Rifampicin.
PimozideThe metabolism of Pimozide can be increased when combined with Rifampicin.
PimozideThe serum concentration of Rifampicin can be increased when it is combined with Pimozide.
PinacidilThe metabolism of Pinacidil can be increased when combined with Rifampicin.
PioglitazoneThe metabolism of Pioglitazone can be increased when combined with Rifampicin.
PipotiazineThe metabolism of Pipotiazine can be increased when combined with Rifampicin.
PirfenidoneThe serum concentration of Pirfenidone can be decreased when it is combined with Rifampicin.
PiroxicamThe metabolism of Piroxicam can be increased when combined with Rifampicin.
PitavastatinThe serum concentration of Pitavastatin can be decreased when it is combined with Rifampicin.
Platelet Activating FactorThe serum concentration of Rifampicin can be decreased when it is combined with Platelet Activating Factor.
PodofiloxThe metabolism of Podofilox can be increased when combined with Rifampicin.
PomalidomideThe serum concentration of Pomalidomide can be decreased when it is combined with Rifampicin.
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with Rifampicin.
PonatinibThe serum concentration of Rifampicin can be increased when it is combined with Ponatinib.
PosaconazoleThe metabolism of Posaconazole can be increased when combined with Rifampicin.
PosaconazoleThe serum concentration of Rifampicin can be increased when it is combined with Posaconazole.
PrasugrelRifampicin may decrease the antiplatelet activities of Prasugrel.
PravastatinThe serum concentration of Pravastatin can be decreased when it is combined with Rifampicin.
PravastatinThe serum concentration of Rifampicin can be increased when it is combined with Pravastatin.
PrazepamThe metabolism of Prazepam can be increased when combined with Rifampicin.
PraziquantelThe serum concentration of Praziquantel can be decreased when it is combined with Rifampicin.
PrazosinThe serum concentration of Prazosin can be decreased when it is combined with Rifampicin.
PrazosinThe serum concentration of Rifampicin can be increased when it is combined with Prazosin.
PrednicarbateThe serum concentration of Prednicarbate can be decreased when it is combined with Rifampicin.
PrednisoloneThe serum concentration of Prednisolone can be decreased when it is combined with Rifampicin.
PrednisoneThe serum concentration of Prednisone can be decreased when it is combined with Rifampicin.
PrednisoneThe serum concentration of Rifampicin can be increased when it is combined with Prednisone.
PregnenoloneThe serum concentration of Pregnenolone can be decreased when it is combined with Rifampicin.
PrimaquineThe metabolism of Primaquine can be increased when combined with Rifampicin.
PrimidoneThe metabolism of Rifampicin can be increased when combined with Primidone.
ProbenecidThe serum concentration of Rifampicin can be increased when it is combined with Probenecid.
ProchlorperazineThe metabolism of Prochlorperazine can be increased when combined with Rifampicin.
ProgesteroneThe serum concentration of Progesterone can be decreased when it is combined with Rifampicin.
ProguanilThe metabolism of Proguanil can be increased when combined with Rifampicin.
PromazineThe metabolism of Promazine can be increased when combined with Rifampicin.
PromethazineThe serum concentration of Rifampicin can be increased when it is combined with Promethazine.
PromethazineThe metabolism of Promethazine can be increased when combined with Rifampicin.
PropafenoneThe serum concentration of Propafenone can be decreased when it is combined with Rifampicin.
PropafenoneThe serum concentration of Rifampicin can be increased when it is combined with Propafenone.
PropofolRifampicin may increase the hypotensive activities of Propofol.
PropranololThe serum concentration of Propranolol can be decreased when it is combined with Rifampicin.
PropranololThe serum concentration of Rifampicin can be increased when it is combined with Propranolol.
ProtriptylineThe serum concentration of Rifampicin can be increased when it is combined with Protriptyline.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Rifampicin.
PyrazinamidePyrazinamide may increase the hepatotoxic activities of Rifampicin.
PyrazinamideThe metabolism of Pyrazinamide can be increased when combined with Rifampicin.
PyrimethamineThe metabolism of Rifampicin can be decreased when combined with Pyrimethamine.
QuazepamThe metabolism of Quazepam can be increased when combined with Rifampicin.
QuercetinThe serum concentration of Rifampicin can be increased when it is combined with Quercetin.
QuetiapineThe serum concentration of Quetiapine can be decreased when it is combined with Rifampicin.
QuinacrineThe metabolism of Quinacrine can be increased when combined with Rifampicin.
QuinacrineThe serum concentration of Rifampicin can be increased when it is combined with Quinacrine.
QuinidineThe serum concentration of Quinidine can be decreased when it is combined with Rifampicin.
QuinidineThe serum concentration of Rifampicin can be increased when it is combined with Quinidine.
QuinineThe serum concentration of Quinine can be decreased when it is combined with Rifampicin.
QuinineThe serum concentration of Rifampicin can be increased when it is combined with Quinine.
RabeprazoleThe metabolism of Rabeprazole can be increased when combined with Rifampicin.
RaloxifeneThe metabolism of Raloxifene can be increased when combined with Rifampicin.
RaltegravirThe serum concentration of Raltegravir can be decreased when it is combined with Rifampicin.
RamelteonThe metabolism of Ramelteon can be increased when combined with Rifampicin.
RanitidineThe serum concentration of Ranitidine can be decreased when it is combined with Rifampicin.
RanitidineThe serum concentration of Rifampicin can be increased when it is combined with Ranitidine.
RanolazineThe serum concentration of Rifampicin can be increased when it is combined with Ranolazine.
RanolazineThe serum concentration of Ranolazine can be decreased when it is combined with Rifampicin.
RasagilineThe metabolism of Rasagiline can be increased when combined with Rifampicin.
ReboxetineThe metabolism of Reboxetine can be increased when combined with Rifampicin.
ReboxetineThe serum concentration of Rifampicin can be increased when it is combined with Reboxetine.
RegorafenibThe serum concentration of Regorafenib can be decreased when it is combined with Rifampicin.
RegorafenibThe serum concentration of Rifampicin can be increased when it is combined with Regorafenib.
RepaglinideThe serum concentration of Repaglinide can be decreased when it is combined with Rifampicin.
ReserpineThe serum concentration of Reserpine can be decreased when it is combined with Rifampicin.
ResveratrolThe metabolism of Resveratrol can be increased when combined with Rifampicin.
RetapamulinThe metabolism of Retapamulin can be increased when combined with Rifampicin.
RifabutinThe metabolism of Rifampicin can be increased when combined with Rifabutin.
RifapentineThe metabolism of Rifampicin can be increased when combined with Rifapentine.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Rifampicin.
RilpivirineThe metabolism of Rilpivirine can be increased when combined with Rifampicin.
RilpivirineThe serum concentration of Rifampicin can be increased when it is combined with Rilpivirine.
RiluzoleThe metabolism of Riluzole can be increased when combined with Rifampicin.
RimexoloneThe serum concentration of Rimexolone can be decreased when it is combined with Rifampicin.
RimonabantThe metabolism of Rimonabant can be increased when combined with Rifampicin.
RiociguatThe metabolism of Riociguat can be increased when combined with Rifampicin.
RisperidoneThe serum concentration of Risperidone can be decreased when it is combined with Rifampicin.
RitonavirThe serum concentration of Ritonavir can be decreased when it is combined with Rifampicin.
RivaroxabanThe serum concentration of Rivaroxaban can be decreased when it is combined with Rifampicin.
RizatriptanThe metabolism of Rizatriptan can be increased when combined with Rifampicin.
RofecoxibThe metabolism of Rofecoxib can be increased when combined with Rifampicin.
RoflumilastThe serum concentration of Roflumilast can be decreased when it is combined with Rifampicin.
RolapitantThe serum concentration of Rolapitant can be decreased when it is combined with Rifampicin.
RolapitantThe serum concentration of Rifampicin can be increased when it is combined with Rolapitant.
RomidepsinThe serum concentration of Romidepsin can be decreased when it is combined with Rifampicin.
RopiniroleThe metabolism of Ropinirole can be increased when combined with Rifampicin.
RopivacaineThe metabolism of Ropivacaine can be increased when combined with Rifampicin.
RosiglitazoneThe metabolism of Rosiglitazone can be increased when combined with Rifampicin.
RosuvastatinThe metabolism of Rosuvastatin can be increased when combined with Rifampicin.
RotigotineThe metabolism of Rotigotine can be increased when combined with Rifampicin.
RoxithromycinThe metabolism of Roxithromycin can be increased when combined with Rifampicin.
RuxolitinibThe metabolism of Ruxolitinib can be increased when combined with Rifampicin.
Salicylic acidThe serum concentration of Salicylic acid can be decreased when it is combined with Rifampicin.
SalmeterolThe metabolism of Salmeterol can be increased when combined with Rifampicin.
SaquinavirThe risk or severity of adverse effects can be increased when Rifampicin is combined with Saquinavir.
SaquinavirThe serum concentration of Rifampicin can be decreased when it is combined with Saquinavir.
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Rifampicin.
ScopolamineThe serum concentration of Rifampicin can be increased when it is combined with Scopolamine.
SecobarbitalThe metabolism of Rifampicin can be increased when combined with Secobarbital.
SelegilineThe metabolism of Selegiline can be increased when combined with Rifampicin.
SelegilineThe serum concentration of Rifampicin can be increased when it is combined with Selegiline.
SelexipagThe serum concentration of Selexipag can be decreased when it is combined with Rifampicin.
SeratrodastThe metabolism of Seratrodast can be increased when combined with Rifampicin.
SertindoleThe metabolism of Sertindole can be increased when combined with Rifampicin.
SertralineThe metabolism of Sertraline can be increased when combined with Rifampicin.
SertralineThe serum concentration of Rifampicin can be increased when it is combined with Sertraline.
SevofluraneThe metabolism of Sevoflurane can be increased when combined with Rifampicin.
SibutramineThe metabolism of Sibutramine can be increased when combined with Rifampicin.
SildenafilThe metabolism of Sildenafil can be increased when combined with Rifampicin.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Rifampicin.
SiltuximabThe serum concentration of Rifampicin can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Rifampicin can be increased when it is combined with Simeprevir.
SimeprevirThe serum concentration of Simeprevir can be decreased when it is combined with Rifampicin.
SimvastatinThe metabolism of Simvastatin can be increased when combined with Rifampicin.
SimvastatinThe serum concentration of Rifampicin can be increased when it is combined with Simvastatin.
SirolimusThe metabolism of Sirolimus can be increased when combined with Rifampicin.
SirolimusThe serum concentration of Rifampicin can be decreased when it is combined with Sirolimus.
SitagliptinThe serum concentration of Sitagliptin can be decreased when it is combined with Rifampicin.
SitaxentanThe metabolism of Sitaxentan can be increased when combined with Rifampicin.
SofosbuvirThe serum concentration of Sofosbuvir can be decreased when it is combined with Rifampicin.
SolifenacinThe metabolism of Solifenacin can be increased when combined with Rifampicin.
SonidegibThe serum concentration of Sonidegib can be decreased when it is combined with Rifampicin.
SorafenibThe serum concentration of Sorafenib can be decreased when it is combined with Rifampicin.
SorafenibThe serum concentration of Rifampicin can be increased when it is combined with Sorafenib.
SparfloxacinThe serum concentration of Sparfloxacin can be decreased when it is combined with Rifampicin.
SphingosineThe serum concentration of Sphingosine can be decreased when it is combined with Rifampicin.
SpiramycinThe metabolism of Spiramycin can be increased when combined with Rifampicin.
SpironolactoneThe serum concentration of Rifampicin can be increased when it is combined with Spironolactone.
St. John's WortThe serum concentration of Rifampicin can be decreased when it is combined with St. John's Wort.
StaurosporineThe serum concentration of Rifampicin can be increased when it is combined with Staurosporine.
StiripentolThe serum concentration of Rifampicin can be increased when it is combined with Stiripentol.
StreptozocinThe serum concentration of Rifampicin can be decreased when it is combined with Streptozocin.
SufentanilThe metabolism of Sufentanil can be increased when combined with Rifampicin.
SulfadiazineThe metabolism of Sulfadiazine can be increased when combined with Rifampicin.
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be increased when combined with Rifampicin.
SulfamoxoleThe metabolism of Sulfamoxole can be increased when combined with Rifampicin.
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be increased when combined with Rifampicin.
SulfinpyrazoneThe serum concentration of Rifampicin can be increased when it is combined with Sulfinpyrazone.
SulfisoxazoleThe metabolism of Rifampicin can be decreased when combined with Sulfisoxazole.
SumatriptanThe serum concentration of Rifampicin can be increased when it is combined with Sumatriptan.
SunitinibThe serum concentration of Sunitinib can be decreased when it is combined with Rifampicin.
SunitinibThe serum concentration of Rifampicin can be increased when it is combined with Sunitinib.
SuprofenThe metabolism of Suprofen can be increased when combined with Rifampicin.
SuvorexantThe serum concentration of Suvorexant can be decreased when it is combined with Rifampicin.
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be increased when combined with Rifampicin.
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be increased when combined with Rifampicin.
TacrineThe serum concentration of Rifampicin can be increased when it is combined with Tacrine.
TacrineThe metabolism of Tacrine can be increased when combined with Rifampicin.
TacrolimusThe serum concentration of Tacrolimus can be decreased when it is combined with Rifampicin.
TadalafilThe serum concentration of Tadalafil can be decreased when it is combined with Rifampicin.
TamoxifenThe serum concentration of Tamoxifen can be decreased when it is combined with Rifampicin.
TamsulosinThe metabolism of Tamsulosin can be increased when combined with Rifampicin.
TapentadolThe metabolism of Tapentadol can be increased when combined with Rifampicin.
TasimelteonThe serum concentration of Tasimelteon can be decreased when it is combined with Rifampicin.
TasosartanThe metabolism of Tasosartan can be increased when combined with Rifampicin.
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be increased when combined with Rifampicin.
Taurocholic AcidThe serum concentration of Taurocholic Acid can be decreased when it is combined with Rifampicin.
Taurocholic AcidThe serum concentration of Rifampicin can be increased when it is combined with Taurocholic Acid.
TazaroteneThe metabolism of Tazarotene can be increased when combined with Rifampicin.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Rifampicin.
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Rifampicin.
TelaprevirThe metabolism of Rifampicin can be decreased when combined with Telaprevir.
TelithromycinThe metabolism of Telithromycin can be increased when combined with Rifampicin.
TelmisartanThe serum concentration of Rifampicin can be increased when it is combined with Telmisartan.
TemafloxacinThe metabolism of Temafloxacin can be increased when combined with Rifampicin.
TemazepamThe metabolism of Temazepam can be increased when combined with Rifampicin.
TemsirolimusThe serum concentration of Temsirolimus can be decreased when it is combined with Rifampicin.
TemsirolimusThe serum concentration of Rifampicin can be increased when it is combined with Temsirolimus.
TeniposideThe metabolism of Teniposide can be increased when combined with Rifampicin.
TenoxicamThe metabolism of Tenoxicam can be increased when combined with Rifampicin.
TerazosinThe serum concentration of Rifampicin can be increased when it is combined with Terazosin.
TerbinafineThe serum concentration of Terbinafine can be decreased when it is combined with Rifampicin.
TerfenadineThe metabolism of Terfenadine can be increased when combined with Rifampicin.
TerfenadineThe serum concentration of Rifampicin can be increased when it is combined with Terfenadine.
TeriflunomideThe metabolism of Rifampicin can be decreased when combined with Teriflunomide.
TesmilifeneThe metabolism of Tesmilifene can be increased when combined with Rifampicin.
TesmilifeneThe serum concentration of Rifampicin can be decreased when it is combined with Tesmilifene.
TestosteroneThe metabolism of Testosterone can be increased when combined with Rifampicin.
TestosteroneThe serum concentration of Rifampicin can be increased when it is combined with Testosterone.
TetracyclineThe metabolism of Tetracycline can be increased when combined with Rifampicin.
ThalidomideThe metabolism of Thalidomide can be increased when combined with Rifampicin.
TheobromineThe metabolism of Theobromine can be increased when combined with Rifampicin.
TheophyllineThe metabolism of Theophylline can be increased when combined with Rifampicin.
ThiabendazoleThe metabolism of Thiabendazole can be increased when combined with Rifampicin.
ThiamylalThe metabolism of Thiamylal can be increased when combined with Rifampicin.
ThioridazineThe metabolism of Thioridazine can be increased when combined with Rifampicin.
ThiotepaThe metabolism of Thiotepa can be increased when combined with Rifampicin.
ThiothixeneThe metabolism of Thiothixene can be increased when combined with Rifampicin.
Thyroid, porcineThe serum concentration of Thyroid, porcine can be decreased when it is combined with Rifampicin.
TiagabineThe metabolism of Tiagabine can be increased when combined with Rifampicin.
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Rifampicin resulting in a loss in efficacy.
TicagrelorThe serum concentration of Rifampicin can be increased when it is combined with Ticagrelor.
TiclopidineThe metabolism of Ticlopidine can be increased when combined with Rifampicin.
TimololThe serum concentration of Timolol can be decreased when it is combined with Rifampicin.
TinidazoleThe metabolism of Tinidazole can be increased when combined with Rifampicin.
TiotropiumThe metabolism of Tiotropium can be increased when combined with Rifampicin.
TipranavirThe serum concentration of Tipranavir can be decreased when it is combined with Rifampicin.
TixocortolThe serum concentration of Tixocortol can be decreased when it is combined with Rifampicin.
TizanidineThe metabolism of Tizanidine can be increased when combined with Rifampicin.
TocilizumabThe serum concentration of Rifampicin can be decreased when it is combined with Tocilizumab.
TofacitinibThe serum concentration of Tofacitinib can be decreased when it is combined with Rifampicin.
TolazamideThe serum concentration of Tolazamide can be decreased when it is combined with Rifampicin.
TolbutamideThe serum concentration of Tolbutamide can be decreased when it is combined with Rifampicin.
TolbutamideThe metabolism of Rifampicin can be decreased when combined with Tolbutamide.
TolterodineThe metabolism of Tolterodine can be increased when combined with Rifampicin.
TolvaptanThe serum concentration of Tolvaptan can be decreased when it is combined with Rifampicin.
TolvaptanThe serum concentration of Rifampicin can be increased when it is combined with Tolvaptan.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Rifampicin.
TorasemideThe metabolism of Torasemide can be increased when combined with Rifampicin.
ToremifeneThe serum concentration of Toremifene can be decreased when it is combined with Rifampicin.
TrabectedinThe serum concentration of Trabectedin can be decreased when it is combined with Rifampicin.
TramadolThe metabolism of Tramadol can be increased when combined with Rifampicin.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be decreased when it is combined with Rifampicin.
TrazodoneThe metabolism of Trazodone can be increased when combined with Rifampicin.
TrazodoneThe serum concentration of Rifampicin can be decreased when it is combined with Trazodone.
TreprostinilThe serum concentration of Treprostinil can be decreased when it is combined with Rifampicin.
TretinoinThe metabolism of Tretinoin can be increased when combined with Rifampicin.
TriamcinoloneThe serum concentration of Triamcinolone can be decreased when it is combined with Rifampicin.
TriamtereneThe metabolism of Triamterene can be increased when combined with Rifampicin.
TriazolamThe metabolism of Triazolam can be increased when combined with Rifampicin.
TrifluoperazineThe serum concentration of Rifampicin can be increased when it is combined with Trifluoperazine.
TrifluoperazineThe metabolism of Trifluoperazine can be increased when combined with Rifampicin.
TriflupromazineThe serum concentration of Rifampicin can be increased when it is combined with Triflupromazine.
TrimethadioneThe metabolism of Trimethadione can be increased when combined with Rifampicin.
TrimethoprimThe metabolism of Trimethoprim can be increased when combined with Rifampicin.
TrimethoprimThe serum concentration of Rifampicin can be decreased when it is combined with Trimethoprim.
TrimipramineThe metabolism of Trimipramine can be increased when combined with Rifampicin.
TrimipramineThe serum concentration of Rifampicin can be increased when it is combined with Trimipramine.
TroglitazoneThe metabolism of Troglitazone can be increased when combined with Rifampicin.
TroleandomycinThe metabolism of Troleandomycin can be increased when combined with Rifampicin.
TroleandomycinThe serum concentration of Rifampicin can be increased when it is combined with Troleandomycin.
UdenafilThe metabolism of Udenafil can be increased when combined with Rifampicin.
UlipristalThe serum concentration of Ulipristal can be decreased when it is combined with Rifampicin.
UmeclidiniumThe serum concentration of Umeclidinium can be decreased when it is combined with Rifampicin.
ValdecoxibThe metabolism of Valdecoxib can be increased when combined with Rifampicin.
Valproic AcidThe metabolism of Valproic Acid can be increased when combined with Rifampicin.
ValsartanThe metabolism of Rifampicin can be decreased when combined with Valsartan.
VandetanibThe serum concentration of Vandetanib can be decreased when it is combined with Rifampicin.
VanoxerineThe metabolism of Vanoxerine can be increased when combined with Rifampicin.
VardenafilThe metabolism of Vardenafil can be increased when combined with Rifampicin.
VecuroniumThe serum concentration of Vecuronium can be decreased when it is combined with Rifampicin.
VemurafenibThe serum concentration of Vemurafenib can be decreased when it is combined with Rifampicin.
VenlafaxineThe metabolism of Rifampicin can be decreased when combined with Venlafaxine.
VenlafaxineThe serum concentration of Venlafaxine can be decreased when it is combined with Rifampicin.
VerapamilThe metabolism of Rifampicin can be decreased when combined with Verapamil.
VerapamilThe serum concentration of Verapamil can be decreased when it is combined with Rifampicin.
VicrivirocThe metabolism of Vicriviroc can be increased when combined with Rifampicin.
VilanterolThe metabolism of Vilanterol can be increased when combined with Rifampicin.
VilazodoneThe serum concentration of Vilazodone can be decreased when it is combined with Rifampicin.
VinblastineThe serum concentration of Vinblastine can be decreased when it is combined with Rifampicin.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Rifampicin.
VincristineThe serum concentration of Rifampicin can be decreased when it is combined with Vincristine.
VindesineThe metabolism of Vindesine can be increased when combined with Rifampicin.
VinorelbineThe metabolism of Vinorelbine can be increased when combined with Rifampicin.
VinorelbineThe serum concentration of Rifampicin can be increased when it is combined with Vinorelbine.
VismodegibThe serum concentration of Vismodegib can be decreased when it is combined with Rifampicin.
VorapaxarThe serum concentration of Vorapaxar can be decreased when it is combined with Rifampicin.
VoriconazoleThe metabolism of Voriconazole can be increased when combined with Rifampicin.
VortioxetineThe serum concentration of Vortioxetine can be decreased when it is combined with Rifampicin.
WarfarinThe metabolism of Warfarin can be increased when combined with Rifampicin.
XimelagatranThe metabolism of Ximelagatran can be increased when combined with Rifampicin.
YohimbineThe metabolism of Yohimbine can be increased when combined with Rifampicin.
ZafirlukastThe metabolism of Zafirlukast can be increased when combined with Rifampicin.
ZalcitabineThe metabolism of Zalcitabine can be increased when combined with Rifampicin.
ZaleplonThe serum concentration of Zaleplon can be decreased when it is combined with Rifampicin.
ZaltoprofenThe metabolism of Zaltoprofen can be increased when combined with Rifampicin.
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Rifampicin.
ZileutonThe metabolism of Zileuton can be increased when combined with Rifampicin.
ZimelidineThe serum concentration of Rifampicin can be increased when it is combined with Zimelidine.
ZiprasidoneThe metabolism of Ziprasidone can be increased when combined with Rifampicin.
ZolmitriptanThe metabolism of Zolmitriptan can be increased when combined with Rifampicin.
ZolpidemThe metabolism of Zolpidem can be increased when combined with Rifampicin.
ZomepiracThe metabolism of Zomepirac can be increased when combined with Rifampicin.
ZonisamideThe metabolism of Zonisamide can be increased when combined with Rifampicin.
ZopicloneThe metabolism of Zopiclone can be increased when combined with Rifampicin.
ZuclopenthixolThe serum concentration of Zuclopenthixol can be decreased when it is combined with Rifampicin.
Food Interactions
  • Avoid alcohol.
  • Take on empty stomach: 1 hour before or 2 hours after meals.
  • Take with a full glass of water.

Targets

Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
yes
Actions
inhibitor
General Function:
Ribonucleoside binding
Specific Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Gene Name:
rpoB
Uniprot ID:
P0A8V2
Molecular Weight:
150631.165 Da
References
  1. Villain-Guillot P, Bastide L, Gualtieri M, Leonetti JP: Progress in targeting bacterial transcription. Drug Discov Today. 2007 Mar;12(5-6):200-8. Epub 2007 Feb 5. [PubMed:17331884 ]
  2. White RJ, Lancini GC, Silvestri LG: Mechanism of action of rifampin on Mycobacterium smegmatis. J Bacteriol. 1971 Nov;108(2):737-41. [PubMed:4942761 ]
  3. Tupin A, Gualtieri M, Roquet-Baneres F, Morichaud Z, Brodolin K, Leonetti JP: Resistance to rifampicin: at the crossroads between ecological, genomic and medical concerns. Int J Antimicrob Agents. 2010 Jun;35(6):519-23. doi: 10.1016/j.ijantimicag.2009.12.017. Epub 2010 Feb 24. [PubMed:20185278 ]
  4. Campbell EA, Korzheva N, Mustaev A, Murakami K, Nair S, Goldfarb A, Darst SA: Structural mechanism for rifampicin inhibition of bacterial rna polymerase. Cell. 2001 Mar 23;104(6):901-12. [PubMed:11290327 ]
  5. Wehrli W: Rifampin: mechanisms of action and resistance. Rev Infect Dis. 1983 Jul-Aug;5 Suppl 3:S407-11. [PubMed:6356275 ]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
yes
Actions
inhibitor
General Function:
Dna-directed rna polymerase activity
Specific Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Gene Name:
rpoC
Uniprot ID:
P0A8T7
Molecular Weight:
155158.84 Da
References
  1. Villain-Guillot P, Bastide L, Gualtieri M, Leonetti JP: Progress in targeting bacterial transcription. Drug Discov Today. 2007 Mar;12(5-6):200-8. Epub 2007 Feb 5. [PubMed:17331884 ]
  2. White RJ, Lancini GC, Silvestri LG: Mechanism of action of rifampin on Mycobacterium smegmatis. J Bacteriol. 1971 Nov;108(2):737-41. [PubMed:4942761 ]
  3. Tupin A, Gualtieri M, Roquet-Baneres F, Morichaud Z, Brodolin K, Leonetti JP: Resistance to rifampicin: at the crossroads between ecological, genomic and medical concerns. Int J Antimicrob Agents. 2010 Jun;35(6):519-23. doi: 10.1016/j.ijantimicag.2009.12.017. Epub 2010 Feb 24. [PubMed:20185278 ]
  4. Campbell EA, Korzheva N, Mustaev A, Murakami K, Nair S, Goldfarb A, Darst SA: Structural mechanism for rifampicin inhibition of bacterial rna polymerase. Cell. 2001 Mar 23;104(6):901-12. [PubMed:11290327 ]
  5. Wehrli W: Rifampin: mechanisms of action and resistance. Rev Infect Dis. 1983 Jul-Aug;5 Suppl 3:S407-11. [PubMed:6356275 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Zinc ion binding
Specific Function:
Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and is...
Gene Name:
NR1I2
Uniprot ID:
O75469
Molecular Weight:
49761.245 Da
References
  1. Chen J, Raymond K: Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor. Ann Clin Microbiol Antimicrob. 2006 Feb 15;5:3. [PubMed:16480505 ]
  2. Cheng J, Ma X, Krausz KW, Idle JR, Gonzalez FJ: Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity. Drug Metab Dispos. 2009 Aug;37(8):1611-21. doi: 10.1124/dmd.109.027565. Epub 2009 May 21. [PubMed:19460945 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B1
Uniprot ID:
Q9Y6L6
Molecular Weight:
76447.99 Da
References
  1. Vavricka SR, Van Montfoort J, Ha HR, Meier PJ, Fattinger K: Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology. 2002 Jul;36(1):164-72. [PubMed:12085361 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. Vavricka SR, Van Montfoort J, Ha HR, Meier PJ, Fattinger K: Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology. 2002 Jul;36(1):164-72. [PubMed:12085361 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B3
Uniprot ID:
Q9NPD5
Molecular Weight:
77402.175 Da
References
  1. Vavricka SR, Van Montfoort J, Ha HR, Meier PJ, Fattinger K: Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology. 2002 Jul;36(1):164-72. [PubMed:12085361 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Sterol 14-demethylase activity
Specific Function:
Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
Gene Name:
CYP51A1
Uniprot ID:
Q16850
Molecular Weight:
56805.26 Da
References
  1. Ekins S, Mankowski DC, Hoover DJ, Lawton MP, Treadway JL, Harwood HJ Jr: Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. Drug Metab Dispos. 2007 Mar;35(3):493-500. Epub 2006 Dec 28. [PubMed:17194716 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Toxic substance binding
Specific Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Gene Name:
ALB
Uniprot ID:
P02768
Molecular Weight:
69365.94 Da
References
  1. Baneres-Roquet F, Gualtieri M, Villain-Guillot P, Pugniere M, Leonetti JP: Use of a surface plasmon resonance method to investigate antibiotic and plasma protein interactions. Antimicrob Agents Chemother. 2009 Apr;53(4):1528-31. doi: 10.1128/AAC.00971-08. Epub 2009 Jan 21. [PubMed:19164148 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.
Gene Name:
SLCO2B1
Uniprot ID:
O94956
Molecular Weight:
76709.98 Da
References
  1. Karlgren M, Vildhede A, Norinder U, Wisniewski JR, Kimoto E, Lai Y, Haglund U, Artursson P: Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. J Med Chem. 2012 May 24;55(10):4740-63. doi: 10.1021/jm300212s. Epub 2012 May 15. [PubMed:22541068 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Dixit V, Hariparsad N, Li F, Desai P, Thummel KE, Unadkat JD: Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions. Drug Metab Dispos. 2007 Oct;35(10):1853-9. Epub 2007 Jul 16. [PubMed:17639026 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitorinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Dixit V, Hariparsad N, Li F, Desai P, Thummel KE, Unadkat JD: Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions. Drug Metab Dispos. 2007 Oct;35(10):1853-9. Epub 2007 Jul 16. [PubMed:17639026 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid binding
Specific Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naph...
Gene Name:
UGT1A1
Uniprot ID:
P22309
Molecular Weight:
59590.91 Da
References
  1. Ellis E, Wagner M, Lammert F, Nemeth A, Gumhold J, Strassburg CP, Kylander C, Katsika D, Trauner M, Einarsson C, Marschall HU: Successful treatment of severe unconjugated hyperbilirubinemia via induction of UGT1A1 by rifampicin. J Hepatol. 2006 Jan;44(1):243-5. Epub 2005 Oct 27. [PubMed:16288819 ]
  2. Jemnitz K, Lengyel G, Vereczkey L: In vitro induction of bilirubin conjugation in primary rat hepatocyte culture. Biochem Biophys Res Commun. 2002 Feb 15;291(1):29-33. [PubMed:11829457 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Dixit V, Hariparsad N, Li F, Desai P, Thummel KE, Unadkat JD: Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions. Drug Metab Dispos. 2007 Oct;35(10):1853-9. Epub 2007 Jul 16. [PubMed:17639026 ]
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Dixit V, Hariparsad N, Li F, Desai P, Thummel KE, Unadkat JD: Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions. Drug Metab Dispos. 2007 Oct;35(10):1853-9. Epub 2007 Jul 16. [PubMed:17639026 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitorinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.
Gene Name:
CYP2A6
Uniprot ID:
P11509
Molecular Weight:
56501.005 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular Weight:
56848.42 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Monooxygenase activity
Specific Function:
Exhibits low testosterone 6-beta-hydroxylase activity.
Gene Name:
CYP3A43
Uniprot ID:
Q9HB55
Molecular Weight:
57669.21 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Leukotriene-b4 20-monooxygenase activity
Specific Function:
Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE).
Gene Name:
CYP4A11
Uniprot ID:
Q02928
Molecular Weight:
59347.31 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitorinducer
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Geick A, Eichelbaum M, Burk O: Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem. 2001 May 4;276(18):14581-7. Epub 2001 Jan 31. [PubMed:11297522 ]
  2. Schuetz EG, Beck WT, Schuetz JD: Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Mol Pharmacol. 1996 Feb;49(2):311-8. [PubMed:8632764 ]
  3. Greiner B, Eichelbaum M, Fritz P, Kreichgauer HP, von Richter O, Zundler J, Kroemer HK: The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin. J Clin Invest. 1999 Jul;104(2):147-53. [PubMed:10411543 ]
  4. Fardel O, Lecureur V, Loyer P, Guillouzo A: Rifampicin enhances anti-cancer drug accumulation and activity in multidrug-resistant cells. Biochem Pharmacol. 1995 May 11;49(9):1255-60. [PubMed:7763306 ]
  5. Collett A, Tanianis-Hughes J, Hallifax D, Warhurst G: Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo. Pharm Res. 2004 May;21(5):819-26. [PubMed:15180340 ]
  6. Kuypers DR, Verleden G, Naesens M, Vanrenterghem Y: Drug interaction between mycophenolate mofetil and rifampin: possible induction of uridine diphosphate-glucuronosyltransferase. Clin Pharmacol Ther. 2005 Jul;78(1):81-8. [PubMed:16003296 ]
  7. Gurley BJ, Barone GW, Williams DK, Carrier J, Breen P, Yates CR, Song PF, Hubbard MA, Tong Y, Cheboyina S: Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humans. Drug Metab Dispos. 2006 Jan;34(1):69-74. Epub 2005 Oct 12. [PubMed:16221754 ]
  8. Chen J, Raymond K: Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor. Ann Clin Microbiol Antimicrob. 2006 Feb 15;5:3. [PubMed:16480505 ]
  9. Lamba J, Strom S, Venkataramanan R, Thummel KE, Lin YS, Liu W, Cheng C, Lamba V, Watkins PB, Schuetz E: MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype. Clin Pharmacol Ther. 2006 Apr;79(4):325-38. Epub 2006 Feb 20. [PubMed:16580901 ]
  10. Huang R, Murry DJ, Kolwankar D, Hall SD, Foster DR: Vincristine transcriptional regulation of efflux drug transporters in carcinoma cell lines. Biochem Pharmacol. 2006 Jun 14;71(12):1695-704. Epub 2006 Apr 18. [PubMed:16620787 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B3
Uniprot ID:
Q9NPD5
Molecular Weight:
77402.175 Da
References
  1. Cui Y, Konig J, Leier I, Buchholz U, Keppler D: Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. J Biol Chem. 2001 Mar 30;276(13):9626-30. Epub 2000 Dec 27. [PubMed:11134001 ]
  2. Vavricka SR, Van Montfoort J, Ha HR, Meier PJ, Fattinger K: Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology. 2002 Jul;36(1):164-72. [PubMed:12085361 ]
  3. Cui Y, Konig J, Keppler D: Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2. Mol Pharmacol. 2001 Nov;60(5):934-43. [PubMed:11641421 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Transporter activity
Specific Function:
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
Gene Name:
ABCC1
Uniprot ID:
P33527
Molecular Weight:
171589.5 Da
References
  1. Courtois A, Payen L, Vernhet L, de Vries EG, Guillouzo A, Fardel O: Inhibition of multidrug resistance-associated protein (MRP) activity by rifampicin in human multidrug-resistant lung tumor cells. Cancer Lett. 1999 May 3;139(1):97-104. [PubMed:10408915 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.
Gene Name:
SLCO2B1
Uniprot ID:
O94956
Molecular Weight:
76709.98 Da
References
  1. Vavricka SR, Van Montfoort J, Ha HR, Meier PJ, Fattinger K: Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology. 2002 Jul;36(1):164-72. [PubMed:12085361 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Transporter activity
Specific Function:
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
Gene Name:
ABCB11
Uniprot ID:
O95342
Molecular Weight:
146405.83 Da
References
  1. Byrne JA, Strautnieks SS, Mieli-Vergani G, Higgins CF, Linton KJ, Thompson RJ: The human bile salt export pump: characterization of substrate specificity and identification of inhibitors. Gastroenterology. 2002 Nov;123(5):1649-58. [PubMed:12404239 ]
  2. Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. [PubMed:12739759 ]
  3. Noe J, Hagenbuch B, Meier PJ, St-Pierre MV: Characterization of the mouse bile salt export pump overexpressed in the baculovirus system. Hepatology. 2001 May;33(5):1223-31. [PubMed:11343252 ]
  4. Stieger B, Fattinger K, Madon J, Kullak-Ublick GA, Meier PJ: Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver. Gastroenterology. 2000 Feb;118(2):422-30. [PubMed:10648470 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. Vavricka SR, Van Montfoort J, Ha HR, Meier PJ, Fattinger K: Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology. 2002 Jul;36(1):164-72. [PubMed:12085361 ]
  2. Fattinger K, Cattori V, Hagenbuch B, Meier PJ, Stieger B: Rifamycin SV and rifampicin exhibit differential inhibition of the hepatic rat organic anion transporting polypeptides, Oatp1 and Oatp2. Hepatology. 2000 Jul;32(1):82-6. [PubMed:10869292 ]
  3. Shitara Y, Sugiyama D, Kusuhara H, Kato Y, Abe T, Meier PJ, Itoh T, Sugiyama Y: Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport. Pharm Res. 2002 Feb;19(2):147-53. [PubMed:11883641 ]
  4. van Montfoort JE, Stieger B, Meijer DK, Weinmann HJ, Meier PJ, Fattinger KE: Hepatic uptake of the magnetic resonance imaging contrast agent gadoxetate by the organic anion transporting polypeptide Oatp1. J Pharmacol Exp Ther. 1999 Jul;290(1):153-7. [PubMed:10381771 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate.
Gene Name:
SLC22A7
Uniprot ID:
Q9Y694
Molecular Weight:
60025.025 Da
References
  1. Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H: Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett. 1998 Jun 12;429(2):179-82. [PubMed:9650585 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B1
Uniprot ID:
Q9Y6L6
Molecular Weight:
76447.99 Da
References
  1. Cui Y, Konig J, Leier I, Buchholz U, Keppler D: Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. J Biol Chem. 2001 Mar 30;276(13):9626-30. Epub 2000 Dec 27. [PubMed:11134001 ]
  2. Vavricka SR, Van Montfoort J, Ha HR, Meier PJ, Fattinger K: Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology. 2002 Jul;36(1):164-72. [PubMed:12085361 ]
  3. Tirona RG, Leake BF, Wolkoff AW, Kim RB: Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation. J Pharmacol Exp Ther. 2003 Jan;304(1):223-8. [PubMed:12490595 ]
  4. Sharma P, Holmes VE, Elsby R, Lambert C, Surry D: Validation of cell-based OATP1B1 assays to assess drug transport and the potential for drug-drug interaction to support regulatory submissions. Xenobiotica. 2010 Jan;40(1):24-37. doi: 10.3109/00498250903351013. [PubMed:19919292 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Organic anion transmembrane transporter activity
Specific Function:
Acts as a multispecific organic anion pump which can transport nucleotide analogs.
Gene Name:
ABCC5
Uniprot ID:
O15440
Molecular Weight:
160658.8 Da
References
  1. Schrenk D, Baus PR, Ermel N, Klein C, Vorderstemann B, Kauffmann HM: Up-regulation of transporters of the MRP family by drugs and toxins. Toxicol Lett. 2001 Mar 31;120(1-3):51-7. [PubMed:11323161 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Organic anion transmembrane transporter activity
Specific Function:
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Gene Name:
ABCC2
Uniprot ID:
Q92887
Molecular Weight:
174205.64 Da
References
  1. Kauffmann HM, Pfannschmidt S, Zoller H, Benz A, Vorderstemann B, Webster JI, Schrenk D: Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression. Toxicology. 2002 Feb 28;171(2-3):137-46. [PubMed:11836020 ]
  2. Fromm MF, Kauffmann HM, Fritz P, Burk O, Kroemer HK, Warzok RW, Eichelbaum M, Siegmund W, Schrenk D: The effect of rifampin treatment on intestinal expression of human MRP transporters. Am J Pathol. 2000 Nov;157(5):1575-80. [PubMed:11073816 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Organic anion transmembrane transporter activity
Specific Function:
May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity).
Gene Name:
ABCC3
Uniprot ID:
O15438
Molecular Weight:
169341.14 Da
References
  1. Teng S, Jekerle V, Piquette-Miller M: Induction of ABCC3 (MRP3) by pregnane X receptor activators. Drug Metab Dispos. 2003 Nov;31(11):1296-9. [PubMed:14570758 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23