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Identification
NameRifabutin
Accession NumberDB00615  (APRD00094)
TypeSmall Molecule
GroupsApproved
DescriptionA broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. [PubChem]
Structure
Thumb
Synonyms
1,4-Dihydro-1-deoxy-1',4-didehydro-5'-(2-methylpropyl)-1-oxorifamycin xiv
4-Deoxo-3,4-(2-spiro(N-isobutyl-4-piperidyl)-2,5-dihydro-1H-imidazo)-rifamycin S
4-N-Isobutylspiropiperidylrifamycin S
Ansamicin
Ansamycin
Mycobutin (tn)
Rifabutin
Rifabutina
Rifabutine
Rifabutinum
External Identifiers
  • LM 427
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Mycobutincapsule150 mg/1oralPharmacia and Upjohn Company1992-12-23Not applicableUs
Mycobutincapsule150 mg/1oralDepartment Of State Health Services, Pharmacy Branch1992-12-23Not applicableUs
Mycobutincapsule150 mg/1oralPhysicians Total Care, Inc.1995-03-15Not applicableUs
Mycobutincapsule150 mgoralPfizer Canada Inc1995-12-31Not applicableCanada
Rifabutincapsule150 mg/1oralGreenstone LLC2014-04-07Not applicableUs
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Rifabutincapsule150 mg/1oralLupin Pharmaceuticals, Inc.2014-03-26Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AnsatipinPfizer
AnsatipineSERB
RibutinLupin
Brand mixturesNot Available
SaltsNot Available
Categories
UNII1W306TDA6S
CAS number72559-06-9
WeightAverage: 847.0047
Monoisotopic: 846.441508846
Chemical FormulaC46H62N4O11
InChI KeyInChIKey=ATEBXHFBFRCZMA-VXTBVIBXSA-N
InChI
InChI=1S/C46H62N4O11/c1-22(2)21-50-18-16-46(17-19-50)48-34-31-32-39(54)28(8)42-33(31)43(56)45(10,61-42)59-20-15-30(58-11)25(5)41(60-29(9)51)27(7)38(53)26(6)37(52)23(3)13-12-14-24(4)44(57)47-36(40(32)55)35(34)49-46/h12-15,20,22-23,25-27,30,37-38,41,49,52-54H,16-19,21H2,1-11H3,(H,47,57)/b13-12+,20-15+,24-14-/t23-,25+,26+,27+,30-,37-,38+,41+,45-/m0/s1
IUPAC Name
(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17-trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-1'-(2-methylpropyl)-6,23,32-trioxo-8,33-dioxa-24,27,29-triazaspiro[pentacyclo[23.6.1.1⁴,⁷.0⁵,³¹.0²⁶,³⁰]tritriacontane-28,4'-piperidin]-1(31),2,4,9,19,21,25,29-octaen-13-yl acetate
SMILES
CO[[email protected]]1\C=C\O[C@@]2(C)OC3=C(C2=O)C2=C(C(O)=C3C)C(=O)C(NC(=O)\C(C)=C/C=C/[[email protected]](C)[[email protected]](O)[C@@H](C)[C@@H](O)[C@@H](C)[[email protected]](OC(C)=O)[C@@H]1C)=C1NC3(CCN(CC3)CC(C)C)N=C21
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as macrolactams. These are cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. They are nitrogen analogues (the a nitrogen atom replacing the o atom of the cyclic carboxylic acid group ) of the naturally occurring macrolides.
KingdomOrganic compounds
Super ClassPhenylpropanoids and polyketides
ClassMacrolactams
Sub ClassNot Available
Direct ParentMacrolactams
Alternative Parents
Substituents
  • Naphthofuran
  • Macrolactam
  • Naphthalene
  • Azaspirodecane
  • Benzofuran
  • Aryl alkyl ketone
  • Aryl ketone
  • Benzenoid
  • Piperidine
  • Acetate salt
  • Vinylogous amide
  • Vinylogous acid
  • 3-imidazoline
  • Tertiary aliphatic amine
  • Tertiary amine
  • Secondary carboxylic acid amide
  • Secondary alcohol
  • Polyol
  • Lactam
  • Ketone
  • Ketimine
  • Carboxylic acid ester
  • Carboxamide group
  • Oxacycle
  • Azacycle
  • Organoheterocyclic compound
  • Organic 1,3-dipolar compound
  • Propargyl-type 1,3-dipolar organic compound
  • Ether
  • Dialkyl ether
  • Carboxylic acid derivative
  • Carboxylic acid amide
  • Acetal
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Imine
  • Carbonyl group
  • Amine
  • Alcohol
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor the prevention of disseminated Mycobacterium avium complex (MAC) disease in patients with advanced HIV infection.
PharmacodynamicsRifabutin is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. It is bactericidal and has a very broad spectrum of activity against most gram-positive and gram-negative organisms (including Pseudomonas aeruginosa) and specifically Mycobacterium tuberculosis. Because of rapid emergence of resistant bacteria, use is restricted to treatment of mycobacterial infections and a few other indications. Rifabutin is well absorbed when taken orally and is distributed widely in body tissues and fluids, including the CSF. It is metabolized in the liver and eliminated in bile and, to a much lesser extent, in urine, but dose adjustments are unnecessary with renal insufficiency.
Mechanism of actionRifabutin acts via the inhibition of DNA-dependent RNA polymerase in gram-positive and some gram-negative bacteria, leading to a suppression of RNA synthesis and cell death.
Related Articles
AbsorptionRifabutin is readily absorbed from the gastrointestinal tract, with an absolute bioavailability averaging 20%.
Volume of distributionNot Available
Protein binding85%
Metabolism

Hepatic. Of the five metabolites that have been identified, 25-O-desacetyl and 31-hydroxy are the most predominant. The former metabolite has an activity equal to the parent drug and contributes up to 10% to the total antimicrobial activity.

SubstrateEnzymesProduct
Rifabutin
27-O-demethylrifabutinDetails
Rifabutin
Not Available
25-O-desacetyl rifabutinDetails
Rifabutin
Not Available
31-hydroxy rifabutinDetails
Route of eliminationA mass-balance study in three healthy adult volunteers with 14C-labeled rifabutin showed that 53% of the oral dose was excreted in the urine, primarily as metabolites. About 30% of the dose is excreted in the feces.
Half life45 (± 17) hours
Clearance
  • 0.69 +/- 0.32 L/hr/kg
ToxicityLD50 = 4.8 g/kg (mouse, male)
Affected organisms
  • Enteric bacteria and other eubacteria
  • Mycobacterium tuberculosis
  • Mycobacterium leprae
  • Mycobacterium avium
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.5507
Blood Brain Barrier-0.9921
Caco-2 permeable-0.7072
P-glycoprotein substrateSubstrate0.9612
P-glycoprotein inhibitor IInhibitor0.5415
P-glycoprotein inhibitor IIInhibitor0.6516
Renal organic cation transporterNon-inhibitor0.8178
CYP450 2C9 substrateNon-substrate0.819
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.745
CYP450 1A2 substrateNon-inhibitor0.9046
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorNon-inhibitor0.8308
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8909
Ames testNon AMES toxic0.6724
CarcinogenicityNon-carcinogens0.9195
BiodegradationNot ready biodegradable0.9687
Rat acute toxicity2.5143 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.946
hERG inhibition (predictor II)Inhibitor0.5416
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Pharmacia and upjohn co
Packagers
Dosage forms
FormRouteStrength
Capsuleoral150 mg/1
Capsuleoral150 mg
Prices
Unit descriptionCostUnit
Mycobutin 150 mg capsule13.01USD capsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
water solubilityMinimally soluble (0.19 mg/mL)Not Available
logP4.1Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.017 mg/mLALOGPS
logP4.25ALOGPS
logP4.19ChemAxon
logS-4.7ALOGPS
pKa (Strongest Acidic)7.93ChemAxon
pKa (Strongest Basic)8.62ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count13ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area205.55 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity232.64 m3·mol-1ChemAxon
Polarizability90.72 Å3ChemAxon
Number of Rings6ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesJ04AB04
AHFS Codes
  • 08:16.04
PDB EntriesNot Available
FDA labelDownload (69.5 KB)
MSDSDownload (58.4 KB)
Interactions
Drug Interactions
Drug
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be decreased when it is combined with Rifabutin.
AbirateroneThe serum concentration of Rifabutin can be increased when it is combined with Abiraterone.
AbirateroneThe serum concentration of Abiraterone can be decreased when it is combined with Rifabutin.
AcenocoumarolThe metabolism of Acenocoumarol can be increased when combined with Rifabutin.
AcetaminophenThe metabolism of Acetaminophen can be increased when combined with Rifabutin.
AdinazolamThe metabolism of Adinazolam can be increased when combined with Rifabutin.
AlbendazoleThe metabolism of Albendazole can be increased when combined with Rifabutin.
AlclometasoneThe serum concentration of Alclometasone can be decreased when it is combined with Rifabutin.
AldosteroneThe serum concentration of Aldosterone can be decreased when it is combined with Rifabutin.
AlfentanilThe metabolism of Alfentanil can be increased when combined with Rifabutin.
AlfuzosinThe metabolism of Alfuzosin can be increased when combined with Rifabutin.
AliskirenThe metabolism of Aliskiren can be increased when combined with Rifabutin.
AllylestrenolThe metabolism of Allylestrenol can be increased when combined with Rifabutin.
AlmotriptanThe metabolism of Almotriptan can be increased when combined with Rifabutin.
AlogliptinThe metabolism of Alogliptin can be increased when combined with Rifabutin.
AlosetronThe metabolism of Alosetron can be increased when combined with Rifabutin.
AlprazolamThe metabolism of Alprazolam can be increased when combined with Rifabutin.
AmbrisentanThe metabolism of Ambrisentan can be increased when combined with Rifabutin.
AmbroxolThe metabolism of Ambroxol can be increased when combined with Rifabutin.
AmcinonideThe serum concentration of Amcinonide can be decreased when it is combined with Rifabutin.
AminophenazoneThe metabolism of Aminophenazone can be increased when combined with Rifabutin.
AminophyllineThe metabolism of Aminophylline can be increased when combined with Rifabutin.
AmiodaroneThe metabolism of Amiodarone can be increased when combined with Rifabutin.
AmitriptylineThe metabolism of Amitriptyline can be increased when combined with Rifabutin.
AmlodipineThe metabolism of Amlodipine can be increased when combined with Rifabutin.
AmprenavirThe metabolism of Amprenavir can be increased when combined with Rifabutin.
AntipyrineThe metabolism of Antipyrine can be increased when combined with Rifabutin.
ApixabanThe serum concentration of Apixaban can be decreased when it is combined with Rifabutin.
ApremilastThe serum concentration of Apremilast can be decreased when it is combined with Rifabutin.
AprepitantThe serum concentration of Rifabutin can be increased when it is combined with Aprepitant.
AprepitantThe metabolism of Aprepitant can be increased when combined with Rifabutin.
ArgatrobanThe metabolism of Argatroban can be increased when combined with Rifabutin.
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Rifabutin.
ArtemetherThe serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with Rifabutin resulting in a loss in efficacy.
AsenapineThe metabolism of Asenapine can be increased when combined with Rifabutin.
AstemizoleThe metabolism of Astemizole can be increased when combined with Rifabutin.
AtazanavirThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Atazanavir.
AtazanavirThe metabolism of Atazanavir can be increased when combined with Rifabutin.
AtomoxetineThe metabolism of Rifabutin can be decreased when combined with Atomoxetine.
AtorvastatinThe metabolism of Atorvastatin can be increased when combined with Rifabutin.
AvanafilThe metabolism of Avanafil can be increased when combined with Rifabutin.
AxitinibThe serum concentration of Axitinib can be decreased when it is combined with Rifabutin.
AzelastineThe metabolism of Azelastine can be increased when combined with Rifabutin.
AzithromycinThe metabolism of Azithromycin can be increased when combined with Rifabutin.
BanoxantroneThe metabolism of Banoxantrone can be increased when combined with Rifabutin.
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be decreased when it is combined with Rifabutin.
BedaquilineThe serum concentration of Bedaquiline can be decreased when it is combined with Rifabutin.
BenzphetamineThe metabolism of Benzphetamine can be increased when combined with Rifabutin.
Benzyl alcoholThe metabolism of Benzyl alcohol can be increased when combined with Rifabutin.
BetamethasoneThe serum concentration of Betamethasone can be decreased when it is combined with Rifabutin.
BexaroteneThe serum concentration of Rifabutin can be decreased when it is combined with Bexarotene.
BexaroteneThe metabolism of Bexarotene can be increased when combined with Rifabutin.
BezafibrateThe metabolism of Bezafibrate can be increased when combined with Rifabutin.
BicalutamideThe metabolism of Bicalutamide can be increased when combined with Rifabutin.
BisoprololThe metabolism of Bisoprolol can be increased when combined with Rifabutin.
BoceprevirThe serum concentration of Boceprevir can be decreased when it is combined with Rifabutin.
BoceprevirThe metabolism of Rifabutin can be decreased when combined with Boceprevir.
BortezomibThe serum concentration of Bortezomib can be decreased when it is combined with Rifabutin.
BortezomibThe metabolism of Rifabutin can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Rifabutin can be decreased when it is combined with Bosentan.
BosentanThe metabolism of Bosentan can be increased when combined with Rifabutin.
BosutinibThe serum concentration of Bosutinib can be decreased when it is combined with Rifabutin.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be decreased when it is combined with Rifabutin.
BrexpiprazoleThe serum concentration of Brexpiprazole can be decreased when it is combined with Rifabutin.
BrinzolamideThe metabolism of Brinzolamide can be increased when combined with Rifabutin.
BromazepamThe metabolism of Bromazepam can be increased when combined with Rifabutin.
BromocriptineThe metabolism of Bromocriptine can be increased when combined with Rifabutin.
BrompheniramineThe metabolism of Brompheniramine can be increased when combined with Rifabutin.
BudesonideThe serum concentration of Budesonide can be decreased when it is combined with Rifabutin.
BupivacaineThe metabolism of Bupivacaine can be increased when combined with Rifabutin.
BuprenorphineThe metabolism of Buprenorphine can be increased when combined with Rifabutin.
BupropionThe metabolism of Bupropion can be increased when combined with Rifabutin.
BuspironeThe metabolism of Buspirone can be increased when combined with Rifabutin.
BusulfanThe metabolism of Busulfan can be increased when combined with Rifabutin.
CabazitaxelThe metabolism of Cabazitaxel can be increased when combined with Rifabutin.
CabergolineThe metabolism of Cabergoline can be increased when combined with Rifabutin.
CabozantinibThe serum concentration of Cabozantinib can be decreased when it is combined with Rifabutin.
CaffeineThe metabolism of Caffeine can be increased when combined with Rifabutin.
CalcitriolThe metabolism of Calcitriol can be increased when combined with Rifabutin.
CanagliflozinThe metabolism of Canagliflozin can be increased when combined with Rifabutin.
CannabidiolThe serum concentration of Cannabidiol can be decreased when it is combined with Rifabutin.
CarbamazepineThe metabolism of Rifabutin can be increased when combined with Carbamazepine.
CarbinoxamineThe metabolism of Carbinoxamine can be increased when combined with Rifabutin.
CariprazineThe metabolism of Cariprazine can be increased when combined with Rifabutin.
CarvedilolThe metabolism of Carvedilol can be increased when combined with Rifabutin.
CelecoxibThe metabolism of Celecoxib can be increased when combined with Rifabutin.
CeliprololThe metabolism of Celiprolol can be increased when combined with Rifabutin.
CephalexinThe metabolism of Cephalexin can be increased when combined with Rifabutin.
CeritinibThe serum concentration of Rifabutin can be increased when it is combined with Ceritinib.
CeritinibThe serum concentration of Ceritinib can be decreased when it is combined with Rifabutin.
CerivastatinThe metabolism of Cerivastatin can be increased when combined with Rifabutin.
CevimelineThe metabolism of Cevimeline can be increased when combined with Rifabutin.
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be increased when combined with Rifabutin.
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be increased when combined with Rifabutin.
ChloroquineThe metabolism of Chloroquine can be increased when combined with Rifabutin.
ChlorphenamineThe metabolism of Chlorphenamine can be increased when combined with Rifabutin.
ChlorpromazineThe metabolism of Chlorpromazine can be increased when combined with Rifabutin.
ChlorzoxazoneThe metabolism of Chlorzoxazone can be increased when combined with Rifabutin.
CholecalciferolThe metabolism of Cholecalciferol can be increased when combined with Rifabutin.
CiclesonideThe serum concentration of Ciclesonide can be decreased when it is combined with Rifabutin.
CilostazolThe metabolism of Cilostazol can be increased when combined with Rifabutin.
CinacalcetThe metabolism of Cinacalcet can be increased when combined with Rifabutin.
CisaprideThe metabolism of Cisapride can be increased when combined with Rifabutin.
CitalopramThe metabolism of Citalopram can be increased when combined with Rifabutin.
ClarithromycinThe serum concentration of the active metabolites of Clarithromycin can be increased when Clarithromycin is used in combination with Rifabutin.
ClarithromycinThe metabolism of Rifabutin can be decreased when combined with Clarithromycin.
ClemastineThe metabolism of Rifabutin can be decreased when combined with Clemastine.
ClindamycinThe metabolism of Clindamycin can be increased when combined with Rifabutin.
ClobazamThe metabolism of Clobazam can be increased when combined with Rifabutin.
Clobetasol propionateThe serum concentration of Clobetasol propionate can be decreased when it is combined with Rifabutin.
ClocortoloneThe serum concentration of Clocortolone can be decreased when it is combined with Rifabutin.
ClofazimineThe metabolism of Clofazimine can be increased when combined with Rifabutin.
ClofibrateThe metabolism of Clofibrate can be increased when combined with Rifabutin.
clomethiazoleThe metabolism of clomethiazole can be increased when combined with Rifabutin.
ClomipramineThe metabolism of Clomipramine can be increased when combined with Rifabutin.
ClonazepamThe metabolism of Clonazepam can be increased when combined with Rifabutin.
ClonidineThe metabolism of Clonidine can be increased when combined with Rifabutin.
ClopidogrelThe metabolism of Clopidogrel can be increased when combined with Rifabutin.
ClorazepateThe metabolism of Clorazepate can be increased when combined with Rifabutin.
ClotiazepamThe metabolism of Clotiazepam can be increased when combined with Rifabutin.
ClotrimazoleThe metabolism of Rifabutin can be decreased when combined with Clotrimazole.
ClozapineThe serum concentration of Clozapine can be decreased when it is combined with Rifabutin.
CobicistatThe metabolism of Rifabutin can be decreased when combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be decreased when it is combined with Rifabutin.
CocaineThe metabolism of Cocaine can be increased when combined with Rifabutin.
CodeineThe metabolism of Codeine can be increased when combined with Rifabutin.
ColchicineThe metabolism of Colchicine can be increased when combined with Rifabutin.
ConivaptanThe serum concentration of Rifabutin can be increased when it is combined with Conivaptan.
ConivaptanThe metabolism of Conivaptan can be increased when combined with Rifabutin.
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be increased when combined with Rifabutin.
Cortisone acetateThe serum concentration of Cortisone acetate can be decreased when it is combined with Rifabutin.
CrizotinibThe serum concentration of Crizotinib can be decreased when it is combined with Rifabutin.
CrizotinibThe metabolism of Rifabutin can be decreased when combined with Crizotinib.
CyclobenzaprineThe metabolism of Cyclobenzaprine can be increased when combined with Rifabutin.
CyclophosphamideThe metabolism of Cyclophosphamide can be increased when combined with Rifabutin.
CyclosporineThe metabolism of Cyclosporine can be increased when combined with Rifabutin.
Cyproterone acetateThe serum concentration of Rifabutin can be decreased when it is combined with Cyproterone acetate.
CytarabineThe metabolism of Cytarabine can be increased when combined with Rifabutin.
DabrafenibThe serum concentration of Rifabutin can be decreased when it is combined with Dabrafenib.
DabrafenibThe metabolism of Dabrafenib can be increased when combined with Rifabutin.
DaclatasvirThe serum concentration of Daclatasvir can be decreased when it is combined with Rifabutin.
DantroleneThe metabolism of Dantrolene can be increased when combined with Rifabutin.
DapagliflozinThe metabolism of Dapagliflozin can be increased when combined with Rifabutin.
DapsoneThe metabolism of Dapsone can be increased when combined with Rifabutin.
DarifenacinThe metabolism of Darifenacin can be increased when combined with Rifabutin.
DarunavirThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Darunavir.
DarunavirThe metabolism of Darunavir can be increased when combined with Rifabutin.
DasabuvirThe metabolism of Dasabuvir can be increased when combined with Rifabutin.
DasatinibThe serum concentration of Rifabutin can be increased when it is combined with Dasatinib.
DasatinibThe serum concentration of Dasatinib can be decreased when it is combined with Rifabutin.
DaunorubicinThe metabolism of Daunorubicin can be increased when combined with Rifabutin.
DeferasiroxThe serum concentration of Rifabutin can be decreased when it is combined with Deferasirox.
DehydroepiandrosteroneThe serum concentration of Dehydroepiandrosterone can be decreased when it is combined with Rifabutin.
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be decreased when it is combined with Rifabutin.
DelavirdineThe metabolism of Delavirdine can be increased when combined with Rifabutin.
DesoximetasoneThe serum concentration of Desoximetasone can be decreased when it is combined with Rifabutin.
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be decreased when it is combined with Rifabutin.
DesvenlafaxineThe metabolism of Desvenlafaxine can be increased when combined with Rifabutin.
DexamethasoneThe serum concentration of Rifabutin can be decreased when it is combined with Dexamethasone.
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be decreased when it is combined with Rifabutin.
DextromethorphanThe metabolism of Dextromethorphan can be increased when combined with Rifabutin.
DextropropoxypheneThe metabolism of Dextropropoxyphene can be increased when combined with Rifabutin.
DiazepamThe metabolism of Diazepam can be increased when combined with Rifabutin.
DiclofenacThe metabolism of Diclofenac can be increased when combined with Rifabutin.
DienogestThe serum concentration of Dienogest can be decreased when it is combined with Rifabutin.
DiflorasoneThe serum concentration of Diflorasone can be decreased when it is combined with Rifabutin.
DifluocortoloneThe serum concentration of Difluocortolone can be decreased when it is combined with Rifabutin.
DifluprednateThe serum concentration of Difluprednate can be decreased when it is combined with Rifabutin.
DigitoxinThe metabolism of Digitoxin can be increased when combined with Rifabutin.
DigoxinThe metabolism of Digoxin can be increased when combined with Rifabutin.
DihydrocodeineThe metabolism of Dihydrocodeine can be increased when combined with Rifabutin.
DihydroergotamineThe metabolism of Dihydroergotamine can be increased when combined with Rifabutin.
DiltiazemThe metabolism of Diltiazem can be increased when combined with Rifabutin.
DisopyramideThe metabolism of Disopyramide can be increased when combined with Rifabutin.
DisulfiramThe metabolism of Disulfiram can be increased when combined with Rifabutin.
DocetaxelThe metabolism of Docetaxel can be increased when combined with Rifabutin.
DofetilideThe metabolism of Dofetilide can be increased when combined with Rifabutin.
DolasetronThe metabolism of Dolasetron can be increased when combined with Rifabutin.
DomperidoneThe metabolism of Domperidone can be increased when combined with Rifabutin.
DonepezilThe metabolism of Donepezil can be increased when combined with Rifabutin.
DorzolamideThe metabolism of Dorzolamide can be increased when combined with Rifabutin.
DoxepinThe metabolism of Doxepin can be increased when combined with Rifabutin.
DoxorubicinThe serum concentration of Doxorubicin can be decreased when it is combined with Rifabutin.
DoxycyclineThe metabolism of Rifabutin can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Dronabinol can be decreased when it is combined with Rifabutin.
DronedaroneThe serum concentration of Dronedarone can be decreased when it is combined with Rifabutin.
DronedaroneThe metabolism of Rifabutin can be decreased when combined with Dronedarone.
DutasterideThe metabolism of Dutasteride can be increased when combined with Rifabutin.
EfavirenzThe serum concentration of Rifabutin can be decreased when it is combined with Efavirenz.
EfavirenzThe metabolism of Efavirenz can be increased when combined with Rifabutin.
EletriptanThe metabolism of Eletriptan can be increased when combined with Rifabutin.
EliglustatThe serum concentration of Eliglustat can be decreased when it is combined with Rifabutin.
ElvitegravirThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Elvitegravir.
ElvitegravirThe metabolism of Elvitegravir can be increased when combined with Rifabutin.
EnalaprilThe metabolism of Enalapril can be increased when combined with Rifabutin.
EnzalutamideThe serum concentration of Enzalutamide can be decreased when it is combined with Rifabutin.
EpinastineThe metabolism of Epinastine can be increased when combined with Rifabutin.
EplerenoneThe metabolism of Eplerenone can be increased when combined with Rifabutin.
EquileninThe serum concentration of Equilenin can be decreased when it is combined with Rifabutin.
EquilinThe serum concentration of Equilin can be decreased when it is combined with Rifabutin.
ErgocalciferolThe metabolism of Ergocalciferol can be increased when combined with Rifabutin.
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be increased when combined with Rifabutin.
ErgonovineThe metabolism of Ergonovine can be increased when combined with Rifabutin.
ErgotamineThe metabolism of Ergotamine can be increased when combined with Rifabutin.
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Rifabutin.
ErythromycinThe metabolism of Erythromycin can be increased when combined with Rifabutin.
EscitalopramThe metabolism of Escitalopram can be increased when combined with Rifabutin.
Eslicarbazepine acetateThe serum concentration of Rifabutin can be decreased when it is combined with Eslicarbazepine acetate.
EsomeprazoleThe metabolism of Esomeprazole can be increased when combined with Rifabutin.
EstazolamThe metabolism of Estazolam can be increased when combined with Rifabutin.
EstradiolThe metabolism of Estradiol can be increased when combined with Rifabutin.
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be increased when combined with Rifabutin.
EstramustineThe metabolism of Estramustine can be increased when combined with Rifabutin.
EstroneThe serum concentration of Estrone can be decreased when it is combined with Rifabutin.
Estrone sulfateThe metabolism of Estrone sulfate can be increased when combined with Rifabutin.
EszopicloneThe metabolism of Eszopiclone can be increased when combined with Rifabutin.
EthanolThe metabolism of Ethanol can be increased when combined with Rifabutin.
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be increased when combined with Rifabutin.
EthosuximideThe metabolism of Ethosuximide can be increased when combined with Rifabutin.
EthylmorphineThe metabolism of Ethylmorphine can be increased when combined with Rifabutin.
EtonogestrelThe metabolism of Etonogestrel can be increased when combined with Rifabutin.
EtoposideThe serum concentration of Etoposide can be decreased when it is combined with Rifabutin.
EtoricoxibThe metabolism of Etoricoxib can be increased when combined with Rifabutin.
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Rifabutin.
EverolimusThe serum concentration of Everolimus can be decreased when it is combined with Rifabutin.
ExemestaneThe serum concentration of Exemestane can be decreased when it is combined with Rifabutin.
FamciclovirThe metabolism of Famciclovir can be increased when combined with Rifabutin.
FelbamateThe metabolism of Felbamate can be increased when combined with Rifabutin.
FelodipineThe metabolism of Felodipine can be increased when combined with Rifabutin.
FenofibrateThe metabolism of Fenofibrate can be increased when combined with Rifabutin.
FentanylThe serum concentration of Fentanyl can be decreased when it is combined with Rifabutin.
FesoterodineThe metabolism of Fesoterodine can be increased when combined with Rifabutin.
FinasterideThe metabolism of Finasteride can be increased when combined with Rifabutin.
FingolimodThe metabolism of Fingolimod can be increased when combined with Rifabutin.
FlibanserinThe serum concentration of Flibanserin can be decreased when it is combined with Rifabutin.
FluconazoleThe metabolism of Rifabutin can be decreased when combined with Fluconazole.
FludrocortisoneThe serum concentration of Fludrocortisone can be decreased when it is combined with Rifabutin.
FlumethasoneThe serum concentration of Flumethasone can be decreased when it is combined with Rifabutin.
FlunisolideThe serum concentration of Flunisolide can be decreased when it is combined with Rifabutin.
FlunitrazepamThe metabolism of Flunitrazepam can be increased when combined with Rifabutin.
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be decreased when it is combined with Rifabutin.
FluocinonideThe serum concentration of Fluocinonide can be decreased when it is combined with Rifabutin.
FluocortoloneThe serum concentration of Fluocortolone can be decreased when it is combined with Rifabutin.
FluorometholoneThe serum concentration of Fluorometholone can be decreased when it is combined with Rifabutin.
FluoxetineThe metabolism of Fluoxetine can be increased when combined with Rifabutin.
FluprednideneThe serum concentration of Fluprednidene can be decreased when it is combined with Rifabutin.
FluprednisoloneThe serum concentration of Fluprednisolone can be decreased when it is combined with Rifabutin.
FlurandrenolideThe serum concentration of Flurandrenolide can be decreased when it is combined with Rifabutin.
FlurazepamThe metabolism of Flurazepam can be increased when combined with Rifabutin.
FlutamideThe metabolism of Flutamide can be increased when combined with Rifabutin.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be decreased when it is combined with Rifabutin.
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be decreased when it is combined with Rifabutin.
FluvastatinThe metabolism of Fluvastatin can be increased when combined with Rifabutin.
FluvoxamineThe metabolism of Rifabutin can be decreased when combined with Fluvoxamine.
FosamprenavirThe metabolism of Fosamprenavir can be increased when combined with Rifabutin.
FosaprepitantThe serum concentration of Rifabutin can be increased when it is combined with Fosaprepitant.
FosphenytoinThe metabolism of Rifabutin can be increased when combined with Fosphenytoin.
FulvestrantThe metabolism of Fulvestrant can be increased when combined with Rifabutin.
Fusidic AcidThe serum concentration of Rifabutin can be increased when it is combined with Fusidic Acid.
GalantamineThe metabolism of Galantamine can be increased when combined with Rifabutin.
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Rifabutin.
GemfibrozilThe metabolism of Gemfibrozil can be increased when combined with Rifabutin.
GlipizideThe metabolism of Glipizide can be increased when combined with Rifabutin.
GlyburideThe metabolism of Glyburide can be increased when combined with Rifabutin.
GranisetronThe metabolism of Granisetron can be increased when combined with Rifabutin.
GrepafloxacinThe metabolism of Grepafloxacin can be increased when combined with Rifabutin.
GuanfacineThe serum concentration of Guanfacine can be decreased when it is combined with Rifabutin.
HalofantrineThe metabolism of Halofantrine can be increased when combined with Rifabutin.
HaloperidolThe metabolism of Haloperidol can be increased when combined with Rifabutin.
HalothaneThe metabolism of Halothane can be increased when combined with Rifabutin.
HexobarbitalThe metabolism of Hexobarbital can be increased when combined with Rifabutin.
Histamine PhosphateThe metabolism of Histamine Phosphate can be increased when combined with Rifabutin.
HydrocodoneThe serum concentration of Hydrocodone can be decreased when it is combined with Rifabutin.
HydrocortisoneThe serum concentration of Hydrocortisone can be decreased when it is combined with Rifabutin.
HydromorphoneThe metabolism of Hydromorphone can be increased when combined with Rifabutin.
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be increased when combined with Rifabutin.
IbrutinibThe serum concentration of Ibrutinib can be decreased when it is combined with Rifabutin.
IdelalisibThe serum concentration of Rifabutin can be increased when it is combined with Idelalisib.
IdelalisibThe serum concentration of Idelalisib can be decreased when it is combined with Rifabutin.
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be increased when Ifosfamide is used in combination with Rifabutin.
IloperidoneThe metabolism of Iloperidone can be increased when combined with Rifabutin.
ImatinibThe serum concentration of Imatinib can be decreased when it is combined with Rifabutin.
ImatinibThe metabolism of Rifabutin can be decreased when combined with Imatinib.
ImipramineThe metabolism of Imipramine can be increased when combined with Rifabutin.
ImiquimodThe metabolism of Imiquimod can be increased when combined with Rifabutin.
IndacaterolThe metabolism of Indacaterol can be increased when combined with Rifabutin.
IndapamideThe metabolism of Indapamide can be increased when combined with Rifabutin.
IndinavirThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Indinavir.
IndinavirThe metabolism of Indinavir can be increased when combined with Rifabutin.
Ipratropium bromideThe metabolism of Ipratropium bromide can be increased when combined with Rifabutin.
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be reduced when Irinotecan is used in combination with Rifabutin resulting in a loss in efficacy.
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Rifabutin resulting in a loss in efficacy.
IsavuconazoniumThe metabolism of Rifabutin can be decreased when combined with Isavuconazonium.
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be increased when combined with Rifabutin.
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be increased when combined with Rifabutin.
IsradipineThe metabolism of Isradipine can be increased when combined with Rifabutin.
ItraconazoleThe serum concentration of Itraconazole can be decreased when it is combined with Rifabutin.
ItraconazoleThe metabolism of Rifabutin can be decreased when combined with Itraconazole.
IvabradineThe serum concentration of Ivabradine can be decreased when it is combined with Rifabutin.
IvacaftorThe serum concentration of Rifabutin can be increased when it is combined with Ivacaftor.
IvacaftorThe serum concentration of Ivacaftor can be decreased when it is combined with Rifabutin.
IvermectinThe metabolism of Ivermectin can be increased when combined with Rifabutin.
IxabepiloneThe serum concentration of Ixabepilone can be decreased when it is combined with Rifabutin.
IxazomibThe serum concentration of Ixazomib can be decreased when it is combined with Rifabutin.
KetamineThe metabolism of Ketamine can be increased when combined with Rifabutin.
KetazolamThe metabolism of Ketazolam can be increased when combined with Rifabutin.
KetobemidoneThe metabolism of Ketobemidone can be increased when combined with Rifabutin.
KetoconazoleThe metabolism of Ketoconazole can be increased when combined with Rifabutin.
LansoprazoleThe metabolism of Lansoprazole can be increased when combined with Rifabutin.
LapatinibThe serum concentration of Lapatinib can be decreased when it is combined with Rifabutin.
LaquinimodThe metabolism of Laquinimod can be increased when combined with Rifabutin.
LedipasvirThe serum concentration of Ledipasvir can be decreased when it is combined with Rifabutin.
LenvatinibThe metabolism of Lenvatinib can be increased when combined with Rifabutin.
LercanidipineThe metabolism of Lercanidipine can be increased when combined with Rifabutin.
LetrozoleThe metabolism of Letrozole can be increased when combined with Rifabutin.
LevobupivacaineThe metabolism of Levobupivacaine can be increased when combined with Rifabutin.
LevocetirizineThe metabolism of Levocetirizine can be increased when combined with Rifabutin.
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be increased when combined with Rifabutin.
LevomilnacipranThe metabolism of Levomilnacipran can be increased when combined with Rifabutin.
LevonorgestrelThe metabolism of Levonorgestrel can be increased when combined with Rifabutin.
LevothyroxineThe metabolism of Levothyroxine can be increased when combined with Rifabutin.
LidocaineThe metabolism of Lidocaine can be increased when combined with Rifabutin.
LinagliptinThe serum concentration of Linagliptin can be decreased when it is combined with Rifabutin.
LisurideThe metabolism of Lisuride can be increased when combined with Rifabutin.
LomitapideThe metabolism of Lomitapide can be increased when combined with Rifabutin.
LoperamideThe metabolism of Loperamide can be increased when combined with Rifabutin.
LopinavirThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Lopinavir.
LopinavirThe metabolism of Lopinavir can be increased when combined with Rifabutin.
LoratadineThe metabolism of Loratadine can be increased when combined with Rifabutin.
LorcaserinThe metabolism of Lorcaserin can be increased when combined with Rifabutin.
LosartanThe metabolism of Losartan can be increased when combined with Rifabutin.
LovastatinThe metabolism of Lovastatin can be increased when combined with Rifabutin.
LuliconazoleThe serum concentration of Rifabutin can be increased when it is combined with Luliconazole.
LumefantrineThe serum concentration of Lumefantrine can be decreased when it is combined with Rifabutin.
LurasidoneThe serum concentration of Lurasidone can be decreased when it is combined with Rifabutin.
MacitentanThe serum concentration of Macitentan can be decreased when it is combined with Rifabutin.
MaravirocThe serum concentration of Maraviroc can be decreased when it is combined with Rifabutin.
MebendazoleThe metabolism of Mebendazole can be increased when combined with Rifabutin.
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be increased when combined with Rifabutin.
MedrysoneThe serum concentration of Medrysone can be decreased when it is combined with Rifabutin.
MefloquineThe metabolism of Mefloquine can be increased when combined with Rifabutin.
MelengestrolThe serum concentration of Melengestrol can be decreased when it is combined with Rifabutin.
MeloxicamThe metabolism of Meloxicam can be increased when combined with Rifabutin.
MethadoneThe metabolism of Methadone can be increased when combined with Rifabutin.
MethaqualoneThe metabolism of Methaqualone can be increased when combined with Rifabutin.
MethoxsalenThe metabolism of Methoxsalen can be increased when combined with Rifabutin.
MethoxyfluraneThe metabolism of Methoxyflurane can be increased when combined with Rifabutin.
MethylprednisoloneThe serum concentration of Methylprednisolone can be decreased when it is combined with Rifabutin.
MethyltestosteroneThe metabolism of Methyltestosterone can be increased when combined with Rifabutin.
MetronidazoleThe metabolism of Metronidazole can be increased when combined with Rifabutin.
MexiletineThe metabolism of Mexiletine can be increased when combined with Rifabutin.
MianserinThe metabolism of Mianserin can be increased when combined with Rifabutin.
MibefradilThe metabolism of Mibefradil can be increased when combined with Rifabutin.
MiconazoleThe metabolism of Miconazole can be increased when combined with Rifabutin.
MidazolamThe metabolism of Midazolam can be increased when combined with Rifabutin.
MifepristoneThe serum concentration of Mifepristone can be decreased when it is combined with Rifabutin.
MifepristoneThe metabolism of Rifabutin can be decreased when combined with Mifepristone.
MirabegronThe metabolism of Mirabegron can be increased when combined with Rifabutin.
MirtazapineThe metabolism of Mirtazapine can be increased when combined with Rifabutin.
MitotaneThe serum concentration of Rifabutin can be decreased when it is combined with Mitotane.
ModafinilThe serum concentration of Rifabutin can be decreased when it is combined with Modafinil.
ModafinilThe metabolism of Modafinil can be increased when combined with Rifabutin.
MometasoneThe serum concentration of Mometasone can be decreased when it is combined with Rifabutin.
MontelukastThe metabolism of Montelukast can be increased when combined with Rifabutin.
MorphineThe metabolism of Morphine can be increased when combined with Rifabutin.
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be increased when combined with Rifabutin.
NafcillinThe serum concentration of Rifabutin can be decreased when it is combined with Nafcillin.
NaloxegolThe serum concentration of Naloxegol can be decreased when it is combined with Rifabutin.
NaloxoneThe metabolism of Naloxone can be increased when combined with Rifabutin.
NateglinideThe metabolism of Nateglinide can be increased when combined with Rifabutin.
NefazodoneThe metabolism of Nefazodone can be increased when combined with Rifabutin.
NelfinavirThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Nelfinavir.
NelfinavirThe metabolism of Nelfinavir can be increased when combined with Rifabutin.
NetupitantThe serum concentration of Rifabutin can be increased when it is combined with Netupitant.
NetupitantThe serum concentration of Netupitant can be decreased when it is combined with Rifabutin.
NevirapineThe serum concentration of Nevirapine can be decreased when it is combined with Rifabutin.
NevirapineThe metabolism of Rifabutin can be decreased when combined with Nevirapine.
NicardipineThe metabolism of Nicardipine can be increased when combined with Rifabutin.
NicotineThe metabolism of Nicotine can be increased when combined with Rifabutin.
NifedipineThe serum concentration of Nifedipine can be decreased when it is combined with Rifabutin.
NilotinibThe serum concentration of Nilotinib can be decreased when it is combined with Rifabutin.
NilotinibThe metabolism of Rifabutin can be decreased when combined with Nilotinib.
NilvadipineThe metabolism of Nilvadipine can be increased when combined with Rifabutin.
NimodipineThe serum concentration of Nimodipine can be decreased when it is combined with Rifabutin.
NintedanibThe serum concentration of Nintedanib can be decreased when it is combined with Rifabutin.
NisoldipineThe serum concentration of Nisoldipine can be decreased when it is combined with Rifabutin.
NitrazepamThe metabolism of Nitrazepam can be increased when combined with Rifabutin.
NitrendipineThe metabolism of Nitrendipine can be increased when combined with Rifabutin.
NorethisteroneThe metabolism of Norethisterone can be increased when combined with Rifabutin.
NorgestrelThe metabolism of Norgestrel can be increased when combined with Rifabutin.
NortriptylineThe metabolism of Nortriptyline can be increased when combined with Rifabutin.
OlaparibThe serum concentration of Olaparib can be decreased when it is combined with Rifabutin.
OlaparibThe metabolism of Rifabutin can be decreased when combined with Olaparib.
OlopatadineThe metabolism of Olopatadine can be increased when combined with Rifabutin.
OmeprazoleThe metabolism of Omeprazole can be increased when combined with Rifabutin.
OndansetronThe metabolism of Ondansetron can be increased when combined with Rifabutin.
OrphenadrineThe metabolism of Orphenadrine can be increased when combined with Rifabutin.
OsimertinibThe serum concentration of Rifabutin can be increased when it is combined with Osimertinib.
OsimertinibThe serum concentration of Osimertinib can be decreased when it is combined with Rifabutin.
OspemifeneThe metabolism of Ospemifene can be increased when combined with Rifabutin.
OxazepamThe metabolism of Oxazepam can be increased when combined with Rifabutin.
OxybutyninThe metabolism of Oxybutynin can be increased when combined with Rifabutin.
OxycodoneThe metabolism of Oxycodone can be increased when combined with Rifabutin.
OxymorphoneThe metabolism of Oxymorphone can be increased when combined with Rifabutin.
PaclitaxelThe metabolism of Paclitaxel can be increased when combined with Rifabutin.
PalbociclibThe serum concentration of Rifabutin can be increased when it is combined with Palbociclib.
PalbociclibThe serum concentration of Palbociclib can be decreased when it is combined with Rifabutin.
PalonosetronThe metabolism of Palonosetron can be increased when combined with Rifabutin.
PanobinostatThe serum concentration of Panobinostat can be decreased when it is combined with Rifabutin.
PantoprazoleThe metabolism of Pantoprazole can be increased when combined with Rifabutin.
ParamethadioneThe metabolism of Paramethadione can be increased when combined with Rifabutin.
ParamethasoneThe serum concentration of Paramethasone can be decreased when it is combined with Rifabutin.
ParecoxibThe metabolism of Parecoxib can be increased when combined with Rifabutin.
ParicalcitolThe metabolism of Paricalcitol can be increased when combined with Rifabutin.
ParitaprevirThe metabolism of Paritaprevir can be increased when combined with Rifabutin.
PazopanibThe serum concentration of Pazopanib can be decreased when it is combined with Rifabutin.
Peginterferon alfa-2bThe serum concentration of Rifabutin can be increased when it is combined with Peginterferon alfa-2b.
PentamidineThe metabolism of Pentamidine can be increased when combined with Rifabutin.
PentobarbitalThe metabolism of Rifabutin can be increased when combined with Pentobarbital.
PerampanelThe serum concentration of Perampanel can be decreased when it is combined with Rifabutin.
PergolideThe metabolism of Pergolide can be increased when combined with Rifabutin.
PerhexilineThe metabolism of Perhexiline can be increased when combined with Rifabutin.
PermethrinThe metabolism of Permethrin can be increased when combined with Rifabutin.
PerphenazineThe metabolism of Perphenazine can be increased when combined with Rifabutin.
PethidineThe metabolism of Pethidine can be increased when combined with Rifabutin.
PhenacetinThe metabolism of Phenacetin can be increased when combined with Rifabutin.
PhenobarbitalThe metabolism of Rifabutin can be increased when combined with Phenobarbital.
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be increased when combined with Rifabutin.
PhenprocoumonThe metabolism of Phenprocoumon can be increased when combined with Rifabutin.
PhenytoinThe metabolism of Rifabutin can be increased when combined with Phenytoin.
Picosulfuric acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Rifabutin.
PilocarpineThe metabolism of Pilocarpine can be increased when combined with Rifabutin.
PimecrolimusThe metabolism of Pimecrolimus can be increased when combined with Rifabutin.
PimozideThe metabolism of Pimozide can be increased when combined with Rifabutin.
PinacidilThe metabolism of Pinacidil can be increased when combined with Rifabutin.
PioglitazoneThe metabolism of Pioglitazone can be increased when combined with Rifabutin.
PipotiazineThe metabolism of Pipotiazine can be increased when combined with Rifabutin.
PodofiloxThe metabolism of Podofilox can be increased when combined with Rifabutin.
PomalidomideThe metabolism of Pomalidomide can be increased when combined with Rifabutin.
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with Rifabutin.
PosaconazoleThe metabolism of Posaconazole can be increased when combined with Rifabutin.
PrasugrelThe metabolism of Prasugrel can be increased when combined with Rifabutin.
PravastatinThe metabolism of Pravastatin can be increased when combined with Rifabutin.
PrazepamThe metabolism of Prazepam can be increased when combined with Rifabutin.
PraziquantelThe serum concentration of Praziquantel can be decreased when it is combined with Rifabutin.
PrednicarbateThe serum concentration of Prednicarbate can be decreased when it is combined with Rifabutin.
PrednisoloneThe serum concentration of Prednisolone can be decreased when it is combined with Rifabutin.
PrednisoneThe serum concentration of Prednisone can be decreased when it is combined with Rifabutin.
PregnenoloneThe serum concentration of Pregnenolone can be decreased when it is combined with Rifabutin.
PrimaquineThe metabolism of Primaquine can be increased when combined with Rifabutin.
PrimidoneThe metabolism of Rifabutin can be increased when combined with Primidone.
ProchlorperazineThe metabolism of Prochlorperazine can be increased when combined with Rifabutin.
ProgesteroneThe metabolism of Progesterone can be increased when combined with Rifabutin.
ProguanilThe metabolism of Proguanil can be increased when combined with Rifabutin.
PromazineThe metabolism of Promazine can be increased when combined with Rifabutin.
PropafenoneThe serum concentration of Propafenone can be decreased when it is combined with Rifabutin.
PropofolThe metabolism of Propofol can be increased when combined with Rifabutin.
PropranololThe metabolism of Propranolol can be increased when combined with Rifabutin.
PyrazinamideThe metabolism of Pyrazinamide can be increased when combined with Rifabutin.
QuazepamThe metabolism of Quazepam can be increased when combined with Rifabutin.
QuetiapineThe serum concentration of Quetiapine can be decreased when it is combined with Rifabutin.
QuinacrineThe metabolism of Quinacrine can be increased when combined with Rifabutin.
QuinidineThe metabolism of Quinidine can be increased when combined with Rifabutin.
QuinineThe metabolism of Quinine can be increased when combined with Rifabutin.
RabeprazoleThe metabolism of Rabeprazole can be increased when combined with Rifabutin.
RaloxifeneThe metabolism of Raloxifene can be increased when combined with Rifabutin.
RaltegravirThe serum concentration of Raltegravir can be decreased when it is combined with Rifabutin.
RamelteonThe metabolism of Ramelteon can be increased when combined with Rifabutin.
RanolazineThe serum concentration of Ranolazine can be decreased when it is combined with Rifabutin.
RanolazineThe metabolism of Rifabutin can be decreased when combined with Ranolazine.
ReboxetineThe metabolism of Reboxetine can be increased when combined with Rifabutin.
RegorafenibThe serum concentration of Regorafenib can be decreased when it is combined with Rifabutin.
RepaglinideThe metabolism of Repaglinide can be increased when combined with Rifabutin.
RetapamulinThe metabolism of Retapamulin can be increased when combined with Rifabutin.
RifampicinThe metabolism of Rifampicin can be increased when combined with Rifabutin.
RifapentineThe metabolism of Rifabutin can be increased when combined with Rifapentine.
RilpivirineThe serum concentration of Rilpivirine can be decreased when it is combined with Rifabutin.
RimexoloneThe serum concentration of Rimexolone can be decreased when it is combined with Rifabutin.
RimonabantThe metabolism of Rimonabant can be increased when combined with Rifabutin.
RiociguatThe metabolism of Riociguat can be increased when combined with Rifabutin.
RisperidoneThe metabolism of Risperidone can be increased when combined with Rifabutin.
RitonavirThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Ritonavir.
RitonavirThe metabolism of Ritonavir can be increased when combined with Rifabutin.
RivaroxabanThe serum concentration of Rivaroxaban can be decreased when it is combined with Rifabutin.
RofecoxibThe metabolism of Rofecoxib can be increased when combined with Rifabutin.
RoflumilastThe serum concentration of Roflumilast can be decreased when it is combined with Rifabutin.
RolapitantThe serum concentration of Rolapitant can be decreased when it is combined with Rifabutin.
RomidepsinThe serum concentration of Romidepsin can be decreased when it is combined with Rifabutin.
RopiniroleThe metabolism of Ropinirole can be increased when combined with Rifabutin.
RopivacaineThe metabolism of Ropivacaine can be increased when combined with Rifabutin.
RosuvastatinThe metabolism of Rosuvastatin can be increased when combined with Rifabutin.
RotigotineThe metabolism of Rotigotine can be increased when combined with Rifabutin.
RoxithromycinThe metabolism of Roxithromycin can be increased when combined with Rifabutin.
RuxolitinibThe metabolism of Ruxolitinib can be increased when combined with Rifabutin.
SalmeterolThe metabolism of Salmeterol can be increased when combined with Rifabutin.
SaquinavirThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Saquinavir.
SaquinavirThe metabolism of Saquinavir can be increased when combined with Rifabutin.
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Rifabutin.
SelegilineThe metabolism of Selegiline can be increased when combined with Rifabutin.
SelexipagThe metabolism of Selexipag can be increased when combined with Rifabutin.
SeratrodastThe metabolism of Seratrodast can be increased when combined with Rifabutin.
SertindoleThe metabolism of Sertindole can be increased when combined with Rifabutin.
SertralineThe metabolism of Sertraline can be increased when combined with Rifabutin.
SevofluraneThe metabolism of Sevoflurane can be increased when combined with Rifabutin.
SibutramineThe metabolism of Sibutramine can be increased when combined with Rifabutin.
SildenafilThe metabolism of Sildenafil can be increased when combined with Rifabutin.
SilodosinThe metabolism of Silodosin can be increased when combined with Rifabutin.
SiltuximabThe serum concentration of Rifabutin can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Rifabutin can be increased when it is combined with Simeprevir.
SimeprevirThe serum concentration of Simeprevir can be decreased when it is combined with Rifabutin.
SimvastatinThe metabolism of Simvastatin can be increased when combined with Rifabutin.
SirolimusThe metabolism of Sirolimus can be increased when combined with Rifabutin.
SitagliptinThe metabolism of Sitagliptin can be increased when combined with Rifabutin.
SofosbuvirThe serum concentration of Sofosbuvir can be decreased when it is combined with Rifabutin.
SolifenacinThe metabolism of Solifenacin can be increased when combined with Rifabutin.
SonidegibThe serum concentration of Sonidegib can be decreased when it is combined with Rifabutin.
SorafenibThe serum concentration of Sorafenib can be decreased when it is combined with Rifabutin.
SpiramycinThe metabolism of Spiramycin can be increased when combined with Rifabutin.
St. John's WortThe serum concentration of Rifabutin can be decreased when it is combined with St. John's Wort.
StiripentolThe serum concentration of Rifabutin can be increased when it is combined with Stiripentol.
SufentanilThe metabolism of Sufentanil can be increased when combined with Rifabutin.
SulfadiazineThe metabolism of Sulfadiazine can be increased when combined with Rifabutin.
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be increased when combined with Rifabutin.
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be increased when combined with Rifabutin.
SulfisoxazoleThe metabolism of Rifabutin can be decreased when combined with Sulfisoxazole.
SunitinibThe serum concentration of Sunitinib can be decreased when it is combined with Rifabutin.
SuvorexantThe serum concentration of Suvorexant can be decreased when it is combined with Rifabutin.
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be increased when combined with Rifabutin.
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be increased when combined with Rifabutin.
TacrolimusThe metabolism of Tacrolimus can be increased when combined with Rifabutin.
TadalafilThe serum concentration of Tadalafil can be decreased when it is combined with Rifabutin.
TamoxifenThe metabolism of Tamoxifen can be increased when combined with Rifabutin.
TamsulosinThe metabolism of Tamsulosin can be increased when combined with Rifabutin.
TasimelteonThe serum concentration of Tasimelteon can be decreased when it is combined with Rifabutin.
TasosartanThe metabolism of Tasosartan can be increased when combined with Rifabutin.
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be increased when combined with Rifabutin.
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Rifabutin.
TelaprevirThe metabolism of Rifabutin can be decreased when combined with Telaprevir.
TelithromycinThe metabolism of Telithromycin can be increased when combined with Rifabutin.
TemazepamThe metabolism of Temazepam can be increased when combined with Rifabutin.
TemsirolimusThe metabolism of Temsirolimus can be increased when combined with Rifabutin.
TeniposideThe metabolism of Teniposide can be increased when combined with Rifabutin.
TenofovirThe metabolism of Rifabutin can be decreased when combined with Tenofovir.
TerbinafineThe metabolism of Terbinafine can be increased when combined with Rifabutin.
TerfenadineThe metabolism of Terfenadine can be increased when combined with Rifabutin.
TeriflunomideThe serum concentration of Rifabutin can be decreased when it is combined with Teriflunomide.
TesmilifeneThe metabolism of Tesmilifene can be increased when combined with Rifabutin.
TestosteroneThe metabolism of Testosterone can be increased when combined with Rifabutin.
TetracyclineThe metabolism of Tetracycline can be increased when combined with Rifabutin.
TheophyllineThe metabolism of Theophylline can be increased when combined with Rifabutin.
ThiotepaThe metabolism of Thiotepa can be increased when combined with Rifabutin.
TiagabineThe metabolism of Tiagabine can be increased when combined with Rifabutin.
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Rifabutin resulting in a loss in efficacy.
TiclopidineThe metabolism of Ticlopidine can be increased when combined with Rifabutin.
TinidazoleThe metabolism of Tinidazole can be increased when combined with Rifabutin.
TiotropiumThe metabolism of Tiotropium can be increased when combined with Rifabutin.
TipranavirThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Tipranavir.
TipranavirThe metabolism of Tipranavir can be increased when combined with Rifabutin.
TixocortolThe serum concentration of Tixocortol can be decreased when it is combined with Rifabutin.
TocilizumabThe serum concentration of Rifabutin can be decreased when it is combined with Tocilizumab.
TofacitinibThe serum concentration of Tofacitinib can be decreased when it is combined with Rifabutin.
TolterodineThe metabolism of Tolterodine can be increased when combined with Rifabutin.
TolvaptanThe serum concentration of Tolvaptan can be decreased when it is combined with Rifabutin.
ToremifeneThe serum concentration of Toremifene can be decreased when it is combined with Rifabutin.
TrabectedinThe serum concentration of Trabectedin can be decreased when it is combined with Rifabutin.
TramadolThe metabolism of Tramadol can be increased when combined with Rifabutin.
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be increased when combined with Rifabutin.
TrazodoneThe metabolism of Trazodone can be increased when combined with Rifabutin.
TretinoinThe metabolism of Tretinoin can be increased when combined with Rifabutin.
TriamcinoloneThe serum concentration of Triamcinolone can be decreased when it is combined with Rifabutin.
TriazolamThe metabolism of Triazolam can be increased when combined with Rifabutin.
TrimethadioneThe metabolism of Trimethadione can be increased when combined with Rifabutin.
TrimethoprimThe metabolism of Trimethoprim can be increased when combined with Rifabutin.
TrimipramineThe metabolism of Trimipramine can be increased when combined with Rifabutin.
TroglitazoneThe metabolism of Troglitazone can be increased when combined with Rifabutin.
TroleandomycinThe metabolism of Troleandomycin can be increased when combined with Rifabutin.
UdenafilThe metabolism of Udenafil can be increased when combined with Rifabutin.
UlipristalThe serum concentration of Ulipristal can be decreased when it is combined with Rifabutin.
ValdecoxibThe metabolism of Valdecoxib can be increased when combined with Rifabutin.
VandetanibThe serum concentration of Vandetanib can be decreased when it is combined with Rifabutin.
VanoxerineThe metabolism of Vanoxerine can be increased when combined with Rifabutin.
VardenafilThe metabolism of Vardenafil can be increased when combined with Rifabutin.
VemurafenibThe serum concentration of Rifabutin can be increased when it is combined with Vemurafenib.
VemurafenibThe serum concentration of Vemurafenib can be decreased when it is combined with Rifabutin.
VenlafaxineThe metabolism of Venlafaxine can be increased when combined with Rifabutin.
VerapamilThe metabolism of Verapamil can be increased when combined with Rifabutin.
VicrivirocThe metabolism of Vicriviroc can be increased when combined with Rifabutin.
VilanterolThe metabolism of Vilanterol can be increased when combined with Rifabutin.
VilazodoneThe serum concentration of Vilazodone can be decreased when it is combined with Rifabutin.
VinblastineThe metabolism of Vinblastine can be increased when combined with Rifabutin.
VincristineThe serum concentration of Vincristine can be decreased when it is combined with Rifabutin.
VindesineThe metabolism of Vindesine can be increased when combined with Rifabutin.
VinorelbineThe metabolism of Vinorelbine can be increased when combined with Rifabutin.
VismodegibThe metabolism of Vismodegib can be increased when combined with Rifabutin.
VorapaxarThe serum concentration of Vorapaxar can be decreased when it is combined with Rifabutin.
VoriconazoleThe metabolism of Voriconazole can be increased when combined with Rifabutin.
VortioxetineThe serum concentration of Vortioxetine can be decreased when it is combined with Rifabutin.
WarfarinThe metabolism of Warfarin can be increased when combined with Rifabutin.
YohimbineThe metabolism of Yohimbine can be increased when combined with Rifabutin.
ZafirlukastThe metabolism of Zafirlukast can be increased when combined with Rifabutin.
ZalcitabineThe metabolism of Zalcitabine can be increased when combined with Rifabutin.
ZaleplonThe serum concentration of Zaleplon can be decreased when it is combined with Rifabutin.
ZidovudineThe metabolism of Zidovudine can be increased when combined with Rifabutin.
ZileutonThe metabolism of Zileuton can be increased when combined with Rifabutin.
ZiprasidoneThe metabolism of Ziprasidone can be increased when combined with Rifabutin.
ZolpidemThe metabolism of Zolpidem can be increased when combined with Rifabutin.
ZomepiracThe metabolism of Zomepirac can be increased when combined with Rifabutin.
ZonisamideThe metabolism of Zonisamide can be increased when combined with Rifabutin.
ZopicloneThe metabolism of Zopiclone can be increased when combined with Rifabutin.
ZuclopenthixolThe serum concentration of Zuclopenthixol can be decreased when it is combined with Rifabutin.
Food Interactions
  • High-fat meals slow the rate of absorption.
  • Take with food to reduce irritation.

Targets

Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
yes
Actions
inhibitor
General Function:
Zinc ion binding
Specific Function:
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit plays an important role in subunit assembly since its dimerization is the first step in the sequential assembly of subunits to form the holoenzyme.
Gene Name:
rpoA
Uniprot ID:
P0A7Z4
Molecular Weight:
36511.35 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Maddix DS, Tallian KB, Mead PS: Rifabutin: a review with emphasis on its role in the prevention of disseminated Mycobacterium avium complex infection. Ann Pharmacother. 1994 Nov;28(11):1250-4. [PubMed:7849340 ]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
yes
Actions
inhibitor
General Function:
Ribonucleoside binding
Specific Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Gene Name:
rpoB
Uniprot ID:
P0A8V2
Molecular Weight:
150631.165 Da
References
  1. Maddix DS, Tallian KB, Mead PS: Rifabutin: a review with emphasis on its role in the prevention of disseminated Mycobacterium avium complex infection. Ann Pharmacother. 1994 Nov;28(11):1250-4. [PubMed:7849340 ]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
yes
Actions
inhibitor
General Function:
Dna-directed rna polymerase activity
Specific Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Gene Name:
rpoC
Uniprot ID:
P0A8T7
Molecular Weight:
155158.84 Da
References
  1. Maddix DS, Tallian KB, Mead PS: Rifabutin: a review with emphasis on its role in the prevention of disseminated Mycobacterium avium complex infection. Ann Pharmacother. 1994 Nov;28(11):1250-4. [PubMed:7849340 ]
Kind
Protein
Organism
Human
Pharmacological action
no
Actions
other/unknown
General Function:
Tpr domain binding
Specific Function:
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with v...
Gene Name:
HSP90AA1
Uniprot ID:
P07900
Molecular Weight:
84659.015 Da
References
  1. Schnaider T, Somogyi J, Csermely P, Szamel M: The Hsp90-specific inhibitor geldanamycin selectively disrupts kinase-mediated signaling events of T-lymphocyte activation. Cell Stress Chaperones. 2000 Jan;5(1):52-61. [PubMed:10701840 ]
  2. Neckers L, Schulte TW, Mimnaugh E: Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity. Invest New Drugs. 1999;17(4):361-73. [PubMed:10759403 ]
  3. Srethapakdi M, Liu F, Tavorath R, Rosen N: Inhibition of Hsp90 function by ansamycins causes retinoblastoma gene product-dependent G1 arrest. Cancer Res. 2000 Jul 15;60(14):3940-6. [PubMed:10919672 ]
  4. Munster PN, Srethapakdi M, Moasser MM, Rosen N: Inhibition of heat shock protein 90 function by ansamycins causes the morphological and functional differentiation of breast cancer cells. Cancer Res. 2001 Apr 1;61(7):2945-52. [PubMed:11306472 ]
  5. Yang J, Yang JM, Iannone M, Shih WJ, Lin Y, Hait WN: Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to inhibit glioblastoma by geldanamycin. Cancer Res. 2001 May 15;61(10):4010-6. [PubMed:11358819 ]
Kind
Protein
Organism
Human
Pharmacological action
no
Actions
other/unknown
General Function:
Virion binding
Specific Function:
Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.
Gene Name:
HSP90B1
Uniprot ID:
P14625
Molecular Weight:
92468.06 Da
References
  1. Barzilay E, Ben-Califa N, Supino-Rosin L, Kashman Y, Hirschberg K, Elazar Z, Neumann D: Geldanamycin-associated inhibition of intracellular trafficking is attributed to a co-purified activity. J Biol Chem. 2004 Feb 20;279(8):6847-52. Epub 2003 Dec 1. [PubMed:14660597 ]
  2. Chavany C, Mimnaugh E, Miller P, Bitton R, Nguyen P, Trepel J, Whitesell L, Schnur R, Moyer J, Neckers L: p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2. J Biol Chem. 1996 Mar 1;271(9):4974-7. [PubMed:8617772 ]
  3. Lawson B, Brewer JW, Hendershot LM: Geldanamycin, an hsp90/GRP94-binding drug, induces increased transcription of endoplasmic reticulum (ER) chaperones via the ER stress pathway. J Cell Physiol. 1998 Feb;174(2):170-8. [PubMed:9428803 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Ekins S, Bravi G, Wikel JH, Wrighton SA: Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates. J Pharmacol Exp Ther. 1999 Oct;291(1):424-33. [PubMed:10490933 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23