Remarkable potential of the alpha-aminophosphonate/phosphinate structural motif in medicinal chemistry.

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Mucha A, Kafarski P, Berlicki L

Remarkable potential of the alpha-aminophosphonate/phosphinate structural motif in medicinal chemistry.

J Med Chem. 2011 Sep 8;54(17):5955-80. doi: 10.1021/jm200587f. Epub 2011 Aug 5.

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21780776 [ View in PubMed

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DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Alendronic acid	Farnesyl pyrophosphate synthase	IC 50 (nM)	50	N/A	N/A	Details
Pamidronic acid	Farnesyl pyrophosphate synthase	IC 50 (nM)	200	N/A	N/A	Details
Risedronic acid	Farnesyl pyrophosphate synthase	IC 50 (nM)	10	N/A	N/A	Details
Zoledronic acid	Farnesyl pyrophosphate synthase	IC 50 (nM)	3	N/A	N/A	Details