4-Amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)amino]carbonyl]-piperazinyl]-6, 7-dimethoxyquinazoline (L-765,314): a potent and selective alpha1b adrenergic receptor antagonist.

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Patane MA, Scott AL, Broten TP, Chang RS, Ransom RW, DiSalvo J, Forray C, Bock MG

4-Amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)amino]carbonyl]-piperazinyl]-6, 7-dimethoxyquinazoline (L-765,314): a potent and selective alpha1b adrenergic receptor antagonist.

J Med Chem. 1998 Apr 9;41(8):1205-8.

PubMed ID
9548811 [ View in PubMed
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Abstract

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DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
PrazosinAlpha-1A adrenergic receptorKi (nM)0.39N/AN/ADetails
PrazosinAlpha-1B adrenergic receptorKi (nM)0.21N/AN/ADetails
PrazosinAlpha-1D adrenergic receptorKi (nM)0.2N/AN/ADetails
TerazosinAlpha-1A adrenergic receptorKi (nM)4.2N/AN/ADetails
TerazosinAlpha-1B adrenergic receptorKi (nM)1.2N/AN/ADetails
TerazosinAlpha-1D adrenergic receptorKi (nM)2N/AN/ADetails