Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor.

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Barbey S, Goossens L, Taverne T, Cornet J, Choesmel V, Rouaud C, Gimeno G, Yannic-Arnoult S, Michaux C, Charlier C, Houssin R, Henichart JP

Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor.

Bioorg Med Chem Lett. 2002 Mar 11;12(5):779-82.

PubMed ID

11859001 [ View in PubMed

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Abstract

Dual COX-2/5-LO inhibitors are described as potential new therapeutic agents for inflammatory diseases. A surprisingly potent effect of a 5-LO pharmacophoric group on the COX-2 inhibition is presented as well as pharmacological in vitro and in vivo results.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Rofecoxib	Prostaglandin G/H synthase 2	IC 50 (nM)	1	N/A	N/A	Details
Zileuton	Arachidonate 5-lipoxygenase	IC 50 (nM)	2900	N/A	N/A	Details