New NSAIDs-NO hybrid molecules with antiproliferative properties on human prostatic cancer cell lines.

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Beziere N, Goossens L, Pommery J, Vezin H, Touati N, Henichart JP, Pommery N

New NSAIDs-NO hybrid molecules with antiproliferative properties on human prostatic cancer cell lines.

Bioorg Med Chem Lett. 2008 Aug 15;18(16):4655-7. doi: 10.1016/j.bmcl.2008.07.018. Epub 2008 Jul 10.

PubMed ID
18667313 [ View in PubMed
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Abstract

The design of profen hybrids containing a NO donor moiety connected to an aliphatic spacer led to compounds with a similar cyclooxygenase inhibition compared to their parent profen and with significant antiproliferative activities on PC3 cells. However, inhibition of COX-2 pathway alone did not seem sufficient to inhibit cancer cell proliferation, and NO-release in a time-dependent manner strongly contributes to this activity.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
CarprofenProstaglandin G/H synthase 2IC 50 (nM)38000N/AN/ADetails
KetoprofenProstaglandin G/H synthase 2IC 50 (nM)690N/AN/ADetails
SuprofenProstaglandin G/H synthase 2IC 50 (nM)2750N/AN/ADetails