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Identification
NameSecretin
Accession NumberDB00021  (BIOD00039, BTD00039)
TypeBiotech
GroupsApproved, Investigational
Description

This drug is the synthetic form of natural secretin. It is prepared using solid phase peptide synthesis. Secretin is a peptide hormone produced in the S cells of the duodenum. Its main effect is to regulate the pH of the small intestine’s contents through the control of gastric acid secretion and buffering with bicarbonate. It was the first hormone to be discovered.

Protein structureDb00021
Protein chemical formulaC130H219N43O42
Protein average weight3056.4000
Sequences
>DB00021 sequence
HSDGTFTSELSRLRDSARLQRLLQGLV
Download FASTA Format
SynonymsNot Available
Prescription ProductsNot Available
Generic Prescription ProductsNot Available
Over the Counter ProductsNot Available
International Brands
NameCompany
SecreFloRepligen Corp
SecremaxRepligen Corp
Brand mixturesNot Available
SaltsNot Available
Categories
CAS numberNot Available
Taxonomy
DescriptionNot Available
KingdomOrganic Compounds
Super ClassOrganic Acids
ClassCarboxylic Acids and Derivatives
Sub ClassAmino Acids, Peptides, and Analogues
Direct ParentPeptides
Alternative ParentsNot Available
SubstituentsNot Available
Molecular FrameworkNot Available
External DescriptorsNot Available
Pharmacology
IndicationFor diagnosis of pancreatic exocrine dysfunction and gastrinoma
PharmacodynamicsUsed in the diagnosis of pancreatic dysfunction or gastrinoma (stomach cancer), secretin is a hormone produced in the S cells of the duodenum in response to low local pH. It stimulates the secretion of bicarbonate from bicarbonate producing organs(liver, pancreas, Brunner's glands) when the pH drops below a set value. This helps neutralize the gastric acid entering the duodenum from the stomach. It also inhibits acid secretion from the stomach by reducing gastrin release from the G cells of the stomach.
Mechanism of actionSecretin binds to the secretin receptor found on the lining of S cells in the duodenum and G cells in the stomach. Binding leads to the secrection of bicarbonate or the reduction of the secretion of gastrin. Properly functioning organs (duodenum, pancreas and stomach) should be responsive to this hormone
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Pharmacoeconomics
Manufacturers
  • Ferring pharmaceuticals inc
  • Chirhoclin inc
Packagers
  • Professional Co.
Dosage formsNot Available
Prices
Unit descriptionCostUnit
Secretin-mannitol powder1.43USD g
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
hydrophobicity-0.463Not Available
isoelectric point9.45Not Available
References
Synthesis Reference

Martin Bickel, Rolf Geiger, Richard Leeb, Walter Petri, “Secretin preparations with intensified and protracted action, process for their manufacture, their use as well as dihydroxybenzoyl-L-tyrosine.” U.S. Patent US4302448, issued August, 1964.

US4302448
General ReferenceNot Available
External Links
ATC CodesV04CK01
AHFS CodesNot Available
PDB Entries
FDA labelNot Available
MSDSNot Available
Interactions
Drug Interactions
Drug
AclidiniumAnticholinergic Agents may diminish the therapeutic effect of Secretin.
AmitriptylineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
AmoxapineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
AtropineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
AzelastineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
BenzatropineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
BrompheniramineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
CarbinoxamineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
CetirizineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
ChlorphenamineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
ChlorpromazineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
ClemastineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
ClidiniumAnticholinergic Agents may diminish the therapeutic effect of Secretin.
ClomipramineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
ClozapineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
CyclizineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
CyclobenzaprineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
CyclopentolateAnticholinergic Agents may diminish the therapeutic effect of Secretin.
CyproheptadineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
DarifenacinAnticholinergic Agents may diminish the therapeutic effect of Secretin.
DesipramineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
DesloratadineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
DexbrompheniramineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
DicyclomineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
DifenoxinAnticholinergic Agents may diminish the therapeutic effect of Secretin.
DimenhydrinateAnticholinergic Agents may diminish the therapeutic effect of Secretin.
DiphenoxylateAnticholinergic Agents may diminish the therapeutic effect of Secretin.
DisopyramideAnticholinergic Agents may diminish the therapeutic effect of Secretin.
DoxylamineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
DroperidolAnticholinergic Agents may diminish the therapeutic effect of Secretin.
FenoterolAnticholinergic Agents may diminish the therapeutic effect of Secretin.
FesoterodineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
FexofenadineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
FlavoxateAnticholinergic Agents may diminish the therapeutic effect of Secretin.
FlupentixolAnticholinergic Agents may diminish the therapeutic effect of Secretin.
Fluticasone PropionateAnticholinergic Agents may diminish the therapeutic effect of Secretin.
GlycopyrrolateAnticholinergic Agents may diminish the therapeutic effect of Secretin.
HaloperidolAnticholinergic Agents may diminish the therapeutic effect of Secretin.
HydroxyzineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
HyoscyamineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
ImipramineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
Ipratropium bromideAnticholinergic Agents may diminish the therapeutic effect of Secretin.
IsocarboxazidAnticholinergic Agents may diminish the therapeutic effect of Secretin.
KetotifenAnticholinergic Agents may diminish the therapeutic effect of Secretin.
LevocabastineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
LevocetirizineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
LoratadineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
LoxapineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
MaprotilineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
MeclizineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
MepenzolateAnticholinergic Agents may diminish the therapeutic effect of Secretin.
MethotrimeprazineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
MoclobemideAnticholinergic Agents may diminish the therapeutic effect of Secretin.
NortriptylineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
OlanzapineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
OlopatadineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
OrphenadrineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
OxybutyninAnticholinergic Agents may diminish the therapeutic effect of Secretin.
PerphenazineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
PhenelzineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
PimozideAnticholinergic Agents may diminish the therapeutic effect of Secretin.
PizotifenAnticholinergic Agents may diminish the therapeutic effect of Secretin.
ProchlorperazineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
ProcyclidineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
PromazineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
PromethazineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
PropanthelineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
ProtriptylineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
QuetiapineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
RisperidoneAnticholinergic Agents may diminish the therapeutic effect of Secretin.
SalbutamolAnticholinergic Agents may diminish the therapeutic effect of Secretin.
ScopolamineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
SolifenacinAnticholinergic Agents may diminish the therapeutic effect of Secretin.
ThioridazineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
ThiothixeneAnticholinergic Agents may diminish the therapeutic effect of Secretin.
TiotropiumAnticholinergic Agents may diminish the therapeutic effect of Secretin.
TolterodineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
TranylcypromineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
TrifluoperazineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
TrihexyphenidylAnticholinergic Agents may diminish the therapeutic effect of Secretin.
TrimipramineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
TriprolidineAnticholinergic Agents may diminish the therapeutic effect of Secretin.
TrospiumAnticholinergic Agents may diminish the therapeutic effect of Secretin.
ZuclopenthixolAnticholinergic Agents may diminish the therapeutic effect of Secretin.
Food InteractionsNot Available

Targets

1. Secretin receptor

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: agonist

Components

Name UniProt ID Details
Secretin receptor P47872 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed

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Drug created on June 13, 2005 07:24 / Updated on September 13, 2013 10:48