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Identification
NameSecretin
Accession NumberDB00021  (BTD00039, BIOD00039)
TypeBiotech
GroupsApproved, Investigational
Description

This drug is the synthetic form of natural secretin. It is prepared using solid phase peptide synthesis. Secretin is a peptide hormone produced in the S cells of the duodenum. Its main effect is to regulate the pH of the small intestine’s contents through the control of gastric acid secretion and buffering with bicarbonate. It was the first hormone to be discovered.

Protein structureDb00021
Related Articles
Protein chemical formulaC130H219N43O42
Protein average weight3056.4 Da
Sequences
>DB00021 sequence
HSDGTFTSELSRLRDSARLQRLLQGLV
Download FASTA Format
SynonymsNot Available
External Identifiers Not Available
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Secretin Inj 75unit/vialpowder for solution75 unitintravenousFerring Inc1990-12-311999-08-04Canada
Generic Prescription ProductsNot Available
Over the Counter ProductsNot Available
International Brands
NameCompany
SecreFloRepligen Corp
SecremaxRepligen Corp
Brand mixturesNot Available
SaltsNot Available
Categories
UNII88C55N56UU
CAS numberNot Available
Taxonomy
DescriptionNot Available
KingdomOrganic Compounds
Super ClassOrganic Acids
ClassCarboxylic Acids and Derivatives
Sub ClassAmino Acids, Peptides, and Analogues
Direct ParentPeptides
Alternative ParentsNot Available
SubstituentsNot Available
Molecular FrameworkNot Available
External DescriptorsNot Available
Pharmacology
IndicationFor diagnosis of pancreatic exocrine dysfunction and gastrinoma
PharmacodynamicsUsed in the diagnosis of pancreatic dysfunction or gastrinoma (stomach cancer), secretin is a hormone produced in the S cells of the duodenum in response to low local pH. It stimulates the secretion of bicarbonate from bicarbonate producing organs(liver, pancreas, Brunner's glands) when the pH drops below a set value. This helps neutralize the gastric acid entering the duodenum from the stomach. It also inhibits acid secretion from the stomach by reducing gastrin release from the G cells of the stomach.
Mechanism of actionSecretin binds to the secretin receptor found on the lining of S cells in the duodenum and G cells in the stomach. Binding leads to the secrection of bicarbonate or the reduction of the secretion of gastrin. Properly functioning organs (duodenum, pancreas and stomach) should be responsive to this hormone
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Pharmacoeconomics
Manufacturers
  • Ferring pharmaceuticals inc
  • Chirhoclin inc
Packagers
  • Professional Co.
Dosage forms
FormRouteStrength
Powder for solutionintravenous75 unit
Prices
Unit descriptionCostUnit
Secretin-mannitol powder1.43USD g
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
hydrophobicity-0.463Not Available
isoelectric point9.45Not Available
References
Synthesis Reference

Martin Bickel, Rolf Geiger, Richard Leeb, Walter Petri, “Secretin preparations with intensified and protracted action, process for their manufacture, their use as well as dihydroxybenzoyl-L-tyrosine.” U.S. Patent US4302448, issued August, 1964.

US4302448
General ReferencesNot Available
External Links
ATC CodesV04CK01
AHFS CodesNot Available
PDB Entries
FDA labelNot Available
MSDSNot Available
Interactions
Drug Interactions
Drug
AclidiniumThe therapeutic efficacy of Secretin can be decreased when used in combination with Aclidinium.
AmitriptylineThe therapeutic efficacy of Secretin can be decreased when used in combination with Amitriptyline.
AmoxapineThe therapeutic efficacy of Secretin can be decreased when used in combination with Amoxapine.
AtropineThe therapeutic efficacy of Secretin can be decreased when used in combination with Atropine.
AzelastineThe therapeutic efficacy of Secretin can be decreased when used in combination with Azelastine.
BenzatropineThe therapeutic efficacy of Secretin can be decreased when used in combination with Benzatropine.
BrompheniramineThe therapeutic efficacy of Secretin can be decreased when used in combination with Brompheniramine.
CarbinoxamineThe therapeutic efficacy of Secretin can be decreased when used in combination with Carbinoxamine.
CetirizineThe therapeutic efficacy of Secretin can be decreased when used in combination with Cetirizine.
ChlorphenamineThe therapeutic efficacy of Secretin can be decreased when used in combination with Chlorphenamine.
ChlorpromazineThe therapeutic efficacy of Secretin can be decreased when used in combination with Chlorpromazine.
ClemastineThe therapeutic efficacy of Secretin can be decreased when used in combination with Clemastine.
ClomipramineThe therapeutic efficacy of Secretin can be decreased when used in combination with Clomipramine.
ClozapineThe therapeutic efficacy of Secretin can be decreased when used in combination with Clozapine.
CyclizineThe therapeutic efficacy of Secretin can be decreased when used in combination with Cyclizine.
CyclobenzaprineThe therapeutic efficacy of Secretin can be decreased when used in combination with Cyclobenzaprine.
CyclopentolateThe therapeutic efficacy of Secretin can be decreased when used in combination with Cyclopentolate.
CyproheptadineThe therapeutic efficacy of Secretin can be decreased when used in combination with Cyproheptadine.
DarifenacinThe therapeutic efficacy of Secretin can be decreased when used in combination with Darifenacin.
DesipramineThe therapeutic efficacy of Secretin can be decreased when used in combination with Desipramine.
DesloratadineThe therapeutic efficacy of Secretin can be decreased when used in combination with Desloratadine.
Dexchlorpheniramine maleateThe therapeutic efficacy of Secretin can be decreased when used in combination with Dexchlorpheniramine maleate.
DicyclomineThe therapeutic efficacy of Secretin can be decreased when used in combination with Dicyclomine.
DimenhydrinateThe therapeutic efficacy of Secretin can be decreased when used in combination with Dimenhydrinate.
DiphenhydramineThe therapeutic efficacy of Secretin can be decreased when used in combination with Diphenhydramine.
DisopyramideThe therapeutic efficacy of Secretin can be decreased when used in combination with Disopyramide.
DoxepinThe therapeutic efficacy of Secretin can be decreased when used in combination with Doxepin.
DoxylamineThe therapeutic efficacy of Secretin can be decreased when used in combination with Doxylamine.
DroperidolThe therapeutic efficacy of Secretin can be decreased when used in combination with Droperidol.
FesoterodineThe therapeutic efficacy of Secretin can be decreased when used in combination with Fesoterodine.
FexofenadineThe therapeutic efficacy of Secretin can be decreased when used in combination with Fexofenadine.
FlavoxateThe therapeutic efficacy of Secretin can be decreased when used in combination with Flavoxate.
FlupentixolThe therapeutic efficacy of Secretin can be decreased when used in combination with Flupentixol.
FluphenazineThe therapeutic efficacy of Secretin can be decreased when used in combination with Fluphenazine.
GlycopyrrolateThe therapeutic efficacy of Secretin can be decreased when used in combination with Glycopyrrolate.
HaloperidolThe therapeutic efficacy of Secretin can be decreased when used in combination with Haloperidol.
HomatropineThe therapeutic efficacy of Secretin can be decreased when used in combination with Homatropine.
HydroxyzineThe therapeutic efficacy of Secretin can be decreased when used in combination with Hydroxyzine.
HyoscyamineThe therapeutic efficacy of Secretin can be decreased when used in combination with Hyoscyamine.
ImipramineThe therapeutic efficacy of Secretin can be decreased when used in combination with Imipramine.
Ipratropium bromideThe therapeutic efficacy of Secretin can be decreased when used in combination with Ipratropium bromide.
IsocarboxazidThe therapeutic efficacy of Secretin can be decreased when used in combination with Isocarboxazid.
LevocabastineThe therapeutic efficacy of Secretin can be decreased when used in combination with Levocabastine.
LevocetirizineThe therapeutic efficacy of Secretin can be decreased when used in combination with Levocetirizine.
LoratadineThe therapeutic efficacy of Secretin can be decreased when used in combination with Loratadine.
LoxapineThe therapeutic efficacy of Secretin can be decreased when used in combination with Loxapine.
MaprotilineThe therapeutic efficacy of Secretin can be decreased when used in combination with Maprotiline.
MeclizineThe therapeutic efficacy of Secretin can be decreased when used in combination with Meclizine.
MepenzolateThe therapeutic efficacy of Secretin can be decreased when used in combination with Mepenzolate.
MethotrimeprazineThe therapeutic efficacy of Secretin can be decreased when used in combination with Methotrimeprazine.
MethscopolamineThe therapeutic efficacy of Secretin can be decreased when used in combination with Methscopolamine.
MoclobemideThe therapeutic efficacy of Secretin can be decreased when used in combination with Moclobemide.
NortriptylineThe therapeutic efficacy of Secretin can be decreased when used in combination with Nortriptyline.
OlanzapineThe therapeutic efficacy of Secretin can be decreased when used in combination with Olanzapine.
OlopatadineThe therapeutic efficacy of Secretin can be decreased when used in combination with Olopatadine.
OrphenadrineThe therapeutic efficacy of Secretin can be decreased when used in combination with Orphenadrine.
OxybutyninThe therapeutic efficacy of Secretin can be decreased when used in combination with Oxybutynin.
PerphenazineThe therapeutic efficacy of Secretin can be decreased when used in combination with Perphenazine.
PhenelzineThe therapeutic efficacy of Secretin can be decreased when used in combination with Phenelzine.
PimozideThe therapeutic efficacy of Secretin can be decreased when used in combination with Pimozide.
PizotifenThe therapeutic efficacy of Secretin can be decreased when used in combination with Pizotifen.
ProchlorperazineThe therapeutic efficacy of Secretin can be decreased when used in combination with Prochlorperazine.
ProcyclidineThe therapeutic efficacy of Secretin can be decreased when used in combination with Procyclidine.
PromazineThe therapeutic efficacy of Secretin can be decreased when used in combination with Promazine.
PromethazineThe therapeutic efficacy of Secretin can be decreased when used in combination with Promethazine.
PropanthelineThe therapeutic efficacy of Secretin can be decreased when used in combination with Propantheline.
ProtriptylineThe therapeutic efficacy of Secretin can be decreased when used in combination with Protriptyline.
QuetiapineThe therapeutic efficacy of Secretin can be decreased when used in combination with Quetiapine.
RisperidoneThe therapeutic efficacy of Secretin can be decreased when used in combination with Risperidone.
ScopolamineThe therapeutic efficacy of Secretin can be decreased when used in combination with Scopolamine.
Scopolamine butylbromideThe therapeutic efficacy of Secretin can be decreased when used in combination with Scopolamine butylbromide.
SolifenacinThe therapeutic efficacy of Secretin can be decreased when used in combination with Solifenacin.
ThioridazineThe therapeutic efficacy of Secretin can be decreased when used in combination with Thioridazine.
ThiothixeneThe therapeutic efficacy of Secretin can be decreased when used in combination with Thiothixene.
TiotropiumThe therapeutic efficacy of Secretin can be decreased when used in combination with Tiotropium.
TolterodineThe therapeutic efficacy of Secretin can be decreased when used in combination with Tolterodine.
TranylcypromineThe therapeutic efficacy of Secretin can be decreased when used in combination with Tranylcypromine.
TrifluoperazineThe therapeutic efficacy of Secretin can be decreased when used in combination with Trifluoperazine.
TrihexyphenidylThe therapeutic efficacy of Secretin can be decreased when used in combination with Trihexyphenidyl.
TrimethobenzamideThe therapeutic efficacy of Secretin can be decreased when used in combination with Trimethobenzamide.
TrimipramineThe therapeutic efficacy of Secretin can be decreased when used in combination with Trimipramine.
TriprolidineThe therapeutic efficacy of Secretin can be decreased when used in combination with Triprolidine.
TrospiumThe therapeutic efficacy of Secretin can be decreased when used in combination with Trospium.
UmeclidiniumThe therapeutic efficacy of Secretin can be decreased when used in combination with Umeclidinium.
ZuclopenthixolThe therapeutic efficacy of Secretin can be decreased when used in combination with Zuclopenthixol.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Secretin receptor activity
Specific Function:
This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Gene Name:
SCTR
Uniprot ID:
P47872
Molecular Weight:
50206.135 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
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Drug created on June 13, 2005 07:24 / Updated on March 14, 2016 09:57