DrugBank: Thyrotropin Alfa (DB00024)

targets (1)

Identification

Name

Thyrotropin Alfa

Accession Number

DB00024 (BIOD00020, BTD00020)

Type

biotech

Groups

approved

Description

Thyrotropin alfa is a heterodimeric glycoprotein comprised of two non-covalently linked subunits, an alpha subunit of 92 amino acid residues containing two N-linked glycosylation sites and a beta subunit of 118 residues containing one N-linked glycosylation site. The amino acid sequence of thyrotropin alfa is identical to that of human pituitary thyroid stimulating hormone.

Protein structure

Display: 3D Structure

Protein chemical formula

C₉₇₅H₁₅₁₃N₂₆₇O₃₀₄S₂₆

Protein average weight

22672.9000

Sequences

>Alpha chain
APDVQDCPECTLQENPFFSQPGAPILQCMGCCFSRAYPTPLRSKKTMLVQKNVTSESTCC
VAKSYNRVTVMGGFKVENHTACHCSTCYYHKS

>Beta chain
NSCELTNITIAIEKEECRFCISINTTWCAGYCYTRDLVYKDPARPKIQKTCTFKELVYET
VRVPGCAHHADSLYTYPVATQCHCGKCDSDSTDCTVRGLGPSYCSFGEMKE

FASTA

Synonyms

Follicle-stimulating hormone beta subunit
Follitropin beta chain precursor
FSH-B
FSH-beta

Salts

Not Available

Brand names

Name	Company
Thyrogen (Genzyme Inc)

Brand mixtures

Not Available

Categories

Diagnostic Agents

CAS number

9002-71-5

Taxonomy

Kingdom

Not Available

Classes

Not Available

Substructures

Not Available

Pharmacology

Indication

For detection of residueal or recurrent thyroid cancer

Pharmacodynamics

Binding of thyrotropin alfa to TSH receptors on normal thyroid epithelial cells or on well-differentiated thyroid cancer tissue stimulates iodine uptake and organification. Thyrogen is an exogenous source of human TSH that offers an additional diagnostic tool in the follow-up of patients with a history of well-differentiated thyroid cancer.

Mechanism of action

Thyrotropin Alfa binds to the thyrotropin receptors found on any residual thyroid cells or tissues. This stimulates radioactive iodine uptake for better radiodiagnostic imaging.

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half life

5 +/- 10 hrs

Clearance

Not Available

Toxicity

Not Available

Affected organisms

Humans and other mammals

Pathways

Not Available

Pharmacoeconomics

Manufacturers

Sanofi aventis us llc
Genzyme corp

Packagers

Dosage forms

Form	Route	Strength
Powder, for solution	Intramuscular

Prices

Unit description	Cost	Unit
Thyrogen 1.1 mg vial	1196.4 USD	vial

DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.

Patents

Country	Patent Number	Approved	Expires (estimated)
United States	5840566	1995-11-24	2015-11-24

Properties

State

liquid

Experimental Properties

Property	Value	Source
hydrophobicity	-0.330	Not Available
isoelectric point	7.50	Not Available

References

Synthesis Reference

Not Available

General Reference

Not Available

External Links

Resource	Link
UniProt	P01225
Genbank	M16647
PharmGKB	PA164746560
Drug Product Database	2246016
RxList	http://www.rxlist.com/cgi/generic2/thyrotropin.htm
Drugs.com	http://www.drugs.com/cdi/thyrotropin-alfa.html

ATC Codes

V04CJ01

AHFS Codes

36:60.00

PDB Entries

1FL7

FDA label

show (2.27 MB)

MSDS

Not Available

Interactions

Drug Interactions

Searched, but no interactions found.

Food Interactions

Not Available

Targets
1. Thyrotropin receptor Pharmacological action: yes Actions: agonist Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5) Organism class: human UniProt ID: P16473 Gene: TSHR Protein Sequence: FASTA Gene Sequence: FASTA SNPs: SNPJam Report References: Szkudlinski MW: Recombinant human thyrotropins of the twenty-first century. Expert Opin Pharmacother. 2004 Dec;5(12):2435-40. Pubmed Conway GS: Clinical manifestations of genetic defects affecting gonadotrophins and their receptors. Clin Endocrinol (Oxf). 1996 Dec;45(6):657-63. Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed

Targets

1. Thyrotropin receptor

Pharmacological action: yes
Actions: agonist

Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5)

Organism class: human
UniProt ID: P16473 Link_out

Gene: TSHR Link_out

Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:

Szkudlinski MW: Recombinant human thyrotropins of the twenty-first century. Expert Opin Pharmacother. 2004 Dec;5(12):2435-40. Pubmed
Conway GS: Clinical manifestations of genetic defects affecting gonadotrophins and their receptors. Clin Endocrinol (Oxf). 1996 Dec;45(6):657-63. Pubmed
Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed

Comments

Drug created on June 13, 2005 07:24 / Updated on September 03, 2011 17:17