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Identification
NameLorazepam
Accession NumberDB00186  (APRD00116)
TypeSmall Molecule
GroupsApproved
DescriptionA benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent. [PubChem]
Structure
Thumb
Synonyms
(±)-Lorazepam
Ativan
Lormetazepam
Methyllorazepam
N-Methyllorazepam
O-Chlorooxazepam
O-Chloroxazepam
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ativantablet1 mg/1oralRx Pak Division Of Mc Kesson Corporation2013-05-01Not applicableUs
Ativantablet.5 mg/1oralValeant Pharmaceuticals North America LLC2013-05-01Not applicableUs
Ativantablet1 mg/1oralSTAT Rx USA LLC2010-03-16Not applicableUs
Ativantablet0.5 mgsublingualPfizer Canada Inc1995-12-31Not applicableCanada
Ativantablet2 mgsublingualPfizer Canada Inc1994-12-31Not applicableCanada
Ativaninjection2 mg/mLintramuscular; intravenousWest Ward Pharmaceutical Corp.1980-07-25Not applicableUs
Ativantablet1 mg/1oralCardinal Health2010-03-16Not applicableUs
Ativantablet1 mg/1oralValeant Pharmaceuticals North America LLC2013-05-01Not applicableUs
Ativantablet.5 mg/1oralSTAT Rx USA LLC2010-03-16Not applicableUs
Ativantablet2 mgoralPfizer Canada Inc1994-12-31Not applicableCanada
Ativaninjection4 mg/mLintramuscular; intravenousWest Ward Pharmaceutical Corp.1980-07-25Not applicableUs
Ativantablet2 mg/1oralValeant Pharmaceuticals North America LLC2013-05-01Not applicableUs
Ativantablet1 mg/1oralA S Medication Solutions Llc2013-05-01Not applicableUs
Ativantablet1 mgoralPfizer Canada Inc1994-12-31Not applicableCanada
Ativaninjection4 mg/mLintramuscular; intravenousWest Ward Pharmaceutical Corp.1980-07-25Not applicableUs
Ativantablet1 mgsublingualPfizer Canada Inc1994-12-31Not applicableCanada
Ativaninjection2 mg/mLintramuscular; intravenousWest Ward Pharmaceutical Corp.1980-07-25Not applicableUs
Ativantablet1 mg/1oralA S Medication Solutions Llc2010-03-16Not applicableUs
Ativantablet0.5 mgoralPfizer Canada Inc1994-12-31Not applicableCanada
Ativan Inj 4mg/mlliquid4 mgintramuscular; intravenousWyeth Ltd.1982-12-311996-09-10Canada
Ativan Injection Liq 4mg/mlsolution4 mgintramuscular; intravenousWyeth Canada1994-12-312005-01-19Canada
Ativan Subl Tab 0.5mgtablet0.5 mgsublingualWyeth Ltd.1987-12-311996-09-10Canada
Ativan Subl Tab 1mgtablet1 mgsublingualWyeth Ltd.1982-12-311996-09-10Canada
Ativan Tab 0.5mgtablet.5 mgoralWyeth Ltd.1983-12-311996-09-10Canada
Ativan Tab 1mgtablet1 mgoralWyeth Ltd.1977-12-311996-09-10Canada
Ativan Tab 2mgtablet2 mgoralWyeth Ltd.1977-12-311996-09-10Canada
Dom-lorazepamtablet.5 mgoralDominion Pharmacal2002-04-25Not applicableCanada
Dom-lorazepamtablet1 mgoralDominion Pharmacal2002-04-25Not applicableCanada
Dom-lorazepamtablet2 mgoralDominion Pharmacal2002-04-25Not applicableCanada
Lorazepaminjection2 mg/mLintramuscular; intravenousWest Ward Pharmaceutical Corp.1980-07-25Not applicableUs
Lorazepamtablet1.0 mgoralSanis Health Inc2010-06-15Not applicableCanada
Lorazepaminjection2 mg/mLintramuscular; intravenousWest Ward Pharmaceutical Corp.1980-07-25Not applicableUs
Lorazepaminjection2 mg/mLintramuscularREMEDYREPACK INC.2016-02-05Not applicableUs
Lorazepamtablet1 mgoralSivem Pharmaceuticals Ulc2015-03-12Not applicableCanada
Lorazepaminjection4 mg/mLintramuscular; intravenousWest Ward Pharmaceutical Corp.1980-07-25Not applicableUs
Lorazepaminjection, solution2 mg/mLintramuscular; intravenousBaxter Healthcare Corporation2005-09-232015-12-29Us
Lorazepamtablet2.0 mgoralSanis Health Inc2010-06-15Not applicableCanada
Lorazepaminjection4 mg/mLintramuscular; intravenousWest Ward Pharmaceutical Corp.1980-07-25Not applicableUs
Lorazepamtablet2 mgoralSivem Pharmaceuticals Ulc2015-03-12Not applicableCanada
Lorazepaminjection2 mg/mLintramuscularREMEDYREPACK INC.2015-11-14Not applicableUs
Lorazepaminjection2 mg/mLintramuscular; intravenousWest Ward Pharmaceutical Corp.1980-07-25Not applicableUs
Lorazepaminjection, solution4 mg/mLintramuscular; intravenousBaxter Healthcare Corporation2005-09-232015-12-29Us
Lorazepamtablet0.5 mgoralSivem Pharmaceuticals UlcNot applicableNot applicableCanada
Lorazepaminjection2 mg/mLintramuscular; intravenousWest Ward Pharmaceutical Corp.1980-07-25Not applicableUs
Lorazepaminjection2 mg/mLintramuscular; intravenousTYA Pharmaceuticals1980-07-25Not applicableUs
Lorazepaminjection4 mg/mLintramuscular; intravenousWest Ward Pharmaceutical Corp.1980-07-25Not applicableUs
Lorazepamtablet0.5 mgoralSanis Health Inc2010-06-15Not applicableCanada
Lorazepaminjection4 mg/mLintramuscular; intravenousWest Ward Pharmaceutical Corp.1980-07-25Not applicableUs
Lorazepam Injection USPsolution4 mgintramuscular; intravenousHospira Healthcare Corporation2014-06-10Not applicableCanada
Lorazepam Injection USPliquid4 mgintramuscular; intravenousSandoz Canada Incorporated2001-06-06Not applicableCanada
Lorazepam Injection USPsolution2 mgintramuscular; intravenousSandoz Canada Incorporated2015-11-12Not applicableCanada
Ntp-lorazepamtablet1.0 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-lorazepamtablet2.0 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-lorazepamtablet0.5 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Nu-loraz Tab 0.5mgtablet.5 mgoralNu Pharm Inc1990-12-312012-09-04Canada
Nu-loraz Tab 1mgtablet1 mgoralNu Pharm Inc1990-12-312012-09-04Canada
Nu-loraz Tab 2mgtablet2 mgoralNu Pharm Inc1990-12-312012-09-04Canada
PHL-lorazepamtablet0.5 mgoralPharmel Inc2007-07-30Not applicableCanada
PHL-lorazepamtablet1 mgoralPharmel Inc2007-07-30Not applicableCanada
PHL-lorazepamtablet2 mgoralPharmel Inc2007-07-30Not applicableCanada
PMS-lorazepam Tab 0.5mgtablet0.5 mgoralPharmascience Inc1988-12-31Not applicableCanada
PMS-lorazepam Tab 1mgtablet1 mgoralPharmascience Inc1988-12-31Not applicableCanada
PMS-lorazepam Tab 2mgtablet2 mgoralPharmascience Inc1988-12-31Not applicableCanada
Pro-lorazepam Tab 0.5mgtablet0.5 mgoralPro Doc Limitee1986-12-31Not applicableCanada
Pro-lorazepam Tab 1.0mgtablet1 mgoralPro Doc Limitee1986-12-31Not applicableCanada
Pro-lorazepam Tab 2mgtablet2 mgoralPro Doc Limitee1986-12-31Not applicableCanada
Riva-lorazepam 0.5 Mg Tabletstablet0.5 mgoralLaboratoire Riva Inc1999-08-262003-07-28Canada
Riva-lorazepam 1 Mg Tabletstablet1 mgoralLaboratoire Riva Inc1999-08-262003-07-28Canada
Riva-lorazepam 2mg Tabletstablet2 mgoralLaboratoire Riva Inc1999-08-262003-07-28Canada
Teva-lorazepamtablet1 mgoralTeva Canada Limited1985-12-31Not applicableCanada
Teva-lorazepamtablet2 mgoralTeva Canada Limited1985-12-31Not applicableCanada
Teva-lorazepamtablet0.5 mgoralTeva Canada Limited1987-12-31Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-lorazepam Sublingualtablet0.5 mgsublingualApotex Inc2013-10-16Not applicableCanada
Apo-lorazepam Sublingualtablet1 mgsublingualApotex Inc2013-10-16Not applicableCanada
Apo-lorazepam Sublingualtablet2 mgsublingualApotex Inc2013-10-16Not applicableCanada
Apo-lorazepam Tab 0.5mgtablet0.5 mgoralApotex Inc1985-12-31Not applicableCanada
Apo-lorazepam Tab 1mgtablet1 mgoralApotex Inc1985-12-31Not applicableCanada
Apo-lorazepam Tab 2mgtablet2 mgoralApotex Inc1985-12-31Not applicableCanada
Lorazepamtablet1 mg/1oralRebel Distributors Corp2007-01-04Not applicableUs
Lorazepamtablet1 mg/1oralKAISER FOUNDATION HOSPITALS2014-11-07Not applicableUs
Lorazepamtablet1 mg/1oralUnit Dose Services1991-10-31Not applicableUs
Lorazepamtablet1 mg/1oralA S Medication Solutions Llc1991-10-31Not applicableUs
Lorazepamtablet.5 mg/1oralCardinal Health2010-12-17Not applicableUs
Lorazepamtablet1 mg/1oralProficient Rx LP2007-01-04Not applicableUs
Lorazepamtablet.5 mg/1oralPreferred Pharmaceuticals Inc.2015-08-27Not applicableUs
Lorazepamtablet1 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2011-07-01Not applicableUs
Lorazepamtablet2 mg/1oralAmerican Health Packaging2013-06-192015-12-29Us
Lorazepamtablet1 mg/1oralContract Pharmacy Services Pa2011-03-29Not applicableUs
Lorazepamsolution, concentrate2 mg/mLoralPaddock Laboratories, LLC2009-04-01Not applicableUs
Lorazepamtablet1 mg/1oralUpsher Smith Laboratories, Inc.2007-01-04Not applicableUs
Lorazepamtablet.5 mg/1oralRebel Distributors Corp1988-04-15Not applicableUs
Lorazepamtablet1 mg/1oralBlenheim Pharmacal, Inc.2012-09-04Not applicableUs
Lorazepamtablet1 mg/1oralLake Erie Medical DBA Quality Care Products LLC2007-01-04Not applicableUs
Lorazepamsolution, concentrate2 mg/mLoralRoxane Laboratories, Inc1991-06-28Not applicableUs
Lorazepamtablet1 mg/1oralA S Medication Solutions Llc1991-10-31Not applicableUs
Lorazepamtablet2 mg/1oralREMEDYREPACK INC.2012-08-20Not applicableUs
Lorazepamtablet.5 mg/1oralCardinal Health2006-05-10Not applicableUs
Lorazepamtablet2 mg/1oralPd Rx Pharmaceuticals, Inc.1991-10-31Not applicableUs
Lorazepamtablet.5 mg/1oralAphena Pharma Solutions Tennessee, Llc2013-03-05Not applicableUs
Lorazepamtablet.5 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation1999-07-28Not applicableUs
Lorazepamtablet2 mg/1oralMc Kesson Contract Packaging2012-10-18Not applicableUs
Lorazepamtablet.5 mg/1oralRx Pak Division Of Mc Kesson Corporation2009-10-09Not applicableUs
Lorazepamtablet.5 mg/1oralDirectrx2016-02-18Not applicableUs
Lorazepamtablet2 mg/1oralMylan Pharmaceuticals Inc.2006-12-27Not applicableUs
Lorazepamtablet.5 mg/1oralSandoz Inc2007-01-03Not applicableUs
Lorazepamtablet.5 mg/1oralQualitest Pharmaceuticals2006-05-10Not applicableUs
Lorazepamtablet2 mg/1oralMajor Pharmaceuticals2010-03-24Not applicableUs
Lorazepamtablet1 mg/1oralAidarex Pharmaceuticals LLC2007-10-01Not applicableUs
Lorazepamtablet.5 mg/1oralPd Rx Pharmaceuticals, Inc.1991-10-31Not applicableUs
Lorazepamtablet1 mg/1oralActavis Elizabeth LLC2007-01-04Not applicableUs
Lorazepamtablet.5 mg/1oralMylan Institutional Inc.2004-03-15Not applicableUs
Lorazepamtablet2 mg/1oralPhysicians Total Care, Inc.1995-12-20Not applicableUs
Lorazepamtablet.5 mg/1oralCardinal Health2010-03-24Not applicableUs
Lorazepamtablet2 mg/1oralRanbaxy Pharmaceuticals Inc.2001-12-11Not applicableUs
Lorazepamtablet1 mg/1oralPreferred Pharmaceuticals, Inc.2015-04-16Not applicableUs
Lorazepamtablet2 mg/1oralExcellium Pharmaceutical Inc.2007-10-01Not applicableUs
Lorazepamtablet.5 mg/1oralRed Pharm Inc.2010-05-18Not applicableUs
Lorazepaminjection, solution4 mg/mLintramuscular; intravenousHospira, Inc.1994-05-27Not applicableUs
Lorazepamtablet1 mg/1oralSandoz Inc2007-01-04Not applicableUs
Lorazepamtablet.5 mg/1oralSTAT Rx USA LLC1991-10-31Not applicableUs
Lorazepamtablet1 mg/1oralRebel Distributors Corp2009-10-09Not applicableUs
Lorazepamliquid2 mg/mLoralPharmaceutical Associates, Inc.2010-11-01Not applicableUs
Lorazepamtablet.5 mg/1oralA S Medication Solutions Llc1991-10-31Not applicableUs
Lorazepamtablet2 mg/1oralREMEDYREPACK INC.2014-04-18Not applicableUs
Lorazepamtablet1 mg/1oralCardinal Health2007-01-04Not applicableUs
Lorazepamtablet1 mg/1oralDIRECT RX2014-01-01Not applicableUs
Lorazepamtablet1 mg/1oralAmerican Health Packaging2014-04-01Not applicableUs
Lorazepamtablet1 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2010-09-01Not applicableUs
Lorazepamtablet2 mg/1oralAmerican Health Packaging2008-05-012015-12-29Us
Lorazepamtablet.5 mg/1oralDispensing Solutions, Inc.2007-01-03Not applicableUs
Lorazepamtablet2 mg/1oralUpsher Smith Laboratories, Inc.2007-01-08Not applicableUs
Lorazepamtablet1 mg/1oralRebel Distributors Corp1988-04-15Not applicableUs
Lorazepamtablet2 mg/1oralSTAT Rx USA LLC1991-10-31Not applicableUs
Lorazepamtablet1 mg/1oralKAISER FOUNDATION HOSPITALS2015-09-15Not applicableUs
Lorazepamtablet2 mg/1oralUnit Dose Services2007-01-08Not applicableUs
Lorazepamtablet2 mg/1oralA S Medication Solutions Llc1991-10-31Not applicableUs
Lorazepamtablet1 mg/1oralCardinal Health2010-12-17Not applicableUs
Lorazepamtablet.5 mg/1oralProficient Rx LP2007-01-03Not applicableUs
Lorazepamtablet1 mg/1oralPreferred Pharmaceuticals, Inc.2014-02-05Not applicableUs
Lorazepamtablet2 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2011-07-01Not applicableUs
Lorazepamtablet2 mg/1oralContract Pharmacy Services Pa2011-03-29Not applicableUs
Lorazepamtablet.5 mg/1oralActavis Pharma, Inc.1991-10-31Not applicableUs
Lorazepaminjection, solution4 mg/mLintramuscular; intravenousHospira, Inc.2011-05-26Not applicableUs
Lorazepamtablet1 mg/1oralSandoz Inc2007-01-04Not applicableUs
Lorazepamtablet1 mg/1oralBlenheim Pharmacal, Inc.2011-01-12Not applicableUs
Lorazepamtablet2 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2007-01-08Not applicableUs
Lorazepamtablet.5 mg/1oralTeva Pharmaceuticals USA Inc2007-02-012016-03-11Us
Lorazepamtablet1 mg/1oralA S Medication Solutions Llc1991-10-31Not applicableUs
Lorazepamtablet.5 mg/1oralREMEDYREPACK INC.2013-05-13Not applicableUs
Lorazepamtablet1 mg/1oralCardinal Health2006-05-10Not applicableUs
Lorazepamtablet.5 mg/1oralREMEDYREPACK INC.2015-05-15Not applicableUs
Lorazepamtablet1 mg/1oralAphena Pharma Solutions Tennessee, Llc2013-03-05Not applicableUs
Lorazepamtablet1 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation1999-07-28Not applicableUs
Lorazepaminjection2 mg/mLintramuscular; intravenousInternational Medication Systems, Limited2012-12-01Not applicableUs
Lorazepamtablet1 mg/1oralRx Pak Division Of Mc Kesson Corporation2009-10-09Not applicableUs
Lorazepamtablet.5 mg/1oralAvera Mc Kennan Hospital2015-05-01Not applicableUs
Lorazepamtablet2 mg/1oralAphena Pharma Solutions Tennessee, Llc1991-10-31Not applicableUs
Lorazepamtablet1 mg/1oralQualitest Pharmaceuticals2006-05-10Not applicableUs
Lorazepamtablet.5 mg/1oralMajor Pharmaceuticals2009-10-09Not applicableUs
Lorazepamtablet2 mg/1oralAidarex Pharmaceuticals LLC2007-10-01Not applicableUs
Lorazepamtablet1 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-01-31Not applicableUs
Lorazepamtablet2 mg/1oralActavis Elizabeth LLC2007-01-08Not applicableUs
Lorazepamtablet1 mg/1oralNorthwind Pharmaceuticals2014-06-01Not applicableUs
Lorazepamtablet1 mg/1oralPhysicians Total Care, Inc.1993-07-23Not applicableUs
Lorazepamtablet2 mg/1oralCardinal Health2006-05-10Not applicableUs
Lorazepamtablet1 mg/1oralbryant ranch prepack2009-08-06Not applicableUs
Lorazepamtablet1 mg/1oralLife Line Home Care Services, Inc.1991-10-31Not applicableUs
Lorazepamtablet2 mg/1oralTYA Pharmaceuticals1991-10-31Not applicableUs
Lorazepamtablet2 mg/1oralAmerican Health Packaging2014-04-01Not applicableUs
Lorazepamtablet2 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2010-09-01Not applicableUs
Lorazepamtablet.5 mg/1oralAmerican Health Packaging2013-06-192015-12-29Us
Lorazepamtablet2 mg/1oralDispensing Solutions, Inc.2007-01-08Not applicableUs
Lorazepaminjection, solution2 mg/mLintramuscular; intravenousHospira, Inc.1994-05-27Not applicableUs
Lorazepamtablet2 mg/1oralSandoz Inc2007-01-08Not applicableUs
Lorazepamtablet1 mg/1oralSTAT Rx USA LLC1991-10-31Not applicableUs
Lorazepamtablet2 mg/1oralRebel Distributors Corp2009-10-09Not applicableUs
Lorazepamtablet.5 mg/1oralKAISER FOUNDATION HOSPITALS2013-03-11Not applicableUs
Lorazepamconcentrate2 mg/mLoralHi Tech Pharmacal Co., Inc.2012-01-30Not applicableUs
Lorazepamtablet.5 mg/1oralREMEDYREPACK INC.2014-05-07Not applicableUs
Lorazepamtablet.5 mg/1oralCardinal Health2007-01-03Not applicableUs
Lorazepamtablet.5 mg/1oralProficient Rx LP2006-12-27Not applicableUs
Lorazepamtablet1 mg/1oralActavis Pharma, Inc.1991-10-31Not applicableUs
Lorazepamtablet.5 mg/1oralMajor Pharmaceuticals2010-03-24Not applicableUs
Lorazepamtablet2 mg/1oralRebel Distributors Corp1988-04-15Not applicableUs
Lorazepamtablet1 mg/1oralSTAT Rx USA LLC1991-10-31Not applicableUs
Lorazepamtablet.5 mg/1oralKAISER FOUNDATION HOSPITALS2015-11-23Not applicableUs
Lorazepamtablet1 mg/1oralMylan Institutional Inc.2006-12-29Not applicableUs
Lorazepamtablet.5 mg/1oralA S Medication Solutions Llc1991-10-31Not applicableUs
Lorazepamtablet2 mg/1oralCardinal Health2010-12-17Not applicableUs
Lorazepamtablet.5 mg/1oralRanbaxy Pharmaceuticals Inc.2001-12-11Not applicableUs
Lorazepamtablet1 mg/1oralPreferred Pharmaceuticals, Inc2012-03-29Not applicableUs
Lorazepamtablet.5 mg/1oralExcellium Pharmaceutical Inc.2007-10-01Not applicableUs
Lorazepamtablet1 mg/1oralRed Pharm Drug Inc.1988-04-15Not applicableUs
Lorazepaminjection, solution2 mg/mLintramuscular; intravenousHospira, Inc.2011-04-25Not applicableUs
Lorazepamtablet2 mg/1oralSandoz Inc2007-01-08Not applicableUs
Lorazepamtablet1 mg/1oralBlenheim Pharmacal, Inc.2013-11-18Not applicableUs
Lorazepamtablet1 mg/1oralLake Erie Medical DBA Quality Care Products LLC2013-03-05Not applicableUs
Lorazepamtablet1 mg/1oralTeva Pharmaceuticals USA Inc2007-02-012016-03-11Us
Lorazepamtablet1 mg/1oralA S Medication Solutions Llc2006-05-10Not applicableUs
Lorazepamtablet2 mg/1oralREMEDYREPACK INC.2013-05-08Not applicableUs
Lorazepamtablet1 mg/1oralCardinal Health2010-09-01Not applicableUs
Lorazepamtablet1 mg/1oralREMEDYREPACK INC.2015-06-23Not applicableUs
Lorazepamtablet2 mg/1oralAphena Pharma Solutions Tennessee, Llc2013-03-05Not applicableUs
Lorazepamtablet2 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation1999-07-28Not applicableUs
Lorazepamtablet.5 mg/1oralAmerican Health Packaging2008-05-012015-12-29Us
Lorazepamtablet2 mg/1oralRx Pak Division Of Mc Kesson Corporation2009-10-09Not applicableUs
Lorazepamtablet1 mg/1oralREMEDYREPACK INC.2016-03-04Not applicableUs
Lorazepamtablet.5 mg/1oralbryant ranch prepack1991-10-31Not applicableUs
Lorazepamtablet.5 mg/1oralMc Kesson Contract Packaging2012-08-28Not applicableUs
Lorazepamtablet.5 mg/1oralTYA Pharmaceuticals2001-12-11Not applicableUs
Lorazepamtablet.5 mg/1oralAphena Pharma Solutions Tennessee, Llc1991-10-31Not applicableUs
Lorazepamtablet2 mg/1oralQualitest Pharmaceuticals2006-05-10Not applicableUs
Lorazepamtablet1 mg/1oralMajor Pharmaceuticals2009-10-09Not applicableUs
Lorazepamtablet.5 mg/1oralAidarex Pharmaceuticals LLC2007-10-01Not applicableUs
Lorazepamtablet2 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-01-31Not applicableUs
Lorazepamtablet.5 mg/1oralMylan Pharmaceuticals Inc.2006-12-27Not applicableUs
Lorazepamtablet1 mg/1oralREMEDYREPACK INC.2013-02-25Not applicableUs
Lorazepamtablet.5 mg/1oralPhysicians Total Care, Inc.1993-06-29Not applicableUs
Lorazepamtablet.5 mg/1oralPd Rx Pharmaceuticals, Inc.1991-10-31Not applicableUs
Lorazepamtablet1 mg/1oralCardinal Health2007-01-04Not applicableUs
Lorazepamtablet1 mg/1oralProficient Rx LP2006-12-27Not applicableUs
Lorazepamtablet1 mg/1oralPreferred Pharmaceuticals, Inc.2013-08-27Not applicableUs
Lorazepamtablet.5 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2011-07-01Not applicableUs
Lorazepamtablet1 mg/1oralAmerican Health Packaging2013-06-192015-12-29Us
Lorazepamtablet.5 mg/1oralContract Pharmacy Services Pa2011-03-29Not applicableUs
Lorazepaminjection, solution4 mg/mLintramuscular; intravenousHospira, Inc.1994-05-27Not applicableUs
Lorazepamtablet.5 mg/1oralUpsher Smith Laboratories, Inc.2007-01-03Not applicableUs
Lorazepaminjection2 mg/mLintramuscularAkorn, Inc.1980-07-01Not applicableUs
Lorazepamtablet.5 mg/1oralRebel Distributors Corp2009-10-09Not applicableUs
Lorazepamtablet.5 mg/1oralKAISER FOUNDATION HOSPITALS2014-04-28Not applicableUs
Lorazepamtablet.5 mg/1oralUnit Dose Services2007-01-03Not applicableUs
Lorazepamtablet1 mg/1oralREMEDYREPACK INC.2014-05-23Not applicableUs
Lorazepamtablet2 mg/1oralActavis Pharma, Inc.1991-10-31Not applicableUs
Lorazepamtablet1 mg/1oralMajor Pharmaceuticals2010-03-24Not applicableUs
Lorazepamtablet.5 mg/1oralREMEDYREPACK INC.2013-05-21Not applicableUs
Lorazepamtablet1 mg/1oralPd Rx Pharmaceuticals, Inc.1991-10-31Not applicableUs
Lorazepamtablet.5 mg/1oralActavis Elizabeth LLC2007-01-03Not applicableUs
Lorazepamtablet2 mg/1oralMylan Institutional Inc.2006-12-28Not applicableUs
Lorazepamtablet1 mg/1oralA S Medication Solutions Llc1991-10-31Not applicableUs
Lorazepamtablet1 mg/1oralCardinal Health2010-03-24Not applicableUs
Lorazepamtablet1 mg/1oralRanbaxy Pharmaceuticals Inc.2001-12-11Not applicableUs
Lorazepamtablet.5 mg/1oralPreferred Pharmaceuticals, Inc2012-03-29Not applicableUs
Lorazepamtablet1 mg/1oralExcellium Pharmaceutical Inc.2007-10-01Not applicableUs
Lorazepamtablet1 mg/1oralRed Pharm Drug Inc.1991-10-31Not applicableUs
Lorazepaminjection, solution2 mg/mLintramuscular; intravenousHospira, Inc.1994-05-27Not applicableUs
Lorazepamtablet.5 mg/1oralSandoz Inc2007-01-03Not applicableUs
Lorazepamtablet1 mg/1oralApotheca, Inc2001-12-11Not applicableUs
Lorazepamtablet1 mg/1oralLake Erie Medical DBA Quality Care Products LLC2001-12-11Not applicableUs
Lorazepamtablet2 mg/1oralTeva Pharmaceuticals USA Inc2007-02-012016-03-11Us
Lorazepamtablet1 mg/1oralA S Medication Solutions Llc2006-05-10Not applicableUs
Lorazepamtablet2 mg/1oralREMEDYREPACK INC.2014-03-11Not applicableUs
Lorazepamtablet.5 mg/1oralCardinal Health2007-01-03Not applicableUs
Lorazepamtablet.5 mg/1oralREMEDYREPACK INC.2015-10-08Not applicableUs
Lorazepamtablet.5 mg/1oralAmerican Health Packaging2014-04-01Not applicableUs
Lorazepamtablet.5 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2010-09-01Not applicableUs
Lorazepamtablet1 mg/1oralAmerican Health Packaging2008-05-012015-12-29Us
Lorazepamtablet1 mg/1oralDispensing Solutions, Inc.2007-01-04Not applicableUs
Lorazepaminjection, solution2 mg/mLintramuscular; intravenousPhysicians Total Care, Inc.2007-01-10Not applicableUs
Lorazepamtablet1 mg/1oralPd Rx Pharmaceuticals, Inc.1991-10-31Not applicableUs
Lorazepamtablet2 mg/1oralbryant ranch prepack1991-10-31Not applicableUs
Lorazepamtablet1 mg/1oralMc Kesson Contract Packaging2012-09-07Not applicableUs
Lorazepamtablet1 mg/1oralTYA Pharmaceuticals2001-12-11Not applicableUs
Lorazepamconcentrate2 mg/mLoralAmneal Pharmaceuticals of New York, LLC2010-02-01Not applicableUs
Lorazepamtablet1 mg/1oralAphena Pharma Solutions Tennessee, Llc1991-10-31Not applicableUs
Lorazepamtablet.5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-12-27Not applicableUs
Lorazepamtablet2 mg/1oralMajor Pharmaceuticals2009-10-09Not applicableUs
Lorazepamtablet2 mg/1oralRx Change Co.2014-11-12Not applicableUs
Lorazepamtablet.5 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-11-17Not applicableUs
Lorazepamtablet1 mg/1oralMylan Pharmaceuticals Inc.2006-12-27Not applicableUs
Lorazepamtablet.5 mg/1oralREMEDYREPACK INC.2012-08-20Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
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SaltsNot Available
Categories
UNIIO26FZP769L
CAS number846-49-1
WeightAverage: 321.158
Monoisotopic: 320.011932988
Chemical FormulaC15H10Cl2N2O2
InChI KeyInChIKey=DIWRORZWFLOCLC-UHFFFAOYSA-N
InChI
InChI=1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)
IUPAC Name
7-chloro-5-(2-chlorophenyl)-3-hydroxy-2,3-dihydro-1H-1,4-benzodiazepin-2-one
SMILES
OC1N=C(C2=CC=CC=C2Cl)C2=C(NC1=O)C=CC(Cl)=C2
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as 1,4-benzodiazepines. These are organic compounds containing a benzene ring fused to a 1,4-azepine.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzodiazepines
Sub Class1,4-benzodiazepines
Direct Parent1,4-benzodiazepines
Alternative Parents
Substituents
  • 1,4-benzodiazepine
  • Halobenzene
  • Chlorobenzene
  • Benzenoid
  • Monocyclic benzene moiety
  • Aryl halide
  • Aryl chloride
  • Secondary carboxylic acid amide
  • Lactam
  • Ketimine
  • Carboxamide group
  • Azacycle
  • Organic 1,3-dipolar compound
  • Propargyl-type 1,3-dipolar organic compound
  • Carboxylic acid derivative
  • Carboxylic acid amide
  • Alkanolamine
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Imine
  • Carbonyl group
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor the management of anxiety disorders, and for treatment of status epilepticus.
PharmacodynamicsLorazepam, a benzodiazepine not transformed to active metabolites, is used to treat anxiety, status epilepticus, and for sedation induction and anterograde amnesia.
Mechanism of actionLorazepam binds to an allosteric site on GABA-A receptors, which are pentameric ionotropic receptors in the CNS. Binding potentiates the effects of the inhibitory neurotransmitter GABA, which upon binding opens the chloride channel in the receptor, allowing chloride influx and causing hyperpolerization of the neuron.
Related Articles
AbsorptionReadily absorbed with an absolute bioavailability of 90% when given orally. When intramuscularly administered, lorazepam is completely and rapidly absorbed. It achieves max serum concentration in 3 hours. The max serum concentration of a 4 mg dose is 48 ng/mL.
Volume of distribution

1.3 L/kg. Unbound lorazepam can cross the blood-brain-barrier via passive diffusion.

Protein binding91±2% bound to plasma proteins when given parenterally. When given orally, it is 85% bound to plasma proteins.
Metabolism

Lorazepam is hepatically metabolized and is extensively conjugated to the 3-0-phenolic glucuronide. This is an inactive metabolite and is eliminated mainly by the kidneys.

SubstrateEnzymesProduct
Lorazepam
Not Available
Lorazepam glucuronideDetails
Route of eliminationWhen a single 2 mg oral dose is give to healthy subjects, 88±4% of the administered dose was recovered in urine and 7±2% was recovered in feces. The percent of administered dose recovered in urine as lorazepam glucuronide was 74±4%. Only 0.3% of the dose was recovered as unchanged lorazepam, and the remainder of the radioactivity represented minor metabolites.
Half lifeParenteral administration = 14±5 hours; Oral administration = 2 hours.
Clearance

Total clearance, parenteral administration = 1.1±0.4 mL/min/kg.

ToxicityThe most important clinical adverse event caused by lorazepam is respiratory depression. LD50, mouse, oral = 1850 mg/kg.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9826
Blood Brain Barrier+0.9641
Caco-2 permeable+0.8867
P-glycoprotein substrateSubstrate0.517
P-glycoprotein inhibitor INon-inhibitor0.8866
P-glycoprotein inhibitor IINon-inhibitor0.9167
Renal organic cation transporterNon-inhibitor0.8812
CYP450 2C9 substrateNon-substrate0.7692
CYP450 2D6 substrateNon-substrate0.8685
CYP450 3A4 substrateSubstrate0.5631
CYP450 1A2 substrateInhibitor0.8262
CYP450 2C9 inhibitorNon-inhibitor0.5063
CYP450 2D6 inhibitorNon-inhibitor0.8445
CYP450 2C19 inhibitorInhibitor0.5065
CYP450 3A4 inhibitorNon-inhibitor0.6563
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.6407
Ames testNon AMES toxic0.9133
CarcinogenicityNon-carcinogens0.7711
BiodegradationNot ready biodegradable1.0
Rat acute toxicity1.8229 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.999
hERG inhibition (predictor II)Non-inhibitor0.8734
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Amneal pharmaceuticals
  • Paddock laboratories inc
  • Pharmaceutical assoc inc
  • Roxane laboratories inc
  • Baxter healthcare corp anesthesia critical care
  • Akorn inc
  • Baxter healthcare corp anesthesia and critical care
  • Bedford laboratories div ben venue laboratories inc
  • Dava pharmaceuticals inc
  • Hospira inc
  • International medication systems ltd
  • Marsam pharmaceuticals llc
  • Taylor pharmaceuticals
  • Watson laboratories inc
  • Bedford laboratories
  • Biovail laboratories inc
  • Quantum pharmics ltd
  • Actavis elizabeth llc
  • American therapeutics inc
  • Excellium pharmaceutical inc
  • Halsey drug co inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Mutual pharmaceutical co inc
  • Mylan pharmaceuticals inc
  • Par pharmaceutical inc
  • Ranbaxy laboratories ltd
  • Sandoz inc
  • Superpharm corp
  • Usl pharma inc
  • Vintage pharmaceuticals inc
  • Warner chilcott div warner lambert co
Packagers
Dosage forms
FormRouteStrength
Injectionintramuscular; intravenous2 mg/mL
Injectionintramuscular; intravenous4 mg/mL
Tabletoral0.5 mg
Tabletoral1 mg
Tabletoral2 mg
Tabletsublingual0.5 mg
Tabletsublingual1 mg
Tabletsublingual2 mg
Tabletoral.5 mg
Concentrateoral2 mg/mL
Injectionintramuscular2 mg/mL
Injection, solutionintramuscular; intravenous2 mg/mL
Injection, solutionintramuscular; intravenous4 mg/mL
Liquidoral2 mg/mL
Solution, concentrateoral2 mg/mL
Tabletoral.5 mg/1
Tabletoral1 mg/1
Tabletoral1.0 mg
Tabletoral2 mg/1
Tabletoral2.0 mg
Liquidintramuscular; intravenous4 mg
Solutionintramuscular; intravenous2 mg
Solutionintramuscular; intravenous4 mg
Prices
Unit descriptionCostUnit
LORazepam Intensol 2 mg/ml Concentrate 30ml Bottle44.99USD bottle
Lorazepam powder20.81USD g
Lorazepam 4 mg/ml vial9.59USD ml
Lorazepam 2 mg/ml vial2.5USD ml
Ativan 2 mg tablet2.3USD tablet
Ativan 4 mg/ml vial2.16USD ml
Ativan 1 mg tablet1.96USD tablet
Lorazepam intensol 2 mg/ml1.6USD ml
Lorazepam-ns 60 mg/60 ml bag1.53USD ml
Ativan 0.5 mg tablet1.37USD tablet
Lorazepam-d5w 100 mg/100 ml1.16USD ml
Lorazepam-ns 100 mg/100 ml bag1.16USD ml
Lorazepam 2 mg tablet1.01USD tablet
Ativan 2 mg/ml vial0.9USD ml
Lorazepam 1 mg tablet0.69USD tablet
Lorazepam 0.5 mg tablet0.55USD tablet
Ativan 2 mg Sublingual Tablet0.24USD tablet
Ativan 1 mg Sublingual Tablet0.15USD tablet
Ativan 0.5 mg Sublingual Tablet0.12USD tablet
Apo-Lorazepam 2 mg Tablet0.07USD tablet
Novo-Lorazem 2 mg Tablet0.07USD tablet
Pms-Lorazepam 2 mg Tablet0.07USD tablet
Apo-Lorazepam 1 mg Tablet0.05USD tablet
Novo-Lorazem 1 mg Tablet0.05USD tablet
Pms-Lorazepam 1 mg Tablet0.05USD tablet
Apo-Lorazepam 0.5 mg Tablet0.04USD tablet
Novo-Lorazem 0.5 mg Tablet0.04USD tablet
Pms-Lorazepam 0.5 mg Tablet0.04USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point192-194British Patent 1,022,642.
water solubility80 mg/LMERCK INDEX (1996)
logP2.39HANSCH,C ET AL. (1995)
logS-3.6ADME Research, USCD
pKa13MERCK INDEX (1996); pK1
Predicted Properties
PropertyValueSource
Water Solubility0.0176 mg/mLALOGPS
logP2.98ALOGPS
logP3.53ChemAxon
logS-4.3ALOGPS
pKa (Strongest Acidic)10.61ChemAxon
pKa (Strongest Basic)-2.2ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area61.69 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity82.7 m3·mol-1ChemAxon
Polarizability30.33 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-002r-4981000000-a567f7beb26ee18d061cView in MoNA
References
Synthesis Reference

Igor Lifshitz, “Process for preparing pure crystalline lorazepam.” U.S. Patent US20010039340, issued November 08, 2001.

US20010039340
General References
  1. Kemper N, Poser W, Poser S: [Benzodiazepine dependence: addiction potential of the benzodiazepines is greater than previously assumed (author's transl)]. Dtsch Med Wochenschr. 1980 Dec 5;105(49):1707-12. [PubMed:7439058 ]
  2. Lader M: Short-term versus long-term benzodiazepine therapy. Curr Med Res Opin. 1984;8 Suppl 4:120-6. [PubMed:6144459 ]
  3. Maltais F, Laberge F, Laviolette M: A randomized, double-blind, placebo-controlled study of lorazepam as premedication for bronchoscopy. Chest. 1996 May;109(5):1195-8. [PubMed:8625666 ]
  4. Heisterkamp DV, Cohen PJ: The effect of intravenous premedication with lorazepam (ativan), pentobarbitone or diazepam on recall. Br J Anaesth. 1975 Jan;47(1):79-81. [PubMed:238548 ]
  5. Milligan DW, Howard MR, Judd A: Premedication with lorazepam before bone marrow biopsy. J Clin Pathol. 1987 Jun;40(6):696-8. [PubMed:3611398 ]
External Links
ATC CodesN05BA56N05BA06N05CD06
AHFS Codes
  • 28:24.08
PDB EntriesNot Available
FDA labelDownload (540 KB)
MSDSDownload (81.8 KB)
Interactions
Drug Interactions
Drug
7-NitroindazoleThe risk or severity of adverse effects can be increased when Lorazepam is combined with 7-Nitroindazole.
AcepromazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Acepromazine.
AceprometazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Aceprometazine.
adipiplonThe risk or severity of adverse effects can be increased when Lorazepam is combined with adipiplon.
AgomelatineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Agomelatine.
AlfaxaloneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Alfaxalone.
AlfentanilThe risk or severity of adverse effects can be increased when Lorazepam is combined with Alfentanil.
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Alphacetylmethadol.
AlprazolamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Alprazolam.
AminophyllineThe therapeutic efficacy of Lorazepam can be decreased when used in combination with Aminophylline.
AmisulprideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Amisulpride.
AmitriptylineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Amitriptyline.
AmobarbitalThe risk or severity of adverse effects can be increased when Lorazepam is combined with Amobarbital.
AmoxapineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Amoxapine.
AmperozideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Amperozide.
AripiprazoleThe risk or severity of adverse effects can be increased when Lorazepam is combined with Aripiprazole.
ArticaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Articaine.
AsenapineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Asenapine.
AzaperoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Azaperone.
AzelastineLorazepam may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Lorazepam.
BaclofenThe risk or severity of adverse effects can be increased when Lorazepam is combined with Baclofen.
BarbitalThe risk or severity of adverse effects can be increased when Lorazepam is combined with Barbital.
BenzocaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Benzocaine.
Benzyl alcoholThe risk or severity of adverse effects can be increased when Lorazepam is combined with Benzyl alcohol.
BrexpiprazoleThe risk or severity of adverse effects can be increased when Lorazepam is combined with Brexpiprazole.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.
BrimonidineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Brimonidine.
BromazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Bromazepam.
BrompheniramineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Brompheniramine.
BrotizolamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Brotizolam.
BupivacaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Bupivacaine.
BuprenorphineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Buprenorphine.
BuspironeThe risk or severity of adverse effects can be increased when Lorazepam is combined with Buspirone.
ButabarbitalThe risk or severity of adverse effects can be increased when Lorazepam is combined with Butabarbital.
ButacaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Butacaine.
ButalbitalThe risk or severity of adverse effects can be increased when Lorazepam is combined with Butalbital.
ButambenThe risk or severity of adverse effects can be increased when Lorazepam is combined with Butamben.
ButethalThe risk or severity of adverse effects can be increased when Lorazepam is combined with Butethal.
ButorphanolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Butorphanol.
CarbamazepineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Carbamazepine.
CarbinoxamineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Carbinoxamine.
CarfentanilThe risk or severity of adverse effects can be increased when Lorazepam is combined with Carfentanil.
CarisoprodolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Carisoprodol.
CetirizineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Cetirizine.
Chloral hydrateThe risk or severity of adverse effects can be increased when Lorazepam is combined with Chloral hydrate.
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Chlordiazepoxide.
ChlormezanoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Chlormezanone.
ChloroprocaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Chloroprocaine.
ChlorphenamineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Chlorphenamine.
ChlorpromazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Chlorpromazine.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Chlorprothixene.
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Chlorzoxazone.
CinchocaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Cinchocaine.
CitalopramThe risk or severity of adverse effects can be increased when Lorazepam is combined with Citalopram.
ClemastineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Clemastine.
ClidiniumThe risk or severity of adverse effects can be increased when Lorazepam is combined with Clidinium.
ClobazamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Clobazam.
clomethiazoleThe risk or severity of adverse effects can be increased when Lorazepam is combined with clomethiazole.
ClomipramineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Clomipramine.
ClonazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Clonazepam.
ClonidineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Clonidine.
ClorazepateThe risk or severity of adverse effects can be increased when Lorazepam is combined with Clorazepate.
ClozapineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Clozapine.
CocaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Cocaine.
CodeineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Codeine.
CyclizineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Cyclizine.
CyclobenzaprineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Cyclobenzaprine.
CyproheptadineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Cyproheptadine.
DantroleneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Dantrolene.
DapiprazoleThe risk or severity of adverse effects can be increased when Lorazepam is combined with Dapiprazole.
DapoxetineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Dapoxetine.
deramciclaneThe risk or severity of adverse effects can be increased when Lorazepam is combined with deramciclane.
DesfluraneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Desflurane.
DesipramineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Desipramine.
DesloratadineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Desloratadine.
DetomidineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Detomidine.
DexbrompheniramineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Dexbrompheniramine.
DexmedetomidineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Dexmedetomidine.
DextromoramideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Dextromoramide.
DextropropoxypheneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Dextropropoxyphene.
DezocineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Dezocine.
DiazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Diazepam.
DifenoxinThe risk or severity of adverse effects can be increased when Lorazepam is combined with Difenoxin.
DihydrocodeineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Dihydrocodeine.
DihydroetorphineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Dihydroetorphine.
DihydromorphineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Dihydromorphine.
DimenhydrinateThe risk or severity of adverse effects can be increased when Lorazepam is combined with Dimenhydrinate.
DiphenhydramineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Diphenhydramine.
DiphenoxylateThe risk or severity of adverse effects can be increased when Lorazepam is combined with Diphenoxylate.
DoramectinThe risk or severity of adverse effects can be increased when Lorazepam is combined with Doramectin.
DoxepinThe risk or severity of adverse effects can be increased when Lorazepam is combined with Doxepin.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.
DoxylamineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Doxylamine.
DPDPEThe risk or severity of adverse effects can be increased when Lorazepam is combined with DPDPE.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.
DroperidolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Droperidol.
DrotebanolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Drotebanol.
DyclonineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Dyclonine.
DyphyllineThe therapeutic efficacy of Lorazepam can be decreased when used in combination with Dyphylline.
EcgonineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ecgonine.
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Lorazepam is combined with ECGONINE METHYL ESTER.
EfavirenzThe risk or severity of adverse effects can be increased when Lorazepam is combined with Efavirenz.
EnfluraneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Enflurane.
EntacaponeThe risk or severity of adverse effects can be increased when Lorazepam is combined with Entacapone.
EscitalopramThe risk or severity of adverse effects can be increased when Lorazepam is combined with Escitalopram.
EstazolamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Estazolam.
EszopicloneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Eszopiclone.
EthanolLorazepam may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Lorazepam.
EthchlorvynolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ethchlorvynol.
EthosuximideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ethosuximide.
EthotoinThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ethotoin.
Ethyl carbamateThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ethyl carbamate.
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ethyl loflazepate.
EthylmorphineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ethylmorphine.
EtidocaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Etidocaine.
EtifoxineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Etifoxine.
EtizolamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Etizolam.
EtomidateThe risk or severity of adverse effects can be increased when Lorazepam is combined with Etomidate.
EtoperidoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Etoperidone.
EtorphineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Etorphine.
EzogabineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ezogabine.
FelbamateThe risk or severity of adverse effects can be increased when Lorazepam is combined with Felbamate.
FencamfamineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Fencamfamine.
FenfluramineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Fenfluramine.
FentanylThe risk or severity of adverse effects can be increased when Lorazepam is combined with Fentanyl.
FexofenadineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Fexofenadine.
FlibanserinThe risk or severity of adverse effects can be increased when Lorazepam is combined with Flibanserin.
FludiazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Fludiazepam.
FlunarizineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Flunarizine.
FlunitrazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Flunitrazepam.
FluoxetineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Fluoxetine.
FlupentixolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Flupentixol.
FluphenazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Fluphenazine.
FlurazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Flurazepam.
FluspirileneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Fluspirilene.
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Lorazepam is combined with Fluticasone Propionate.
FluvoxamineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Fluvoxamine.
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Lorazepam.
FosphenytoinThe risk or severity of adverse effects can be increased when Fosphenytoin is combined with Lorazepam.
FospropofolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Fospropofol.
GabapentinThe risk or severity of adverse effects can be increased when Lorazepam is combined with Gabapentin.
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Lorazepam is combined with gabapentin enacarbil.
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Lorazepam is combined with Gamma Hydroxybutyric Acid.
GlutethimideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Glutethimide.
GuanfacineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Guanfacine.
HalazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Halazepam.
HaloperidolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Haloperidol.
HalothaneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Halothane.
HeroinThe risk or severity of adverse effects can be increased when Lorazepam is combined with Heroin.
HexobarbitalThe risk or severity of adverse effects can be increased when Lorazepam is combined with Hexobarbital.
HydrocodoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Hydrocodone.
HydromorphoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Hydromorphone.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.
HydroxyzineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Hydroxyzine.
IloperidoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Iloperidone.
ImipramineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Imipramine.
IndalpineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Indalpine.
IsofluraneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Isoflurane.
KetamineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ketamine.
KetazolamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ketazolam.
KetobemidoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ketobemidone.
LamotrigineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Lamotrigine.
LevetiracetamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Levetiracetam.
LevobupivacaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Levobupivacaine.
LevocabastineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Levocabastine.
LevocetirizineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Levocetirizine.
LevodopaThe risk or severity of adverse effects can be increased when Lorazepam is combined with Levodopa.
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Lorazepam is combined with Levomethadyl Acetate.
LevomilnacipranThe risk or severity of adverse effects can be increased when Lorazepam is combined with Levomilnacipran.
LevorphanolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Levorphanol.
LidocaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Lidocaine.
LithiumThe risk or severity of adverse effects can be increased when Lorazepam is combined with Lithium.
LofentanilThe risk or severity of adverse effects can be increased when Lorazepam is combined with Lofentanil.
LoratadineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Loratadine.
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Lorazepam.
Lu AA21004The risk or severity of adverse effects can be increased when Lorazepam is combined with Lu AA21004.
LurasidoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Lurasidone.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.
Magnesium SulfateThe risk or severity of adverse effects can be increased when Lorazepam is combined with Magnesium Sulfate.
MaprotilineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Maprotiline.
MeclizineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Meclizine.
MedetomidineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Medetomidine.
MefloquineThe therapeutic efficacy of Lorazepam can be decreased when used in combination with Mefloquine.
MelatoninThe risk or severity of adverse effects can be increased when Lorazepam is combined with Melatonin.
MelperoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Melperone.
MepivacaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Mepivacaine.
MeprobamateThe risk or severity of adverse effects can be increased when Lorazepam is combined with Meprobamate.
MesoridazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Mesoridazine.
MetaxaloneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Metaxalone.
MethadoneLorazepam may increase the central nervous system depressant (CNS depressant) activities of Methadone.
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Lorazepam.
Methadyl AcetateThe risk or severity of adverse effects can be increased when Lorazepam is combined with Methadyl Acetate.
MethapyrileneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Methapyrilene.
MethaqualoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Methaqualone.
MethocarbamolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Methocarbamol.
MethohexitalThe risk or severity of adverse effects can be increased when Lorazepam is combined with Methohexital.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Methotrimeprazine.
MethoxyfluraneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Methoxyflurane.
MethsuximideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Methsuximide.
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Lorazepam is combined with Methylphenobarbital.
MetyrosineLorazepam may increase the sedative activities of Metyrosine.
MianserinThe therapeutic efficacy of Lorazepam can be decreased when used in combination with Mianserin.
MidazolamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Midazolam.
MilnacipranThe risk or severity of adverse effects can be increased when Lorazepam is combined with Milnacipran.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.
MirtazapineLorazepam may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MirtazapineThe risk or severity of adverse effects can be increased when Mirtazapine is combined with Lorazepam.
MolindoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Molindone.
MorphineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Morphine.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.
NabiloneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Nabilone.
NalbuphineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Nalbuphine.
NitrazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Nitrazepam.
Nitrous oxideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Nitrous oxide.
NormethadoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Normethadone.
NortriptylineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Nortriptyline.
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Lorazepam.
OlopatadineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Olopatadine.
OndansetronThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ondansetron.
OpiumThe risk or severity of adverse effects can be increased when Lorazepam is combined with Opium.
OrlistatThe serum concentration of Lorazepam can be decreased when it is combined with Orlistat.
OrphenadrineLorazepam may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OrphenadrineThe risk or severity of adverse effects can be increased when Orphenadrine is combined with Lorazepam.
OsanetantThe risk or severity of adverse effects can be increased when Lorazepam is combined with Osanetant.
OxazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Oxazepam.
OxprenololThe risk or severity of adverse effects can be increased when Lorazepam is combined with Oxprenolol.
OxybuprocaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Oxybuprocaine.
OxycodoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Oxycodone.
OxymorphoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Oxymorphone.
PaliperidoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Paliperidone.
ParaldehydeLorazepam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParaldehydeThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Lorazepam.
ParoxetineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Paroxetine.
PentazocineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Pentazocine.
PentobarbitalThe risk or severity of adverse effects can be increased when Lorazepam is combined with Pentobarbital.
PerampanelThe risk or severity of adverse effects can be increased when Lorazepam is combined with Perampanel.
PerospironeThe risk or severity of adverse effects can be increased when Lorazepam is combined with Perospirone.
PerphenazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Perphenazine.
PethidineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Pethidine.
PhenobarbitalThe risk or severity of adverse effects can be increased when Lorazepam is combined with Phenobarbital.
PhenoxyethanolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Phenoxyethanol.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Lorazepam.
PhenytoinThe risk or severity of adverse effects can be increased when Phenytoin is combined with Lorazepam.
PimozideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Pimozide.
PipamperoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Pipamperone.
PipotiazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Pipotiazine.
PizotifenThe risk or severity of adverse effects can be increased when Lorazepam is combined with Pizotifen.
PomalidomideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Pomalidomide.
PramipexoleLorazepam may increase the sedative activities of Pramipexole.
PramocaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Pramocaine.
PrazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Prazepam.
PregabalinThe risk or severity of adverse effects can be increased when Lorazepam is combined with Pregabalin.
PrilocaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Prilocaine.
PrimidoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Primidone.
ProbenecidThe serum concentration of Lorazepam can be increased when it is combined with Probenecid.
ProcaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Procaine.
ProchlorperazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Prochlorperazine.
PromazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Promazine.
PromethazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Promethazine.
ProparacaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Proparacaine.
PropofolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Propofol.
PropoxycaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Propoxycaine.
ProtriptylineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Protriptyline.
PSD502The risk or severity of adverse effects can be increased when Lorazepam is combined with PSD502.
QuazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Quazepam.
QuetiapineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Quetiapine.
RamelteonThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ramelteon.
RemifentanilThe risk or severity of adverse effects can be increased when Lorazepam is combined with Remifentanil.
RemoxiprideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Remoxipride.
ReserpineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Reserpine.
RisperidoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Risperidone.
RomifidineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Romifidine.
RopiniroleLorazepam may increase the sedative activities of Ropinirole.
RopivacaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ropivacaine.
RotigotineLorazepam may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Lorazepam.
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Lorazepam is combined with S-Ethylisothiourea.
ScopolamineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Scopolamine.
SecobarbitalThe risk or severity of adverse effects can be increased when Lorazepam is combined with Secobarbital.
SertindoleThe risk or severity of adverse effects can be increased when Lorazepam is combined with Sertindole.
SertralineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Sertraline.
SevofluraneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Sevoflurane.
Sodium oxybateLorazepam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Sodium oxybateThe risk or severity of adverse effects can be increased when Sodium oxybate is combined with Lorazepam.
StiripentolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Stiripentol.
SufentanilThe risk or severity of adverse effects can be increased when Lorazepam is combined with Sufentanil.
SulpirideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Sulpiride.
SuvorexantThe risk or severity of adverse effects can be increased when Lorazepam is combined with Suvorexant.
TapentadolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Tapentadol.
TasimelteonThe risk or severity of adverse effects can be increased when Lorazepam is combined with Tasimelteon.
TeduglutideThe serum concentration of Lorazepam can be increased when it is combined with Teduglutide.
TemazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Temazepam.
TetrabenazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Tetrabenazine.
TetracaineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Tetracaine.
TetrodotoxinThe risk or severity of adverse effects can be increased when Lorazepam is combined with Tetrodotoxin.
ThalidomideLorazepam may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Lorazepam.
TheophyllineThe therapeutic efficacy of Lorazepam can be decreased when used in combination with Theophylline.
ThiamylalThe risk or severity of adverse effects can be increased when Lorazepam is combined with Thiamylal.
ThiopentalThe risk or severity of adverse effects can be increased when Lorazepam is combined with Thiopental.
ThioridazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Thioridazine.
ThiothixeneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Thiothixene.
TiagabineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Tiagabine.
TiletamineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Tiletamine.
TizanidineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Tizanidine.
TolcaponeThe risk or severity of adverse effects can be increased when Lorazepam is combined with Tolcapone.
TopiramateThe risk or severity of adverse effects can be increased when Lorazepam is combined with Topiramate.
TramadolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Tramadol.
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Trans-2-Phenylcyclopropylamine.
TranylcypromineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Tranylcypromine.
TrazodoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Trazodone.
TriazolamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Triazolam.
TrifluoperazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Trifluoperazine.
TriflupromazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Triflupromazine.
TrimipramineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Trimipramine.
TriprolidineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Triprolidine.
Valproic AcidThe risk or severity of adverse effects can be increased when Lorazepam is combined with Valproic Acid.
VigabatrinThe risk or severity of adverse effects can be increased when Lorazepam is combined with Vigabatrin.
VilazodoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Vilazodone.
VortioxetineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Vortioxetine.
XylazineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Xylazine.
YohimbineThe therapeutic efficacy of Lorazepam can be decreased when used in combination with Yohimbine.
ZaleplonThe risk or severity of adverse effects can be increased when Lorazepam is combined with Zaleplon.
ZiconotideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ziconotide.
ZimelidineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Zimelidine.
ZiprasidoneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Ziprasidone.
ZolazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Zolazepam.
ZolpidemThe risk or severity of adverse effects can be increased when Lorazepam is combined with Zolpidem.
ZonisamideThe risk or severity of adverse effects can be increased when Lorazepam is combined with Zonisamide.
ZopicloneThe risk or severity of adverse effects can be increased when Lorazepam is combined with Zopiclone.
ZotepineThe risk or severity of adverse effects can be increased when Lorazepam is combined with Zotepine.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Lorazepam is combined with Zuclopenthixol.
Food Interactions
  • Avoid alcohol.
  • Avoid excessive quantities of coffee or tea (Caffeine).
  • Take with food.

Targets

Kind
Protein group
Organism
Human
Pharmacological action
yes
Actions
positive allosteric modulator
General Function:
Inhibitory extracellular ligand-gated ion channel activity
Specific Function:
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).
Components:
NameUniProt IDDetails
Gamma-aminobutyric acid receptor subunit alpha-1P14867 Details
Gamma-aminobutyric acid receptor subunit alpha-2P47869 Details
Gamma-aminobutyric acid receptor subunit alpha-3P34903 Details
Gamma-aminobutyric acid receptor subunit alpha-4P48169 Details
Gamma-aminobutyric acid receptor subunit alpha-5P31644 Details
Gamma-aminobutyric acid receptor subunit alpha-6Q16445 Details
Gamma-aminobutyric acid receptor subunit beta-1P18505 Details
Gamma-aminobutyric acid receptor subunit beta-2P47870 Details
Gamma-aminobutyric acid receptor subunit beta-3P28472 Details
Gamma-aminobutyric acid receptor subunit deltaO14764 Details
Gamma-aminobutyric acid receptor subunit epsilonP78334 Details
Gamma-aminobutyric acid receptor subunit gamma-1Q8N1C3 Details
Gamma-aminobutyric acid receptor subunit gamma-2P18507 Details
Gamma-aminobutyric acid receptor subunit gamma-3Q99928 Details
Gamma-aminobutyric acid receptor subunit piO00591 Details
Gamma-aminobutyric acid receptor subunit thetaQ9UN88 Details
References
  1. Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. doi: 10.1111/j.1600-0404.2008.01004.x. Epub 2008 Mar 31. [PubMed:18384456 ]
  2. ChEMBL Compound Report Card [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
other
General Function:
Cholesterol binding
Specific Function:
Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:24814875), but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benz...
Gene Name:
TSPO
Uniprot ID:
P30536
Molecular Weight:
18827.81 Da
References
  1. Venneti S, Lopresti BJ, Wiley CA: The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: from pathology to imaging. Prog Neurobiol. 2006 Dec;80(6):308-22. Epub 2006 Dec 6. [PubMed:17156911 ]
  2. Park CH, Carboni E, Wood PL, Gee KW: Characterization of peripheral benzodiazepine type sites in a cultured murine BV-2 microglial cell line. Glia. 1996 Jan;16(1):65-70. [PubMed:8787774 ]
  3. Uusi-Oukari M, Korpi ER: Specific alterations in the cerebellar GABA(A) receptors of an alcohol-sensitive ANT rat line. Alcohol Clin Exp Res. 1991 Mar;15(2):241-8. [PubMed:1647706 ]
  4. Miller EI, Wylie FM, Oliver JS: Detection of benzodiazepines in hair using ELISA and LC-ESI-MS-MS. J Anal Toxicol. 2006 Sep;30(7):441-8. [PubMed:16959136 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Glucuronosyltransferase activity
Specific Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidatio...
Gene Name:
UGT2B15
Uniprot ID:
P54855
Molecular Weight:
61035.815 Da
References
  1. Chung JY, Cho JY, Yu KS, Kim JR, Jung HR, Lim KS, Jang IJ, Shin SG: Effect of the UGT2B15 genotype on the pharmacokinetics, pharmacodynamics, and drug interactions of intravenous lorazepam in healthy volunteers. Clin Pharmacol Ther. 2005 Jun;77(6):486-94. [PubMed:15961980 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23