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Identification
NameSildenafil
Accession NumberDB00203  (APRD00556)
TypeSmall Molecule
GroupsApproved, Investigational
DescriptionSildenfail is a vasoactive agent used to treat erectile dysfunction and reduce symptoms in patients with pulmonary arterial hypertension (PAH). Sildenafil elevates levels of the second messenger, cGMP, by inhibiting its breakdown via phosphodiesterase type 5 (PDE5). PDE5 is found in particularly high concentrations in the corpus cavernosum, erectile tissue of the penis. It is also found in the retina and vascular endothelium. Increased cGMP results in vasodilation which facilitates generation and maintenance of an erection. The vasodilatory effects of sildenafil also help reduce symptoms of PAH.
Structure
Thumb
Synonyms
1-((3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-D)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Act Sildenafiltablet25 mgoralActavis Pharma Company2012-11-08Not applicableCanada
Act Sildenafiltablet50 mgoralActavis Pharma Company2012-11-08Not applicableCanada
Act Sildenafiltablet100 mgoralActavis Pharma Company2012-11-08Not applicableCanada
Auro-sildenafiltablet100 mgoralAuro Pharma IncNot applicableNot applicableCanada
Auro-sildenafiltablet25 mgoralAuro Pharma IncNot applicableNot applicableCanada
Auro-sildenafiltablet50 mgoralAuro Pharma IncNot applicableNot applicableCanada
Dom-sildenafiltablet50 mgoralDominion PharmacalNot applicableNot applicableCanada
Dom-sildenafiltablet100 mgoralDominion PharmacalNot applicableNot applicableCanada
Dom-sildenafiltablet25 mgoralDominion PharmacalNot applicableNot applicableCanada
Gd-sildenafiltablet25 mgoralGenmed A Division Of Pfizer Canada Inc2012-11-272015-08-03Canada
Gd-sildenafiltablet50 mgoralGenmed A Division Of Pfizer Canada Inc2012-11-272015-08-03Canada
Gd-sildenafiltablet100 mgoralGenmed A Division Of Pfizer Canada Inc2012-11-27Not applicableCanada
Ipg-sildenafiltablet50 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada
Ipg-sildenafiltablet100 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada
Ipg-sildenafiltablet25 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada
Jamp-sildenafiltablet25.0 mgoralJamp Pharma Corporation2014-12-05Not applicableCanada
Jamp-sildenafiltablet50.0 mgoralJamp Pharma Corporation2014-12-05Not applicableCanada
Jamp-sildenafiltablet100.0 mgoralJamp Pharma Corporation2014-12-05Not applicableCanada
M-sildenafiltablet100 mgoralMantra Pharma Inc2015-06-04Not applicableCanada
M-sildenafiltablet25 mgoralMantra Pharma IncNot applicableNot applicableCanada
M-sildenafiltablet50 mgoralMantra Pharma IncNot applicableNot applicableCanada
Mar-sildenafiltablet25.0 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Mar-sildenafiltablet50.0 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Mar-sildenafiltablet100.0 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Mint-sildenafiltablet100 mgoralMint Pharmaceuticals Inc2013-02-15Not applicableCanada
Mint-sildenafiltablet25 mgoralMint Pharmaceuticals Inc2013-02-15Not applicableCanada
Mint-sildenafiltablet50 mgoralMint Pharmaceuticals Inc2013-02-15Not applicableCanada
Myl-sildenafiltablet50 mgoralMylan Pharmaceuticals Ulc2012-11-20Not applicableCanada
Myl-sildenafiltablet100 mgoralMylan Pharmaceuticals Ulc2012-11-20Not applicableCanada
Myl-sildenafiltablet25 mgoralMylan Pharmaceuticals Ulc2012-11-20Not applicableCanada
Mylan-sildenafiltablet100 mgoralMylan Pharmaceuticals UlcNot applicableNot applicableCanada
Mylan-sildenafiltablet25 mgoralMylan Pharmaceuticals UlcNot applicableNot applicableCanada
Mylan-sildenafiltablet50 mgoralMylan Pharmaceuticals UlcNot applicableNot applicableCanada
Pb-sildenafiltablet25.0 mgoralPb Pharma IncNot applicableNot applicableCanada
Pb-sildenafiltablet50.0 mgoralPb Pharma IncNot applicableNot applicableCanada
Pb-sildenafiltablet100.0 mgoralPb Pharma IncNot applicableNot applicableCanada
PMS-sildenafiltablet25 mgoralPharmascience Inc2012-11-14Not applicableCanada
PMS-sildenafiltablet50 mgoralPharmascience Inc2012-11-14Not applicableCanada
PMS-sildenafiltablet100 mgoralPharmascience Inc2012-11-14Not applicableCanada
PMS-sildenafil Rtablet20 mgoralPharmascience Inc2014-11-14Not applicableCanada
Priva-sildenafiltablet50 mgoralPharmapar IncNot applicableNot applicableCanada
Priva-sildenafiltablet100 mgoralPharmapar IncNot applicableNot applicableCanada
Priva-sildenafiltablet25 mgoralPharmapar IncNot applicableNot applicableCanada
Ran-sildenafiltablet50 mgoralRanbaxy Pharmaceuticals Canada Inc.2012-11-21Not applicableCanada
Ran-sildenafiltablet100 mgoralRanbaxy Pharmaceuticals Canada Inc.2012-11-21Not applicableCanada
Ran-sildenafiltablet25 mgoralRanbaxy Pharmaceuticals Canada Inc.2012-11-21Not applicableCanada
Ratio-sildenafiltablet100 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ratio-sildenafiltablet25 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ratio-sildenafiltablet50 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ratio-sildenafil Rtablet20 mgoralTeva Canada Limited2010-06-09Not applicableCanada
RevatioSolution for injection0.8 mg/mlIntravenous usePfizer Limited2005-10-28Not applicableEu
Revatiopowder, for suspension10 mg/mLoralPfizer Laboratories Div Pfizer Inc2014-06-02Not applicableUs
RevatioPowder for oral suspension10 mg/mlOral usePfizer Limited2005-10-28Not applicableEu
Revatioinjection, solution.8 mg/mLintravenousPfizer Laboratories Div Pfizer Inc2009-11-18Not applicableUs
Revatiotablet20 mgoralPfizer Canada Inc2006-06-12Not applicableCanada
Revatiosolution0.8 mgintravenousPfizer Canada Inc2010-08-31Not applicableCanada
RevatioFilm-coated tablet20 mgOral usePfizer Limited2005-10-28Not applicableEu
Revatiotablet, film coated20 mg/1oralPfizer Laboratories Div Pfizer Inc2005-06-03Not applicableUs
RevatioFilm-coated tablet20 mgOral usePfizer Limited2005-10-28Not applicableEu
Revatiotablet, film coated20 mg/1oralCardinal Health2005-06-03Not applicableUs
Riva-sildenafiltablet100 mgoralLaboratoire Riva Inc2016-05-06Not applicableCanada
Riva-sildenafiltablet25 mgoralLaboratoire Riva IncNot applicableNot applicableCanada
Riva-sildenafiltablet25 mgoralLaboratoire Riva IncNot applicableNot applicableCanada
Riva-sildenafiltablet50 mgoralLaboratoire Riva IncNot applicableNot applicableCanada
Riva-sildenafiltablet50 mgoralLaboratoire Riva IncNot applicableNot applicableCanada
Riva-sildenafiltablet100 mgoralLaboratoire Riva IncNot applicableNot applicableCanada
Sandoz Sildenafiltablet25 mgoralSandoz Canada Incorporated2013-01-31Not applicableCanada
Sandoz Sildenafiltablet50 mgoralSandoz Canada Incorporated2013-01-31Not applicableCanada
Sandoz Sildenafiltablet100 mgoralSandoz Canada Incorporated2013-01-31Not applicableCanada
Sildenafiltablet, film coated20 mg/1oralGreenstone LLC2012-09-27Not applicableUs
Sildenafiltablet100 mgoralPharmascience Inc2013-08-05Not applicableCanada
Sildenafiltablet50 mgoralSanis Health Inc2013-06-21Not applicableCanada
Sildenafiltablet25 mgoralPro Doc LimiteeNot applicableNot applicableCanada
Sildenafiltablet25 mgoralSivem Pharmaceuticals UlcNot applicableNot applicableCanada
Sildenafiltablet25.0 mgoralJamp Pharma CorporationNot applicableNot applicableCanada
Sildenafiltablet100 mgoralPro Doc Limitee2014-10-07Not applicableCanada
Sildenafiltablet50 mgoralActavis Pharma CompanyNot applicableNot applicableCanada
Sildenafiltablet50 mgoralMethapharm IncNot applicableNot applicableCanada
Sildenafiltablet100 mgoralSanis Health Inc2013-06-21Not applicableCanada
Sildenafiltablet50 mgoralSivem Pharmaceuticals UlcNot applicableNot applicableCanada
Sildenafiltablet50.0 mgoralJamp Pharma CorporationNot applicableNot applicableCanada
Sildenafiltablet100 mgoralActavis Pharma CompanyNot applicableNot applicableCanada
Sildenafiltablet100 mgoralMethapharm IncNot applicableNot applicableCanada
Sildenafiltablet100 mgoralSivem Pharmaceuticals UlcNot applicableNot applicableCanada
Sildenafiltablet100.0 mgoralJamp Pharma CorporationNot applicableNot applicableCanada
Sildenafiltablet, film coated20 mg/1oralKAISER FOUNDATION HOSPITALS2014-09-19Not applicableUs
Sildenafiltablet50 mgoralPharmascience Inc2013-08-05Not applicableCanada
Sildenafiltablet, film coated20 mg/1oralPd Rx Pharmaceuticals, Inc.2012-09-27Not applicableUs
Sildenafiltablet25 mgoralPharmascience Inc2013-08-05Not applicableCanada
Sildenafiltablet50 mgoralPro Doc Limitee2014-10-07Not applicableCanada
Sildenafiltablet25 mgoralActavis Pharma CompanyNot applicableNot applicableCanada
Sildenafiltablet25 mgoralMethapharm IncNot applicableNot applicableCanada
Sildenafil Citratetablet25.0 mgoralJubilant Generics LimitedNot applicableNot applicableCanada
Sildenafil Citratetablet50.0 mgoralJubilant Generics LimitedNot applicableNot applicableCanada
Sildenafil Citratetablet100.0 mgoralJubilant Generics LimitedNot applicableNot applicableCanada
Sildenafil Rtablet20 mgoralMethapharm IncNot applicableNot applicableCanada
Sildenafil Tabletstablet50 mgoralDr Reddys Laboratories LtdNot applicableNot applicableCanada
Sildenafil Tabletstablet100 mgoralDr Reddys Laboratories LtdNot applicableNot applicableCanada
Sildenafil Tabletstablet25 mgoralDr Reddys Laboratories LtdNot applicableNot applicableCanada
Teva-sildenafiltablet50 mgoralTeva Canada Limited2012-11-08Not applicableCanada
Teva-sildenafiltablet100 mgoralTeva Canada Limited2012-11-08Not applicableCanada
Teva-sildenafiltablet25 mgoralTeva Canada Limited2012-11-08Not applicableCanada
Van-sildenafiltablet25.0 mgoralVanc Pharmaceuticals IncNot applicableNot applicableCanada
Van-sildenafiltablet50.0 mgoralVanc Pharmaceuticals IncNot applicableNot applicableCanada
Van-sildenafiltablet100 mgoralVanc Pharmaceuticals Inc2015-07-22Not applicableCanada
ViagraFilm-coated tablet50 mgOral usePfizer Limited1998-09-14Not applicableEu
Viagratablet, film coated50 mg/1oralRebel Distributors Corp2003-07-17Not applicableUs
Viagratablet100 mgoralPfizer Canada Inc1999-03-09Not applicableCanada
ViagraFilm-coated tablet50 mgOral usePfizer Limited1998-09-14Not applicableEu
ViagraFilm-coated tablet50 mgOral usePfizer Limited1998-09-14Not applicableEu
Viagratablet, film coated100 mg/1oralPhysicians Total Care, Inc.1998-03-27Not applicableUs
Viagratablet, film coated25 mg/1oralAphena Pharma Solutions Tennessee, Llc1998-03-27Not applicableUs
Viagratablet, film coated50 mg/1oralbryant ranch prepack1998-03-27Not applicableUs
ViagraFilm-coated tablet25 mgOral usePfizer Limited1998-09-14Not applicableEu
ViagraOrodispersible tablet50 mgOral usePfizer Limited1998-09-14Not applicableEu
Viagratablet, film coated50 mg/1oralPfizer Laboratories Div Pfizer Inc1998-03-27Not applicableUs
Viagratablet, film coated100 mg/1oralCardinal Health1998-03-27Not applicableUs
ViagraFilm-coated tablet25 mgOral usePfizer Limited1998-09-14Not applicableEu
Viagratablet, film coated50 mg/1oralU.S. Pharmaceuticals1998-03-27Not applicableUs
ViagraFilm-coated tablet50 mgOral usePfizer Limited1998-09-14Not applicableEu
Viagratablet, film coated100 mg/1oralRebel Distributors Corp2010-02-11Not applicableUs
Viagratablet, film coated25 mg/1oralPhysicians Total Care, Inc.1998-03-27Not applicableUs
ViagraFilm-coated tablet100 mgOral usePfizer Limited1998-09-14Not applicableEu
ViagraFilm-coated tablet100 mgOral usePfizer Limited1998-09-14Not applicableEu
ViagraOrodispersible tablet50 mgOral usePfizer Limited1998-09-14Not applicableEu
Viagratablet, film coated100 mg/1oralLake Erie Medical Surgical & Supply DBA Quality Care Products LLC2011-07-13Not applicableUs
Viagratablet, film coated50 mg/1oralAphena Pharma Solutions Tennessee, Llc1998-03-27Not applicableUs
ViagraFilm-coated tablet25 mgOral usePfizer Limited1998-09-14Not applicableEu
ViagraFilm-coated tablet50 mgOral usePfizer Limited1998-09-14Not applicableEu
Viagratablet, film coated100 mg/1oralPfizer Laboratories Div Pfizer Inc1998-03-27Not applicableUs
Viagratablet, film coated100 mg/1oralPd Rx Pharmaceuticals, Inc.1998-03-27Not applicableUs
Viagratablet, film coated25 mg/1oralPd Rx Pharmaceuticals, Inc.1998-03-27Not applicableUs
Viagratablet, film coated100 mg/1oralU.S. Pharmaceuticals1998-03-27Not applicableUs
ViagraFilm-coated tablet50 mgOral usePfizer Limited1998-09-14Not applicableEu
Viagratablet, film coated25 mg/1oralCardinal Health1998-03-27Not applicableUs
ViagraFilm-coated tablet100 mgOral usePfizer Limited1998-09-14Not applicableEu
ViagraFilm-coated tablet50 mgOral usePfizer Limited1998-09-14Not applicableEu
ViagraOrodispersible tablet50 mgOral usePfizer Limited1998-09-14Not applicableEu
Viagratablet, film coated100 mg/1oralREMEDYREPACK INC.2013-05-22Not applicableUs
Viagratablet, film coated100 mg/1oralAphena Pharma Solutions Tennessee, Llc1998-03-27Not applicableUs
ViagraFilm-coated tablet100 mgOral usePfizer Limited1998-09-14Not applicableEu
Viagratablet, film coated50 mg/1oralPd Rx Pharmaceuticals, Inc.1998-03-27Not applicableUs
Viagratablet, film coated100 mg/1oralbryant ranch prepack1998-03-27Not applicableUs
ViagraFilm-coated tablet25 mgOral usePfizer Limited1998-09-14Not applicableEu
ViagraFilm-coated tablet50 mgOral usePfizer Limited1998-09-14Not applicableEu
Viagratablet, film coated25 mg/1oralPfizer Laboratories Div Pfizer Inc1998-03-27Not applicableUs
ViagraFilm-coated tablet100 mgOral usePfizer Limited1998-09-14Not applicableEu
Viagratablet25 mgoralPfizer Canada Inc1999-03-09Not applicableCanada
ViagraFilm-coated tablet50 mgOral usePfizer Limited1998-09-14Not applicableEu
ViagraOrodispersible tablet50 mgOral usePfizer Limited1998-09-14Not applicableEu
Viagratablet, film coated50 mg/1oralPhysicians Total Care, Inc.1998-03-27Not applicableUs
Viagratablet50 mgoralPfizer Canada Inc1999-03-09Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-sildenafiltablet100 mgoralApotex Inc2012-11-09Not applicableCanada
Apo-sildenafiltablet25 mgoralApotex Inc2012-11-14Not applicableCanada
Apo-sildenafiltablet50 mgoralApotex Inc2012-11-14Not applicableCanada
Apo-sildenafil Rtablet20 mgoralApotex Inc2013-12-23Not applicableCanada
Sildenafiltablet, film coated20 mg/1oralAv Kare, Inc.2013-09-17Not applicableUs
Sildenafiltablet20 mg/1oralA S Medication Solutions2012-11-08Not applicableUs
Sildenafiltablet, film coated20 mg/1oralTeva Pharmaceuticals USA Inc2013-05-31Not applicableUs
Sildenafiltablet, film coated20 mg/1oralDIRECT RX2015-01-01Not applicableUs
Sildenafiltablet, film coated20 mg/1oralDr. Reddy's Laboratories Limited2012-11-12Not applicableUs
Sildenafiltablet, film coated20 mg/1oralNorthstar Rx LLC2013-02-26Not applicableUs
Sildenafiltablet20 mg/1oralBlue Point Laboratories2014-02-04Not applicableUs
Sildenafiltablet, film coated20 mg/1oralProficient Rx LP2014-11-26Not applicableUs
Sildenafiltablet20 mg/1oralAv Pak2015-05-29Not applicableUs
Sildenafiltablet, film coated20 mg/1oralMylan Pharmaceuticals Inc.2012-11-09Not applicableUs
Sildenafiltablet20 mg/1oralbryant ranch prepack2012-11-08Not applicableUs
Sildenafilinjection, solution10 mg/12.5mLintravenousAuro Medics Pharma Llc2015-04-01Not applicableUs
Sildenafiltablet, film coated20 mg/1oralCamber Pharmaceuticals, Inc.2014-11-26Not applicableUs
Sildenafiltablet20 mg/1oralAmerican Health Packaging2015-02-15Not applicableUs
Sildenafiltablet, film coated20 mg/1oralNorthwind Pharmaceuticals, LLC2014-11-06Not applicableUs
Sildenafiltablet, film coated20 mg/1oralActavis Pharma, Inc.2012-11-06Not applicableUs
Sildenafiltablet20 mg/1oralAmneal Pharmaceuticals of New York, LLC2012-11-08Not applicableUs
Sildenafiltablet, film coated20 mg/1oralApotex Corp.2012-11-06Not applicableUs
Sildenafiltablet, film coated20 mg/1oralPd Rx Pharmaceuticals, Inc.2013-05-31Not applicableUs
Sildenafiltablet, film coated20 mg/1oralMacleods Pharmaceuticals Limited2014-01-03Not applicableUs
Sildenafiltablet, film coated20 mg/1oralREMEDYREPACK INC.2013-09-19Not applicableUs
Sildenafiltablet, film coated20 mg/1oralAurobindo Pharma Limited2015-11-18Not applicableUs
Sildenafiltablet, film coated20 mg/1oralREMEDYREPACK INC.2015-12-10Not applicableUs
Sildenafiltablet, film coated20 mg/1oralPreferred Pharmaceuticals Inc.2016-04-14Not applicableUs
Sildenafil Citratetablet, film coated20 mg/1oralAmerican Health Packaging2012-12-142016-01-05Us
Sildenafil Citratetablet20 mg/1oralTorrent Pharmaceuticals Limited2012-11-06Not applicableUs
Sildenafil RatiopharmFilm-coated tablet50 mgOral useRatiopharm Gmb H2009-12-23Not applicableEu
Sildenafil RatiopharmFilm-coated tablet100 mgOral useRatiopharm Gmb H2009-12-23Not applicableEu
Sildenafil RatiopharmFilm-coated tablet25 mgOral useRatiopharm Gmb H2009-12-23Not applicableEu
Sildenafil RatiopharmFilm-coated tablet100 mgOral useRatiopharm Gmb H2009-12-23Not applicableEu
Sildenafil RatiopharmFilm-coated tablet50 mgOral useRatiopharm Gmb H2009-12-23Not applicableEu
Sildenafil RatiopharmFilm-coated tablet100 mgOral useRatiopharm Gmb H2009-12-23Not applicableEu
Sildenafil RatiopharmFilm-coated tablet50 mgOral useRatiopharm Gmb H2009-12-23Not applicableEu
Sildenafil RatiopharmFilm-coated tablet25 mgOral useRatiopharm Gmb H2009-12-23Not applicableEu
Sildenafil RatiopharmFilm-coated tablet25 mgOral useRatiopharm Gmb H2009-12-23Not applicableEu
Sildenafil RatiopharmFilm-coated tablet50 mgOral useRatiopharm Gmb H2009-12-23Not applicableEu
Sildenafil RatiopharmFilm-coated tablet100 mgOral useRatiopharm Gmb H2009-12-23Not applicableEu
Sildenafil RatiopharmFilm-coated tablet100 mgOral useRatiopharm Gmb H2009-12-23Not applicableEu
Sildenafil RatiopharmFilm-coated tablet25 mgOral useRatiopharm Gmb H2009-12-23Not applicableEu
Sildenafil RatiopharmFilm-coated tablet50 mgOral useRatiopharm Gmb H2009-12-23Not applicableEu
Sildenafil RatiopharmFilm-coated tablet50 mgOral useRatiopharm Gmb H2009-12-23Not applicableEu
Sildenafil RatiopharmFilm-coated tablet100 mgOral useRatiopharm Gmb H2009-12-23Not applicableEu
Sildenafil RatiopharmFilm-coated tablet25 mgOral useRatiopharm Gmb H2009-12-23Not applicableEu
Sildenafil RatiopharmFilm-coated tablet100 mgOral useRatiopharm Gmb H2009-12-23Not applicableEu
Sildenafil TevaFilm-coated tablet25 mgOral useTeva B.V.  2009-11-30Not applicableEu
Sildenafil TevaFilm-coated tablet100 mgOral useTeva B.V.  2009-11-30Not applicableEu
Sildenafil TevaFilm-coated tablet50 mgOral useTeva B.V.  2009-11-30Not applicableEu
Sildenafil TevaFilm-coated tablet25 mgOral useTeva B.V.  2009-11-30Not applicableEu
Sildenafil TevaFilm-coated tablet100 mgOral useTeva B.V.  2009-11-30Not applicableEu
Sildenafil TevaFilm-coated tablet50 mgOral useTeva B.V.  2009-11-30Not applicableEu
Sildenafil TevaFilm-coated tablet100 mgOral useTeva B.V.  2009-11-30Not applicableEu
Sildenafil TevaFilm-coated tablet50 mgOral useTeva B.V.  2009-11-30Not applicableEu
Sildenafil TevaFilm-coated tablet25 mgOral useTeva B.V.  2009-11-30Not applicableEu
Sildenafil TevaFilm-coated tablet50 mgOral useTeva B.V.  2009-11-30Not applicableEu
Sildenafil TevaFilm-coated tablet100 mgOral useTeva B.V.  2009-11-30Not applicableEu
Sildenafil TevaFilm-coated tablet100 mgOral useTeva B.V.  2009-11-30Not applicableEu
Sildenafil TevaFilm-coated tablet25 mgOral useTeva B.V.  2009-11-30Not applicableEu
Sildenafil TevaFilm-coated tablet50 mgOral useTeva B.V.  2009-11-30Not applicableEu
Sildenafil TevaFilm-coated tablet25 mgOral useTeva B.V.  2009-11-30Not applicableEu
Sildenafil TevaFilm-coated tablet50 mgOral useTeva B.V.  2009-11-30Not applicableEu
Sildenafil TevaFilm-coated tablet100 mgOral useTeva B.V.  2009-11-30Not applicableEu
VizarsinFilm-coated tablet25 mgOral useKrka, D.D., Novo Mesto2009-09-21Not applicableEu
VizarsinOrodispersible tablet50 mgOral useKrka, D.D., Novo Mesto2009-09-21Not applicableEu
VizarsinFilm-coated tablet100 mgOral useKrka, D.D., Novo Mesto2009-09-21Not applicableEu
VizarsinOrodispersible tablet100 mgOral useKrka, D.D., Novo Mesto2009-09-21Not applicableEu
VizarsinFilm-coated tablet50 mgOral useKrka, D.D., Novo Mesto2009-09-21Not applicableEu
VizarsinOrodispersible tablet50 mgOral useKrka, D.D., Novo Mesto2009-09-21Not applicableEu
VizarsinOrodispersible tablet25 mgOral useKrka, D.D., Novo Mesto2009-09-21Not applicableEu
VizarsinFilm-coated tablet25 mgOral useKrka, D.D., Novo Mesto2009-09-21Not applicableEu
VizarsinOrodispersible tablet50 mgOral useKrka, D.D., Novo Mesto2009-09-21Not applicableEu
VizarsinFilm-coated tablet100 mgOral useKrka, D.D., Novo Mesto2009-09-21Not applicableEu
VizarsinOrodispersible tablet100 mgOral useKrka, D.D., Novo Mesto2009-09-21Not applicableEu
VizarsinFilm-coated tablet50 mgOral useKrka, D.D., Novo Mesto2009-09-21Not applicableEu
VizarsinOrodispersible tablet100 mgOral useKrka, D.D., Novo Mesto2009-09-21Not applicableEu
VizarsinFilm-coated tablet25 mgOral useKrka, D.D., Novo Mesto2009-09-21Not applicableEu
VizarsinOrodispersible tablet25 mgOral useKrka, D.D., Novo Mesto2009-09-21Not applicableEu
VizarsinFilm-coated tablet50 mgOral useKrka, D.D., Novo Mesto2009-09-21Not applicableEu
VizarsinOrodispersible tablet50 mgOral useKrka, D.D., Novo Mesto2009-09-21Not applicableEu
VizarsinOrodispersible tablet25 mgOral useKrka, D.D., Novo Mesto2009-09-21Not applicableEu
VizarsinOrodispersible tablet50 mgOral useKrka, D.D., Novo Mesto2009-09-21Not applicableEu
VizarsinFilm-coated tablet100 mgOral useKrka, D.D., Novo Mesto2009-09-21Not applicableEu
VizarsinOrodispersible tablet100 mgOral useKrka, D.D., Novo Mesto2009-09-21Not applicableEu
VizarsinFilm-coated tablet25 mgOral useKrka, D.D., Novo Mesto2009-09-21Not applicableEu
VizarsinOrodispersible tablet25 mgOral useKrka, D.D., Novo Mesto2009-09-21Not applicableEu
VizarsinFilm-coated tablet50 mgOral useKrka, D.D., Novo Mesto2009-09-21Not applicableEu
VizarsinOrodispersible tablet50 mgOral useKrka, D.D., Novo Mesto2009-09-21Not applicableEu
VizarsinOrodispersible tablet25 mgOral useKrka, D.D., Novo Mesto2009-09-21Not applicableEu
VizarsinOrodispersible tablet100 mgOral useKrka, D.D., Novo Mesto2009-09-21Not applicableEu
VizarsinFilm-coated tablet100 mgOral useKrka, D.D., Novo Mesto2009-09-21Not applicableEu
VizarsinOrodispersible tablet100 mgOral useKrka, D.D., Novo Mesto2009-09-21Not applicableEu
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Sildenafil Citrate
171599-83-0
Thumb
  • InChI Key: DEIYFTQMQPDXOT-UHFFFAOYSA-N
  • Monoisotopic Mass: 666.231926778
  • Average Mass: 666.7
DBSALT000347
Categories
UNII3M7OB98Y7H
CAS number139755-83-2
WeightAverage: 474.576
Monoisotopic: 474.204924168
Chemical FormulaC22H30N6O4S
InChI KeyInChIKey=BNRNXUUZRGQAQC-UHFFFAOYSA-N
InChI
InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)
IUPAC Name
5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1H,4H,7H-pyrazolo[4,3-d]pyrimidin-7-one
SMILES
CCCC1=NN(C)C2=C1NC(=NC2=O)C1=C(OCC)C=CC(=C1)S(=O)(=O)N1CCN(C)CC1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as benzenesulfonamides. These are organic compounds containing a sulfonamide group that is S-linked to a benzene ring.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBenzenesulfonamides
Direct ParentBenzenesulfonamides
Alternative Parents
Substituents
  • Benzenesulfonamide
  • Pyrazolopyrimidine
  • Phenol ether
  • N-alkylpiperazine
  • N-methylpiperazine
  • Pyrimidone
  • Alkyl aryl ether
  • Pyrimidine
  • Piperazine
  • 1,4-diazinane
  • Heteroaromatic compound
  • Vinylogous amide
  • Sulfonyl
  • Sulfonic acid derivative
  • Sulfonamide
  • Pyrazole
  • Azole
  • Tertiary aliphatic amine
  • Tertiary amine
  • Azacycle
  • Organoheterocyclic compound
  • Ether
  • Hydrocarbon derivative
  • Organosulfur compound
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of erectile dysfunction and to relieve symptoms of pulmonary arterial hypertension (PAH).
PharmacodynamicsErections are controlled by the parasympathetic nervous system. Upon sexual stimulation, a decrease in vascular resistance is mediated by acetylcholine and nitric oxide resulting in vasodilation. The hemodynamic mechanism of an erection is comprised of five stages. During the latent stage, arterial and carvernous smooth muscle relaxation occurs. Vasodilation results in high levels of blood flow causing the penis to grow to its full size. This stage is called tumescence. During the full-erection stage, blood flow fills penis sinusoids and outflow is restricted. This is followed by the rigid-erection phase during which the cavernous muscles contract causing the penis to become rigid. Little blood flow occurs during this stage. During the final stage, detumescence, the cavernous muscles relax and blood flows out of the penis. Erectile dysfunction may occur when there is insufficient blood supply to the penis or when the penis is unable to prevent outflow of blood from the penis. Sildenafil is a specific inhibitor of PDE5, an enzyme responsible for the breakdown of cGMP to 5’-GMP. Increased levels of cGMP stimulate vasodilation and facilitate the generation and maintenance of erections. These vasodilatory effects also help decrease symptoms of PAH. Sildenfail also exhibits some activity against PDE6 (10 times less potentcy compared to PDE5), a PDE isoform found predmoninantly in the retina. This activity is responsible for the blue tinged vision experienced by users of sildenafil.
Mechanism of actionSildenafil inhibits the cGMP-specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by sildenafil enhances erectile function by increasing the amount of cGMP.
Related Articles
Absorption>90% absorbed with ~40% reaching systemic circulation unchanged following first-pass metabolism
Volume of distribution
  • 105 L
Protein binding96%
Metabolism

Sildenafil appears to be completely metabolized in the liver to 16 metabolites. Its metabolism is mediated mainly by cytochrome P450 microsomal isozymes 3A4 (major route) and 2C9 (minor route). The major circulating metabolite, N-demethylated metabolite, has PDE selectivity similar to the parent drug and ~50% of its in vitro potency. The N-demethylated metabolite is further metabolized to an N-dealkylated N,N-de-ethylated metabolite. Sildenafil also undergoes N-dealkylation followed by N-demethylation of the piperazine ring.

SubstrateEnzymesProduct
Sildenafil
N-Desmethyl sildenafil (UK-103,320)Details
Route of eliminationSildenafil is cleared predominantly by the CYP3A (major route) and cytochrome P450 2C9 (CYP2C9, minor route) hepatic microsomal isoenzymes. After either oral or intravenous administration, sildenafil is excreted as metabolites predominantly in the feces (approximately 80% of the administered oral dose) and to a lesser extent in the urine (approximately 13% of the administered oral dose).
Half life4 hours
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated Effects
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeEffectReference(s)
Angiotensin-converting enzyme
Gene symbol: ACE
UniProt: P12821
rs1799752 Not AvailableAlu insertionsBetter response to drug treatment12837457
Angiotensin-converting enzyme
Gene symbol: ACE
UniProt: P12821
rs4340 Not AvailableAlu insertionsBetter response to drug treatment12837457
Angiotensin-converting enzyme
Gene symbol: ACE
UniProt: P12821
rs13447447 Not AvailableAlu insertionsBetter response to drug treatment12837457
Angiotensin-converting enzyme
Gene symbol: ACE
UniProt: P12821
rs4646994 Not AvailableAlu insertionsBetter response to drug treatment12837457
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
Gene symbol: GNB3
UniProt: P16520
rs5443 Not AvailableT AlleleBetter response to drug treatment12576843
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
Gene symbol: GNB3
UniProt: P16520
rs5443 Not AvailableTT alleleBetter response to drug treatment. More patients experience a 'postive erectile response'12576843
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.6461
Caco-2 permeable+0.7078
P-glycoprotein substrateSubstrate0.7753
P-glycoprotein inhibitor IInhibitor0.672
P-glycoprotein inhibitor IIInhibitor0.8877
Renal organic cation transporterNon-inhibitor0.648
CYP450 2C9 substrateNon-substrate0.6553
CYP450 2D6 substrateSubstrate0.8918
CYP450 3A4 substrateSubstrate0.7254
CYP450 1A2 substrateNon-inhibitor0.823
CYP450 2C9 inhibitorInhibitor0.6864
CYP450 2D6 inhibitorNon-inhibitor0.8394
CYP450 2C19 inhibitorNon-inhibitor0.8222
CYP450 3A4 inhibitorInhibitor0.849
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.5839
Ames testNon AMES toxic0.5683
CarcinogenicityNon-carcinogens0.6658
BiodegradationNot ready biodegradable0.7641
Rat acute toxicity2.6730 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8664
hERG inhibition (predictor II)Inhibitor0.7602
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
Packagers
Dosage forms
FormRouteStrength
Tabletoral25 mg
Tabletoral100.0 mg
Tabletoral25.0 mg
Tabletoral50.0 mg
Film-coated tabletOral use20 mg
Injection, solutionintravenous.8 mg/mL
Powder for oral suspensionOral use10 mg/ml
Powder, for suspensionoral10 mg/mL
Solutionintravenous0.8 mg
Solution for injectionIntravenous use0.8 mg/ml
Tabletoral20 mg
Tablet, film coatedoral20 mg/1
Injection, solutionintravenous10 mg/12.5mL
Tabletoral20 mg/1
Film-coated tabletOral use100 mg
Film-coated tabletOral use25 mg
Film-coated tabletOral use50 mg
Orodispersible tabletOral use50 mg
Tabletoral100 mg
Tabletoral50 mg
Tablet, film coatedoral100 mg/1
Tablet, film coatedoral25 mg/1
Tablet, film coatedoral50 mg/1
Orodispersible tabletOral use100 mg
Orodispersible tabletOral use25 mg
Prices
Unit descriptionCostUnit
Sildenafil citrate powder24.38USD g
Viagra 50 mg tablet19.45USD tablet
Viagra 100 mg tablet19.45USD tablet
Viagra 25 mg tablet19.45USD tablet
Revatio 20 mg tablet17.5USD tablet
Revatio 10 mg/12.5 ml vial9.33USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2044748 No1998-02-032011-06-17Canada
CA2324324 No2005-12-202020-10-26Canada
US5250534 No1995-03-272012-03-27Us
US6469012 Yes2000-04-222020-04-22Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point189-190 °CNot Available
water solubility3.5 mg/mLNot Available
logP1.9Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.433 mg/mLALOGPS
logP2.35ALOGPS
logP1.65ChemAxon
logS-3ALOGPS
pKa (Strongest Acidic)7.27ChemAxon
pKa (Strongest Basic)5.97ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count8ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area109.13 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity139.44 m3·mol-1ChemAxon
Polarizability51.18 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-004i-0002900000-b281f59f40caaba85ac9View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-004i-4436900000-0c5804e76b9d495c76d6View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0459-6292000000-5a32bfcdda2067978be9View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-00di-0001900000-51b4957d0b3d25c41773View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-01vk-0302900000-86c63c2fd17f7c5b7d6fView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-03dj-8916100000-e941afc576d544ed32a7View in MoNA
References
Synthesis Reference

Peter James Dunn, Albert Shaw Wood, “Process for preparing sildenafil.” U.S. Patent US5955611, issued December, 1994.

US5955611
General References
  1. Boolell M, Allen MJ, Ballard SA, Gepi-Attee S, Muirhead GJ, Naylor AM, Osterloh IH, Gingell C: Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Int J Impot Res. 1996 Jun;8(2):47-52. [PubMed:8858389 ]
  2. Cheitlin MD, Hutter AM Jr, Brindis RG, Ganz P, Kaul S, Russell RO Jr, Zusman RM: ACC/AHA expert consensus document. Use of sildenafil (Viagra) in patients with cardiovascular disease. American College of Cardiology/American Heart Association. J Am Coll Cardiol. 1999 Jan;33(1):273-82. [PubMed:9935041 ]
  3. Fries R, Shariat K, von Wilmowsky H, Bohm M: Sildenafil in the treatment of Raynaud's phenomenon resistant to vasodilatory therapy. Circulation. 2005 Nov 8;112(19):2980-5. [PubMed:16275885 ]
External Links
ATC CodesG04BE03
AHFS Codes
  • 24:12.12
PDB EntriesNot Available
FDA labelDownload (80.5 KB)
MSDSDownload (37.1 KB)
Interactions
Drug Interactions
Drug
1,10-PhenanthrolineThe serum concentration of Sildenafil can be increased when it is combined with 1,10-Phenanthroline.
3,4-DichloroisocoumarinThe serum concentration of Sildenafil can be increased when it is combined with 3,4-Dichloroisocoumarin.
4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDEThe serum concentration of Sildenafil can be increased when it is combined with 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE.
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Sildenafil.
AcebutololSildenafil may increase the antihypertensive activities of Acebutolol.
AceclofenacThe metabolism of Aceclofenac can be decreased when combined with Sildenafil.
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Sildenafil.
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Sildenafil.
Acetylsalicylic acidThe metabolism of Acetylsalicylic acid can be decreased when combined with Sildenafil.
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Sildenafil.
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Sildenafil.
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Sildenafil.
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Sildenafil.
AlfuzosinThe metabolism of Alfuzosin can be decreased when combined with Sildenafil.
AliskirenSildenafil may increase the antihypertensive activities of Aliskiren.
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Sildenafil.
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Sildenafil.
AlogliptinThe serum concentration of Sildenafil can be increased when it is combined with Alogliptin.
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Sildenafil.
AlosetronThe metabolism of Alosetron can be decreased when combined with Sildenafil.
Alpha-1-proteinase inhibitorThe serum concentration of Sildenafil can be increased when it is combined with Alpha-1-proteinase inhibitor.
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Sildenafil.
AlprenololSildenafil may increase the antihypertensive activities of Alprenolol.
AlprostadilThe risk or severity of adverse effects can be increased when Sildenafil is combined with Alprostadil.
AmbrisentanSildenafil may increase the antihypertensive activities of Ambrisentan.
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Sildenafil.
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Sildenafil.
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Sildenafil.
AmiodaroneThe metabolism of Amiodarone can be decreased when combined with Sildenafil.
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Sildenafil.
AmlodipineSildenafil may increase the antihypertensive activities of Amlodipine.
AmprenavirThe serum concentration of Sildenafil can be increased when it is combined with Amprenavir.
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Sildenafil.
Amyl NitriteSildenafil may increase the vasodilatory activities of Amyl Nitrite.
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Sildenafil.
Antithrombin III humanThe serum concentration of Sildenafil can be increased when it is combined with Antithrombin III human.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Sildenafil.
ApremilastThe metabolism of Apremilast can be decreased when combined with Sildenafil.
AprepitantThe serum concentration of Sildenafil can be increased when it is combined with Aprepitant.
AprepitantThe metabolism of Aprepitant can be decreased when combined with Sildenafil.
AprotininThe serum concentration of Sildenafil can be increased when it is combined with Aprotinin.
Arachidonic AcidThe metabolism of Arachidonic Acid can be decreased when combined with Sildenafil.
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Sildenafil.
ArgatrobanThe serum concentration of Sildenafil can be increased when it is combined with Argatroban.
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Sildenafil.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Sildenafil.
ArmodafinilThe metabolism of Sildenafil can be decreased when combined with Armodafinil.
ArtemetherThe metabolism of Artemether can be decreased when combined with Sildenafil.
AsenapineThe metabolism of Asenapine can be decreased when combined with Sildenafil.
AstemizoleThe metabolism of Astemizole can be decreased when combined with Sildenafil.
AsunaprevirThe serum concentration of Sildenafil can be increased when it is combined with Asunaprevir.
AtazanavirThe serum concentration of Sildenafil can be increased when it is combined with Atazanavir.
AtazanavirThe metabolism of Atazanavir can be decreased when combined with Sildenafil.
AtenololSildenafil may increase the antihypertensive activities of Atenolol.
AtomoxetineThe metabolism of Sildenafil can be decreased when combined with Atomoxetine.
AtorvastatinThe metabolism of Atorvastatin can be decreased when combined with Sildenafil.
AvanafilThe metabolism of Avanafil can be decreased when combined with Sildenafil.
AxitinibThe metabolism of Axitinib can be decreased when combined with Sildenafil.
AzelastineThe metabolism of Azelastine can be decreased when combined with Sildenafil.
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Sildenafil.
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Sildenafil.
BatimastatThe serum concentration of Sildenafil can be increased when it is combined with Batimastat.
BedaquilineThe metabolism of Bedaquiline can be decreased when combined with Sildenafil.
BenazeprilThe serum concentration of Sildenafil can be increased when it is combined with Benazepril.
BenazeprilSildenafil may increase the antihypertensive activities of Benazepril.
BendroflumethiazideSildenafil may increase the antihypertensive activities of Bendroflumethiazide.
BenzamidineThe serum concentration of Sildenafil can be increased when it is combined with Benzamidine.
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Sildenafil.
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Sildenafil.
BepridilSildenafil may increase the antihypertensive activities of Bepridil.
BetaxololSildenafil may increase the antihypertensive activities of Betaxolol.
BetaxololThe metabolism of Sildenafil can be decreased when combined with Betaxolol.
BethanidineSildenafil may increase the antihypertensive activities of Bethanidine.
BexaroteneThe serum concentration of Sildenafil can be decreased when it is combined with Bexarotene.
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Sildenafil.
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Sildenafil.
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Sildenafil.
BimatoprostSildenafil may increase the antihypertensive activities of Bimatoprost.
BisoprololSildenafil may increase the antihypertensive activities of Bisoprolol.
BivalirudinThe serum concentration of Sildenafil can be increased when it is combined with Bivalirudin.
BoceprevirThe serum concentration of Sildenafil can be increased when it is combined with Boceprevir.
BoceprevirThe metabolism of Boceprevir can be decreased when combined with Sildenafil.
BortezomibThe metabolism of Sildenafil can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Sildenafil can be decreased when it is combined with Bosentan.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Sildenafil.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Sildenafil.
Brentuximab vedotinThe metabolism of Brentuximab vedotin can be decreased when combined with Sildenafil.
BretyliumSildenafil may increase the antihypertensive activities of Bretylium.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Sildenafil.
BrimonidineSildenafil may increase the antihypertensive activities of Brimonidine.
BrinzolamideThe metabolism of Brinzolamide can be decreased when combined with Sildenafil.
BromazepamThe metabolism of Bromazepam can be decreased when combined with Sildenafil.
BromocriptineThe metabolism of Bromocriptine can be decreased when combined with Sildenafil.
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Sildenafil.
BudesonideThe metabolism of Budesonide can be decreased when combined with Sildenafil.
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Sildenafil.
BupranololSildenafil may increase the antihypertensive activities of Bupranolol.
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Sildenafil.
BupropionThe metabolism of Bupropion can be decreased when combined with Sildenafil.
BuspironeThe metabolism of Buspirone can be decreased when combined with Sildenafil.
BusulfanThe metabolism of Busulfan can be decreased when combined with Sildenafil.
CabazitaxelThe metabolism of Cabazitaxel can be decreased when combined with Sildenafil.
CabergolineThe metabolism of Cabergoline can be decreased when combined with Sildenafil.
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Sildenafil.
CaffeineThe metabolism of Caffeine can be decreased when combined with Sildenafil.
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Sildenafil.
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Sildenafil.
CandesartanSildenafil may increase the antihypertensive activities of Candesartan.
CandoxatrilThe serum concentration of Sildenafil can be increased when it is combined with Candoxatril.
CandoxatrilSildenafil may increase the antihypertensive activities of Candoxatril.
CapecitabineThe metabolism of Sildenafil can be decreased when combined with Capecitabine.
CaptoprilThe serum concentration of Sildenafil can be increased when it is combined with Captopril.
CaptoprilSildenafil may increase the antihypertensive activities of Captopril.
CarbamazepineThe metabolism of Sildenafil can be increased when combined with Carbamazepine.
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Sildenafil.
CariprazineThe metabolism of Cariprazine can be decreased when combined with Sildenafil.
CarteololSildenafil may increase the antihypertensive activities of Carteolol.
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Sildenafil.
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Sildenafil.
CeliprololSildenafil may increase the antihypertensive activities of Celiprolol.
CephalexinThe metabolism of Cephalexin can be decreased when combined with Sildenafil.
CeritinibThe serum concentration of Sildenafil can be increased when it is combined with Ceritinib.
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Sildenafil.
CevimelineThe metabolism of Cevimeline can be decreased when combined with Sildenafil.
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Sildenafil.
ChloramphenicolThe metabolism of Sildenafil can be decreased when combined with Chloramphenicol.
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Sildenafil.
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Sildenafil.
ChlorothiazideSildenafil may increase the antihypertensive activities of Chlorothiazide.
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Sildenafil.
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Sildenafil.
ChlorpropamideThe metabolism of Chlorpropamide can be decreased when combined with Sildenafil.
ChlorthalidoneSildenafil may increase the antihypertensive activities of Chlorthalidone.
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Sildenafil.
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Sildenafil.
ChymostatinThe serum concentration of Sildenafil can be increased when it is combined with Chymostatin.
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Sildenafil.
CilastatinThe serum concentration of Sildenafil can be increased when it is combined with Cilastatin.
CilazaprilThe serum concentration of Sildenafil can be increased when it is combined with Cilazapril.
CilazaprilSildenafil may increase the antihypertensive activities of Cilazapril.
CilostazolThe metabolism of Cilostazol can be decreased when combined with Sildenafil.
CimetidineThe metabolism of Sildenafil can be decreased when combined with Cimetidine.
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Sildenafil.
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Sildenafil.
CisaprideThe metabolism of Cisapride can be decreased when combined with Sildenafil.
CitalopramThe metabolism of Citalopram can be decreased when combined with Sildenafil.
ClarithromycinThe serum concentration of Sildenafil can be increased when it is combined with Clarithromycin.
ClarithromycinThe metabolism of Clarithromycin can be decreased when combined with Sildenafil.
ClemastineThe metabolism of Sildenafil can be decreased when combined with Clemastine.
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Sildenafil.
ClobazamThe metabolism of Clobazam can be decreased when combined with Sildenafil.
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Sildenafil.
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Sildenafil.
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Sildenafil.
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Sildenafil.
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Sildenafil.
ClonidineSildenafil may increase the antihypertensive activities of Clonidine.
ClopidogrelThe metabolism of Clopidogrel can be decreased when combined with Sildenafil.
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Sildenafil.
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Sildenafil.
ClotrimazoleThe metabolism of Sildenafil can be decreased when combined with Clotrimazole.
ClozapineThe metabolism of Clozapine can be decreased when combined with Sildenafil.
CobicistatThe serum concentration of Sildenafil can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Sildenafil.
CocaineThe metabolism of Cocaine can be decreased when combined with Sildenafil.
CodeineThe metabolism of Codeine can be decreased when combined with Sildenafil.
ColchicineThe metabolism of Colchicine can be decreased when combined with Sildenafil.
ConivaptanThe serum concentration of Sildenafil can be increased when it is combined with Conivaptan.
ConivaptanThe metabolism of Conivaptan can be decreased when combined with Sildenafil.
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be decreased when combined with Sildenafil.
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Sildenafil.
CrizotinibThe metabolism of Crizotinib can be decreased when combined with Sildenafil.
CryptenamineSildenafil may increase the antihypertensive activities of Cryptenamine.
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Sildenafil.
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Sildenafil.
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Sildenafil.
CyclothiazideSildenafil may increase the antihypertensive activities of Cyclothiazide.
Cyproterone acetateThe serum concentration of Sildenafil can be decreased when it is combined with Cyproterone acetate.
CytarabineThe metabolism of Cytarabine can be decreased when combined with Sildenafil.
Dabigatran etexilateThe serum concentration of Sildenafil can be increased when it is combined with Dabigatran etexilate.
DabrafenibThe serum concentration of Sildenafil can be decreased when it is combined with Dabrafenib.
DabrafenibThe metabolism of Dabrafenib can be decreased when combined with Sildenafil.
DaclatasvirThe metabolism of Daclatasvir can be decreased when combined with Sildenafil.
DantroleneThe metabolism of Dantrolene can be decreased when combined with Sildenafil.
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Sildenafil.
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Sildenafil.
DapoxetineDapoxetine may increase the orthostatic hypotensive activities of Sildenafil.
DapsoneThe metabolism of Dapsone can be decreased when combined with Sildenafil.
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Sildenafil.
DarunavirThe serum concentration of Sildenafil can be increased when it is combined with Darunavir.
DarunavirThe metabolism of Darunavir can be decreased when combined with Sildenafil.
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Sildenafil.
DasatinibThe serum concentration of Sildenafil can be increased when it is combined with Dasatinib.
DasatinibThe metabolism of Dasatinib can be decreased when combined with Sildenafil.
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Sildenafil.
DebrisoquinSildenafil may increase the antihypertensive activities of Debrisoquin.
DeferasiroxThe serum concentration of Sildenafil can be decreased when it is combined with Deferasirox.
DehydroepiandrosteroneThe metabolism of Dehydroepiandrosterone can be decreased when combined with Sildenafil.
DelavirdineThe metabolism of Delavirdine can be decreased when combined with Sildenafil.
DeserpidineSildenafil may increase the antihypertensive activities of Deserpidine.
DesipramineThe metabolism of Sildenafil can be decreased when combined with Desipramine.
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Sildenafil.
DexamethasoneThe serum concentration of Sildenafil can be decreased when it is combined with Dexamethasone.
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Sildenafil.
DexketoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sildenafil.
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Sildenafil.
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Sildenafil.
DiazepamThe metabolism of Diazepam can be decreased when combined with Sildenafil.
DiazoxideSildenafil may increase the antihypertensive activities of Diazoxide.
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Sildenafil.
DicoumarolThe metabolism of Dicoumarol can be decreased when combined with Sildenafil.
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Sildenafil.
DigoxinThe metabolism of Digoxin can be decreased when combined with Sildenafil.
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Sildenafil.
DihydroergotamineThe metabolism of Sildenafil can be decreased when combined with Dihydroergotamine.
DiltiazemSildenafil may increase the antihypertensive activities of Diltiazem.
DiltiazemThe metabolism of Sildenafil can be decreased when combined with Diltiazem.
DiphenhydramineThe metabolism of Sildenafil can be decreased when combined with Diphenhydramine.
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Sildenafil.
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Sildenafil.
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Sildenafil.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Sildenafil.
DolasetronThe metabolism of Dolasetron can be decreased when combined with Sildenafil.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Sildenafil.
DonepezilThe metabolism of Donepezil can be decreased when combined with Sildenafil.
DopamineThe metabolism of Dopamine can be decreased when combined with Sildenafil.
DorzolamideSildenafil may increase the antihypertensive activities of Dorzolamide.
DoxazosinSildenafil may increase the antihypertensive activities of Doxazosin.
DoxepinThe metabolism of Doxepin can be decreased when combined with Sildenafil.
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Sildenafil.
DoxycyclineThe metabolism of Sildenafil can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Sildenafil.
DronedaroneThe metabolism of Dronedarone can be decreased when combined with Sildenafil.
DuloxetineThe metabolism of Sildenafil can be decreased when combined with Duloxetine.
DutasterideThe metabolism of Dutasteride can be decreased when combined with Sildenafil.
EcabetThe serum concentration of Sildenafil can be increased when it is combined with Ecabet.
EdoxabanThe serum concentration of Sildenafil can be increased when it is combined with Edoxaban.
EfavirenzThe serum concentration of Sildenafil can be decreased when it is combined with Efavirenz.
EfavirenzThe metabolism of Efavirenz can be decreased when combined with Sildenafil.
EfonidipineSildenafil may increase the antihypertensive activities of Efonidipine.
ElafinThe serum concentration of Sildenafil can be increased when it is combined with Elafin.
EletriptanThe metabolism of Eletriptan can be decreased when combined with Sildenafil.
EliglustatThe metabolism of Eliglustat can be decreased when combined with Sildenafil.
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Sildenafil.
EnalaprilThe serum concentration of Sildenafil can be increased when it is combined with Enalapril.
EnalaprilSildenafil may increase the antihypertensive activities of Enalapril.
EnalaprilatThe serum concentration of Sildenafil can be increased when it is combined with Enalaprilat.
EnalaprilatSildenafil may increase the antihypertensive activities of Enalaprilat.
EnalkirenThe serum concentration of Sildenafil can be increased when it is combined with Enalkiren.
EnzalutamideThe serum concentration of Sildenafil can be decreased when it is combined with Enzalutamide.
EnzalutamideThe metabolism of Enzalutamide can be decreased when combined with Sildenafil.
EpinastineThe metabolism of Epinastine can be decreased when combined with Sildenafil.
EplerenoneThe metabolism of Eplerenone can be decreased when combined with Sildenafil.
EpoprostenolSildenafil may increase the antihypertensive activities of Epoprostenol.
EprosartanSildenafil may increase the antihypertensive activities of Eprosartan.
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Sildenafil.
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Sildenafil.
ErgonovineThe metabolism of Ergonovine can be decreased when combined with Sildenafil.
ErgotamineThe metabolism of Ergotamine can be decreased when combined with Sildenafil.
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Sildenafil.
Erythrityl TetranitrateSildenafil may increase the vasodilatory activities of Erythrityl Tetranitrate.
ErythromycinThe metabolism of Sildenafil can be decreased when combined with Erythromycin.
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Sildenafil.
Eslicarbazepine acetateThe serum concentration of Sildenafil can be decreased when it is combined with Eslicarbazepine acetate.
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Sildenafil.
EstazolamThe metabolism of Estazolam can be decreased when combined with Sildenafil.
EstradiolThe metabolism of Estradiol can be decreased when combined with Sildenafil.
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Sildenafil.
EstramustineThe metabolism of Estramustine can be decreased when combined with Sildenafil.
EstroneThe metabolism of Estrone can be decreased when combined with Sildenafil.
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Sildenafil.
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Sildenafil.
EthanolEthanol may increase the hypotensive activities of Sildenafil.
EthanolThe metabolism of Ethanol can be decreased when combined with Sildenafil.
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Sildenafil.
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Sildenafil.
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Sildenafil.
EtodolacThe metabolism of Etodolac can be decreased when combined with Sildenafil.
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Sildenafil.
EtoposideThe metabolism of Etoposide can be decreased when combined with Sildenafil.
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Sildenafil.
EtravirineThe serum concentration of Sildenafil can be decreased when it is combined with Etravirine.
EtravirineThe metabolism of Etravirine can be decreased when combined with Sildenafil.
EverolimusThe metabolism of Everolimus can be decreased when combined with Sildenafil.
ExemestaneThe metabolism of Exemestane can be decreased when combined with Sildenafil.
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Sildenafil.
FelbamateThe metabolism of Felbamate can be decreased when combined with Sildenafil.
FelodipineSildenafil may increase the antihypertensive activities of Felodipine.
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Sildenafil.
FenoldopamSildenafil may increase the antihypertensive activities of Fenoldopam.
FentanylThe metabolism of Fentanyl can be decreased when combined with Sildenafil.
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Sildenafil.
FinasterideThe metabolism of Finasteride can be decreased when combined with Sildenafil.
FingolimodThe metabolism of Fingolimod can be decreased when combined with Sildenafil.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Sildenafil.
FloxuridineThe metabolism of Sildenafil can be decreased when combined with Floxuridine.
FluconazoleThe serum concentration of Sildenafil can be increased when it is combined with Fluconazole.
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Sildenafil.
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Sildenafil.
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Sildenafil.
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Sildenafil.
FluorouracilThe metabolism of Sildenafil can be decreased when combined with Fluorouracil.
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Sildenafil.
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Sildenafil.
FlurbiprofenThe metabolism of Flurbiprofen can be decreased when combined with Sildenafil.
FlutamideThe metabolism of Flutamide can be decreased when combined with Sildenafil.
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Sildenafil.
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be decreased when combined with Sildenafil.
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Sildenafil.
FluvoxamineThe metabolism of Sildenafil can be decreased when combined with Fluvoxamine.
FormoterolThe metabolism of Formoterol can be decreased when combined with Sildenafil.
FosamprenavirThe metabolism of Fosamprenavir can be decreased when combined with Sildenafil.
FosaprepitantThe serum concentration of Sildenafil can be increased when it is combined with Fosaprepitant.
FosinoprilThe serum concentration of Sildenafil can be increased when it is combined with Fosinopril.
FosinoprilSildenafil may increase the antihypertensive activities of Fosinopril.
FosphenytoinThe metabolism of Sildenafil can be increased when combined with Fosphenytoin.
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Sildenafil.
Fusidic AcidThe serum concentration of Sildenafil can be increased when it is combined with Fusidic Acid.
GalantamineThe metabolism of Galantamine can be decreased when combined with Sildenafil.
GavestinelThe metabolism of Gavestinel can be decreased when combined with Sildenafil.
GefitinibThe metabolism of Gefitinib can be decreased when combined with Sildenafil.
GeldanamycinThe serum concentration of Sildenafil can be increased when it is combined with Geldanamycin.
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Sildenafil.
GliclazideThe metabolism of Gliclazide can be decreased when combined with Sildenafil.
GlimepirideThe metabolism of Glimepiride can be decreased when combined with Sildenafil.
GlipizideThe metabolism of Glipizide can be decreased when combined with Sildenafil.
GlyburideThe metabolism of Glyburide can be decreased when combined with Sildenafil.
GM6001The serum concentration of Sildenafil can be increased when it is combined with GM6001.
GranisetronThe metabolism of Granisetron can be decreased when combined with Sildenafil.
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Sildenafil.
GuanabenzSildenafil may increase the antihypertensive activities of Guanabenz.
GuanadrelSildenafil may increase the antihypertensive activities of Guanadrel.
GuanethidineSildenafil may increase the antihypertensive activities of Guanethidine.
GuanfacineSildenafil may increase the antihypertensive activities of Guanfacine.
HalofantrineThe metabolism of Halofantrine can be decreased when combined with Sildenafil.
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Sildenafil.
HalothaneThe metabolism of Halothane can be decreased when combined with Sildenafil.
HexamethoniumSildenafil may increase the antihypertensive activities of Hexamethonium.
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Sildenafil.
HirulogThe serum concentration of Sildenafil can be increased when it is combined with Hirulog.
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Sildenafil.
HydralazineSildenafil may increase the antihypertensive activities of Hydralazine.
HydrochlorothiazideSildenafil may increase the antihypertensive activities of Hydrochlorothiazide.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Sildenafil.
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Sildenafil.
HydroflumethiazideSildenafil may increase the antihypertensive activities of Hydroflumethiazide.
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Sildenafil.
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Sildenafil.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Sildenafil.
IbuprofenThe metabolism of Ibuprofen can be decreased when combined with Sildenafil.
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Sildenafil.
IdelalisibThe serum concentration of Sildenafil can be increased when it is combined with Idelalisib.
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Sildenafil resulting in a loss in efficacy.
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Sildenafil.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Sildenafil.
ImatinibThe metabolism of Sildenafil can be decreased when combined with Imatinib.
ImipramineThe metabolism of Imipramine can be decreased when combined with Sildenafil.
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Sildenafil.
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Sildenafil.
IndapamideSildenafil may increase the antihypertensive activities of Indapamide.
IndenololSildenafil may increase the antihypertensive activities of Indenolol.
IndinavirThe metabolism of Indinavir can be decreased when combined with Sildenafil.
indisulamThe metabolism of indisulam can be decreased when combined with Sildenafil.
IndomethacinThe metabolism of Indomethacin can be decreased when combined with Sildenafil.
IndoraminSildenafil may increase the antihypertensive activities of Indoramin.
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Sildenafil.
IrbesartanSildenafil may increase the antihypertensive activities of Irbesartan.
IrbesartanThe metabolism of Sildenafil can be decreased when combined with Irbesartan.
IrinotecanThe metabolism of Irinotecan can be decreased when combined with Sildenafil.
IsavuconazoniumThe metabolism of Isavuconazonium can be decreased when combined with Sildenafil.
IsoflurophateThe serum concentration of Sildenafil can be increased when it is combined with Isoflurophate.
IsoniazidThe metabolism of Sildenafil can be decreased when combined with Isoniazid.
Isosorbide DinitrateSildenafil may increase the vasodilatory activities of Isosorbide Dinitrate.
Isosorbide MononitrateSildenafil may increase the vasodilatory activities of Isosorbide Mononitrate.
IsradipineSildenafil may increase the antihypertensive activities of Isradipine.
IsradipineThe metabolism of Sildenafil can be decreased when combined with Isradipine.
ItraconazoleThe serum concentration of Sildenafil can be increased when it is combined with Itraconazole.
ItraconazoleThe metabolism of Itraconazole can be decreased when combined with Sildenafil.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Sildenafil.
IvacaftorThe serum concentration of Sildenafil can be increased when it is combined with Ivacaftor.
IvacaftorThe metabolism of Ivacaftor can be decreased when combined with Sildenafil.
IvermectinThe metabolism of Ivermectin can be decreased when combined with Sildenafil.
IxabepiloneThe metabolism of Ixabepilone can be decreased when combined with Sildenafil.
IxazomibThe serum concentration of Sildenafil can be increased when it is combined with Ixazomib.
IxazomibThe metabolism of Ixazomib can be decreased when combined with Sildenafil.
KetamineThe metabolism of Ketamine can be decreased when combined with Sildenafil.
KetazolamThe metabolism of Ketazolam can be decreased when combined with Sildenafil.
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Sildenafil.
KetoconazoleThe metabolism of Ketoconazole can be decreased when combined with Sildenafil.
KetoprofenThe metabolism of Ketoprofen can be decreased when combined with Sildenafil.
LabetalolSildenafil may increase the antihypertensive activities of Labetalol.
LacidipineSildenafil may increase the antihypertensive activities of Lacidipine.
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Sildenafil.
LapatinibThe metabolism of Lapatinib can be decreased when combined with Sildenafil.
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Sildenafil.
LatanoprostSildenafil may increase the antihypertensive activities of Latanoprost.
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Sildenafil.
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Sildenafil.
LepirudinThe serum concentration of Sildenafil can be increased when it is combined with Lepirudin.
LercanidipineSildenafil may increase the antihypertensive activities of Lercanidipine.
LesinuradThe metabolism of Lesinurad can be decreased when combined with Sildenafil.
LetrozoleThe metabolism of Letrozole can be decreased when combined with Sildenafil.
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Sildenafil.
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Sildenafil.
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Sildenafil.
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Sildenafil.
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Sildenafil.
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Sildenafil.
LicofeloneThe metabolism of Licofelone can be decreased when combined with Sildenafil.
LidocaineThe metabolism of Lidocaine can be decreased when combined with Sildenafil.
LinagliptinThe serum concentration of Sildenafil can be increased when it is combined with Linagliptin.
LisinoprilThe serum concentration of Sildenafil can be increased when it is combined with Lisinopril.
LisinoprilSildenafil may increase the antihypertensive activities of Lisinopril.
LisurideThe metabolism of Lisuride can be decreased when combined with Sildenafil.
LofexidineSildenafil may increase the antihypertensive activities of Lofexidine.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Sildenafil.
LoperamideThe metabolism of Loperamide can be decreased when combined with Sildenafil.
LopinavirThe serum concentration of Sildenafil can be increased when it is combined with Lopinavir.
LopinavirThe metabolism of Lopinavir can be decreased when combined with Sildenafil.
LoratadineThe metabolism of Loratadine can be decreased when combined with Sildenafil.
LorcaserinThe risk or severity of adverse effects can be increased when Lorcaserin is combined with Sildenafil.
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Sildenafil.
LornoxicamThe metabolism of Lornoxicam can be decreased when combined with Sildenafil.
LosartanSildenafil may increase the antihypertensive activities of Losartan.
LosartanThe metabolism of Sildenafil can be decreased when combined with Losartan.
LovastatinThe metabolism of Sildenafil can be decreased when combined with Lovastatin.
LuliconazoleThe serum concentration of Sildenafil can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Sildenafil can be decreased when it is combined with Lumacaftor.
LumefantrineThe metabolism of Lumefantrine can be decreased when combined with Sildenafil.
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Sildenafil.
LurasidoneThe metabolism of Lurasidone can be decreased when combined with Sildenafil.
MacitentanSildenafil may increase the antihypertensive activities of Macitentan.
ManidipineSildenafil may increase the antihypertensive activities of Manidipine.
MaravirocThe metabolism of Maraviroc can be decreased when combined with Sildenafil.
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Sildenafil.
MecamylamineThe risk or severity of adverse effects can be increased when Sildenafil is combined with Mecamylamine.
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be decreased when combined with Sildenafil.
Mefenamic acidThe metabolism of Mefenamic acid can be decreased when combined with Sildenafil.
MefloquineThe metabolism of Mefloquine can be decreased when combined with Sildenafil.
MelatoninThe metabolism of Melatonin can be decreased when combined with Sildenafil.
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Sildenafil.
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Sildenafil.
MestranolThe metabolism of Mestranol can be decreased when combined with Sildenafil.
MethadoneThe metabolism of Methadone can be decreased when combined with Sildenafil.
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Sildenafil.
MethotrimeprazineThe metabolism of Sildenafil can be decreased when combined with Methotrimeprazine.
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Sildenafil.
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Sildenafil.
MethyldopaSildenafil may increase the antihypertensive activities of Methyldopa.
MethylprednisoloneThe metabolism of Methylprednisolone can be decreased when combined with Sildenafil.
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Sildenafil.
MetipranololSildenafil may increase the antihypertensive activities of Metipranolol.
MetolazoneSildenafil may increase the antihypertensive activities of Metolazone.
MetoprololSildenafil may increase the antihypertensive activities of Metoprolol.
MetoprololThe metabolism of Sildenafil can be decreased when combined with Metoprolol.
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Sildenafil.
MexiletineThe metabolism of Mexiletine can be decreased when combined with Sildenafil.
MianserinThe metabolism of Mianserin can be decreased when combined with Sildenafil.
MibefradilSildenafil may increase the antihypertensive activities of Mibefradil.
MiconazoleThe metabolism of Miconazole can be decreased when combined with Sildenafil.
MidazolamThe metabolism of Midazolam can be decreased when combined with Sildenafil.
MifepristoneThe metabolism of Mifepristone can be decreased when combined with Sildenafil.
MinoxidilSildenafil may increase the antihypertensive activities of Minoxidil.
MirabegronThe metabolism of Mirabegron can be decreased when combined with Sildenafil.
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Sildenafil.
MitotaneThe serum concentration of Sildenafil can be decreased when it is combined with Mitotane.
MoclobemideThe metabolism of Sildenafil can be decreased when combined with Moclobemide.
ModafinilThe serum concentration of Sildenafil can be decreased when it is combined with Modafinil.
ModafinilThe metabolism of Modafinil can be decreased when combined with Sildenafil.
MoexiprilThe serum concentration of Sildenafil can be increased when it is combined with Moexipril.
MoexiprilSildenafil may increase the antihypertensive activities of Moexipril.
MolsidomineMolsidomine may increase the hypotensive activities of Sildenafil.
MontelukastThe metabolism of Montelukast can be decreased when combined with Sildenafil.
MorphineThe metabolism of Morphine can be decreased when combined with Sildenafil.
MoxonidineSildenafil may increase the antihypertensive activities of Moxonidine.
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Sildenafil.
N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-ProlineThe serum concentration of Sildenafil can be increased when it is combined with N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline.
NadololSildenafil may increase the antihypertensive activities of Nadolol.
NafcillinThe serum concentration of Sildenafil can be decreased when it is combined with Nafcillin.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Sildenafil.
NaloxoneThe metabolism of Naloxone can be decreased when combined with Sildenafil.
NaproxenThe metabolism of Naproxen can be decreased when combined with Sildenafil.
NateglinideThe metabolism of Nateglinide can be decreased when combined with Sildenafil.
NCX 4016The serum concentration of Sildenafil can be increased when it is combined with NCX 4016.
NebivololSildenafil may increase the antihypertensive activities of Nebivolol.
NefazodoneThe serum concentration of Sildenafil can be increased when it is combined with Nefazodone.
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Sildenafil.
NelfinavirThe metabolism of Nelfinavir can be decreased when combined with Sildenafil.
NetupitantThe serum concentration of Sildenafil can be increased when it is combined with Netupitant.
NetupitantThe metabolism of Netupitant can be decreased when combined with Sildenafil.
NevirapineThe metabolism of Sildenafil can be decreased when combined with Nevirapine.
NicardipineSildenafil may increase the antihypertensive activities of Nicardipine.
NicardipineThe metabolism of Sildenafil can be decreased when combined with Nicardipine.
NiclosamideThe metabolism of Niclosamide can be decreased when combined with Sildenafil.
NicorandilSildenafil may increase the antihypertensive activities of Nicorandil.
NicotineThe metabolism of Nicotine can be decreased when combined with Sildenafil.
NifedipineThe metabolism of Nifedipine can be decreased when combined with Sildenafil.
NiguldipineSildenafil may increase the antihypertensive activities of Niguldipine.
NilotinibThe metabolism of Nilotinib can be decreased when combined with Sildenafil.
NilvadipineSildenafil may increase the antihypertensive activities of Nilvadipine.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Sildenafil.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Sildenafil.
NisoldipineSildenafil may increase the antihypertensive activities of Nisoldipine.
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Sildenafil.
NitrendipineSildenafil may increase the antihypertensive activities of Nitrendipine.
NitroglycerinSildenafil may increase the vasodilatory activities of Nitroglycerin.
NitroprussideSildenafil may increase the antihypertensive activities of Nitroprusside.
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Sildenafil.
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Sildenafil.
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Sildenafil.
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Sildenafil.
OlaparibThe metabolism of Sildenafil can be decreased when combined with Olaparib.
OlmesartanSildenafil may increase the antihypertensive activities of Olmesartan.
OlodaterolThe metabolism of Olodaterol can be decreased when combined with Sildenafil.
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Sildenafil.
OmapatrilatThe serum concentration of Sildenafil can be increased when it is combined with Omapatrilat.
OmapatrilatSildenafil may increase the antihypertensive activities of Omapatrilat.
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Sildenafil.
OndansetronThe metabolism of Ondansetron can be decreased when combined with Sildenafil.
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Sildenafil.
OsimertinibThe serum concentration of Sildenafil can be increased when it is combined with Osimertinib.
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Sildenafil.
OtamixabanThe serum concentration of Sildenafil can be increased when it is combined with Otamixaban.
OxaprozinThe metabolism of Oxaprozin can be decreased when combined with Sildenafil.
OxazepamThe metabolism of Oxazepam can be decreased when combined with Sildenafil.
OxprenololSildenafil may increase the antihypertensive activities of Oxprenolol.
OxybutyninThe metabolism of Oxybutynin can be decreased when combined with Sildenafil.
OxycodoneThe metabolism of Oxycodone can be decreased when combined with Sildenafil.
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Sildenafil.
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Sildenafil.
PalbociclibThe serum concentration of Sildenafil can be increased when it is combined with Palbociclib.
PalbociclibThe metabolism of Palbociclib can be decreased when combined with Sildenafil.
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Sildenafil.
PanobinostatThe metabolism of Panobinostat can be decreased when combined with Sildenafil.
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Sildenafil.
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Sildenafil.
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Sildenafil.
ParecoxibThe metabolism of Parecoxib can be decreased when combined with Sildenafil.
PargylineSildenafil may increase the antihypertensive activities of Pargyline.
ParicalcitolThe metabolism of Paricalcitol can be decreased when combined with Sildenafil.
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Sildenafil.
ParoxetineThe metabolism of Sildenafil can be decreased when combined with Paroxetine.
PazopanibThe metabolism of Pazopanib can be decreased when combined with Sildenafil.
Peginterferon alfa-2bThe serum concentration of Sildenafil can be decreased when it is combined with Peginterferon alfa-2b.
PenbutololSildenafil may increase the antihypertensive activities of Penbutolol.
PentamidineThe metabolism of Pentamidine can be decreased when combined with Sildenafil.
PentobarbitalThe metabolism of Sildenafil can be increased when combined with Pentobarbital.
PentoliniumSildenafil may increase the antihypertensive activities of Pentolinium.
PerampanelThe metabolism of Perampanel can be decreased when combined with Sildenafil.
PergolideThe metabolism of Pergolide can be decreased when combined with Sildenafil.
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Sildenafil.
PerindoprilThe serum concentration of Sildenafil can be increased when it is combined with Perindopril.
PerindoprilSildenafil may increase the antihypertensive activities of Perindopril.
PermethrinThe metabolism of Permethrin can be decreased when combined with Sildenafil.
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Sildenafil.
PethidineThe metabolism of Pethidine can be decreased when combined with Sildenafil.
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Sildenafil.
PhenobarbitalThe metabolism of Sildenafil can be increased when combined with Phenobarbital.
PhenoxybenzamineSildenafil may increase the antihypertensive activities of Phenoxybenzamine.
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Sildenafil.
PhentolamineSildenafil may increase the antihypertensive activities of Phentolamine.
PhenylbutazoneThe metabolism of Phenylbutazone can be decreased when combined with Sildenafil.
PhenytoinThe metabolism of Sildenafil can be increased when combined with Phenytoin.
PhosphoramidonThe serum concentration of Sildenafil can be increased when it is combined with Phosphoramidon.
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Sildenafil.
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Sildenafil.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Sildenafil.
PinacidilSildenafil may increase the antihypertensive activities of Pinacidil.
PindololSildenafil may increase the antihypertensive activities of Pindolol.
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Sildenafil.
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Sildenafil.
PiroxicamThe metabolism of Piroxicam can be decreased when combined with Sildenafil.
PitavastatinThe metabolism of Pitavastatin can be decreased when combined with Sildenafil.
PodofiloxThe metabolism of Podofilox can be decreased when combined with Sildenafil.
PolythiazideSildenafil may increase the antihypertensive activities of Polythiazide.
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Sildenafil.
PonatinibThe metabolism of Ponatinib can be decreased when combined with Sildenafil.
PosaconazoleThe serum concentration of Sildenafil can be increased when it is combined with Posaconazole.
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Sildenafil.
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Sildenafil.
PravastatinThe metabolism of Pravastatin can be decreased when combined with Sildenafil.
PrazepamThe metabolism of Prazepam can be decreased when combined with Sildenafil.
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Sildenafil.
PrazosinSildenafil may increase the antihypertensive activities of Prazosin.
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Sildenafil.
PrednisoneThe metabolism of Prednisone can be decreased when combined with Sildenafil.
PrimaquineThe metabolism of Primaquine can be decreased when combined with Sildenafil.
PrimidoneThe metabolism of Sildenafil can be increased when combined with Primidone.
PrinomastatThe serum concentration of Sildenafil can be increased when it is combined with Prinomastat.
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Sildenafil.
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Sildenafil.
ProguanilThe metabolism of Proguanil can be decreased when combined with Sildenafil.
PromazineThe metabolism of Promazine can be decreased when combined with Sildenafil.
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Sildenafil.
PropofolThe metabolism of Propofol can be decreased when combined with Sildenafil.
PropranololSildenafil may increase the antihypertensive activities of Propranolol.
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Sildenafil.
PyrimethamineThe metabolism of Sildenafil can be decreased when combined with Pyrimethamine.
QuazepamThe metabolism of Quazepam can be decreased when combined with Sildenafil.
QuetiapineThe metabolism of Quetiapine can be decreased when combined with Sildenafil.
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Sildenafil.
QuinaprilThe serum concentration of Sildenafil can be increased when it is combined with Quinapril.
QuinaprilSildenafil may increase the antihypertensive activities of Quinapril.
QuinidineThe metabolism of Quinidine can be decreased when combined with Sildenafil.
QuinineThe metabolism of Quinine can be decreased when combined with Sildenafil.
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Sildenafil.
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Sildenafil.
RamelteonThe metabolism of Ramelteon can be decreased when combined with Sildenafil.
RamiprilThe serum concentration of Sildenafil can be increased when it is combined with Ramipril.
RamiprilSildenafil may increase the antihypertensive activities of Ramipril.
RanolazineThe metabolism of Sildenafil can be decreased when combined with Ranolazine.
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Sildenafil.
RegorafenibThe metabolism of Regorafenib can be decreased when combined with Sildenafil.
RemikirenThe serum concentration of Sildenafil can be increased when it is combined with Remikiren.
RemikirenSildenafil may increase the antihypertensive activities of Remikiren.
RepaglinideThe metabolism of Repaglinide can be decreased when combined with Sildenafil.
RescinnamineSildenafil may increase the antihypertensive activities of Rescinnamine.
ReserpineSildenafil may increase the antihypertensive activities of Reserpine.
RetapamulinThe metabolism of Retapamulin can be decreased when combined with Sildenafil.
RifabutinThe metabolism of Sildenafil can be increased when combined with Rifabutin.
RifampicinThe metabolism of Sildenafil can be increased when combined with Rifampicin.
RifapentineThe metabolism of Sildenafil can be increased when combined with Rifapentine.
RilpivirineThe metabolism of Rilpivirine can be decreased when combined with Sildenafil.
RimonabantThe metabolism of Rimonabant can be decreased when combined with Sildenafil.
RiociguatSildenafil may increase the hypotensive activities of Riociguat.
RisperidoneThe metabolism of Risperidone can be decreased when combined with Sildenafil.
RitonavirThe serum concentration of Sildenafil can be increased when it is combined with Ritonavir.
RitonavirThe metabolism of Ritonavir can be decreased when combined with Sildenafil.
RivaroxabanThe serum concentration of Sildenafil can be increased when it is combined with Rivaroxaban.
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Sildenafil.
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Sildenafil.
RolapitantThe metabolism of Rolapitant can be decreased when combined with Sildenafil.
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Sildenafil.
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Sildenafil.
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Sildenafil.
RosiglitazoneThe metabolism of Rosiglitazone can be decreased when combined with Sildenafil.
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Sildenafil.
RotigotineThe metabolism of Rotigotine can be decreased when combined with Sildenafil.
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Sildenafil.
RuxolitinibThe metabolism of Ruxolitinib can be decreased when combined with Sildenafil.
Salicylic acidThe metabolism of Salicylic acid can be decreased when combined with Sildenafil.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Sildenafil.
SaprisartanSildenafil may increase the antihypertensive activities of Saprisartan.
SapropterinSapropterin may increase the hypotensive activities of Sildenafil.
SaquinavirThe serum concentration of Sildenafil can be increased when it is combined with Saquinavir.
SaquinavirThe metabolism of Saquinavir can be decreased when combined with Sildenafil.
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Sildenafil.
SecobarbitalThe metabolism of Sildenafil can be increased when combined with Secobarbital.
SelegilineThe metabolism of Selegiline can be decreased when combined with Sildenafil.
SelexipagSildenafil may increase the antihypertensive activities of Selexipag.
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Sildenafil.
SertindoleThe metabolism of Sertindole can be decreased when combined with Sildenafil.
SertralineThe metabolism of Sertraline can be decreased when combined with Sildenafil.
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Sildenafil.
SibutramineThe metabolism of Sibutramine can be decreased when combined with Sildenafil.
SilodosinThe metabolism of Silodosin can be decreased when combined with Sildenafil.
SiltuximabThe serum concentration of Sildenafil can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Sildenafil can be increased when it is combined with Simeprevir.
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Sildenafil.
SirolimusThe metabolism of Sirolimus can be decreased when combined with Sildenafil.
SitagliptinThe serum concentration of Sildenafil can be increased when it is combined with Sitagliptin.
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Sildenafil.
SitaxentanSildenafil may increase the antihypertensive activities of Sitaxentan.
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Sildenafil.
SonidegibThe metabolism of Sonidegib can be decreased when combined with Sildenafil.
SorafenibThe metabolism of Sorafenib can be decreased when combined with Sildenafil.
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Sildenafil.
SpiraprilThe serum concentration of Sildenafil can be increased when it is combined with Spirapril.
SpiraprilSildenafil may increase the antihypertensive activities of Spirapril.
St. John's WortThe serum concentration of Sildenafil can be decreased when it is combined with St. John's Wort.
StiripentolThe serum concentration of Sildenafil can be increased when it is combined with Stiripentol.
SufentanilThe metabolism of Sufentanil can be decreased when combined with Sildenafil.
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Sildenafil.
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Sildenafil.
SulfamoxoleThe metabolism of Sulfamoxole can be decreased when combined with Sildenafil.
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Sildenafil.
SulfisoxazoleThe metabolism of Sildenafil can be decreased when combined with Sulfisoxazole.
SunitinibThe metabolism of Sunitinib can be decreased when combined with Sildenafil.
SuprofenThe metabolism of Suprofen can be decreased when combined with Sildenafil.
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Sildenafil.
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Sildenafil.
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Sildenafil.
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Sildenafil.
TadalafilThe risk or severity of adverse effects can be increased when Sildenafil is combined with Tadalafil.
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Sildenafil.
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Sildenafil.
TapentadolThe metabolism of Tapentadol can be decreased when combined with Sildenafil.
TasosartanThe metabolism of Tasosartan can be decreased when combined with Sildenafil.
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Sildenafil.
TelaprevirThe serum concentration of Sildenafil can be increased when it is combined with Telaprevir.
TelaprevirThe metabolism of Telaprevir can be decreased when combined with Sildenafil.
TelithromycinThe serum concentration of Sildenafil can be increased when it is combined with Telithromycin.
TelithromycinThe metabolism of Telithromycin can be decreased when combined with Sildenafil.
TelmisartanSildenafil may increase the antihypertensive activities of Telmisartan.
TemazepamThe metabolism of Temazepam can be decreased when combined with Sildenafil.
TemocaprilThe serum concentration of Sildenafil can be increased when it is combined with Temocapril.
TemocaprilSildenafil may increase the antihypertensive activities of Temocapril.
TemsirolimusThe metabolism of Temsirolimus can be decreased when combined with Sildenafil.
TeniposideThe metabolism of Teniposide can be decreased when combined with Sildenafil.
TenoxicamThe metabolism of Tenoxicam can be decreased when combined with Sildenafil.
TerazosinSildenafil may increase the hypotensive activities of Terazosin.
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Sildenafil.
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Sildenafil.
TerlipressinSildenafil may increase the antihypertensive activities of Terlipressin.
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Sildenafil.
TestosteroneThe metabolism of Testosterone can be decreased when combined with Sildenafil.
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Sildenafil.
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Sildenafil.
TheophyllineThe metabolism of Theophylline can be decreased when combined with Sildenafil.
ThiamylalThe metabolism of Thiamylal can be decreased when combined with Sildenafil.
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Sildenafil.
ThioridazineThe metabolism of Sildenafil can be decreased when combined with Thioridazine.
ThiorphanThe serum concentration of Sildenafil can be increased when it is combined with Thiorphan.
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Sildenafil.
TiagabineThe metabolism of Tiagabine can be decreased when combined with Sildenafil.
TiboloneSildenafil may increase the antihypertensive activities of Tibolone.
TicagrelorThe metabolism of Ticagrelor can be decreased when combined with Sildenafil.
TiclopidineThe metabolism of Sildenafil can be decreased when combined with Ticlopidine.
TicrynafenSildenafil may increase the antihypertensive activities of Ticrynafen.
TimololSildenafil may increase the antihypertensive activities of Timolol.
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Sildenafil.
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Sildenafil.
TipranavirThe serum concentration of Sildenafil can be increased when it is combined with Tipranavir.
TipranavirThe metabolism of Tipranavir can be decreased when combined with Sildenafil.
TocilizumabThe serum concentration of Sildenafil can be decreased when it is combined with Tocilizumab.
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Sildenafil.
TolazolineSildenafil may increase the antihypertensive activities of Tolazoline.
TolbutamideThe metabolism of Tolbutamide can be decreased when combined with Sildenafil.
TolterodineThe metabolism of Tolterodine can be decreased when combined with Sildenafil.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Sildenafil.
TopiramateThe metabolism of Sildenafil can be decreased when combined with Topiramate.
TorasemideSildenafil may increase the antihypertensive activities of Torasemide.
ToremifeneThe metabolism of Toremifene can be decreased when combined with Sildenafil.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Sildenafil.
TramadolThe metabolism of Tramadol can be decreased when combined with Sildenafil.
TrandolaprilThe serum concentration of Sildenafil can be increased when it is combined with Trandolapril.
TrandolaprilSildenafil may increase the antihypertensive activities of Trandolapril.
TranylcypromineThe metabolism of Sildenafil can be decreased when combined with Tranylcypromine.
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be decreased when combined with Sildenafil.
TravoprostSildenafil may increase the antihypertensive activities of Travoprost.
TrazodoneThe metabolism of Trazodone can be decreased when combined with Sildenafil.
TreprostinilSildenafil may increase the antihypertensive activities of Treprostinil.
TretinoinThe metabolism of Tretinoin can be decreased when combined with Sildenafil.
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Sildenafil.
TriazolamThe metabolism of Triazolam can be decreased when combined with Sildenafil.
TrichlormethiazideSildenafil may increase the antihypertensive activities of Trichlormethiazide.
TrimazosinSildenafil may increase the antihypertensive activities of Trimazosin.
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Sildenafil.
TrimethaphanSildenafil may increase the antihypertensive activities of Trimethaphan.
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Sildenafil.
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Sildenafil.
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Sildenafil.
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Sildenafil.
UbenimexThe serum concentration of Sildenafil can be increased when it is combined with Ubenimex.
UdenafilThe risk or severity of adverse effects can be increased when Sildenafil is combined with Udenafil.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Sildenafil.
UnoprostoneSildenafil may increase the antihypertensive activities of Unoprostone.
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Sildenafil.
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Sildenafil.
ValsartanSildenafil may increase the antihypertensive activities of Valsartan.
ValsartanThe metabolism of Sildenafil can be decreased when combined with Valsartan.
VandetanibThe metabolism of Vandetanib can be decreased when combined with Sildenafil.
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Sildenafil.
VardenafilThe risk or severity of adverse effects can be increased when Sildenafil is combined with Vardenafil.
VemurafenibThe metabolism of Vemurafenib can be decreased when combined with Sildenafil.
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Sildenafil.
VerapamilThe metabolism of Verapamil can be decreased when combined with Sildenafil.
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Sildenafil.
VilanterolThe metabolism of Vilanterol can be decreased when combined with Sildenafil.
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Sildenafil.
VildagliptinThe serum concentration of Sildenafil can be increased when it is combined with Vildagliptin.
VinblastineThe metabolism of Vinblastine can be decreased when combined with Sildenafil.
VincristineThe metabolism of Vincristine can be decreased when combined with Sildenafil.
VindesineThe serum concentration of Vindesine can be increased when it is combined with Sildenafil.
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Sildenafil.
VismodegibThe metabolism of Vismodegib can be decreased when combined with Sildenafil.
VoriconazoleThe metabolism of Voriconazole can be decreased when combined with Sildenafil.
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Sildenafil.
WarfarinThe metabolism of Warfarin can be decreased when combined with Sildenafil.
XimelagatranThe serum concentration of Sildenafil can be increased when it is combined with Ximelagatran.
XimelagatranThe metabolism of Ximelagatran can be decreased when combined with Sildenafil.
XylometazolineSildenafil may increase the antihypertensive activities of Xylometazoline.
YohimbineThe metabolism of Yohimbine can be decreased when combined with Sildenafil.
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Sildenafil.
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Sildenafil.
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Sildenafil.
ZaltoprofenThe metabolism of Zaltoprofen can be decreased when combined with Sildenafil.
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Sildenafil.
ZileutonThe metabolism of Zileuton can be decreased when combined with Sildenafil.
ZiprasidoneThe metabolism of Sildenafil can be decreased when combined with Ziprasidone.
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Sildenafil.
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Sildenafil.
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Sildenafil.
ZopicloneThe metabolism of Zopiclone can be decreased when combined with Sildenafil.
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Sildenafil.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Metal ion binding
Specific Function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:9714779, PubMed:15489334). Specifically regulates nitric-oxide-generated cGMP (PubMed:15489334).
Gene Name:
PDE5A
Uniprot ID:
O76074
Molecular Weight:
99984.14 Da
References
  1. Carson CC: Long-term use of sildenafil. Expert Opin Pharmacother. 2003 Mar;4(3):397-405. [PubMed:12614192 ]
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  3. Corbin JD, Francis SH, Webb DJ: Phosphodiesterase type 5 as a pharmacologic target in erectile dysfunction. Urology. 2002 Sep;60(2 Suppl 2):4-11. [PubMed:12414329 ]
  4. Kruuse C, Thomsen LL, Birk S, Olesen J: Migraine can be induced by sildenafil without changes in middle cerebral artery diameter. Brain. 2003 Jan;126(Pt 1):241-7. [PubMed:12477710 ]
  5. Rybalkin SD, Rybalkina IG, Shimizu-Albergine M, Tang XB, Beavo JA: PDE5 is converted to an activated state upon cGMP binding to the GAF A domain. EMBO J. 2003 Feb 3;22(3):469-78. [PubMed:12554648 ]
  6. Wang H, Liu Y, Huai Q, Cai J, Zoraghi R, Francis SH, Corbin JD, Robinson H, Xin Z, Lin G, Ke H: Multiple conformations of phosphodiesterase-5: implications for enzyme function and drug development. J Biol Chem. 2006 Jul 28;281(30):21469-79. Epub 2006 May 30. [PubMed:16735511 ]
  7. Wang H, Ye M, Robinson H, Francis SH, Ke H: Conformational variations of both phosphodiesterase-5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil. Mol Pharmacol. 2008 Jan;73(1):104-10. Epub 2007 Oct 24. [PubMed:17959709 ]
  8. Wang J, Re J, Wang Z: [Mode of action of sildenafil]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1999 Dec;21(6):493-6. [PubMed:12567500 ]
  9. Zoraghi R, Francis SH, Corbin JD: Critical amino acids in phosphodiesterase-5 catalytic site that provide for high-affinity interaction with cyclic guanosine monophosphate and inhibitors. Biochemistry. 2007 Nov 27;46(47):13554-63. Epub 2007 Nov 3. [PubMed:17979301 ]
Kind
Protein
Organism
Human
Pharmacological action
no
Actions
inhibitor
General Function:
Enzyme inhibitor activity
Specific Function:
Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
Gene Name:
PDE6G
Uniprot ID:
P18545
Molecular Weight:
9643.09 Da
References
  1. Uckert S, Hedlund P, Andersson KE, Truss MC, Jonas U, Stief CG: Update on phosphodiesterase (PDE) isoenzymes as pharmacologic targets in urology: present and future. Eur Urol. 2006 Dec;50(6):1194-207; discussion 1207. Epub 2006 Jun 6. [PubMed:16815627 ]
Kind
Protein
Organism
Human
Pharmacological action
no
Actions
inhibitor
General Function:
Enzyme inhibitor activity
Specific Function:
Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
Gene Name:
PDE6H
Uniprot ID:
Q13956
Molecular Weight:
9074.36 Da
References
  1. Uckert S, Hedlund P, Andersson KE, Truss MC, Jonas U, Stief CG: Update on phosphodiesterase (PDE) isoenzymes as pharmacologic targets in urology: present and future. Eur Urol. 2006 Dec;50(6):1194-207; discussion 1207. Epub 2006 Jun 6. [PubMed:16815627 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Ku HY, Ahn HJ, Seo KA, Kim H, Oh M, Bae SK, Shin JG, Shon JH, Liu KH: The contributions of cytochromes P450 3A4 and 3A5 to the metabolism of the phosphodiesterase type 5 inhibitors sildenafil, udenafil, and vardenafil. Drug Metab Dispos. 2008 Jun;36(6):986-90. doi: 10.1124/dmd.107.020099. Epub 2008 Feb 28. [PubMed:18308836 ]
  2. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  4. Hyland R, Roe EG, Jones BC, Smith DA: Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil. Br J Clin Pharmacol. 2001 Mar;51(3):239-48. [PubMed:11298070 ]
  5. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Ku HY, Ahn HJ, Seo KA, Kim H, Oh M, Bae SK, Shin JG, Shon JH, Liu KH: The contributions of cytochromes P450 3A4 and 3A5 to the metabolism of the phosphodiesterase type 5 inhibitors sildenafil, udenafil, and vardenafil. Drug Metab Dispos. 2008 Jun;36(6):986-90. doi: 10.1124/dmd.107.020099. Epub 2008 Feb 28. [PubMed:18308836 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Hyland R, Roe EG, Jones BC, Smith DA: Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil. Br J Clin Pharmacol. 2001 Mar;51(3):239-48. [PubMed:11298070 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Vitamin d 24-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP1A1
Uniprot ID:
P04798
Molecular Weight:
58164.815 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular Weight:
56848.42 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Atpase activity, coupled to transmembrane movement of substances
Specific Function:
May be an organic anion pump relevant to cellular detoxification.
Gene Name:
ABCC4
Uniprot ID:
O15439
Molecular Weight:
149525.33 Da
References
  1. Chen ZS, Lee K, Walther S, Raftogianis RB, Kuwano M, Zeng H, Kruh GD: Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res. 2002 Jun 1;62(11):3144-50. [PubMed:12036927 ]
  2. Reid G, Wielinga P, Zelcer N, De Haas M, Van Deemter L, Wijnholds J, Balzarini J, Borst P: Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. Mol Pharmacol. 2003 May;63(5):1094-103. [PubMed:12695538 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Organic anion transmembrane transporter activity
Specific Function:
Acts as a multispecific organic anion pump which can transport nucleotide analogs.
Gene Name:
ABCC5
Uniprot ID:
O15440
Molecular Weight:
160658.8 Da
References
  1. Jedlitschky G, Burchell B, Keppler D: The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. J Biol Chem. 2000 Sep 29;275(39):30069-74. [PubMed:10893247 ]
  2. Reid G, Wielinga P, Zelcer N, De Haas M, Van Deemter L, Wijnholds J, Balzarini J, Borst P: Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. Mol Pharmacol. 2003 May;63(5):1094-103. [PubMed:12695538 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Atpase activity, coupled to transmembrane movement of substances
Specific Function:
ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion.
Gene Name:
ABCC10
Uniprot ID:
Q5T3U5
Molecular Weight:
161627.375 Da
References
  1. Chen ZS, Hopper-Borge E, Belinsky MG, Shchaveleva I, Kotova E, Kruh GD: Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). Mol Pharmacol. 2003 Feb;63(2):351-8. [PubMed:12527806 ]
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Drug created on June 13, 2005 07:24 / Updated on September 25, 2016 03:31