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Identification
NamePantoprazole
Accession NumberDB00213  (APRD00073)
TypeSmall Molecule
GroupsApproved
Description

Pantoprazole is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.

Structure
Thumb
Synonyms
SynonymLanguageCode
PantoprazolSpanishINN
PantoprazolumLatinINN
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Protonix I.V.injection, powder, for solution40 mg/10mLintravenousWyeth Pharmaceuticals Inc., a subsidiary of Pfizer Inc.2001-05-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Protonixtablet, delayed release40 mgoralRebel Distributors Corp2001-08-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoloctablet (enteric-coated)40 mgoralTakeda Canada IncNot AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Pantoloctablet (enteric-coated)20 mgoralTakeda Canada IncNot AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Tectatablet (enteric-coated)40 mgoralTakeda Canada IncNot AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Pantoprazole Sodiumtablet, delayed release20 mgoralTeva Pharmaceuticals USA Inc2007-12-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralTeva Pharmaceuticals USA Inc2007-12-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralMylan Pharmaceuticals Inc.2011-01-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralMylan Pharmaceuticals Inc.2011-01-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-01-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazoletablet, delayed release40 mgoralMajor Pharmaceuticals2011-01-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralTorrent Pharmaceuticals Limited2011-01-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralTorrent Pharmaceuticals Limited2011-01-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiuminjection, powder, for solution40 mgintravenousAkorn, Inc.2012-11-08Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralRebel Distributors Corp2010-10-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralCamber Pharmaceuticals, Inc.2014-09-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralCamber Pharmaceuticals, Inc.2014-09-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralMacleods Pharmaceuticals Limited2011-12-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralMacleods Pharmaceuticals Limited2011-12-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralRx Change Co.2007-12-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralLake Erie Medical DBA Quality Care Products LLC2011-01-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralRebel Distributors Corp2007-09-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralAphena Pharma Solutions Tennessee, Inc.2011-01-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralActavis Inc.2011-02-08Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralActavis Inc.2011-02-08Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralSun Pharma Global FZE2007-09-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralSun Pharma Global FZE2007-09-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralSafecor Health, LLC2014-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralREMEDYREPACK INC.2011-11-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet40 mgoralREMEDYREPACK INC.2011-11-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet40 mgoralREMEDYREPACK INC.2014-01-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralREMEDYREPACK INC.2011-12-02Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralREMEDYREPACK INC.2013-02-08Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralAv Pak2013-01-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralAv Pak2013-01-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralUnit Dose Services2007-09-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralUnit Dose Services2011-01-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralMylan Institutional Inc.2012-09-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralREMEDYREPACK INC.2013-05-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralREMEDYREPACK INC.2013-05-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralREMEDYREPACK INC.2013-10-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralREMEDYREPACK INC.2014-02-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralREMEDYREPACK INC.2014-02-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralREMEDYREPACK INC.2014-04-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralREMEDYREPACK INC.2014-06-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralState of Florida DOH Central Pharmacy2014-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralState of Florida DOH Central Pharmacy2014-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralState of Florida DOH Central Pharmacy2014-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazoletablet, delayed release40 mgoralState of Florida DOH Central Pharmacy2014-11-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralState of Florida DOH Central Pharmacy2014-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralState of Florida DOH Central Pharmacy2014-11-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazoletablet, delayed release20 mgoralState of Florida DOH Central Pharmacy2014-11-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralPhysicians Total Care, Inc.2008-01-02Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralPhysicians Total Care, Inc.2009-06-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazoletablet, delayed release20 mgoralDr.Reddy's Laboratories Limited2011-01-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazoletablet, delayed release40 mgoralDr.Reddy's Laboratories Limited2011-01-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralCardinal Health2011-02-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazoletablet, delayed release40 mgoralCardinal Health2011-01-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralCardinal Health2013-01-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralCardinal Health2012-09-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralCardinal Health2012-01-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralWockhardt Limited2011-01-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralWockhardt Limited2011-01-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralLake Erie Medical DBA Quality Care Products LLC2013-04-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralClinical Solutions Wholesale2011-02-08Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralJubilant Cadista Pharmaceuticals Inc.2011-09-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralJubilant Cadista Pharmaceuticals Inc.2011-09-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralSt Marys Medical Park Pharmacy2013-08-08Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralREMEDYREPACK INC.2014-12-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralREMEDYREPACK INC.2015-01-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralDIRECT RX2014-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralDIRECT RX2014-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralKremers Urban Pharmaceuticals Inc.2011-01-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralKremers Urban Pharmaceuticals Inc.2011-01-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralKremers Urban Pharmaceuticals Inc.2011-01-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralSun Pharmaceutical Industries Limited2014-12-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralSun Pharmaceutical Industries Limited2014-12-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralProficient Rx LP2011-02-08Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralProficient Rx LP2007-12-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralbryant ranch prepack2007-12-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralbryant ranch prepack2011-01-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2011-01-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralReady Meds2011-01-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralWockhardt USA LLC.2011-01-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralWockhardt USA LLC.2011-01-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralAurobindo Pharma Limited2012-09-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralAurobindo Pharma Limited2012-09-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralAmerican Health Packaging2013-05-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralAmerican Health Packaging2013-05-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralAmerican Health Packaging2011-02-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralAmerican Health Packaging2012-03-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralAmerican Health Packaging2013-08-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralAmerican Health Packaging2013-08-262015-08-31Us 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralAmerican Health Packaging2014-12-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazoletablet, delayed release40 mgoralLegacy Pharmaceutical Packaging2011-01-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralLegacy Pharmaceutical Packaging2011-01-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralLegacy Pharmaceutical Packaging2011-01-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralLegacy Pharmaceutical Packaging2011-01-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralLegacy Pharmaceutical Packaging2011-01-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release40 mgoralPreferred Pharmaceuticals, Inc.2014-12-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralPreferred Pharmaceuticals, Inc.2014-12-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralPreferred Pharmaceuticals, Inc.2011-01-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralPreferred Pharmaceuticals, Inc.2014-02-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralPreferred Pharmaceuticals, Inc.2014-03-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralPreferred Pharmaceuticals, Inc.2013-11-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazole Sodiumtablet, delayed release20 mgoralPreferred Pharmaceuticals, Inc.2013-08-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Pantoprazoletablet (delayed-release)40 mgoralPro Doc LimiteeNot AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Pantoprazoletablet (delayed-release)40 mgoralSanis Health IncNot AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Pantoprazoletablet (delayed-release)20 mgoralSivem Pharmaceuticals UlcNot AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Pantoprazoletablet (delayed-release)40 mgoralSivem Pharmaceuticals UlcNot AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Pantoprazoletablet (delayed-release)40 mgoralLaboratoire Riva IncNot AvailableNot AvailableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Over the Counter ProductsNot Available
International Brands
NameCompany
PantozolNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Pantoprazole Magnesium
ThumbNot applicableDBSALT000853
Pantoprazole Sodium
138786-67-1
Thumb
  • InChI Key: YNWDKZIIWCEDEE-UHFFFAOYNA-N
  • Monoisotopic Mass: 405.057077726
  • Average Mass: 405.352
DBSALT000386
Categories
CAS number102625-70-7
WeightAverage: 383.37
Monoisotopic: 383.075133083
Chemical FormulaC16H15F2N3O4S
InChI KeyIQPSEEYGBUAQFF-UHFFFAOYSA-N
InChI
InChI=1S/C16H15F2N3O4S/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16/h3-7,15H,8H2,1-2H3,(H,20,21)
IUPAC Name
6-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methanesulfinyl]-1H-1,3-benzodiazole
SMILES
COC1=C(OC)C(CS(=O)C2=NC3=C(N2)C=C(OC(F)F)C=C3)=NC=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as sulfinylbenzimidazoles. These are polycyclic aromatic compounds containing a sulfinyl group attached at the position 2 of a benzimidazole moiety.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzimidazoles
Sub ClassSulfinylbenzimidazoles
Direct ParentSulfinylbenzimidazoles
Alternative Parents
Substituents
  • Sulfinylbenzimidazole
  • Alkyl aryl ether
  • Benzenoid
  • Pyridine
  • Heteroaromatic compound
  • Imidazole
  • Azole
  • Sulfoxide
  • Azacycle
  • Sulfinyl compound
  • Ether
  • Halomethane
  • Hydrocarbon derivative
  • Organosulfur compound
  • Organooxygen compound
  • Organonitrogen compound
  • Organofluoride
  • Organohalogen compound
  • Alkyl halide
  • Alkyl fluoride
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationShort-term (up to 16 weeks) treatment of erosive esophagitis.
PharmacodynamicsPantoprazole is a substituted benzimidazole indicated for the short-term treatment (up to 16 weeks) in the healing and symptomatic relief of erosive esophagitis. Pantoprazole is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production.
Mechanism of actionPantoprazole is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production by forming a covalent bond to two sites of the (H+,K+ )- ATPase enzyme system at the secretory surface of the gastric parietal cell. This effect is dose- related and leads to inhibition of both basal and stimulated gastric acid secretion irrespective of the stimulus.
AbsorptionPantoprazole is well absorbed. It undergoes little first-pass metabolism resulting in an absolute bioavailability of approximately 77%.
Volume of distribution
  • 11.0 to 23.6 L
Protein binding98%
Metabolism

Pantoprazole is extensively metabolized in the liver through the cytochrome P450 (CYP) system. The main metabolic pathway is demethylation, by CYP2C19, with subsequent sulfation; other metabolic pathways include oxidation by CYP3A4. There is no evidence that any of the pantoprazole metabolites have significant pharmacologic activity.

SubstrateEnzymesProduct
Pantoprazole
Not Available
Active Metabolite of PantoprazoleDetails
Route of eliminationAfter administration of a single intravenous dose of 14C-labeled pantoprazole to healthy, normal metabolizer subjects, approximately 71% of the dose was excreted in the urine with 18% excreted in the feces through biliary excretion.
Half life1 hour
Clearance
  • 7.6-14.0 L/h
ToxicitySingle intravenous doses of pantoprazole at 378, 230, and 266 mg/kg (38, 46, and 177 times the recommended human dose based on body surface area) were lethal to mice, rats and dogs, respectively. The symptoms of toxicity included hypoactivity, ataxia, hunched sitting, limb-splay, lateral position, segregation, absence of ear reflex, and tremor. There is limited experience regarding cases of human overdosage, and treatment should be symptomatic and supportive.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Pantoprazole Metabolism PathwayDrug metabolismSMP00615
Pantoprazole Action PathwayDrug actionSMP00228
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9935
Blood Brain Barrier-0.5777
Caco-2 permeable+0.7262
P-glycoprotein substrateNon-substrate0.6127
P-glycoprotein inhibitor IInhibitor0.5587
P-glycoprotein inhibitor IINon-inhibitor0.9198
Renal organic cation transporterNon-inhibitor0.6285
CYP450 2C9 substrateNon-substrate0.84
CYP450 2D6 substrateNon-substrate0.8683
CYP450 3A4 substrateSubstrate0.7254
CYP450 1A2 substrateInhibitor0.7639
CYP450 2C9 substrateNon-inhibitor0.8054
CYP450 2D6 substrateNon-inhibitor0.7308
CYP450 2C19 substrateInhibitor0.7877
CYP450 3A4 substrateNon-inhibitor0.7258
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.903
Ames testNon AMES toxic0.5527
CarcinogenicityNon-carcinogens0.8108
BiodegradationNot ready biodegradable0.9972
Rat acute toxicity2.3466 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9228
hERG inhibition (predictor II)Non-inhibitor0.8734
Pharmacoeconomics
Manufacturers
  • Wyeth pharmaceuticals inc
  • Kudco ireland ltd
  • Sun pharma global inc
  • Teva pharmaceuticals usa inc
Packagers
Dosage forms
FormRouteStrength
Injection, powder, for solutionintravenous40 mg
Injection, powder, for solutionintravenous40 mg/10mL
Tabletoral40 mg
Tablet (delayed-release)oral20 mg
Tablet (delayed-release)oral40 mg
Tablet (enteric-coated)oral20 mg
Tablet (enteric-coated)oral40 mg
Tablet, delayed releaseoral20 mg
Tablet, delayed releaseoral40 mg
Prices
Unit descriptionCostUnit
Protonix iv 40 mg vial14.4USD vial
Protonix 40 mg tablet dr8.91USD tablet
Protonix 20 mg tablet5.43USD tab
Protonix 40 mg Enteric Coated Tabs5.43USD tab
Protonix dr 20 mg tablet5.22USD tablet
Protonix dr 40 mg tablet5.22USD tablet
Pantoprazole Sodium 20 mg Enteric Coated Tabs4.26USD tab
Pantoprazole Sodium 40 mg Enteric Coated Tabs4.26USD tab
Pantoprazole sod dr 20 mg tablet3.93USD tablet
Pantoprazole sod dr 40 mg tablet3.93USD tablet
Pantoloc 40 mg Enteric-Coated Tablet2.28USD tablet
Apo-Pantoprazole 40 mg Enteric-Coated Tablet1.27USD tablet
Co Pantoprazole 40 mg Enteric-Coated Tablet1.27USD tablet
Mylan-Pantoprazole 40 mg Enteric-Coated Tablet1.27USD tablet
Novo-Pantoprazole 40 mg Enteric-Coated Tablet1.27USD tablet
Phl-Pantoprazole 40 mg Enteric-Coated Tablet1.27USD tablet
Pms-Pantoprazole 40 mg Enteric-Coated Tablet1.27USD tablet
Ran-Pantoprazole 40 mg Enteric-Coated Tablet1.27USD tablet
Ratio-Pantoprazole 40 mg Enteric-Coated Tablet1.27USD tablet
Sandoz Pantoprazole 40 mg Enteric-Coated Tablet1.27USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
CountryPatent NumberApprovedExpires (estimated)
Canada20926942005-04-052011-09-06
Canada23410312006-04-042019-08-12
Canada24288702006-05-232021-11-17
United States47585791993-07-192010-07-19
United States75443702006-12-072026-12-07
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting pointBecause of gradual degradation of pantoprazole sodium during heating, the melting point cannot be determined.Not Available
water solubilityFreely soluble in water.Not Available
logP0.5Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.495 mg/mLALOGPS
logP2.11ALOGPS
logP2.18ChemAxon
logS-2.9ALOGPS
pKa (Strongest Acidic)9.15ChemAxon
pKa (Strongest Basic)3.55ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area86.33 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity90.05 m3·mol-1ChemAxon
Polarizability35.17 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

Rudolf Linder, “Freeze-dried pantoprazole preparation and pantoprazole injection.” U.S. Patent US20030003058, issued January 02, 2003.

US20030003058
General ReferenceNot Available
External Links
ATC CodesA02BC02
AHFS Codes
  • 56:28.36
PDB EntriesNot Available
FDA labelDownload (183 KB)
MSDSDownload (58.1 KB)
Interactions
Drug Interactions
Drug
AmphetamineMay increase the absorption of Amphetamine.
AtazanavirProton Pump Inhibitors may decrease the serum concentration of Atazanavir.
BosutinibProton Pump Inhibitors may decrease the serum concentration of Bosutinib.
CefditorenProton Pump Inhibitors may decrease the serum concentration of Cefditoren.
ClodronateMay diminish the therapeutic effect of Bisphosphonate Derivatives.
ClopidogrelPantoprazole may decrease serum concentrations of the active metabolite(s) of Clopidogrel.
Dabigatran etexilateProton Pump Inhibitors may decrease serum concentrations of the active metabolite(s) of Dabigatran Etexilate.
DabrafenibMay decrease the serum concentration of CYP2C19 Substrates.
DasatinibProton Pump Inhibitors may decrease the serum concentration of Dasatinib.
DelavirdineProton Pump Inhibitors may decrease the serum concentration of Delavirdine.
DexmethylphenidateProton Pump Inhibitors may increase the absorption of Dexmethylphenidate. Specifically, proton pump inhibitors may interfere with the normal release of drug from the extended-release capsules (Focalin XR brand), which could result in both increased absorption (early) and decreased delayed absorption.
DextroamphetamineProton Pump Inhibitors may increase the absorption of Dextroamphetamine. Specifically, the dextroamphetamine absorption rate from mixed amphetamine salt extended release (XR) capsules may be increased in the first hours after dosing.
ErlotinibProton Pump Inhibitors may decrease the serum concentration of Erlotinib.
FluconazoleFluconazole may increase the serum concentration of Proton Pump Inhibitors.
GefitinibProton Pump Inhibitors may decrease the serum concentration of Gefitinib.
IbandronateMay diminish the therapeutic effect of Bisphosphonate Derivatives.
IndinavirProton Pump Inhibitors may decrease the serum concentration of Indinavir.
ItraconazoleProton Pump Inhibitors may decrease the serum concentration of Itraconazole.
LedipasvirProton Pump Inhibitors may decrease the serum concentration of Ledipasvir.
MesalazineMay diminish the therapeutic effect of Mesalamine. Proton pump inhibitor-mediated increases in gastrointestinal pH may cause the premature release of mesalamine from specific sustained-release mesalamine products.
MethotrexateProton Pump Inhibitors may increase the serum concentration of Methotrexate.
MethylphenidateProton Pump Inhibitors may increase the absorption of Methylphenidate. Specifically, proton pump inhibitors may interfere with the normal release of drug from the extended-release capsules (Ritalin LA brand), which could result in both increased absorption (early) and decreased delayed absorption.
Mycophenolate mofetilMay decrease the serum concentration of Mycophenolate. Specifically, concentrations of the active mycophenolic acid may be reduced.
Mycophenolic acidMay decrease the serum concentration of Mycophenolate. Specifically, concentrations of the active mycophenolic acid may be reduced.
NelfinavirProton Pump Inhibitors may decrease serum concentrations of the active metabolite(s) of Nelfinavir. Proton Pump Inhibitors may decrease the serum concentration of Nelfinavir.
NilotinibProton Pump Inhibitors may decrease the serum concentration of Nilotinib.
PamidronateMay diminish the therapeutic effect of Bisphosphonate Derivatives.
PazopanibBCRP/ABCG2 Inhibitors may increase the serum concentration of PAZOPanib.
PosaconazoleProton Pump Inhibitors may decrease the serum concentration of Posaconazole.
RaltegravirProton Pump Inhibitors may increase the serum concentration of Raltegravir.
RilpivirineProton Pump Inhibitors may decrease the serum concentration of Rilpivirine.
RiociguatProton Pump Inhibitors may decrease the serum concentration of Riociguat.
RisedronateProton Pump Inhibitors may diminish the therapeutic effect of Risedronate. Proton Pump Inhibitors may increase the serum concentration of Risedronate. This applies specifically to use of delayed-release risedronate.
SaquinavirProton Pump Inhibitors may increase the serum concentration of Saquinavir.
TiludronateMay diminish the therapeutic effect of Bisphosphonate Derivatives.
TipranavirMay decrease the serum concentration of Proton Pump Inhibitors. These data are derived from studies with Ritonavir-boosted Tipranavir.
TopotecanBCRP/ABCG2 Inhibitors may increase the serum concentration of Topotecan.
VismodegibProton Pump Inhibitors may decrease the serum concentration of Vismodegib.
VoriconazoleProton Pump Inhibitors may increase the serum concentration of Voriconazole. Voriconazole may increase the serum concentration of Proton Pump Inhibitors.
ZoledronateMay diminish the therapeutic effect of Bisphosphonate Derivatives.
Food Interactions
  • Take without regard to meals.

Targets

1. Potassium-transporting ATPase alpha chain 1

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
Potassium-transporting ATPase alpha chain 1 P20648 Details

References:

  1. Moreira Dias L: Pantoprazole: a proton pump inhibitor. Clin Drug Investig. 2009;29 Suppl 2:3-12. Pubmed
  2. Cheer SM, Prakash A, Faulds D, Lamb HM: Pantoprazole: an update of its pharmacological properties and therapeutic use in the management of acid-related disorders. Drugs. 2003;63(1):101-33. Pubmed
  3. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed

Enzymes

1. Cytochrome P450 2C19

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2C19 P33261 Details

References:

  1. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed
  3. Lexicomp

2. Cytochrome P450 3A4

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inducer

Components

Name UniProt ID Details
Cytochrome P450 3A4 P08684 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

3. Cytochrome P450 2C9

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2C9 P11712 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

4. Cytochrome P450 1A2

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inducer

Components

Name UniProt ID Details
Cytochrome P450 1A2 P05177 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

Transporters

1. Multidrug resistance protein 1

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Multidrug resistance protein 1 P08183 Details

References:

  1. Pauli-Magnus C, Rekersbrink S, Klotz U, Fromm MF: Interaction of omeprazole, lansoprazole and pantoprazole with P-glycoprotein. Naunyn Schmiedebergs Arch Pharmacol. 2001 Dec;364(6):551-7. Pubmed

2. ATP-binding cassette sub-family G member 2

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
ATP-binding cassette sub-family G member 2 Q9UNQ0 Details

References:

  1. Breedveld P, Zelcer N, Pluim D, Sonmezer O, Tibben MM, Beijnen JH, Schinkel AH, van Tellingen O, Borst P, Schellens JH: Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions. Cancer Res. 2004 Aug 15;64(16):5804-11. Pubmed
  2. Suzuki K, Doki K, Homma M, Tamaki H, Hori S, Ohtani H, Sawada Y, Kohda Y: Co-administration of proton pump inhibitors delays elimination of plasma methotrexate in high-dose methotrexate therapy. Br J Clin Pharmacol. 2009 Jan;67(1):44-9. Epub 2008 Nov 17. Pubmed
  3. Dahan A, Amidon GL: Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting. Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G371-7. Epub 2009 Jun 18. Pubmed

3. Solute carrier organic anion transporter family member 1B1

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Solute carrier organic anion transporter family member 1B1 Q9Y6L6 Details

References:

  1. Oostendorp RL, van de Steeg E, van der Kruijssen CM, Beijnen JH, Kenworthy KE, Schinkel AH, Schellens JH: Organic anion-transporting polypeptide 1B1 mediates transport of Gimatecan and BNP1350 and can be inhibited by several classic ATP-binding cassette (ABC) B1 and/or ABCG2 inhibitors. Drug Metab Dispos. 2009 Apr;37(4):917-23. Epub 2009 Jan 12. Pubmed

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Drug created on June 13, 2005 07:24 / Updated on September 16, 2013 17:08