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Identification
NameLovastatin
Accession NumberDB00227  (APRD00370)
TypeSmall Molecule
GroupsApproved, Investigational
DescriptionLovastatin is a cholesterol-lowering agent that belongs to the class of medications called statins. It was the second agent of this class discovered. It was discovered by Alfred Alberts and his team at Merck in 1978 after screening only 18 compounds over 2 weeks. The agent, also known as mevinolin, was isolated from the fungi Aspergillus terreus. Research on this compound was suddenly shut down in 1980 and the drug was not approved until 1987. Interesting, Akira Endo at Sankyo Co. (Japan) patented lovastatin isolated from Monascus ruber four months before Merck. Lovastatin was found to be 2 times more potent than its predecessor, mevastatin, the first discovered statin. Like mevastatin, lovastatin is structurally similar to hydroxymethylglutarate (HMG), a substituent of HMG-Coenzyme A (HMG-CoA), a substrate of the cholesterol biosynthesis pathway via the mevalonic acid pathway. Lovastatin is a competitive inhibitor of HMG-CoA reductase with a binding affinity 20,000 times greater than HMG-CoA. Lovastatin differs structurally from mevastatin by a single methyl group at the 6’ position. Lovastatin is a prodrug that is activated by in vivo hydrolysis of the lactone ring. It, along with mevastatin, has served as one of the lead compounds for the development of the synthetic compounds used today.
Structure
Thumb
Synonyms
(1S,3R,7S,8S,8AR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate
2beta,6alpha-Dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactone
6-alpha-methylcompactin
6alpha-Methylcompactin
6α-methylcompactin
LOVASTATIN
Lovastatina
Lovastatine
Lovastatinum
Mevacor
Mevinolin
MK-803
ML-530b
External Identifiers
  • MK-803
  • ML-530B
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Act Lovastatintablet20 mgoralActavis Pharma Company2004-07-28Not applicableCanada
Act Lovastatintablet40 mgoralActavis Pharma Company2004-07-28Not applicableCanada
Altoprevtablet, extended release40 mg/1oralShionogi Inc.2002-06-262018-02-28Us
Altoprevtablet, extended release60 mg/1oralShionogi Inc.2002-06-262016-12-31Us
Altoprevtablet, extended release20 mg/1oralShionogi Inc.2002-06-262017-12-31Us
Ava-lovastatintablet20 mgoralAvanstra Inc2011-08-182014-08-21Canada
Ava-lovastatintablet40 mgoralAvanstra Inc2011-08-182014-08-21Canada
Dom-lovastatintablet20 mgoralDominion Pharmacal2003-02-25Not applicableCanada
Dom-lovastatintablet40 mgoralDominion Pharmacal2003-02-25Not applicableCanada
Lovastatintablet40 mgoralSanis Health Inc2010-07-26Not applicableCanada
Lovastatintablet40 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Lovastatintablet20 mgoralSanis Health Inc2010-07-26Not applicableCanada
Lovastatintablet20 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Lovastatin-20tablet20 mgoralPro Doc Limitee2003-08-152008-07-09Canada
Lovastatin-40tablet40 mgoralPro Doc Limitee2003-08-152008-07-09Canada
Mevacortablet20 mg/1oralMerck Sharp & Dohme Corp.1987-08-31Not applicableUs
Mevacortablet40 mg/1oralMerck Sharp & Dohme Corp.1987-08-31Not applicableUs
Mevacortablet20 mgoralMerck Canada Inc1988-12-312014-06-06Canada
Mevacortablet40 mgoralMerck Canada Inc1990-12-312014-06-06Canada
Mylan-lovastatintablet20 mgoralMylan Pharmaceuticals Ulc2001-02-08Not applicableCanada
Mylan-lovastatintablet40 mgoralMylan Pharmaceuticals Ulc2001-02-19Not applicableCanada
Nu-lovastatin Tabletstablet20 mgoralNu Pharm Inc2004-12-172012-09-04Canada
PHL-lovastatintablet20 mgoralPharmel Inc2003-01-07Not applicableCanada
PHL-lovastatintablet40 mgoralPharmel Inc2003-01-07Not applicableCanada
PMS-lovastatintablet20 mgoralPharmascience Inc2002-07-12Not applicableCanada
PMS-lovastatintablet40 mgoralPharmascience Inc2002-07-16Not applicableCanada
Pro-lovastatintablet20 mgoralPro Doc Limitee2008-07-09Not applicableCanada
Pro-lovastatintablet40 mgoralPro Doc Limitee2008-07-09Not applicableCanada
Ran-lovastatintablet20 mgoralRanbaxy Pharmaceuticals Canada Inc.2005-07-052012-06-13Canada
Ran-lovastatintablet40 mgoralRanbaxy Pharmaceuticals Canada Inc.2005-07-052012-06-13Canada
Ratio-lovastatintablet20 mgoralRatiopharm Inc Division Of Teva Canada Limited2002-05-222013-01-09Canada
Ratio-lovastatintablet40 mgoralRatiopharm Inc Division Of Teva Canada Limited2002-05-222013-01-09Canada
Riva-lovastatintablet40 mgoralLaboratoire Riva Inc2005-12-07Not applicableCanada
Riva-lovastatintablet20 mgoralLaboratoire Riva Inc2005-12-01Not applicableCanada
Sandoz Lovastatintablet40 mgoralSandoz Canada Incorporated2003-02-27Not applicableCanada
Sandoz Lovastatintablet20 mgoralSandoz Canada Incorporated2003-02-27Not applicableCanada
Teva-lovastatintablet20 mgoralTeva Canada Limited2003-01-20Not applicableCanada
Teva-lovastatintablet40 mgoralTeva Canada Limited2003-01-20Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-lovastatin - Tab 20mgtablet20 mgoralApotex Inc1997-03-27Not applicableCanada
Apo-lovastatin - Tab 40mgtablet40 mgoralApotex Inc1997-03-27Not applicableCanada
Lovastatintablet10 mg/1oralPd Rx Pharmaceuticals, Inc.2007-11-01Not applicableUs
Lovastatintablet10 mg/1oralREMEDYREPACK INC.2013-02-13Not applicableUs
Lovastatintablet40 mg/1oralREMEDYREPACK INC.2014-02-20Not applicableUs
Lovastatintablet20 mg/1oralCardinal Health2011-08-18Not applicableUs
Lovastatintablet40 mg/1oralCarlsbad Technology, Inc.2002-11-25Not applicableUs
Lovastatintablet10 mg/1oralAphena Pharma Solutions Tennessee, Llc2001-12-17Not applicableUs
Lovastatintablet40 mg/1oralPreferred Pharmaceuticals, Inc2005-10-27Not applicableUs
Lovastatintablet20 mg/1oralEon Labs, Inc.2001-12-17Not applicableUs
Lovastatintablet20 mg/1oralBlenheim Pharmacal, Inc.2010-06-22Not applicableUs
Lovastatintablet40 mg/1oralAidarex Pharmaceuticals LLC2002-11-25Not applicableUs
Lovastatintablet40 mg/1oralREMEDYREPACK INC.2011-09-23Not applicableUs
Lovastatintablet10 mg/1oralUnit Dose Services2002-11-25Not applicableUs
Lovastatintablet10 mg/1oralInternational Labs, Inc.2008-03-27Not applicableUs
Lovastatintablet20 mg/1oralGolden State Medical Supply, Inc.2014-06-24Not applicableUs
Lovastatintablet40 mg/1oralbryant ranch prepack2001-12-17Not applicableUs
Lovastatintablet20 mg/1oralLupin Pharmaceuticals, Inc.2007-11-01Not applicableUs
Lovastatintablet20 mg/1oralTeva Pharmaceuticals USA Inc2001-12-17Not applicableUs
Lovastatintablet10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-11-01Not applicableUs
Lovastatintablet40 mg/1oralMylan Pharmaceuticals Inc.2001-12-17Not applicableUs
Lovastatintablet40 mg/1oralRebel Distributors Corp2007-11-01Not applicableUs
Lovastatintablet20 mg/1oralActavis Inc.2001-12-17Not applicableUs
Lovastatintablet40 mg/1oralLake Erie Medical DBA Quality Care Products LLC2007-11-01Not applicableUs
Lovastatintablet40 mg/1oralInternational Labs, Inc.2015-05-20Not applicableUs
Lovastatintablet10 mg/1oralGolden State Medical Supply, Inc.2002-11-25Not applicableUs
Lovastatintablet20 mg/1oralProficient Rx LP2002-11-25Not applicableUs
Lovastatintablet10 mg/1oralAmerican Health Packaging2012-01-31Not applicableUs
Lovastatintablet20 mg/1oralPreferred Pharmaceuticals, Inc.2013-03-18Not applicableUs
Lovastatintablet20 mg/1oralKAISER FOUNDATION HOSPITALS2011-07-18Not applicableUs
Lovastatintablet10 mg/1oralBlenheim Pharmacal, Inc.2013-10-09Not applicableUs
Lovastatintablet10 mg/1oralRebel Distributors Corp2002-11-25Not applicableUs
Lovastatintablet10 mg/1oralREMEDYREPACK INC.2011-10-20Not applicableUs
Lovastatintablet10 mg/1oralNorthwind Pharmaceuticals, LLC2014-11-04Not applicableUs
Lovastatintablet20 mg/1oralPhysicians Total Care, Inc.2001-12-21Not applicableUs
Lovastatintablet40 mg/1oralSt Marys Medical Park Pharmacy2014-04-21Not applicableUs
Lovastatintablet10 mg/1oralDispensing Solutions, Inc.2002-11-25Not applicableUs
Lovastatintablet40 mg/1oralPd Rx Pharmaceuticals, Inc.2002-11-25Not applicableUs
Lovastatintablet20 mg/1oralREMEDYREPACK INC.2013-02-15Not applicableUs
Lovastatintablet10 mg/1oralMutual Pharmaceutical Company, Inc.2006-04-14Not applicableUs
Lovastatintablet20 mg/1oralCardinal Health2010-12-14Not applicableUs
Lovastatintablet10 mg/1oralDIRECT RX2014-01-01Not applicableUs
Lovastatintablet10 mg/1oralBlue Point Laboratories2014-02-10Not applicableUs
Lovastatintablet20 mg/1oralPreferred Pharmaceuticals, Inc.2013-07-29Not applicableUs
Lovastatintablet40 mg/1oralEon Labs, Inc.2001-12-17Not applicableUs
Lovastatintablet10 mg/1oralSTAT Rx USA LLC2007-11-01Not applicableUs
Lovastatintablet20 mg/1oralLake Erie Medical DBA Quality Care Products LLC2001-12-17Not applicableUs
Lovastatintablet10 mg/1oralREMEDYREPACK INC.2011-10-24Not applicableUs
Lovastatintablet40 mg/1oralUnit Dose Services2002-11-25Not applicableUs
Lovastatintablet40 mg/1oralInternational Labs, Inc.2010-04-10Not applicableUs
Lovastatintablet40 mg/1oralGolden State Medical Supply, Inc.2014-06-24Not applicableUs
Lovastatintablet10 mg/1oralbryant ranch prepack2002-11-25Not applicableUs
Lovastatintablet40 mg/1oralLupin Pharmaceuticals, Inc.2007-11-01Not applicableUs
Lovastatintablet10 mg/1oralTeva Pharmaceuticals USA Inc2001-12-17Not applicableUs
Lovastatintablet20 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2001-12-17Not applicableUs
Lovastatintablet20 mg/1oralAmerican Health Packaging2012-01-31Not applicableUs
Lovastatintablet20 mg/1oralDIRECT RX2016-03-03Not applicableUs
Lovastatintablet20 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2001-12-17Not applicableUs
Lovastatintablet20 mg/1oralREMEDYREPACK INC.2011-12-12Not applicableUs
Lovastatintablet40 mg/1oralActavis Inc.2001-12-17Not applicableUs
Lovastatintablet10 mg/1oralAv Pak2014-04-29Not applicableUs
Lovastatintablet20 mg/1oralInternational Labs, Inc.2015-05-20Not applicableUs
Lovastatintablet20 mg/1oralGolden State Medical Supply, Inc.2002-11-25Not applicableUs
Lovastatintablet10 mg/1oralProficient Rx LP2002-11-25Not applicableUs
Lovastatintablet10 mg/1oralCarlsbad Technology, Inc.2002-11-25Not applicableUs
Lovastatintablet20 mg/1oralAphena Pharma Solutions Tennessee, Llc2001-12-17Not applicableUs
Lovastatintablet10 mg/1oralPreferred Pharmaceuticals, Inc2005-10-27Not applicableUs
Lovastatintablet40 mg/1oralKAISER FOUNDATION HOSPITALS2011-07-18Not applicableUs
Lovastatintablet20 mg/1oralBlenheim Pharmacal, Inc.2013-10-09Not applicableUs
Lovastatintablet20 mg/1oralAv Kare, Inc.2002-06-06Not applicableUs
Lovastatintablet40 mg/1oralREMEDYREPACK INC.2011-12-02Not applicableUs
Lovastatintablet20 mg/1oralREMEDYREPACK INC.2013-05-14Not applicableUs
Lovastatintablet10 mg/1oralPhysicians Total Care, Inc.2002-01-28Not applicableUs
Lovastatintablet40 mg/1oralAphena Pharma Solutions Tennessee, Llc2002-06-06Not applicableUs
Lovastatintablet40 mg/1oralREMEDYREPACK INC.2012-09-11Not applicableUs
Lovastatintablet20 mg/1oralMutual Pharmaceutical Company, Inc.2006-04-14Not applicableUs
Lovastatintablet40 mg/1oralPd Rx Pharmaceuticals, Inc.2007-11-01Not applicableUs
Lovastatintablet20 mg/1oralDIRECT RX2014-01-01Not applicableUs
Lovastatintablet40 mg/1oralBlue Point Laboratories2014-02-10Not applicableUs
Lovastatintablet40 mg/1oralPreferred Pharmaceuticals, Inc.2013-07-29Not applicableUs
Lovastatintablet10 mg/1oralMylan Pharmaceuticals Inc.2001-12-17Not applicableUs
Lovastatintablet10 mg/1oralRebel Distributors Corp2007-11-01Not applicableUs
Lovastatintablet40 mg/1oralRebel Distributors Corp2002-11-25Not applicableUs
Lovastatintablet40 mg/1oralREMEDYREPACK INC.2011-03-09Not applicableUs
Lovastatintablet20 mg/1oralUnit Dose Services2002-11-25Not applicableUs
Lovastatintablet20 mg/1oralInternational Labs, Inc.2010-04-03Not applicableUs
Lovastatintablet20 mg/1oralSt Marys Medical Park Pharmacy2013-07-11Not applicableUs
Lovastatintablet20 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2007-09-12Not applicableUs
Lovastatintablet40 mg/1oralPreferred Pharmaceuticals, Inc.2013-03-18Not applicableUs
Lovastatintablet40 mg/1oralTeva Pharmaceuticals USA Inc2001-12-17Not applicableUs
Lovastatintablet40 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2001-12-17Not applicableUs
Lovastatintablet40 mg/1oralGolden State Medical Supply, Inc.2002-11-25Not applicableUs
Lovastatintablet40 mg/1oralProficient Rx LP2002-11-25Not applicableUs
Lovastatintablet40 mg/1oralAmerican Health Packaging2012-01-31Not applicableUs
Lovastatintablet40 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2001-12-17Not applicableUs
Lovastatintablet10 mg/1oralAidarex Pharmaceuticals LLC2002-11-25Not applicableUs
Lovastatintablet10 mg/1oralREMEDYREPACK INC.2010-10-17Not applicableUs
Lovastatintablet20 mg/1oralAv Pak2014-04-29Not applicableUs
Lovastatintablet40 mg/1oralInternational Labs, Inc.2008-03-27Not applicableUs
Lovastatintablet10 mg/1oralREMEDYREPACK INC.2013-09-26Not applicableUs
Lovastatintablet40 mg/1oralPhysicians Total Care, Inc.2003-04-14Not applicableUs
Lovastatintablet20 mg/1oralCarlsbad Technology, Inc.2002-11-25Not applicableUs
Lovastatintablet40 mg/1oralAphena Pharma Solutions Tennessee, Llc2001-12-17Not applicableUs
Lovastatintablet20 mg/1oralPreferred Pharmaceuticals, Inc2005-10-27Not applicableUs
Lovastatintablet10 mg/1oralEon Labs, Inc.2001-12-17Not applicableUs
Lovastatintablet40 mg/1oralBlenheim Pharmacal, Inc.2013-10-09Not applicableUs
Lovastatintablet40 mg/1oralAv Kare, Inc.2002-06-06Not applicableUs
Lovastatintablet20 mg/1oralREMEDYREPACK INC.2013-04-09Not applicableUs
Lovastatintablet20 mg/1oralRebel Distributors Corp2007-11-01Not applicableUs
Lovastatintablet10 mg/1oralActavis Inc.2001-12-17Not applicableUs
Lovastatintablet10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2001-12-17Not applicableUs
Lovastatintablet40 mg/1oralMutual Pharmaceutical Company, Inc.2006-04-14Not applicableUs
Lovastatintablet20 mg/1oralPd Rx Pharmaceuticals, Inc.2007-11-01Not applicableUs
Lovastatintablet40 mg/1oralDIRECT RX2014-01-01Not applicableUs
Lovastatintablet20 mg/1oralBlue Point Laboratories2014-02-10Not applicableUs
Lovastatintablet20 mg/1oralMylan Pharmaceuticals Inc.2001-12-17Not applicableUs
Lovastatintablet10 mg/1oralKAISER FOUNDATION HOSPITALS2011-07-18Not applicableUs
Lovastatintablet40 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2001-12-17Not applicableUs
Lovastatintablet20 mg/1oralRebel Distributors Corp2002-11-25Not applicableUs
Lovastatintablet10 mg/1oralREMEDYREPACK INC.2011-03-16Not applicableUs
Lovastatintablet20 mg/1oralMylan Institutional Inc.2002-01-15Not applicableUs
Lovastatintablet10 mg/1oralInternational Labs, Inc.2010-03-22Not applicableUs
Lovastatintablet10 mg/1oralSt Marys Medical Park Pharmacy2014-01-30Not applicableUs
Lovastatintablet40 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2007-08-06Not applicableUs
Lovastatintablet10 mg/1oralPreferred Pharmaceuticals, Inc.2013-03-18Not applicableUs
Lovastatintablet40 mg/1oralAv Pak2014-04-29Not applicableUs
Lovastatintablet20 mg/1oralInternational Labs, Inc.2008-03-27Not applicableUs
Lovastatintablet10 mg/1oralGolden State Medical Supply, Inc.2014-06-24Not applicableUs
Lovastatintablet20 mg/1oralbryant ranch prepack2009-06-15Not applicableUs
Lovastatintablet10 mg/1oralLupin Pharmaceuticals, Inc.2007-11-01Not applicableUs
Lovastatintablet10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2001-12-17Not applicableUs
Lovastatintablet20 mg/1oralAidarex Pharmaceuticals LLC2002-11-25Not applicableUs
Lovastatintablet40 mg/1oralREMEDYREPACK INC.2011-06-17Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AltocorNot Available
Brand mixtures
NameLabellerIngredients
AdvicorAbb Vie Inc.
SaltsNot Available
Categories
UNII9LHU78OQFD
CAS number75330-75-5
WeightAverage: 404.5396
Monoisotopic: 404.256274262
Chemical FormulaC24H36O5
InChI KeyInChIKey=PCZOHLXUXFIOCF-BXMDZJJMSA-N
InChI
InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1
IUPAC Name
(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
SMILES
[H][C@]12[[email protected]](C[C@@H](C)C=C1C=C[[email protected]](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1)OC(=O)[C@@H](C)CC
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as delta valerolactones. These are cyclic organic compounds containing an oxan-2- one moiety.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassLactones
Sub ClassDelta valerolactones
Direct ParentDelta valerolactones
Alternative Parents
Substituents
  • Delta_valerolactone
  • Fatty acid ester
  • Delta valerolactone
  • Fatty acyl
  • Oxane
  • Dicarboxylic acid or derivatives
  • Saccharide
  • Secondary alcohol
  • Carboxylic acid ester
  • Oxacycle
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Alcohol
  • Aliphatic heteropolycyclic compound
Molecular FrameworkAliphatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor management as an adjunct to diet to reduce elevated total-C, LDL-C, apo B, and TG levels in patients with primary hypercholesterolemia and mixed dyslipidemia. For primary prevention of coronary heart disease and to slow progression of coronary atherosclerosis in patients with coronary heart disease.
PharmacodynamicsThe primary cause of cardiovascular disease is atherosclerotic plaque formation. Sustained elevations of cholesterol in the blood increase the risk of cardiovascular disease. Lovastatin lowers hepatic cholesterol synthesis by competitively inhibiting HMG-CoA reductase, the enzyme that catalyzes the rate-limiting step in the cholesterol biosynthesis pathway via the mevalonic acid pathway. Decreased hepatic cholesterol levels causes increased uptake of low density lipoprotein (LDL) cholesterol and reduces cholesterol levels in the circulation. At therapeutic doses, lovastatin decreases serum LDL cholesterol by 29-32%, increases high density lipoprotein (HDL) cholesterol by 4.6-7.3%, and decrease triglyceride levels by 2-12%. HDL cholesterol is thought to confer protective effects against CV disease, whereas high LDL and triglyceride levels are associated with higher risk of disease.
Mechanism of actionLovastatin is structurally similar to the HMG, a substituent of the endogenous substrate of HMG-CoA reductase. Lovastatin is a prodrug that is activated in vivo via hydrolysis of the lactone ring to form the β-hydroxyacid. The hydrolyzed lactone ring mimics the tetrahedral intermediate produced by the reductase allowing the agent to bind to HMG-CoA reductase with 20,000 times greater affinity than its natural substrate. The bicyclic portion of lovastatin binds to the coenzyme A portion of the active site.
Related Articles
AbsorptionStudies suggest that <5% of the oral dose reaches the general circulation as active inhibitors. Time to peak serum concentration is 2-4 hours. Lovastatin undergoes extensive first-pass metabolism so the availability of the drug in the system is low and variable.
Volume of distribution

Lovastatin is able to cross the blood-brain-barrier and placenta.

Protein bindingLovastatin and its β-hydroxyacid metabolites are highly protein bound (>95%).
Metabolism

Lovastatin is hepatically metabolized in which the major active metabolites are the β-hydroxyacid of lovastatin, the 6’-hydroxy derivative, and two additional metabolites.

Route of eliminationLovastatin undergoes extensive first-pass extraction in the liver, its primary site of action, with subsequent excretion of drug equivalents in the bile. 83% of the orally administered dose is excreted in bile and 10% is excreted in urine.
Half life5.3 hours
ClearanceNot Available
ToxicityLD50>1000 mg/kg (orally in mice)
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Lovastatin Action PathwayDrug actionSMP00099
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9452
Blood Brain Barrier+0.9287
Caco-2 permeable-0.5484
P-glycoprotein substrateSubstrate0.7861
P-glycoprotein inhibitor IInhibitor0.7046
P-glycoprotein inhibitor IIInhibitor0.8388
Renal organic cation transporterNon-inhibitor0.8299
CYP450 2C9 substrateNon-substrate0.8333
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.6868
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.9291
CYP450 2D6 inhibitorNon-inhibitor0.923
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorInhibitor0.796
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8682
Ames testNon AMES toxic0.8475
CarcinogenicityNon-carcinogens0.9519
BiodegradationNot ready biodegradable0.8819
Rat acute toxicity2.0554 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.7272
hERG inhibition (predictor II)Non-inhibitor0.7484
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Andrx labs llc
  • Actavis elizabeth llc
  • Apotex inc
  • Carlsbad technology inc
  • Lupin ltd
  • Mutual pharmaceutical co inc
  • Mylan pharmaceuticals inc
  • Sandoz inc
  • Teva pharmaceuticals usa inc
  • Merck research laboratories div merck co inc
Packagers
Dosage forms
FormRouteStrength
Tablet (immediate release); tablet (extended-release)oral
Tablet, extended releaseoral
Tablet, extended releaseoral20 mg/1
Tablet, extended releaseoral40 mg/1
Tablet, extended releaseoral60 mg/1
Tabletoral20 mg
Tabletoral40 mg
Tabletoral10 mg/1
Tabletoral20 mg/1
Tabletoral40 mg/1
Prices
Unit descriptionCostUnit
Altoprev 60 mg 24 Hour tablet7.99USD tablet
Altoprev 60 mg tablet7.74USD tablet
Altoprev 20 mg 24 Hour tablet6.88USD tablet
Altoprev 20 mg tablet6.61USD tablet
Mevacor 40 mg tablet4.57USD tablet
Altoprev 40 mg tablet4.41USD tablet
Lovastatin 40 mg tablet4.36USD tablet
Altoprev 10 mg 24 Hour tablet3.07USD tablet
Mevacor 20 mg tablet2.53USD tablet
Lovastatin 20 mg tablet2.42USD tablet
Altocor 20 mg 24 Hour tablet2.36USD tablet
Apo-Lovastatin 40 mg Tablet2.11USD tablet
Co Lovastatin 40 mg Tablet2.11USD tablet
Mylan-Lovastatin 40 mg Tablet2.11USD tablet
Novo-Lovastatin 40 mg Tablet2.11USD tablet
Pms-Lovastatin 40 mg Tablet2.11USD tablet
Ran-Lovastatin 40 mg Tablet2.11USD tablet
Ratio-Lovastatin 40 mg Tablet2.11USD tablet
Sandoz Lovastatin 40 mg Tablet2.11USD tablet
Mevacor 10 mg tablet1.65USD tablet
Lovastatin 10 mg tablet1.37USD tablet
Apo-Lovastatin 20 mg Tablet1.14USD tablet
Co Lovastatin 20 mg Tablet1.14USD tablet
Mylan-Lovastatin 20 mg Tablet1.14USD tablet
Novo-Lovastatin 20 mg Tablet1.14USD tablet
Pms-Lovastatin 20 mg Tablet1.14USD tablet
Ran-Lovastatin 20 mg Tablet1.14USD tablet
Ratio-Lovastatin 20 mg Tablet1.14USD tablet
Sandoz Lovastatin 20 mg Tablet1.14USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5916595 No1997-12-122017-12-12Us
US6080428 No1997-05-272017-05-27Us
US6080778 No1998-03-232018-03-23Us
US6469035 No1998-03-152018-03-15Us
US6485748 No1997-12-122017-12-12Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point174.5 °CNot Available
water solubility0.0004 mg/mLNot Available
logP4.26HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility0.0243 mg/mLALOGPS
logP4.11ALOGPS
logP3.9ChemAxon
logS-4.2ALOGPS
pKa (Strongest Acidic)14.91ChemAxon
pKa (Strongest Basic)-2.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area72.83 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity113.18 m3·mol-1ChemAxon
Polarizability46.11 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

Donald F. Gerson, Xinfa Xiao, “Process for the production of lovastatin using Coniothyrium fuckelii.” U.S. Patent US5409820, issued January, 1984.

US5409820
General References
  1. Bobek P, Ozdin L, Galbavy S: Dose- and time-dependent hypocholesterolemic effect of oyster mushroom (Pleurotus ostreatus) in rats. Nutrition. 1998 Mar;14(3):282-6. [PubMed:9583372 ]
External Links
ATC CodesC10AA02C10BA01
AHFS Codes
  • 24:06.08
PDB EntriesNot Available
FDA labelDownload (126 KB)
MSDSDownload (99.6 KB)
Interactions
Drug Interactions
Drug
1,10-PhenanthrolineThe serum concentration of Lovastatin can be increased when it is combined with 1,10-Phenanthroline.
3,4-DichloroisocoumarinThe serum concentration of Lovastatin can be increased when it is combined with 3,4-Dichloroisocoumarin.
4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDEThe serum concentration of Lovastatin can be increased when it is combined with 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE.
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Lovastatin.
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Lovastatin.
AceclofenacThe metabolism of Aceclofenac can be decreased when combined with Lovastatin.
AcenocoumarolLovastatin may increase the anticoagulant activities of Acenocoumarol.
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Lovastatin.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Lovastatin.
AcipimoxAcipimox may increase the myopathic rhabdomyolysis activities of Lovastatin.
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Lovastatin.
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Lovastatin.
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Lovastatin.
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Lovastatin.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Lovastatin.
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Lovastatin.
AlfuzosinThe metabolism of Alfuzosin can be decreased when combined with Lovastatin.
AliskirenThe metabolism of Aliskiren can be decreased when combined with Lovastatin.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Lovastatin.
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Lovastatin.
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Lovastatin.
AlogliptinThe serum concentration of Lovastatin can be increased when it is combined with Alogliptin.
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Lovastatin.
AlosetronThe metabolism of Alosetron can be decreased when combined with Lovastatin.
Alpha-1-proteinase inhibitorThe serum concentration of Lovastatin can be increased when it is combined with Alpha-1-proteinase inhibitor.
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Lovastatin.
Aluminum hydroxideThe serum concentration of Lovastatin can be decreased when it is combined with Aluminum hydroxide.
Aluminum phosphateThe serum concentration of Lovastatin can be decreased when it is combined with Aluminum phosphate.
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Lovastatin.
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Lovastatin.
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Lovastatin.
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Lovastatin.
AmiodaroneThe serum concentration of Lovastatin can be increased when it is combined with Amiodarone.
AmiodaroneThe metabolism of Amiodarone can be decreased when combined with Lovastatin.
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Lovastatin.
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Lovastatin.
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Lovastatin.
AmprenavirThe serum concentration of Lovastatin can be increased when it is combined with Amprenavir.
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Lovastatin.
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Lovastatin.
Antithrombin III humanThe serum concentration of Lovastatin can be increased when it is combined with Antithrombin III human.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Lovastatin.
ApremilastThe metabolism of Apremilast can be decreased when combined with Lovastatin.
AprepitantThe serum concentration of Lovastatin can be increased when it is combined with Aprepitant.
AprepitantThe metabolism of Aprepitant can be decreased when combined with Lovastatin.
AprotininThe serum concentration of Lovastatin can be increased when it is combined with Aprotinin.
Arachidonic AcidThe metabolism of Arachidonic Acid can be decreased when combined with Lovastatin.
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Lovastatin.
ArgatrobanThe serum concentration of Lovastatin can be increased when it is combined with Argatroban.
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Lovastatin.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Lovastatin.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Lovastatin.
ArtemetherThe metabolism of Artemether can be decreased when combined with Lovastatin.
AsenapineThe metabolism of Asenapine can be decreased when combined with Lovastatin.
AstemizoleThe metabolism of Astemizole can be decreased when combined with Lovastatin.
AsunaprevirThe serum concentration of Lovastatin can be increased when it is combined with Asunaprevir.
AtazanavirThe serum concentration of Lovastatin can be increased when it is combined with Atazanavir.
AtazanavirThe metabolism of Atazanavir can be decreased when combined with Lovastatin.
AtenololThe serum concentration of Atenolol can be increased when it is combined with Lovastatin.
AtomoxetineThe metabolism of Lovastatin can be decreased when combined with Atomoxetine.
AtorvastatinThe metabolism of Atorvastatin can be decreased when combined with Lovastatin.
AvanafilThe metabolism of Avanafil can be decreased when combined with Lovastatin.
AxitinibThe metabolism of Axitinib can be decreased when combined with Lovastatin.
AzelastineThe metabolism of Azelastine can be decreased when combined with Lovastatin.
AzithromycinAzithromycin may increase the myopathic rhabdomyolysis activities of Lovastatin.
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Lovastatin.
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Lovastatin.
BatimastatThe serum concentration of Lovastatin can be increased when it is combined with Batimastat.
BedaquilineThe metabolism of Bedaquiline can be decreased when combined with Lovastatin.
BenazeprilThe serum concentration of Lovastatin can be increased when it is combined with Benazepril.
BenzamidineThe serum concentration of Lovastatin can be increased when it is combined with Benzamidine.
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Lovastatin.
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Lovastatin.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Lovastatin.
BexaroteneThe serum concentration of Lovastatin can be decreased when it is combined with Bexarotene.
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Lovastatin.
BezafibrateBezafibrate may increase the myopathic rhabdomyolysis activities of Lovastatin.
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Lovastatin.
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Lovastatin.
Bismuth SubcitrateThe serum concentration of Lovastatin can be decreased when it is combined with Bismuth Subcitrate.
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Lovastatin.
BivalirudinThe serum concentration of Lovastatin can be increased when it is combined with Bivalirudin.
BoceprevirThe serum concentration of Lovastatin can be increased when it is combined with Boceprevir.
BoceprevirThe metabolism of Boceprevir can be decreased when combined with Lovastatin.
BortezomibThe metabolism of Lovastatin can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Lovastatin can be decreased when it is combined with Bosentan.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Lovastatin.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Lovastatin.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Lovastatin.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Lovastatin.
BrinzolamideThe metabolism of Brinzolamide can be decreased when combined with Lovastatin.
BromazepamThe metabolism of Bromazepam can be decreased when combined with Lovastatin.
BromocriptineThe metabolism of Bromocriptine can be decreased when combined with Lovastatin.
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Lovastatin.
BudesonideThe metabolism of Budesonide can be decreased when combined with Lovastatin.
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Lovastatin.
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Lovastatin.
BupropionThe metabolism of Bupropion can be decreased when combined with Lovastatin.
BuspironeThe metabolism of Buspirone can be decreased when combined with Lovastatin.
BusulfanThe metabolism of Busulfan can be decreased when combined with Lovastatin.
CabazitaxelThe metabolism of Cabazitaxel can be decreased when combined with Lovastatin.
CabergolineThe metabolism of Cabergoline can be decreased when combined with Lovastatin.
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Lovastatin.
CaffeineThe metabolism of Caffeine can be decreased when combined with Lovastatin.
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Lovastatin.
Calcium carbonateThe serum concentration of Lovastatin can be decreased when it is combined with Calcium carbonate.
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Lovastatin.
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Lovastatin.
CandesartanThe metabolism of Candesartan can be decreased when combined with Lovastatin.
CandoxatrilThe serum concentration of Lovastatin can be increased when it is combined with Candoxatril.
CaptoprilThe serum concentration of Lovastatin can be increased when it is combined with Captopril.
CarbamazepineThe metabolism of Lovastatin can be increased when combined with Carbamazepine.
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Lovastatin.
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Lovastatin.
CariprazineThe metabolism of Cariprazine can be decreased when combined with Lovastatin.
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Lovastatin.
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Lovastatin.
CeliprololThe metabolism of Celiprolol can be decreased when combined with Lovastatin.
CephalexinThe metabolism of Cephalexin can be decreased when combined with Lovastatin.
CeritinibThe serum concentration of Lovastatin can be increased when it is combined with Ceritinib.
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Lovastatin.
CevimelineThe metabolism of Cevimeline can be decreased when combined with Lovastatin.
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Lovastatin.
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Lovastatin.
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Lovastatin.
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Lovastatin.
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Lovastatin.
ChlorpropamideThe metabolism of Chlorpropamide can be decreased when combined with Lovastatin.
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Lovastatin.
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Lovastatin.
ChymostatinThe serum concentration of Lovastatin can be increased when it is combined with Chymostatin.
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Lovastatin.
CilastatinThe serum concentration of Lovastatin can be increased when it is combined with Cilastatin.
CilazaprilThe serum concentration of Lovastatin can be increased when it is combined with Cilazapril.
CilostazolThe metabolism of Cilostazol can be decreased when combined with Lovastatin.
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Lovastatin.
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Lovastatin.
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Lovastatin.
CiprofibrateThe risk or severity of adverse effects can be increased when Ciprofibrate is combined with Lovastatin.
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Lovastatin.
CisaprideThe metabolism of Cisapride can be decreased when combined with Lovastatin.
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Lovastatin.
CitalopramThe metabolism of Citalopram can be decreased when combined with Lovastatin.
ClarithromycinThe serum concentration of Lovastatin can be increased when it is combined with Clarithromycin.
ClarithromycinThe metabolism of Clarithromycin can be decreased when combined with Lovastatin.
ClemastineThe metabolism of Lovastatin can be decreased when combined with Clemastine.
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Lovastatin.
ClobazamThe metabolism of Clobazam can be decreased when combined with Lovastatin.
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Lovastatin.
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Lovastatin.
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Lovastatin.
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Lovastatin.
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Lovastatin.
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Lovastatin.
ClonidineThe metabolism of Clonidine can be decreased when combined with Lovastatin.
ClopidogrelThe metabolism of Clopidogrel can be decreased when combined with Lovastatin.
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Lovastatin.
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Lovastatin.
ClotrimazoleThe metabolism of Lovastatin can be decreased when combined with Clotrimazole.
ClozapineThe metabolism of Clozapine can be decreased when combined with Lovastatin.
CobicistatThe serum concentration of Lovastatin can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Lovastatin.
CocaineThe metabolism of Cocaine can be decreased when combined with Lovastatin.
CodeineThe metabolism of Codeine can be decreased when combined with Lovastatin.
ColchicineColchicine may increase the myopathic rhabdomyolysis activities of Lovastatin.
ColchicineThe metabolism of Colchicine can be decreased when combined with Lovastatin.
ConivaptanThe serum concentration of Lovastatin can be increased when it is combined with Conivaptan.
ConivaptanThe metabolism of Conivaptan can be decreased when combined with Lovastatin.
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be decreased when combined with Lovastatin.
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Lovastatin.
CrizotinibThe metabolism of Crizotinib can be decreased when combined with Lovastatin.
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Lovastatin.
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Lovastatin.
CyclosporineThe serum concentration of Lovastatin can be increased when it is combined with Cyclosporine.
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Lovastatin.
Cyproterone acetateThe serum concentration of Lovastatin can be increased when it is combined with Cyproterone acetate.
CytarabineThe metabolism of Cytarabine can be decreased when combined with Lovastatin.
Dabigatran etexilateThe serum concentration of Lovastatin can be increased when it is combined with Dabigatran etexilate.
DabrafenibThe serum concentration of Lovastatin can be decreased when it is combined with Dabrafenib.
DabrafenibThe metabolism of Dabrafenib can be decreased when combined with Lovastatin.
DaclatasvirThe serum concentration of Lovastatin can be increased when it is combined with Daclatasvir.
DaclatasvirThe metabolism of Daclatasvir can be decreased when combined with Lovastatin.
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Lovastatin.
DanazolThe serum concentration of Lovastatin can be increased when it is combined with Danazol.
DantroleneThe metabolism of Dantrolene can be decreased when combined with Lovastatin.
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Lovastatin.
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Lovastatin.
DapsoneThe metabolism of Dapsone can be decreased when combined with Lovastatin.
DaptomycinThe risk or severity of adverse effects can be increased when Lovastatin is combined with Daptomycin.
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Lovastatin.
DarunavirThe serum concentration of Lovastatin can be increased when it is combined with Darunavir.
DarunavirThe metabolism of Darunavir can be decreased when combined with Lovastatin.
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Lovastatin.
DasatinibThe serum concentration of Lovastatin can be increased when it is combined with Dasatinib.
DasatinibThe metabolism of Dasatinib can be decreased when combined with Lovastatin.
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Lovastatin.
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Lovastatin.
DeferasiroxThe serum concentration of Lovastatin can be decreased when it is combined with Deferasirox.
DehydroepiandrosteroneThe metabolism of Dehydroepiandrosterone can be decreased when combined with Lovastatin.
DelavirdineThe metabolism of Delavirdine can be decreased when combined with Lovastatin.
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Lovastatin.
DexamethasoneThe serum concentration of Lovastatin can be decreased when it is combined with Dexamethasone.
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Lovastatin.
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Lovastatin.
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Lovastatin.
DiazepamThe metabolism of Diazepam can be decreased when combined with Lovastatin.
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Lovastatin.
DicoumarolLovastatin may increase the anticoagulant activities of Dicoumarol.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Lovastatin.
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Lovastatin.
DigoxinThe metabolism of Digoxin can be decreased when combined with Lovastatin.
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Lovastatin.
DihydroergotamineThe metabolism of Dihydroergotamine can be decreased when combined with Lovastatin.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Lovastatin.
DiltiazemThe metabolism of Diltiazem can be decreased when combined with Lovastatin.
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Lovastatin.
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Lovastatin.
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Lovastatin.
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Lovastatin.
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Lovastatin.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Lovastatin.
DolasetronThe metabolism of Dolasetron can be decreased when combined with Lovastatin.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Lovastatin.
DonepezilThe metabolism of Donepezil can be decreased when combined with Lovastatin.
DopamineThe metabolism of Dopamine can be decreased when combined with Lovastatin.
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Lovastatin.
DoxepinThe metabolism of Doxepin can be decreased when combined with Lovastatin.
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Lovastatin.
DoxycyclineThe metabolism of Lovastatin can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Lovastatin.
DronedaroneThe metabolism of Dronedarone can be decreased when combined with Lovastatin.
DutasterideThe metabolism of Dutasteride can be decreased when combined with Lovastatin.
EcabetThe serum concentration of Lovastatin can be increased when it is combined with Ecabet.
EdoxabanThe serum concentration of Lovastatin can be increased when it is combined with Edoxaban.
EfavirenzThe serum concentration of Lovastatin can be decreased when it is combined with Efavirenz.
EfavirenzThe metabolism of Efavirenz can be decreased when combined with Lovastatin.
ElafinThe serum concentration of Lovastatin can be increased when it is combined with Elafin.
EletriptanThe metabolism of Eletriptan can be decreased when combined with Lovastatin.
EliglustatThe metabolism of Eliglustat can be decreased when combined with Lovastatin.
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Lovastatin.
EnalaprilThe serum concentration of Lovastatin can be increased when it is combined with Enalapril.
EnalaprilThe metabolism of Enalapril can be decreased when combined with Lovastatin.
EnalaprilatThe serum concentration of Lovastatin can be increased when it is combined with Enalaprilat.
EnalkirenThe serum concentration of Lovastatin can be increased when it is combined with Enalkiren.
EnzalutamideThe serum concentration of Lovastatin can be decreased when it is combined with Enzalutamide.
EnzalutamideThe metabolism of Enzalutamide can be decreased when combined with Lovastatin.
EpinastineThe metabolism of Epinastine can be decreased when combined with Lovastatin.
EplerenoneThe metabolism of Eplerenone can be decreased when combined with Lovastatin.
EpoprostenolThe metabolism of Epoprostenol can be decreased when combined with Lovastatin.
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Lovastatin.
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Lovastatin.
ErgonovineThe metabolism of Ergonovine can be decreased when combined with Lovastatin.
ErgotamineThe metabolism of Ergotamine can be decreased when combined with Lovastatin.
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Lovastatin.
ErythromycinThe serum concentration of Lovastatin can be increased when it is combined with Erythromycin.
ErythromycinThe metabolism of Erythromycin can be decreased when combined with Lovastatin.
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Lovastatin.
Eslicarbazepine acetateThe serum concentration of Lovastatin can be decreased when it is combined with Eslicarbazepine acetate.
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Lovastatin.
EstazolamThe metabolism of Estazolam can be decreased when combined with Lovastatin.
EstradiolThe metabolism of Estradiol can be decreased when combined with Lovastatin.
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Lovastatin.
EstramustineThe metabolism of Estramustine can be decreased when combined with Lovastatin.
EstriolThe serum concentration of Estriol can be increased when it is combined with Lovastatin.
EstroneThe metabolism of Estrone can be decreased when combined with Lovastatin.
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Lovastatin.
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Lovastatin.
EthanolThe metabolism of Ethanol can be decreased when combined with Lovastatin.
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Lovastatin.
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Lovastatin.
Ethyl biscoumacetateLovastatin may increase the anticoagulant activities of Ethyl biscoumacetate.
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Lovastatin.
EtodolacThe metabolism of Etodolac can be decreased when combined with Lovastatin.
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Lovastatin.
EtoposideThe metabolism of Etoposide can be decreased when combined with Lovastatin.
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Lovastatin.
EtravirineThe serum concentration of Lovastatin can be decreased when it is combined with Etravirine.
EtravirineThe metabolism of Etravirine can be decreased when combined with Lovastatin.
EverolimusThe metabolism of Everolimus can be decreased when combined with Lovastatin.
ExemestaneThe metabolism of Exemestane can be decreased when combined with Lovastatin.
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Lovastatin.
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Lovastatin.
FelbamateThe metabolism of Felbamate can be decreased when combined with Lovastatin.
FelodipineThe metabolism of Felodipine can be decreased when combined with Lovastatin.
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Lovastatin.
FenofibrateThe risk or severity of adverse effects can be increased when Fenofibrate is combined with Lovastatin.
FentanylThe metabolism of Fentanyl can be decreased when combined with Lovastatin.
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Lovastatin.
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Lovastatin.
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Lovastatin.
FinasterideThe metabolism of Finasteride can be decreased when combined with Lovastatin.
FingolimodThe metabolism of Fingolimod can be decreased when combined with Lovastatin.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Lovastatin.
FluconazoleThe serum concentration of Lovastatin can be increased when it is combined with Fluconazole.
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Lovastatin.
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Lovastatin.
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Lovastatin.
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Lovastatin.
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Lovastatin.
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Lovastatin.
FlurbiprofenThe metabolism of Flurbiprofen can be decreased when combined with Lovastatin.
FlutamideThe metabolism of Flutamide can be decreased when combined with Lovastatin.
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Lovastatin.
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be decreased when combined with Lovastatin.
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Lovastatin.
FluvoxamineThe metabolism of Lovastatin can be decreased when combined with Fluvoxamine.
FormoterolThe metabolism of Formoterol can be decreased when combined with Lovastatin.
FosamprenavirThe serum concentration of Lovastatin can be increased when it is combined with Fosamprenavir.
FosamprenavirThe metabolism of Fosamprenavir can be decreased when combined with Lovastatin.
FosaprepitantThe serum concentration of Lovastatin can be increased when it is combined with Fosaprepitant.
FosinoprilThe serum concentration of Lovastatin can be increased when it is combined with Fosinopril.
FosphenytoinThe serum concentration of Lovastatin can be decreased when it is combined with Fosphenytoin.
FosphenytoinThe metabolism of Fosphenytoin can be decreased when combined with Lovastatin.
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Lovastatin.
Fusidic AcidThe serum concentration of Lovastatin can be increased when it is combined with Fusidic Acid.
GalantamineThe metabolism of Galantamine can be decreased when combined with Lovastatin.
GavestinelThe metabolism of Gavestinel can be decreased when combined with Lovastatin.
GefitinibThe metabolism of Gefitinib can be decreased when combined with Lovastatin.
GeldanamycinThe serum concentration of Lovastatin can be increased when it is combined with Geldanamycin.
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Lovastatin.
GemfibrozilGemfibrozil may increase the myopathic rhabdomyolysis activities of Lovastatin.
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Lovastatin.
GliclazideThe metabolism of Gliclazide can be decreased when combined with Lovastatin.
GlimepirideThe metabolism of Glimepiride can be decreased when combined with Lovastatin.
GlipizideThe metabolism of Glipizide can be decreased when combined with Lovastatin.
GlyburideThe metabolism of Glyburide can be decreased when combined with Lovastatin.
GM6001The serum concentration of Lovastatin can be increased when it is combined with GM6001.
GranisetronThe metabolism of Granisetron can be decreased when combined with Lovastatin.
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Lovastatin.
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Lovastatin.
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Lovastatin.
HalofantrineThe metabolism of Halofantrine can be decreased when combined with Lovastatin.
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Lovastatin.
HalothaneThe metabolism of Halothane can be decreased when combined with Lovastatin.
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Lovastatin.
HirulogThe serum concentration of Lovastatin can be increased when it is combined with Hirulog.
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Lovastatin.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Lovastatin.
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Lovastatin.
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Lovastatin.
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Lovastatin.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Lovastatin.
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Lovastatin.
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Lovastatin.
IdelalisibThe serum concentration of Lovastatin can be increased when it is combined with Idelalisib.
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Lovastatin resulting in a loss in efficacy.
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Lovastatin.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Lovastatin.
ImatinibThe metabolism of Lovastatin can be decreased when combined with Imatinib.
ImipramineThe metabolism of Imipramine can be decreased when combined with Lovastatin.
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Lovastatin.
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Lovastatin.
IndapamideThe metabolism of Indapamide can be decreased when combined with Lovastatin.
IndinavirThe serum concentration of Lovastatin can be increased when it is combined with Indinavir.
IndinavirThe metabolism of Indinavir can be decreased when combined with Lovastatin.
indisulamThe metabolism of indisulam can be decreased when combined with Lovastatin.
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Lovastatin.
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Lovastatin.
IrbesartanThe metabolism of Irbesartan can be decreased when combined with Lovastatin.
IrinotecanThe metabolism of Irinotecan can be decreased when combined with Lovastatin.
IsavuconazoniumThe metabolism of Isavuconazonium can be decreased when combined with Lovastatin.
IsoflurophateThe serum concentration of Lovastatin can be increased when it is combined with Isoflurophate.
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Lovastatin.
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Lovastatin.
IsradipineThe metabolism of Isradipine can be decreased when combined with Lovastatin.
ItraconazoleThe serum concentration of Lovastatin can be increased when it is combined with Itraconazole.
ItraconazoleThe metabolism of Itraconazole can be decreased when combined with Lovastatin.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Lovastatin.
IvacaftorThe serum concentration of Lovastatin can be increased when it is combined with Ivacaftor.
IvacaftorThe metabolism of Ivacaftor can be decreased when combined with Lovastatin.
IvermectinThe metabolism of Ivermectin can be decreased when combined with Lovastatin.
IxabepiloneThe metabolism of Ixabepilone can be decreased when combined with Lovastatin.
IxazomibThe serum concentration of Lovastatin can be increased when it is combined with Ixazomib.
IxazomibThe metabolism of Ixazomib can be decreased when combined with Lovastatin.
KetamineThe metabolism of Ketamine can be decreased when combined with Lovastatin.
KetazolamThe metabolism of Ketazolam can be decreased when combined with Lovastatin.
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Lovastatin.
KetoconazoleThe serum concentration of Lovastatin can be increased when it is combined with Ketoconazole.
KetoconazoleThe metabolism of Ketoconazole can be decreased when combined with Lovastatin.
KetoprofenThe metabolism of Ketoprofen can be decreased when combined with Lovastatin.
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Lovastatin.
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Lovastatin.
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Lovastatin.
Lanthanum carbonateThe serum concentration of Lanthanum carbonate can be decreased when it is combined with Lovastatin.
LapatinibThe metabolism of Lapatinib can be decreased when combined with Lovastatin.
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Lovastatin.
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Lovastatin.
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Lovastatin.
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Lovastatin.
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Lovastatin.
LepirudinThe serum concentration of Lovastatin can be increased when it is combined with Lepirudin.
LercanidipineThe metabolism of Lercanidipine can be decreased when combined with Lovastatin.
LesinuradThe metabolism of Lesinurad can be decreased when combined with Lovastatin.
LetrozoleThe metabolism of Letrozole can be decreased when combined with Lovastatin.
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Lovastatin.
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Lovastatin.
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Lovastatin.
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Lovastatin.
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Lovastatin.
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Lovastatin.
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Lovastatin.
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Lovastatin.
LicofeloneThe metabolism of Licofelone can be decreased when combined with Lovastatin.
LidocaineThe metabolism of Lidocaine can be decreased when combined with Lovastatin.
LinagliptinThe serum concentration of Lovastatin can be increased when it is combined with Linagliptin.
LisinoprilThe serum concentration of Lovastatin can be increased when it is combined with Lisinopril.
LisurideThe metabolism of Lisuride can be decreased when combined with Lovastatin.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Lovastatin.
LoperamideThe metabolism of Loperamide can be decreased when combined with Lovastatin.
LopinavirThe serum concentration of Lovastatin can be increased when it is combined with Lopinavir.
LopinavirThe metabolism of Lopinavir can be decreased when combined with Lovastatin.
LoratadineThe metabolism of Loratadine can be decreased when combined with Lovastatin.
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Lovastatin.
LornoxicamThe metabolism of Lornoxicam can be decreased when combined with Lovastatin.
LosartanThe metabolism of Losartan can be decreased when combined with Lovastatin.
LuliconazoleThe serum concentration of Lovastatin can be increased when it is combined with Luliconazole.
LumefantrineThe metabolism of Lumefantrine can be decreased when combined with Lovastatin.
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Lovastatin.
LurasidoneThe metabolism of Lurasidone can be decreased when combined with Lovastatin.
MacitentanThe metabolism of Macitentan can be decreased when combined with Lovastatin.
MagaldrateThe serum concentration of Lovastatin can be decreased when it is combined with Magaldrate.
Magnesium carbonateThe serum concentration of Lovastatin can be decreased when it is combined with Magnesium carbonate.
Magnesium hydroxideThe serum concentration of Lovastatin can be decreased when it is combined with Magnesium hydroxide.
Magnesium oxideThe serum concentration of Lovastatin can be decreased when it is combined with Magnesium oxide.
Magnesium TrisilicateThe serum concentration of Lovastatin can be decreased when it is combined with Magnesium Trisilicate.
MannitolThe serum concentration of Mannitol can be increased when it is combined with Lovastatin.
MaravirocThe metabolism of Maraviroc can be decreased when combined with Lovastatin.
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Lovastatin.
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be decreased when combined with Lovastatin.
Mefenamic acidThe metabolism of Mefenamic acid can be decreased when combined with Lovastatin.
MefloquineThe metabolism of Mefloquine can be decreased when combined with Lovastatin.
MelatoninThe metabolism of Melatonin can be decreased when combined with Lovastatin.
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Lovastatin.
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Lovastatin.
MestranolThe metabolism of Mestranol can be decreased when combined with Lovastatin.
MethadoneThe metabolism of Methadone can be decreased when combined with Lovastatin.
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Lovastatin.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Lovastatin.
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Lovastatin.
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Lovastatin.
MethylprednisoloneThe metabolism of Methylprednisolone can be decreased when combined with Lovastatin.
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Lovastatin.
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Lovastatin.
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Lovastatin.
MexiletineThe metabolism of Mexiletine can be decreased when combined with Lovastatin.
MianserinThe metabolism of Mianserin can be decreased when combined with Lovastatin.
MibefradilThe metabolism of Mibefradil can be decreased when combined with Lovastatin.
MiconazoleThe metabolism of Miconazole can be decreased when combined with Lovastatin.
MidazolamThe metabolism of Midazolam can be decreased when combined with Lovastatin.
MifepristoneThe serum concentration of Lovastatin can be increased when it is combined with Mifepristone.
MifepristoneThe metabolism of Mifepristone can be decreased when combined with Lovastatin.
MirabegronThe metabolism of Mirabegron can be decreased when combined with Lovastatin.
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Lovastatin.
MitotaneThe serum concentration of Lovastatin can be decreased when it is combined with Mitotane.
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Lovastatin.
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Lovastatin.
ModafinilThe serum concentration of Lovastatin can be decreased when it is combined with Modafinil.
ModafinilThe metabolism of Modafinil can be decreased when combined with Lovastatin.
MoexiprilThe serum concentration of Lovastatin can be increased when it is combined with Moexipril.
MontelukastThe metabolism of Montelukast can be decreased when combined with Lovastatin.
MorphineThe metabolism of Morphine can be decreased when combined with Lovastatin.
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Lovastatin.
N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-ProlineThe serum concentration of Lovastatin can be increased when it is combined with N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline.
NadololThe serum concentration of Nadolol can be increased when it is combined with Lovastatin.
NafcillinThe serum concentration of Lovastatin can be decreased when it is combined with Nafcillin.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Lovastatin.
NaloxoneThe metabolism of Naloxone can be decreased when combined with Lovastatin.
NaproxenThe metabolism of Naproxen can be decreased when combined with Lovastatin.
NateglinideThe metabolism of Nateglinide can be decreased when combined with Lovastatin.
NCX 4016The serum concentration of Lovastatin can be increased when it is combined with NCX 4016.
NefazodoneThe serum concentration of Lovastatin can be increased when it is combined with Nefazodone.
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Lovastatin.
NelfinavirThe serum concentration of Lovastatin can be increased when it is combined with Nelfinavir.
NelfinavirThe metabolism of Nelfinavir can be decreased when combined with Lovastatin.
NetupitantThe serum concentration of Lovastatin can be increased when it is combined with Netupitant.
NetupitantThe metabolism of Netupitant can be decreased when combined with Lovastatin.
NevirapineThe metabolism of Nevirapine can be decreased when combined with Lovastatin.
NiacinThe risk or severity of adverse effects can be increased when Niacin is combined with Lovastatin.
NicardipineThe metabolism of Nicardipine can be decreased when combined with Lovastatin.
NiclosamideThe metabolism of Niclosamide can be decreased when combined with Lovastatin.
NicotinamideThe risk or severity of adverse effects can be increased when Nicotinamide is combined with Lovastatin.
NicotineThe metabolism of Nicotine can be decreased when combined with Lovastatin.
NifedipineThe metabolism of Nifedipine can be decreased when combined with Lovastatin.
NilotinibThe metabolism of Nilotinib can be decreased when combined with Lovastatin.
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Lovastatin.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Lovastatin.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Lovastatin.
NisoldipineThe metabolism of Nisoldipine can be decreased when combined with Lovastatin.
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Lovastatin.
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Lovastatin.
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Lovastatin.
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Lovastatin.
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Lovastatin.
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Lovastatin.
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Lovastatin.
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Lovastatin.
OlaparibThe metabolism of Lovastatin can be decreased when combined with Olaparib.
OlodaterolThe metabolism of Olodaterol can be decreased when combined with Lovastatin.
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Lovastatin.
OmapatrilatThe serum concentration of Lovastatin can be increased when it is combined with Omapatrilat.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Lovastatin.
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Lovastatin.
OndansetronThe metabolism of Ondansetron can be decreased when combined with Lovastatin.
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Lovastatin.
OsimertinibThe serum concentration of Lovastatin can be increased when it is combined with Osimertinib.
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Lovastatin.
OtamixabanThe serum concentration of Lovastatin can be increased when it is combined with Otamixaban.
OxaprozinThe metabolism of Oxaprozin can be decreased when combined with Lovastatin.
OxazepamThe metabolism of Oxazepam can be decreased when combined with Lovastatin.
OxybutyninThe metabolism of Oxybutynin can be decreased when combined with Lovastatin.
OxycodoneThe metabolism of Oxycodone can be decreased when combined with Lovastatin.
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Lovastatin.
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Lovastatin.
PalbociclibThe serum concentration of Lovastatin can be increased when it is combined with Palbociclib.
PalbociclibThe metabolism of Palbociclib can be decreased when combined with Lovastatin.
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Lovastatin.
PanobinostatThe metabolism of Panobinostat can be decreased when combined with Lovastatin.
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Lovastatin.
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Lovastatin.
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Lovastatin.
ParecoxibThe metabolism of Parecoxib can be decreased when combined with Lovastatin.
ParicalcitolThe metabolism of Paricalcitol can be decreased when combined with Lovastatin.
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Lovastatin.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Lovastatin.
PentamidineThe metabolism of Pentamidine can be decreased when combined with Lovastatin.
PentobarbitalThe metabolism of Lovastatin can be increased when combined with Pentobarbital.
PerampanelThe metabolism of Perampanel can be decreased when combined with Lovastatin.
PergolideThe metabolism of Pergolide can be decreased when combined with Lovastatin.
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Lovastatin.
PerindoprilThe serum concentration of Lovastatin can be increased when it is combined with Perindopril.
PermethrinThe metabolism of Permethrin can be decreased when combined with Lovastatin.
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Lovastatin.
PethidineThe metabolism of Pethidine can be decreased when combined with Lovastatin.
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Lovastatin.
PhenindioneLovastatin may increase the anticoagulant activities of Phenindione.
PhenobarbitalThe metabolism of Lovastatin can be increased when combined with Phenobarbital.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Lovastatin.
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Lovastatin.
PhenprocoumonLovastatin may increase the anticoagulant activities of Phenprocoumon.
PhenylbutazoneThe metabolism of Phenylbutazone can be decreased when combined with Lovastatin.
PhenytoinThe serum concentration of Lovastatin can be decreased when it is combined with Phenytoin.
PhenytoinThe metabolism of Phenytoin can be decreased when combined with Lovastatin.
PhosphoramidonThe serum concentration of Lovastatin can be increased when it is combined with Phosphoramidon.
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Lovastatin.
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Lovastatin.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Lovastatin.
PinacidilThe metabolism of Pinacidil can be decreased when combined with Lovastatin.
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Lovastatin.
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Lovastatin.
PiroxicamThe metabolism of Piroxicam can be decreased when combined with Lovastatin.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Lovastatin.
PodofiloxThe metabolism of Podofilox can be decreased when combined with Lovastatin.
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Lovastatin.
PonatinibThe metabolism of Ponatinib can be decreased when combined with Lovastatin.
PosaconazoleThe serum concentration of Lovastatin can be increased when it is combined with Posaconazole.
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Lovastatin.
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Lovastatin.
PravastatinThe metabolism of Pravastatin can be decreased when combined with Lovastatin.
PrazepamThe metabolism of Prazepam can be decreased when combined with Lovastatin.
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Lovastatin.
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Lovastatin.
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Lovastatin.
PrednisoneThe metabolism of Prednisone can be decreased when combined with Lovastatin.
PrimaquineThe metabolism of Primaquine can be decreased when combined with Lovastatin.
PrimidoneThe metabolism of Lovastatin can be increased when combined with Primidone.
PrinomastatThe serum concentration of Lovastatin can be increased when it is combined with Prinomastat.
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Lovastatin.
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Lovastatin.
ProguanilThe metabolism of Proguanil can be decreased when combined with Lovastatin.
PromazineThe metabolism of Promazine can be decreased when combined with Lovastatin.
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Lovastatin.
PropofolThe metabolism of Propofol can be decreased when combined with Lovastatin.
PropranololThe metabolism of Propranolol can be decreased when combined with Lovastatin.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Lovastatin.
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Lovastatin.
QuazepamThe metabolism of Quazepam can be decreased when combined with Lovastatin.
QuetiapineThe metabolism of Quetiapine can be decreased when combined with Lovastatin.
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Lovastatin.
QuinaprilThe serum concentration of Lovastatin can be increased when it is combined with Quinapril.
QuinidineThe metabolism of Quinidine can be decreased when combined with Lovastatin.
QuinineThe serum concentration of Lovastatin can be increased when it is combined with Quinine.
QuinineThe metabolism of Quinine can be decreased when combined with Lovastatin.
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Lovastatin.
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Lovastatin.
RaltegravirRaltegravir may increase the myopathic rhabdomyolysis activities of Lovastatin.
RamelteonThe metabolism of Ramelteon can be decreased when combined with Lovastatin.
RamiprilThe serum concentration of Lovastatin can be increased when it is combined with Ramipril.
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Lovastatin.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Lovastatin.
RanolazineRanolazine may increase the myopathic rhabdomyolysis activities of Lovastatin.
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Lovastatin.
RegorafenibThe metabolism of Regorafenib can be decreased when combined with Lovastatin.
RemikirenThe serum concentration of Lovastatin can be increased when it is combined with Remikiren.
RepaglinideThe metabolism of Repaglinide can be decreased when combined with Lovastatin.
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Lovastatin.
RetapamulinThe metabolism of Retapamulin can be decreased when combined with Lovastatin.
RifabutinThe metabolism of Lovastatin can be increased when combined with Rifabutin.
RifampicinThe metabolism of Lovastatin can be increased when combined with Rifampicin.
RifapentineThe metabolism of Lovastatin can be increased when combined with Rifapentine.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Lovastatin.
RilpivirineThe metabolism of Rilpivirine can be decreased when combined with Lovastatin.
RimonabantThe metabolism of Rimonabant can be decreased when combined with Lovastatin.
RiociguatThe metabolism of Riociguat can be decreased when combined with Lovastatin.
RisperidoneThe metabolism of Risperidone can be decreased when combined with Lovastatin.
RitonavirThe serum concentration of Lovastatin can be increased when it is combined with Ritonavir.
RitonavirThe metabolism of Ritonavir can be decreased when combined with Lovastatin.
RivaroxabanThe serum concentration of Lovastatin can be increased when it is combined with Rivaroxaban.
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Lovastatin.
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Lovastatin.
RolapitantThe metabolism of Rolapitant can be decreased when combined with Lovastatin.
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Lovastatin.
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Lovastatin.
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Lovastatin.
RosiglitazoneThe metabolism of Rosiglitazone can be decreased when combined with Lovastatin.
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Lovastatin.
RotigotineThe metabolism of Rotigotine can be decreased when combined with Lovastatin.
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Lovastatin.
RuxolitinibThe metabolism of Ruxolitinib can be decreased when combined with Lovastatin.
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Lovastatin.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Lovastatin.
SaquinavirThe serum concentration of Lovastatin can be increased when it is combined with Saquinavir.
SaquinavirThe metabolism of Saquinavir can be decreased when combined with Lovastatin.
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Lovastatin.
SelegilineThe metabolism of Selegiline can be decreased when combined with Lovastatin.
SelexipagThe metabolism of Selexipag can be decreased when combined with Lovastatin.
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Lovastatin.
SertindoleThe metabolism of Sertindole can be decreased when combined with Lovastatin.
SertralineThe metabolism of Sertraline can be decreased when combined with Lovastatin.
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Lovastatin.
SibutramineThe metabolism of Sibutramine can be decreased when combined with Lovastatin.
SildenafilThe metabolism of Sildenafil can be decreased when combined with Lovastatin.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Lovastatin.
SiltuximabThe serum concentration of Lovastatin can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Lovastatin.
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Lovastatin.
SirolimusThe metabolism of Sirolimus can be decreased when combined with Lovastatin.
SitagliptinThe serum concentration of Lovastatin can be increased when it is combined with Sitagliptin.
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Lovastatin.
SitaxentanThe metabolism of Sitaxentan can be decreased when combined with Lovastatin.
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Lovastatin.
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Lovastatin.
SonidegibThe metabolism of Sonidegib can be decreased when combined with Lovastatin.
SorafenibThe metabolism of Sorafenib can be decreased when combined with Lovastatin.
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Lovastatin.
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Lovastatin.
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Lovastatin.
SpiraprilThe serum concentration of Lovastatin can be increased when it is combined with Spirapril.
St. John's WortThe serum concentration of Lovastatin can be decreased when it is combined with St. John&#39;s Wort.
StiripentolThe serum concentration of Lovastatin can be increased when it is combined with Stiripentol.
SufentanilThe metabolism of Sufentanil can be decreased when combined with Lovastatin.
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Lovastatin.
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Lovastatin.
SulfamoxoleThe metabolism of Sulfamoxole can be decreased when combined with Lovastatin.
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Lovastatin.
SulfisoxazoleThe metabolism of Lovastatin can be decreased when combined with Sulfisoxazole.
SunitinibThe metabolism of Sunitinib can be decreased when combined with Lovastatin.
SuprofenThe metabolism of Suprofen can be decreased when combined with Lovastatin.
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Lovastatin.
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Lovastatin.
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Lovastatin.
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Lovastatin.
TadalafilThe metabolism of Tadalafil can be decreased when combined with Lovastatin.
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Lovastatin.
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Lovastatin.
TapentadolThe metabolism of Tapentadol can be decreased when combined with Lovastatin.
TasosartanThe metabolism of Tasosartan can be decreased when combined with Lovastatin.
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Lovastatin.
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Lovastatin.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Lovastatin.
TelaprevirThe serum concentration of Lovastatin can be increased when it is combined with Telaprevir.
TelaprevirThe metabolism of Telaprevir can be decreased when combined with Lovastatin.
TelithromycinThe serum concentration of Lovastatin can be increased when it is combined with Telithromycin.
TelithromycinThe metabolism of Telithromycin can be decreased when combined with Lovastatin.
TemazepamThe metabolism of Temazepam can be decreased when combined with Lovastatin.
TemocaprilThe serum concentration of Lovastatin can be increased when it is combined with Temocapril.
TemsirolimusThe metabolism of Temsirolimus can be decreased when combined with Lovastatin.
TeniposideThe metabolism of Teniposide can be decreased when combined with Lovastatin.
TenoxicamThe metabolism of Tenoxicam can be decreased when combined with Lovastatin.
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Lovastatin.
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Lovastatin.
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Lovastatin.
TestosteroneThe metabolism of Testosterone can be decreased when combined with Lovastatin.
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Lovastatin.
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Lovastatin.
TheophyllineThe metabolism of Theophylline can be decreased when combined with Lovastatin.
ThiamylalThe metabolism of Thiamylal can be decreased when combined with Lovastatin.
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Lovastatin.
ThiorphanThe serum concentration of Lovastatin can be increased when it is combined with Thiorphan.
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Lovastatin.
TiagabineThe metabolism of Tiagabine can be decreased when combined with Lovastatin.
TicagrelorThe serum concentration of Lovastatin can be increased when it is combined with Ticagrelor.
TicagrelorThe metabolism of Ticagrelor can be decreased when combined with Lovastatin.
TiclopidineThe metabolism of Lovastatin can be decreased when combined with Ticlopidine.
TimololThe serum concentration of Timolol can be increased when it is combined with Lovastatin.
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Lovastatin.
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Lovastatin.
TipranavirThe serum concentration of Lovastatin can be increased when it is combined with Tipranavir.
TipranavirThe metabolism of Tipranavir can be decreased when combined with Lovastatin.
TocilizumabThe serum concentration of Lovastatin can be decreased when it is combined with Tocilizumab.
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Lovastatin.
TolbutamideThe metabolism of Tolbutamide can be decreased when combined with Lovastatin.
TolterodineThe metabolism of Tolterodine can be decreased when combined with Lovastatin.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Lovastatin.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Lovastatin.
TorasemideThe metabolism of Torasemide can be decreased when combined with Lovastatin.
ToremifeneThe metabolism of Toremifene can be decreased when combined with Lovastatin.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Lovastatin.
TramadolThe metabolism of Tramadol can be decreased when combined with Lovastatin.
TrandolaprilThe serum concentration of Lovastatin can be increased when it is combined with Trandolapril.
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be decreased when combined with Lovastatin.
TrazodoneThe metabolism of Trazodone can be decreased when combined with Lovastatin.
TreprostinilThe metabolism of Treprostinil can be decreased when combined with Lovastatin.
TretinoinThe metabolism of Tretinoin can be decreased when combined with Lovastatin.
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Lovastatin.
TriazolamThe metabolism of Triazolam can be decreased when combined with Lovastatin.
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Lovastatin.
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Lovastatin.
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Lovastatin.
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Lovastatin.
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Lovastatin.
UbenimexThe serum concentration of Lovastatin can be increased when it is combined with Ubenimex.
UdenafilThe metabolism of Udenafil can be decreased when combined with Lovastatin.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Lovastatin.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Lovastatin.
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Lovastatin.
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Lovastatin.
ValsartanThe metabolism of Valsartan can be decreased when combined with Lovastatin.
VandetanibThe metabolism of Vandetanib can be decreased when combined with Lovastatin.
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Lovastatin.
VardenafilThe metabolism of Vardenafil can be decreased when combined with Lovastatin.
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Lovastatin.
VemurafenibThe metabolism of Vemurafenib can be decreased when combined with Lovastatin.
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Lovastatin.
VerapamilThe metabolism of Verapamil can be decreased when combined with Lovastatin.
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Lovastatin.
VilanterolThe metabolism of Vilanterol can be decreased when combined with Lovastatin.
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Lovastatin.
VildagliptinThe serum concentration of Lovastatin can be increased when it is combined with Vildagliptin.
VinblastineThe metabolism of Vinblastine can be decreased when combined with Lovastatin.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Lovastatin.
VindesineThe serum concentration of Vindesine can be increased when it is combined with Lovastatin.
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Lovastatin.
VismodegibThe metabolism of Vismodegib can be decreased when combined with Lovastatin.
VoriconazoleThe serum concentration of Lovastatin can be increased when it is combined with Voriconazole.
VoriconazoleThe metabolism of Voriconazole can be decreased when combined with Lovastatin.
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Lovastatin.
WarfarinLovastatin may increase the anticoagulant activities of Warfarin.
XimelagatranThe serum concentration of Lovastatin can be increased when it is combined with Ximelagatran.
XimelagatranThe metabolism of Ximelagatran can be decreased when combined with Lovastatin.
YohimbineThe metabolism of Yohimbine can be decreased when combined with Lovastatin.
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Lovastatin.
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Lovastatin.
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Lovastatin.
ZaltoprofenThe metabolism of Zaltoprofen can be decreased when combined with Lovastatin.
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Lovastatin.
ZileutonThe metabolism of Zileuton can be decreased when combined with Lovastatin.
ZiprasidoneThe metabolism of Ziprasidone can be decreased when combined with Lovastatin.
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Lovastatin.
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Lovastatin.
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Lovastatin.
ZopicloneThe metabolism of Zopiclone can be decreased when combined with Lovastatin.
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Lovastatin.
Food Interactions
  • Avoid alcohol.
  • Avoid drastic changes in dietary habit.
  • Avoid taking with grapefruit juice.
  • Take with food, 50% increase in bioavailability when taken with food.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Nadph binding
Specific Function:
Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
Gene Name:
HMGCR
Uniprot ID:
P04035
Molecular Weight:
97475.155 Da
References
  1. Abe Y, Suzuki T, Ono C, Iwamoto K, Hosobuchi M, Yoshikawa H: Molecular cloning and characterization of an ML-236B (compactin) biosynthetic gene cluster in Penicillium citrinum. Mol Genet Genomics. 2002 Jul;267(5):636-46. Epub 2002 Jun 28. [PubMed:12172803 ]
  2. Miyazaki A, Koieyama T, Shimada Y, Kikuchi T, Nezu H, Ito K, Kasanuki N, Koga T: Effects of pravastatin sodium on mevalonate metabolism in common marmosets. J Biochem. 2002 Sep;132(3):395-400. [PubMed:12204108 ]
  3. Buxbaum JD, Geoghagen NS, Friedhoff LT: Cholesterol depletion with physiological concentrations of a statin decreases the formation of the Alzheimer amyloid Abeta peptide. J Alzheimers Dis. 2001 Apr;3(2):221-229. [PubMed:12214063 ]
  4. Baranova NA, Kreier VG, Egorov NS: [Concentration on Diapak C 16 capsules of lovastatin, mevinolinic acid and other inhibitors of biosynthesis of sterins produced by Penicillium citrinum 89]. Antibiot Khimioter. 2002;47(4):3-6. [PubMed:12369143 ]
  5. Farina HG, Bublik DR, Alonso DF, Gomez DE: Lovastatin alters cytoskeleton organization and inhibits experimental metastasis of mammary carcinoma cells. Clin Exp Metastasis. 2002;19(6):551-9. [PubMed:12405293 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  7. Podar K, Tai YT, Hideshima T, Vallet S, Richardson PG, Anderson KC: Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. doi: 10.1517/14728210802676278 . [PubMed:19249983 ]
  8. Dimitroulakos J, Marhin WH, Tokunaga J, Irish J, Gullane P, Penn LZ, Kamel-Reid S: Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas. Neoplasia. 2002 Jul-Aug;4(4):337-46. [PubMed:12082550 ]
Kind
Protein
Organism
Human
Pharmacological action
no
Actions
other/unknown
General Function:
Metal ion binding
Specific Function:
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
Gene Name:
ITGAL
Uniprot ID:
P20701
Molecular Weight:
128768.495 Da
References
  1. Kallen J, Welzenbach K, Ramage P, Geyl D, Kriwacki R, Legge G, Cottens S, Weitz-Schmidt G, Hommel U: Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain. J Mol Biol. 1999 Sep 10;292(1):1-9. [PubMed:10493852 ]
Kind
Protein
Organism
Human
Pharmacological action
no
Actions
other
General Function:
Transcription factor binding
Specific Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor c...
Gene Name:
HDAC2
Uniprot ID:
Q92769
Molecular Weight:
55363.855 Da
References
  1. Lin YC, Lin JH, Chou CW, Chang YF, Yeh SH, Chen CC: Statins increase p21 through inhibition of histone deacetylase activity and release of promoter-associated HDAC1/2. Cancer Res. 2008 Apr 1;68(7):2375-83. doi: 10.1158/0008-5472.CAN-07-5807. [PubMed:18381445 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Neuvonen PJ, Niemi M, Backman JT: Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance. Clin Pharmacol Ther. 2006 Dec;80(6):565-81. [PubMed:17178259 ]
  2. Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH: Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. [PubMed:11523064 ]
  3. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  4. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  5. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Protein homodimerization activity
Specific Function:
Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.
Gene Name:
PON3
Uniprot ID:
Q15166
Molecular Weight:
39607.185 Da
References
  1. Draganov DI, Stetson PL, Watson CE, Billecke SS, La Du BN: Rabbit serum paraoxonase 3 (PON3) is a high density lipoprotein-associated lactonase and protects low density lipoprotein against oxidation. J Biol Chem. 2000 Oct 27;275(43):33435-42. [PubMed:10931838 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Tornio A, Pasanen MK, Laitila J, Neuvonen PJ, Backman JT: Comparison of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) as inhibitors of cytochrome P450 2C8. Basic Clin Pharmacol Toxicol. 2005 Aug;97(2):104-8. [PubMed:15998357 ]
  2. Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. [PubMed:15601807 ]
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH: Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. [PubMed:11523064 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH: Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. [PubMed:11523064 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid binding
Specific Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naph...
Gene Name:
UGT1A1
Uniprot ID:
P22309
Molecular Weight:
59590.91 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Retinoic acid binding
Specific Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.
Gene Name:
UGT1A3
Uniprot ID:
P35503
Molecular Weight:
60337.835 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Glucuronosyltransferase activity
Specific Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol...
Gene Name:
UGT2B7
Uniprot ID:
P16662
Molecular Weight:
60694.12 Da
References
  1. Prueksaritanont T, Subramanian R, Fang X, Ma B, Qiu Y, Lin JH, Pearson PG, Baillie TA: Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization. Drug Metab Dispos. 2002 May;30(5):505-12. [PubMed:11950779 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Wang E, Casciano CN, Clement RP, Johnson WW: HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein. Pharm Res. 2001 Jun;18(6):800-6. [PubMed:11474784 ]
  2. Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. [PubMed:11716514 ]
  3. Kim RB, Wandel C, Leake B, Cvetkovic M, Fromm MF, Dempsey PJ, Roden MM, Belas F, Chaudhary AK, Roden DM, Wood AJ, Wilkinson GR: Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Pharm Res. 1999 Mar;16(3):408-14. [PubMed:10213372 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. [PubMed:10421612 ]
  2. Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP, Kirchgessner TG: A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem. 1999 Dec 24;274(52):37161-8. [PubMed:10601278 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B1
Uniprot ID:
Q9Y6L6
Molecular Weight:
76447.99 Da
References
  1. Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP, Kirchgessner TG: A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem. 1999 Dec 24;274(52):37161-8. [PubMed:10601278 ]
  2. Sandhu P, Lee W, Xu X, Leake BF, Yamazaki M, Stone JA, Lin JH, Pearson PG, Kim RB: Hepatic uptake of the novel antifungal agent caspofungin. Drug Metab Dispos. 2005 May;33(5):676-82. Epub 2005 Feb 16. [PubMed:15716364 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Organic anion transmembrane transporter activity
Specific Function:
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Gene Name:
ABCC2
Uniprot ID:
Q92887
Molecular Weight:
174205.64 Da
References
  1. Ellis LC, Hawksworth GM, Weaver RJ: ATP-dependent transport of statins by human and rat MRP2/Mrp2. Toxicol Appl Pharmacol. 2013 Jun 1;269(2):187-94. doi: 10.1016/j.taap.2013.03.019. Epub 2013 Apr 2. [PubMed:23562342 ]
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Drug created on June 13, 2005 07:24 / Updated on September 24, 2016 02:15