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Identification
NameAlclometasone
Accession NumberDB00240  (APRD00783)
Typesmall molecule
Groupsapproved
Description

Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent. [Wikipedia]

Structure
Thumb
Synonyms
SynonymLanguageCode
7alpha-Chloro-16alpha-methylprednisoloneNot AvailableNot Available
7α-Chloro-16α-methylprednisoloneNot AvailableNot Available
AclometasoneNot AvailableNot Available
Salts
Name/CAS Structure Properties
Alclometasone dipropionate
Thumb Not applicable DBSALT000893
Brand names
NameCompany
AclovateNot Available
Brand mixturesNot Available
Categories
CAS number66734-13-2
WeightAverage: 408.916
Monoisotopic: 408.170351745
Chemical FormulaC22H29ClO5
InChI KeyFJXOGVLKCZQRDN-PHCHRAKRSA-N
InChI
InChI=1S/C22H29ClO5/c1-11-6-14-18-15(23)8-12-7-13(25)4-5-20(12,2)19(18)16(26)9-21(14,3)22(11,28)17(27)10-24/h4-5,7,11,14-16,18-19,24,26,28H,6,8-10H2,1-3H3/t11-,14+,15-,16+,18-,19+,20+,21+,22+/m1/s1
IUPAC Name
(1S,2R,9R,10S,11S,13R,14R,15S,17S)-9-chloro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one
SMILES
[H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])[C@H](Cl)CC2=CC(=O)C=C[C@]12C
Mass SpecNot Available
Taxonomy
KingdomOrganic Compounds
SuperclassLipids
ClassSteroids and Steroid Derivatives
SubclassGluco/mineralocorticoids, Progestogins and Derivatives
Direct parentGluco/mineralocorticoids, Progestogins and Derivatives
Alternative parentsKetosteroids; Hydroxysteroids; Halogenated Steroids; Iridoids and Derivatives; Cyclohexanols; Tertiary Alcohols; Ketones; Cyclic Alcohols and Derivatives; Enolates; Polyamines; Primary Alcohols; Organochlorides; Alkyl Chlorides; Aldehydes
Substituents11-hydroxy-steroid; 7-halo-steroid; 17-hydroxy-steroid; 3-keto-steroid; 20-keto-steroid; monoterpene; 11-noriridane monoterpene; cyclohexanol; tertiary alcohol; cyclic alcohol; secondary alcohol; ketone; polyamine; enolate; primary alcohol; organochloride; organohalogen; alcohol; carbonyl group; alkyl halide; alkyl chloride; aldehyde
Classification descriptionThis compound belongs to the gluco/mineralocorticoids, progestogins and derivatives. These are steroids whose structure is based on an hydroxylated prostane moiety.
Pharmacology
IndicationFor the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
PharmacodynamicsAlclometasone is a synthetic corticosteroid for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory and antipruritic agents. Alclometasone is a selective glucocorticoid receptor agonist.
Mechanism of actionThe mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. Alclometasone initially binds the corticosteroid receptor. This complex migrates to the nucleus where it binds to different glucocorticoid response elements on the DNA. This in turn enhances and represses various genes, especially those involved in inflammatory pathways.
AbsorptionTopical corticosteroids can be absorbed from normal intact skin. Studies have shown that approximately 3% of steroid is absorbed during 8 hours of contact with intact skin of normal volunteers.
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Hepatic.

Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicitySymptoms of overdose include suppression of adrenal glands, temporary decrease in white blood cell counts, symptoms of hypersensitivity (such as skin rash, hives, itching, and difficulty breathing), and increased susceptibility to infection.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
Property Value Probability
Human Intestinal Absorption + 0.9948
Blood Brain Barrier + 0.9518
Caco-2 permeable + 0.6337
P-glycoprotein substrate Substrate 0.7572
P-glycoprotein inhibitor I Non-inhibitor 0.8049
P-glycoprotein inhibitor II Non-inhibitor 0.8763
Renal organic cation transporter Non-inhibitor 0.8262
CYP450 2C9 substrate Non-substrate 0.8524
CYP450 2D6 substrate Non-substrate 0.9027
CYP450 3A4 substrate Substrate 0.717
CYP450 1A2 substrate Non-inhibitor 0.9228
CYP450 2C9 substrate Non-inhibitor 0.9215
CYP450 2D6 substrate Non-inhibitor 0.9372
CYP450 2C19 substrate Non-inhibitor 0.8962
CYP450 3A4 substrate Non-inhibitor 0.7736
CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.8568
Ames test Non AMES toxic 0.8448
Carcinogenicity Non-carcinogens 0.9132
Biodegradation Not ready biodegradable 0.9974
Rat acute toxicity 2.2398 LD50, mol/kg Not applicable
hERG inhibition (predictor I) Weak inhibitor 0.9651
hERG inhibition (predictor II) Non-inhibitor 0.6522
Pharmacoeconomics
Manufacturers
  • Nycomed us inc
  • Altana inc
  • Glenmark generics ltd
  • Taro pharmaceuticals usa inc
  • Glaxosmithkline
Packagers
Dosage forms
FormRouteStrength
CreamTopical
OintmentTopical
Prices
Unit descriptionCostUnit
Aclovate 0.05% Ointment 60 gm Tube141.1USDtube
Aclovate 0.05% Cream 60 gm Tube103.1USDtube
Aclovate 0.05% Cream 45 gm Tube81.19USDtube
Aclovate 0.05% Cream 15 gm Tube54.54USDtube
Aclovate 0.05% Ointment 15 gm Tube52.99USDtube
Alclometasone Dipropionate 0.05% Cream 60 gm Tube52.99USDtube
Alclometasone Dipropionate 0.05% Cream 45 gm Tube41.31USDtube
Alclometasone Dipropionate 0.05% Ointment 60 gm Tube39.27USDtube
Alclometasone Dipropionate 0.05% Cream 15 gm Tube19.81USDtube
Alclometasone Dipropionate 0.05% Ointment 15 gm Tube16.99USDtube
Aclovate 0.05% cream2.91USDg
Alclometasone dipro 0.05% crm1.21USDg
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
Statesolid
Experimental Properties
PropertyValueSource
water solubilityInsolubleNot Available
logP2.7Not Available
Predicted Properties
PropertyValueSource
water solubility1.37e-01 g/lALOGPS
logP2.11ALOGPS
logP1.68ChemAxon
logS-3.5ALOGPS
pKa (strongest acidic)12.45ChemAxon
pKa (strongest basic)-2.9ChemAxon
physiological charge0ChemAxon
hydrogen acceptor count5ChemAxon
hydrogen donor count3ChemAxon
polar surface area94.83ChemAxon
rotatable bond count2ChemAxon
refractivity107.61ChemAxon
polarizability42.62ChemAxon
number of rings4ChemAxon
bioavailability1ChemAxon
rule of fiveYesChemAxon
Ghose filterYesChemAxon
Veber's ruleNoChemAxon
MDDR-like ruleNoChemAxon
Spectra
SpectraNot Available
References
Synthesis ReferenceNot Available
General ReferenceNot Available
External Links
ResourceLink
KEGG DrugD01820
ChEBI53776
ChEMBLCHEMBL1201361
Therapeutic Targets DatabaseDAP000415
PharmGKBPA164747650
RxListhttp://www.rxlist.com/cgi/generic3/alclometasone.htm
Drugs.comhttp://www.drugs.com/cdi/alclometasone-cream.html
PDRhealthhttp://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/acl1005.shtml
WikipediaAlclometasone
ATC CodesD07AB10S01BA10
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelshow(191 KB)
MSDSshow(26.3 KB)
Interactions
Drug InteractionsNot Available
Food InteractionsNot Available

Targets

1. Glucocorticoid receptor

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: agonist

Components

Name UniProt ID Details
Glucocorticoid receptor P04150 Details

References:

  1. Labeur M, Holsboer F: Molecular mechanisms of glucocorticoid receptor signaling. Medicina (B Aires). 2010;70(5):457-462. Pubmed
  2. Hofmann TG, Hehner SP, Bacher S, Droge W, Schmitz ML: Various glucocorticoids differ in their ability to induce gene expression, apoptosis and to repress NF-kappaB-dependent transcription. FEBS Lett. 1998 Dec 28;441(3):441-6. Pubmed

Enzymes

1. Cytochrome P450 3A4

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inducer

Components

Name UniProt ID Details
Cytochrome P450 3A4 P08684 Details

References:

  1. El-Sankary W, Bombail V, Gibson GG, Plant N: Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element. Drug Metab Dispos. 2002 Sep;30(9):1029-34. Pubmed
  2. Cooper BW, Cho TM, Thompson PM, Wallace AD: Phthalate induction of CYP3A4 is dependent on glucocorticoid regulation of PXR expression. Toxicol Sci. 2008 Jun;103(2):268-77. Epub 2008 Mar 10. Pubmed

Carriers

1. Corticosteroid-binding globulin

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: binder

Components

Name UniProt ID Details
Corticosteroid-binding globulin P08185 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed

Comments
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Drug created on June 13, 2005 07:24 / Updated on September 16, 2013 17:08