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Identification
NameRanolazine
Accession NumberDB00243  (APRD01300)
TypeSmall Molecule
GroupsApproved, Investigational
DescriptionRanolazine is an antianginal medication. On January 31, 2006, ranolazine was approved for use in the United States by the FDA for the treatment of chronic angina. [Wikipedia]
Structure
Thumb
SynonymsNot Available
External Identifiers
  • CVT-303
  • RS-43285-003
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ranexatablet, film coated, extended release500 mg/1oralCardinal Health2007-02-12Not applicableUs
Ranexatablet, film coated, extended release500 mg/1oralGilead Sciences, Inc.2006-01-27Not applicableUs
Ranexatablet, film coated, extended release500 mg/1oralCardinal Health2006-01-27Not applicableUs
Ranexatablet, film coated, extended release1000 mg/1oralGilead Sciences, Inc.2007-02-12Not applicableUs
Ranexatablet, film coated, extended release500 mg/1oralGilead Sciences, Inc.2006-01-27Not applicableUs
Ranexatablet, film coated, extended release500 mg/1oralCarilion Materials Management2006-01-27Not applicableUs
Ranexatablet, film coated, extended release1000 mg/1oralGilead Sciences, Inc.2007-02-12Not applicableUs
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Ranolazine hydrochloride
95635-56-6
Thumb
  • InChI Key: RJNSNFZXAZXOFX-UHFFFAOYSA-N
  • Monoisotopic Mass: 499.200462037
  • Average Mass: 500.458
DBSALT000388
Categories
UNIIA6IEZ5M406
CAS number95635-55-5
WeightAverage: 427.5365
Monoisotopic: 427.247106559
Chemical FormulaC24H33N3O4
InChI KeyInChIKey=XKLMZUWKNUAPSZ-UHFFFAOYSA-N
InChI
InChI=1S/C24H33N3O4/c1-18-7-6-8-19(2)24(18)25-23(29)16-27-13-11-26(12-14-27)15-20(28)17-31-22-10-5-4-9-21(22)30-3/h4-10,20,28H,11-17H2,1-3H3,(H,25,29)
IUPAC Name
N-(2,6-dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetamide
SMILES
COC1=CC=CC=C1OCC(O)CN1CCN(CC(=O)NC2=C(C)C=CC=C2C)CC1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as alpha amino acid amides. These are amide derivatives of alpha amino acids.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentAlpha amino acid amides
Alternative Parents
Substituents
  • Alpha-amino acid amide
  • N-arylamide
  • N-piperazineacetamide
  • Methoxybenzene
  • Phenol ether
  • Anisole
  • N-alkylpiperazine
  • Alkyl aryl ether
  • Benzenoid
  • Piperazine
  • 1,4-diazinane
  • Monocyclic benzene moiety
  • Tertiary aliphatic amine
  • Tertiary amine
  • Secondary carboxylic acid amide
  • Secondary alcohol
  • Carboxamide group
  • 1,2-aminoalcohol
  • Azacycle
  • Organoheterocyclic compound
  • Ether
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Alcohol
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor the treatment of chronic angina. It should be used in combination with amlodipine, beta-blockers or nitrates.
PharmacodynamicsRanolazine has antianginal and anti-ischemic effects that do not depend upon reductions in heart rate or blood pressure. It is the first new anti-anginal developed in over 20 years.
Mechanism of actionThe mechanism of action of ranolazine is unknown. It does not increase the rate-pressure product, a measure of myocardial work, at maximal exercise. In vitro studies suggest that ranolazine is a P-gp inhibitor. Ranolazine is believed to have its effects via altering the trans-cellular late sodium current. It is by altering the intracellular sodium level that ranolazine affects the sodium-dependent calcium channels during myocardial ischemia. Thus, ranolazine indirectly prevents the calcium overload that causes cardiac ischemia.
Related Articles
AbsorptionAbsorption is highly variable. After oral administration of ranolazine as a solution, 73% of the dose is systemically available as ranolazine or metabolites. The bioavailability of oral ranolazine relative to that from a solution is 76%.
Volume of distributionNot Available
Protein binding62%
Metabolism

Hepatic, metabolized mainly by CYP3A and to a lesser extent by CYP2D6. The pharmacologic activity of the metabolites has not been well characterized.

Route of eliminationRanolazine is metabolized rapidly and extensively in the liver and intestine; less than 5% is excreted unchanged in urine and feces.
Half life7 hours
ClearanceNot Available
ToxicityIn the event of overdose, the expected symptoms would be dizziness, nausea/vomiting, diplopia, paresthesia, and confusion. Syncope with prolonged loss of consciousness may develop.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption-0.7425
Blood Brain Barrier-0.5334
Caco-2 permeable-0.5853
P-glycoprotein substrateSubstrate0.8667
P-glycoprotein inhibitor IInhibitor0.7566
P-glycoprotein inhibitor IIInhibitor0.7524
Renal organic cation transporterNon-inhibitor0.7648
CYP450 2C9 substrateNon-substrate0.7965
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.7456
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.907
CYP450 2D6 inhibitorNon-inhibitor0.8287
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.8309
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8155
Ames testNon AMES toxic0.8529
CarcinogenicityNon-carcinogens0.9128
BiodegradationNot ready biodegradable0.9936
Rat acute toxicity2.3256 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8753
hERG inhibition (predictor II)Inhibitor0.8775
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Gilead sciences inc
Packagers
Dosage forms
FormRouteStrength
Tablet, film coated, extended releaseoral1000 mg/1
Tablet, film coated, extended releaseoral500 mg/1
Prices
Unit descriptionCostUnit
Ranexa 1000 mg 12 Hour tablet6.89USD tablet
Ranexa 1000 mg tablet6.63USD tablet
Ranexa 500 mg 12 Hour tablet4.06USD tablet
Ranexa 500 mg tablet4.04USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6303607 No1999-05-272019-05-27Us
US6369062 No1999-05-272019-05-27Us
US6479496 No1999-05-272019-05-27Us
US6503911 No1999-05-272019-05-27Us
US6525057 No1999-05-272019-05-27Us
US6562826 No1999-05-272019-05-27Us
US6617328 No1999-05-272019-05-27Us
US6620814 No1999-05-272019-05-27Us
US6852724 No1999-05-272019-05-27Us
US6864258 No1999-05-272019-05-27Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
water solubilityVery slightly solubleNot Available
logP1.6Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.11 mg/mLALOGPS
logP2.08ALOGPS
logP2.83ChemAxon
logS-3.6ALOGPS
pKa (Strongest Acidic)13.6ChemAxon
pKa (Strongest Basic)7.17ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area74.27 Å2ChemAxon
Rotatable Bond Count9ChemAxon
Refractivity123.46 m3·mol-1ChemAxon
Polarizability47.22 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

Raghupathi Reddy Anumula, Goverdhan Gilla, Sampath Aalla, Lokeswara Rao Madivada, Prabhaker Macherla, Srinivas Kurella, Kavitha Charagondla, Ramamurthy Kasula, Rajagopala Rao Mandadapu, Krishaniah Charagondla, Malati Vakamulla, Durga Prasad Janaki Bhavanipurapu, “PREPARATION OF RANOLAZINE.” U.S. Patent US20110151258, issued June 23, 2011.

US20110151258
General References
  1. Hale SL, Kloner RA: Ranolazine, an inhibitor of the late sodium channel current, reduces postischemic myocardial dysfunction in the rabbit. J Cardiovasc Pharmacol Ther. 2006 Dec;11(4):249-55. [PubMed:17220471 ]
  2. Fraser H, Belardinelli L, Wang L, Light PE, McVeigh JJ, Clanachan AS: Ranolazine decreases diastolic calcium accumulation caused by ATX-II or ischemia in rat hearts. J Mol Cell Cardiol. 2006 Dec;41(6):1031-8. Epub 2006 Oct 5. [PubMed:17027025 ]
  3. Stone PH, Gratsiansky NA, Blokhin A, Huang IZ, Meng L: Antianginal efficacy of ranolazine when added to treatment with amlodipine: the ERICA (Efficacy of Ranolazine in Chronic Angina) trial. J Am Coll Cardiol. 2006 Aug 1;48(3):566-75. Epub 2006 Jun 15. [PubMed:16875985 ]
  4. Chaitman BR, Pepine CJ, Parker JO, Skopal J, Chumakova G, Kuch J, Wang W, Skettino SL, Wolff AA: Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial. JAMA. 2004 Jan 21;291(3):309-16. [PubMed:14734593 ]
  5. Morrow DA, Scirica BM, Karwatowska-Prokopczuk E, Murphy SA, Budaj A, Varshavsky S, Wolff AA, Skene A, McCabe CH, Braunwald E: Effects of ranolazine on recurrent cardiovascular events in patients with non-ST-elevation acute coronary syndromes: the MERLIN-TIMI 36 randomized trial. JAMA. 2007 Apr 25;297(16):1775-83. [PubMed:17456819 ]
External Links
ATC CodesC01EB18
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelDownload (203 KB)
MSDSNot Available
Interactions
Drug Interactions
Drug
2-HYDROXY-1,4-NAPHTHOQUINONEThe metabolism of Ranolazine can be decreased when combined with 2-HYDROXY-1,4-NAPHTHOQUINONE.
2-mercaptobenzothiazoleThe metabolism of Ranolazine can be decreased when combined with 2-mercaptobenzothiazole.
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Ranolazine.
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Ranolazine.
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Ranolazine.
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Ranolazine.
AcetaminophenThe serum concentration of Ranolazine can be increased when it is combined with Acetaminophen.
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Ranolazine.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Ranolazine.
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Ranolazine.
AfatinibThe serum concentration of Ranolazine can be increased when it is combined with Afatinib.
AjmalineThe metabolism of Ajmaline can be decreased when combined with Ranolazine.
AlbendazoleThe serum concentration of Ranolazine can be increased when it is combined with Albendazole.
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Ranolazine.
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Ranolazine.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Ranolazine.
AlectinibThe serum concentration of Ranolazine can be increased when it is combined with Alectinib.
AlfentanilThe serum concentration of Ranolazine can be increased when it is combined with Alfentanil.
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Ranolazine.
AlfuzosinThe metabolism of Alfuzosin can be decreased when combined with Ranolazine.
AliskirenThe metabolism of Aliskiren can be decreased when combined with Ranolazine.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Ranolazine.
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Ranolazine.
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Ranolazine.
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Ranolazine.
AlosetronThe metabolism of Alosetron can be decreased when combined with Ranolazine.
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Ranolazine.
AlprenololThe metabolism of Alprenolol can be decreased when combined with Ranolazine.
AmantadineThe serum concentration of Ranolazine can be increased when it is combined with Amantadine.
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Ranolazine.
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Ranolazine.
Aminohippuric acidThe serum concentration of Ranolazine can be increased when it is combined with Aminohippuric acid.
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Ranolazine.
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Ranolazine.
AmiodaroneThe serum concentration of Ranolazine can be increased when it is combined with Amiodarone.
AmiodaroneThe metabolism of Amiodarone can be decreased when combined with Ranolazine.
AmitriptylineThe serum concentration of Ranolazine can be increased when it is combined with Amitriptyline.
AmlodipineThe serum concentration of Ranolazine can be increased when it is combined with Amlodipine.
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Ranolazine.
AmorolfineThe metabolism of Ranolazine can be decreased when combined with Amorolfine.
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Ranolazine.
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Ranolazine.
Amphotericin BThe metabolism of Ranolazine can be decreased when combined with Amphotericin B.
AmprenavirThe serum concentration of Ranolazine can be increased when it is combined with Amprenavir.
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Ranolazine.
AmsacrineThe serum concentration of Ranolazine can be increased when it is combined with Amsacrine.
AmsacrineThe metabolism of Amsacrine can be decreased when combined with Ranolazine.
AN2690The metabolism of Ranolazine can be decreased when combined with AN2690.
AnagrelideRanolazine may increase the QTc-prolonging activities of Anagrelide.
AnidulafunginThe metabolism of Ranolazine can be decreased when combined with Anidulafungin.
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Ranolazine.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Ranolazine.
ApremilastThe metabolism of Apremilast can be decreased when combined with Ranolazine.
AprepitantThe serum concentration of Ranolazine can be increased when it is combined with Aprepitant.
AprepitantThe metabolism of Aprepitant can be decreased when combined with Ranolazine.
AprindineThe metabolism of Aprindine can be decreased when combined with Ranolazine.
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Ranolazine.
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Ranolazine.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Ranolazine.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Ranolazine.
ArtemetherThe metabolism of Ranolazine can be decreased when combined with Artemether.
AsenapineThe metabolism of Asenapine can be decreased when combined with Ranolazine.
AstemizoleThe serum concentration of Ranolazine can be increased when it is combined with Astemizole.
AstemizoleThe metabolism of Astemizole can be decreased when combined with Ranolazine.
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Ranolazine.
AtenololThe serum concentration of Ranolazine can be increased when it is combined with Atenolol.
AtomoxetineThe metabolism of Ranolazine can be decreased when combined with Atomoxetine.
AtorvastatinThe serum concentration of Ranolazine can be increased when it is combined with Atorvastatin.
AvanafilThe metabolism of Avanafil can be decreased when combined with Ranolazine.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Ranolazine.
AzelastineThe serum concentration of Ranolazine can be increased when it is combined with Azelastine.
AzelastineThe metabolism of Azelastine can be decreased when combined with Ranolazine.
AzithromycinThe serum concentration of Ranolazine can be increased when it is combined with Azithromycin.
AzithromycinRanolazine may increase the QTc-prolonging activities of Azithromycin.
Bafilomycin A1The metabolism of Ranolazine can be decreased when combined with Bafilomycin A1.
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Ranolazine.
BedaquilineRanolazine may increase the QTc-prolonging activities of Bedaquiline.
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Ranolazine.
BenzocaineThe serum concentration of Ranolazine can be increased when it is combined with Benzocaine.
Benzoic AcidThe metabolism of Ranolazine can be decreased when combined with Benzoic Acid.
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Ranolazine.
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Ranolazine.
BepridilThe serum concentration of Ranolazine can be increased when it is combined with Bepridil.
BepridilThe metabolism of Bepridil can be decreased when combined with Ranolazine.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Ranolazine.
BetaxololThe metabolism of Betaxolol can be decreased when combined with Ranolazine.
BexaroteneThe serum concentration of Ranolazine can be decreased when it is combined with Bexarotene.
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Ranolazine.
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Ranolazine.
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Ranolazine.
BifonazoleThe metabolism of Ranolazine can be decreased when combined with Bifonazole.
BiperidenThe serum concentration of Ranolazine can be increased when it is combined with Biperiden.
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Ranolazine.
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Ranolazine.
BortezomibThe metabolism of Ranolazine can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Ranolazine.
BosentanThe serum concentration of Ranolazine can be decreased when it is combined with Bosentan.
BosutinibThe serum concentration of Ranolazine can be increased when it is combined with Bosutinib.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Ranolazine.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Ranolazine.
BrinzolamideThe metabolism of Brinzolamide can be decreased when combined with Ranolazine.
BromazepamThe metabolism of Bromazepam can be decreased when combined with Ranolazine.
BromocriptineThe serum concentration of Ranolazine can be increased when it is combined with Bromocriptine.
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Ranolazine.
BudesonideThe metabolism of Budesonide can be decreased when combined with Ranolazine.
BufuralolThe metabolism of Bufuralol can be decreased when combined with Ranolazine.
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Ranolazine.
BuprenorphineThe serum concentration of Ranolazine can be increased when it is combined with Buprenorphine.
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Ranolazine.
BupropionThe metabolism of Bupropion can be decreased when combined with Ranolazine.
BuspironeThe serum concentration of Ranolazine can be increased when it is combined with Buspirone.
BuspironeThe metabolism of Buspirone can be decreased when combined with Ranolazine.
BusulfanThe metabolism of Busulfan can be decreased when combined with Ranolazine.
ButenafineThe metabolism of Ranolazine can be decreased when combined with Butenafine.
ButoconazoleThe metabolism of Ranolazine can be decreased when combined with Butoconazole.
CabazitaxelThe serum concentration of Ranolazine can be increased when it is combined with Cabazitaxel.
CabergolineThe metabolism of Cabergoline can be decreased when combined with Ranolazine.
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Ranolazine.
CaffeineThe serum concentration of Ranolazine can be increased when it is combined with Caffeine.
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Ranolazine.
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Ranolazine.
CanagliflozinThe serum concentration of Ranolazine can be increased when it is combined with Canagliflozin.
CandesartanThe serum concentration of Ranolazine can be increased when it is combined with Candesartan.
CandicidinThe metabolism of Ranolazine can be decreased when combined with Candicidin.
CaptoprilThe serum concentration of Ranolazine can be increased when it is combined with Captopril.
CaptoprilThe metabolism of Captopril can be decreased when combined with Ranolazine.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Ranolazine.
CarbamazepineThe serum concentration of Ranolazine can be decreased when it is combined with Carbamazepine.
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Ranolazine.
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Ranolazine.
CariprazineThe metabolism of Cariprazine can be decreased when combined with Ranolazine.
CarteololThe metabolism of Carteolol can be decreased when combined with Ranolazine.
CarvedilolThe serum concentration of Ranolazine can be increased when it is combined with Carvedilol.
CarvedilolThe metabolism of Carvedilol can be decreased when combined with Ranolazine.
CaspofunginThe metabolism of Ranolazine can be decreased when combined with Caspofungin.
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Ranolazine.
CeliprololThe metabolism of Celiprolol can be decreased when combined with Ranolazine.
CephalexinThe metabolism of Cephalexin can be decreased when combined with Ranolazine.
CeritinibThe serum concentration of Ceritinib can be increased when it is combined with Ranolazine.
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Ranolazine.
CeruleninThe metabolism of Ranolazine can be decreased when combined with Cerulenin.
CevimelineThe metabolism of Cevimeline can be decreased when combined with Ranolazine.
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Ranolazine.
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Ranolazine.
ChloroquineThe serum concentration of Ranolazine can be increased when it is combined with Chloroquine.
ChloroquineRanolazine may increase the QTc-prolonging activities of Chloroquine.
ChloroxineThe metabolism of Ranolazine can be decreased when combined with Chloroxine.
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Ranolazine.
ChlorpromazineThe serum concentration of Ranolazine can be increased when it is combined with Chlorpromazine.
ChlorpropamideThe serum concentration of Ranolazine can be increased when it is combined with Chlorpropamide.
ChlorprothixeneThe serum concentration of Ranolazine can be increased when it is combined with Chlorprothixene.
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Ranolazine.
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Ranolazine.
CholesterolThe serum concentration of Ranolazine can be increased when it is combined with Cholesterol.
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Ranolazine.
CiclopiroxThe metabolism of Ranolazine can be decreased when combined with Ciclopirox.
CilazaprilThe serum concentration of Ranolazine can be increased when it is combined with Cilazapril.
CilostazolThe metabolism of Cilostazol can be decreased when combined with Ranolazine.
CimetidineThe serum concentration of Ranolazine can be increased when it is combined with Cimetidine.
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Ranolazine.
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Ranolazine.
CiprofloxacinThe serum concentration of Ranolazine can be increased when it is combined with Ciprofloxacin.
CisaprideThe metabolism of Cisapride can be decreased when combined with Ranolazine.
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Ranolazine.
CitalopramThe serum concentration of Ranolazine can be increased when it is combined with Citalopram.
ClarithromycinThe serum concentration of Clarithromycin can be increased when it is combined with Ranolazine.
ClemastineThe metabolism of Ranolazine can be decreased when combined with Clemastine.
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Ranolazine.
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Ranolazine.
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Ranolazine.
ClofazimineThe serum concentration of Ranolazine can be increased when it is combined with Clofazimine.
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Ranolazine.
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Ranolazine.
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Ranolazine.
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Ranolazine.
ClomipramineThe serum concentration of Ranolazine can be increased when it is combined with Clomipramine.
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Ranolazine.
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Ranolazine.
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Ranolazine.
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Ranolazine.
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Ranolazine.
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Ranolazine.
ClotrimazoleThe metabolism of Ranolazine can be decreased when combined with Clotrimazole.
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Ranolazine.
CobicistatThe serum concentration of Ranolazine can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Ranolazine.
CocaineThe metabolism of Cocaine can be decreased when combined with Ranolazine.
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Ranolazine.
ColchicineThe serum concentration of Ranolazine can be increased when it is combined with Colchicine.
ColforsinThe serum concentration of Ranolazine can be increased when it is combined with Colforsin.
ConivaptanThe serum concentration of Ranolazine can be increased when it is combined with Conivaptan.
ConivaptanThe metabolism of Conivaptan can be decreased when combined with Ranolazine.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Ranolazine.
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Ranolazine.
CrizotinibThe serum concentration of Ranolazine can be increased when it is combined with Crizotinib.
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Ranolazine.
CyclophosphamideThe serum concentration of Ranolazine can be increased when it is combined with Cyclophosphamide.
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Ranolazine.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Ranolazine.
CyclosporineThe metabolism of Ranolazine can be decreased when combined with Cyclosporine.
CytarabineThe metabolism of Cytarabine can be decreased when combined with Ranolazine.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Ranolazine.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Ranolazine.
DabrafenibThe serum concentration of Ranolazine can be decreased when it is combined with Dabrafenib.
DaclatasvirThe serum concentration of Ranolazine can be increased when it is combined with Daclatasvir.
DaclatasvirThe metabolism of Daclatasvir can be decreased when combined with Ranolazine.
DactinomycinThe serum concentration of Ranolazine can be increased when it is combined with Dactinomycin.
DantroleneThe metabolism of Dantrolene can be decreased when combined with Ranolazine.
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Ranolazine.
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Ranolazine.
DapsoneThe metabolism of Dapsone can be decreased when combined with Ranolazine.
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Ranolazine.
DarunavirThe serum concentration of Ranolazine can be increased when it is combined with Darunavir.
DarunavirThe metabolism of Darunavir can be decreased when combined with Ranolazine.
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Ranolazine.
DasatinibThe serum concentration of Ranolazine can be increased when it is combined with Dasatinib.
DaunorubicinThe serum concentration of Ranolazine can be increased when it is combined with Daunorubicin.
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Ranolazine.
Decanoic AcidThe metabolism of Ranolazine can be decreased when combined with Decanoic Acid.
DeferasiroxThe serum concentration of Ranolazine can be decreased when it is combined with Deferasirox.
DehydroepiandrosteroneThe metabolism of Dehydroepiandrosterone can be decreased when combined with Ranolazine.
DelavirdineThe metabolism of Delavirdine can be decreased when combined with Ranolazine.
DesipramineThe serum concentration of Ranolazine can be increased when it is combined with Desipramine.
DesipramineThe metabolism of Desipramine can be decreased when combined with Ranolazine.
DesloratadineThe serum concentration of Ranolazine can be increased when it is combined with Desloratadine.
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Ranolazine.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Ranolazine.
DexamethasoneThe serum concentration of Ranolazine can be decreased when it is combined with Dexamethasone.
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Ranolazine.
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Ranolazine.
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Ranolazine.
DextromethorphanThe serum concentration of Ranolazine can be increased when it is combined with Dextromethorphan.
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Ranolazine.
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Ranolazine.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Ranolazine.
DiclofenacThe serum concentration of Ranolazine can be increased when it is combined with Diclofenac.
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Ranolazine.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Ranolazine.
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Ranolazine.
DigoxinThe serum concentration of Ranolazine can be increased when it is combined with Digoxin.
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Ranolazine.
DihydroergotamineThe serum concentration of Ranolazine can be increased when it is combined with Dihydroergotamine.
DihydroergotamineThe metabolism of Dihydroergotamine can be decreased when combined with Ranolazine.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Ranolazine.
DiltiazemThe serum concentration of Ranolazine can be increased when it is combined with Diltiazem.
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Ranolazine.
DipyridamoleThe serum concentration of Ranolazine can be increased when it is combined with Dipyridamole.
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Ranolazine.
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Ranolazine.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Ranolazine.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Ranolazine.
DolasetronRanolazine may increase the QTc-prolonging activities of Dolasetron.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Ranolazine.
DonepezilThe metabolism of Donepezil can be decreased when combined with Ranolazine.
DopamineThe metabolism of Dopamine can be decreased when combined with Ranolazine.
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Ranolazine.
DoxazosinThe serum concentration of Ranolazine can be increased when it is combined with Doxazosin.
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Ranolazine.
DoxepinThe serum concentration of Ranolazine can be increased when it is combined with Doxepin.
DoxepinThe metabolism of Doxepin can be decreased when combined with Ranolazine.
DoxorubicinThe serum concentration of Ranolazine can be increased when it is combined with Doxorubicin.
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Ranolazine.
DoxycyclineThe metabolism of Ranolazine can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Ranolazine can be increased when it is combined with Dronabinol.
DronedaroneThe serum concentration of Ranolazine can be increased when it is combined with Dronedarone.
DronedaroneThe metabolism of Dronedarone can be decreased when combined with Ranolazine.
DroperidolRanolazine may increase the QTc-prolonging activities of Droperidol.
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Ranolazine.
DutasterideThe metabolism of Dutasteride can be decreased when combined with Ranolazine.
EconazoleThe metabolism of Ranolazine can be decreased when combined with Econazole.
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Ranolazine.
EfavirenzThe serum concentration of Ranolazine can be decreased when it is combined with Efavirenz.
EfavirenzThe metabolism of Efavirenz can be decreased when combined with Ranolazine.
EfinaconazoleThe metabolism of Ranolazine can be decreased when combined with Efinaconazole.
ElbasvirThe serum concentration of Ranolazine can be increased when it is combined with Elbasvir.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Ranolazine.
EliglustatThe metabolism of Eliglustat can be decreased when combined with Ranolazine.
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Ranolazine.
EnalaprilThe serum concentration of Ranolazine can be increased when it is combined with Enalapril.
EnalaprilThe metabolism of Enalapril can be decreased when combined with Ranolazine.
EncainideThe metabolism of Encainide can be decreased when combined with Ranolazine.
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Ranolazine.
EnzalutamideThe serum concentration of Ranolazine can be decreased when it is combined with Enzalutamide.
EnzalutamideThe metabolism of Enzalutamide can be decreased when combined with Ranolazine.
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Ranolazine.
EplerenoneThe metabolism of Eplerenone can be decreased when combined with Ranolazine.
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Ranolazine.
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Ranolazine.
ErgonovineThe serum concentration of Ranolazine can be increased when it is combined with Ergonovine.
ErgonovineThe metabolism of Ergonovine can be decreased when combined with Ranolazine.
ErgotamineThe serum concentration of Ranolazine can be increased when it is combined with Ergotamine.
ErgotamineThe metabolism of Ergotamine can be decreased when combined with Ranolazine.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Ranolazine.
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Ranolazine.
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Ranolazine.
Eslicarbazepine acetateThe serum concentration of Ranolazine can be decreased when it is combined with Eslicarbazepine acetate.
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Ranolazine.
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Ranolazine.
EstazolamThe metabolism of Estazolam can be decreased when combined with Ranolazine.
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Ranolazine.
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Ranolazine.
EstramustineThe serum concentration of Ranolazine can be increased when it is combined with Estramustine.
EstramustineThe metabolism of Estramustine can be decreased when combined with Ranolazine.
EstriolThe serum concentration of Estriol can be increased when it is combined with Ranolazine.
EstroneThe serum concentration of Estrone can be increased when it is combined with Ranolazine.
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Ranolazine.
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Ranolazine.
EthanolThe metabolism of Ethanol can be decreased when combined with Ranolazine.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Ranolazine.
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Ranolazine.
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Ranolazine.
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Ranolazine.
EtoposideThe serum concentration of Ranolazine can be increased when it is combined with Etoposide.
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Ranolazine.
EtravirineThe serum concentration of Ranolazine can be decreased when it is combined with Etravirine.
EtravirineThe metabolism of Etravirine can be decreased when combined with Ranolazine.
EverolimusThe metabolism of Everolimus can be decreased when combined with Ranolazine.
ExemestaneThe metabolism of Exemestane can be decreased when combined with Ranolazine.
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Ranolazine.
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Ranolazine.
FelbamateThe metabolism of Felbamate can be decreased when combined with Ranolazine.
FelodipineThe serum concentration of Ranolazine can be increased when it is combined with Felodipine.
FelodipineThe metabolism of Felodipine can be decreased when combined with Ranolazine.
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Ranolazine.
FentanylThe serum concentration of Ranolazine can be increased when it is combined with Fentanyl.
FentanylThe metabolism of Fentanyl can be decreased when combined with Ranolazine.
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Ranolazine.
FexofenadineThe serum concentration of Ranolazine can be increased when it is combined with Fexofenadine.
FidaxomicinThe serum concentration of Ranolazine can be increased when it is combined with Fidaxomicin.
FinasterideThe metabolism of Finasteride can be decreased when combined with Ranolazine.
FingolimodThe metabolism of Fingolimod can be decreased when combined with Ranolazine.
FlecainideRanolazine may increase the QTc-prolonging activities of Flecainide.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Ranolazine.
FluconazoleThe metabolism of Ranolazine can be decreased when combined with Fluconazole.
FlucytosineThe metabolism of Ranolazine can be decreased when combined with Flucytosine.
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Ranolazine.
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Ranolazine.
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Ranolazine.
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Ranolazine.
FluoxetineThe serum concentration of Ranolazine can be increased when it is combined with Fluoxetine.
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Ranolazine.
FlupentixolThe serum concentration of Ranolazine can be increased when it is combined with Flupentixol.
FlupentixolRanolazine may increase the QTc-prolonging activities of Flupentixol.
FluphenazineThe serum concentration of Ranolazine can be increased when it is combined with Fluphenazine.
FluphenazineThe metabolism of Fluphenazine can be decreased when combined with Ranolazine.
FlurazepamThe serum concentration of Ranolazine can be increased when it is combined with Flurazepam.
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Ranolazine.
FlutamideThe metabolism of Flutamide can be decreased when combined with Ranolazine.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Ranolazine.
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be decreased when combined with Ranolazine.
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Ranolazine.
FluvoxamineThe serum concentration of Ranolazine can be increased when it is combined with Fluvoxamine.
FluvoxamineThe metabolism of Fluvoxamine can be decreased when combined with Ranolazine.
FormoterolThe metabolism of Formoterol can be decreased when combined with Ranolazine.
FosamprenavirThe metabolism of Fosamprenavir can be decreased when combined with Ranolazine.
FosaprepitantThe serum concentration of Ranolazine can be increased when it is combined with Fosaprepitant.
FosphenytoinThe serum concentration of Ranolazine can be decreased when it is combined with Fosphenytoin.
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Ranolazine.
Fusidic AcidThe serum concentration of Ranolazine can be increased when it is combined with Fusidic Acid.
Gadobenic acidRanolazine may increase the QTc-prolonging activities of Gadobenic acid.
GalantamineThe metabolism of Galantamine can be decreased when combined with Ranolazine.
GefitinibThe serum concentration of Ranolazine can be increased when it is combined with Gefitinib.
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Ranolazine.
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Ranolazine.
GemifloxacinRanolazine may increase the QTc-prolonging activities of Gemifloxacin.
GenisteinThe serum concentration of Ranolazine can be increased when it is combined with Genistein.
GlipizideThe metabolism of Glipizide can be decreased when combined with Ranolazine.
GlyburideThe serum concentration of Ranolazine can be increased when it is combined with Glyburide.
GlyburideThe metabolism of Glyburide can be decreased when combined with Ranolazine.
GlycerolThe serum concentration of Ranolazine can be increased when it is combined with Glycerol.
GlyphosateThe metabolism of Ranolazine can be decreased when combined with Glyphosate.
GoserelinRanolazine may increase the QTc-prolonging activities of Goserelin.
Gramicidin DThe serum concentration of Ranolazine can be increased when it is combined with Gramicidin D.
GranisetronRanolazine may increase the QTc-prolonging activities of Granisetron.
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Ranolazine.
GrepafloxacinThe serum concentration of Ranolazine can be increased when it is combined with Grepafloxacin.
GriseofulvinThe metabolism of Ranolazine can be decreased when combined with Griseofulvin.
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Ranolazine.
HalofantrineThe metabolism of Halofantrine can be decreased when combined with Ranolazine.
HaloperidolThe serum concentration of Ranolazine can be increased when it is combined with Haloperidol.
HaloproginThe metabolism of Ranolazine can be decreased when combined with Haloprogin.
HalothaneThe metabolism of Halothane can be decreased when combined with Ranolazine.
HexetidineThe metabolism of Ranolazine can be decreased when combined with Hexetidine.
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Ranolazine.
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Ranolazine.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Ranolazine.
HydrocortisoneThe serum concentration of Ranolazine can be increased when it is combined with Hydrocortisone.
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Ranolazine.
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Ranolazine.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Ranolazine.
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Ranolazine.
IbutilideRanolazine may increase the QTc-prolonging activities of Ibutilide.
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Ranolazine.
IdelalisibThe serum concentration of Ranolazine can be increased when it is combined with Idelalisib.
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Ranolazine resulting in a loss in efficacy.
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Ranolazine.
ImatinibThe serum concentration of Ranolazine can be increased when it is combined with Imatinib.
ImipramineThe serum concentration of Ranolazine can be increased when it is combined with Imipramine.
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Ranolazine.
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Ranolazine.
IndapamideThe metabolism of Indapamide can be decreased when combined with Ranolazine.
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Ranolazine.
IndomethacinThe serum concentration of Ranolazine can be increased when it is combined with Indomethacin.
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Ranolazine.
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Ranolazine.
IsavuconazoniumThe serum concentration of Ranolazine can be increased when it is combined with Isavuconazonium.
IsavuconazoniumThe metabolism of Isavuconazonium can be decreased when combined with Ranolazine.
IsoconazoleThe metabolism of Ranolazine can be decreased when combined with Isoconazole.
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Ranolazine.
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Ranolazine.
IsradipineThe metabolism of Isradipine can be decreased when combined with Ranolazine.
ItraconazoleThe serum concentration of Ranolazine can be increased when it is combined with Itraconazole.
ItraconazoleThe metabolism of Itraconazole can be decreased when combined with Ranolazine.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Ranolazine.
IvacaftorThe serum concentration of Ranolazine can be increased when it is combined with Ivacaftor.
IvacaftorThe metabolism of Ivacaftor can be decreased when combined with Ranolazine.
IvermectinThe serum concentration of Ranolazine can be increased when it is combined with Ivermectin.
IxabepiloneThe metabolism of Ixabepilone can be decreased when combined with Ranolazine.
IxazomibThe metabolism of Ixazomib can be decreased when combined with Ranolazine.
KetamineThe serum concentration of Ranolazine can be increased when it is combined with Ketamine.
KetamineThe metabolism of Ketamine can be decreased when combined with Ranolazine.
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Ranolazine.
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Ranolazine.
KetoconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Ranolazine.
LabetalolThe metabolism of Labetalol can be decreased when combined with Ranolazine.
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Ranolazine.
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Ranolazine.
LansoprazoleThe serum concentration of Ranolazine can be increased when it is combined with Lansoprazole.
LapatinibThe serum concentration of Ranolazine can be increased when it is combined with Lapatinib.
LapatinibThe metabolism of Lapatinib can be decreased when combined with Ranolazine.
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Ranolazine.
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Ranolazine.
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Ranolazine.
LercanidipineThe metabolism of Lercanidipine can be decreased when combined with Ranolazine.
LetrozoleThe metabolism of Letrozole can be decreased when combined with Ranolazine.
LeuprolideRanolazine may increase the QTc-prolonging activities of Leuprolide.
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Ranolazine.
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Ranolazine.
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Ranolazine.
LevodopaThe metabolism of Levodopa can be decreased when combined with Ranolazine.
LevofloxacinThe serum concentration of Ranolazine can be increased when it is combined with Levofloxacin.
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Ranolazine.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Ranolazine.
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Ranolazine.
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Ranolazine.
LidocaineThe serum concentration of Ranolazine can be increased when it is combined with Lidocaine.
LidocaineThe metabolism of Lidocaine can be decreased when combined with Ranolazine.
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Ranolazine.
LisinoprilThe serum concentration of Ranolazine can be increased when it is combined with Lisinopril.
LisurideThe metabolism of Lisuride can be decreased when combined with Ranolazine.
LomitapideThe serum concentration of Ranolazine can be increased when it is combined with Lomitapide.
LomustineThe metabolism of Lomustine can be decreased when combined with Ranolazine.
LoperamideThe serum concentration of Ranolazine can be increased when it is combined with Loperamide.
LopinavirThe serum concentration of Ranolazine can be increased when it is combined with Lopinavir.
LopinavirThe metabolism of Lopinavir can be decreased when combined with Ranolazine.
LoratadineThe serum concentration of Ranolazine can be increased when it is combined with Loratadine.
LoratadineThe metabolism of Loratadine can be decreased when combined with Ranolazine.
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Ranolazine.
LosartanThe serum concentration of Ranolazine can be increased when it is combined with Losartan.
LovastatinThe serum concentration of Ranolazine can be increased when it is combined with Lovastatin.
LovastatinRanolazine may increase the myopathic rhabdomyolysis activities of Lovastatin.
LuliconazoleThe serum concentration of Ranolazine can be increased when it is combined with Luliconazole.
LumefantrineThe metabolism of Lumefantrine can be decreased when combined with Ranolazine.
LurasidoneThe metabolism of Lurasidone can be decreased when combined with Ranolazine.
MacitentanThe metabolism of Macitentan can be decreased when combined with Ranolazine.
MannitolThe serum concentration of Mannitol can be increased when it is combined with Ranolazine.
MaprotilineThe serum concentration of Ranolazine can be increased when it is combined with Maprotiline.
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Ranolazine.
MaravirocThe metabolism of Maraviroc can be decreased when combined with Ranolazine.
MebendazoleThe serum concentration of Ranolazine can be increased when it is combined with Mebendazole.
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Ranolazine.
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be decreased when combined with Ranolazine.
MefloquineThe serum concentration of Ranolazine can be increased when it is combined with Mefloquine.
MefloquineThe metabolism of Mefloquine can be decreased when combined with Ranolazine.
Megestrol acetateThe serum concentration of Ranolazine can be increased when it is combined with Megestrol acetate.
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Ranolazine.
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Ranolazine.
MeprobamateThe serum concentration of Ranolazine can be increased when it is combined with Meprobamate.
MequitazineThe metabolism of Mequitazine can be decreased when combined with Ranolazine.
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Ranolazine.
MetforminThe serum concentration of Metformin can be increased when it is combined with Ranolazine.
MethadoneThe serum concentration of Ranolazine can be increased when it is combined with Methadone.
MethadoneRanolazine may increase the QTc-prolonging activities of Methadone.
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Ranolazine.
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Ranolazine.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Ranolazine.
MethotrimeprazineThe metabolism of Methotrimeprazine can be decreased when combined with Ranolazine.
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Ranolazine.
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Ranolazine.
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Ranolazine.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Ranolazine.
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Ranolazine.
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Ranolazine.
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Ranolazine.
MetoprololThe serum concentration of Ranolazine can be increased when it is combined with Metoprolol.
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Ranolazine.
MevastatinThe metabolism of Ranolazine can be decreased when combined with Mevastatin.
MexiletineThe metabolism of Mexiletine can be decreased when combined with Ranolazine.
MianserinThe metabolism of Mianserin can be decreased when combined with Ranolazine.
MibefradilThe serum concentration of Ranolazine can be increased when it is combined with Mibefradil.
MibefradilThe metabolism of Mibefradil can be decreased when combined with Ranolazine.
MicafunginThe metabolism of Ranolazine can be decreased when combined with Micafungin.
MiconazoleThe metabolism of Ranolazine can be decreased when combined with Miconazole.
MidazolamThe serum concentration of Ranolazine can be increased when it is combined with Midazolam.
MifepristoneThe serum concentration of Ranolazine can be increased when it is combined with Mifepristone.
MifepristoneThe metabolism of Mifepristone can be decreased when combined with Ranolazine.
MiltefosineThe metabolism of Ranolazine can be decreased when combined with Miltefosine.
MinaprineThe metabolism of Minaprine can be decreased when combined with Ranolazine.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Ranolazine.
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Ranolazine.
MitomycinThe serum concentration of Ranolazine can be increased when it is combined with Mitomycin.
MitotaneThe serum concentration of Ranolazine can be decreased when it is combined with Mitotane.
MitoxantroneThe serum concentration of Ranolazine can be increased when it is combined with Mitoxantrone.
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Ranolazine.
ModafinilThe serum concentration of Ranolazine can be decreased when it is combined with Modafinil.
ModafinilThe metabolism of Modafinil can be decreased when combined with Ranolazine.
MonensinThe metabolism of Ranolazine can be decreased when combined with Monensin.
MontelukastThe metabolism of Montelukast can be decreased when combined with Ranolazine.
MorphineThe serum concentration of Ranolazine can be increased when it is combined with Morphine.
MoxifloxacinRanolazine may increase the QTc-prolonging activities of Moxifloxacin.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Ranolazine.
MyxothiazolThe metabolism of Ranolazine can be decreased when combined with Myxothiazol.
NadololThe serum concentration of Nadolol can be increased when it is combined with Ranolazine.
NafcillinThe serum concentration of Ranolazine can be decreased when it is combined with Nafcillin.
NaftifineThe metabolism of Ranolazine can be decreased when combined with Naftifine.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Ranolazine.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Ranolazine.
NaltrexoneThe serum concentration of Ranolazine can be increased when it is combined with Naltrexone.
NaringeninThe serum concentration of Ranolazine can be increased when it is combined with Naringenin.
NatamycinThe metabolism of Ranolazine can be decreased when combined with Natamycin.
NateglinideThe metabolism of Nateglinide can be decreased when combined with Ranolazine.
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Ranolazine.
NefazodoneThe serum concentration of Ranolazine can be increased when it is combined with Nefazodone.
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Ranolazine.
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Ranolazine.
NeostigmineThe serum concentration of Ranolazine can be increased when it is combined with Neostigmine.
NetupitantThe serum concentration of Ranolazine can be increased when it is combined with Netupitant.
NetupitantThe metabolism of Netupitant can be decreased when combined with Ranolazine.
NevirapineThe serum concentration of Ranolazine can be decreased when it is combined with Nevirapine.
NevirapineThe metabolism of Nevirapine can be decreased when combined with Ranolazine.
NicardipineThe serum concentration of Ranolazine can be increased when it is combined with Nicardipine.
NicergolineThe metabolism of Nicergoline can be decreased when combined with Ranolazine.
NicotineThe metabolism of Nicotine can be decreased when combined with Ranolazine.
NifedipineThe serum concentration of Ranolazine can be increased when it is combined with Nifedipine.
NilotinibThe serum concentration of Ranolazine can be increased when it is combined with Nilotinib.
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Ranolazine.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Ranolazine.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Ranolazine.
NisoldipineThe serum concentration of Ranolazine can be increased when it is combined with Nisoldipine.
NisoldipineThe metabolism of Nisoldipine can be decreased when combined with Ranolazine.
NitrazepamThe serum concentration of Ranolazine can be increased when it is combined with Nitrazepam.
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Ranolazine.
NitrendipineThe serum concentration of Ranolazine can be increased when it is combined with Nitrendipine.
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Ranolazine.
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Ranolazine.
NitroxolineThe metabolism of Ranolazine can be decreased when combined with Nitroxoline.
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Ranolazine.
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Ranolazine.
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Ranolazine.
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Ranolazine.
NystatinThe metabolism of Ranolazine can be decreased when combined with Nystatin.
OfloxacinRanolazine may increase the QTc-prolonging activities of Ofloxacin.
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Ranolazine.
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Ranolazine.
OlaparibThe metabolism of Ranolazine can be decreased when combined with Olaparib.
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Ranolazine.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Ranolazine.
OmeprazoleThe serum concentration of Ranolazine can be increased when it is combined with Omeprazole.
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Ranolazine.
OndansetronRanolazine may increase the QTc-prolonging activities of Ondansetron.
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Ranolazine.
OsimertinibThe serum concentration of Osimertinib can be increased when it is combined with Ranolazine.
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Ranolazine.
OxazepamThe metabolism of Oxazepam can be decreased when combined with Ranolazine.
OxiconazoleThe metabolism of Ranolazine can be decreased when combined with Oxiconazole.
OxybutyninThe metabolism of Oxybutynin can be decreased when combined with Ranolazine.
OxycodoneThe metabolism of Oxycodone can be decreased when combined with Ranolazine.
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Ranolazine.
P-NitrophenolThe serum concentration of Ranolazine can be increased when it is combined with P-Nitrophenol.
PaclitaxelThe serum concentration of Ranolazine can be increased when it is combined with Paclitaxel.
pafuramidineThe metabolism of Ranolazine can be decreased when combined with pafuramidine.
PalbociclibThe serum concentration of Ranolazine can be increased when it is combined with Palbociclib.
PalbociclibThe metabolism of Palbociclib can be decreased when combined with Ranolazine.
PaliperidoneRanolazine may increase the QTc-prolonging activities of Paliperidone.
Palmitic AcidThe serum concentration of Ranolazine can be increased when it is combined with Palmitic Acid.
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Ranolazine.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Ranolazine.
PantoprazoleThe serum concentration of Ranolazine can be increased when it is combined with Pantoprazole.
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Ranolazine.
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Ranolazine.
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Ranolazine.
ParecoxibThe metabolism of Parecoxib can be decreased when combined with Ranolazine.
ParicalcitolThe metabolism of Paricalcitol can be decreased when combined with Ranolazine.
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Ranolazine.
ParoxetineThe serum concentration of Ranolazine can be increased when it is combined with Paroxetine.
ParoxetineThe metabolism of Paroxetine can be decreased when combined with Ranolazine.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Ranolazine.
PentamidineThe metabolism of Ranolazine can be decreased when combined with Pentamidine.
PentamidineRanolazine may increase the QTc-prolonging activities of Pentamidine.
PentobarbitalThe serum concentration of Ranolazine can be decreased when it is combined with Pentobarbital.
PerampanelThe metabolism of Perampanel can be decreased when combined with Ranolazine.
PerflutrenRanolazine may increase the QTc-prolonging activities of Perflutren.
PergolideThe metabolism of Pergolide can be decreased when combined with Ranolazine.
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Ranolazine.
PerindoprilThe serum concentration of Ranolazine can be increased when it is combined with Perindopril.
PermethrinThe metabolism of Permethrin can be decreased when combined with Ranolazine.
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Ranolazine.
PethidineThe metabolism of Pethidine can be decreased when combined with Ranolazine.
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Ranolazine.
PhenforminThe metabolism of Phenformin can be decreased when combined with Ranolazine.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Ranolazine.
PhenobarbitalThe serum concentration of Ranolazine can be decreased when it is combined with Phenobarbital.
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Ranolazine.
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Ranolazine.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Ranolazine.
PhenytoinThe serum concentration of Ranolazine can be decreased when it is combined with Phenytoin.
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Ranolazine.
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Ranolazine.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Ranolazine.
PinacidilThe metabolism of Pinacidil can be decreased when combined with Ranolazine.
PindololThe metabolism of Pindolol can be decreased when combined with Ranolazine.
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Ranolazine.
PiperazineThe metabolism of Piperazine can be decreased when combined with Ranolazine.
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Ranolazine.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Ranolazine.
PodofiloxThe metabolism of Podofilox can be decreased when combined with Ranolazine.
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Ranolazine.
PonatinibThe serum concentration of Ranolazine can be increased when it is combined with Ponatinib.
PosaconazoleThe serum concentration of Ranolazine can be increased when it is combined with Posaconazole.
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Ranolazine.
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Ranolazine.
PravastatinThe serum concentration of Ranolazine can be increased when it is combined with Pravastatin.
PrazepamThe metabolism of Prazepam can be decreased when combined with Ranolazine.
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Ranolazine.
PrazosinThe serum concentration of Ranolazine can be increased when it is combined with Prazosin.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Ranolazine.
PrednisoneThe serum concentration of Ranolazine can be increased when it is combined with Prednisone.
PrimaquineRanolazine may increase the QTc-prolonging activities of Primaquine.
PrimidoneThe serum concentration of Ranolazine can be decreased when it is combined with Primidone.
ProbenecidThe serum concentration of Ranolazine can be increased when it is combined with Probenecid.
ProcainamideThe metabolism of Procainamide can be decreased when combined with Ranolazine.
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Ranolazine.
ProgesteroneThe serum concentration of Ranolazine can be increased when it is combined with Progesterone.
ProguanilThe metabolism of Proguanil can be decreased when combined with Ranolazine.
PromazineRanolazine may increase the QTc-prolonging activities of Promazine.
PromethazineThe serum concentration of Ranolazine can be increased when it is combined with Promethazine.
PromethazineThe metabolism of Promethazine can be decreased when combined with Ranolazine.
PropafenoneThe serum concentration of Ranolazine can be increased when it is combined with Propafenone.
PropofolThe metabolism of Propofol can be decreased when combined with Ranolazine.
PropranololThe serum concentration of Ranolazine can be increased when it is combined with Propranolol.
ProtriptylineThe serum concentration of Ranolazine can be increased when it is combined with Protriptyline.
ProtriptylineThe metabolism of Protriptyline can be decreased when combined with Ranolazine.
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Ranolazine.
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Ranolazine.
QuazepamThe metabolism of Quazepam can be decreased when combined with Ranolazine.
QuercetinThe serum concentration of Ranolazine can be increased when it is combined with Quercetin.
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Ranolazine.
QuinacrineThe serum concentration of Ranolazine can be increased when it is combined with Quinacrine.
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Ranolazine.
QuinidineThe serum concentration of Ranolazine can be increased when it is combined with Quinidine.
QuinineThe serum concentration of Ranolazine can be increased when it is combined with Quinine.
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Ranolazine.
RadicicolThe metabolism of Ranolazine can be decreased when combined with Radicicol.
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Ranolazine.
RamelteonThe metabolism of Ramelteon can be decreased when combined with Ranolazine.
RanitidineThe serum concentration of Ranolazine can be increased when it is combined with Ranitidine.
ReboxetineThe serum concentration of Ranolazine can be increased when it is combined with Reboxetine.
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Ranolazine.
RegorafenibThe serum concentration of Ranolazine can be increased when it is combined with Regorafenib.
RegorafenibThe metabolism of Regorafenib can be decreased when combined with Ranolazine.
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Ranolazine.
RepaglinideThe metabolism of Repaglinide can be decreased when combined with Ranolazine.
repinotanThe metabolism of repinotan can be decreased when combined with Ranolazine.
ReserpineThe serum concentration of Ranolazine can be increased when it is combined with Reserpine.
RetapamulinThe metabolism of Retapamulin can be decreased when combined with Ranolazine.
RifabutinThe serum concentration of Ranolazine can be decreased when it is combined with Rifabutin.
RifabutinThe metabolism of Rifabutin can be decreased when combined with Ranolazine.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Ranolazine.
RifampicinThe serum concentration of Ranolazine can be decreased when it is combined with Rifampicin.
RifapentineThe serum concentration of Ranolazine can be decreased when it is combined with Rifapentine.
RilpivirineThe serum concentration of Ranolazine can be increased when it is combined with Rilpivirine.
RilpivirineThe metabolism of Rilpivirine can be decreased when combined with Ranolazine.
RimonabantThe metabolism of Rimonabant can be decreased when combined with Ranolazine.
RiociguatThe metabolism of Riociguat can be decreased when combined with Ranolazine.
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Ranolazine.
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Ranolazine.
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Ranolazine.
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Ranolazine.
RolapitantThe serum concentration of Ranolazine can be increased when it is combined with Rolapitant.
RolapitantThe metabolism of Rolapitant can be decreased when combined with Ranolazine.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Ranolazine.
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Ranolazine.
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Ranolazine.
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Ranolazine.
RotigotineThe metabolism of Rotigotine can be decreased when combined with Ranolazine.
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Ranolazine.
RuxolitinibThe metabolism of Ruxolitinib can be decreased when combined with Ranolazine.
Salicylhydroxamic AcidThe metabolism of Ranolazine can be decreased when combined with Salicylhydroxamic Acid.
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Ranolazine.
Salicylic acidThe metabolism of Ranolazine can be decreased when combined with Salicylic acid.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Ranolazine.
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Ranolazine.
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Ranolazine.
ScopolamineThe serum concentration of Ranolazine can be increased when it is combined with Scopolamine.
SelegilineThe serum concentration of Ranolazine can be increased when it is combined with Selegiline.
SelegilineThe metabolism of Selegiline can be decreased when combined with Ranolazine.
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Ranolazine.
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Ranolazine.
SertaconazoleThe metabolism of Ranolazine can be decreased when combined with Sertaconazole.
SertindoleThe metabolism of Sertindole can be decreased when combined with Ranolazine.
SertralineThe serum concentration of Ranolazine can be increased when it is combined with Sertraline.
SertralineThe metabolism of Sertraline can be decreased when combined with Ranolazine.
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Ranolazine.
SibutramineThe metabolism of Sibutramine can be decreased when combined with Ranolazine.
SildenafilThe metabolism of Sildenafil can be decreased when combined with Ranolazine.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Ranolazine.
SiltuximabThe serum concentration of Ranolazine can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Ranolazine can be increased when it is combined with Simeprevir.
SimvastatinThe serum concentration of Ranolazine can be increased when it is combined with Simvastatin.
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Ranolazine.
SinefunginThe metabolism of Ranolazine can be decreased when combined with Sinefungin.
SirolimusThe metabolism of Ranolazine can be decreased when combined with Sirolimus.
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Ranolazine.
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Ranolazine.
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Ranolazine.
SonidegibThe metabolism of Sonidegib can be decreased when combined with Ranolazine.
SorafenibThe serum concentration of Ranolazine can be increased when it is combined with Sorafenib.
SotalolRanolazine may increase the QTc-prolonging activities of Sotalol.
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Ranolazine.
SparteineThe metabolism of Sparteine can be decreased when combined with Ranolazine.
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Ranolazine.
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Ranolazine.
SpironolactoneThe serum concentration of Ranolazine can be increased when it is combined with Spironolactone.
St. John's WortThe serum concentration of Ranolazine can be decreased when it is combined with St. John's Wort.
StaurosporineThe serum concentration of Ranolazine can be increased when it is combined with Staurosporine.
StiripentolThe serum concentration of Ranolazine can be increased when it is combined with Stiripentol.
SufentanilThe metabolism of Sufentanil can be decreased when combined with Ranolazine.
SulconazoleThe metabolism of Ranolazine can be decreased when combined with Sulconazole.
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Ranolazine.
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Ranolazine.
SulfinpyrazoneThe serum concentration of Ranolazine can be increased when it is combined with Sulfinpyrazone.
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Ranolazine.
SulfisoxazoleRanolazine may increase the QTc-prolonging activities of Sulfisoxazole.
SulfisoxazoleThe metabolism of Ranolazine can be decreased when combined with Sulfisoxazole.
SumatriptanThe serum concentration of Ranolazine can be increased when it is combined with Sumatriptan.
SunitinibThe serum concentration of Ranolazine can be increased when it is combined with Sunitinib.
SunitinibThe metabolism of Sunitinib can be decreased when combined with Ranolazine.
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Ranolazine.
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Ranolazine.
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Ranolazine.
TacrineThe serum concentration of Ranolazine can be increased when it is combined with Tacrine.
TacrolimusThe serum concentration of Ranolazine can be increased when it is combined with Tacrolimus.
TadalafilThe metabolism of Tadalafil can be decreased when combined with Ranolazine.
TamoxifenThe serum concentration of Ranolazine can be increased when it is combined with Tamoxifen.
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Ranolazine.
TapentadolThe metabolism of Tapentadol can be decreased when combined with Ranolazine.
TasosartanThe metabolism of Tasosartan can be decreased when combined with Ranolazine.
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Ranolazine.
Taurocholic AcidThe serum concentration of Ranolazine can be increased when it is combined with Taurocholic Acid.
TavaboroleThe metabolism of Ranolazine can be decreased when combined with Tavaborole.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Ranolazine.
TegaserodThe metabolism of Tegaserod can be decreased when combined with Ranolazine.
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Ranolazine.
TelavancinRanolazine may increase the QTc-prolonging activities of Telavancin.
TelithromycinThe serum concentration of Ranolazine can be increased when it is combined with Telithromycin.
TelithromycinRanolazine may increase the QTc-prolonging activities of Telithromycin.
TelmisartanThe serum concentration of Ranolazine can be increased when it is combined with Telmisartan.
TemazepamThe metabolism of Temazepam can be decreased when combined with Ranolazine.
TemsirolimusThe serum concentration of Ranolazine can be increased when it is combined with Temsirolimus.
TeniposideThe metabolism of Teniposide can be decreased when combined with Ranolazine.
TerazosinThe serum concentration of Ranolazine can be increased when it is combined with Terazosin.
TerbinafineThe metabolism of Ranolazine can be decreased when combined with Terbinafine.
TerconazoleThe metabolism of Ranolazine can be decreased when combined with Terconazole.
TerfenadineThe serum concentration of Ranolazine can be increased when it is combined with Terfenadine.
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Ranolazine.
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Ranolazine.
TestosteroneThe serum concentration of Ranolazine can be increased when it is combined with Testosterone.
TestosteroneThe metabolism of Testosterone can be decreased when combined with Ranolazine.
TetrabenazineThe metabolism of Tetrabenazine can be decreased when combined with Ranolazine.
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Ranolazine.
TheophyllineThe metabolism of Theophylline can be decreased when combined with Ranolazine.
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Ranolazine.
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Ranolazine.
ThymolThe metabolism of Ranolazine can be decreased when combined with Thymol.
TiagabineThe metabolism of Tiagabine can be decreased when combined with Ranolazine.
TicagrelorThe serum concentration of Ranolazine can be increased when it is combined with Ticagrelor.
TiclopidineThe metabolism of Ranolazine can be decreased when combined with Ticlopidine.
TimololThe serum concentration of Timolol can be increased when it is combined with Ranolazine.
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Ranolazine.
TioconazoleThe metabolism of Ranolazine can be decreased when combined with Tioconazole.
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Ranolazine.
TipranavirThe metabolism of Tipranavir can be decreased when combined with Ranolazine.
TocilizumabThe serum concentration of Ranolazine can be decreased when it is combined with Tocilizumab.
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Ranolazine.
TolnaftateThe metabolism of Ranolazine can be decreased when combined with Tolnaftate.
TolterodineThe metabolism of Tolterodine can be decreased when combined with Ranolazine.
TolvaptanThe serum concentration of Ranolazine can be increased when it is combined with Tolvaptan.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Ranolazine.
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Ranolazine.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Ranolazine.
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Ranolazine.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Ranolazine.
TrazodoneThe metabolism of Trazodone can be decreased when combined with Ranolazine.
TretinoinThe metabolism of Tretinoin can be decreased when combined with Ranolazine.
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Ranolazine.
TriazolamThe metabolism of Triazolam can be decreased when combined with Ranolazine.
TrifluoperazineThe serum concentration of Ranolazine can be increased when it is combined with Trifluoperazine.
TriflupromazineThe serum concentration of Ranolazine can be increased when it is combined with Triflupromazine.
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Ranolazine.
TrimethoprimThe serum concentration of Ranolazine can be increased when it is combined with Trimethoprim.
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Ranolazine.
TrimetrexateThe metabolism of Ranolazine can be decreased when combined with Trimetrexate.
TrimipramineThe serum concentration of Ranolazine can be increased when it is combined with Trimipramine.
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Ranolazine.
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Ranolazine.
TroleandomycinThe serum concentration of Ranolazine can be increased when it is combined with Troleandomycin.
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Ranolazine.
UdenafilThe metabolism of Udenafil can be decreased when combined with Ranolazine.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Ranolazine.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Ranolazine.
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Ranolazine.
VandetanibThe metabolism of Vandetanib can be decreased when combined with Ranolazine.
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Ranolazine.
VardenafilThe metabolism of Vardenafil can be decreased when combined with Ranolazine.
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Ranolazine.
VemurafenibThe metabolism of Vemurafenib can be decreased when combined with Ranolazine.
VenlafaxineThe serum concentration of Ranolazine can be increased when it is combined with Venlafaxine.
VerapamilThe serum concentration of Ranolazine can be increased when it is combined with Verapamil.
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Ranolazine.
VilanterolThe metabolism of Vilanterol can be decreased when combined with Ranolazine.
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Ranolazine.
VinblastineThe serum concentration of Ranolazine can be increased when it is combined with Vinblastine.
VincristineThe serum concentration of Ranolazine can be increased when it is combined with Vincristine.
VindesineThe serum concentration of Vindesine can be increased when it is combined with Ranolazine.
VinorelbineThe serum concentration of Ranolazine can be increased when it is combined with Vinorelbine.
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Ranolazine.
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Ranolazine.
VoriconazoleThe serum concentration of Ranolazine can be increased when it is combined with Voriconazole.
VoriconazoleThe metabolism of Voriconazole can be decreased when combined with Ranolazine.
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Ranolazine.
WarfarinThe metabolism of Warfarin can be decreased when combined with Ranolazine.
YohimbineThe metabolism of Yohimbine can be decreased when combined with Ranolazine.
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Ranolazine.
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Ranolazine.
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Ranolazine.
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Ranolazine.
ZileutonThe metabolism of Zileuton can be decreased when combined with Ranolazine.
ZimelidineThe serum concentration of Ranolazine can be increased when it is combined with Zimelidine.
ZiprasidoneThe metabolism of Ziprasidone can be decreased when combined with Ranolazine.
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Ranolazine.
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Ranolazine.
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Ranolazine.
ZopicloneThe metabolism of Zopiclone can be decreased when combined with Ranolazine.
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Ranolazine.
Food Interactions
  • Grapefruit and grapefruit juice should be avoided throughout treatment.
  • Take without regard to meals.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Voltage-gated sodium channel activity involved in sa node cell action potential
Specific Function:
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is respon...
Gene Name:
SCN5A
Uniprot ID:
Q14524
Molecular Weight:
226937.475 Da
References
  1. Hale SL, Kloner RA: Ranolazine, an inhibitor of the late sodium channel current, reduces postischemic myocardial dysfunction in the rabbit. J Cardiovasc Pharmacol Ther. 2006 Dec;11(4):249-55. [PubMed:17220471 ]
  2. Rajamani S, Shryock JC, Belardinelli L: Block of tetrodotoxin-sensitive, Na(V)1.7 and tetrodotoxin-resistant, Na(V)1.8, Na+ channels by ranolazine. Channels (Austin). 2008 Nov-Dec;2(6):449-60. Epub 2008 Nov 7. [PubMed:19077543 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Voltage-gated sodium channel activity
Specific Function:
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, es...
Gene Name:
SCN9A
Uniprot ID:
Q15858
Molecular Weight:
226370.175 Da
References
  1. Rajamani S, Shryock JC, Belardinelli L: Block of tetrodotoxin-sensitive, Na(V)1.7 and tetrodotoxin-resistant, Na(V)1.8, Na+ channels by ranolazine. Channels (Austin). 2008 Nov-Dec;2(6):449-60. Epub 2008 Nov 7. [PubMed:19077543 ]
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
Comments
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Drug created on June 13, 2005 07:24 / Updated on September 26, 2016 02:13